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https://www.readbyqxmd.com/read/29341148/outcomes-after-prophylactic-gastrectomy-for-hereditary-diffuse-gastric-cancer
#1
R T van der Kaaij, J P van Kessel, J M van Dieren, P Snaebjornsson, O Balagué, F van Coevorden, L E van der Kolk, K Sikorska, A Cats, J W van Sandick
BACKGROUND: Patients with hereditary diffuse gastric cancer and a CDH1 mutation have a 60-80 per cent lifetime risk of developing diffuse gastric cancer. Total prophylactic gastrectomy eliminates this risk, but is associated with considerable morbidity. The effectiveness (removal of all gastric mucosa) and outcomes of this procedure were evaluated retrospectively. METHODS: All consecutive individuals undergoing a prophylactic gastrectomy for a CDH1 mutation or gastric signet ring cell foci at the authors' institute between 2005 and 2017 were included...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29338539/primary-care-provider-experience-with-breast-density-legislation-in-massachusetts
#2
Christine M Gunn, Nancy R Kressin, Kristina Cooper, Cinthya Marturano, Karen M Freund, Tracy A Battaglia
BACKGROUND: Dense breasts on mammography independently increases breast cancer risk and decreases mammography sensitivity. Thirty-two states have adopted notification laws to raise awareness among women with dense breasts about supplemental screening. Little is known about these policies' impact on clinical practice among primary care providers (PCPs). MATERIALS AND METHODS: This study explores PCP attitudes, knowledge, and the impact of the Massachusetts dense breast notification legislation on clinical practice after its enactment in 2015...
January 17, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29302687/breast-implants-and-the-risk-of-anaplastic-large-cell-lymphoma-in-the-breast
#3
Mintsje de Boer, Flora E van Leeuwen, Michael Hauptmann, Lucy I H Overbeek, Jan Paul de Boer, Nathalie J Hijmering, Arthur Sernee, Caroline A H Klazen, Marc B I Lobbes, René R W J van der Hulst, Hinne A Rakhorst, Daphne de Jong
Importance: Breast implants are among the most commonly used medical devices. Since 2008, the number of women with breast implants diagnosed with anaplastic large-cell lymphoma in the breast (breast-ALCL) has increased, and several reports have suggested an association between breast implants and risk of breast-ALCL. However, relative and absolute risks of breast-ALCL in women with implants are still unknown, precluding evidence-based counseling about implants. Objective: To determine relative and absolute risks of breast-ALCL in women with breast implants...
January 4, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29276777/patient-centered-dentinal-hypersensitivity-treatment-outcomes-results-from-the-national-dental-pbrn
#4
M W Heft, M S Litaker, D T Kopycka-Kedzierawski, C Meyerowitz, S Chonowski, R L Yardic, V V Gordan, R Mungia, G H Gilbert
Dentinal hypersensitivity (DH) can have a significant impact on oral health and functioning, and it is a clinical symptom commonly managed by dentists during routine clinical practice. DH symptoms are typically elicited by otherwise innocuous, nonpainful stimuli applied to exposed dentin (e.g., tactile stimuli, warming or cooling temperatures or air puffs). Treatment approaches have sought to directly target the dentinal pulp tissues or close dentinal tubules via dental office care and treatment services (fluoride varnishes, glutaraldehydes, bonding agents, sealants, oxalates, or lasers) or home care services (toothpastes or dentifrices containing fluoride or potassium nitrate compounds)...
January 2018: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/29274894/the-physical-activity-daily-pad-trial-the-rationale-and-design-of-a-randomized-controlled-trial-evaluating-an-internet-walking-program-to-improve-maximal-walking-distance-among-patients-with-peripheral-arterial-disease
#5
Anjana M Kumar, Angela K Lyden, Noelle E Carlozzi, Ananda Sen, Caroline R Richardson, Elizabeth A Jackson
BACKGROUND: Despite established guidelines for regular walking as a first line therapy for adults with peripheral arterial disease (PAD), most patients do not walk routinely. This paper presents the design specifications for a randomized clinical trial to examine the effectiveness of an internet-based walking program compared to a telephone intervention, or the combination (internet-based with telephone counseling) for promotion of regular walking in patients with PAD. METHODS: Sedentary adults with documented lower extremity PAD are being recruited from the University of Michigan Health System and the surrounding area...
