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Particle size+ effect

Cuiping Yu, Yue Cha, Fan Wu, Xianbing Xu, Ming Du
In this study, the effects of limited hydrolysis and/or high-pressure homogenization (HPH) treatment in acid conditions on the functional properties of oyster protein isolates (OPI) were studied. Protein solubility, surface hydrophobicity, particle size distribution, zeta potential, foaming, and emulsifying properties were evaluated. The results showed that acid treatment led to the dissociation and unfolding of OPI. Subsequent treatment such as limited proteolysis, HPH, and their combination remarkably improved the functional properties of OPI...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Songcheng Wang, Yi Zhang, J Carson Meredith, Sven H Behrens, Manoj Kumar Tripathi, Kirti Chandra Sahu
Air bubbles rising through an aqueous medium have been studied extensively and are routinely used for the separation of particulates via froth flotation, a key step in many industrial processes. Oil-coated bubbles can be more effective for separating hydrophilic particles with low affinity for the air-water interface, but the rise dynamics of oil-coated bubbles has not yet been explored. In the present work, we report the first systematic study of the shape and rise trajectory of bubbles engulfed in a layer of oil...
March 22, 2018: Soft Matter
Jiayuan Zhao, Jordan Nelson, Oluwabunmi Dada, Georgios Pyrgiotakis, Ilias G Kavouras, Philip Demokritou
Users of electronic cigarettes (e-cigs) are exposed to particles and other gaseous pollutants. However, major knowledge gaps on the physico-chemical properties of such exposures and contradictory data in published literature prohibit health risk assessment. Here, the effects of product brand, type, e-liquid flavoring additives, operational voltage, and user puffing patterns on emissions were systematically assessed using a recently developed, versatile, e-cig exposure generation platform and state-of-the-art analytical methods...
March 22, 2018: Inhalation Toxicology
Henok D Belayneh, Randy L Wehling, Yue Zhang, Ozan N Ciftci
Camelina sativa seed is an underutilized oil source rich in omega-3 fatty acids; however, camelina oil is not fully explored for food applications. Its high omega-3 content makes it susceptible to oxidation, which may limit food applications. Therefore, the main objective of this study was to investigate the potential of camelina seed oil to form physically and oxidatively stable emulsions as a potential delivery system for omega-3 fatty acids. Effects of homogenization conditions, namely, pressure (15 MPa-30 MPa), number of passes (1,3,5, and 7), and type of homogenizers (high pressure and high shear) on the structural properties and stability of camelina seed oil emulsions stabilized with whey protein isolate were studied...
March 2018: Food Science & Nutrition
Maryam Kalantari, Mehrdad Niakousari, Soroush Haghighi-Manesh, Mehrdad Rasouli
This study aims to optimize extraction and drying conditions of fig syrup. Drying was done in a pilot scale two-fluid nozzle spray dryer. A total of 27 experiments were conducted with varying inlet air temperatures, air flow rates, and also a maltodextrin (MD)- low methoxyl pectin (LMP) ratios. While feed rate, feed temperature, and compressed air flow rate of the atomizer were kept constant. The results of differential scanning calorimetry revealed that high levels of glucose and fructose in the extract resulted in a low glass transition temperature of fig syrup...
March 2018: Food Science & Nutrition
Xingmei Duan, Minjie Mu, Junfeng Yan, Lan Bai, Lei Zhong, Yuxuan Zhu, Haixia Pan, Mei Zhang, Jianyou Shi
Background: The newly synthesized Aurora-A kinase inhibitor XY-4 is a potential anti-cancer agent, but its hydrophobicity and limited efficiency restrict further application. Nanotechnology based combined therapy provides an optimized strategy for solving these issues. Methods: In this study, the newly synthesized Aurora-A kinase inhibitor XY-4 and Bcl-xl targeted siRNA were co-delivered by cationic liposomes, creating an injectable co-delivery formulation. The anti-cancer ability and mechanisms of XY-4/Bcl-xl siRNA co-loaded cationic liposomes were studied both in vitro and in vivo...
2018: International Journal of Nanomedicine
Noha M Badawi, Mahmoud H Teaima, Khalid M El-Say, Dalia A Attia, Mohamed A El-Nabarawi, Mohey M Elmazar
Background: Pomegranate extract (PE) is a natural product with potent antioxidant and anticancer activity because of its polyphenols content. The main purpose of this study was to maximize the PE chemotherapeutic efficacy by loading it in an optimized solid lipid nanoparticles (SLNs) formula. Materials and methods: The influence of independent variables, which were lipid concentration (X1 ), surfactant concentration (X2 ) and cosurfactant concentration (X3 ), on dependent ones, which were particle size (Y1 ), polydispersity index (Y2 ), zeta potential (Y3 ), entrapment efficiency (Y4 ) and cumulative % drug release (Y5 ), were studied and optimized using the Box-Behnken design...
