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https://www.readbyqxmd.com/read/28714407/update-of-standard-practices-for-new-method-validation-in-forensic-toxicology
#1
Sarah M R Wille, Wim Coucke, Thierry De Baere, Frank T Peters
: International agreement concerning validation guidelines is important as reporting reliable analytical data is the backbone of forensic bioanalytical research and applications. Guidelines such as those provided by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), the German speaking Gesellschaft für Toxikologie und Forensische Chemie (GTFCH) and the Scientific Working Group of Forensic Toxicology (SWGTOX) provide a standard for fundamental validation parameters such as selectivity, matrix effects, method limits, calibration, accuracy and stability, as well as other parameters such as carryover, dilution integrity and incurred sample reanalysis...
July 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28707513/cross-cultural-adaptation-and-validation-of-the-danish-10-item-connor-davidson-resilience-scale-among-hospital-staff
#2
Line Skjødt Lauridsen, Morten Vejs Willert, Anita Eskildsen, David Høyrup Christiansen
OBJECTIVES: The 10-item Connor-Davidson Resilience Scale (CD-RISC 10) is a brief instrument measuring resilience in adults. The scale has shown sound psychometric properties in different populations and cultures. Our objectives were to cross-culturally adapt the CD-RISC 10 into Danish and to establish the psychometric properties of the Danish version in terms of internal consistency, construct validity and longitudinal validity. METHODS: The CD-RISC 10 was translated using established guidelines...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28704137/uruguayan-secondary-school-students-speak-up-about-tobacco-results-from-focus-group-discussions-in-and-around-montevideo
#3
Erin Peterson, Melissa Harrell, Andrew Springer, José Medina, Lucía Martinez, Cheryl Perry, Diego Estol
This qualitative research study investigated intrapersonal, interpersonal, and environmental factors that shape young adolescent tobacco use behaviors in Uruguay. Focus groups were conducted in the summer of 2012 and fall of 2013 in four secondary schools in Montevideo, Uruguay, including two private schools and two public schools. A total of four focus groups were led in each school, composed of 4-6 students each, 16 focus groups in total. Data analysis utilized NVivo software and included deductive and inductive content analysis...
July 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28700284/prevalence-of-financial-fraud-and-scams-among-older-adults-in-the-united-states-a-systematic-review-and-meta-analysis
#4
David Burnes, Charles R Henderson, Christine Sheppard, Rebecca Zhao, Karl Pillemer, Mark S Lachs
BACKGROUND: The financial exploitation of older adults was recently recognized by the Centers for Disease Control and Prevention as a serious public health problem. Knowledge of the prevalence of elder financial exploitation is mostly limited to the category of financial abuse, which occurs in relationships involving an expectation of trust. Little is known about the other major category of elder financial exploitation-elder financial fraud and scams, which is perpetrated by strangers...
August 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28697926/health-literacy-and-health-outcomes-in-very-old-patients-with-heart-failure
#5
Rocío León-González, Esther García-Esquinas, Emilio Paredes-Galán, Ana Isabel Ferrero-Martínez, José-Luis González-Guerrero, Mercedes Hornillos-Calvo, Rocío Menéndez-Colino, Ivett Torres-Torres, María Concepción Galán, Marta Torrente-Carballido, Mayte Olzcoz-Chiva, Carlos Rodríguez-Pascual, Fernando Rodríguez-Artalejo
INTRODUCTION AND OBJECTIVES: Health literacy (HL) has been associated with lower mortality in heart failure (HF). However, the results of previous studies may not be generalizable because the research was conducted in relatively young and highly-educated patients in United States settings. This study assessed the association of HL with disease knowledge, self-care, and all-cause mortality among very old patients, with a very low educational level. METHODS: This prospective study was performed in 556 patients (mean age, 85 years), with high comorbidity, admitted for HF to the geriatric acute-care unit of 6 hospitals in Spain...
July 8, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28697697/postfocal-downstep-in-german
#6
Frank Kügler, Caroline Féry
This article is a follow-up study of Féry and Kügler (2008. Pitch accent scaling on given, new and focused constituents in German. Journal of Phonetics, 36, 680-703). It reports on an experiment of the F0 height of potential pitch accents in the postfocal region of German sentences and addresses in this way an aspect of the influence of information structure on the intonation of sentences that was left open in the previous article. The results of the experiment showed that, when several constituents are located in this position, they are often in a downstep relation, but are rarely upstepped...
June 2017: Language and Speech
https://www.readbyqxmd.com/read/28696621/-genomic-medicine-the-challenges-of-information-in-clinical-practice
#7
Idris Guessous, Vincent Mooser, Jacques Fellay, Murielle Bochud, Umberto Simeoni, Sheila Unger, Gérard Waeber, Jacques Cornuz
The genomic revolution lifts up several potential opportunities in predictive and preventive medicine. Yet, genomic medicine opportunities can lead to clinical utility only if challenges that come with it are understood, anticipated, and faced. This review discusses the challenges that genomic medicine raises for the patients and their physicians, the general population, study participants and investigators. The article presents a program of genomic consultation in general internal medicine in the French-speaking part of Switzerland (MedOmics) that aims to address these challenges in order to optimize the clinical opportunities offered by genomic medicine...
