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Analucia A Alegria, Joaquim Radua, Katya Rubia
OBJECTIVE: Functional magnetic resonance imaging (fMRI) studies in conduct disorder and in oppositional defiant disorder have shown inconsistencies. The aim of this meta-analysis of fMRI studies in disruptive behavior disorders was to establish the most consistent brain dysfunctions and to address task- and subtype-related heterogeneity. METHOD: Web-based publication databases were searched to conduct a meta-analysis of all whole-brain fMRI studies of youths with disruptive behavior disorder or conduct problems up to August 2015...
August 13, 2016: American Journal of Psychiatry
Maria Emília L Monteiro, Analucia R Xavier, Felipe L Oliveira, Porphirio Js Filho, Vilma B Azeredo
AIM: To determine whether high-protein, high-fat, and low-carbohydrate diets can cause lesions in rat livers. METHODS: We randomly divided 20 female Wistar rats into a control diet group and an experimental diet group. Animals in the control group received an AIN-93M diet, and animals in the experimental group received an Atkins-based diet (59.46% protein, 31.77% fat, and 8.77% carbohydrate). After 8 wk, the rats were anesthetized and exsanguinated for transaminases analysis, and their livers were removed for flow cytometry, immunohistochemistry, and light microscopy studies...
June 14, 2016: World Journal of Gastroenterology: WJG
Clarice Siqueira Silva, Cyro Teixeira da Silva Junior, Bruna Soares Ferreira, Francielle Dal Mora da Silva, Patricia Siqueira Silva, Analúcia Rampazzo Xavier
INTRODUCTION: The nutritional profile of the Brazilian population has changed in recent years. Therefore, this study aimed to assess the prevalence of nutritional status among Brazilian school adolescents during the period from January 2014 to December 2014. METHODS: This study employed an observational design with a cohort of school adolescents. Anthropometric measurement was assessed by nutritionists in government schools. The cut-off points for body mass index according to Brazilian criteria for adolescents of both sexes between 10 years and 19 years old were underweight (≤17...
March 2016: Indian Journal of Endocrinology and Metabolism
Gabriel Costa Serrão de Araújo, Natália Teixeira Mourão, Igor Natário Pinheiro, Analúcia Rampazzo Xavier, Vinicius Schott Gameiro
BACKGROUND: Gunshot wounds require surgeons to decide whether to remove or leave bullet fragments in the body. Surgeons also decide how to follow up with patients who have lead fragments retained in their body. Current literature recommends to remove only intra-articular fragments without the need for a follow-up for patients with the metal retained. Therefore, this study investigates chronic lead toxicity for gunshot wounds. METHODS: The study was performed in the metropolitan area of Rio de Janeiro/Brazil, between 2013 and 2015...
2015: PloS One
Adriana Carvalho-Santos, Marcelo Ribeiro-Alves, Luciene Carvalho Cardoso-Weide, Joyce Nunes, Lia Rafaella Ballard Kuhnert, Analucia Rampazzo Xavier, Samuel Cunha, Michael Hahne, Déa Maria Serra Villa-Verde, Carla Eponina Carvalho-Pinto
Diabetes mellitus is a chronic disease that affects over 382 million people worldwide. Type-1 Diabetes (T1D) is classified as an autoimmune disease that results from pancreatic β-cell destruction and insulin deficiency. Type-2 Diabetes (T2D) is characterized principally by insulin resistance in target tissues followed by decreased insulin production due to β-cell failure. It is challenging to identify immunological markers such as inflammatory molecules that are triggered in response to changes during the pathogenesis of diabetes...
2015: PloS One
Humberto Villacorta, Rochele Alberto Martins Santos, Marcelle Alves Baco Marroig, Guilherme Pinella Guedes Pereira, Analucia Rampazzo Xavier, Salim Kanaan
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of kidney injury. We sought to assess the prognostic value of this biomarker in patients with stable chronic heart failure (HF). METHODS: We studied 61 patients with chronic systolic HF who had been receiving optimal medical treatment for at least six months. Biomarkers were measured at baseline and included plasma NGAL, microalbuminuria, serum creatinine, and B-type natriuretic peptide (BNP)...
