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https://www.readbyqxmd.com/read/28343364/comparison-between-the-effect-of-6-weeks-of-morning-or-evening-aerobic-exercise-on-appetite-and-anthropometric-indices-a-randomized-controlled-trial
#1
Z Alizadeh, S Younespour, M Rajabian Tabesh, S Haghravan
Several studies have shown that exercise is directly related to creating negative energy balance and changes in appetite. However, few studies have examined the effect of exercise time during the day on these factors. The aim of the present study was to demonstrate the effect of 6 weeks of morning and evening aerobic exercise on appetite and anthropometric indices. A total of 48 overweight females were recruited to this clinical trial. By the time of exercise, they were divided into two groups (morning or evening) and performed 6 weeks of exercise with a target heart rate on the ventilatory threshold...
March 26, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28343352/the-role-of-hypofractionated-radiotherapy-in-prostate-cancer
#2
REVIEW
Linus C Benjamin, Alison C Tree, David P Dearnaley
PURPOSE OF REVIEW: It is now accepted that prostate cancer has a low alpha/beta ratio, establishing a strong basis for hypofractionation of prostate radiotherapy. This review focuses on the rationale for hypofractionation and presents the evidence base for establishing moderate hypofractionation for localised disease as the new standard of care. The emerging evidence for extreme hypofractionation in managing localized and oligometastatic prostate cancer is reviewed. RECENT FINDINGS: The 5-year efficacy and toxicity outcomes from four phase III studies have been published within the last 12 months...
April 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28343328/skeletal-development-of-the-hand-and-wrist-digital-bone-age-companion-a-suitable-alternative-to-the-greulich-and-pyle-atlas-for-bone-age-assessment
#3
Paul M Bunch, Talissa A Altes, Joan McIlhenny, James Patrie, Cree M Gaskin
PURPOSE: To assess reader performance and subjective workflow experience when reporting bone age studies with a digital bone age reference as compared to the Greulich and Pyle atlas (G&P). We hypothesized that pediatric radiologists would achieve equivalent results with each method while digital workflow would improve speed, experience, and reporting quality. MATERIALS AND METHODS: IRB approval was obtained for this HIPAA-compliant study. Two pediatric radiologists performed research interpretations of bone age studies randomized to either the digital (Digital Bone Age Companion, Oxford University Press) or G&P method, generating reports to mimic clinical workflow...
March 25, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28343299/the-role-of-line-1-methylation-in-predicting-survival-among-colorectal-cancer-patients-a-meta-analysis
#4
Ding Ye, Danjie Jiang, Yingjun Li, Mingjuan Jin, Kun Chen
BACKGROUND: The prognostic value of long interspersed nucleotide element-1 (LINE-1) methylation in patients with colorectal cancer (CRC) remains uncertain. We have therefore performed a meta-analysis to elucidate this issue. METHODS: The PubMed and Web of Science databases were searched for studies published up to 30 June 2016 which reported on an association between LINE-1 methylation and overall survival (OS), disease-free survival (DFS), or cancer-specific survival (CSS) among CRC patients...
March 25, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28343270/magnetic-field-discrimination-learning-and-memory-in-the-yellow-stingray-urobatis-jamaicensis
#5
Kyle C Newton, Stephen M Kajiura
Elasmobranch fishes (sharks, skates, and rays) have been hypothesized to use the geomagnetic field as a cue for orienting and navigating across a wide range of spatial scales. Magnetoreception has been demonstrated in many invertebrate and vertebrate taxa, including elasmobranchs, but this sensory modality and the cognitive abilities of cartilaginous fishes are poorly studied. Wild caught yellow stingrays, Urobatis jamaicensis (N = 8), underwent conditioning to associate a magnetic stimulus with a food reward in order to elicit foraging behaviors...
March 25, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28343265/effect-of-10-cerium-chloride-on-artificial-caries-lesions-of-human-enamel-evaluated-using-quantitative-light-induced-fluorescence-an-in-vitro-study
#6
R Jaisingh, R Shanbhog, B Nandlal, M Thippeswamy
AIM: To evaluate the effect of 10% cerium chloride intervention on pre-demineralised human enamel subjected to cycles of de- and remineralisation. METHODS: This was an in vitro, comparative type study of 60 human enamel samples that were randomly divided into control and test groups. The samples were then subjected to a cycle of demineralisation followed by intervention with respective treatment solutions (control group: placebo solution; test: 10% cerium chloride) for 30 s under constant agitation and then to a 2nd cycle of demineralisation followed by remineralisation using artificial saliva...
