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https://www.readbyqxmd.com/read/28446135/comparison-of-rapid-immunoassays-for-rupture-of-fetal-membranes
#1
Irogue Igbinosa, Ferney A Moore, Cheri Johnson, Jon E Block
BACKGROUND: Rupture of membranes (ROM) before the onset of uterine contractions, particularly in pregnancies less than 37 weeks gestational age, is a common diagnostic problem in obstetrical practice. Timely detection of ROM is vital to support gestational age-specific interventions to optimize perinatal outcomes and minimize the risk of serious complications such as preterm delivery, fetal distress and maternal/fetal infections. Rapid bedside immunoassay tests designed to detect amniotic fluid proteins in cervicovaginal fluids have emerged as valuable clinical tools to provide timely ROM diagnosis...
April 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28445873/pregnancy-outcomes-in-patients-with-glomerular-disease-attending-a-single-academic-center-in-north-carolina
#2
Michelle M O'Shaughnessy, Meghan A Jobson, Katy Sims, Abigail L Liberty, Patrick H Nachman, William F Pendergraft
BACKGROUND: Contemporary data regarding pregnancy outcomes in US patients with primary glomerular diseases are lacking. We aimed to report fetal and maternal outcomes among women with biopsy-proven primary glomerular disease who received obstetric care at a single large academic US center. METHODS: All women with a biopsy-confirmed primary glomerular disease diagnosis and without end-stage kidney disease who received obstetric care at the University of North Carolina (UNC) Hospitals (1996-2015) were identified using the Glomerular Disease Collaborative Network registry and the UNC Hospitals Perinatal Database...
April 27, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28444651/-mri-based-ratio-of-fetal-lung-to-body-volume-as-new-prognostic-marker-for-chronic-lung-disease-in-patients-with-congenital-diaphragmatic-hernia
#3
Melissa M Winkler, Meike Weis, Claudia Henzler, Christel Weiß, Sven Kehl, Stefan O Schoenberg, Wolfgang Neff, Thomas Schaible
Background Our aim was to evaluate the prognostic value of magnetic resonance imaging (MRI)-based ratio of fetal lung volume (FLV) to fetal body volume (FBV) as a marker for development of chronic lung disease (CLD) in fetuses with congenital diaphragmatic hernia (CDH). Patients and Methods FLV and FBV were measured and the individual FLV/FBV ratio was calculated in 132 fetuses. Diagnosis of CLD was established following prespecified criteria and graded into mild/moderate/severe if present. Logistic regression analysis was used to calculate the probability of postnatal development of CLD in dependence of the FLV/FBV ratio...
March 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28435192/effect-of-peripartum-nutritional-management-on-plasma-profile-of-steroid-hormones-metabolites-and-postpartum-fertility-in-buffaloes
#4
R M Kalasariya, A J Dhami, K K Hadiya, D N Borkhatariya, J A Patel
AIM: The aim of this study was to evaluate the influence of peripartum protein and minerals supplementation on plasma profile of steroid hormones, metabolites, and fertility in rural buffaloes. MATERIAL AND METHODS: A total of 85 advanced pregnant (~8 months) pluriparous buffaloes selected at farmers' doorstep in three tribal villages of Middle Gujarat were randomly divided into two groups, viz., control (n=45) and nutrients treatment (40). The buffaloes of treatment group (n=40), in addition to farmers feeding schedule/control, received daily 1...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28428837/large-is-required-for-normal-astrocyte-migration-and-retinal-vasculature-development
#5
Min Zhou, Herui Wang, Hui Ren, Rui Jiang, Chi Zhang, Xiaohui Wu, Gezhi Xu
