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https://www.readbyqxmd.com/read/28717115/coronary-artery-disease-and-type-2-diabetes-mellitus
#1
Ryo Naito, Katsumi Miyauchi
Type 2 diabetes mellitus (T2DM) is a major risk factor of coronary artery diseases (CAD). Clinical outcomes in CAD with T2DM are poor despite improvement in medications and intervention devices. Coronary artery bypass grafting (CABG) is superior to percutaneous coronary intervention (PCI) in treating diabetic patients with multivessel coronary artery diseases (MVD). However, selecting a revascularization strategy should depend not only on the lesion complexity but also on the patient's background and comorbidities...
July 14, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28709449/a-novel-alzheimer-s-disease-drug-candidate-targeting-inflammation-and-fatty-acid-metabolism
#2
Daniel Daugherty, Joshua Goldberg, Wolfgang Fischer, Richard Dargusch, Pamela Maher, David Schubert
BACKGROUND: CAD-31 is an Alzheimer's disease (AD) drug candidate that was selected on the basis of its ability to stimulate the replication of human embryonic stem cell-derived neural precursor cells as well as in APPswe/PS1ΔE9 AD mice. To move CAD-31 toward the clinic, experiments were undertaken to determine its neuroprotective and pharmacological properties, as well as to assay its therapeutic efficacy in a rigorous mouse model of AD. RESULTS: CAD-31 has potent neuroprotective properties in six distinct nerve cell assays that mimic toxicities observed in the old brain...
July 14, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28707234/the-elusive-search-for-optimal-blood-pressure-targets
#3
REVIEW
Alan H Gradman
BP treatment thresholds/targets determine when to initiate treatment and to what level BP should be reduced. The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) recommended a target of <140/90 for most patients and a target <130/80 mmHg for patients with diabetes or chronic kidney disease. Subsequently, meta-analyses, retrospective studies relating on-treatment BP to clinical outcomes and two large, randomized clinical trials (RCTs) have re-evaluated BP targets...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28705312/community-based-lifestyle-intervention-in-patients-with-coronary-artery-disease-the-response-2-trial
#4
Madelon Minneboo, Sangeeta Lachman, Marjolein Snaterse, Harald T Jørstad, Gerben Ter Riet, S Matthijs Boekholdt, Wilma J M Scholte Op Reimer, Ron J G Peters
BACKGROUND: Among patients with coronary artery disease (CAD), improvement of lifestyle-related risk factors (LRFs) reduces cardiovascular morbidity and mortality. However, modification of LRFs is highly challenging. OBJECTIVES: This study sought to evaluate the impact of combining community-based lifestyle programs with regular hospital-based secondary prevention. METHODS: The authors performed a randomized controlled trial of nurse-coordinated referral of patients and their partners to 3 widely available community-based lifestyle programs, in 15 hospitals in the Netherlands...
July 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28693891/an-alarming-trend-change-in-the-risk-profile-of-patients-with-st-elevation-myocardial-infarction-over-the-last-two-decades
#5
Amgad Mentias, Elizabeth Hill, Amr F Barakat, Mohammad Q Raza, Dalia Youssef, Kinjal Banerjee, Abhishek C Sawant, Stephen Ellis, E Murat Tuzcu, Samir R Kapadia
BACKGROUND: Coronary artery disease (CAD) is the leading cause of mortality around the world. We sought to study changes in the risk profile of patients presenting with ST elevation myocardial infarction (STEMI). METHODS: We retrospectively studied all patients presenting with STEMI to our center between 1995 and 2014. Patients were divided into four quartiles, 5years each. Baseline risk factors and comorbidities were recorded. Sub-analysis was done for patients with established CAD and their household incomes...
