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https://www.readbyqxmd.com/read/28638166/will-real-time-monitoring-technology-be-a-game-changer-for-perfusion-safety
#1
Linda B Mongero
No abstract text is available yet for this article.
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28630366/a-game-changer-for-hereditary-cancer-patients
#2
Brit Cooper-Jones, Katelyn Verstraten
No abstract text is available yet for this article.
June 19, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28611985/adaptation-through-collaboration-developing-novel-platforms-to-advance-the-delivery-of-advanced-therapies-to-patients
#3
REVIEW
Magdalini Papadaki
For the nascent field of advanced therapies, collaboration will be a game-changer, turning scientific progress that was once unimaginable into transformative medical practice. Despite promise for lifelong management and even cure of disease, skepticism remains about the feasibility of their delivery to patients, fueling investment risks. With the potential for long-term effectiveness in need of frequent reassessment, current approaches to predict real-life drug performance bear little relevance, necessitating novel and iterative schemes to monitoring the benefit-risk profiles throughout the life span of advanced therapies...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28601415/brain-autoimmunity-and-intestinal-microbiota-100-trillion-game-changers
#4
REVIEW
Hartmut Wekerle
T cells play a critical role in autoimmune diseases in the brain, particularly in multiple sclerosis (MS). Since T cells are normally prevented from crossing the blood-brain barrier (BBB), autoimmunity requires prior activation of naturally occurring autoreactive T cells in peripheral tissue. Recently, a critical role for the microbiota in this activation process has emerged. Here, we review the role of gut-associated lymphoid tissues (GALT) as a major site for the phenotypic changes that allow the migration of autoreactive T cells to the brain...
June 7, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/28590032/epithelial-mesenchymal-transition-in-cancer-metastasis-through-the-lymphatic-system
#5
REVIEW
Mikael C Karlsson, Santiago F Gonzalez, Josefin Welin, Jonas Fuxe
It was already in the 18th century when the French surgeon Le Dran first noted that breast cancer patients with spread of tumor cells to their axillary lymph nodes had a drastically worse prognosis than patients without spread (leDran et al., 1752). Since then, metastatic spread of cancer cells to regional lymph nodes has been established as the most important prognostic factor in many types of cancer (Carter et al., 1989; Elston and Ellis, 1991). However, despite its clinical importance, lymph metastasis remains an underexplored area of tumor biology...
June 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28585344/a-game-changer-a-multifunctional-perovskite-exhibiting-giant-ferroelectricity-and-narrow-bandgap-with-potential-application-in-a-truly-monolithic-multienergy-harvester-or-sensor
#6
Yang Bai, Pavel Tofel, Jaakko Palosaari, Heli Jantunen, Jari Juuti
An ABO3 -type perovskite solid-solution, (K0.5 Na0.5 )NbO3 (KNN) doped with 2 mol% Ba(Ni0.5 Nb0.5 )O3-δ (BNNO) is reported. Such a composition yields a much narrower bandgap (≈1.6 eV) compared to the parental composition-pure KNN-and other widely used piezoelectric and pyroelectric materials (e.g., Pb(Zr,Ti)O3 , BaTiO3 ). Meanwhile, it exhibits the same large piezoelectric coefficient as that of KNN (≈100 pC N(-1) ) and a much larger pyroelectric coefficient (≈130 µC m(-2) K(-1) ) compared to the previously reported narrow-bandgap material (KNbO3 )1-x -BNNOx ...
June 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28579359/evolution-in-treatment-strategy-for-metastatic-spine-disease-presently-evolving-modalities
#7
REVIEW
N Kumar, R Malhotra, A S Zaw, K Maharajan, N Naresh, A Kumar, B Vellayappan
The advent of minimally invasive surgery (MIS) in the surgical management armamentarium and stereotactic radiosurgery in the domain of radiotherapy, has led to a major evolution in treatment of metastatic spine disease (MSD). We reviewed the recent literature to discuss evolution from open to MIS approaches in MSD and the concurrent evolution in radiotherapy. This will provide a sound base for further development and understanding of treatment paradigms in MSD. Literature review showed that evolution of surgery can be traced from inappropriate open surgery (i...
