keyword
MENU ▼
Read by QxMD icon Read
search

troxerutin

keyword
https://www.readbyqxmd.com/read/27807687/troxerutin-preconditioning-and-ischemic-postconditioning-modulate-inflammatory-response-after-myocardial-ischemia-reperfusion-injury-in-rat-model
#1
Reza Badalzadeh, Behzad Baradaran, Alireza Alihemmati, Bahman Yousefi, Azam Abbaszadeh
Protective effects of ischemic postconditioning in myocardial ischemia/reperfusion (I/R) injury have been ever demonstrated, but the exact mechanisms remain unclear. Because of their multiplex activities, using natural pharmaceuticals seems to be clinically interesting. The aim of present study was to investigate the effects of troxerutin preconditioning and ischemic postconditioning on inflammatory responses after myocardial I/R injury in a rat model. Twenty-four Wistar rats were divided into four groups as the control, troxerutin receiving (TXR), postconditioning receiving (PostC), and combined therapy (TXR + PostC)...
November 2, 2016: Inflammation
https://www.readbyqxmd.com/read/27626906/troxerutin-attenuates-diet-induced-oxidative-stress-impairment-of-mitochondrial-biogenesis-and-respiratory-chain-complexes-in-mice-heart
#2
Rajagopalan Geetha, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha
Mitochondrial abnormality is thought to play a key role in cardiac disease originating from the metabolic syndrome (MS). We evaluated the effect of troxerutin (TX), a semi-synthetic derivative of the natural bioflavanoid rutin, on the respiratory chain complex activity, oxidative stress, mitochondrial biogenesis and dynamics in heart of high fat, high fructose diet (HFFD) -induced mouse model of MS. Adult male Mus musculus mice of body weight 25-30 g were fed either control diet or HFFD for 60 days. Mice from each dietary regimen were divided into two groups on the 16(th) day and were treated or untreated with TX (150 mg/Kg bw, p...
September 14, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27589094/troxerutin-imparts-preservative-effects-on-albumin-by-preventing-maillard-reaction-mediated-early-and-advanced-glycation-modification
#3
Saurabh Awasthi, Aravind R, N T Saraswathi
No abstract text is available yet for this article.
September 2, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27488610/the-in-vivo-antineoplastic-and-therapeutic-efficacy-of-troxerutin-on-rat-preneoplastic-liver-biochemical-histological-and-cellular-aspects
#4
Nisha Susan Thomas, Kiran George, Sivaranjani Arivalagan, Vijay Mani, Aktarul Islam Siddique, Nalini Namasivayam
PURPOSE: Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mechanisms of action of TXER against NAFLD/NASH progression to hepatocarcinogenesis. METHODS: The effect of TXER (12.5, 25 or 50 mg/kg b.w/day) was evaluated on the nitrosodiethylamine (NDEA) model of hepatocarcinogenesis in rats, after 16 weeks of oral treatment, with special focus on liver specific enzymes, xenobiotic metabolizing enzymes, antioxidant status, lipid peroxidation profile, DNA damage, fibrosis, cell proliferation and inflammatory status...
August 3, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27481491/protective-effect-of-troxerutin-on-nickel-induced-testicular-toxicity-in-wistar-rats
#5
Perumal Elangovan, Abdulkadhar Mohamed Jalaludeen, Ramalingam Ramakrishnan, Leelavinothan Pari
Nickel (Ni)-induced oxidative damage is a serious problem that leads to reproductive system failure through testicular damage. The present investigation was carried out to determine the effect of troxerutin (Txn) on testicular toxicity induced by Ni in experimental rat testes. The oral administration of Txn (100 mg/kg body weight [bw]) showed a significant (p < 0.01) increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), reduced glutathione, ascorbate, total sulphydryl groups, and testis-organ weight...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27016192/troxerutin-a-natural-flavonoid-binds-to-dna-minor-groove-and-enhances-cancer-cell-killing-in-response-to-radiation
#6
Niranjan A Panat, Beena G Singh, Dharmendra K Maurya, Santosh K Sandur, Saroj S Ghaskadbi
Troxerutin, a flavonoid best known for its radioprotective and antioxidant properties is of considerable interest of study due to its broad pharmacological activities. The present study on troxerutin highlights its abilities to bind DNA and enhance cancer cell killing in response to radiation. Troxerutin showed strong binding with calf thymus DNA in vitro. Troxerutin-DNA interaction was confirmed by CD spectropolarimetry. The mode of binding of troxerutin to DNA was assessed by competing troxerutin with EtBr or DAPI, known DNA intercalator and a minor groove binder, respectively...
