Debasis Sahu, Subasa Chandra Bishwal, Md Zubbair Malik, Sukanya Sahu, Sandeep Rai Kaushik, Shikha Sharma, Ekta Saini, Rakesh Arya, Archana Rastogi, Sandeep Sharma, Shanta Sen, R K Brojen Singh, Chuan-Ju Liu, Ranjan Kumar Nanda, Amulya Kumar Panda
Troxerutin (TXR) is a phytochemical reported to possess anti-inflammatory and hepatoprotective effects. In this study, we aimed to exploit the antiarthritic properties of TXR using an adjuvant-induced arthritic (AIA) rat model. AIA-induced rats showed the highest arthritis score at the disease onset and by oral administration of TXR (50, 100, and 200 mg/kg body weight), reduced to basal level in a dose-dependent manner. Isobaric tags for relative and absolute quantitative (iTRAQ) proteomics tool were employed to identify deregulated joint homogenate proteins in AIA and TXR-treated rats to decipher the probable mechanism of TXR action in arthritis...
2022: Frontiers in Cell and Developmental Biology