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https://www.readbyqxmd.com/read/28215731/complementopathies
#1
REVIEW
Andrea C Baines, Robert A Brodsky
The complement system is an essential part of the innate immune system that requires careful regulation to ensure responses are appropriately directed against harmful pathogens, while preventing collateral damage to normal host cells and tissues. While deficiency in some components of the complement pathway is associated with increased susceptibility to certain infections, it has also become clear that inappropriate activation of complement is an important contributor to human disease. A number of hematologic disorders are driven by complement, and these disorders may be termed "complementopathies"...
February 6, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28207434/leveraging-information-from-genetic-risk-scores-of-coronary-atherosclerosis
#2
Themistocles L Assimes, Elias L Salfati, Liana C Del Gobbo
PURPOSE OF REVIEW: Genome-wide association studies (GWAS) have identified ∼60 loci for coronary artery disease (CAD). Through genetic risk scores (GRSs), investigators are leveraging this genomic information to gain insights on both the fundamental mechanisms driving these associations as well as their utility in improving risk prediction. RECENT FINDINGS: GRSs of CAD track with the earliest atherosclerosis lesions in the coronary including fatty streaks and uncomplicated raised lesions...
February 14, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28202258/sudden-cardiac-death-and-coronary-disease-in-the-young-a-nationwide-cohort-study-in-denmark
#3
Sára Zachariasardóttir, Bjarke Risgaard, Frederik Nybye Ågesen, Reza Jabbari, Charlotte Glinge, Ole Ingemann-Hansen, Gyda Lolk Ottesen, Jørgen Lange Thomsen, Stig Haunsø, Jytte Banner, Bo Gregers Winkel, Jacob Tfelt-Hansen
BACKGROUND: Sudden cardiac death caused by coronary artery disease (CAD-SCD) is the most frequent cause of SCD in persons <50years. The aim of this study was to examine differences in clinical characteristics and autopsy findings of the heart among 18-35 and 36-49year old CAD-SCD cases. METHODS: We have previously identified all sudden cardiac deaths in Denmark through review of death certificates and autopsy reports including all deaths between 2000 and 2006 in individuals aged 18-35years and all deaths between 2007 and 2009 in individuals aged 18-49years...
January 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28195693/assembly-domain-based-optogenetic-system-for-the-efficient-control-of-cellular-signaling
#4
Akihiro Furuya, Fuun Kawano, Takahiro Nakajima, Yoshibumi Ueda, Moritoshi Sato
We previously developed the Magnet system, which consists of two distinct Vivid protein variants, one positively and one negatively charged, designated the positive Magnet (pMag) and negative Magnet (nMag), respectively. These two proteins bind to each other through electrostatic interactions, preventing unwanted homodimerization and providing selective light-induced heterodimerization. The Magnet system enables the manipulation of cellular functions such as protein-protein interactions and genome editing, although the system could be improved further...
February 14, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28184335/drug-and-gene-eluting-stents-for-preventing-coronary-restenosis
#5
REVIEW
Kamali Manickavasagam Lekshmi, Hui-Lian Che, Chong-Su Cho, In-Kyu Park
Coronary artery disease (CAD) has been reported to be a major cause of death worldwide. Current treatment methods include atherectomy, coronary angioplasty (as a percutaneous coronary intervention), and coronary artery bypass. Among them, the insertion of stents into the coronary artery is one of the commonly used methods for CAD, although the formation of in-stent restenosis (ISR) is a major drawback, demanding improvement in stent technology. Stents can be improved using the delivery of DNA, siRNA, and miRNA rather than anti-inflammatory/anti-thrombotic drugs...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28181534/genomic-variant-in-il-37-confers-a-significant-risk-of-coronary-artery-disease
#6
Dan Yin, Duraid Hamied Naji, Yunlong Xia, Sisi Li, Ying Bai, Guiqing Jiang, Yuanyuan Zhao, Xiaojing Wang, Yufeng Huang, Shanshan Chen, Jingjing Fa, Chengcheng Tan, Mengchen Zhou, Yingchao Zhou, Longfei Wang, Ying Liu, Feifei Chen, Jingqiu Liu, Qiuyun Chen, Xin Tu, Chengqi Xu, Qing K Wang
The interleukin 1 family plays an important role in the immune and inflammatory responses. Coronary artery disease (CAD) is a chronic inflammatory disease. However, the genetic association between IL-37, the seventh member of the IL-1 family, and CAD is unknown. Here we show that a single nucleotide polymorphism in the IL-37 gene (rs3811047) confers a significant risk of CAD. We have performed an association analysis between rs3811047 and CAD in two independent populations with 2,501 patients and 3,116 controls from China...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28176521/implantable-cardioverter-defibrillators-for-primary-prevention-in-patients-with-nonischemic-cardiomyopathy-a-systematic-review-and-meta-analysis
#7
Tamer Akel, James Lafferty
INTRODUCTION: Implantable cardioverter defibrillators (ICDs) have proved their benefit in exerting favorable outcomes on survival in selected patients with cardiomyopathy. Although previous meta-analyses have shown benefit for their use in primary prevention, the evidence is less robust for patients with NICM in comparison to patients with CAD. In this meta-analysis we evaluated the ability of ICD therapy in reducing all-cause mortality and sudden cardiac Death (SCD) in patients with NICM...
