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hpv human papillomavirus

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https://www.readbyqxmd.com/read/28943519/smoking-human-papillomavirus-infection-and-p53-mutation-as-risk-factors-in-oropharyngeal-cancer-a-case-control-study
#1
P Ks Chan, J Sy Chor, A C Vlantis, T L Chow, S C Fung, C H Lau, F Yh Ng, C S Wong
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28943518/human-papillomavirus-infection-and-squamous-cell-carcinoma-in-hong-kong-a-case-control-study
#2
P Ks Chan, K F To, S H Tsang, C H Lau, W H Kwong, Y Hy Chan
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28943220/who-s-not-protected-in-the-herd-factors-associated-with-vaccine-type-hpv-in-unvaccinated-women
#3
C Smith, L Ding, P M Gorbach, E L Franco, J A Kahn
STUDY OBJECTIVE: Evidence suggests that vaccine-type human papillomavirus (HPV) prevalence may decrease in unvaccinated women after HPV vaccine introduction, indicating herd protection. The aim of this study was to determine factors associated with vaccine-type HPV (i.e. absence of herd protection) after vaccine introduction. DESIGN: We conducted three cross-sectional studies from 2006-2014 (n=1180): wave 1 (2006-2007), wave 2 (2009-2010), and wave 3 (2013-2014)...
September 21, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28941263/epidermodysplasia-verruciformis-three-case-reports-and-a-brief-review
#4
Sharma Shruti, Fouzia Siraj, Avninder Singh, V Ramesh
Epidermodyplasia verruciformis (EV) is a rare heritable disease that is characterized by an increased susceptibility to infection with specific human papillomavirus (HPV) types due to a defect in cell-mediated immune response to HPV infection. Widespread infection with HPV is responsible for the development of wart-like lesions and pityriasis versicolor-like spots. These individuals have a lifelong risk of developing cutaneous malignancies, especially Bowen's disease and squamous cell carcinoma, mainly in sun-exposed parts...
September 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28941262/comparison-of-the-risk-factors-and-hpv-types-in-males-with-anogenital-warts-with-and-without-involvement-of-the-urethral-meatus-in-western-iran
#5
Ali Ebrahimi, Mahmood Reza Moradi, Mansour Rezaei, Hossein Kavoussi, Hamid Madani, Kiarash Mohammadamini, Reza Kavoussi
BACKGROUND: Human papillomavirus (HPV)-induced lesions rarely develop in the urethral meatus (UM); however, their eradication can be problematic. METHODS: A total of 22 patients with anogenital warts (AGWs) in the UM region and 22 patients with AGWs located at other anatomical sites were included in this cross-sectional study. The presence of human papillomavirus (HPV) types in biopsy samples was determined using the HPV Easy typing kit (GenID GmbH, Germany). RESULTS: Although the patients in the AGW group with involvement of the UM had a higher incidence of reported multiple sexual partners (63...
September 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28940446/the-pd-1-and-pd-l1-pathway-in-recurrent-respiratory-papillomatosis
#6
Julie Ahn, Justin A Bishop, Richard B S Roden, Clint T Allen, Simon R A Best
OBJECTIVES/HYPOTHESIS: Generation of an immunosuppressive microenvironment may enable a persistent human papillomavirus infection in the setting of an otherwise normal immune system. We hypothesized that expression of the T-lymphocyte co-inhibitory receptor programmed death 1 (PD-1) and its ligand PD-L1 would be increased in the recurrent respiratory papillomatosis (RRP) microenvironment compared to normal controls. STUDY DESIGN: Case-control study. METHODS: Formalin-fixed paraffin-embedded respiratory papilloma and normal controls were obtained under institutional review board approval, stained for CD4, CD8, FoxP3, and PD-1, and scored by automated cell count...
September 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28939477/a-novel-candidate-ms2-phage-vlp-vaccine-displaying-a-tandem-hpv-l2-peptide-offers-similar-protection-in-mice-to-gardasil-9
#7
Lukai Zhai, Julianne Peabody, Yuk-Ying Susana Pang, John Schiller, Bryce Chackerian, Ebenezer Tumban
Human papillomaviruses (HPVs) cause approximately 5% of cancer cases worldwide. Fortunately, three prophylactic vaccines have been approved to protect against HPV infections. Gardasil-9, the most recent HPV vaccine, is predicted to offer protection against the HPV types that cause ∼90% of cervical cancer, 86% of HPV-associated penile cancers, and ∼93% of HPV-associated head & neck cancers. As an alternative to Gardasil-9, we developed and tested a novel candidate vaccine targeting conserved epitopes in the HPV minor capsid protein, L2...
