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Fetal healing

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https://www.readbyqxmd.com/read/28642867/evaluation-of-the-effect-of-a-single-intra-articular-injection-of-allogeneic-neonatal-mesenchymal-stromal-cells-compared-to-oral-non-steroidal-anti-inflammatory-treatment-on-the-postoperative-musculoskeletal-status-and-gait-of-dogs-over-a-6-month-period-after
#1
Mathieu Taroni, Quentin Cabon, Marine Fèbre, Thibaut Cachon, Nathalie Saulnier, Claude Carozzo, Stéphane Maddens, Fabrice Labadie, Clément Robert, Eric Viguier
OBJECTIVE: Compare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs). STUDY DESIGN: Prospective, double-blinded, randomized, controlled, monocentric clinical study...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28627609/microrna-149-contributes-to-scarless-wound-healing-by-attenuating-inflammatory-response
#2
Hongxin Lang, Feng Zhao, Tao Zhang, Xiaoyu Liu, Zhe Wang, Rui Wang, Ping Shi, Xining Pang
A fibrotic or pathological scar is an undesired consequence of skin wound healing and may trigger a series of problems. An attenuated inflammatory response is a significant characteristic of fetal skin wound healing, which can contribute to the scarless healing of fetal skin. According to deep sequencing data, microRNA‑149 (miR‑149) expression was increased in mid-gestational compared with that in late‑gestational fetal skin keratinocytes. It was demonstrated that overexpression of miR‑149 in HaCaT cells can downregulate the expression of pro‑inflammatory cytokines interleukin (IL)‑1α, IL‑1β, and IL‑6 at basal levels and in inflammatory conditions...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28575912/-growth-factor-concentration-in-keratocyte-supernatant-after-incubation-with-human-serum-in-vitro
#3
Nóra Szentmáry, Tanja Stachon, Ming-Feng Wu, Mona Bischoff, Manuela Huber, Achim Langenbucher, Berthold Seitz
Purpose Application of serum eye drops is an alternative treatment option for therapy-resistant corneal epithelial defects. In case of persisting epithelial defects, cytokines, which are secreted from stromal keratocytes, may play a role in epithelial wound healing. Our aim was to analyze fibroblast growth factor basic (FGFb), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) and transforming growth factor β1 (TGF-β1) concentration in the supernatant of keratocytes, after incubation with human serum (HS)...
June 2, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28553231/hydroxysafflor-yellow-a-suppresses-mrc-5-cell-activation-induced-by-tgf-%C3%AE-1-by-blocking-tgf-%C3%AE-1-binding-to-t%C3%AE-rii
#4
Ruiyan Pan, Yadan Zhang, Meng Zheng, Baoxia Zang, Ming Jin
Hydroxysafflor yellow A (HSYA) is an active ingredient of Carthamus tinctorius L.. This study aimed to evaluate the effects of HSYA on transforming growth factor-β1 (TGF-β1)-induced changes in proliferation, migration, differentiation, and extracellular matrix accumulation and degradation in human fetal lung fibroblasts (MRC-5), to explore the mechanisms whereby HSYA may alleviate pulmonary fibrosis. MRC-5 cells were incubated with various doses of HSYA and/or the TGF-β receptor type I kinase inhibitor SB431542 and then stimulated with TGF-β1...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28538572/intratendinous-injection-of-hydrogel-for-reseeding-decellularized-human-flexor-tendons
#5
Chao Long, Michael G Galvez, Anais Legrand, Lydia-Marie Joubert, Zhen Wang, Arhana Chattopadhyay, James Chang, Paige M Fox
BACKGROUND: Decellularized cadaveric tendons are a potential source for reconstruction. Reseeding to enhance healing is ideal; however, cells placed on the tendon surface result in inadequate delivery. The authors used an injection technique to evaluate intratendinous cell delivery. METHODS: Decellularized tendons were reseeded with adipose-derived stem cells in culture, and injected with fetal bovine serum or hydrogel. PKH26-stained cells in cross-section were quantified...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28535522/restenosis-in-hemodialytic-fistulas-and-chronic-kidney-disease-associated-vascular-disease-two-pathologies-driven-by-metakaryotic-stem-cells
