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https://www.readbyqxmd.com/read/28729242/heading-for-trouble-is-dementia-a-game-changer-for-football
#1
EDITORIAL
A Rutherford, William Stewart, Davide Bruno
No abstract text is available yet for this article.
July 20, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28725217/metagenomics-the-next-culture-independent-game-changer
#2
REVIEW
Jessica D Forbes, Natalie C Knox, Jennifer Ronholm, Franco Pagotto, Aleisha Reimer
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories is at a crossroads with the ability of public health agencies to perform their basic mandate of foodborne disease surveillance and response. The implementation of culture-independent diagnostic tests (CIDTs) including nucleic acid and antigen-based assays for acute gastroenteritis is leaving public health agencies without laboratory evidence to link clinical cases to each other and to food or environmental substances...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28723999/moving-towards-south-south-international-health-debts-and-challenges-in-the-regional-health-agenda
#3
María Belén Herrero
The aim of this paper is twofold. First, it aims to investigate the increased interest in health as an important dimension of the foreign policy and diplomatic concerns together with the emergence of a new framework for regional health integration and regional health diplomacy. Second, it seeks to understand the role and practices of new regional blocs in the field of health and whether they are conducting to the emergence of new strategies for addressing health regional policies in South America. The regional policy process relates to health as a right...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28715943/introducing-treat-to-target-strategies-of-autoimmune-extrahepatic-manifestations-of-chronic-hepatitis-c-virus-infection
#4
Soledad Retamozo, Pilar Brito-Zerón, Luca Quartuccio, Salvatore De Vita, Manuel Ramos-Casals
The hepatitis C virus (HCV) is recognized as one of the hepatic viruses most often associated with extrahepatic manifestations (EHMs). It is currently accepted that cryoglobulinemic vasculitis (CV) is the key autoimmune extrahepatic disease associated with HCV infection. Therapeutic approaches have mainly been based on the use of old antiviral interferon (IFN)-based regimens and immunosuppressive therapies, often with an inadequate balance between therapeutic benefits and excess side effects. Areas covered: Therapeutic management of HCV patients with EHMs, including both non-autoimmune (cardiovascular, hematological, general features) and autoimmune complications (organ-specific and systemic autoimmune diseases)...
July 27, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28696529/fast-dynamic-visualizations-in-microfluidics-enabled-by-fluorescent-carbon-nanodots
#5
Yi Huang, Lian Xiao, Tingting An, Wenxiang Lim, Teckneng Wong, Handong Sun
Microfluidic systems have become a superior platform for explorations of fascinating fluidic physics at microscale as well as applications in biomedical devices, chemical reactions, drug delivery, etc. Exploitations of this platform are built upon the fundamental techniques of flow visualizations. However, the currently employed fluorescent materials for microfluidic visualization are far from satisfaction, which severely hinders their widespread applications. Here fluorescent carbon nanodots are documented as a game-changer, applicable in versatile fluidic environment for the visualization in microfluidics with unprecedented advantages...
July 11, 2017: Small
https://www.readbyqxmd.com/read/28693853/multidrug-therapy-for-leprosy-a-game-changer-on-the-path-to-elimination
#6
REVIEW
Cairns S Smith, Ann Aerts, Paul Saunderson, Joseph Kawuma, Etsuko Kita, Marcos Virmond
Leprosy is present in more than 100 countries, where it remains a major cause of peripheral neuropathy and disability. Attempts to eliminate the disease have faced various obstacles, including characteristics of the causative bacillus Mycobacterium leprae: the long incubation period, limited knowledge about its mode of transmission, and its poor growth on culture media. Fortunately, the leprosy bacillus is sensitive to several antibiotics. The first antibiotic to be widely used for leprosy treatment was dapsone in the 1950s, which had to be taken over several years and was associated with increasing bacterial resistance...
July 7, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28692305/fight-fire-with-fire-gene-therapy-strategies-to-cure-hiv
#7
Jon Huyghe, Sips Magdalena, Linos Vandekerckhove
Human Immunodeficiency Virus (HIV) to date remains one of the most notorious viruses mankind has ever faced. Despite enormous investments in HIV research for more than 30 years an effective cure for HIV has been elusive. Areas covered: Combination antiretroviral therapy (cART) suppresses active viral replication, but is not able to eliminate the virus completely due to stable integration of HIV inside the host genome of infected cells and the establishment of a latent reservoir, that is insensitive to cART...