July 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28692742/vitamin-k-antagonists-with-or-without-long-term-antiplatelet-therapy-in-outpatients-with-stable-coronary-artery-disease-and-atrial-fibrillation-association-with-ischemic-and-bleeding-events
#6
Gilles Lemesle, Gregory Ducrocq, Yedid Elbez, Eric Van Belle, Shinya Goto, Christopher P Cannon, Christophe Bauters, Deepak L Bhatt, Philippe Gabriel Steg
BACKGROUND: It remains uncertain whether patients with atrial fibrillation (AF) requiring long-term oral anticoagulation (OAC) and with stable coronary artery disease (CAD) should receive antiplatelet therapy (APT) in addition to OAC. HYPOTHESIS: APT in addition to OAC would be more effective than OAC alone in preventing ischaemic events in such patients. METHODS: In the international REduction of Atherothrombosis for Continued Health (REACH) Registry including 68 236 outpatients with or at risk for atherothrombosis, we identified 2347 patients with stable CAD and AF receiving vitamin K antagonists (VKA)...
July 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28687538/temporal-trends-of-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-in-patients-with-coronary-artery-disease-a-22-year-experience-from-a-tertiary-academic-medical-center
#7
Hayan Jouni, J Wells Askew, Daniel J Crusan, Todd D Miller, Raymond J Gibbons
BACKGROUND: There has been a gradual decline in the prevalence of abnormal stress single-photon emission computed tomography (SPECT) myocardial perfusion imaging studies among patients without history of coronary artery disease (CAD). The trends of SPECT studies among patients with known CAD have not been evaluated previously. METHODS AND RESULTS: We assessed the Mayo Clinic nuclear cardiology database for all stress SPECT tests performed between January 1991 and December 2012 in patients with history of CAD defined as having previous myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting...
July 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28675748/a-preliminary-study-for-the-assessment-of-hypertension-using-static-and-dynamic-ir-thermograms
#8
Jayanthi Thiruvengadam, Anburajan Mariamichael
Structural changes in blood vessels occur due to prolonged hypertension. Early detection of blood pressure (mm Hg) is essential for disease prevention. The aim of this work is to propose a computer-aided diagnostic (CADx) model for the diagnosis of hypertension using variables derived from non-contact static and dynamic thermal imaging in comparison with the pulse wave velocity (PWV)-derived parameters. Static and dynamic infrared (IR) thermograms of selected skin areas of the body from known hypertensive (n=14) and age- and sex-matched normal subjects were captured...
July 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28652671/aortic-velocity-propagation-a-novel-echocardiographic-method-in-predicting-atherosclerotic-coronary-artery-disease-burden
#9
Pakala Vasudeva Chetty, Durgaprasad Rajasekhar, Velam Vanajakshamma, Kummaraganti P Ranganayakulu, Dommara Kranthi Chaithanya
BACKGROUND: The major burden of cardiovascular disease mortality around the globe is due to atherosclerosis and its complications. Hence its early detection and management with easily accessible and noninvasive methods are valuable. Aortic velocity propagation (AVP) through color M-mode of the proximal descending aorta determines aortic stiffness, reflecting atherosclerosis. The aim of this study was to find the utility of AVP in predicting coronary artery disease (CAD) burden assessed through SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score and compared with carotid intima-media thickness (CIMT), which is an established surrogate marker of atherosclerosis...
July 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28646123/expression-of-mir-23a-induces-telomere-shorteningand-is-associated-with-poor-clinical-outcomesin-patients-with-coronary-artery-disease
#10
Mamoru Satoh, Takahito Nasu, Yuji Takahashi, Takuya Osaki, Sho Hitomi, Yoshihiro Morino, Motoyuki Nakamura
Telomeric repeat binding factor 2 (TRF2) plays an important role in telomere maintenance. MicroRNA (miR)-23a may directly inhibit TRF2 expression, inducing telomere shortening and cellular senescence. This study aimed to determine whether miR-23a and TRF2 are expressed in patients with coronary artery disease (CAD), and whether pitavastatin might affect these levels. This study included 104 patients with CAD and 50 controls. Patients with CAD were randomly divided into two subgroups [a moderate lipid lowering therapy (LLT) group and an aggressive LLT group]...