May 5, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26601804/involvement-of-ampk-sirt1-pathway-in-anti-allodynic-effect-of-troxerutin-in-cci-induced-neuropathic-pain
#7
Yulong Gui, Aiyuan Li, Feng Chen, Hong Zhou, Yan Tang, Liang Chen, Shuxian Chen, Shunshan Duan
Neuropathic pain was regarded as a main form of chronic pain condition that remains difficult to treat. Conventional pharmacotherapy for neuropathic pain responsed vary and side effects limited their compliance. These prompted us to find new alternatives. In this study, we investigated the effect of troxerutin on treatment of CCI-induced neuropathic pain. Results showed that troxerutin significantly reversed mechanical allodynia and thermal hyperalgesia. In L4-6 spinal cord, troxerutin reduced the expression of INF-γ, IL-1β, TNF-α, and activation of NF-κB(p65)...
December 15, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26477632/interventions-for-varicose-veins-and-leg-oedema-in-pregnancy
#8
REVIEW
Rebecca M D Smyth, Nasreen Aflaifel, Anthony A Bamigboye
BACKGROUND: Pregnancy is presumed to be a major contributory factor in the increased incidence of varicose veins in women, which can in turn lead to venous insufficiency and leg oedema. The most common symptom of varicose veins and oedema is the substantial pain experienced, as well as night cramps, numbness, tingling, the legs may feel heavy, achy, and possibly be unsightly. Treatments for varicose veins are usually divided into three main groups: surgery, pharmacological and non-pharmacological treatments...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26471524/troxerutin-a-plant-flavonoid-protects-cells-against-oxidative-stress-induced-cell-death-through-radical-scavenging-mechanism
#9
Niranjan A Panat, Dharmendra K Maurya, Saroj S Ghaskadbi, Santosh K Sandur
Troxerutin (TRX) is a flavonoid present in tea, coffee, cereal grains, various fruits and vegetables have been reported to exhibit radioprotective, antithrombotic, nephro and hepato-protective effects. A systematic study was undertaken to evaluate its free radical scavenging ability and anti-apoptotic activity in cell-free and cellular systems. TRX scavenged superoxide, nitric oxide and also other model stable radicals like 1,1-diphenyl-2-picryl-hydazyl, and 2,2'-azinobis3-ethylbenzothiazoline-6-sulfonic acid...
March 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26409093/probing-the-interaction-of-troxerutin-with-transfer-rna-by-spectroscopic-and-molecular-modeling
#10
A Subastri, C H Ramamurthy, A Suyavaran, P Lokeswara Rao, E Preedia Babu, K Hari Krishna, M Suresh Kumar, C Thirunavukkarasu
The studies on the interaction between tRNA (transfer RNA) and small molecules are an area of remarkable recent attention. For this notion a fundamental knowledge of the molecular features involving the interaction of small molecules with tRNA is crucial. Hence, in the present study we have investigated the interaction of TXER (troxerutin), natural bioflavonoid rutin derivative with yeast tRNA by using various spectroscopic techniques and molecular docking studies. The UV absorption and fluorescence emission studies demonstrated external binding of TXER on tRNA with low binding constant values as compared to strong binders...
