Yuxiao Liu, Weitong Su, Zhengshuai Liu, Zhimin Hu, Jiaxin Shen, Zengpeng Zheng, Dong Ding, Wei Huang, Wenjing Li, Genxiang Cai, Shuang Wei, Ni Li, Xia Fang, Hong Li, Jun Qin, Haibing Zhang, Yichuan Xiao, Yan Bi, Aoyuan Cui, Chunxiang Zhang, Yu Li
Chronic adipose tissue inflammation accompanied by macrophage accumulation and activation is implicated in the pathogenesis of insulin resistance and type 2 diabetes in humans. The transcriptional coregulator CREBZF is a key factor in hepatic metabolism, yet its role in modulating adipose tissue inflammation and type 2 diabetes remains elusive. The present study demonstrates that overnutrition-induced CREBZF links adipose tissue macrophage (ATM) proinflammatory activation to insulin resistance. CREBZF deficiency in macrophages, not in neutrophils, attenuates macrophage infiltration in adipose, proinflammatory activation, and hyperglycemia in diet-induced insulin-resistant mice...
January 29, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)