Valerie J Brock, Niels Christian Lory, Franziska Möckl, Melina Birus, Tobias Stähler, Lena-Marie Woelk, Michelle Jaeckstein, Joerg Heeren, Friedrich Koch-Nolte, Björn Rissiek, Hans-Willi Mittrücker, Andreas H Guse, René Werner, Björn-Philipp Diercks
CD8+ T cells are a crucial part of the adaptive immune system, responsible for combating intracellular pathogens and tumor cells. The initial activation of T cells involves the formation of highly dynamic Ca2+ microdomains. Recently, purinergic signaling was shown to be involved in the formation of the initial Ca2+ microdomains in CD4+ T cells. In this study, the role of purinergic cation channels, particularly P2X4 and P2X7, in CD8+ T cell signaling from initial events to downstream responses was investigated, focusing on various aspects of T cell activation, including Ca2+ microdomains, global Ca2+ responses, NFAT-1 translocation, cytokine expression, and proliferation...
2024: Frontiers in Immunology