December 2015: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/26341011/phosphorylation-of-gsk-3%C3%AE-and-reduction-of-apoptosis-as-targets-of-troxerutin-effect-on-reperfusion-injury-of-diabetic-myocardium
#11
Behnaz Mokhtari, Reza Badalzadeh, Alireza Alihemmati, Mustafa Mohammadi
Diabetes has various interactions with ischemic heart diseases. Troxerutin, a flavonoid, owns outstanding pharmacological potentials in cardiovascular medicine. The purpose of this study was to investigate the effects of troxerutin on phosphorylation of GSK-3β protein and apoptosis induced by myocardial ischemia-reperfusion injury in healthy and diabetic hearts. Male Wistar rats (n=36, 250-300 g) were randomly divided into four groups: healthy, diabetic, healthy-troxerutin and diabetic-troxerutin. Diabetes was induced by a single injection of streptozotocin (50 mg/kg; ip) and the diabetic period was lasted for ten weeks...
October 15, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26338366/erratum-to-flavonoids-mixture-diosmin-troxerutin-hesperidin-in-the-treatment-of-acute-hemorrhoidal-disease-a-prospective-randomized-triple-blind-controlled-trial
#12
I Giannini, A Amato, L Basso, N Tricomi, M Marranci, G Pecorella, S Tafuri, D Pennisi, D F Altomare
No abstract text is available yet for this article.
October 2015: Techniques in Coloproctology
https://www.readbyqxmd.com/read/26165244/development-and-in-vitro-in-vivo-evaluation-of-a-water-in-oil-microemulsion-formulation-for-the-oral-delivery-of-troxerutin
#13
COMPARATIVE STUDY
Man Xu, Qing Yu, Qianru Zhao, Wei Chen, Yuanjie Lin, Yong Jin
OBJECTIVE: The main objective of this study was to develop and evaluate a W/O microemulsion formulation of troxerutin to improve its oral bioavailability. METHODS: The W/O microemulsion was optimized using a pseudo-ternary phase diagram and evaluated for physical properties. In vitro MDCK cell permeability studies were carried out to evaluate the permeability enhancement effect of microemulsion, and in vivo absorption of troxerutin microemulsion in the intestine was compared with that of solution after single-dose administration (56...
2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/26077659/troxerutin-reverses-fibrotic-changes-in-the-myocardium-of-high-fat-high-fructose-diet-fed-mice
#14
Rajagopalan Geetha, Mutulur Krishnamoorthy Radika, Emayavaramban Priyadarshini, Krishnamurthy Bhavani, Carani Venkatraman Anuradha
A previous study from our laboratory showed that troxerutin (TX) provides cardioprotection by mitigating lipid abnormalities in a high-fat high-fructose diet (HFFD)-fed mice model of metabolic syndrome (MS). The present study aims to investigate the reversal effect of TX on the fibrogenic changes in the myocardium of HFFD-fed mice. Adult male Mus musculus mice were grouped into four and fed either control diet or HFFD for 60 days. Each group was divided into two, and the mice were either treated or untreated with TX (150 mg/kg bw, p...
September 2015: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/26060062/first-epidemiological-data-for-venotonics-in-pregnancy-from-the-efemeris-database
#15
Isabelle Lacroix, Anna-Belle Beau, Caroline Hurault-Delarue, Claire Bouilhac, Dominique Petiot, Christophe Vayssière, Sabine Vidal, Jean-Louis Montastruc, Christine Damase-Michel
OBJECTIVE: There are few published data about possible effects of veinotonics in pregnant women. The present study investigates potential adverse drug reactions of veinotonics in pregnancy. METHOD: EFEMERIS is a database including prescribed and dispensed reimbursed drugs during pregnancy (data from Caisse Primaire d'Assurance Maladie) and outcomes (data from Maternal and Infant Protection Service and Antenatal diagnostic Centre). Women who delivered from 1 July 2004 to December 2007 in Haute-Garonne and were registered in the French Health Insurance Service have been included in the EFEMERIS database...
June 2016: Phlebology
https://www.readbyqxmd.com/read/25955790/analysis-of-changes-in-microrna-expression-profiles-in-response-to-the-troxerutin-mediated-antioxidant-effect-in-human-dermal-papilla-cells
#16
Kyung Mi Lim, Sungkwan An, Ok-Kyu Lee, Myung Joo Lee, Jeong Pyo Lee, Kwang Sik Lee, Ghang Tai Lee, Kun Kook Lee, Seunghee Bae
Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the balding population. In the present study, troxerutin, a flavonoid derivative of rutin, was demonstrated to have a protective effect against H2O2-mediated cellular damage in human DP (HDP) cells. Biochemical assays revealed that pretreatment with troxerutin exerted a protective effect against H2O2-induced loss of cell viability and H2O2-induced cell death...
