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https://www.readbyqxmd.com/read/27908218/risk-factors-for-dural-tears-a-study-of-elective-spine-surgery
#1
Meghan E Murphy, Panagiotis Kerezoudis, Mohammed Ali Alvi, Brandon A McCutcheon, Patrick R Maloney, Lorenzo Rinaldo, Daniel Shepherd, Daniel S Ubl, William E Krauss, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE: This study moves beyond previous cohort studies and benchmark data by studying a population of elective spine surgery from a multicenter registry in an effort to validate, disprove, and/or identify novel risk factors for dural tears. METHODS: A retrospective cohort analysis queried a multicenter registry for patients with degenerative spinal diagnoses undergoing elective spinal surgery from 2010-2014. Multivariable logistic regression analysis interrogated for independent risk factors of dural tears...
December 2, 2016: Neurological Research
https://www.readbyqxmd.com/read/27871417/large-bm-intra-articular-allograft
#2
REVIEW
Joan R Williams, Michael E Brage
Posttraumatic tibiotalar arthritis is a challenging problem in young, active patients. Many of these patients do not want to pursue ankle arthrodesis after they fail conservative treatment measures, as they wish to preserve joint motion. Osteochondral shell allograft arthroplasty has been described as a reasonable alternative for treating these patients. The procedure itself is technically demanding; however, with improvements in surgical technique and adequate preoperative patient counseling, it provides improvement in ankle function and has good outcomes for most patients at long-term follow-up...
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27866865/accelerated-partial-breast-irradiation-executive-summary-for-the-update-of-an-astro-evidence-based-consensus-statement
#3
Candace Correa, Eleanor E Harris, Maria Cristina Leonardi, Benjamin D Smith, Alphonse G Taghian, Alastair M Thompson, Julia White, Jay R Harris
PURPOSE: To update the accelerated partial breast irradiation Consensus Statement published in 2009 and provide guidance on use of intraoperative radiation therapy (IORT) for partial breast irradiation in early-stage breast cancer, based on published evidence complemented by expert opinion. METHODS AND MATERIALS: A systematic PubMed search using the same terms as the original Consensus Statement yielded 419 articles; 44 articles were selected. The authors synthesized the published evidence and, through a series of conference calls and e-mails, reached consensus regarding the recommendations...
September 17, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27853167/what-kind-of-sexual-dysfunction-is-most-common-among-overweight-and-obese-women-in-reproductive-age
#4
S Rabiepoor, H R Khalkhali, E Sadeghi
The aim of this study was to investigate the association between body mass index (BMI) and sexual health and determine what kind of sexual dysfunction is most common among overweight and obese women in reproductive age from Iran. A cross-sectional descriptive design was adopted. The data of 198 women who referred to health centers during 2014-2015 in Iran were collected through convenient sampling. Data were collected using a demographic questionnaire, female sexual function and sexual satisfaction indexes...