February 8, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28164120/coronary-computed-tomography-angiography-in-combination-with-coronary-artery-calcium-scoring-for-the-preoperative-cardiac-evaluation-of-liver-transplant-recipients
#8
REVIEW
Jae Moon Choi, Yu-Gyeong Kong, Joon-Won Kang, Young-Kug Kim
Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical techniques and perioperative care have improved postoperative outcomes, perioperative cardiovascular complications are a leading cause of postoperative morbidity and mortality following liver transplantation. Ischemic coronary artery disease (CAD) and cardiomyopathy are the most common cardiovascular diseases and could be negative predictors of postoperative outcomes in liver transplant recipients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28160245/lipoprotein-a-hyperlipoproteinemia-as-cause-of-chronic-spinal-cord-ischemia-resulting-in-progressive-myelopathy-successful-treatment-with-lipoprotein-apheresis
#9
Franz Heigl, Reinhard Hettich, Erich Mauch, Reinhard Klingel, Cordula Fassbender
High concentrations of lipoprotein(a) (Lp(a)) represent an important independent and causal risk factor associated with adverse outcome in atherosclerotic cardiovascular disease (CVD). Effective Lp(a) lowering drug treatment is not available. Lipoprotein apheresis (LA) has been proven to prevent cardiovascular events in patients with Lp(a)-hyperlipoproteinemia (Lp(a)-HLP) and progressive CVD. Here we present the course of a male patient with established peripheral arterial occlusive disease (PAOD) at the early age of 41 and coronary artery disease (CAD), who during follow-up developed over 2 years a progressive syndrome of cerebellar and spinal cord deficits against the background of multifactorial cardiovascular risk including positive family history of CVD...
February 3, 2017: Clinical Research in Cardiology Supplements
https://www.readbyqxmd.com/read/28153261/determination-of-aliphatic-amines-in-food-by-on-fiber-derivatization-solid-phase-microextraction-with-a-novel-zeolitic-imidazolate-framework-8-coated-stainless-steel-fiber
#10
Jie Huang, Changrong Ou, Fangying Lv, Yuting Cao, Haiqing Tang, You Zhou, Ning Gan
Some harmful aliphatic diamines, e.g., putrescine (Put) and cadaverine (Cad), play important roles in food safety evaluation. In this study, we proposed on-fiber derivatization solid-phase microextraction analysis of non-volatile aliphatic diamines in fish using zeolitic imidazolate framework 8 (ZIF-8) as a solid-phase microextraction (SPME) coating. It was employed to encapsulate isobutyl chloroformate (IBCF, 40°C, 15min) for aqueous extraction of Put and Cad. After that, the derivatized aliphatic amines were thermally desorbed in the GC injection port and analyzed by GC-MS...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28143388/effects-of-cardiac-telerehabilitation-in-patients-with-coronary-artery-disease-using-a-personalised-patient-centred-web-application-protocol-for-the-smartcare-cad-randomised-controlled-trial
#11
Rutger W M Brouwers, Jos J Kraal, Simone C J Traa, Ruud F Spee, Laurence M L C Oostveen, Hareld M C Kemps
BACKGROUND: Cardiac rehabilitation has beneficial effects on morbidity and mortality in patients with coronary artery disease, but is vastly underutilised and short-term improvements are often not sustained. Telerehabilitation has the potential to overcome these barriers, but its superiority has not been convincingly demonstrated yet. This may be due to insufficient focus on behavioural change and development of patients' self-management skills. Moreover, potentially beneficial communication methods, such as internet and video consultation, are rarely used...
