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https://www.readbyqxmd.com/read/29341913/characterisation-of-pore-structures-of-pharmaceutical-tablets-a-review
#1
REVIEW
Daniel Markl, Alexa Strobel, Rüdiger Schlossnikl, Johan Bøtker, Prince Bawuah, Cathy Ridgway, Jukka Rantanen, Thomas Rades, Patrick Gane, Kai-Erik Peiponen, J Axel Zeitler
Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29330699/accounting-of-ghg-emissions-and-removals-from-forest-management-a-long-road-from-kyoto-to-paris
#2
REVIEW
Joachim H A Krug
BACKGROUND: Forests have always played an important role in agreeing on accounting rules during the past two decades of international climate policy development. Starting from activity-based gross-net accounting of selected forestry activities to mandatory accounting against a baseline-rules have changed quite rapidly and with significant consequences for accounted credits and debits. Such changes have direct consequences on incentives for climate-investments in forestry. There have also been strong arguments not to include forests into the accounting system by considering large uncertainties, procedural challenges and a fear of unearned credits corrupting the overall accounting system, among others...
January 3, 2018: Carbon Balance and Management
https://www.readbyqxmd.com/read/29312977/extracellular-vesicles-in-bile-a-game-changer-in-the-diagnosis-of-indeterminate-biliary-stenoses
#3
EDITORIAL
Seung Bae Yoon, Jae Hyuck Chang
No abstract text is available yet for this article.
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29304962/editorial-commentary-three-dimensional-printing-and-stem-cells-may-be-a-game-changer-for-recovery-after-anterior-cruciate-ligament-reconstruction
#4
EDITORIAL
Vipool K Goradia
Placing stem cells at the tendon-bone interface of a soft tissue anterior cruciate ligament (ACL) reconstruction in an animal model accelerates graft incorporation at 12 weeks. A 3D-printed scaffold used to deliver the stem cells completely degraded at 12 weeks. Future clinical application of similar technology may improve outcomes after ACL reconstruction.
January 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29286056/sacubitril-and-valsartan-fixed-combination-to-reduce-heart-failure-events-in-post-acute-myocardial-infarction-patients
#5
M Zaid Iskandar, C C Lang
Heart failure is a term used to define a constellation of symptoms and signs that are commonly attributed to the inability of the heart to produce a cardiac output that meets the demands of the body. It remains a deadly disease, affecting between 1-2% of the population, and is more common in the elderly, with around 6-10% of patients over 65 suffering from the condition. Sacubitril/valsartan (LCZ-696) is a combined neprilysin inhibitor and angiotensin AT1 receptor blocker approved in recent years for the treatment of chronic heart failure with reduced ejection fraction...
October 2017: Drugs of Today
https://www.readbyqxmd.com/read/29274719/hyperactive-factor-ix-padua-a-game-changer-for-hemophilia-gene-therapy
#6
Thierry VandenDriessche, Marinee K Chuah
No abstract text is available yet for this article.
January 3, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29244094/a-game-changer-for-the-aesthetic-surgery-journal
#7
Foad Nahai, Jeffrey M Kenkel
No abstract text is available yet for this article.
December 13, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29232103/game-changers-new-%C3%AE-lactamase-inhibitor-combinations-targeting-antibiotic-resistance-in-gram-negative-bacteria
#8
Karen Bush
Recent regulatory approvals for the β-lactam inhibitor combinations of ceftazidime-avibactam and meropenem-vaborbactam have provided two novel therapeutic options for the treatment of multidrug-resistant infections caused by Gram-negative bacteria. Most importantly, these combination agents have satisfied an important medical need related to antibiotic-resistant Klebsiella pneumoniae that produce serine carbapenemases, especially the Klebsiella pneumoniae carbapenemase (KPC) enzymes. Both combinations contain non-β-lactam β-lactamase inhibitors of novel chemical classes not previously developed as antibacterial agents, the diazabicyclooctanes and cyclic boronic acid derivatives...
December 12, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29216016/why-the-cantos-is-a-game-changer-in-cardiovascular-medicine
#9
Antonio Abbate
No abstract text is available yet for this article.
December 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29214315/will-the-fda-s-new-tobacco-strategy-be-a-game-changer
#10
Rita Rubin
No abstract text is available yet for this article.
December 6, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29184675/possible-application-of-circulating-free-tumor-dna-in-non-small-cell-lung-cancer-patients
#11
REVIEW
Niki Karachaliou, Aaron E Sosa, Miguel Angel Molina, Margarita Centelles Ruiz, Rafael Rosell
Liquid biopsies have been heralded as a game changer in cancer management. Blood tests offer a minimally invasive, safe and sensitive complementary (or even alternative) approach for tissue biopsies. With lung cancer being the second most commonly diagnosed cancer and the leading cause of cancer deaths worldwide, due to the limitations of tissue sampling, liquid biopsies must urgently materialize in the clinic. In this short review, we will present the current applications of cell-free DNA (cfDNA) in lung cancer management, emphasizing on our own experience and previous work...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29173353/extracellular-microvesicles-as-game-changers-in-better-understanding-the-complexity-of-cellular-interactions-from-bench-to-clinical-applications
#12
REVIEW
Mariusz Z Ratajczak, Janina Ratajczak
Recent research has led to wide acceptance and better understanding of a novel mechanism for cell-cell communication that employs a network of extracellular microvesicles (ExMVs). Derived from the plasma membrane or the endosomal membrane compartment, these small, spherical membrane fragments are secreted from the cell surface or in the process of exocytosis from endosomal membrane compartment and (1) with ligands expressed on their surface directly stimulate target cells in a paracrine manner, (2) transfer cell membrane receptors to target cells or (3) deliver encapsulated messenger RNA, microRNA, proteins and bioactive lipids to target cells...
