Francesca I Cendali, Travis Nemkov, Christina Lisk, Ian S Lacroix, Seyed-Mehdi Nouraie, Yingze Zhang, Victor R Gordeuk, Paul W Buehler, David Irwin, Angelo D'Alessandro
Introduction: Exercise intolerance is a common clinical manifestation in patients with sickle cell disease (SCD), though the mechanisms are incompletely understood. Methods: Here we leverage a murine mouse model of sickle cell disease, the Berkeley mouse, to characterize response to exercise via determination of critical speed (CS), a functional measurement of mouse running speed upon exerting to exhaustion. Results: Upon observing a wide distribution in critical speed phenotypes, we systematically determined metabolic aberrations in plasma and organs-including heart, kidney, liver, lung, and spleen-from mice ranked based on critical speed performances (top vs...
2023: Frontiers in Physiology