November 17, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27843641/esmo-asco-recommendations-for-a-global-curriculum-in-medical-oncology-edition-2016
#5
REVIEW
Christian Dittrich, Michael Kosty, Svetlana Jezdic, Doug Pyle, Rossana Berardi, Jonas Bergh, Nagi El-Saghir, Jean-Pierre Lotz, Pia Österlund, Nicholas Pavlidis, Gunta Purkalne, Ahmad Awada, Susana Banerjee, Smita Bhatia, Jan Bogaerts, Jan Buckner, Fatima Cardoso, Paolo Casali, Edward Chu, Julia Lee Close, Bertrand Coiffier, Roisin Connolly, Sarah Coupland, Luigi De Petris, Maria De Santis, Elisabeth G E de Vries, Don S Dizon, Jennifer Duff, Linda R Duska, Alexandru Eniu, Marc Ernstoff, Enriqueta Felip, Martin F Fey, Jill Gilbert, Nicolas Girard, Andor W J M Glaudemans, Priya K Gopalan, Axel Grothey, Stephen M Hahn, Diana Hanna, Christian Herold, Jørn Herrstedt, Krisztian Homicsko, Dennie V Jones, Lorenz Jost, Ulrich Keilholz, Saad Khan, Alexander Kiss, Claus-Henning Köhne, Rainer Kunstfeld, Heinz-Josef Lenz, Stuart Lichtman, Lisa Licitra, Thomas Lion, Saskia Litière, Lifang Liu, Patrick J Loehrer, Merry Jennifer Markham, Ben Markman, Marius Mayerhoefer, Johannes G Meran, Olivier Michielin, Elizabeth Charlotte Moser, Giannis Mountzios, Timothy Moynihan, Torsten Nielsen, Yuichiro Ohe, Kjell Öberg, Antonio Palumbo, Fedro Alessandro Peccatori, Michael Pfeilstöcker, Chandrajit Raut, Scot C Remick, Mark Robson, Piotr Rutkowski, Roberto Salgado, Lidia Schapira, Eva Schernhammer, Martin Schlumberger, Hans-Joachim Schmoll, Lowell Schnipper, Cristiana Sessa, Charles L Shapiro, Julie Steele, Cora N Sternberg, Friedrich Stiefel, Florian Strasser, Roger Stupp, Richard Sullivan, Josep Tabernero, Luzia Travado, Marcel Verheij, Emile Voest, Everett Vokes, Jamie Von Roenn, Jeffrey S Weber, Hans Wildiers, Yosef Yarden
The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to provide state-of-the-art cancer care to all patients wherever they live...
2016: ESMO Open
https://www.readbyqxmd.com/read/27829186/counseling-by-epileptologists-affects-contraceptive-choices-of-women-with-epilepsy
#6
Alyssa R Espinera, Jay Gavvala, Irena Bellinski, Jeffrey Kennedy, Micheal P Macken, Aditi Narechania, Jessica Templer, Stephen VanHaerents, Stephan U Schuele, Elizabeth E Gerard
INTRODUCTION: There are several important interactions between antiepileptic drugs (AEDs) and hormonal contraception that need to be carefully considered by women with epilepsy (WWE) and their practitioners. Many AEDs induce hepatic enzymes and decrease the efficacy of hormonal contraception. In addition, estrogen-containing hormonal contraception can increase the metabolism of lamotrigine, the most commonly prescribed AED in women of childbearing age. The intrauterine device (IUD) is a highly effective form of reversible contraception without AED drug interactions that is considered by many to be the contraceptive of choice for WWE...
October 29, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27826660/-evaluation-of-the-decision-aid-entscheidungshilfe-prostatakrebs-from-the-patients-view-results-from-the-first-three-months
#7
C Groeben, A Ihrig, T Hölscher, T Krones, E Kessler, S Kliesch, C Wülfing, R Koch, M P Wirth, J Huber
BACKGROUND: The decision aid "Entscheidungshilfe Prostatakrebs" is available online free of charge since June 2016. It is designed to support patients with their treatment decision-making and to lighten the burden on their treating urologists. This study evaluates usage data from the first 3 months. MATERIALS AND METHODS: The ICHOM standard set was applied to allow a personalised presentation and to collect relevant data for subsequent counselling. Additionally, personal preferences and psychological burden were assessed amongst others...
November 8, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27824776/hopes-and-expectations-regarding-genetic-testing-for-schizophrenia-among-young-adults-at-clinical-high-risk-for-psychosis
#8
Phoebe Friesen, Ryan E Lawrence, Gary Brucato, Ragy R Girgis, Lisa Dixon
Genetic tests for schizophrenia could introduce both risks and benefits. Little is known about the hopes and expectations of young adults at clinical high-risk for psychosis concerning genetic testing for schizophrenia, despite the fact that these youth could be among those highly affected by such tests. We conducted semistructured interviews with 15 young adults at clinical high-risk for psychosis to ask about their interest, expectations, and hopes regarding genetic testing for schizophrenia. Most participants reported a high level of interest in genetic testing for schizophrenia, and the majority said they would take such a test immediately if it were available...