November 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29147698/molecular-spin-qudits-for-quantum-algorithms
#13
REVIEW
Eufemio Moreno-Pineda, Clément Godfrin, Franck Balestro, Wolfgang Wernsdorfer, Mario Ruben
Presently, one of the most ambitious technological goals is the development of devices working under the laws of quantum mechanics. One prominent target is the quantum computer, which would allow the processing of information at quantum level for purposes not achievable with even the most powerful computer resources. The large-scale implementation of quantum information would be a game changer for current technology, because it would allow unprecedented parallelised computation and secure encryption based on the principles of quantum superposition and entanglement...
November 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29120330/ipan-the-game-changer
#14
Anupam Sachdeva
No abstract text is available yet for this article.
October 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29101220/the-glymphatic-mechanism-for-solute-clearance-in-alzheimer-s-disease-game-changer-or-unproven-speculation
#15
REVIEW
Alex J Smith, Alan S Verkman
How solutes and macromolecules are removed from brain tissue is of central importance in normal brain physiology and in how toxic protein aggregates are cleared in neurodegenerative conditions, including Alzheimer's disease (AD). Conventionally, solute transport in the narrow and tortuous extracellular space in brain parenchyma has been thought to be primarily diffusive and nondirectional. The recently proposed "glymphatic" (glial-lymphatic) hypothesis posits that solute clearance is convective and driven by active fluid transport from para-arterial to paravenous spaces though aquaporin-4 water channels in astrocyte endfeet...
November 3, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29078601/community-for-thoracoscopic-surgery
#16
REVIEW
Eunjue Yi, Sanghoon Jheon
Video-assisted thoracoscopic surgery (VATS) is a real game changer in thoracic surgery. Surgical environment for thoracic surgeon have become complicated more and more as the techniques and technology have been advanced. No single surgeon can stand alone in this rapid changing circumstance. Surgeons need to meet, talk together, and discuss what they have done. There may be no perfect answers, however, surgeon will get to know which way is better. Although the chosen one could be different from each of them, surgeons can debates and conclude the consensus...
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29072055/diagnostic-challenges-in-prostate-cancer-and-68ga-psma-pet-imaging-a-game-changer
#17
Maseeh uz Zaman, Nosheen Fatima, Areeba Zaman, Mahwsih Sajid, Unaiza Zaman, Sidra Zaman
Prostate cancer (PC) is the most frequent solid tumor in men and the third most common cause of cancer mortality among men in developed countries. Current imaging modalities like ultrasound (US), computerized tomography (CT), magnetic resonance imaging (MRI) and choline based positron emission (PET) tracing have disappointing sensitivity for detection of nodal metastasis and small tumor recurrence. This poses a diagnostic challenge in staging of intermediate to high risk PC and restaging of patients with biochemical recurrence (PSA >0...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29064844/the-smurf-transition-new-insights-on-ageing-from-end-of-life-studies-in-animal-models
#18
Michael Rera, Céline Vallot, Christel Lefrançois
PURPOSE OF REVIEW: Over the past 5 years, many articles were published concerning the prediction of high risk of mortality in apparently healthy adults, echoing the first description in 2011 of the Smurf phenotype, a harbinger of natural death in drosophila. RECENT FINDINGS: These recent findings suggest that the end-of-life is molecularly and physiologically highly stereotyped, evolutionarily conserved and predictable. SUMMARY: Taken altogether, these results from independent teams using multiple organisms including humans draw the lines of future directions in ageing research...
October 23, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29040736/social-media-in-medicine-a-game-changer
#19
Matthew P M Graham-Brown, Tom Oates
No abstract text is available yet for this article.
November 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28986509/why-targeting-psma-is-a-game-changer-in-the-management-of-prostate-cancer-%C3%A2-a-urologist-s-point-of-view
#20
Nicholas M Donin, Robert Reiter
Prostate-specific membrane antigen (PSMA), is a transmembrane glycoprotein that is highly expressed on prostate adenocarcinomas, exhibits only limited expression in benign and extra-prostatic tissues, and thus represents an ideal target for the diagnosis and management of prostate cancer. Since its discovery over 30 years ago, significant effort has been made to develop clinical technology targeting PSMA. The last 5 years have seen an explosion of development of new agents targeting PSMA for diagnostic and therapeutic use...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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