keyword
MENU ▼
Read by QxMD icon Read
search

Superager

keyword
https://www.readbyqxmd.com/read/29896098/associations-of-map2k3-gene-variants-with-superior-memory-in-superagers
#1
Matthew J Huentelman, Ignazio S Piras, Ashley L Siniard, Matthew D De Both, Ryan F Richholt, Chris D Balak, Pouya Jamshidi, Eileen H Bigio, Sandra Weintraub, Emmaleigh T Loyer, M-Marsel Mesulam, Changiz Geula, Emily J Rogalski
Introduction : SuperAgers are adults age 80+ with episodic memory performance that is at least as good as that of average middle-aged adults. Understanding the biological determinants of SuperAging may have relevance to preventing age-related cognitive decline and dementia. This study aimed to identify associations between genetic variations and the SuperAging phenotype using Whole Exome Sequencing (WES). Methods : Sequence Kernel Association Combined (SKAT-C) test was conducted at the gene level including both rare and common variants in 56 SuperAgers and 22 cognitively-average controls from the Alzheimer's disease Neuroimaging Initiative (ADNI)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29753169/chronic-subdural-hematoma-in-patients-aged-80-years-and-older-a-two-centre-study
#2
Pasquale De Bonis, Simone Olei, Lorenzo Mongardi, Michele Alessandro Cavallo, Mariaconsiglia Santantonio, Gianluca Trevisi, Carmelo Anile, Annunziato Mangiola
OBJECTIVE: Chronic subdural hematoma (CSDH) is a common condition in the elderly, and the ageing of population will increase the number of "superaged" patients presenting this pathology for the years to come. Few studies investigating the outcome of superaged patients surgically treated for CSDH are available, and study populations are generally small. The outcome of surgically treated patients and risk factors are not completely clear. Aim of the work is to identify the risk factors which may influence the outcome of patients aged 80 years and older surgically treated for CSDH...
July 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29710004/-paradigm-shift-in-the-quality-of-regional-medical-care-cooperative-treatment-of-onychomycosis
#3
Junko Suzuki, Yoshihiro Imazu, Yoshitaka Yoneta, Katsunori Yamaura, Emiko Uchida
 In a superaging society, the medical paradigm should include both less coverage of medical-care work flow by human resources and high-quality care for patients. Strategies such as establishing medical-care teams and community medicine systems mainly for home medical care should be implemented. However, a well-organized system for home-based medical treatment of elderly patients is not yet in place, as evidenced by the lack of care, problems with long-term polypharmacy resulting from visits to multiple healthcare providers, and declines in their physical strength...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29710003/-role-of-pharmacists-in-topical-therapy-for-onychomycosis-in-the-home-care-setting
#4
Katsunori Yamaura, Naoko Hayashi, Yoshihiro Imazu, Yoshitaka Yoneta, Emiko Uchida, Junko Suzuki
 There is an urgent need to promote home medical care in Japan because of the country's superaging society. Community pharmacists are expected to play an important role as part of home medical care teams. The prevalence of nail ringworm is high among home-care patients and can cause decreases in the quality of life, including difficulty in walking due to pain caused by nail deformation and inflammation around infected nails. Nail ringworm is typically treated with oral medication. However, the condition is left untreated in many elderly patients because of the risk of drug-drug interactions or concerns about severe liver damage...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29435653/epidemiological-trends-in-spine-surgery-over-10-years-in-a-multicenter-database
#5
Kazuyoshi Kobayashi, Kei Ando, Yoshihiro Nishida, Naoki Ishiguro, Shiro Imagama
PURPOSE: There are few epidemiological studies of spinal surgery in Asia and none in Japan. The goal of this study was to review spine surgeries performed in our group between 2004 and 2015 in a cross-sectional study, with a focus on the effects of the superaging society on the characteristics and trends of spinal surgeries. METHODS: A retrospective review was performed for all 45,831 spinal surgeries conducted between 2004 and 2015 and recorded in our prospective multicenter database...
February 12, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29415193/ten-year-experience-of-the-thoraco-abdominal-aortic-aneurysm-treatment-using-a-hybrid-thoracic-endovascular-aortic-repair
#6
Takashi Shuto, Tomoyuki Wada, Shinji Miyamoto, Noritaka Kamei, Norio Hongo, Hiromu Mori
OBJECTIVES: The treatment of thoraco-abdominal aortic aneurysm continues to have a high mortality and paraplegia rate. In superaging societies, the methods of performing less invasive operations remain a major issue. We reviewed our 10-year experience in the treatment of thoraco-abdominal aortic aneurysm using a hybrid procedure of combined visceral reconstruction and thoracic endovascular aortic repair. METHODS: Sixty patients underwent a hybrid repair for the treatment of the thoraco-abdominal aortic aneurysm between 2007 and 2016...
