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https://www.readbyqxmd.com/read/27875677/a-case-report-of-pregnancy-during-use%C3%A2-of-targeted-therapeutics-for-cystic%C3%A2-fibrosis
#1
Sigrid Ladores, Traci M Kazmerski, Steven M Rowe
New therapeutics, such as ivacaftor, and the combination drug lumacaftor/ivacaftor that target the underlying genetic cause of cystic fibrosis are being hailed as game-changers in this era of personalized medicine. Although these drugs improve lung function, their effects on female fertility have not been studied. In this case report we describe one woman's experience with ivacaftor and her unanticipated pregnancy. Implications related to comprehensive sexual and reproductive health care for women with cystic fibrosis are presented...
November 19, 2016: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/27870255/now-that-is-a-game-changer-the-entire-reproductive-cycle-of-an-oocyte-in-a-dish
#2
EDITORIAL
Gary M Wessel
No abstract text is available yet for this article.
November 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27856340/pok%C3%A3-mon-go-a-game-changer-for-the-physical-inactivity-crisis
#3
Allana G LeBlanc, Jean-Philippe Chaput
There is an urgent need to find novel strategies aimed at motivating people to go outside and move more. Pokémon Go blends a fun smartphone game with real-life, outdoor physical activity. Initial reports suggest it is a successful population level strategy to increase physical activity levels. Further research is needed to understand the long-term risks and benefits of this new game. Free-to-play location-based augmented reality mobile games are likely to be a new model for promoting healthy active living in the future...
November 14, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27853680/radiolabeled-theranostics-magnetic-and-gold-nanoparticles
#4
REVIEW
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar, Yadollah Omidi
Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27826536/pembrolizumab-as-first-line-treatment-for-non-small-cell-lung-cancer-a-game-changer
#5
EDITORIAL
Wolfram C M Dempke, Klaus Fenchel
No abstract text is available yet for this article.
October 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/27819687/impact-of-drug-development-on-the-use-of-stem-cell-transplantation-a-report-by-the-european-society-for-blood-and-marrow-transplantation-ebmt
#6
J R Passweg, H Baldomero, P Bader, C Bonini, S Cesaro, P Dreger, R F Duarte, C Dufour, J Kuball, D Farge-Bancel, A Gennery, N Kröger, F Lanza, A Nagler, A Sureda, M Mohty
Hematopoietic stem cell transplantation (HSCT) is used with increasing frequency in Europe with 40 000 transplants reported in 2014. Transplant-related mortality remains high in allogeneic HSCT (10-20%); high-dose chemotherapy is toxic and demanding for patients. Drug development is accelerating and with limited toxicity of some targeted drugs may replace HSCT, whereas others may function as a 'bridge to transplant'. We analyzed HSCT reported to the activity survey for selected diseases in which major advances in drug development have been made...
November 7, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27817950/sutureless-aortic-valves-a-game-changer-or-niche-tool-in-an-expanding-toolbox
#7
EDITORIAL
Davis C Drinkwater
No abstract text is available yet for this article.
October 14, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27800282/digital-suicide-prevention-can-technology-become-a-game-changer
#8
REVIEW
Arshya Vahabzadeh, Ned Sahin, Amir Kalali
Suicide continues to be a leading cause of death and has been recognized as a significant public health issue. Rapid advances in data science can provide us with useful tools for suicide prevention, and help to dynamically assess suicide risk in quantitative data-driven ways. In this article, the authors highlight the most current international research in digital suicide prevention, including the use of machine learning, smartphone applications, and wearable sensor driven systems. The authors also discuss future opportunities for digital suicide prevention, and propose a novel Sensor-driven Mental State Assessment System...
May 2016: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/27776582/e-cigarettes-a-need-to-broaden-the-debate
#9
E Latif, M Nair
The unregulated market for e-cigarettes continues to grow, with debates on their efficacy and impact on global public health. E-cigarettes, or electronic nicotine delivery systems (ENDs), are marketed as a 'safe' alternative to tobacco products and a tool for 'harm reduction'. Some public health experts are calling it a 'game changer' and favour the 'harm reduction' strategy, while others dispute this claim. In our opinion, the debate needs to be broadened to encompass other related concerns and effects on non-users and affected stakeholders...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27774519/radiotherapy-changing-the-game-in-immunotherapy
#10
Sandra Demaria, C Norman Coleman, Silvia C Formenti
Immune checkpoint inhibitors are effective in cancer treatment. A pre-existing immune response demonstrated by significant pretreatment tumor lymphocytic infiltration is a pre-requisite for response. Within such infiltrated tumors, referred as "hot", immune checkpoint inhibitors rescue anti-tumor T cells activity. In contrast, "cold" tumors lack lymphocytic infiltration and are refractory to immunotherapy. Preclinical data show that radiotherapy sensitizes refractory tumors to immune checkpoint inhibitors by recruiting anti-tumor T cells...