July 2015: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Veronique Etienne, Erik C Andersen, José Miguel Ponciano, Dustin Blanton, Analucia Cadavid, Joanna Joyner-Matos, Chikako Matsuba, Brandon Tabman, Charles F Baer
Understanding the genetic basis of susceptibility to pathogens is an important goal of medicine and of evolutionary biology. A key first step toward understanding the genetics and evolution of any phenotypic trait is characterizing the role of mutation. However, the rate at which mutation introduces genetic variance for pathogen susceptibility in any organism is essentially unknown. Here, we quantify the per-generation input of genetic variance by mutation (VM) for susceptibility of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa (defined as the median time of death, LT50)...
February 2015: Evolution; International Journal of Organic Evolution
André M Japiassú, Haroldo Falcão, Fernando Freitas, Sandra Freitas, Paulo César P Souza, Roberto Lannes, Ricardo I Sato, Analucia M Dias, Gustavo F Almeida, Márcio Soares, Jorge I Salluh
BACKGROUND AND OBJECTIVES: The adverse effects of intra-abdominal hypertension are known for many years. Only recently proper attention has been given to routine intra-abdominal pressure (IAP) monitoring. There is evidence that a quarter of intensive care units (ICU) do not measure IAP, due to a lack of knowledge of its importance or difficulty in results interpretation. The aim of this study is investigate the knowledge of ICU physicians about abdominal compartimental syndrome and its management...
June 2007: Revista Brasileira de Terapia Intensiva
Katya Rubia, Analucía A Alegría, Helen Brinson
AIM: To review the magnetic resonance imaging findings in child and adult attention-deficit hyperactivity disorder (ADHD). DEVELOPMENT: Studies have shown that ADHD is characterised by multiple functional and structural neural network abnormalities including most prominently fronto-striatal, but also fronto-parieto-temporal, fronto-cerebellar and even fronto-limbic networks. Evidence from longitudinal structural imaging studies has shown that ADHD is characterised by a delay in structural brain maturation...
February 24, 2014: Revista de Neurologia
Analúcia Ferreira Marangoni, Camila Haddad Leal de Godoy, Daniela Aparecida Biasotto-Gonzalez, Thays Almeida Alfaya, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori
The aim of the present study was determine the type of bite and abnormalities in the vertical dimension of occlusion (VDO) among children and adolescents with temporomandibular disorder (TMD). The Helkimo index was employed for the diagnostic investigation of TMD. A clinical examination was performed for the determination of occlusion. The VDO was measured using a digital caliper. Fisher's exact text was used to determine associations between type of bite, gender and TMD. The Student's t-test was used to compare age and VDO by gender...
July 2014: Journal of Bodywork and Movement Therapies
Katya Rubia, Analucia Alegria, Helen Brinson
A plethora of magnetic resonance imaging studies have shown that ADHD is characterized by multiple functional and structural neural network abnormalities beyond the classical fronto-striatal model, including fronto-parieto-temporal, fronto-cerebellar and even fronto-limbic networks. There is evidence for a maturational delay in brain structure development which likely extends to brain function and structural and functional connectivity, but this needs corroboration by longitudinal imaging studies. Dysfunction of the ventrolateral prefrontal cortex seems to be more pronounced relative to other pediatric disorders and is also the most consistent target of acute psychostimulant medication...