March 25, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28343246/sex-differences-and-predictors-of-changes-in-body-weight-and-noncommunicable-diseases-in-a-random-newly-arrived-group-of-refugees-followed-for-two-years
#7
K-L Catherine Jen, Hikmet Jamil, Kequan Zhou, Karen Breejen, Bengt B Arnet
We have reported that none of the psychological/mental variables examined predicted the increase in BMI and non-communicable diseases (NCDs) in Iraqi refugees after 1 year resettlement in Michigan. We continuously followed the same cohort of refugees for 2 years (Y2 FU) to further determine the gender difference in predicting of increased BMI and NCDs. Only 20% of the BMI variability could be accounted for by the factors examined. Number of dependent children and depression were positively and stress negatively associated with BMI in male refugees but not in females...
March 25, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28343235/transcription-dependent-radial-distribution-of-tcf7l2-regulated-genes-in-chromosome-territories
#8
Keyvan Torabi, Darawalee Wangsa, Immaculada Ponsa, Markus Brown, Anna Bosch, Maria Vila-Casadesús, Tatiana S Karpova, Maria Calvo, Antoni Castells, Rosa Miró, Thomas Ried, Jordi Camps
Human chromosomes occupy distinct territories in the interphase nucleus. Such chromosome territories (CTs) are positioned according to gene density. Gene-rich CTs are generally located in the center of the nucleus, while gene-poor CTs are positioned more towards the nuclear periphery. However, the association between gene expression levels and the radial positioning of genes within the CT is still under debate. In the present study, we performed three-dimensional fluorescence in situ hybridization experiments in the colorectal cancer cell lines DLD-1 and LoVo using whole chromosome painting probes for chromosomes 8 and 11 and BAC clones targeting four genes with different expression levels assessed by gene expression arrays and RT-PCR...
March 25, 2017: Chromosoma
https://www.readbyqxmd.com/read/28343225/clinical-trial-of-vadadustat-in-patients-with-anemia-secondary-to-stage-3-or-4-chronic-kidney-disease
#9
Edouard R Martin, Mark T Smith, Bradley J Maroni, Qing C Zuraw, Emil M deGoma
BACKGROUND: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD) inhibitor that is being investigated for the treatment of anemia secondary to CKD. METHODS: A phase 2a, multicenter, randomized, double-blind, placebo-controlled, dose-ranging trial (NCT01381094) was undertaken in adults with anemia secondary to CKD stage 3 or 4...
March 25, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28343218/effect-of-l-carnitine-supplementation-on-reverse-remodeling-in-patients-with-ischemic-heart-disease-undergoing-coronary-artery-bypass-grafting-a-randomized-placebo-controlled-trial
#10
Sheila da Silva Guimarães, Wanise de Souza Cruz, Licinio da Silva, Gabrielle Maciel, Ana Beatriz Huguenin, Monicque de Carvalho, Bárbara Costa, Geisiane da Silva, Carlos da Costa, João Alvaro D'Ippolito, Alexandre Colafranceschi, Fernanda Scalco, Gilson Boaventura
During cardiac failure, cardiomyocytes have difficulty in using the substrates to produce energy. L-carnitine is a necessary nutrient for the transport of fatty acids that are required for generating energy. Coronary artery graft surgery reduces the plasma levels of L-carnitine and increases the oxidative stress. This study demonstrates the effect of L-carnitine supplementation on the reverse remodeling of patients undergoing coronary artery bypass graft. Patients with ischemic heart failure who underwent coronary graft surgery were randomized to group A - supplemented with L-carnitine or group B controls...
March 25, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28343108/the-effects-of-modified-versus-unmodified-wheat-gluten-administration-in-patients-with-celiac-disease
#11
Mariacatia Marino, Rossella Casale, Raffaele Borghini, Sara Di Nardi, Giuseppe Donato, Antonio Angeloni, Salvatore Moscaritolo, Lorenza Grasso, Giuseppe Mazzarella, Marco Di Tola, Mauro Rossi, Antonio Picarelli
Celiac disease (CD) treatment requires a gluten-free diet (GFD), although alternative approaches have been proposed. Modification of gliadin peptides using microbial transglutaminase (mTG) inhibits their ability to induce immune response in vitro. Our aim was to evaluate the safety of mTG-modified wheat flour ingestion in CD patients. Twenty-one CD patients in remission were randomized to receive mTG-modified (n=11) or unmodified (n=10) wheat flour rusks, in double-blind fashion. Monthly, patients completed a symptom questionnaire...