July 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28677428/support-grows-for-essential-hiv-prevention-drug
#8
Jennifer Trueland
The HIV prevention treatment PrEP has been hailed a game-changer, with the potential to transform people's lives and save the NHS hundreds of thousands of pounds per patient in lifetime costs.
July 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28653006/laparoscopic-liver-resection-for-hepatocellular-carcinoma-in-cirrhotic-patients-a-potential-game-changer-toward-global-standardization-of-care
#9
EDITORIAL
Taizo Hibi, Yuko Kitagawa
No abstract text is available yet for this article.
June 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28638166/will-real-time-monitoring-technology-be-a-game-changer-for-perfusion-safety
#10
Linda B Mongero
No abstract text is available yet for this article.
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28630366/a-game-changer-for-hereditary-cancer-patients
#11
Brit Cooper-Jones, Katelyn Verstraten
No abstract text is available yet for this article.
June 19, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28611985/adaptation-through-collaboration-developing-novel-platforms-to-advance-the-delivery-of-advanced-therapies-to-patients
#12
REVIEW
Magdalini Papadaki
For the nascent field of advanced therapies, collaboration will be a game-changer, turning scientific progress that was once unimaginable into transformative medical practice. Despite promise for lifelong management and even cure of disease, skepticism remains about the feasibility of their delivery to patients, fueling investment risks. With the potential for long-term effectiveness in need of frequent reassessment, current approaches to predict real-life drug performance bear little relevance, necessitating novel and iterative schemes to monitoring the benefit-risk profiles throughout the life span of advanced therapies...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28601415/brain-autoimmunity-and-intestinal-microbiota-100-trillion-game-changers
#13
REVIEW
Hartmut Wekerle
T cells play a critical role in autoimmune diseases in the brain, particularly in multiple sclerosis (MS). Since T cells are normally prevented from crossing the blood-brain barrier (BBB), autoimmunity requires prior activation of naturally occurring autoreactive T cells in peripheral tissue. Recently, a critical role for the microbiota in this activation process has emerged. Here, we review the role of gut-associated lymphoid tissues (GALT) as a major site for the phenotypic changes that allow the migration of autoreactive T cells to the brain...
July 2017: Trends in Immunology
https://www.readbyqxmd.com/read/28590032/epithelial-mesenchymal-transition-in-cancer-metastasis-through-the-lymphatic-system
#14
REVIEW
Mikael C Karlsson, Santiago F Gonzalez, Josefin Welin, Jonas Fuxe
It was already in the 18th century when the French surgeon LeDran first noted that breast cancer patients with spread of tumor cells to their axillary lymph nodes had a drastically worse prognosis than patients without spread (LeDran et al., ). Since then, metastatic spread of cancer cells to regional lymph nodes has been established as the most important prognostic factor in many types of cancer (Carter et al., ; Elston and Ellis, ). However, despite its clinical importance, lymph metastasis remains an underexplored area of tumor biology...
July 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28585344/a-game-changer-a-multifunctional-perovskite-exhibiting-giant-ferroelectricity-and-narrow-bandgap-with-potential-application-in-a-truly-monolithic-multienergy-harvester-or-sensor
#15
Yang Bai, Pavel Tofel, Jaakko Palosaari, Heli Jantunen, Jari Juuti
An ABO3 -type perovskite solid-solution, (K0.5 Na0.5 )NbO3 (KNN) doped with 2 mol% Ba(Ni0.5 Nb0.5 )O3-δ (BNNO) is reported. Such a composition yields a much narrower bandgap (≈1.6 eV) compared to the parental composition-pure KNN-and other widely used piezoelectric and pyroelectric materials (e.g., Pb(Zr,Ti)O3 , BaTiO3 ). Meanwhile, it exhibits the same large piezoelectric coefficient as that of KNN (≈100 pC N(-1) ) and a much larger pyroelectric coefficient (≈130 µC m(-2) K(-1) ) compared to the previously reported narrow-bandgap material (KNbO3 )1-x -BNNOx ...