September 19, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28939080/prevalence-of-high-risk-human-papillomavirus-infection-and-cancer-gene-mutations-in-nonmalignant-tonsils
#8
Taru Ilmarinen, Pauliina Munne, Jaana Hagström, Caj Haglund, Eeva Auvinen, Elina I Virtanen, Annick Haesevoets, Ernst J M Speel, Leena-Maija Aaltonen
OBJECTIVES: To analyze the prevalence of high-risk HPV (human papillomavirus) and genetic alterations in nonmalignant tonsils. METHODS: We collected benign fresh tonsillar tissue specimens from 477 patients undergoing tonsillectomy because of chronic tonsillitis or tonsillar hypertrophy in 2012 (Group A, n=237) and in 2015 (Group B, n=240). Luminex xMAP technique served to detect E6/E7 DNA from 16 different high-risk HPV types. Tonsillar DNA and peripheral blood leukocyte DNA from the infected individuals were analyzed using Nimblegen SeqCap EZ Comprehensive Cancer Design panel...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28939071/intraindividual-homogeneity-of-18-f-fdg-pet-ct-parameters-in-hpv-positive-opscc
#9
Shachi Jenny Sharma, Claus Wittekindt, Jennifer Knuth, Dagmar Steiner, Nora Wuerdemann, Maren Laur, Tobias Kroll, Steffen Wagner, Jens Peter Klussmann
OBJECTIVES: (18)F-FDG PET/CT is widely used in clinical oncology. Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) represents an emerging disease that differs from HPV-negative OPSCC in clinical behavior and tumour biology. In these tumours, HPV-oncogenes might lead to distinct alterations in metabolic pathways. Therefore, we compared metabolic parameters using (18)F-FDG PET/CT in HPV-positive and HPV-negative OPSCC in relation to histopathological findings...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28939068/appraisal-of-the-ajcc-8th-edition-pathologic-staging-modifications-for-hpv-positive-oropharyngeal-cancer-a-study-of-the-national-cancer-data-base
#10
Kevin Y Zhan, Antoine Eskander, Stephen Y Kang, Matthew O Old, Enver Ozer, Amit A Agrawal, Ricardo L Carrau, James W Rocco, Theodoros N Teknos
BACKGROUND: The American Joint Commission on Cancer (AJCC) recently created new staging for human papillomavirus associated oropharyngeal cancer (HPV+ OPSCC) for its 8th edition. These proposals have not yet been validated in a national registry. METHODS: Review of National Cancer Database (NCDB) for surgically-treated HPV+ OPSCC for years 2010-2014 to validate the new staging system using the Kaplan Meier method to explore survival outcomes. RESULTS: 3745 cases were analyzed...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28938686/incidence-and-clearance-of-oral-human-papillomavirus-infection-a-population-based-cohort-study-in-rural-china
#11
Chaoting Zhang, Fangfang Liu, Yaqi Pan, Qiuju Deng, Xiang Li, Zhonghu He, Mengfei Liu, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke
The natural history of oral human papillomavirus (HPV) infection which is linked with the increased incidence of oropharyngeal squamous cell cancer (OPSCC) has been incompletely studied. Oral swab specimens and questionnaire data were obtained bi-annually for up to 6 visits from 4314 healthy adults aged 25-69 in rural Anyang, China. HPV infection status was evaluated with PCR-based sequencing. Participants with at least two consecutive valid HPV results within the study period were included in the incidence and clearance analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938638/prognostic-modeling-of-oral-cancer-by-gene-profiles-and-clinicopathological-co-variables
#12
Steven W Mes, Dennis Te Beest, Tito Poli, Silvia Rossi, Kathrin Scheckenbach, Wessel N van Wieringen, Arjen Brink, Nicoletta Bertani, Davide Lanfranco, Enrico M Silini, Paul J van Diest, Elisabeth Bloemena, C René Leemans, Mark A van de Wiel, Ruud H Brakenhoff
Accurate staging and outcome prediction is a major problem in clinical management of oral cancer patients, hampering high precision treatment and adjuvant therapy planning. Here, we have built and validated multivariable models that integrate gene signatures with clinical and pathological variables to improve staging and survival prediction of patients with oral squamous cell carcinoma (OSCC). Gene expression profiles from 249 human papillomavirus (HPV)-negative OSCCs were explored to identify a 22-gene lymph node metastasis signature (LNMsig) and a 40-gene overall survival signature (OSsig)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938139/hpv-literacy-and-its-link-to-initiation-and-completion-of-hpv-vaccine-among-young-adults%C3%A2-in%C3%A2-minnesota
#13
H Y Lee, J Lee, C Henning-Smith, J Choi
OBJECTIVES: This study identifies whether, and how, human papillomavirus (HPV) literacy and predisposing, enabling, and need factors are associated with HPV vaccine initiation and completion among young adults in Minnesota. STUDY DESIGN: Cross-sectional survey design. METHODS: Using a sample of 170 young adults (aged 18-26 years), we used logistic regression models to identify factors associated with HPV vaccination initiation and completion, including HPV literacy, adjusting for relevant predisposing, enabling, and need factors...
