Michael R Arul, Ibtihal Alahmadi, Daylin Gamiotea Turro, Aditya Ruikar, Sama Abdulmalik, Justin T Williams, Basavaraju G Sanganahalli, Bruce T Liang, Rajkumar Verma, Sangamesh G Kumbar
Ischemic stroke causes acute CNS injury and long-term disability, with limited treatment options such as surgical clot removal or clot-busting drugs. Neuroprotective therapies are needed to protect vulnerable brain regions. The purinergic receptor P2X4 is activated during stroke and exacerbates post-stroke damage. The chemical compound 5-(3-Bromophenyl)-1,3-dihydro-2 H -Benzofuro[3,2- e ]-1,4-diazepin-2-one (5BDBD) inhibits P2X4 and has shown neuroprotective effects in rodents. However, it is difficult to formulate for systemic delivery to the CNS...
October 30, 2023: Biomaterials Science