March 23, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28343073/breviscapine-confers-a-neuroprotective-efficacy-against-transient-focal-cerebral-ischemia-by-attenuating-neuronal-and-astrocytic-autophagy-in-the-penumbra
#12
Zhang Pengyue, Guo Tao, He Hongyun, Yang Liqiang, Deng Yihao
Breviscapine is a flavonoid derived from a traditional Chinese herb Erigerin breviscapus (Vant.) Hand-Mazz, and has been extensively used in clinical treatment for cerebral stroke in China, but the underlying pharmacological mechanisms are still unclear. In present study, we investigated whether breviscapine could confer a neuroprotection against cerebral ischemia injury by targeting autophagy mechanisms. A cerebral stroke model in Sprague-Dawley rats was prepared by middle cerebral artery occlusion (MCAO), rats were then randomly divided into 5 groups: MCAO+Bre group, rats were treated with breviscapine; MCAO+Tat-Beclin-1 group, animals were administrated with specific autophagy inducer Tat-Beclin-1; MCAO+Bre+Tat-Beclin-1 group, rats were treated with both breviscapine and Tat-Beclin-1, MCAO+saline group, rats received the same volume of physiological saline, and Sham surgery group...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28343071/analgesia-effect-of-baicalein-against-ntg-induced-migraine-in-rats
#13
Xiao-Fan Zhang, Wen-Jun Zhang, Cui-Lan Dong, Wan-Li Hu, Yu-Yao Sun, Yarigui Bao, Chun-Feng Zhang, Chang-Run Guo, Chong-Zhi Wang, Chun-Su Yuan
BACKGROUND: Migraine is a complex nervous system disease characterized by typical throbbing and unilateral headache, which causes severe healthy and social issues worldwide. The purpose of this study was to investigate the effect of baicalein (BAI) on the treatment of migraine. MATERIAL AND METHODS: Twenty-four rats were randomly divided equally into four groups, including a blank group, model group, positive group (ibuprofen tablets 82mg/kg), and BAI group (60mg/kg)...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28343051/tolerability-of-cariprazine-in-the-treatment-of-acute-bipolar-i-mania-a-pooled-post-hoc-analysis-of-3-phase-ii-iii-studies
#14
Willie Earley, Suresh Durgam, Kaifeng Lu, Marc Debelle, István Laszlovszky, Eduard Vieta, Lakshmi N Yatham
BACKGROUND: Atypical antipsychotics have broad-spectrum efficacy against core symptoms of acute mania/mixed states in bipolar disorder; however, they are associated with clinically significant adverse effects (AEs). METHODS: This post hoc analysis evaluated the safety and tolerability of the atypical antipsychotic cariprazine in the treatment of adult patients with acute manic/mixed episodes of bipolar I disorder. Data were taken from three 3-week randomized, double-blind, placebo-controlled, flexible-dose trials of cariprazine 3-12mg/d...
March 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28343023/classification-of-footwear-outsole-patterns-using-fourier-transform-and-local-interest-points
#15
Nicole Richetelli, Mackenzie C Lee, Carleen A Lasky, Madison E Gump, Jacqueline A Speir
Successful classification of questioned footwear has tremendous evidentiary value; the result can minimize the potential suspect pool and link a suspect to a victim, a crime scene, or even multiple crime scenes to each other. With this in mind, several different automated and semi-automated classification models have been applied to the forensic footwear recognition problem, with superior performance commonly associated with two different approaches: correlation of image power (magnitude) or phase, and the use of local interest points transformed using the Scale Invariant Feature Transform (SIFT) and compared using Random Sample Consensus (RANSAC)...