BACKGROUND: Persistent fetal vasculature (PFV) is a congenital developmental anomaly of the eye that accounts for about 5% of childhood blindness. The molecular mechanism of PFV remains unclear. As a glycosyltransferase of α-dystroglycan, LARGE mutations have been found in congenital muscular dystrophy patients with brain abnormalities. Spontaneous Large mutant mice displayed similar symptoms of human muscle-eye-brain disorders. However, the detailed roles of Large in ocular vasculature development still need to be uncovered...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28423971/intrauterine-infection-immune-system-and-premature-birth
#6
Fernanda Rodrigues Helmo, Eduardo Arthur Rodovalho Alves, Renata Alves de Andrade Moreira, Viviane Oliveira Severino, Laura Penna Rocha, Maria Luíza Gonçalves Dos Reis Monteiro, Marlene Antônia Dos Reis, Renata Margarida Etchebehere, Juliana Reis Machado, Rosana Rosa Miranda Corrêa
Preterm birth accounts for nearly one million deaths among children under five years of age, and although its etiopathogenesis is not fully elucidated, ascending intrauterine infection and fetal inflammatory response seem to be the main triggers. The intense inflammatory response mediated by IL-1β, TNF-α, PAF, IFN-γ and IL-6, PGE2 and MMP-1 and MMP-9 causes fetal membrane damage and rupture, increased uterine contractions and biochemical and structural changes in the cervix. Furthermore, preterm neonates have deficient innate and adaptive immune responses characterized by reduced levels of IgG, opsonization and phagocytosis, as well as increased activation of Th1 cells in relation to Th2 cells...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28421116/mitochondrial-maturation-in-human-pluripotent-stem-cell-derived-cardiomyocytes
#7
Dao-Fu Dai, Maria Elena Danoviz, Brian Wiczer, Michael A Laflamme, Rong Tian
Human pluripotent stem cells derived cardiomyocytes (PSC-CMs) have been widely used for disease modeling, drug safety screening, and preclinical cell therapy to regenerate myocardium. Most studies have utilized PSC-CM grown in vitro for a relatively short period after differentiation. These PSC-CMs demonstrated structural, electrophysiological, and mechanical features of primitive cardiomyocytes. A few studies have extended in vitro PSC-CM culture time and reported improved maturation of structural and electromechanical properties...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28418339/fetal-nasal-bone-length-as-a-novel-marker-for-prediction-of-adverse-perinatal-outcomes-in-the-first-trimester-of-pregnancy
#8
Mehmet Tunç Canda, Namık Demir, Orçun Sezer
BACKGROUND: Adverse outcomes of pregnancy are a challenging health-care problem. Prediction of adverse pregnancy outcomes is important to prevent the morbidities of the foetus and the mother. AIMS: To study the clinical interest of fetal nasal bone length in predicting adverse pregnancy outcomes in the first trimester of pregnancy. STUDY DESIGN: A population-based retrospective cohort study. METHODS: Data from 868 women with first-trimester fetal nasal bone length and birth records available were enrolled...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28417285/alcohol-and-thiamine-deficiency-trigger-differential-mitochondrial-transition-pore-opening-mediating-cellular-death
#9
REVIEW
Abdoulaye Bâ
Accumulating evidence has shown that binge-type alcohol intake in mothers interferes with thiamine deficiency (TD) to promote the fetal alcohol syndrome (FAS). Developmental alcohol or TD exposures act either synergistically or separately to reproduce FAS features e.g. intrauterine growth retardation and related microcephaly characterized by extensive cellular death induced by one another neurotoxicant. However molecular and cellular mechanisms underlying apoptosis in both alcohol and TD toxicities are unknown...