#6
Gianandrea Pasquinelli, William G Thilly, Elena V Gostjeva, Paola Todeschini, Giuseppe Cianciolo, Claudio Ronco, Gaetano La Manna
Chronic kidney disease (CKD) exacerbating vascular disease poses a major challenge to nephrology. Surgically placed vascular fistulas, as an aid to hemodialysis prior to kidney transplant, have extended many lives, while post-surgical restenosis closure of the fistula by smooth muscle cells affects many lives. When post-surgical restenosis is developed, palliative measures are almost always surgical: there are no effective drug treatments. In this study, we offer a testable hypothesis that effects of CKD on widely distributed vascular diseases and the phenomenon of fistula restenosis are both driven by the pathologic creation of non-dividing smooth muscle cells via asymmetric division of exponentially increasing metakaryotic stem cells...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28516946/ccl2-ccr2-signalling-recruits-a-distinct-fetal-microchimeric-population-that-rescues-delayed-maternal-wound-healing
#7
Mathieu Castela, Dany Nassar, Maria Sbeih, Marie Jachiet, Zhe Wang, Selim Aractingi
Foetal microchimeric cells (FMCs) traffic into maternal circulation during pregnancy and persist for decades after delivery. Upon maternal injury, FMCs migrate to affected sites where they participate in tissue healing. However, the specific signals regulating the trafficking of FMCs to injury sites had to be identified. Here we report that, in mice, a subset of FMCs implicated in tissue repair displays CD11b(+) CD34(+) CD31(+) phenotype and highly express C-C chemokine receptor 2 (Ccr2). The Ccr2 ligand chemokine ligand 2 (Ccl2) enhances the recruitment of FMCs to maternal wounds where these cells transdifferentiate into endothelial cells and stimulate angiogenesis through Cxcl1 secretion...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28509317/morphology-of-the-cesarean-section-scar-in-the-non-pregnant-uterus-after-one-elective-cesarean-section
#8
Michał Pomorski, Tomasz Fuchs, Anna Rosner-Tenerowicz, Mariusz Zimmer
OBJECTIVES: A growing number of studies suggest that the incomplete healing of the CS scar in the uterus increase the risk of uterine dehiscence or rupture during subsequent pregnancies. Thus, the factors that affect wound healing should be evaluated. We aimed to determine whether the morphology of the CS scar in non-pregnant women after one elective CS was affected by the site of the uterine incision, uterine flexion, maternal age, and fetal birth weight. MATERIAL AND METHODS: 208 non-pregnant women were invited for participation in the study, but only 101 of them met inclusion criteria...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28480995/aplasia-cutis-congenita-type-v-a-case-report-and-review-of-the-literature
#9
REVIEW
Benjamin M Perry, Cory B Maughan, Matthew S Crosby, Scott D Hadenfeld
Aplasia cutis congenita (ACC) is a relatively rare congenital anomaly that most commonly occurs as a solitary cutaneous defect on the scalp. Depth of involvement varies, and involvement of deeper calvarium and dural structures can be seen in more severe cases. Multiple classification systems have been devised with the Frieden Classification System being the most widely adopted. Using this system, we describe a patient that developed Type V ACC with associated fetal papyraceous. The child healed remarkably well with the application of petrolatum impregnated gauze and topical silver sulfadiazine twice daily for approximately 4 weeks...