May 2014: Expert Review of Neurotherapeutics
Katya Rubia, Analucia A Alegria, Ana I Cubillo, Anna B Smith, Michael J Brammer, Joaquim Radua
BACKGROUND: Psychostimulant medication, most commonly the catecholamine agonist methylphenidate, is the most effective treatment for attention-deficit/hyperactivity disorder (ADHD). However, relatively little is known on the mechanisms of action. Acute effects on brain function can elucidate underlying neurocognitive effects. We tested methylphenidate effects relative to placebo in functional magnetic resonance imaging (fMRI) during three disorder-relevant tasks in medication-naïve ADHD adolescents...
October 15, 2014: Biological Psychiatry
Analucia V Fantin, Daniel P Willemann, Matias R Viotti, Armando Albertazzi
Shearography is an optical and nondestructive technique that has been largely used for damage detection in layered composite materials where delaminations and debondings are found to be among the most common flaws. Shearography detects derivative of the displacements. It is a relative measurement in which two images are recorded for different loading conditions of the sample. The applied loading induces some deformations into the sample, generating a displacement field on its surface. Thermal, acoustical, or mechanical loading are typical excitations applied in a static or dynamic way...
August 1, 2013: Applied Optics
Jose M Montes, Analucía Alegria, Aurelio Garcia-Lopez, Elena Ezquiaga, Vicent Balanzá-Martínez, Pilar Sierra, Francisco Toledo, Carmen Alcaraz, Josefina Perez, Consuelo de Dios
The aim of this study was to examine the demographic, clinical, and treatment correlates of bipolar disorder (BD) in outpatients 65 years or older and to compare patients with BD subtype I (BD-I) versus BD subtype II (BD-II) and patients with early onset (EO; <=50 years old) versus late onset (LO; >50 years old) of the illness. Sixty-nine consecutive outpatients with BD were included. Diagnosis was delayed for a mean of 14.1 years, significantly longer in patients with EO (18.6 years) than with LO (3...
August 2013: Journal of Nervous and Mental Disease
Analucia A Alegria, Carlos Blanco, Nancy M Petry, Andrew E Skodol, Shang-Min Liu, Bridget Grant, Deborah Hasin
Despite the 3:1 prevalence ratio of men versus women with Antisocial Personality Disorder (ASPD), research on sex differences on correlates of ASPD in the general population is scarce. The purpose of this study was to examine sex differences in childhood and adult adverse events, lifetime psychiatric comorbidity, and clinical correlates of DSM-IV ASPD. The sample included 819 men and 407 women with DSM-IV ASPD diagnosis. Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (N = 43,093)...
July 2013: Personality Disorders
Carla Torrent, Caterina del Mar Bonnin, Anabel Martínez-Arán, Jesús Valle, Benedikt L Amann, Ana González-Pinto, José Manuel Crespo, Ángela Ibáñez, Mari Paz Garcia-Portilla, Rafael Tabarés-Seisdedos, Celso Arango, Francesc Colom, Brisa Solé, Isabella Pacchiarotti, Adriane R Rosa, Jose Luis Ayuso-Mateos, Celia Anaya, Patricia Fernández, Ramon Landín-Romero, Silvia Alonso-Lana, Jordi Ortiz-Gil, Bàrbara Segura, Sara Barbeito, Patricia Vega, Miryam Fernández, Amaia Ugarte, Marta Subirà, Ester Cerrillo, Núria Custal, José Manuel Menchón, Jerónimo Saiz-Ruiz, Jose Maria Rodao, Sandra Isella, Analucía Alegría, Susana Al-Halabi, Julio Bobes, Gonzalo Galván, Pilar A Saiz, Vicent Balanzá-Martínez, Gabriel Selva, Inmaculada Fuentes-Durá, Patricia Correa, María Mayoral, Guadalupe Chiclana, Jessica Merchan-Naranjo, Marta Rapado-Castro, Manel Salamero, Eduard Vieta
OBJECTIVE The authors sought to assess the efficacy of functional remediation, a novel intervention program, on functional improvement in a sample of euthymic patients with bipolar disorder. METHOD In a multicenter, randomized, rater-blind clinical trial involving 239 outpatients with DSM-IV bipolar disorder, functional remediation (N=77) was compared with psychoeducation (N=82) and treatment as usual (N=80) over 21 weeks. Pharmacological treatment was kept stable in all three groups. The primary outcome measure was improvement in global psychosocial functioning, measured blindly as the mean change in score on the Functioning Assessment Short Test from baseline to endpoint...