June 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28413837/familial-exudative-vitreoretinopathy-presentation-as-persistent-fetal-vasculature
#10
Jeffrey Z Kartchner, M Elizabeth Hartnett
PURPOSE: To illustrate a presentation of familial exudative vitreoretinopathy (FEVR) that can be mistaken for unilateral persistent fetal vasculature (PFV) and the importance of wide angle fluorescein angiography in making this distinction. A patient was referred with a unilateral retrolental membrane and retinal detachment from PFV but was found to have FEVR. OBSERVATIONS: A 4 month-old full-term infant was referred with the diagnosis of PFV based on findings of a dense retrolental membrane and microphthalmia in the left eye...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/28412676/investigation-of-sub-health-status-of-neonates-in-heping-street-region-beijing-and-analysis-on-related-risk-factors
#11
Chen Jie, Shi Mai, Li Qiuju, Ye Fang, Liu Fang, Fan Qinying, Zhang Yong, Wang Lin
To investigate sub-health status of neonates in Heping Street Region and related risk factors. Then, 7436 maternal women admitted to hospital in Heping Street Region, Beijing were enrolled from October 2013 to September 2015, including 293 women, who gave birth to sub-health neonates. Questionnaire survey was conducted to collect maternal age, education degree, experiences and income, occupation, life habit, condition in pregnancy, condition in perinatal period, adverse reaction in pregnancy, etc. Finally, 281 effective questionnaires were regained with effective regain rate of 95...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28412674/analysis-of-relevant-risk-factors-for-intrauterine-death-of-fetuses-in-the-third-trimester-of-pregnancy
#12
Yang Qiong, Yuan Yichong
Our study aimed to explore the relevant risk factors for intrauterine death of fetuses in the third trimester of pregnancy via a retrospective analysis. Then, 98 pregnant women with intrauterine death of fetuses in the third trimester of pregnancy were enrolled, who had undergone the induced labor of dead fetuses in our hospital from January, 2013 to January, 2015. By taking their disease conditions into considerations, methods of induced labor as softening of cervix with dinoprostone suppositories and amniotic infusion of ethacridine or oxytocin were performed, and the timely cesarean section for termination of pregnancy was performed...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28409530/digital-stretching-of-cervix-in-the-active-phase-of-labour-to-shorten-its-duration-a-randomised-control-trial
#13
Deepti Pinto Rosario, Anuja Abraham, Swati Rathore, Santosh Joseph Benjamin, Visalakshi Jeyaseelan, Jiji Elizabeth Mathews
An assessment of the efficacy and satisfaction of women in active labour having digital cervical stretching compared to women who did not have this intervention. Ours was a randomised controlled trial at a tertiary centre in India. Low-risk women at term with vertex presentation in active labour with ruptured membranes and cervical dilation of 4-6 cm were included. Stretching to delivery interval was 247.5 ± 158.2 min in the intervention group and 265.5 ± 158.4 in the control group. The mode of delivery, incidence of cervical tear, and maternal, fetal and neonatal complications were similar in both groups...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28407219/multiple-micronutrient-supplementation-for-women-during-pregnancy
#14
REVIEW
Batool A Haider, Zulfiqar A Bhutta
BACKGROUND: Multiple-micronutrient (MMN) deficiencies often coexist among women of reproductive age in low- to middle-income countries. They are exacerbated in pregnancy due to the increased demands, leading to potentially adverse effects on the mother and developing fetus. Though supplementation with MMNs has been recommended earlier because of the evidence of impact on pregnancy outcomes, a consensus is yet to be reached regarding the replacement of iron and folic acid supplementation with MMNs...
April 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28403891/foley-catheter-for-cervical-priming-in-induction-of-labour-at-university-obstetrics-unit-colombo-sri-lanka-a-clinical-audit-with-a-patient-satisfaction-survey
#15
M Patabendige, A Jayawardane
BACKGROUND: Intracervical insertion of a Foley catheter (FC) has shown to be a safe, effective and relatively feasible mechanical method of cervical priming in induction of labour (IOL). We evaluated indications, effectiveness, patient acceptability and outcomes of FC use in IOL adhering to the ward protocol in our unit. METHODS: A clinical audit with a patient satisfaction survey conducted between July and September 2013 in University Obstetric Unit, Colombo, Sri Lanka...