May 8, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28479722/influence-of-capsaicin-on-inflammatory-cytokines-induced-by-lipopolysaccharide-in-myoblast-cells-under-in-vitro-environment
#10
Ke Shang, Touseef Amna, Musarat Amina, Nawal M Al-Musayeib, Salem S Al-Deyab, Inho Hwang
BACKGROUND: ellular damage initiated by reactive oxygen species (ROS) is the main cause of numerous severe diseases and therefore for this reason, the natural antioxidants have note worthy significance in human health. Capsaicin possesses noteworthy analgesic and anti-inflammatory properties. It also possesses healing effects for treatment of arthritis, diabetic neuropathy, gastric lesions, and cardiac excitability that is why it is incorporated in creams and gels. OBJECTIVE: The present study was carried out to estimate the in vitro antioxidant and ROS scavenging activities of capsaicin against muscle precursor cells...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28439897/platelet-lysate-obtained-via-plateletpheresis-performed-in-standing-and-awake-equine-donors
#11
Scarlett M Sumner, Maria C Naskou, Merrilee Thoresen, Ian Copland, John F Peroni
BACKGROUND: Platelet preparations containing growth factors, attachment factors, and enzymes are appealing to enhance healing of injured tissues and as an alternative to xenogenic serum in cell culture media. Plateletpheresis is commonly used to collect platelets in human medicine but has not been validated in horses. STUDY DESIGN AND METHODS: Plateletpheresis to collect platelet concentrate was performed on six female, mixed breed, chemically restrained horses using commercially available apheresis equipment...
April 25, 2017: Transfusion
https://www.readbyqxmd.com/read/28437592/cover-image-volume-232-number-8-august-2017
#12
Anjali Somal, Irfan A Bhat, Indu B, Anuj P Singh, Bibhudatta S K Panda, Perumal A Desingu, Sriti Pandey, Mukesh K Bharti, Amar Pal, Guttula Saikumar, Vikash Chandra, Guttula Taru Sharma
Cover: The cover image, by Guttula Taru Sharma et al., is based on the Original Research Article Impact of Cryopreservation on Caprine Fetal Adnexa Derived Stem Cells and Its Evaluation for Growth Kinetics, Phenotypic Characterization, and Wound Healing Potential in Xenogenic Rat Model, DOI: 10.1002/jcp.25731.
August 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28428904/salvage-of-necrotic-appearing-limb-after-in-utero-endoscopic-lysis-of-constriction-bands
#13
M Abdel-Sattar, A Chon, B Chen, W Burkhalter, R H Chmait
We report a case of amniotic band syndrome complicated by constriction bands and marked distal swelling of both lower extremities. Color Doppler interrogation of the right lower extremity revealed complete lack of blood flow below the level of the constriction. Upon fetoscopic survey, the right lower extremity beyond the constriction band appeared dusky red and discolored with desquamation, consistent with a necrotic appearance. The constriction bands were cut in utero using endoshears, thereby allowing restoration of blood flow on postoperative day 1...
April 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28338216/the-diversified-function-and-potential-therapy-of-ectopic-olfactory-receptors-in-non-olfactory-tissues
#14
Zhe Chen, Hong Zhao, Nian Fu, Linxi Chen
Olfactory receptors (ORs) are mainly distributed in olfactory neurons and play a key role in detecting volatile odorants, eventually resulting in the production of smell perception. Recently, it is also reported that ORs are expressed in non-olfactory tissues including heart, lung, sperm, skin, and cancerous tissues. Interestingly, ectopic ORs are associated with the development of diseases in non-olfactory tissues. For instance, ectopic ORs initiate the hypoxic ventilatory responses and maintain the oxygen homeostasis of breathing in the carotid body when oxygen levels decline...
March 24, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28319828/genistein-affects-proliferation-and-migration-of-bovine-oviductal-epithelial-cells
#15
Daniela C García, Pablo A Valdecantos, Dora C Miceli, Mariela Roldán-Olarte
Genistein is one of the most abundant isoflavones in soybean. This molecule induces cell cycle arrest and apoptosis in different normal and cancer cells. Genistein has been of considerable interest due to its adverse effects on bovine reproduction, altering estrous cycle, implantation and fetal development and producing subfertility or infertility. The objective of this work was to study the effects of genistein on the expression of selected genes involved in the regulation of cell cycle and apoptosis. Primary cultures of bovine oviductal epithelial cells (BOEC) were treated with different genistein concentrations (0...
