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https://www.readbyqxmd.com/read/29923323/sex-differences-in-management-and-outcomes-of-patients-with-type-2-diabetes-and-cardiovascular-disease-a-report-from-tecos
#1
Joakim Alfredsson, Jennifer B Green, Susanna R Stevens, Shelby D Reed, Paul W Armstrong, M Angelyn Bethel, Samuel S Engel, Darren K McGuire, Frans Van de Werf, Irene Hramiak, Harvey D White, Eric D Peterson, Rury R Holman
AIM: To examine sex differences in baseline characteristics and outcomes in patients with type 2 diabetes and atherosclerotic vascular disease. MATERIALS AND METHODS: Cox models were used to analyse the association between sex and outcomes in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), a randomized, placebo-controlled trial assessing the impact of sitagliptin on cardiovascular (CV) outcomes in patients with type 2 diabetes and atherosclerotic vascular disease...
June 19, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29922878/aspirin-inspired-acetyl-donating-hdacs-inhibitors
#2
Jiah Lim, Yoojin Song, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee, Byoungduck Park, Young Ho Seo
Aspirin is one of the oldest drugs for the treatment of inflammation, fever, and pain. It is reported to covalently modify COX-2 enzyme by acetylating a serine amino acid residue. By virtue of aspirin's acetylating potential, we for the first time developed novel acetyl-donating HDAC inhibitors. In this study, we report the design, synthesis, in silico docking study, and biological evaluation of acetyl-donating HDAC inhibitors. The exposure of MDA-MB-231 cells with compound 4c significantly promotes the acetylation of α-tubulin and histone H3, which are substrates of HDAC6 and HDAC1, respectively...
June 20, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29913174/low-dose-aspirin-is-associated-with-reduced-spontaneous-preterm-birth-in-nulliparous-women
#3
Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman
BACKGROUND: Preterm birth (PTB) is one of the leading causes of perinatal morbidity and mortality. Clinical data suggests that low dose aspirin may decrease the rate of overall PTB, but investigators have speculated that this is likely due to a decrease in medically indicated PTB through its effect on the incidence of preeclampsia and other placental disease. We hypothesized that low dose aspirin may also impact the mechanism of spontaneous preterm labor. OBJECTIVE: Our objective was to determine whether low dose aspirin reduces the rate of spontaneous PTB in nulliparous women without medical co-morbidities...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29898848/oral-anti-xa-anticoagulation-after-trans-aortic-valve-implantation-for-aortic-stenosis-the-randomized-atlantis-trial
#4
Jean-Philippe Collet, Sergio Berti, Angel Cequier, Eric Van Belle, Thierry Lefevre, Pascal Leprince, Franz-Josef Neumann, Eric Vicaut, Gilles Montalescot
BACKGROUND: Antithrombotic treatment regimen following transcatheter aortic valve replacement (TAVR) is not evidence-based. Apixaban, a non-vitamin K direct anticoagulant (NOAC) was shown to be superior to VKA and superior to aspirin to prevent cardioembolic stroke in non-valvular atrial fibrillation. It may have the potential to reduce TAVR-related thrombotic complications including subclinical valve thrombosis along with a better safety than the standard of care. DESIGN: ATLANTIS is a multicenter, randomized, phase IIIb, prospective, open-label, superiority study comparing standard of care (SOC Group) versus an apixaban-based strategy (Anti-Xa Group) after successful TAVR (ClinicalTrials...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29885857/from-epidemiology-to-treatment-aspirin-s-prevention-of-brain-and-breast-cancer-and-cardioprotection-may-associate-with-its-metabolite-gentisic-acid
#5
Meric A Altinoz, Ilhan Elmaci, Salih Cengiz, Ebru Emekli-Alturfan, Aysel Ozpinar
BACKGROUND: Epidemiological studies indicate that aspirin consumption reduces the risk of tumors, which is especially relevant for colonic adenoma and carcinoma. Similar observations were made for glial brain tumors and breast cancers, yet the results are inconsistent. Gentisic acid (GA) is a minor catabolite of aspirin; yet humans carrying CYP2C9-variants incapable to catabolize aspirin to GA do not benefit from aspirin in prevention against colonic adenoma. GA blocks binding of Fibroblastic Growth Factor to its receptor and its sulphonate metabolite dobesilic acid blocks growth of C6 glioblastoma in vivo...