November 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27818719/versailles-project-on-advanced-materials-and-standards-interlaboratory-study-on-measuring-the-thickness-and-chemistry-of-nanoparticle-coatings-using-xps-and-leis
#9
Natalie A Belsey, David J H Cant, Caterina Minelli, Joyce R Araujo, Bernd Bock, Philipp Brüner, David G Castner, Giacomo Ceccone, Jonathan D P Counsell, Paul M Dietrich, Mark H Engelhard, Sarah Fearn, Carlos E Galhardo, Henryk Kalbe, Jeong Won Kim, Luis Lartundo-Rojas, Henry S Luftman, Tim S Nunney, Johannes Pseiner, Emily F Smith, Valentina Spampinato, Jacobus M Sturm, Andrew G Thomas, Jon P W Treacy, Lothar Veith, Michael Wagstaffe, Hai Wang, Meiling Wang, Yung-Chen Wang, Wolfgang Werner, Li Yang, Alexander G Shard
We report the results of a VAMAS (Versailles Project on Advanced Materials and Standards) inter-laboratory study on the measurement of the shell thickness and chemistry of nanoparticle coatings. Peptide-coated gold particles were supplied to laboratories in two forms: a colloidal suspension in pure water and; particles dried onto a silicon wafer. Participants prepared and analyzed these samples using either X-ray photoelectron spectroscopy (XPS) or low energy ion scattering (LEIS). Careful data analysis revealed some significant sources of discrepancy, particularly for XPS...
October 27, 2016: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/27815511/lorcaserin-for-smoking-cessation-and-associated-weight-gain-a-randomized-12-week-clinical-trial
#10
William R Shanahan, Jed E Rose, Alan Glicklich, Scott Stubbe, Matilde Sanchez-Kam
INTRODUCTION: Lorcaserin is a selective serotonin 2C receptor agonist approved by the FDA for chronic weight management. Preclinical data suggest that it may also be effective in smoking cessation through modulation of the dopaminergic reward system. METHODS: This was a 12-week, randomized, double-blind, placebo-controlled trial conducted in 30 centers in the United States. 603 adult smokers with a Body Mass Index (BMI) of 18.5-35 kg/m(2), averaging at least 10 cigarettes/day with no period of abstinence >3 months for the past year were randomized to lorcaserin 10 mg QD, 10 mg BID or placebo; all received standardized smoking cessation counseling weekly...
November 4, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27813606/chromosome-7-translocation-breakpoints-in-male-carriers-clinical-features-and-implications-for-genetic-counseling
#11
R X Wang, H G Zhang, Y Pan, J H Zhu, F G Yue, L T Xue, R Z Liu
Balanced reciprocal translocations are associated with reproductive failure. Some reciprocal translocation carriers exhibit azoospermia or oligozoospermia, and an association exists between these chromosomal abnormalities and recurrent abortion. Previous reports have indicated the involvement of chromosome 7 translocations in male infertility and recurrent miscarriage. A translocation breakpoint can occur within an important gene, interrupting its structure and leading to male infertility. However, clinical characteristics resulting from chromosome 7 translocation breakpoints have not been studied...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27811319/phase-2-study-of-the-safety-and-tolerability-of-maraviroc-containing-regimens-to-prevent-hiv-infection-in-men-who-have-sex-with-men-msm-hptn-069-actg-a5305
#12
Roy M Gulick, Timothy J Wilkin, Ying Q Chen, Raphael J Landovitz, K Rivet Amico, Alicia M Young, Paul Richardson, Mark A Marzinke, Craig W Hendrix, Susan H Eshleman, Ian McGowan, Leslie M Cottle, Adriana Andrade, Cheryl Marcus, Karin L Klingman, Wairimu Chege, Alex R Rinehart, James F Rooney, Philip Andrew, Robert A Salata, Manya Magnus, Jason E Farley, Albert Liu, Ian Frank, Ken Ho, Jorge Santana, Joanne D Stekler, Marybeth McCauley, Kenneth H Mayer
BACKGROUND:  Maraviroc (MVC) is a candidate for HIV pre-exposure prophylaxis (PrEP). METHODS:  Phase 2 48-week safety/tolerability study of four regimens: MVC alone, MVC+emtricitabine (FTC), MVC+tenofovir disoproxil fumarate (TDF), and TDF+FTC. Eligible participants were HIV-uninfected men and transgender women reporting condomless anal intercourse with >1 HIV-infected or unknown-serostatus man within 90 days. At each visit, assessments, laboratory testing, and counseling were done...