September 19, 2017: Public Health
https://www.readbyqxmd.com/read/28937589/viral-cellular-dna-junctions-as-molecular-markers-for-assessing-intra-tumor-heterogeneity-in-cervical-cancer-and-for-the-detection-of-circulating-tumor-dna
#14
Katrin Carow, Mandy Gölitz, Maria Wolf, Norman Häfner, Lars Jansen, Heike Hoyer, Elisabeth Schwarz, Ingo B Runnebaum, Matthias Dürst
The development of cervical cancer is frequently accompanied by the integration of human papillomaviruses (HPV) DNA into the host genome. Viral-cellular junction sequences, which arise in consequence, are highly tumor specific. By using these fragments as markers for tumor cell origin, we examined cervical cancer clonality in the context of intra-tumor heterogeneity. Moreover, we assessed the potential of these fragments as molecular tumor markers and analyzed their suitability for the detection of circulating tumor DNA in sera of cervical cancer patients...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937367/associations-between-epidermal-growth-factor-receptor-and-topoisomerase-ii-alpha-gene-copy-number-variations-human-papillomavirus-positivity-and-cytologic-analysis-in-cervical-cell-lesions
#15
Işın Kaya, Oya Nermin Sivrikoz, Özdal Etlik, Abdülkadir Gök
BACKGROUND: Cervical cancer is the second most common gynecologic cancer worldwide. Human papillomavirus (HPV) infection is a leading etiological factor in cervical carcinoma.The aim of this study was to compare HPV positivity, EGFR and TOP2A gene copy number variations and cervical cytologic findings. MATERIALS AND METHODS: The study group comprised 100 female volunteers between 21-64 years old. Cytologic analysis was performed using the liquid-based cytology technique...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936976/progress-in-studies-of-the-mechanisms-and-clinical-diagnosis-of-cervical-carcinoma-associated-with-genomic-integration-of-high-risk-human-papillomavirus-dna
#16
Sha-Sha Huang, Deng-Zai Hao, Yan Zhang, Hou-Ming Liu, Wan-Shui Shan
High-risk human papillomavirus (hrHPV) has been identified as a key factor in the development of cervical cancer. Integration of viral DNA into the host genome has been postulated as an important etiological event during cervical carcinogenesis. High-risk HPV DNA integration frequently results in either the deletion or interruption of the large fragment of E1 and E2 region and the overexpression of oncogenes E6 and E7 in the viral genome, and the activation of oncogenes and the inactivation of tumor suppressors in host genome...
September 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28935469/risk-of-guillain-barr%C3%A3-syndrome-following-quadrivalent-human-papillomavirus-vaccine-in-the-vaccine-safety-datalink
#17
Julianne Gee, Lakshmi Sukumaran, Eric Weintraub
OBJECTIVE: Describe the Vaccine Safety Datalink's (VSD) Guillain Barré Syndrome (GBS) surveillance following quadrivalent HPV vaccine (4vHPV) from 2006 through 2015. METHODS: Among 4vHPV vaccinated persons aged 9-26, ICD-9 coded GBS was identified in VSD's electronic data. Medical records were reviewed and adjudicated to confirm GBS. We calculated incidence rates of confirmed GBS within 1-42days following 4vHPV with a one-sided 95% confidence interval. RESULTS: Following 2,773,185 4vHPV doses, we confirmed 1 case of GBS in a male and no cases among females...
September 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28934937/mir-9-mir-21-and-mir-155-as-potential-biomarkers-for-hpv-positive-and-negative-cervical-cancer
#18
Sunyoung Park, Kiyoon Eom, Jungho Kim, Hyeeun Bang, Hye-Young Wang, Sungwoo Ahn, Geehyuk Kim, Hyoungsoon Jang, Sunghyun Kim, Dongsup Lee, Kwang Hwa Park, Hyeyoung Lee
BACKGROUND: Cervical cancer is the second leading cause of death among female patients with cancer in the world. High risk human papillomavirus has causal roles in cervical cancer initiation and progression by deregulating several cellular processes. However, HPV infection is not sufficient for cervical carcinoma development. Therefore, other genetic and epigenetic factors may be involved in this complex disease, and the identification of which may lead to better diagnosis and treatment...
September 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28934441/2-dose-schedule-of-as04-adjuvanted-human-papillomavirus-types-16-18-vaccine
#19
Dimitri Poddighe
No abstract text is available yet for this article.
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934154/why-human-papillomaviruses-activate-the-dna-damage-response-ddr-and-how-cellular-and-viral-replication-persists-in-the-presence-of-ddr-signaling
#20
REVIEW
Molly L Bristol, Dipon Das, Iain M Morgan
Human papillomaviruses (HPV) require the activation of the DNA damage response (DDR) in order to undergo a successful life cycle. This activation presents a challenge for the virus and the infected cell: how does viral and host replication proceed in the presence of a DDR that ordinarily arrests replication; and how do HPV16 infected cells retain the ability to proliferate in the presence of a DDR that ordinarily arrests the cell cycle? This raises a further question: why do HPV activate the DDR? The answers to these questions are only partially understood; a full understanding could identify novel therapeutic strategies to target HPV cancers...
September 21, 2017: Viruses
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