June 7, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29883785/indole-alkaloids-and-anti-nociceptive-mechanisms-of-tabernaemontana-divaricata-l-r-br-flower-methanolic-extract
#6
Mohammed Safwan Ali Khan, Misbah, Nishat Ahmed, Mohammed Arifuddin, Abdullah Rehman, Mok Pooi Ling
Flowers of Tabernaemontana divaricata (L.) R. Br., (Apocynaceae) are used in traditional medicine for analgesic property. The present study was performed to isolate the active principles and investigate the mechanisms involved in the anti-nociception caused by T. divaricata flower methanolic extract (TDFME). The extract in the doses of 125, 250 and 500 mg/kg, p.o was subjected to various assays in acetic acid induced abdominal writhing and formalin induced paw licking test models. Naloxone, L-Arginine, Glibenclamide and Glutamate were used as inducers while Morphine, L-NAME, Methylene blue and Aspirin served as standard drugs...
June 5, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29870868/design-of-healthy-hearts-in-the-heartland-h3-a-practice-randomized-comparative-effectiveness-study
#7
Jody D Ciolino, Kathryn L Jackson, David T Liss, Tiffany Brown, Theresa L Walunas, Linda Murakami, Isabel Chung, Stephen D Persell, Abel N Kho
BACKGROUND: The Healthy Hearts in the Heartland (H3) study is part of a nationwide effort, EvidenceNOW, seeking to better understand the ability of small primary care practices to improve "ABCS" clinical quality measures: appropriate Aspirin therapy, Blood pressure control, Cholesterol management, and Smoking cessation. H3 aimed to assess feasibility of implementing Point-of-Care (POC) or POC plus Population Management (POC + PM) quality improvement (QI) strategies to improve ABCS at practices in Illinois, Indiana, and Wisconsin...
June 2, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29869923/individual-long-term-variation-of-platelet-reactivity-in-patients-with-dual-antiplatelet-therapy-after-myocardial-infarction
#8
Joakim Alfredsson, Eva Swahn, Kerstin M Gustafsson, Magnus Janzon, Lena Jonasson, Elisabeth Logander, Lennart Nilsson, Tomas L Lindahl
There is a large inter-individual variation in response to clopidogrel treatment, and previous studies have indicated higher risk of thrombotic events in those with high residual platelet reactivity (HPR). Less is known about individual variation over time. The aim of this prospective cohort study was to investigate intra-individual variation in platelet reactivity. Platelet aggregation in whole blood was assessed in 77 patients, at 3 days, 8 days and 6 months after admission for acute myocardial infarction and loading dose of clopidogrel...
June 5, 2018: Platelets
https://www.readbyqxmd.com/read/29868850/clinical-implications-of-revised-pooled-cohort-equations-for-estimating-atherosclerotic-cardiovascular-disease-risk
#9
Steve Yadlowsky, Rodney A Hayward, Jeremy B Sussman, Robyn L McClelland, Yuan-I Min, Sanjay Basu
Background: The 2013 pooled cohort equations (PCEs) are central in prevention guidelines for cardiovascular disease (CVD) but can misestimate CVD risk. Objective: To improve the clinical accuracy of CVD risk prediction by revising the 2013 PCEs using newer data and statistical methods. Design: Derivation and validation of risk equations. Setting: Population-based. Participants: 26 689 adults aged 40 to 79 years without prior CVD from 6 U...