August 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25926856/beneficial-effect-of-troxerutin-on-diabetes-induced-vascular-damages-in-rat-aorta-histopathological-alterations-and-antioxidation-mechanism
#17
Reza Badalzadeh, Nayeleh Layeghzadeh, Alireza Alihemmati, Mustafa Mohammadi
BACKGROUND: Diabetes is associated with micro- and macro-vascular complications affecting several organs. Oxidative stress plays a crucial role in the etiology of vascular disease in diabetes. OBJECTIVES: The present study aimed to investigate the beneficial effect of troxerutin on diabetes-induced histopathological damages in rat aorta with focusing on its antioxidative actions. MATERIALS AND METHODS: Male Wistar rats were randomly divided into four groups (n = 8/each): control, control plus troxerutin, diabetic and diabetic plus troxerutin...
April 2015: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25893991/flavonoids-mixture-diosmin-troxerutin-hesperidin-in-the-treatment-of-acute-hemorrhoidal-disease-a-prospective-randomized-triple-blind-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
I Giannini, A Amato, L Basso, N Tricomi, M Marranci, G Pecorella, S Tafuri, D Pennisi, D F Altomare
BACKGROUND: The role of a mixture of phlebotonics in the treatment of acute hemorrhoid crisis is investigated to test their efficacy. METHODS: One hundred and thirty-four consecutive patients with an acute hemorrhoidal crisis recruited in five colorectal units entered the study. Sixty-six of them were randomized to receive a mixture of diosmin, troxerutin and hesperidin (group A), and 68 a placebo (group B). The main symptoms, the use of oral painkillers and the Bristol scale score were recorded at each scheduled visit and compared using both Student's t test for independent samples and the ANOVA models for repeated measures...
June 2015: Techniques in Coloproctology
https://www.readbyqxmd.com/read/25858879/spectroscopic-and-molecular-docking-studies-on-the-interaction-of-troxerutin-with-dna
#19
A Subastri, C H Ramamurthy, A Suyavaran, R Mareeswaran, P Lokeswara Rao, M Harikrishna, M Suresh Kumar, V Sujatha, C Thirunavukkarasu
Troxerutin (TXER) is a derivative of naturally occurring bioflavonoid rutin. It possesses different biological activities in rising clinical world. The biological activity possessed by most of the drugs mainly targets on macromolecules. Hence, in the current study we have examined the interaction mechanism of TXER with calf thymus DNA (CT-DNA) by using various spectroscopic methods, isothermal titration calorimetry (ITC) and molecular docking studies. Further, DNA cleavage study was carried out to find the DNA protection activity of TXER...
2015: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/25639565/troxerutin-inhibits-2-2-4-4-tetrabromodiphenyl-ether-bde-47-induced-hepatocyte-apoptosis-by-restoring-proteasome-function
#20
Zi-Feng Zhang, Qun Shan, Juan Zhuang, Yan-Qiu Zhang, Xin Wang, Shao-Hua Fan, Jun Lu, Dong-Mei Wu, Bin Hu, Yuan-Lin Zheng
Proteasome dysfunction has been associated with the pathogeneses of a variety of diseases and with the neurotoxicities of environmental chemicals; however, whether proteasome dysfunction plays a role in the cellular toxicity of polybrominated diphenyl ethers (PBDEs) has not been investigated to date. Emerging evidence suggests that antioxidants exhibit evident beneficial effects on the cellular toxicity associated with PBDEs. In the present study, we investigated whether troxerutin attenuates BDE-47-induced hepatocyte apoptosis by restoring proteasome function and explored the mechanisms underlying this effect...
March 18, 2015: Toxicology Letters
keyword
keyword
120249
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"