February 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29341318/cognitive-trajectories-and-spectrum-of-neuropathology-in-superagers-the-first-ten-cases
#7
Emily Rogalski, Tamar Gefen, Qinwen Mao, Maureen Connelly, Sandra Weintraub, Changiz Geula, Eileen H Bigio, M-Marsel Mesulam
On average, memory capacity is significantly higher in populations of 50-60 year olds than in populations of 80 year olds. We define SuperAgers as individuals 80 or older whose episodic memory capacity is at least as good as that of cognitively average individuals in their 50s and 60s. SuperAgers therefore have memory capacity that is superior for age. Previous work showed that SuperAgers have greater cortical volumes and greater resistance to age-related cortical atrophy than 'cognitively average' individuals of the same age...
January 17, 2018: Hippocampus
https://www.readbyqxmd.com/read/29175073/von-economo-neurons-of-the-anterior-cingulate-across-the-lifespan-and-in-alzheimer-s-disease
#8
Tamar Gefen, Steven T Papastefan, Aras Rezvanian, Eileen H Bigio, Sandra Weintraub, Emily Rogalski, M-Marsel Mesulam, Changiz Geula
BACKGROUND: Throughout the human aging lifespan, neurons acquire an unusually high burden of wear and tear; this is likely why age is considered the strongest risk factor for the development of Alzheimer's Disease (AD). Von Economo neurons (VENs) are rare, spindle-shaped cells mostly populated in anterior cingulate cortex. In a prior study, "SuperAgers" (individuals older than 80 years of age with outstanding memory ability) showed higher VEN densities compared to elderly controls with average memory, and those with amnestic Mild Cognitive Impairment (aMCI)...
February 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29059208/psychological-well-being-in-elderly-adults-with-extraordinary-episodic-memory
#9
Amanda Cook Maher, Stephanie Kielb, Emmaleigh Loyer, Maureen Connelley, Alfred Rademaker, M-Marsel Mesulam, Sandra Weintraub, Dan McAdams, Regina Logan, Emily Rogalski
OBJECTIVES: The Northwestern University SuperAging Program studies a rare cohort of individuals over age 80 with episodic memory ability at least as good as middle-age adults to determine what factors contribute to their elite memory performance. As psychological well-being is positively correlated with cognitive performance in older adults, the present study examined whether aspects of psychological well-being distinguish cognitive SuperAgers from their cognitively average-for-age, same-age peers...
2017: PloS One
https://www.readbyqxmd.com/read/28686232/superaging-the-new-phrenology-and-the-gluten-free-diet-for-the-brain
#10
Joseph H Friedman
No abstract text is available yet for this article.
July 5, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28334147/variations-in-acetylcholinesterase-activity-within-human-cortical-pyramidal-neurons-across-age-and-cognitive-trajectories
#11
Monica Janeczek, Tamar Gefen, Mehrnoosh Samimi, Garam Kim, Sandra Weintraub, Eileen Bigio, Emily Rogalski, M-Marsel Mesulam, Changiz Geula
We described an extensive network of cortical pyramidal neurons in the human brain with abundant acetylcholinesterase (AChE) activity. Emergence of these neurons during childhood/adolescence, attainment of highest density in early adulthood, and virtual absence in other species led us to hypothesize involvement of AChE within these neurons in higher cortical functions. The current study quantified the density and staining intensity of these neurons using histochemical procedures. Few faintly stained AChE-positive cortical pyramidal neurons were observed in children/adolescents...
April 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/27629716/youthful-brains-in-older-adults-preserved-neuroanatomy-in-the-default-mode-and-salience-networks-contributes-to-youthful-memory-in-superaging
#12
Felicia W Sun, Michael R Stepanovic, Joseph Andreano, Lisa Feldman Barrett, Alexandra Touroutoglou, Bradford C Dickerson
UNLABELLED: Decline in cognitive skills, especially in memory, is often viewed as part of "normal" aging. Yet some individuals "age better" than others. Building on prior research showing that cortical thickness in one brain region, the anterior midcingulate cortex, is preserved in older adults with memory performance abilities equal to or better than those of people 20-30 years younger (i.e., "superagers"), we examined the structural integrity of two large-scale intrinsic brain networks in superaging: the default mode network, typically engaged during memory encoding and retrieval tasks, and the salience network, typically engaged during attention, motivation, and executive function tasks...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26728541/-topics-for-translational-research
#13
Atsushi Suzuki
This report focused on translational research presented in ASBMR 2015 held in Seattle, WA in October 2015. Comorbidity with chronic diseases such as diabetes and chronic kidney disease and the relationship between skeletal and extraskeltal tissues give us more complexed pathophysiological issues to be clarified in superaged society.