January 31, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28139223/urinary-11-dehydro-thromboxane-b2-and-mortality-in-patients-with-stable-coronary-artery-disease
#12
Peter A McCullough, Anupama Vasudevan, Mohanakrishnan Sathyamoorthy, Jeffrey M Schussler, Carlos E Velasco, Luis R Lopez, Caren Swift, Margarita Peterson, Jenna Bennett-Firmin, Raphael Schiffmann, Teodoro Bottiglieri
Antiplatelet therapy with aspirin has been shown to reduce adverse outcomes in patients with coronary artery disease (CAD). Aspirin irreversibly inhibits platelet cyclooxygenase-1 and attenuates thromboxane A2 (TXA2)-mediated platelet aggregation, but there is variable suppression of cyclooxygenase-1. From a cohort of patients with stable CAD, we performed blinded, detailed chart abstraction, and measured urinary 11-dehydro-thromboxane B2 (11dhTxB2), an inactive metabolite of TxA2 from frozen samples. There were 327 men (73%) and 122 women (27%) with a mean age (±SD) of 67 ± 10 and 65 ± 10 years, respectively...
January 5, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28129469/implantable-cardioverter-defibrillators-for-primary-prevention-in-patients-with-nonischemic-cardiomyopathy-a-systematic-review-and-meta-analysis
#13
Tamer Akel, James Lafferty
BACKGROUND: Implantable cardioverter defibrillators (ICDs) have proved their benefit in exerting favorable outcomes on survival in selected patients with cardiomyopathy. Although previous meta-analyses have shown benefit for their use in primary prevention, the evidence is less robust for patients with NICM in comparison to patients with CAD. OBJECTIVES: To evaluate the ability of ICD therapy in reducing all-cause mortality and sudden cardiac death (SCD) in patients with NICM...
January 27, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28128747/use-of-thrombin-generation-test-for-monitoring-hemostasis-in-coronary-bypass-surgery
#14
Gruzdeva Olga, Uchasova Evgenya, Fanaskova Elena, Akbasheva Olga, Penskaya Tatyana, Plotnikov Georgy, Dyleva Yulia, Barbarash Olga
To evaluate the parameters of the thrombin generation test (TGT) in coronary artery disease (CAD) patients on prolonged aspirin therapy during on-pump coronary artery bypass grafting (CABG) after donor platelet concentrate transfusion. A total of 148 patients with CAD on prolonged aspirin therapy (75-100 mg/day) who have undergone elective on-pump CABG were consecutively included in the study. Patients were divided randomly into two groups. Group 1 (n = 76) received donor platelet transfusions after cardiopulmonary bypass, whereas Group 2 (n = 72) did not...
January 27, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28117280/post-procedural-myocardial-infarction-following-surgical-and-trans-catheter-aortic-valve-replacement
#15
Laura E Dobson, Tarique A Musa, Akhlaque Uddin, Timothy A Fairbairn, Peter P Swoboda, David P Ripley, Pankaj Garg, Betsy Evans, Christopher J Malkin, Daniel J Blackman, Sven Plein, John P Greenwood
AIMS: Myocardial injury assessed using cardiac biomarker release is ubiquitous following surgical (SAVR) and trans-catheter aortic valve implantation (TAVI), preventing accurate discrimination between focal myocardial infarction (MI) and global injury. Cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) imaging was used to compare rates of new MI following SAVR and TAVI. METHODS AND RESULTS: Identical CMR scans were obtained at baseline and 6m post- procedure in ninety-six patients undergoing SAVR (n=39) and TAVI (n=57)...