April 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28395914/structurally-and-functionally-characterized-in-vitro-model-of-rabbit-vocal-fold-epithelium
#16
Masanobu Mizuta, Takashi Kurita, Emily E Kimball, Bernard Rousseau
In this paper, we describe a method for primary culture of a well differentiated electrically tight rabbit vocal fold epithelial cell multilayer and the measurement of transepithelial electrical resistance (TEER) for the evaluation of epithelial barrier function in vitro. Rabbit larynges were harvested and enzymatically treated to isolate vocal fold epithelial cells and to establish primary culture. Vocal fold epithelial cells were co-cultured with mitomycin C-treated feeder cells on collagen-coated plates...
March 24, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28392580/pregnancies-in-women-aged-45-years-and-older-a-10-year-retrospective-analysis-in-berlin
#17
Rosa Rendtorff, Larry Hinkson, Verena Kiver, Lisa Antonia Dröge, Wolfgang Henrich
Introduction Improved fertility treatment options and a change in the socio-cultural concept of family planning, especially in industrialized regions, has led to an increasing number of births by women of advanced maternal age, which is associated with a higher rate of complications. The aim of this study was to analyze pregnancy outcomes in women aged ≥ 45 years in an inner-city German hospital and to compare these results to those of a younger cohort. Materials and Methods Over a 10-year period from January 2004 to May 2015, the pregnancy outcomes of all 186 women aged ≥ 45 years who delivered in our hospital were compared in a 1 : 1 ratio to those of a cohort of 29-year old women...
March 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28391733/antenatal-magnesium-sulfate-for-both-tocolysis-and-fetal-neuroprotection-in-premature-rupture-of-the-membranes-before-32-weeks-gestation
#18
Eun Jung Jung, Jung Mi Byun, Young Nam Kim, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Jong Beom Shin, Dae Hoon Jeong
OBJECTIVE: We aimed to assess the impact of antenatal MgSO4 therapy given to women with PPROM before 32 weeks' gestation on latency, maternal outcomes, perinatal outcomes, and neurodevelopmental outcomes. METHODS: We undertook a retrospective cohort observational study of 184 singleton pregnancies complicated by PPROM at 23(°)-31(6) weeks who were hospitalized and received magnesium therapy for tocolysis (MgSO4 group) or did not received tocolytic therapy (no MgSO4 group) between 2005 and 2013...
April 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28388825/observational-study-of-associations-between-gestational-weight-gain-and-perinatal-outcomes-in-dichorionic-twin-pregnancies
#19
Katarzyna Kosinska-Kaczynska, Iwona Szymusik, Bartosz Kaczynski, Miroslaw Wielgos
OBJECTIVE: To evaluate relationships between gestational weight gain (GWG) and adverse events during pregnancy among patients of normal weight with twin pregnancies. METHODS: The present observational study included patients with dichorionic twin pregnancies with a pre-gravid body mass index of 18.5-24.99 kg/m(2) who underwent delivery at no earlier than 22 weeks of pregnancy between January 1, 2007, and June 30, 2016, at the Medical University of Warsaw, Warsaw, Poland...
April 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28386088/induction-of-pro-inflammatory-genes-by-serum-amyloid-a1-in-human-amnion-fibroblasts
#20
Wenjiao Li, Wangsheng Wang, Rujuan Zuo, Chao Liu, Qun Shu, Hao Ying, Kang Sun
Serum amyloid A1 (SAA1) is an acute response protein, which is mainly produced by the liver, during infection. However, it remains unknown whether SAA1 can be produced in human fetal membranes where it is able to elicit events pertinent to labor initiation. We demonstrated that SAA1 was expressed in the fibroblasts and epithelium of the amnion and the trophoblasts of the chorion. Further study in human amnion fibroblasts showed that SAA1 production was augmented by interleukin-1β (IL-1β) and cortisol alone and synergistically, and SAA1 in turn induced the expression of IL-1β, interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and PGE2 production...
April 6, 2017: Scientific Reports
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