2018: International Journal of Nanomedicine
Xinya Wang, Changfa Xiao, Hailiang Liu, Qinglin Huang, Junqiang Hao, Hao Fu
Poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) porous membranes are fabricated via thermally induced phase separation (TIPS) with mixed diluent (dibutyl phthalate (DBP)/dioctyl phthalate (DOP)). The effects of mixed diluent are discussed in detail in term of morphology, mean pore size, selective wettability, etc. The results show that the membrane structure changes from spherulitic to bicontinuous with the change of DBP/DOP ratio. It is also found that the degree of crystallization decreases with the decrease of DBP/DOP ratio in mixed diluent...
March 18, 2018: Materials
Bayan Alemrayat, Abdelbary Elhissi, Husam M Younes
Letrozole (LTZ), an aromatase inhibitor used for the treatment of hormonally-positive breast cancer in postmenopausal women, has poor water solubility, rapid metabolism and a range of side effects. In this study, polymer-based nanoparticles (NPs) incorporating the drug have been designed and characterized, aimed to control the release, potentially maximize the therapeutic efficiency and minimize the side effects of the drug. LTZ was incorporated into Poly (D, L-Lactide) (PDLLA) NPs by employing the emulsion-solvent evaporation technique using a range of drug concentrations...
March 21, 2018: Pharmaceutical Development and Technology
Li Wan, Hongyuan Song, Junhao Ma, Yuan Ren, Xiaowei Cheng, Jiacan Su, Qin Yue, Yonghui Deng
Iron oxide materials have wide applications due to their special physicochemical properties; however, it is a great challenge to synthesize mesoporous iron oxide based microspheres conveniently and controllably with high surface area, large pore volume and interconnected porous structures. Herein, mesoporous α-Fe2O3 based microspheres with high porosity are synthesized via a facile polymerization induced colloid assembly (PICA) method through polymerization of urea-formaldehyde resin (UF resin) and its simultaneously cooperative assembly with Fe(OH)3 colloids in aqueous solution, followed with subsequent thermal treatment...
March 21, 2018: ACS Applied Materials & Interfaces
Yi Zhang, Jielin Pan, Qilan Xu, Hao Li, Jianhao Wang, Chao Zhang, Guobin Hong
Objective: To construct carcinoma vascular endothelial-targeted polymeric nanomicelles with high magnetic resonance imaging (MRI) sensitivity and to evaluate their biological safety and in vitro tumor-targeting effect, and to monitor their feasibility using clinical MRI scanner. Method: Amphiphilic block copolymer, poly(ethylene glycol)- b -poly(ε-caprolactone) (PEG-PCL) was synthesized via the ring-opening polymerization of ε-caprolactone (CL) initiated by poly(ethylene glycol) (PEG), in which cyclic pentapeptide Arg-Gly-Asp (cRGD) was conjugated with the terminal of hydrophilic PEG block...
2018: International Journal of Medical Sciences
Xingxing Shi, Kai Zhou, Fei Huang, Juan Zhang, Chen Wang
Background: As a potentially bioactive material, the widespread application of nanosized hydroxyapatite (nano-HAP) in the field of bone regeneration has increased the risk of human exposure. However, our understanding of the interaction between nano-HAP and stem cells implicated in bone repair remains incomplete. Methods: Here, we characterized the adhesion and cellular internalization of HAP nanoparticles (HANPs) with different sizes (20 nm np20 and 80 nm np80) and highlighted the involved pathway in their uptake using human umbilical cord Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs)...
2018: International Journal of Nanomedicine
Sarbast K Kheravii, Robert A Swick, Mingan Choct, Shu-Biao Wu
BACKGROUND: Measures to improve bird performance have been sought due to the imminent phase out of in-feed antibiotics in poultry and continued demand for higher poultry feeding efficiency. Increasing grain particle size and dietary fibre may improve gizzard function, digestive efficiency and nutrient absorption. This study was conducted to evaluate the effect increased particle size of corn and inclusion of sugarcane bagasse (SB) on mRNA expression of genes encoding digestive enzymes and nutrient transporters in broilers...
March 20, 2018: BMC Genomics
Zhulan Gu, Shumin Li, Zhiping Xiong, Hui Xu, Fei Gao, Yukou Du
Bimetallic nanocatalysts with small particle size benefit from markedly enhanced electrocatalytic activity and stability during small molecule oxidation. Herein, we report a facile method to synthesize binary Pt-Ru nanoparticles dispersed on a carbon support at an optimum temperature. Because of its monodispersed nanostructure, synergistic effects were observed between Pt and Ru and the PtRu/C electrocatalysts showed remarkably enhanced electrocatalytic activity towards ethanol oxidation. The peak current density of the Pt1 Ru1 /C electrocatalyst is 3731 mA mg-1 , which is 9...