June 23, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28636510/the-balance-of-omega-3-polyunsaturated-fatty-acids-for-reducing-residual-risks-in-patients-with-coronary-artery-disease
#11
Yuji Nishizaki, Kazunori Shimada, Hiroyuki Daida
Residual risk, which cannot be prevented by statins alone, must be controlled for inhibiting the onset of coronary events. Omega-3 polyunsaturated fatty acids (PUFAs) play an important role in controlling residual risk. The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study demonstrated the inhibitory effect of high-purity EPA preparations on the residual risk of cardiovascular events. Omega-3 PUFAs inhibit coronary artery disease (CAD) through various actions, including triglyceride-lowering action...
March 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28629303/dual-antiplatelet-therapy-beyond-one-year-in-patients-after-stent-placement-a-review
#12
Jacob D Sumner, Brianna Zinser, Andrew Smith
PURPOSE: To review the evidence on the safety and efficacy of the continued use of dual antiplatelet therapy (DAPT) beyond 12 months after stent placement in patients following an acute coronary syndrome (ACS) event. SUMMARY: Recently, the American College of Cardiology (ACC) and the American Heart Association (AHA) released a focused update on the duration of DAPT in patients with coronary artery disease (CAD). The update makes new recommendations about the duration of DAPT in light of recently performed studies investigating this topic...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28611783/apolipoprotein-l1-genetic-variants-are-associated-with-chronic-kidney-disease-but-not-with-cardiovascular-disease-in-a-population-referred-for-cardiac-catheterization
#13
Hanghang Wang, Patrick H Pun, Lydia Kwee, Damian Craig, Carol Haynes, Megan Chryst-Ladd, Laura P Svetkey, Uptal D Patel, Elizabeth R Hauser, Martin R Pollak, William E Kraus, Svati H Shah
BACKGROUND: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by APOL1 variants in a secondary cardiovascular prevention population. METHODS: Two risk variants in APOL1 were genotyped in African-Americans (n = 1,641) enrolled in the CATHGEN biorepository, comprised of patients referred for cardiac catheterization at Duke University Hospital, Durham, NC, USA (2001-2010)...
February 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28593492/classical-determinants-of-coronary-artery-disease-as-predictors-of-complexity-of-coronary-lesions-assessed-with-the-syntax-score
#14
J M Montero-Cabezas, I Karalis, R Wolterbeek, A O Kraaijeveld, I E Hoefer, G Pasterkamp, N H Pijls, P A Doevendans, J Walterberger, J Kuiper, A J van Zonneveld, J W Jukema
BACKGROUND: We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships with these potential biomarkers. We sought to analyse the correlation of the SYNTAX score with known CAD risk factors to test it as a valid marker of CAD extension...
