Maike Y Adler, Insaf Issoual, Michael Rückert, Lisa Deloch, Carola Meier, Thomas Tschernig, Christoph Alexiou, Felix Pfister, Anja Frm Ramsperger, Christian Laforsch, Udo S Gaipl, Katharina Jüngert, Friedrich Paulsen
Micro- and nanoplastics (MNPs) are ubiquitous in the environment, resulting in the uptake of MNPs by a variety of organisms, including humans, leading to particle-cell interaction. Human macrophages derived from THP-1 cell lines take up Polystyrene (PS), a widespread plastic. The question therefore arises whether primary human macrophages also take up PS micro- and nanobeads (MNBs) and how they react to this stimulation. Major aim of this study is to visualize this uptake and to validate the isolation of macrophages from peripheral blood mononuclear cells (PBMCs) to assess the impact of MNPs on human macrophages...
April 11, 2024: Journal of Hazardous Materials