November 2, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27807863/prevalence-incidence-and-risk-factors-of-human-immunodeficiency-virus-infection-in-blood-donors-in-the-southeastern-united-states
#13
Lauren A Crowder, Whitney R Steele, Edward P Notari, Courtney K Hopkins, Jose L O Lima, Gregory A Foster, Rebecca L Townsend, David E Krysztof, Roger Y Dodd, Susan L Stramer
BACKGROUND: Human immunodeficiency virus (HIV)-positive blood donors pose a risk to blood safety. The Southeastern United States has the highest reported HIV infection rates. Here we calculate HIV prevalence, incidence, and residual risk in Southeastern US blood donors and report risk factors disclosed by incident donors in counseling sessions. STUDY DESIGN AND METHODS: American Red Cross donation and testing data from 2009 to 2014 for three Southeastern collection regions were used to calculate HIV prevalence, incidence, and residual risk...
November 2, 2016: Transfusion
https://www.readbyqxmd.com/read/27798102/additional-rare-variant-analysis-in-parkinson-s-disease-cases-with-and-without-known-pathogenic-mutations-evidence-for-oligogenic-inheritance
#14
Steven J Lubbe, Valentina Escott-Price, J Raphael Gibbs, Mike A Nalls, Jose Bras, T Ryan Price, Aude Nicolas, Iris E Jansen, Kin Y Mok, Alan M Pittman, James E Tomkins, Patrick A Lewis, Alastair J Noyce, Suzanne Lesage, Manu Sharma, Elena R Schiff, Adam P Levine, Alexis Brice, Thomas Gasser, John Hardy, Peter Heutink, Nicholas W Wood, Andrew B Singleton, Nigel M Williams, Huw R Morris
Oligogenic inheritance implies a role for several genetic factors in disease etiology. We studied oligogenic inheritance in Parkinson's (PD) by assessing the potential burden of additional rare variants in established Mendelian genes and/or GBA, in individuals with and without a primary pathogenic genetic cause in two large independent cohorts totaling 7,900 PD cases and 6,166 controls. An excess (≥30%) of cases with a recognized primary genetic cause had ≥1 additional rare variants in Mendelian PD genes, as compared with no known mutation PD cases (17%) and unaffected controls (16%), supporting our hypothesis...
October 18, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27798042/effectiveness-of-lifestyle-intervention-in-subgroups-of-obese-infertile-women-a-subgroup-analysis-of-a-rct
#15
A M van Oers, H Groen, M A Q Mutsaerts, J M Burggraaff, W K H Kuchenbecker, D A M Perquin, C A M Koks, R van Golde, E M Kaaijk, J M Schierbeek, G J E Oosterhuis, F J Broekmans, N E A Vogel, J A Land, B W J Mol, A Hoek
STUDY QUESTION: Do age, ovulatory status, severity of obesity and body fat distribution affect the effectiveness of lifestyle intervention in obese infertile women? SUMMARY ANSWER: We did not identify a subgroup in which lifestyle intervention increased the healthy live birth rate however it did increase the natural conception rate in anovulatory obese infertile women. WHAT IS KNOWN ALREADY: Obese women are at increased risk of infertility and are less likely to conceive after infertility treatment...