December 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29274027/chemotherapy-and-echocardiographic-indices-in-patients-with-non-hodgkin-lymphoma-the-onco-echo-study
#6
Katarzyna Mizia-Stec, Marek Elżbieciak, Maciej T Wybraniec, Monika Różewicz, Artur Bodys, Wojciech Braksator, Zbigniew Gąsior, Piotr Gościniak, Tomasz Hryniewiecki, Jarosław Kasprzak, Andrzej Wojtarowicz, Barbara Zdziarska, Edyta Płońska-Gościniak
The cardiotoxicity of chemotherapy (CTx) for non-Hodgkin's lymphomas is not well recognized. In order to facilitate individual risk counseling for patients, we analyzed the effect of CTx on echocardiographic indices in regard to clinical data in patients treated for non-Hodgkin's lymphoma (NHL). A prospective multicenter ONCO-ECHO trial included 67 patients with NHL (45 patients with DLBCL (diffuse large B cell lymphoma) and 22 with non-DLBCL). Patients received standard CTx, primarily R-CHOP, CHOP, R-COP and COP regimens...
December 22, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29248774/presenting-symptoms-and-prognostic-factors-for-symptomatic-outcomes-following-resection-of-meningioma
#7
Ashley Wu, Michael A Garcia, Stephen T Magill, William Chen, Harish N Vasudevan, Arie Perry, Philip V Theodosopoulos, Michael W McDermott, Steve E Braunstein, David R Raleigh
BACKGROUND: Meningioma is the most common primary intracranial tumor and patients present with diverse neurologic symptoms related to meningioma location. OBJECTIVE: To systematically quantify the presenting symptoms of meningioma and identify prognostic factors for symptomatic outcome following resection. METHODS: Two-hundred eighty-three patients who underwent resection of 313 meningiomas at a single institution were retrospectively identified, including 161 WHO grade I (52...
December 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29242113/professionals-knowledge-attitude-and-referral-behaviour-of-preimplantation-genetic-diagnosis-for-hereditary-breast-and-ovarian-cancer
#8
J J G Gietel-Habets, C E M de Die-Smulders, V C G Tjan-Heijnen, I A P Derks-Smeets, R van Golde, E Gomez-Garcia, L A D M van Osch
Hereditary breast and ovarian cancer caused by a BRCA1/2 mutation is the most frequent indication for preimplantation genetic diagnosis (PGD) in the Netherlands. The extent to which involved professionals are informed about this option, however, is unclear. The few available international studies mostly represent a limited range of professionals, and suggest that their knowledge about PGD for hereditary cancer syndromes is sparse and referral for PGD is based on limited understanding. A cross-sectional survey assessing awareness, knowledge, acceptability and PGD-referral for BRCA was completed by 188 professionals involved in the field of breast and ovarian cancer or reproduction...
December 6, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29241717/provider-discussions-of-genetic-tests-with-u-s-women-at-risk-for-a-brca-mutation
#9
Leland E Hull, Jennifer S Haas, Steven R Simon
INTRODUCTION: The U.S. Preventive Services Task Force recommends that primary care providers screen unaffected women with a family history of BRCA mutation-associated cancers, but without a personal history of BRCA-related cancer, for referral to genetic counseling and potential genetic testing. METHODS: The 2015 National Health Interview Survey was analyzed in January 2017 to determine the rates at which unaffected adult women with a positive family history of BRCA-related cancers, assessed using the Family History Screen-7, reported discussing genetic testing with a provider, using genetic counseling services, and having genetic testing for increased cancer risk...
December 11, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29236593/role-of-genetic-testing-for-inherited-prostate-cancer-risk-philadelphia-prostate-cancer-consensus-conference-2017
#10
Veda N Giri, Karen E Knudsen, William K Kelly, Wassim Abida, Gerald L Andriole, Chris H Bangma, Justin E Bekelman, Mitchell C Benson, Amie Blanco, Arthur Burnett, William J Catalona, Kathleen A Cooney, Matthew Cooperberg, David E Crawford, Robert B Den, Adam P Dicker, Scott Eggener, Neil Fleshner, Matthew L Freedman, Freddie C Hamdy, Jean Hoffman-Censits, Mark D Hurwitz, Colette Hyatt, William B Isaacs, Christopher J Kane, Philip Kantoff, R Jeffrey Karnes, Lawrence I Karsh, Eric A Klein, Daniel W Lin, Kevin R Loughlin, Grace Lu-Yao, S Bruce Malkowicz, Mark J Mann, James R Mark, Peter A McCue, Martin M Miner, Todd Morgan, Judd W Moul, Ronald E Myers, Sarah M Nielsen, Elias Obeid, Christian P Pavlovich, Stephen C Peiper, David F Penson, Daniel Petrylak, Curtis A Pettaway, Robert Pilarski, Peter A Pinto, Wendy Poage, Ganesh V Raj, Timothy R Rebbeck, Mark E Robson, Matt T Rosenberg, Howard Sandler, Oliver Sartor, Edward Schaeffer, Gordon F Schwartz, Mark S Shahin, Neal D Shore, Brian Shuch, Howard R Soule, Scott A Tomlins, Edouard J Trabulsi, Robert Uzzo, Donald J Vander Griend, Patrick C Walsh, Carol J Weil, Richard Wender, Leonard G Gomella
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing...
