Arun B Dutta, Daniel S Lank, Roza K Przanowska, Piotr Przanowski, Lixin Wang, Bao Nguyen, Ninad M Walavalkar, Fabiana M Duarte, Michael J Guertin
Adipocytes contribute to metabolic disorders such as obesity, diabetes, and atherosclerosis. Prior characterizations of the transcriptional network driving adipogenesis overlook transiently acting transcription factors (TFs), genes, and regulatory elements that are essential for proper differentiation. Moreover, traditional gene regulatory networks provide neither mechanistic details about individual RE-gene relationships nor temporal information needed to define a regulatory hierarchy that prioritizes key regulatory factors...
February 21, 2023: Genome Research