November 2, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28689518/colon-cancer-screening-is-it-time-yet
#8
EDITORIAL
Hadi Bhurgri, Sami Samiullah
The month of March is dedicated to Colon Cancer Awareness. Worldwide, colorectal cancer (CRC) incidence has been on the rise. It is currently the third most common cancer in men (746,000 cases, 10.0% of the total) and the second in women (614,000 cases, 9.2% of the total).1 Arecent meta-analysis reported a 61% risk reduction in CRC incidence with colonoscopy.2 Unlike screening programs for breast and prostate cancers, not only has CRC screening reduced mortality from colon cancer and detected early CRC, it has also decreased the incidence of CRC through detection and removal of pre-cancerous lesions...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28688761/long-non-coding-rna-gm4419-promotes-trauma-induced-astrocyte-apoptosis-by-targeting-tumor-necrosis-factor-%C3%AE
#9
Yunhu Yu, Fang Cao, Qishan Ran, Fei Wang
Traumatic brain injury (TBI) remains a life-threatening disease. Accumulating evidences have showed that neuroinflammatory response is a critical biological event in the progression of TBI induced astrocyte damage. However, the exact mechanisms are not well understood. In this study, we demonstrated that long non-coding RNA (lncRNA) Gm4419 promoted trauma-induced astrocyte apoptosis by up-regulating the expression of inflammatory cytokine tumor necrosis factor α (TNF-α). We observed that Gm4419 was aberrantly induced after injury on astroglial cells in vitro...
July 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28683760/quality-of-multiple-sclerosis-out-patient-health-care-services-with-focus-on-patient-reported-experiences
#10
Anne Marit Solheim, Åse Mygland, Unn Ljøstad
BACKGROUND: To investigate multiple sclerosis (MS) patients' satisfaction with out-patient follow-up in a general neurological hospital department. Patients with definite MS living in Vest-Agder county, Norway were invited to answer a questionnaire comprising one question regarding overall satisfaction, and 24 questions regarding demographics, disease characteristics, and experiences with different aspects of the health care services. RESULTS: Out of 330 invited patients, 159 responded (48%)...
July 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28676121/developing-nurse-medication-safety-training-in-a-health-partnership-in-mozambique-using-behavioural-science
#11
Eleanor Rose Bull, Corina Mason, Fonseca Domingos Junior, Luana Vendramel Santos, Abigail Scott, Debo Ademokun, Zeferina Simião, Wingi Manzungu Oliver, Fernando Francisco Joaquim, Sarah M Cavanagh
BACKGROUND: Globally, safe and effective medication administration relies on nurses being able to apply strong drug calculation skills in their real-life practice, in the face of stressors and distractions. These may be especially prevalent for nurses in low-income countries such as Mozambique and Continuing Professional Development post-registration may be important. This study aimed to 1) explore the initial impact of an international health partnership's work to develop a drug calculation workshop for nurses in Beira, Mozambique and 2) reflect upon the role of health psychologists in helping educators apply behavioural science to the training content and evaluation...
July 4, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28671906/does-one-size-fit-all-assessing-the-need-for-organizational-second-victim-support-programs
#12
Hanan H Edrees, Albert W Wu
OBJECTIVE: Second victims are health care providers who are emotionally traumatized after experiencing an unanticipated patient's adverse event. To support second victims, organizations can provide a dedicated support program for their workers. The aim of this study was to assess the extent of the second victim problem in acute care hospitals in the state of Maryland, the availability of emotional support services, and the need for organizational support programs. METHODS: In-depth, semistructured interviews were conducted with 43 patient safety representatives from 38 acute hospitals in Maryland...
June 30, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28670474/on-the-bridge-over-the-translational-valley-of-death-interview-with-per-i-arvidsson
#13
Per I Arvidsson
Per I Arvidsson speaks to Francesca Lake, Managing Editor: Per received his PhD in organic chemistry from Gothenburg University (Sweden) in 1999, where he continued as a lecturer for a short time. Following 2 years at the ETH Zurich (Switzerland) as a postdoctoral fellow, he went on to establish an independent research group at the Department of Biochemistry and Organic Chemistry at Uppsala University (Sweden). In 2006, he joined AstraZeneca R&D Södertälje (Sweden). After 1-year in-house training for future leaders in drug discovery and development, he became team leader in Medicinal Chemistry in 2007...
June 2017: Future Science OA
https://www.readbyqxmd.com/read/28664331/benefit-of-the-ultrazoom-beamforming-technology-in-noise-in-cochlear-implant-users
#14
Isabelle Mosnier, Nathalie Mathias, Jonathan Flament, Dorith Amar, Amelie Liagre-Callies, Stephanie Borel, Emmanuèle Ambert-Dahan, Olivier Sterkers, Daniele Bernardeschi
The objectives of the study were to demonstrate the audiological and subjective benefits of the adaptive UltraZoom beamforming technology available in the Naída CI Q70 sound processor, in cochlear-implanted adults upgraded from a previous generation sound processor. Thirty-four adults aged between 21 and 89 years (mean 53 ± 19) were prospectively included. Nine subjects were unilaterally implanted, 11 bilaterally and 14 were bimodal users. The mean duration of cochlear implant use was 7 years (range 5-15 years)...