December 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29233395/knowledge-attitudes-and-beliefs-regarding-human-immunodeficiency-virus-and-in-home-testing-among-a-regional-sample-of-student-pharmacists
#11
Alvina Tran, Autumn L Stewart, Jordan R Covvey
INTRODUCTION: Pharmacists identify the importance of education on human immunodeficiency virus (HIV); however, research suggests deficits in knowledge regarding recommendations and testing devices. With proper training, student pharmacists can play an important role in counseling patients on the importance of HIV testing and providing instruction on in-home testing. The objective of the study was to assess student pharmacists' knowledge, attitudes and beliefs of HIV and the use of an in-home, over-the-counter HIV testing device...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29223750/choosing-pre-conception-planning-for-women-families-counselling-and-informed-consent-part-2-pre-conception-reproductive-planning-lifestyle-immunization-and-psychosocial-issues
#12
REVIEW
R Douglas Wilson
OBJECTIVE: To inform reproductive and other health care providers about pre-conception evaluation, including considerations for reproductive planning, lifestyle modification, immunization status and attitudes, and psychosocial issues. OPTIONS: This counselling information can be used for patient education and planning and possible pre-conception and/or prenatal testing. OUTCOMES: This information may allow for improved risk assessment when pre-conception counselling for individual patients and their families is used...
December 6, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29215523/ethical-considerations-concerning-amnioinfusions-for-treating-fetal-bilateral-renal-agenesis
#13
REVIEW
Jeremy Sugarman, Jean Anderson, Ahmet A Baschat, Jaime Herrera Beutler, Jessica L Bienstock, Timothy E Bunchman, Niraj M Desai, Elena Gates, Aviva Goldberg, Paul C Grimm, Leslie Meltzer Henry, Eric B Jelin, Emily Johnson, Christine B Hertenstein, Anna C Mastroianni, Mark R Mercurio, Alicia Neu, Lawrence M Nogee, William J Polzin, Steven J Ralston, Ronald M Ramus, Megan Kasimatis Singleton, Michael J G Somers, Karen C Wang, Renee Boss
Congenital bilateral renal agenesis has been considered a uniformly fatal condition. However, the report of using serial amnioinfusions followed by the live birth in 2012 and ongoing survival of a child with bilateral renal agenesis has generated hope, but also considerable controversy over an array of complex clinical and ethical concerns. To assess the ethical concerns associated with using serial amnioinfusions for bilateral renal agenesis, we assembled a multidisciplinary group to map the ethical issues relevant to this novel intervention...
January 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29204183/evaluation-of-outcomes-for-psychosis-and-epilepsy-treatment-delivered-by-primary-health-care-workers-in-nepal-a-cohort-study
#14
M J D Jordans, L Aldridge, N P Luitel, F Baingana, B A Kohrt
Background: Most evaluations of task-shifting have focused on common mental disorders. Much less work has been done on severe mental neurological and substance use (MNS) disorders, such as chronic psychosis and epilepsy. Given the high burden associated with severe MNS and the lack of mental health professionals in low and middle income countries, evaluations on the impact of task-shifting for these disorders are important. Methods: In a rural district of Nepal, a community mental health program, based on World Health Organization's Mental Health Gap Action Programme guidelines, was evaluated using a cohort study design...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29202445/balancing-the-benefits-and-harms-of-thyroid-cancer-surveillance-in-survivors-of-childhood-adolescent-and-young-adult-cancer-recommendations-from-the-international-late-effects-of-childhood-cancer-guideline-harmonization-group-in-collaboration-with-the-pancaresurfup
#15
REVIEW
S C Clement, L C M Kremer, F A Verburg, J H Simmons, M Goldfarb, R P Peeters, E K Alexander, E Bardi, E Brignardello, L S Constine, C A Dinauer, V M Drozd, F Felicetti, E Frey, A Heinzel, M M van den Heuvel-Eibrink, S A Huang, T P Links, K Lorenz, R L Mulder, S J Neggers, E J M Nieveen van Dijkum, K C Oeffinger, R R van Rijn, S A Rivkees, C M Ronckers, A B Schneider, R Skinner, J D Wasserman, T Wynn, M M Hudson, P C Nathan, H M van Santen
Radiation exposure to the thyroid gland during treatment of childhood, adolescent and young adult cancer (CAYAC) may cause differentiated thyroid cancer (DTC). Surveillance recommendations for DTC vary considerably, causing uncertainty about optimum screening practices. The International Late Effects of Childhood Cancer Guideline Harmonization Group, in collaboration with the PanCareSurFup Consortium, developed consensus recommendations for thyroid cancer surveillance in CAYAC survivors. These recommendations were developed by an international multidisciplinary panel that included 33 experts in relevant medical specialties who used a consistent and transparent process...