June 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28579359/evolution-in-treatment-strategy-for-metastatic-spine-disease-presently-evolving-modalities
#16
REVIEW
N Kumar, R Malhotra, A S Zaw, K Maharajan, N Naresh, A Kumar, B Vellayappan
The advent of minimally invasive surgery (MIS) in the surgical management armamentarium and stereotactic radiosurgery in the domain of radiotherapy, has led to a major evolution in treatment of metastatic spine disease (MSD). We reviewed the recent literature to discuss evolution from open to MIS approaches in MSD and the concurrent evolution in radiotherapy. This will provide a sound base for further development and understanding of treatment paradigms in MSD. Literature review showed that evolution of surgery can be traced from inappropriate open surgery (i...
May 17, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28574731/why-gene-editors-like-crispr-cas-may-be-a-game-changer-for-neuroweapons
#17
Diane DiEuliis, James Giordano
This year marks the Eighth Review Conference (RevCon) of the Biological Toxins and Weapons Convention (BWC). At the same time, ongoing international efforts to further and more deeply investigate the brain's complex neuronal circuitry are creating unprecedented capabilities to both understand and control neurological processes of thought, emotion, and behavior. These advances have tremendous promise for human health, but the potential for their misuse has also been noted, with most discussions centering on research and development of agents that are addressed by existing BWC and Chemical Weapons Convention (CWC) proscriptions...
May 2017: Health Security
https://www.readbyqxmd.com/read/28558662/evaluation-of-gene-xpert-for-routine-diagnosis-of-hiv-associated-tuberculosis-in-nigeria-a-prospective-cohort-study
#18
Maxwell Oluwole Akanbi, Chad Achenbach, Babafemi Taiwo, John Idoko, Agatha Ani, Yetunde Isa, Oche Agbaji, Christiana Ukoli, Patrick Akande, Mamoudou Maiga, Robert Leo Murphy
BACKGROUND: Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of Xpert on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB in Nigeria. METHODS: Adults with HIV being evaluated for pulmonary TB (PTB) were consecutively enrolled into the study cohort. At baseline, expectorated sputa were examined using Xpert and smear microscopy for Mycobacterium tuberculosis (MTB) and acid fast bacilli, respectively...
May 30, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28555551/-economic-crisis-and-portuguese-national-health-service-physicians-findings-from-a-descriptive-study-of-their-perceptions-and-reactions-from-health-care-units-in-the-greater-lisbon-area
#19
Inês Rego, Giuliano Russo, Luzia Gonçalves, Julian Perelman, Pedro Pita Barros
INTRODUCTION: In Europe, scant scientific evidence exists on the impact of economic crisis on physicians. This study aims at understanding the adjustments made by public sector physicians to the changing conditions, and their perceptions on the market for medical services in the Lisbon metropolitan area. MATERIAL AND METHODS: A random sample of 484 physicians from São José Hospital and health center groups in Cascais and Amadora, to explore their perceptions of the economic crisis, and the changes brought to their workload...
April 28, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28537437/-it-is-definitely-a-game-changer-a-qualitative-study-of-experiences-with-in-home-overnight-closed-loop-technology-among-adults-with-type-1-diabetes
#20
Christel Hendrieckx, Lucinda A Poole, Amin Sharifi, Dilshani Jayawardene, Margaret M Loh, Jodie C Horsburgh, Leon A Bach, Peter G Colman, Kavita Kumareswaran, Alicia J Jenkins, Richard J MacIsaac, Glenn M Ward, Benyamin Grosman, Anirban Roy, David N O'Neal, Jane Speight
BACKGROUND: This qualitative study explored trial participants' experiences of four nights of in-home closed loop. METHODS: Sixteen adults with type 1 diabetes, who completed a randomized crossover trial, were interviewed after four consecutive nights of closed-loop. Interviews were audio recorded, transcribed, and analyzed with a coding framework developed to identify the main themes. RESULTS: Participants had a mean age of 42 ± 10 years, nine were women; mean diabetes duration was 27 ± 7 years, and all were using insulin pumps...
July 2017: Diabetes Technology & Therapeutics
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