June 5, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29862066/continuation-of-aspirin-therapy-before-cataract-surgery-with-different-incisions-safe-or-not
#10
Qingjian Li, Yiwen Qian, Yu Zhang, Gaoyuan Sun, Xian Zhou, Zhiliang Wang
Purpose: To assess whether to continue aspirin therapy while having uncomplicated phacoemulsification cataract surgery with different incisions. Methods: Consecutive patients having cataract surgery under topical anesthesia with different incisions between May 2016 and August 2017 were followed. 236 eyes of 166 patients on routine aspirin therapy were randomized into 2 groups: continuation group, 112 eyes; discontinuation group, 124 eyes. 121 eyes of 94 patients on no routine anticoagulant therapy were used as the control group...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29860330/analgesic-use-and-ovarian-cancer-risk-an-analysis-in-the-ovarian-cancer-cohort-consortium
#11
Britton Trabert, Elizabeth M Poole, Emily White, Kala Visvanathan, Hans-Olov Adami, Garnet L Anderson, Theodore M Brasky, Louise A Brinton, Renee T Fortner, Mia Gaudet, Patricia Hartge, Judith Hoffman-Bolton, Michael Jones, James V Lacey, Susanna C Larsson, Gerardo G Mackenzie, Leo J Schouten, Dale P Sandler, Katie O'Brien, Alpa V Patel, Ulrike Peters, Anna Prizment, Kim Robien, Wendy V Setiawan, Anthony Swerdlow, Piet A van den Brandt, Elisabete Weiderpass, Lynne R Wilkens, Alicja Wolk, Nicolas Wentzensen, Shelley S Tworoger
Background: Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily and low-dose users. To prospectively investigate associations of analgesic use with ovarian cancer, we analyzed data from 13 studies in the Ovarian Cancer Cohort Consortium (OC3). Methods: The current study included 758 829 women who at study enrollment self-reported analgesic use, among whom 3514 developed ovarian cancer...
May 31, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29844732/prospective-study-of-aspirin-for-thromboembolism-prophylaxis-in-total-hip-arthroplasty
#12
Raul Carneiro Lins, Epitácio Leite Rolim, Fernando DE Santa Cruz Oliveira, Saulo Monteiro Dos Santos, Tale Lucas Vieira Rolim, Flávio Kreimer
Objectives: To evaluate the effectiveness of aspirin as prophylaxis for deep venous thrombosis (DVT) in patients undergoing total hip arthroplasty (THA), and to analyze the incidence of bleeding during the post-operative period. Methods: This prospective study carried out in 2017 consisted of 37 patients indicated for THA with high risk for DVT. Immediately after the procedure, aspirin, elastic compression socks and early deambulation were initiated. Doppler ultrasound was performed in the legs 6 days and 6 weeks post-procedure to rule out venous thromboembolism...
March 2018: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/29805582/effects-of-aspirin-on-proliferation-invasion-and-apoptosis-of-hep-2-cells-via-the-pten-akt-nf-%C3%AE%C2%BAb-survivin-signaling-pathway
#13
Mingji Jin, Chunyu Li, Qiang Zhang, Shu Xing, Xuan Kan, Jiayu Wang
Aspirin may exhibit antitumor activities, as it is able to inhibit cell proliferation. However, the ability of aspirin to inhibit cellular proliferation in Hep-2 cells and its underlying molecular mechanisms have been poorly determined. The aim of the present study was to investigate whether aspirin may induce cell apoptosis in the neoplastic cell line Hep-2. The effects of aspirin on the migratory and invasive abilities of Hep-2 cells were also investigated using Transwell assays. In the present study, it was demonstrated that aspirin induced apoptosis and inhibited proliferation, migration and invasion in Hep-2 cells...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29796686/traditional-chinese-medicine-herb-drug-interactions-with-aspirin
#14
Jia Wei Lim, Siow Xian Chee, Wen Jun Wong, Qiu Ling He, Tang Ching Lau
Traditional Chinese medicine (TCM)-based herbal therapies have gained increasing popularity worldwide, raising concerns of its efficacy, safety profile and potential interactions with Western medications. Antithrombotic agents are among the most common prescription drugs involved in herb-drug interactions, and this article focused on aspirin, one of the most widely used antiplatelet agents worldwide. We discussed herbs that have potential interactions by exploring Western and TCM approaches to thrombotic events...
May 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29788460/general-principles-for-pial-synangiosis-in-pediatric-moyamoya-patients-2-dimensional-operative-video
#15
David L Penn, Kyle C Wu, Kayla R Presswood, Coleman P Riordan, R Michael Scott, Edward R Smith
Pial synangiosis is a method of indirect surgical revascularization developed at our institution for the treatment of moyamoya disease in pediatric patients. Similar surgical principles are employed in adult cases, often performed because of lack of an adequate donor vessel. Standardized protocols, including preadmission for preoperative intravenous hydration and aspirin administration, as well as intraoperative electroencephalography, are routinely employed to minimize operative risk. Perioperative heparinization is not required...