May 17, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28574731/why-gene-editors-like-crispr-cas-may-be-a-game-changer-for-neuroweapons
#8
Diane DiEuliis, James Giordano
This year marks the Eighth Review Conference (RevCon) of the Biological Toxins and Weapons Convention (BWC). At the same time, ongoing international efforts to further and more deeply investigate the brain's complex neuronal circuitry are creating unprecedented capabilities to both understand and control neurological processes of thought, emotion, and behavior. These advances have tremendous promise for human health, but the potential for their misuse has also been noted, with most discussions centering on research and development of agents that are addressed by existing BWC and Chemical Weapons Convention (CWC) proscriptions...
May 2017: Health Security
https://www.readbyqxmd.com/read/28558662/evaluation-of-gene-xpert-for-routine-diagnosis-of-hiv-associated-tuberculosis-in-nigeria-a-prospective-cohort-study
#9
Maxwell Oluwole Akanbi, Chad Achenbach, Babafemi Taiwo, John Idoko, Agatha Ani, Yetunde Isa, Oche Agbaji, Christiana Ukoli, Patrick Akande, Mamoudou Maiga, Robert Leo Murphy
BACKGROUND: Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of Xpert on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB in Nigeria. METHODS: Adults with HIV being evaluated for pulmonary TB (PTB) were consecutively enrolled into the study cohort. At baseline, expectorated sputa were examined using Xpert and smear microscopy for Mycobacterium tuberculosis (MTB) and acid fast bacilli, respectively...
May 30, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28555551/-economic-crisis-and-portuguese-national-health-service-physicians-findings-from-a-descriptive-study-of-their-perceptions-and-reactions-from-health-care-units-in-the-greater-lisbon-area
#10
Inês Rego, Giuliano Russo, Luzia Gonçalves, Julian Perelman, Pedro Pita Barros
INTRODUCTION: In Europe, scant scientific evidence exists on the impact of economic crisis on physicians. This study aims at understanding the adjustments made by public sector physicians to the changing conditions, and their perceptions on the market for medical services in the Lisbon metropolitan area. MATERIAL AND METHODS: A random sample of 484 physicians from São José Hospital and health center groups in Cascais and Amadora, to explore their perceptions of the economic crisis, and the changes brought to their workload...
April 28, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28537437/-it-is-definitely-a-game-changer-a-qualitative-study-of-experiences-with-in-home-overnight-closed-loop-technology-among-adults-with-type-1-diabetes
#11
Christel Hendrieckx, Lucinda A Poole, Amin Sharifi, Dilshani Jayawardene, Margaret M Loh, Jodie C Horsburgh, Leon A Bach, Peter G Colman, Kavita Kumareswaran, Alicia J Jenkins, Richard J MacIsaac, Glenn M Ward, Benyamin Grosman, Anirban Roy, David N O'Neal, Jane Speight
BACKGROUND: This qualitative study explored trial participants' experiences of four nights of in-home closed loop. METHODS: Sixteen adults with type 1 diabetes, who completed a randomized crossover trial, were interviewed after four consecutive nights of closed-loop. Interviews were audio recorded, transcribed, and analyzed with a coding framework developed to identify the main themes. RESULTS: Participants had a mean age of 42 ± 10 years, nine were women; mean diabetes duration was 27 ± 7 years, and all were using insulin pumps...
May 24, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28534757/tissue-engineering-and-regenerative-medicine-the-promise-the-challenges-the-future
#12
Leslie Mertz
Medical researchers increasingly regard tissue engineering and regenerative medicine as potential game changers when it comes to repairing damage from disease or injury and restoring function. To understand the progress made and challenges ahead for this combined field, IEEE Pulse sought out two experts: David F. Williams, former global president (2012-2015) of the Tissue Engineering and Regenerative Medicine International Society, and Roderic I. Pettigrew, founding director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) [1]...