January 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28106491/effect-of-an-mg132-sustained-drug-delivery-capsular-ring-on-the-inhibition-of-posterior-capsule-opacification-in-a-rabbit-model
#16
Xuan Bao, Min Hou, Yingyan Qin, Furong Luo, Fu Shang, Mingxing Wu
PURPOSE: To design an MG132-sustained drug delivery capsular ring (SDDCR) and investigate its effect on the inhibition of posterior capsule opacification (PCO) in a rabbit model. METHODS: The SDDCRs were prepared by forming a slice of film made by the mixture of poly lactic-co-glycolic acid (PLGA) and MG132 on the surface of capsular tension rings (CTRs). The drug-loading capacity, entrapment efficiency, and in vitro release of the drug-containing film were detected...
January 20, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28104968/effects-of-rosuvastatin-alone-or-in-combination-with-omega-3-fatty-acid-on-adiponectin-levels-and-cardiometabolic-profile
#17
Hayder M Al-Kuraishy, Ali I Al-Gareeb
BACKGROUND: Adiponectin is an important adipocyte-related protein that has been postulated to participate in prevention of the development of metabolic syndrome. The relationship between adiponectin serum levels and risk of coronary artery disease (CAD) has been widely investigated and remains controversial. The aim of the present study was to evaluate the effects of rosuvastatin and/or omega-3 fatty acid on adiponectin serum levels in patients with insulin resistance (IR) and CAD. PATIENTS AND METHODS: This study involved 87 patients with CADs and IR of different etiology, the patients were divided into three groups; 24 patients on treatment with rosuvastatin, 22 patients on treatment with omega-3 fatty acid, 23 patients on treatment with omega-3 fatty acid and rosuvastatin, 18 patients were not previously or currently treated with either rosuvastatin or omega-3 fatty acid, those regarded as control patients...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28103397/the-economic-burden-of-nurse-sensitive-adverse-events-in-22-medical-surgical-units-retrospective-and-matching-analysis
#18
Eric Tchouaket, Carl-Ardy Dubois, Danielle D'Amour
AIMS: To assess the economic burden of nurse-sensitive adverse events (NSAEs) in 22 acute care units in Quebec by estimating excess hospital-related costs and calculating resulting additional hospital days. BACKGROUND: Recent changes in the worldwide economic and financial contexts have made the cost of patient safety a topical issue. Yet our knowledge about the economic burden of safety of nursing care is quite limited in Canada in general and Quebec in particular...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28102898/a-composite-autonomic-index-as-unitary-metric-for-heart-rate-variability-a-proof-of-concept
#19
Roberto Sala, Mara Malacarne, Nadia Solaro, Massimo Pagani, Daniela Lucini
BACKGROUND: This study addresses whether a unitary cardiac autonomic nervous system index (ANSI), obtained combining multiple metrics from Heart Rate Variability (HRV) into a radar plot could provide an easy appreciation of autonomic performance in a clinical setting. MATERIALS AND METHODS: Data are standardized using percentile ranking of autonomic proxies from a relatively large reference population (n= 1593, age 39±13 years). Autonomic indices are obtained from autoregressive spectral analysis of (ECG derived) HRV at rest and during standing up...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28099219/a-review-of-the-clinical-utility-of-intravascular-ultrasound-ivus-and-optical-coherence-tomography-oct-in-the-assessment-and-treatment-of-coronary-artery-disease
#20
Stephen Daniel Matthews, William H Frishman
Coronary artery disease (CAD) remains one of the leading causes of morbidity and mortality in the United States. As a medical society, we continue to search for ways to better treat CAD and prevent acute coronary syndrome (ACS). As it stands, only statins and anti-platelets agents have been proven to significantly reduce the occurrence of ACS. A histopathological understanding of the pathogenesis of ACS has provided insight into the importance of plaque morphology. Therefore, it has been proposed that increasing the ability to detect true vulnerable, "at-risk" lesions, would foster the use of percutaneous coronary intervention as a means for the prevention of ACS...
January 11, 2017: Cardiology in Review
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