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https://www.readbyqxmd.com/read/29243295/extended-phase-graph-formalism-for-systems-with-magnetization-transfer-and-exchange
#1
Shaihan J Malik, Rui Pedro A G Teixeira, Joseph V Hajnal
PURPOSE: An extended phase graph framework (EPG-X) for modeling systems with exchange or magnetization transfer (MT) is proposed. THEORY: EPG-X models coupled two-compartment systems by describing each compartment with separate phase graphs that exchange during evolution periods. There are two variants: EPG-X(BM) for systems governed by the Bloch-McConnell equations, and EPG-X(MT) for the pulsed MT formalism. For the MT case, the "bound" protons have no transverse components, so their phase graph consists of only longitudinal states...
December 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29241295/in-vitro-selection-and-characterization-of-dna-aptamers-to-a-small-molecule-target
#2
Annamaria Ruscito, Erin M McConnell, Anna Koudrina, Ranganathan Velu, Christopher Mattice, Vernon Hunt, Maureen McKeague, Maria C DeRosa
Aptamers, synthetic oligonucleotide-based molecular recognition probes, have found use in a wide array of biosensing technologies based on their tight and highly selective binding to a variety of molecular targets. However, the inherent challenges associated with the selection and characterization of aptamers for small molecule targets have resulted in their underrepresentation, despite the need for small molecule detection in fields such as medicine, the environment, and agriculture. This protocol describes the steps in the selection, sequencing, affinity characterization, and truncation of DNA aptamers that are specific for small molecule targets...
December 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/29240289/dnazyme-feedback-amplification-relaying-molecular-recognition-to-exponential-dna-amplification
#3
Meng Liu, Qingxin Yin, Erin McConnell, Yangyang Chang, John Brennan, Yingfu Li
Technologies capable of linking DNA amplification to molecular recognition are very desirable for ultrasensitive biosensing applications. We have developed a simple but powerful isothermal DNA amplification method, termed DNAzyme feedback amplification (DFA), that is capable of relaying molecular recognition to exponential DNA amplification. The method incorporates both an RNA-cleaving DNAzyme (RCD) and rolling circle amplification (RCA) carried out by a special DNA polymerase using a circular DNA template...
December 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29232699/cxcr4-blockade-decreases-cd4-t-cell-exhaustion-and-improves-survival-in-a-murine-model-of-polymicrobial-sepsis
#4
Kimberly M Ramonell, Wenxiao Zhang, Annette Hadley, Ching-Wen Chen, Katherine T Fay, John D Lyons, Nathan J Klingensmith, Kevin W McConnell, Craig M Coopersmith, Mandy L Ford
Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4 is a chemokine receptor that, following ligation by CXCL12, directs cells to bone marrow niches and also plays an important role in T cell cosignaling and formation of the immunological synapse. Here, we investigated the expression and function of CXCR4 in a murine model of polymicrobial sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/29225412/identity-victimization-and-support-facebook-experiences-and-mental-health-among-lgbtq-youth
#5
Elizabeth A McConnell, Antonia Clifford, Aaron K Korpak, Gregory Phillips, Michelle Birkett
The rise of social networking sites (SNSs) has created new contexts within which lesbian, gay, bisexual, transgender, and queer (LGBTQ) youth and young adults manage their social identities and relationships. On one hand, SNSs provide important social support; on the other, they comprise another realm for victimization and discrimination. Context collapse refers to the ways diverse subgroups (e.g., family, co-workers) are often united in Facebook networks, which presents unique challenges related to outness...