May 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28501982/smartphone-applications-for-hypertension-management-a-potential-game-changer-that-needs-more-control
#13
REVIEW
Gianfranco Parati, Camilla Torlasco, Stefano Omboni, Dario Pellegrini
PURPOSE OF THE REVIEW: This review article will summarize available data on mobile applications for the management of hypertension, by highlighting their potential for clinical use, the current limitations and the yet pending issues to be addressed in future studies. RECENT FINDINGS: The number of available applications related to arterial hypertension and their usage by smartphone owners is constantly increasing. However, most applications lack standardization and scientific validation, and security flaws could be an important, yet still underrated, issue...
June 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28433975/absolute-benefits-of-empagliflozin-in-type-2-diabetes-a-game-changer
#14
EDITORIAL
Cyrus R Kumana, Kathryn C B Tan, Bernard M Y Cheung
No abstract text is available yet for this article.
April 22, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28413187/noninvasive-fractional-flow-reserve-derived-from-coronary-computed-tomography-angiography%C3%A3-is-this-just-another-new-diagnostic-test-or-the-long-awaited-game-changer
#15
Hiromasa Otake, Charles A Taylor, Hitoshi Matsuo, Nobuhiro Tanaka, Takashi Akasaka
Despite the clinical importance of ischemia evaluation, obtaining fractional flow reserve (FFR) value has, heretofore, only been available during invasive cardiac catheterization. Although there is a clear linkage between morphology and physiology, a significant gap still exists. FFR derived from coronary computed tomography angiography (FFRCT) is a novel method of quantifying the hemodynamic significance of coronary artery stenoses by translating morphological information into hemodynamic data. Improved diagnostic performance of FFRCThas been repeatedly demonstrated in comparison with coronary computed tomography angiography alone with an invasive FFR reference standard...
April 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28377276/encapsulation-systems-for-the-delivery-of-hydrophilic-nutraceuticals-food-application
#16
REVIEW
N P Aditya, Yadira Gonzalez Espinosa, Ian T Norton
Increased health risk associated with the sedentary life style is forcing the food manufacturers to look for food products with specific or general health benefits e.g. beverages enriched with nutraceuticals like catechin, curcumin rutin. Compounds like polyphenols, flavonoids, vitamins are the good choice of bioactive compounds that can be used to fortify the food products to enhance their functionality. However due to low stability and bioavailability of these bioactives (both hydrophobic and hydrophilic) within the heterogeneous food microstructure and in the Gastro Intestinal Tract (GIT), it becomes extremely difficult to pass on the real health benefits to the consumers...
April 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28363738/ex-vivo-lung-perfusion-the-makings-of-a-game-changer
#17
EDITORIAL
J W Awori Hayanga
No abstract text is available yet for this article.
March 7, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28320774/3d-bioprint-me-a-socioethical-view-of-bioprinting-human-organs-and-tissues
#18
Niki Vermeulen, Gill Haddow, Tirion Seymour, Alan Faulkner-Jones, Wenmiao Shu
In this article, we review the extant social science and ethical literature on three-dimensional (3D) bioprinting. 3D bioprinting has the potential to be a 'game-changer', printing human organs on demand, no longer necessitating the need for living or deceased human donation or animal transplantation. Although the technology is not yet at the level required to bioprint an entire organ, 3D bioprinting may have a variety of other mid-term and short-term benefits that also have positive ethical consequences, for example, creating alternatives to animal testing, filling a therapeutic need for minors and avoiding species boundary crossing...
March 20, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28287846/will-the-first-approved-automated-insulin-delivery-system-be-a-game-changer-in-type-1-diabetes-management
#19
Jessica R Castle
No abstract text is available yet for this article.
March 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28249663/immunotherapy-in-squamous-cell-skin-carcinoma-a-game-changer
#20
Sravanthi Ravulapati, Cerena Leung, Nishant Poddar, Yifan Tu
No abstract text is available yet for this article.
February 26, 2017: American Journal of Medicine
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