keyword
MENU ▼
Read by QxMD icon Read
search

NGF, serum, Alzheimer, Parkinson.

keyword
https://www.readbyqxmd.com/read/27465784/discovery-of-neurotrophic-agents-based-on-hydroxycinnamic-acid-scaffold
#1
Razieh Hosseini, Fatemeh Moosavi, Hamid Rajaian, Tiago Silva, Diogo Magalhães E Silva, Pedro Soares, Luciano Saso, Najmeh Edraki, Ramin Miri, Fernanda Borges, Omidreza Firuzi
The number of people affected by neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease is rapidly increasing owing to the global increase in life expectancy. Small molecules with neurotrophic effects have great potential for management of these neurological disorders. In this study, different (C1-C12) alkyl ester derivatives of hydroxycinnamic acids (HCAs) were synthesized (a total of 30 compounds). The neurotrophic capacity of the test compounds was examined by measuring promotion of survival in serum-deprived conditions and enhancement of nerve growth factor (NGF)-induced neurite outgrowth in PC12 neuronal cells...
July 28, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/16313102/-endogenous-factors-regulating-neuronal-apoptosis
#2
REVIEW
Akinori Akaike, Hiroshi Katsuki, Toshiaki Kume
Apoptosis and necrosis of neurons induced by glutamate and nitric oxide (NO) are associated with various disorders including hypoxic-ischemic brain injury, Alzheimer's disease and Parkinson's disease. In search of endogenous protective factors that inhibit NO-mediated glutamate neurotoxicity, we found that excitotoxicity is suppressed by certain neurotransmitters such as nicotinic acetylcholine and dopamine and growth factors such as NGF and BDNF. We recently purified and isolated a novel neuroprotective substance, which has been named 'serofendic acid', from a lipophilic fraction of fetal calf serum...
October 2005: Nihon Shinkei Seishin Yakurigaku Zasshi, Japanese Journal of Psychopharmacology
https://www.readbyqxmd.com/read/15967377/from-clinical-evidence-to-molecular-mechanisms-underlying-neuroprotection-afforded-by-estrogens
#3
REVIEW
Diana Amantea, Rossella Russo, Giacinto Bagetta, Maria Tiziana Corasaniti
Recent studies have highlighted that female sex hormones represent potential neuroprotective agents against damage produced by acute and chronic injuries in the adult brain. Clinical reports have documented the effectiveness of estrogens to attenuate symptoms associated with Parkinson's disease, and to reduce the risk of Alzheimer's disease and cerebrovascular stroke. This evidence is corroborated by numerous experimental studies documenting the protective role of female sex hormones both in vitro and in vivo...
August 2005: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/11462801/the-anti-parkinson-drug-rasagiline-and-its-cholinesterase-inhibitor-derivatives-exert-neuroprotection-unrelated-to-mao-inhibition-in-cell-culture-and-in-vivo
#4
M B Youdim, A Wadia, W Tatton, M Weinstock
The antiapoptotic and neuroprotective activity of irreversible monoamine oxidase (MAO) B inhibitor, rasagiline [R(+)-N-propargyl-1-aminioindan], its S-isomer (TVP1022) and TV 3219, a novel anti-Alzheimer cholinesterase-MAO inhibitor drug derived from rasagiline were examined in PC12 cells cultures and in vivo. We found that these drugs have potent antiapoptotic and neuroprotective activities in response to serum and NGF withdrawal in partially neuronally differentiated PC12 cells and prevent the fall in mitochondrial membrane potential, the first step in cell death...
June 2001: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/9634658/-nerve-growth-factor-and-neurological-diseases
#5
COMPARATIVE STUDY
L Lorigados, N Pavón, T Serrano, M A Robinson
INTRODUCTION: The effects of Nerve Growth Factor (NGF) within and outside the nervous system have been amply discussed in recent decades. Recently clinical studies have shown the effectiveness of this growth factor in the treatment of neurodegenerative disorders. This clinical use makes it necessary to have sensitive, specific methods available to permit measurement of the level of this protein and to determine how it behaves during the course of treatment. OBJECTIVE: To describe the measurement of NGF levels in human serum using an immunoenzymatic method and evaluating the levels of this protein in some neurological disorders...
May 1998: Revista de Neurologia
https://www.readbyqxmd.com/read/7596217/lack-of-protective-effect-of-r-deprenyl-on-programmed-cell-death-of-mouse-thymocytes-induced-by-dexamethasone
#6
J Fang, D M Zuo, P H Yu
R(-)-Deprenyl, an archetypical MAO-B inhibitor, has been shown to delay the onset of the disabling syndrome of Parkinson's disease and to be useful in the treatment of Alzheimer's disease. Recently, R(-)-deprenyl has been claimed to be capable of preventing apoptosis of PC12 cells, which had been primed with nerve growth factor (NGF) and followed by withdrawal of serum. We investigated the effect of R(-)-deprenyl in a non-neuronal cell model, namely, apoptosis of mouse thymocytes induced by dexamethasone. Trypan blue exclusion and lactate dehydrogenase activity were applied to assess the cell survival...
1995: Life Sciences
https://www.readbyqxmd.com/read/1433383/two-site-enzyme-immunoassay-for-beta-ngf-applied-to-human-patient-sera
#7
L Lorigados, S Söderström, T Ebendal
Nerve growth factor (NGF) supports sympathetic and sensory neurons in the peripheral nervous system and serves functions in the development and maintenance of cholinergic neurons in the basal forebrain. NGF distribution can be studied with the use of a sensitive two-site enzyme immunoassay (EIA). The monoclonal antibody 27/21 to mouse NGF was recently shown to effectively block the activity of both recombinant human NGF and native mouse NGF, and a two-site EIA using monoclonal antibody 27/21 was optimized. We have now applied this assay to examine NGF levels in normal human serum and serum from Parkinson, Alzheimer, and Huntington patients...
July 1992: Journal of Neuroscience Research
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"