November 2017: Computers in Human Behavior
https://www.readbyqxmd.com/read/29223916/performance-of-cigarette-susceptibility-index-among-e-cigarette-and-hookah-users
#6
Jessica L Barrington-Trimis, Adam M Leventhal, Todd A Alonzo, Tess Boley Cruz, Robert Urman, Feifei Liu, Mary Ann Pentz, Jennifer B Unger, Rob McConnell
OBJECTIVE: Susceptibility to cigarette smoking has been used since the mid-1990s as a measure to identify youth at risk of cigarette initiation. However, it is unclear how well this measure predicts future smoking among electronic (e-)cigarette or hookah users, or among those in tobacco-friendly social environments. METHODS: We used prospective data from the Southern California Children's Health Study to evaluate the performance (sensitivity, specificity, predictive value) of a composite index assessing susceptibility to smoking, and to evaluate whether performance of the measure differed by use of e-cigarettes or hookah, or immersion in a tobacco-friendly social environment...
August 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29223912/prenatal-buprenorphine-exposure-and-neonatal-neurobehavioral-functioning
#7
Martha L Velez, Krystle McConnell, Nancy Spencer, Lina Montoya, Michelle Tuten, Lauren M Jansson
No abstract text is available yet for this article.
December 7, 2017: Early Human Development
https://www.readbyqxmd.com/read/29221475/a-critical-realist-evaluation-of-a-music-therapy-intervention-in-palliative-care
#8
Sam Porter, Tracey McConnell, Mike Clarke, Jenny Kirkwood, Naomi Hughes, Lisa Graham-Wisener, Joan Regan, Miriam McKeown, Kerry McGrillen, Joanne Reid
BACKGROUND: Music therapy is increasingly used as an adjunct therapy to support symptom management in palliative care. However, studies to date have paid little attention to the processes that lead to changes in patient outcomes. To fill this gap, we examined the processes and experiences involved in the introduction of music therapy as an adjunct complementary therapy to palliative care in a hospice setting in the United Kingdom (UK). METHODS: Using a realistic evaluation approach, we conducted a qualitative study using a variety of approaches...
December 8, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29220880/development-of-a-new-biochip-array-for-apoe4-classification-from-plasma-samples-using-immunoassay-based-methods
#9
Sigrun Badrnya, Tara Doherty, Ciaran Richardson, Robert I McConnell, John V Lamont, Michael Veitinger, Stephen P FitzGerald, Maria Zellner, Ellen Umlauf
BACKGROUND: Apolipoprotein E (APOE) is a key player in lipid transport and metabolism and exists in three common isoforms: APOE2, APOE3 and APOE4. The presence of the E4 allelic variant is recognized as a major genetic risk factor for dementia and other chronic (neuro)degenerative diseases. The availability of a validated assay for rapid and reliable APOE4 classification is therefore advantageous. METHODS: Biochip array technology (BAT) was successfully applied to identify directly the APOE4 status from plasma within 3 h, through simultaneous immunoassay-based detection of both specific APOE4 and total APOE levels...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29217086/effect-of-inhaled-allergens-and-air-pollutants-on-childhood-rhinitis-development
#10
Hui Zhou, Xia Iona Li, Jeong Hee Kim, Muhammad T Salam, Hyo Bin Kim, Rob S McConnell, Rima Habre, Tracy Bastain, Shohreh F Farzan, Jill Johnston, Frank D Gilliland
No abstract text is available yet for this article.
December 5, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29206033/aromaticity-driven-molecular-structural-variation-and-electronic-configuration-alternation-an-example-of-cyclic-%C3%AF-conjugation-involving-a-mo-mo-%C3%AE-bond
#11
Suman Mallick, Ye Lu, Ming Hui Luo, Miao Meng, Ying Ning Tan, Chun Y Liu, Jing-Lin Zuo
We have synthesized and characterized the mixed-ligand dimolybdenum paddlewheel complex Na[(DAniF)3Mo2(C3S5)] (Na[1]; DAniF = N,N'-di-p-anisylformamidinate, dmit = 1,3-dithiole-2-thione-4,5-dithiolate), which has a six-membered chelating [Mo2S2C2] ring created by equatorial coordination of the dmit (C3S5) ligand to the Mo2 unit. One-electron oxidation of Na[1] using Cp2FePF6 yields the neutral complex [(DAniF)3Mo2(C3S5)] ([1]), and removal of two electrons from Na[1] using AgBPh4 gives [(DAniF)3Mo2(C3S5)]BPh4 ([1]BPh4)...