October 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27797978/what-factors-predict-length-of-stay-in-a-neonatal-unit-a-systematic-review
#16
Sarah E Seaton, Lisa Barker, David Jenkins, Elizabeth S Draper, Keith R Abrams, Bradley N Manktelow
OBJECTIVE: In the UK, 1 in 10 babies require specialist neonatal care. This care can last from hours to months depending on the need of the baby. The increasing survival of very preterm babies has increased neonatal care resource use. Evidence from multiple studies is crucial to identify factors which may be important for predicting length of stay (LOS). The ability to predict LOS is vital for resource planning, decision-making and parent counselling. The objective of this review was to identify which factors are important to consider when predicting LOS in the neonatal unit...
October 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27787681/a-nurse-led-sexual-rehabilitation-intervention-after-radiotherapy-for-gynecological-cancer
#17
R M Bakker, J W M Mens, H E de Groot, C C Tuijnman-Raasveld, C Braat, W C P Hompus, J G M Poelman, M S Laman, L A Velema, C D de Kroon, H C van Doorn, C L Creutzberg, M M Ter Kuile
PURPOSE: Although vaginal dilator use after combined pelvic radiation therapy and brachytherapy (RT/BT) is recommended to prevent vaginal shortening and stenosis, women fail to use them and experience sexual problems. A nurse-led sexual rehabilitation intervention targeting sexual recovery and vaginal dilatation was developed. Its feasibility was investigated during a prospective, longitudinal, observational pilot study. METHODS: Four oncology nurses were specifically trained to conduct the intervention...
October 27, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27764232/modelling-neonatal-care-pathways-for-babies-born-preterm-an-application-of-multistate-modelling
#18
Sarah E Seaton, Lisa Barker, Elizabeth S Draper, Keith R Abrams, Neena Modi, Bradley N Manktelow
Modelling length of stay in neonatal care is vital to inform service planning and the counselling of parents. Preterm babies, at the highest risk of mortality, can have long stays in neonatal care and require high resource use. Previous work has incorporated babies that die into length of stay estimates, but this still overlooks the levels of care required during their stay. This work incorporates all babies, and the levels of care they require, into length of stay estimates. Data were obtained from the National Neonatal Research Database for singleton babies born at 24-31 weeks gestational age discharged from a neonatal unit in England from 2011 to 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27747257/the-role-of-gender-affirmation-in-psychological-well-being-among-transgender-women
#19
Tiffany R Glynn, Kristi E Gamarel, Christopher W Kahler, Mariko Iwamoto, Don Operario, Tooru Nemoto
High prevalence of psychological distress, including greater depression, lower self-esteem, and suicidal ideation, has been documented across numerous samples of transgender women and has been attributed to high rates of discrimination and violence. According to the gender affirmation framework (Sevelius, 2013), access to sources of gender-affirmative support can offset such negative psychological effects of social oppression. However, critical questions remain unanswered in regards to how and which aspects of gender affirmation are related to psychological well-being...
September 2016: Psychology of Sexual Orientation and Gender Diversity
https://www.readbyqxmd.com/read/27743698/are-proton-pump-inhibitors-harmful-for-the-semen-quality-of-men-in-couples-who-are-planning-pregnancy
#20
Nicole A Huijgen, Maria A J de Ridder, Katia M Verhamme, Gert R Dohle, Ann M Vanrolleghem, Miriam C J M Sturkenboom, Joop S E Laven, Régine P M Steegers-Theunissen
OBJECTIVE: To determine associations between proton-pump inhibitor (PPI) use and semen parameters in young men of couples who are planning pregnancy. DESIGN: Case-control study of a population-based registry. SETTING: Not applicable. PATIENT(S): General practitioner patients comprising 2,473 men from couples planning pregnancy with a recorded semen analysis: 241 with a low total motile sperm count (TMSC ≤1) and 714 with TMSC >1 as matched controls...
December 2016: Fertility and Sterility
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