March 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28266180/serum-from-plasma-rich-in-growth-factors-regenerates-rabbit-corneas-by-promoting-cell-proliferation-migration-differentiation-adhesion-and-limbal-stemness
#16
Jaime Etxebarria, Sara Sanz-Lázaro, Raquel Hernáez-Moya, Vanesa Freire, Juan A Durán, María-Celia Morales, Noelia Andollo
PURPOSE: To evaluate the regenerating potential and the mechanisms through which the autologous serum derived from plasma rich in growth factors (s-PRGF) favours corneal wound healing in vitro and in vivo. METHODS: We compared the effect of various concentrations of s-PRGF versus fetal bovine serum (FBS) and control treatment in rabbit primary corneal epithelial and stromal cells and wounded rabbit corneas. Cell proliferation was measured using an enzymatic colorimetric assay...
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28238941/theoretical-and-practical-aspects-of-using-fetal-fibroblasts-for-skin-regeneration
#17
REVIEW
Meirong Li, Yali Zhao, Haojie Hao, Weidong Han, Xiaobing Fu
Cutaneous wounding in late-gestational fetal or postnatal humans results in scar formation without any skin appendages. Early or mid- gestational skin healing in humans is characterized by the absence of scaring in a process resembling regeneration. Tremendous cellular and molecular mechanisms contribute to this distinction, and fibroblasts play critical roles in scar or scarless wound healing. This review discussed the different repair mechanisms involved in wound healing of fibroblasts at different developmental stages and further confirmed that fetal fibroblast transplantation resulted in reduced scar healing in vivo...
February 24, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28216888/effect-of-absolute-from-hibiscus-syriacus-l-flower-on-wound-healing-in-keratinocytes
#18
Seok Won Yoon, Kang Pa Lee, Do-Yoon Kim, Dae Il Hwang, Kyung-Jong Won, Dae Won Lee, Hwan Myung Lee
BACKGROUND: Proliferation and migration of keratinocytes are essential for the repair of cutaneous wounds. Hibiscus syriacus L. has been used in Asian medicine; however, research on keratinocytes is inadequate. OBJECTIVE: To establish the dermatological properties of absolute from Hibiscus syriacus L. flower (HSF) and to provide fundamental research for alternative medicine. MATERIALS AND METHODS: We identified the composition of HSF absolute using gas chromatography-mass spectrometry analysis...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28205096/pharmacological-effects-of-asiatic-acid-in-glioblastoma-cells-under-hypoxia
#19
Flourina Kumar Thakor, Ka-Wai Wan, Philip John Welsby, Gail Welsby
Glioblastoma multiforme is the most common and malignant primary brain tumor in adults. Despite current treatment options including surgery followed by radiation and chemotherapy with temozolomide and cisplatin, the median survival rate remains low (<16 months). Combined with increasing drug resistance and the inability of some compounds to cross the blood-brain barrier, novel compounds are being sought for the treatment of this disease. Here, we aimed to examine the pharmacological effect of Asiatic acid (AA) in glioblastoma under hypoxia...
June 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28183603/chitosan-%C3%AE-1-3-glucan-hydroxyapatite-bone-scaffold-enhances-osteogenic-differentiation-through-tnf-%C3%AE-mediated-mechanism
#20
Agata Przekora, Grazyna Ginalska
The role of TNF-α in bone healing process is still unclear and controversial. Although it is commonly believed that TNF-α inhibits osteogenic differentiation, there are few reports that identified a crucial role of TNF-α in enhancing bone regeneration process. The aim of this study was to prove that novel chitosan/β-1,3-glucan/HA scaffold (chit/glu/HA) may promote osteogenic differentiation via TNF-α-mediated mechanism and an autocrine stimulation of osteoblasts. It was demonstrated that normal human fetal osteoblasts (hFOB 1...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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