January 2016: Clinical Calcium
https://www.readbyqxmd.com/read/25632151/morphometric-and-histologic-substrates-of-cingulate-integrity-in-elders-with-exceptional-memory-capacity
#14
Tamar Gefen, Melanie Peterson, Steven T Papastefan, Adam Martersteck, Kristen Whitney, Alfred Rademaker, Eileen H Bigio, Sandra Weintraub, Emily Rogalski, M-Marsel Mesulam, Changiz Geula
This human study is based on an established cohort of "SuperAgers," 80+-year-old individuals with episodic memory function at a level equal to, or better than, individuals 20-30 years younger. A preliminary investigation using structural brain imaging revealed a region of anterior cingulate cortex that was thicker in SuperAgers compared with healthy 50- to 65-year-olds. Here, we investigated the in vivo structural features of cingulate cortex in a larger sample of SuperAgers and conducted a histologic analysis of this region in postmortem specimens...
January 28, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/25215637/inhibitors-of-factor-xiii-13-in-older-patients
#15
REVIEW
Akitada Ichinose
Factor XIII/13 (FXIII or F13) is a plasma protransglutaminase, which stabilizes fibrin clots, and thus plays an important role in hemostasis. Autoimmune hemo(rrha)philia due to anti-F13 autoantibodies (AH13) has been on the rise in Japan, which has become the leading superaging society in the 21st century. The mean age of Japanese AH13 cases has risen to 70.4 years. A total of 83 AH13 cases have been diagnosed in the world as of July 2014. To raise the awareness of AH13, the author and members of the Japanese Collaborative Research Group first proposed "Criterion and Algorithm of Laboratory Tests for anti F13" in February 2012...
September 2014: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/23718975/-who-healthy-city-initiative-in-japan
#16
Kazuko Yoshizawa
City environmental conditions are associated with health outcomes in people living there. World Health Organization (WHO) initiated Healthy City in 1986. To promote the networking, Alliance for Healthy Cities (AFHC) was launched in 2003 with local offices including AFHC Japan. As of 2010, 26 cities are members of AFHC Japan. A questionnaire was sent to those member cities. It includes questions on why they became an AFHC member, which section is in charge of the initiatives, what factors are important for promotion, and others...
2013: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/23652092/sequencing-of-superagers-offers-drug-targets-but-fewer-than-hoped
#17
Kevin Jiang
No abstract text is available yet for this article.
May 2013: Nature Medicine
https://www.readbyqxmd.com/read/23198888/youthful-memory-capacity-in-old-brains-anatomic-and-genetic-clues-from-the-northwestern-superaging-project
#18
Emily J Rogalski, Tamar Gefen, Junzi Shi, Mehrnoosh Samimi, Eileen Bigio, Sandra Weintraub, Changiz Geula, M-Marsel Mesulam
The Northwestern University SuperAging Project recruits community dwellers over the age of 80 who have unusually high performance on tests of episodic memory. In a previous report, a small cohort of SuperAgers was found to have higher cortical thickness on structural MRI than a group of age-matched but cognitively average peers. SuperAgers also displayed a patch of ACC where cortical thickness was higher than in 50- to 60-year-old younger cognitively healthy adults. In additional analyses, some SuperAgers had unusually low densities of age-related Alzheimer pathology and unusually high numbers of von Economo neurons in the anterior cingulate gyrus...
January 2013: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/23158231/superior-memory-and-higher-cortical-volumes-in-unusually-successful-cognitive-aging
#19
Theresa M Harrison, Sandra Weintraub, M-Marsel Mesulam, Emily Rogalski
It is "normal" for old age to be associated with gradual decline in memory and brain mass. However, there are anecdotal reports of individuals who seem immune to age-related memory impairment, but these individuals have not been studied systematically. This study sought to establish that such cognitive SuperAgers exist and to determine if they were also resistant to age-related loss of cortical brain volume. SuperAgers were defined as individuals over age 80 with episodic memory performance at least as good as normative values for 50- to 65-year-olds...
November 2012: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/23004720/superaging-correlation-function-and-ergodicity-breaking-for-brownian-motion-in-logarithmic-potentials
#20
A Dechant, E Lutz, D A Kessler, E Barkai
We consider an overdamped Brownian particle moving in a confining asymptotically logarithmic potential, which supports a normalized Boltzmann equilibrium density. We derive analytical expressions for the two-time correlation function and the fluctuations of the time-averaged position of the particle for large but finite times. We characterize the occurrence of aging and nonergodic behavior as a function of the depth of the potential, and we support our predictions with extensive Langevin simulations. While the Boltzmann measure is used to obtain stationary correlation functions, we show how the non-normalizable infinite covariant density is related to the superaging behavior...
May 2012: Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
keyword
keyword
120245
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"