December 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29205091/polysomnographic-oxygen-saturation-findings-for-preteen-children-versus-adolescents
#12
Nathan D Wiebracht, Shan He, Colin Cotton, Jareen Meinzen-Derr, Gordon Shott, David F Smith, Keith B McConnell, Stacey L Ishman
Objective Home oximetry is commonly used to screen for obstructive sleep apnea (OSA) in children; however, normal oxygen desaturation levels by disease severity are not well known. It was our objective to determine if oxygen saturation levels differed by OSA severity category in children and if these differences were similar for preteen children and adolescents. Study Design Retrospective case series of children undergoing polysomnography from September 2011 to July 2015. Setting Tertiary pediatric hospital...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29197172/sleep-patterns-predictive-of-daytime-challenging-behavior-in-individuals-with-low-functioning-autism
#13
Simonne Cohen, Ben D Fulcher, Shantha M W Rajaratnam, Russell Conduit, Jason P Sullivan, Melissa A St Hilaire, Andrew J K Phillips, Tobias Loddenkemper, Sanjeev V Kothare, Kelly McConnell, Paula Braga-Kenyon, William Ahearn, Andrew Shlesinger, Jacqueline Potter, Frank Bird, Kim M Cornish, Steven W Lockley
Increased severity of problematic daytime behavior has been associated with poorer sleep quality in individuals with autism spectrum disorder. In this work, we investigate whether this relationship holds in a real-time setting, such that an individual's prior sleep can be used to predict their subsequent daytime behavior. We analyzed an extensive real-world dataset containing over 20,000 nightly sleep observations matched to subsequent challenging daytime behaviors (aggression, self-injury, tantrums, property destruction and a challenging behavior index) across 67 individuals with low-functioning autism living in two U...
December 1, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29185070/single-cell-analysis-of-diversity-in-human-stem-cell-derived-neurons
#14
REVIEW
Lise J Harbom, Nadine Michel, Michael J McConnell
Neural stem and progenitor cells produce one of the most remarkable organs in nature, the human brain. Among neural stem cell progeny, post-mitotic neurons are likewise remarkably diverse. Single-cell transcriptomic approaches are now cataloging a long-sought-after molecular taxonomy of neuronal diversity in the brain. Contemporary single-cell omic classifications of neuronal diversity build from electrophysiological approaches that for decades have measured and cataloged diverse biophysical properties of single neurons...
November 29, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29182634/direct-provision-versus-facility-collection-of-hiv-self-tests-among-female-sex-workers-in-uganda-a-cluster-randomized-controlled-health-systems-trial
#15
Katrina Ortblad, Daniel Kibuuka Musoke, Thomson Ngabirano, Aidah Nakitende, Jonathan Magoola, Prossy Kayiira, Geoffrey Taasi, Leah G Barresi, Jessica E Haberer, Margaret A McConnell, Catherine E Oldenburg, Till Bärnighausen
BACKGROUND: HIV self-testing allows HIV testing at any place and time and without health workers. HIV self-testing may thus be particularly useful for female sex workers (FSWs), who should test frequently but face stigma and financial and time barriers when accessing healthcare facilities. METHODS AND FINDINGS: We conducted a cluster-randomized controlled health systems trial among FSWs in Kampala, Uganda, to measure the effect of 2 HIV self-testing delivery models on HIV testing and linkage to care outcomes...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29181353/pyomyositis-of-gluteus-medius-a-case-report-and-review-of-the-literature
#16
Raviprasad Kattimani, Jamie McConnell, Jon Waite