March 4, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28342990/telephone-adapted-mindfulness-based-stress-reduction-tmbsr-for-patients-awaiting-kidney-transplantation
#16
Cynthia R Gross, Maryanne Reilly-Spong, Taehwan Park, Ruizhi Zhao, Olga V Gurvich, Hassan N Ibrahim
BACKGROUND: Patients with progressive kidney disease experience increasing physiologic and psychosocial stressors and declining health-related quality of life (HRQOL). METHODS: We conducted a randomized, active-controlled, open-label trial to test whether a Mindfulness-based Stress Reduction (MBSR) program delivered in a novel workshop-teleconference format would reduce symptoms and improve HRQOL in patients awaiting kidney transplantation. Sixty-three transplant candidates were randomized to one of two arms: i) telephone-adapted MBSR (tMBSR, an 8-week program of meditation and yoga); or ii) a telephone-based support group (tSupport)...
March 22, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28342988/an-anti-inflammatory-dietary-intervention-to-reduce-breast-cancer-recurrence-risk-study-design-and-baseline-data
#17
Amelie G Ramirez, Dorothy Long Parma, Edgar Muñoz, Kristin D Mendoza, Crystel Harb, Alan E C Holden, Michael Wargovich
U.S. breast cancer survivors (BCSs) are expected to increase to 4 million in the next 5-10years. Cancer recurrence risk is highest among obese survivors. Inflammatory (Pro-I) biomarkers including C-reactive protein (CRP), Interleukins -3, -6, and -8 (IL-3, IL-6, IL-8), and Tumor Necrosis Factor (TNF)-α have been associated with cancer recurrence risk. Nutritional interventions aimed at reducing inflammation (INF) may contribute to reduced cancer recurrence risk, but studies have been limited to animal models...
March 22, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28342967/the-effects-of-omega-3-fatty-acids-and-vitamin-e-co-supplementation-on-clinical-and-metabolic-status-in-patients-with-parkinson-s-disease-a-randomized-double-blind-placebo-controlled-trial
#18
Mohsen Taghizadeh, Omid Reza Tamtaji, Ehsan Dadgostar, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Javad Abolhassani, Mohammad Hossein Aarabi, Ebrahim Kouchaki, Mohammad Reza Memarzadeh, Zatollah Asemi
The current research was performed to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on clinical signs and metabolic status in people with Parkinson's disease (PD). This randomized double-blind placebo-controlled clinical trial was conducted in 60 patients with PD. Participants were randomly assigned into two groups to receive either 1000 mg omega-3 fatty acids from flaxseed oil plus 400 IU vitamin E supplements (n = 30) or placebo (n = 30) for 12 weeks. Unified Parkinson's disease rating stage (UPDRS) were recorded at baseline and the after 3-month intervention...
March 22, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28342951/a-model-to-identify-individuals-at-high-risk-for-esophageal-squamous-cell-carcinoma-and-precancerous-lesions-in-regions-of-high-prevalence-in-china
#19
Mengfei Liu, Zhen Liu, Hong Cai, Chuanhai Guo, Xiang Li, Chaoting Zhang, Hui Wang, Dong Hang, Fangfang Liu, Qiuju Deng, Xin Yang, Wenqing Yuan, Yaqi Pan, Jingjing Li, Chanyuan Zhang, Na Shen, Zhonghu He, Yang Ke
BACKGROUND & AIMS: We aimed to develop a population-based model to identify individuals at high-risk for esophageal squamous cell carcinoma (ESCC) in regions of China with a high prevalence of this cancer. METHODS: We collected findings from 15,073 permanent residents (45-69 years old) of 334 randomly selected villages in Hua County, Henan Province, China who underwent endoscopic screening (with iodine staining) for ESCC from January 2012 through September 2015...
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28342950/progression-of-unresected-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-to-cancer-a-systematic-review-and-meta-analysis
#20
Sang Hyun Choi, Seong Ho Park, Kyung Won Kim, Ja Youn Lee, Sang Soo Lee
BACKGROUND & AIMS: It is not clear how best to manage patients with low-risk intraductal papillary mucinous neoplasms (IPMNs) of the pancreas, because little is known about IPMN progression to cancer. We sought to determine the cumulative incidence of development of pancreatic cancer in persons with unresected IPMNs (particularly low-risk IPMNs). METHODS: We performed a systematic search of the MEDLINE and EMBASE databases, through November 31, 2016, for studies reporting the cumulative incidence of pancreatic cancer in patients with unresected IPMNs, or studies that provided data in sufficient detail for us to calculate cumulative incidence values...
March 22, 2017: Clinical Gastroenterology and Hepatology
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