March 13, 2018: Journal of Colloid and Interface Science
Aftab Ahmad, Mohammed F Abuzinadah, Huda M Alkreathy, Babajan Banaganapalli, Mohd Mujeeb
BACKGROUND: Ursolic acid (UA) is a promising molecule with anti-inflammatory, analgesic and potential anti-arthritic activity. METHODS: This study was undertaken to make formulation and evaluation of Ocimum sanctum L. leaf extract (OLE) loaded nano-structured lipid carriers (OLE-NLCs) for improved transdermal delivery of UA. Different surfactants, solid lipids and liquid lipids were used for the preparation of NLCs. The NLCs were developed using emulsion solvent diffusion and evaporation method...
2018: PloS One
Qiaoxian Huang, Shengke Li, Yuan-Fu Ding, Hang Yin, Lian-Hui Wang, Ruibing Wang
Due to its outstanding capability to facilitate DNA condensation, transportation and endosomal escape, polyethylenimine (PEI) has been frequently studied for gene delivery. However, its molecular weight (M.W.) dependent transfection efficiency and cytotoxicity has severely limited its clinical application. To resolve this dilemma, a supramolecular strategy was developed for the first time, in which PEI with large M.W. (branched, 25 kDa) that has a satisfactory transfection efficiency, yet high non-specific cytotoxicity for gene delivery was wrapped with macrocyclic cucurbit[7]uril (CB[7])...
March 20, 2018: Biomaterials Science
Diana E Aziz, Aly A Abdelbary, Abdelhalim I Elassasy
Diacerein (DCN) is a hydrophobic osteoarthritis (OA) drug with short half-life and low oral bioavailability. Furthermore, DCN oral administration is associated with diarrhea which represents obstacle against its oral use. Hence, this article aimed at developing elastosomes (edge activator (EA)-based vesicular nanocarriers) as a novel transdermal system for delivering DCN efficiently and avoiding its oral problems. For achieving this goal, elastosomes were prepared according to 41 .21 full factorial design using different EAs in varying amounts...
November 2018: Drug Delivery
Alex H F Lee, Steven F Gessert, Yutao Chen, Nikolay V Sergeev, Babak Haghiri
In this work, a robust synthetic pathway for magnetic core preparation and silica surface coating of magnetic microparticles is presented. Silica-coated magnetic particles are widely used to extract DNA and RNA from various biological samples. We present a novel route for the synthesis of iron oxide silica particles (Fe3 O4 @Silica) and demonstrate their performance for extracting ZIKA viral RNA from serum. The iron (II, III) oxide (Fe3 O4 ), magnetite core is first prepared by ammonia neutralization of ferrous and ferric chloride aqueous solution under argon, followed by the addition of citrate salt to stabilize the surface of the resultant magnetic nanospheres...
March 2018: Heliyon
Hongyun Zhao, Meng Wu, Leilei Zhu, Yi Tian, Mingxing Wu, Yizhen Li, Liming Deng, Wei Jiang, Wei Shen, Zhigang Wang, Zhechuan Mei, Pan Li, Haitao Ran, Zhiyi Zhou, Jianli Ren
Objective: Prepare a multifunctional ultrasound molecular probe, hyaluronic acid-mediated cell-penetrating peptide-modified 10-hydroxycamptothecin-loaded phase-transformation lipid nanoparticles (HA/CPPs-10-HCPT-NPs), and to combine HA/CPPs-10-HCPT-NPs with low-intensity focused ultrasound (LIFU) for precision theranostics against hepatocellular carcinoma (HCC). Methods: HA/CPPs-10-HCPT-NPs were prepared using thin-film dispersion, ultrasound emulsification, and electrostatic effects. HA/CPPs-10-HCPT-NPs were characterized for particle size, zeta potential, encapsulation efficiency and drug-loading efficiency...
2018: Theranostics
Yücel Baspinar, Mehmet Üstündas, Oguz Bayraktar, Canfeza Sezgin
Curcumin as the active compound of turmeric has antioxidative, antiinflammatory, antimicrobial and anticancer properties among others. However, its disadvantageous properties like low solubility, poor bioavailability and rapid degradation under neutral or alkaline pH conditions or when exposed to light limit its clinical application. These problems can be solved by a smart combination of using a natural enhancer like piperine and preparing nanoparticles by a proper method like electrospray. Due to these facts it was aimed in this study to develop curcumin and piperine loaded zein-chitosan nanoparticles step by step...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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