June 7, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28590311/aspirin-challenge-and-desensitization-how-when-and-why
#15
Gabriele Cortellini, Cristiano Caruso, Antonino Romano
PURPOSE OF REVIEW: To investigate the current approach to aspirin challenge (drug provocation) and/or desensitization in patients with histories of hypersensitivity reactions to it, particularly in those with cardiovascular diseases. RECENT FINDINGS: The literature indicates that patients with coronary artery disease (CAD), including those with an acute coronary syndrome, may safely undergo low-dose aspirin challenge and/or desensitization. Recently, flowcharts regarding challenge/desensitization procedures with aspirin in patients with CAD and histories of aspirin hypersensitivity reactions have become available...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28584231/identification-of-15-novel-risk-loci-for-coronary-artery-disease-and-genetic-risk-of-recurrent-events-atrial-fibrillation-and-heart-failure
#16
Niek Verweij, Ruben N Eppinga, Yanick Hagemeijer, Pim van der Harst
Coronary artery disease (CAD) is the major cause of morbidity and mortality in the world. Identification of novel genetic determinants may provide new opportunities for developing innovative strategies to predict, prevent and treat CAD. Therefore, we meta-analyzed independent genetic variants passing P <× 10(-5) in CARDIoGRAMplusC4D with novel data made available by UK Biobank. Of the 161 genetic variants studied, 71 reached genome wide significance (p < 5 × 10(-8)) including 15 novel loci. These novel loci include multiple genes that are involved in angiogenesis (TGFB1, ITGB5, CDH13 and RHOA) and 2 independent variants in the TGFB1 locus...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28574750/calcium-dobesilate-prevents-neurodegeneration-and-vascular-leakage-in-experimental-diabetes
#17
Cristina Solà-Adell, Patricia Bogdanov, Cristina Hernández, Joel Sampedro, Marta Valeri, Marta Garcia-Ramirez, Christian Pasquali, Rafael Simó
PURPOSE: The mechanisms involved in the reported beneficial effects of Calcium dobesilate monohydrate (CaD) for the treatment of diabetic retinopathy (DR) remain to be elucidated. The main aim of the present study is to examine whether CaD prevents early events in the pathogenesis of DR such as neurodegeneration and vascular leakage. In addition, putative mediators of both neurodegeneration (glutamate/GLAST, ET-1/ETB receptor) and early microvascular impairment (ET-1/ETA receptor, oxidative stress, VEGF, and the PKC-delta-p38 MAPK pathway) have been examined...
June 2, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28565969/effectiveness-of-endurance-exercise-training-in-patients-with-coronary-artery-disease-a-meta-analysis-of-randomised-controlled-trials
#18
Yu-Chi Chen, Jen-Chen Tsai, Yiing-Mei Liou, Paul Chan
BACKGROUND: Exercise interventions apparently reduce the risks of and prevent coronary artery disease (CAD). Developing an exercise intervention for patients with CAD is a rapidly expanding focus worldwide. The results of previous studies are inconsistent and difficult to interpret across various types of exercise programme. AIM: This study aimed to update prior systemic reviews and meta-analyses in order to determine the overall effects of endurance exercise training on patients with CAD...
June 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28561986/rationale-design-and-baseline-characteristics-of-the-clarify-registry-of-outpatients-with-stable-coronary-artery-disease
#19
Emmanuel Sorbets, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim M Fox, Jean-Claude Tardif, Michal Tendera, Philippe Gabriel Steg
BACKGROUND: Despite major advances in prevention and treatment, coronary artery disease (CAD) remains the leading cause of death worldwide. Whereas many sources of data are available on the epidemiology of acute coronary syndromes, fewer datasets reflect the contemporary management and outcomes of stable CAD patients. HYPOTHESIS: A worldwide contemporary registry would improve our knowledge about stable CAD. The main objectives are to describe the demographics, clinical profile, contemporary management and outcomes of outpatients with stable CAD; to identify gaps between evidence and treatment; and to investigate long-term prognostic determinants...
May 31, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28559653/clinical-characteristics-of-patients-less-than-forty-years-old-with-coronary-artery-disease-in-taiwan-a-cross-sectional-study
#20
Wei-Che Tsai, Keng-Yi Wu, Gen-Min Lin, Sy-Jou Chen, Wei-Shiang Lin, Shih-Ping Yang, Shu-Meng Cheng, Chin-Sheng Lin
BACKGROUND: Coronary artery disease (CAD) rarely occurs in young adults. Our objective was to investigate the baseline characteristics and outcomes of young patients with CAD. METHODS: We retrospectively enrolled patients aged < 40 years of age who underwent coronary angiography in a tertiary hospital in Taiwan between 2002 and 2015. The baseline characteristics and in-hospital outcomes of patients with acute coronary syndrome (ACS) and occlusive CAD (stenotic lesions > 50%) were compared with those of patients without ACS and non-occlusive CAD, respectively...
May 2017: Acta Cardiologica Sinica
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