August 2013: American Journal of Psychiatry
Jerónimo Saiz-Ruiz, M Dolores Saiz-González, Analucía A Alegría, Esperanza Mena, Julia Luque, Julio Bobes
INTRODUCTION: This study evaluates the physical health of patients with schizophrenia and analyzes the change in the percentage of patients with evaluations in the known diabetes and cardiovascular risk predictors before and 6 months after the dissemination of the "Consensus on Physical Health in Schizophrenia Patients". MATERIAL AND METHODS: This is an epidemiological non-interventional and transversal study, in which 229 psychiatrists evaluated 1,193 clinical records of patients with a diagnose of schizophrenia according to ICD-10, attended in the psychiatry consultations planned in January and September of 2007...
October 2010: Revista de Psiquiatrí́a y Salud Mental
Gedson Rodrigues de Morais Lima, Camila de Albuquerque Montenegro, Heloina de Sousa Falcão, Neyres Zínea Taveira de Jesus, Analúcia Guedes Silveira Cabral, Isis Fernandes Gomes, Maria de Fátima Agra, Josean Fechine Tavares, Leônia Maria Batista
Combretum duarteanum Cambess. is found in South America, particularly in Bolivia, Paraguay, and Brazil. In Paraiba state (Brazil), the species usually occurs in the Caatinga biome. It is popularly known as mofumbo, cipiúba, or cipaúba. This work aims to evaluate the gastroprotective activity and the cytoprotective mechanisms of the ethanolic extract (Cd-EtOHE) and hexane phase (Cd-HexP) obtained from the leaves of C. duarteanum. Doses at 62.5, 125, 250, and 500 mg/kg of Cd-EtOHE and Cd-HexP were tested in models of gastric ulcers induced by HCl/ethanol, absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation in male rats or mice...
July 2013: Journal of Natural Medicines
Gedson Rodrigues de Morais Lima, Igor Rafael Praxedes de Sales, Marcelo Ricardo Dutra Caldas Filho, Neyres Zínia Taveira de Jesus, Heloina de Sousa Falcão, José Maria Barbosa-Filho, Analúcia Guedes Silveira Cabral, Augusto Lopes Souto, Josean Fechine Tavares, Leônia Maria Batista
The Combretaceae is a large family of herbs, shrubs and trees, comprising about 20 genera and 600 species with tropical distribution around the globe and centers of diversity in Africa and Asia. Some Combretum species are extensively used in traditional medicine against inflammation, infections, diabetes, malaria, bleeding, diarrhea and digestive disorders and others as a diuretic. The present work is a literature survey of Combretum species that have been evaluated for their ability to exert biological activities...
2012: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Elena Ezquiaga, Aurelio García-López, Jose Manuel Montes, Analucía Alegría, Consuelo de Dios, Vicente Balanzá, Pilar Sierra, Josefina Perez, Francisco Toledo, Alfonso Rodriguez
INTRODUCTION: Studies on adult bipolar patients have demonstrated a disability associated with the bipolar disorder, even in euthymic patients, but there is a lack of data in the elderly population. MATERIAL AND METHOD: A cross-sectional, multicentre study on a consecutive sample of ambulatory bipolar patients (DSM-IV-TR criteria), aged 65 years or over. Retrospective and cross-sectional sociodemographic and clinical data were collected, as well as the Clinical Global Impression for Bipolar Modified scale (CGI-BP-M) and the level of disability using the World Health Organisation Disability Assessment Schedule (WHO/DAS)...
July 2012: Revista de Psiquiatrí́a y Salud Mental
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