Introduction: We present a case of 12 year old boy presented with right hip pain, fever and antalgic gait. Inflammatory markers were raised at presentation. The pelvic radiograph and ultra sound scan of right hip joint did not detect any abnormality. The Magnetic Resonance Imaging (MRI) scans revealed inflammatory oedema in the right gluteus medius muscle. He was treated with intravenous Flucloxacillin for 10 days and later 6 weeks of oral Flucloxacillin. At the 6 weeks follow up patient was asymptomatic with normal gait...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29180399/diminished-microrna-29b-level-is-associated-with-brd4-mediated-activation-of-oncogenes-in-cutaneous-t-cell-lymphoma
#17
Rebecca Kohnken, Jing Wen, Bethany Mundy-Bosse, Kathleen McConnell, Ashleigh Keiter, Leah Grinshpun, Alex Hartlage, Max Yano, Betina McNeil, Nitin Chakravarti, Basem William, James E Bradner, Michael A Caligiuri, Pierluigi Porcu, Anjali Mishra
MicroRNA dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), a uniformly fatal malignancy of skin-homing CD4+ T-cells for which there are few effective therapies. The role of microRNAs (miRs) in controlling epigenetic modifier-dependent transcriptional regulation in CTCL is unknown. In this study, we characterize a novel miR dysregulation contributing to overexpression of epigenetic reader bromodomain-containing protein 4 (BRD4). Using patient CD4+ T-cells, we show diminished levels of miR-29b compared to healthy donor cells...
November 27, 2017: Blood
https://www.readbyqxmd.com/read/29176114/adverse-childhood-experiences-ace-among-american-indians-in-south-dakota-and-associations-with-mental-health-conditions-alcohol-use-and-smoking
#18
Donald Warne, Kristen Dulacki, Margaret Spurlock, Thomas Meath, Melinda M Davis, Bill Wright, K John McConnell
OBJECTIVES: To assess the prevalence of Adverse Childhood Experiences (ACEs) and their association with behavioral health in American Indian (AI) and non-AI populations in South Dakota. METHODS: We included the validated ACE questionnaire in a statewide health survey of 16,001 households. We examined the prevalence of ACEs and behavioral health conditions in AI and non-AI populations and associations between ACEs and behavioral health. RESULTS: Compared with non-AIs, AIs displayed higher prevalence of ACEs including abuse, neglect, and household dysfunction and had a higher total number of ACEs...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/29174833/does-prescription-opioid-shopping-increase-overdose-rates-in-medicaid-beneficiaries
#19
Benjamin C Sun, Nicoleta Lupulescu-Mann, Christina J Charlesworth, Hyunjee Kim, Daniel M Hartung, Richard A Deyo, K John McConnell
STUDY OBJECTIVE: The link between prescription opioid shopping and overdose events is poorly understood. We test the hypothesis that a history of prescription opioid shopping is associated with increased risk of overdose events. METHODS: This is a secondary analysis of a linked claims and controlled substance dispense database. We studied adult Medicaid beneficiaries in 2014 with prescription opioid use in the 6 months before an ambulatory care or emergency department visit with a pain-related diagnosis...
November 23, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29174560/resident-vignettes-for-assessing-care-quality-in-nursing-homes
#20
Cathleen S Colón-Emeric, Kirsten N Corazzini, Eleanor S McConnell, Wei Pan, Mark P Toles, Rasheeda Hall, Melissa Batchelor-Murphy, Tracey L Yap, Amber L Anderson, Andrew Burd, Sathya Amarasekara, Ruth A Anderson
OBJECTIVES: Validated process measures that correlate with patient outcomes are needed for research and quality improvement. DESIGN: Cross-sectional analysis within a cluster-randomized fall prevention study. SETTING: Nursing homes in North Carolina (n = 16). PARTICIPANTS: Nursing home staff (n = 541) and residents with 1 or more falls in 6 months (n = 597). MEASUREMENTS: Fall-prevention process measures in 4 categories derived from Assessing Care of Vulnerable Elders quality indicators were measured in 2 ways: (1) chart abstraction; and (2) staff responses to clinical vignettes of hypothetical residents at risk for falls...
November 21, 2017: Journal of the American Medical Directors Association
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