June 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28662709/interval-follow-up-of-a-4-day-pilot-program-to-implement-the-who-surgical-safety-checklist-at-a-congolese-hospital
#15
Michelle C White, Jennifer Peterschmidt, James Callahan, J Edward Fitzgerald, Kristin L Close
BACKGROUND: The World Health Organisation Surgical Safety Checklist (SSC) improves surgical outcomes and the research question is no longer 'does the SSC work?' but, 'how to make the SSC work?' Evidence for implementation strategies in low-income countries is sparse and existing strategies are heavily based on long-term external support. Short but effective implementation programs are required if widespread scale up is to be achieved. We designed and delivered a four-day pilot SSC training course at a single hospital centre in the Republic of Congo, and evaluated the implementation after one year...
June 29, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28660649/neonatal-bcg-has-no-effect-on-allergic-sensitization-and-suspected-food-allergy-until-13-months
#16
Lisbeth Marianne Thøstesen, Henrik Fomsgaard Kjaer, Gitte Thybo Pihl, Thomas Nørrelykke Nissen, Nina Marie Birk, Jesper Kjaergaard, Aksel Karl Georg Jensen, Peter Aaby, Annette Wind Olesen, Lone Graff Stensballe, Dorthe Lisbeth Jeppesen, Christine Stabell Benn, Poul-Erik Kofoed
BACKGROUND: Vaccination with Bacillus Calmette-Guérin (BCG) is used in many countries as protection against tuberculosis. Studies have suggested that BCG may also have non-specific effects, reducing non-tuberculosis mortality, morbidity, and atopic manifestations. In this study we evaluated the effect of neonatal BCG vaccination on allergic sensitization and suspected food allergy at 13 months of age. METHODS: The Danish Calmette Study was conducted from 2012-2015 at three Danish hospitals...
June 29, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28660617/exploring-the-core-of-crew-resource-management-course-speak-up-or-stay-silent
#17
Roar Espevik, Evelyn Rose Saus, Olav Kjellvold Olsen
The Norwegian Costal Express travels 24/7 along a coast considered as one of the most dangerous littoral areas of the world. It is crucial for safe voyage to speak up when one of the crewmembers discovers a discrepancy or vital new information to the passage that needs to be shared and acted upon. Crew resource management courses are intended to increase safety and we suggest that the key is to enhance the ability to speak up. Watch keepers valued a 4-h course intended to enhance the ability to speak up and improve listening skills as highly relevant (89%) and educational (69%)...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28659259/initial-progress-toward-development-of-a-voice-based-computer-delivered-motivational-intervention-for-heavy-drinking-college-students-an-experimental-study
#18
Christopher W Kahler, William J Lechner, James MacGlashan, Tyler B Wray, Michael L Littman
BACKGROUND: Computer-delivered interventions have been shown to be effective in reducing alcohol consumption in heavy drinking college students. However, these computer-delivered interventions rely on mouse, keyboard, or touchscreen responses for interactions between the users and the computer-delivered intervention. The principles of motivational interviewing suggest that in-person interventions may be effective, in part, because they encourage individuals to think through and speak aloud their motivations for changing a health behavior, which current computer-delivered interventions do not allow...
June 28, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28658973/the-relation-between-physical-activity-and-cognitive-change-in-older-latinos
#19
Shannon Halloway, JoEllen Wilbur, Michael E Schoeny, Lisa L Barnes
Cognitive impairment in older Latinos is of concern due to the rapid growth of this population and their increased risk for dementia due to chronic disease. Evidence, primarily from studies of non-Latino Whites, suggests that physical activity (PA) may reduce cognitive decline. Few longitudinal studies have included older Latinos, objective measures of PA, or neurocognitive tests that assess domains of cognition. The purpose of this longitudinal study was to explore the relationship between changes in PA and cognitive decline in older Latinos over an average of 5 years...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28658044/the-modified-low-back-pain-disability-questionnaire-reliability-validity-and-responsiveness-of-a-dutch-language-version
#20
Lenie Denteneer, Gaetane Stassijns, Steven Truijen, Willem De Herthogh, Jill Meirte, Kristiaan Deckers, Ulrike Van Daele
STUDY DESIGN: Cross sectional study OBJECTIVE.: The goal of this study is to translate the English version of the Modified Low Back Pain Disability Questionnaire (MDQ) into a Dutch version and investigate its clinimetric properties for patients with nonspecific chronic low back pain (CLBP). SUMMARY OF BACKGROUND DATA: Fritz et al (2001) developed a modified version of the Oswestry Disability Questionnaire (ODI) to assess functional status and named it the MDQ. In this version, a question regarding employment and homemaking ability was substituted for the question related to sex life...
June 27, 2017: Spine
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