Xinhao Duan, Huifang Han, Jing Liu, Yu Qiu, Yi Wang, Xiaotian Wu, Hui Zhang, Zhen Zou, Jingfu Qiu, Chengzhi Chen, Fei Xiao, Xin Tian
Epilepsy constitutes a global health concern, affecting millions of individuals; approximately one-third of patients exhibit drug resistance. Recent investigations have revealed alterations in cerebral iron content in both epilepsy patients and animal models. However, the extant literature lacks a comprehensive exploration into the ramifications of modulating iron homeostasis as an intervention in epilepsy. This study investigated the impact of deferasirox, a nascent iron ion chelator, on epilepsy. This study unequivocally substantiates the antiepileptic efficacy of deferasirox in a kainic acid-induced epilepsy model...
March 30, 2024: Neurochemistry International