June 2016: Trends in Cancer
https://www.readbyqxmd.com/read/27760688/prep-implementation-in-the-asia-pacific-region-opportunities-implementation-and-barriers
#11
Iryna Zablotska, Andrew E Grulich, Nittaya Phanuphak, Tarandeep Anand, Surang Janyam, Midnight Poonkasetwattana, Rachel Baggaley, Frits van Griensven, Ying-Ru Lo
INTRODUCTION: HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. DISCUSSION: Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27716813/human-resources-for-treating-hiv-aids-are-the-preventive-effects-of-antiretroviral-treatment-a-game-changer
#12
Till Bärnighausen, David E Bloom, Salal Humair
Shortages of human resources for treating HIV/AIDS (HRHA) are a fundamental barrier to reaching universal antiretroviral treatment (ART) coverage in developing countries. Previous studies suggest that recruiting HRHA to attain universal ART coverage poses an insurmountable challenge as ART significantly increases survival among HIV-infected individuals. While new evidence about ART's prevention benefits suggests fewer infections may mitigate the challenge, new policies such as treatment-as-prevention (TasP) will exacerbate it...
2016: PloS One
https://www.readbyqxmd.com/read/27698527/game-changers
#13
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Ulster Medical Journal
https://www.readbyqxmd.com/read/27672665/the-rise-and-the-fall-of-betatrophin-angptl8-as-an-inducer-of-%C3%AE-cell-proliferation
#14
Mohamed Abu-Farha, Ashraf Al Madhoun, Jehad Abubaker
Diabetes is a global health problem that is caused by impaired insulin production from pancreatic β-cells. Efforts to regenerate β-cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induce β-cells regeneration. ANGPTL8, also named betatrophin, has been recently identified as a hormone capable of inducing β-cells proliferation and increasing β-cells mass in rodents. Its discovery has been cherished as a breakthrough and a game changer in the field of β-cells regeneration...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27638722/genetic-markers-as-therapeutic-target-in-rheumatoid-arthritis-a-game-changer-in-clinical-therapy
#15
A M Mohamed Thoufic Ali, S Vino
Rheumatoid arthritis (RA) is a chronic, inflammatory, multi-systemic autoimmune disease unremitted by genetic and environmental factors. The factors are crucial but inadequate in the development of disease; however, these factors can be representative of potential therapeutic targets and response to clinical therapy. Insights into the contribution of genetic risk factors are currently in progress with studies querying the genetic variation, their role in gene expression of coding and non-coding genes and other mechanisms of disease...
November 2016: Rheumatology International
https://www.readbyqxmd.com/read/27573627/the-tropical-disease-priority-review-voucher-a-game-changer-for-tropical-disease-products
#16
Jonathan Berman, Tanya Radhakrishna
The neglected tropical disease priority review voucher (PRV) program ("tropical disease voucher," "voucher") is a U.S. government program intended to enlarge the number of products approved for tropical diseases in the United States. Ridley and others noted that "Infectious and parasitic diseases create enormous health burdens, but because most of the people suffering from these diseases are poor, little is invested in developing treatments." In 2006, these academicians proposed, and in 2007, the U.S. Congress enacted a new section 524 to the Federal Food, Drug, and Cosmetic Act (21 U...
August 29, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27567280/gemcitabine-a-game-changer-in-nasopharyngeal-carcinoma
#17
COMMENT
Melvin L K Chua, Anthony T C Chan
No abstract text is available yet for this article.
October 15, 2016: Lancet
https://www.readbyqxmd.com/read/27526561/-fractionated-stereotactic-radiosurgery-a-game-changer-for-neurosurgery
#18
EDITORIAL
Ouzi Nissim, Roberto Spiegelmann
The article by Dr. Cohen-Inbar published in this issue of Harefuah is a timely review that brings to the general medical community the recent important developments in the field of radiosurgery--the evolution of multi-session radiosurgery [or "FSR", standing for Fractionated Stereotactic Radiation]. Radiosurgery and FSR continue to have a tremendous impact on modern neurosurgery. Sharing sub-millimetric accuracy in radiation delivery made possible by real-time-imaging positioning, frameless single and multisession radiosurgery have become two faces of a therapeutic technique with wide application in the field of intracranial pathology...
May 2016: Harefuah
https://www.readbyqxmd.com/read/27440495/endpoints-for-therapeutic-interventions-in-faecal-incontinence-small-step-or-game-changer
#19
REVIEW
S S C Rao
Faecal incontinence (FI) is common and its pathophysiology and treatments continue to evolve. However, a standard measure(s) for assessing its clinical outcome has been elusive. Consequently, over 100 measures and scoring systems, each with intrinsic biases have been reported. These include adequate relief or global satisfaction, ≥50% reduction in episodes or days without FI, quality of life (QOL), FI severity scales and composite indices. Earlier scales relied on the frequency and type of solid, liquid or flatus incontinence and effects on life style whereas newer scales have incorporated urgency, use of pads, antidiarrhoeals and amount of leakage, using prospective daily stool diaries or retrospective weekly or single point assessments...
August 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27429660/immune-checkpoint-blockade-in-ovarian-cancer
#20
Lukas Weiss, Florian Huemer, Brigitte Mlineritsch, Richard Greil
Increased numbers of tumour infiltrating T‑cells have long been associated with a better prognosis in ovarian cancer, which has led to the general assumption of a relevant impact of T‑cellular anti-tumour immunity in this disease. As a consequence of this knowledge, a multitude of immunologic therapies has emerged over the past years. Although some reports could evidence a successful induction of anti-tumour T‑cells, in general, these attempts did not translate into clinically significant activity...
2016: Memo
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