November 14, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29193313/estimating-the-number-of-potential-family-members-eligible-for-brca1-and-brca2-mutation-testing-in-a-traceback-approach
#16
Haley A Moss, Goli Samimi, Laura J Havrilesky, Mark E Sherman, Evan R Myers
U.S. guidelines recommend BRCA1/2 mutation testing for women diagnosed with high-grade ovarian cancer (HGOC) to increase recognition of carriers, but most remain unidentified and at risk. Accordingly, an approach termed "Traceback" has been proposed in which probands are retrospectively identified by testing archived pathology specimens, and family members are traced to provide genetic counseling and testing. We used population-based data to estimate the number of family members who might be contacted through such a program...
November 30, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/29179734/an-integrated-digital-clinical-approach-to-smoking-cessation-in-lung-cancer-screening-study-protocol-for-a-randomized-controlled-trial
#17
Amanda L Graham, Michael V Burke, Megan A Jacobs, Sarah Cha, Ivana T Croghan, Darrell R Schroeder, James P Moriarty, Bijan J Borah, Donna F Rasmussen, M Jody Brookover, Dale B Suesse, David E Midthun, J Taylor Hays
BACKGROUND: Delivering effective tobacco dependence treatment that is feasible within lung cancer screening (LCS) programs is crucial for realizing the health benefits and cost savings of screening. Large-scale trials and systematic reviews have demonstrated that digital cessation interventions (i.e. web-based and text message) are effective, sustainable over the long-term, scalable, and cost-efficient. Use of digital technologies is commonplace among older adults, making this a feasible approach within LCS programs...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29174388/smokers-identity-and-quit-advice-in-general-practice-general-practitioners-need-to-focus-more-on-female-smokers
#18
Eline Meijer, Marjolein E A Verbiest, Niels H Chavannes, Ad A Kaptein, Willem J J Assendelft, Margreet Scharloo, Mathilde R Crone
OBJECTIVE: We examined smoker and non-smoker self-identities among smokers visiting their general practitioner (GP) for other reasons than smoking cessation counselling. We determined whether identity impacted on patients' appreciation of GP-initiated conversations about smoking and quit advice, and subsequent quit attempts, and examined the role of gender. METHODS: Secondary analyses of a cluster-randomised controlled trial in which baseline and 12-month follow-up data were collected among 527 daily (n=450) and non-daily smokers (n=77)...
November 17, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29171296/the-support-health-activities-resources-and-education-program-for-early-stage-dementia-results-from-a-randomized-controlled-trial
#19
Carol J Whitlatch, Allison R Heid, Elia E Femia, Silvia Orsulic-Jeras, Sarah Szabo, Steven H Zarit
Purpose A randomized controlled trial was conducted to test the effectiveness of the Support, Health, Activities, Resources, and Education Program. This six-session psycho-educational program provides dyadic counseling for individuals in the early stages of dementia and their family caregivers. The goal is to prevent common problems in care that emerge during the course of dementia by (1) actively engaging the person with dementia in developing a balanced plan of future care with his/her caregiver, (2) increasing use of available services, (3) enhancing dyadic relationship functioning, (4) improving well-being, and (5) evoking satisfaction with components of the intervention...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29162078/a-tailored-counseling-and-home-based-rehabilitation-program-to-increase-physical-activity-and-improve-mobility-among-community-dwelling-older-people-after-hospitalization-protocol-of-a-randomized-controlled-trial
#20
K Turunen, L Aaltonen, J Kumpumäki, E Portegijs, S Keikkala, M-L Kinnunen, T Finni, S Sipilä, R Nikander
BACKGROUND: Physical activity (PA) decreases during hospitalization. In particular, the amount of PA engaged in by older people who are hospitalized following musculoskeletal injury is likely to be limited for months after discharge home. Given the importance of an active lifestyle for their recovery and the prevention of future adverse outcomes, there is clearly a need for interventions to increase PA. This article describes the protocol of a randomized controlled trial set up to investigate the effects of a physical activity oriented home rehabilitation program (ProPA) on PA and the restoration of mobility in community-dwelling older people...
November 21, 2017: BMC Musculoskeletal Disorders
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