May 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29788174/aspirin-abrogates-impairment-of-mammary-gland-differentiation-induced-by-early-in-life-second-hand-smoke-in-mice
#16
Julia Santucci-Pereira, Thomas J Pogash, Aman Patel, Navroop Hundal, Maria Barton, Anna Camoirano, Rosanna T Micale, Sebastiano La Maestra, Roumen Balansky, Silvio De Flora, Jose Russo
Epidemiological studies show that there is limited evidence that tobacco smoking causes breast cancer in humans. In rodents, many tobacco smoke chemicals cause mammary gland tumors. This study evaluated the mammary gland differentiation in mice exposed to environmental cigarette smoke (ECS), using 3R4F Kentucky reference cigarettes, starting after birth and continuing daily for 10 weeks (total particulate exposure 95 mg/m3; CO 610 ppm). We also analyzed the effects of oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin (1600mg/kg) or naproxen (320mg/kg), on mammary gland differentiation, either in unexposed or ECS-exposed mice...
May 17, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29781520/associations-of-candidate-gene-polymorphisms-with-poor-responsiveness-to-aspirin-a-meta-analysis
#17
Juesheng Yang, Xianglai Chen, Jianliang Zhou, Shan Hu, Yanhua Tang
Recently, the roles of gene polymorphisms in poor responsiveness to aspirin were extensively investigated, with conflicting results. Therefore, we performed this meta-analysis to better assess the relationship between candidate genetic variants and poor responsiveness to aspirin. Eligible articles were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to detect possible associations of gene polymorphisms with poor responsiveness to aspirin. Among 53 eligible articles, a total of 22 candidate gene polymorphisms were analyzed...
May 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29779133/heat-stress-induced-renal-damage-in-poultry-and-the-protective-effects-of-hsp60-and-hsp47
#18
Shu Tang, Shuang Zhou, Bin Yin, Jiao Xu, Liangjiao Di, Jinbao Zhang, Endong Bao
The present study investigates the effects of heat stress on the kidney in broilers, based on previous findings which showed that heat stress caused cardiac damage in broilers. Further, the possible renoprotective role of aspirin and the heat shock proteins HSP60 and HSP47 was also investigated. The enzyme levels of urea and uric acid, which are indicators of renal damage, and lactate dehydrogenase, an indicator of oxidative damage, were measured in chickens that were only exposed to heat stress, chickens that were pretreated with aspirin before heat stress, and chickens that were only treated with aspirin...
May 20, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29775206/prospective-determination-of-aspirin-sensitivity-in-patients-resistant-to-low-dose-aspirin-a-proof-of-concept-study
#19
Erica S Westphal, Michelle Rainka, Michelle Amsler, Traci Aladeen, Caitlin Wisniewski, Vernice Bates, Fran M Gengo
This study tested the capability of an assay to predict aspirin response and reduce ischemic events, and healthcare costs, and delays to optimal treatment. Patients who needed aspirin in the course of normal medical care were included. Patients were excluded if they had disorders affecting platelet function, alcohol use within 24 hours of a test, or NSAID use. Dose escalation of chewable aspirin from 81 mg, to 162 mg, to 325 mg daily occurred based on the results of whole blood impedance aggregation testing to the agonists, collagen (1ug/mL, 5 ug/mL) and arachidonate (0...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29775142/aspirin-for-primary-prevention-of-stroke-in-traumatic-cerebrovascular-injury-association-with-increased-risk-of-transfusion
#20
Russell L Griffin, Stephanie R Falatko, Stella Aslibekyan, Virginia Strickland, Mark R Harrigan
OBJECTIVE Blunt traumatic extracranial carotid or vertebral artery injury (i.e., traumatic cerebrovascular injury [TCVI]) occurs in 1%-2% of all blunt trauma admissions, carries a 10% risk of thromboembolic ischemic stroke, and accounts for up to 9600 strokes annually in the US. Screening CT angiograms (CTAs) of patients with trauma has become ubiquitous in recent years, and patients with initially asymptomatic TCVI are commonly treated with antiplatelet agents to prevent stroke. Prophylaxis with antiplatelets is thought to be safer than anticoagulation, which carries a significant risk of hemorrhage in patients with trauma...
May 18, 2018: Journal of Neurosurgery
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