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https://www.readbyqxmd.com/read/28448778/economic-impact-of-above-label-dosing-with-etanercept-adalimumab-or-ustekinumab-in-patients-with-psoriasis
#1
Steven R Feldman, Yang Zhao, Huanxue Zhou, Vivian Herrera, Haijun Tian, Yunfeng Li
BACKGROUND: Patients with moderate-to-severe psoriasis may be treated with above-label doses of biologics in an attempt to optimize outcomes. Dose escalation will have an effect on the cost of treatment. OBJECTIVE: To examine costs related to above-label use of etanercept, adalimumab, and ustekinumab among patients with moderate-to-severe psoriasis. METHODS: A retrospective study was performed using a large U.S. claims database. Patients were included in the study if they were aged ≥ 18 years with a diagnosis of psoriasis (excluding psoriatic arthritis) and had at least 1 medication fill for etanercept, adalimumab, or ustekinumab between January 1, 2011, and June 30, 2012...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448555/socio-demographic-disparities-in-the-utilisation-of-general-practice-services-for-australian-children-results-from-a-nationally-representative-longitudinal-study
#2
Lixin Ou, Jack Chen, Ken Hillman
OBJECTIVE: This study aimed to investigate the pattern of general practice services utilization for Australian children and to examine socio-demographic disparities in general practitioner (GP) visits. METHODS: We used the linked data from the nationally representative Longitudinal Study of Australian Children (LSAC) and the Medicare Australia claims data record. We used survey negative binomial and logistic regression to examine the socio-demographic factors associated with the utilisation of general practice services...
2017: PloS One
https://www.readbyqxmd.com/read/28448358/can-health-care-professionals-do-anything-about-gun-violence
#3
Roxanne Nelson
Experts say yes, but providers must speak up-and take action.
May 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28442609/speaking-up-about-traditional-and-professionalism-related-patient-safety-threats-a-national-survey-of-interns-and-residents
#4
William Martinez, Lisa Soleymani Lehmann, Eric J Thomas, Jason M Etchegaray, Julia T Shelburne, Gerald B Hickson, Donald W Brady, Anneliese M Schleyer, Jennifer A Best, Natalie B May, Sigall K Bell
BACKGROUND: Open communication between healthcare professionals about care concerns, also known as 'speaking up', is essential to patient safety. OBJECTIVE: Compare interns' and residents' experiences, attitudes and factors associated with speaking up about traditional versus professionalism-related safety threats. DESIGN: Anonymous, cross-sectional survey. SETTING: Six US academic medical centres, 2013-2014. PARTICIPANTS: 1800 medical and surgical interns and residents (47% responded)...
April 25, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28437520/academic-performance-motor-function-and-behavior-11-years-after-neonatal-caffeine-citrate-therapy-for-apnea-of-prematurity-an-11-year-follow-up-of-the-cap-randomized-clinical-trial
#5
Barbara Schmidt, Robin S Roberts, Peter J Anderson, Elizabeth V Asztalos, Lorrie Costantini, Peter G Davis, Deborah Dewey, Judy D'Ilario, Lex W Doyle, Ruth E Grunau, Diane Moddemann, Harvey Nelson, Arne Ohlsson, Alfonso Solimano, Win Tin
Importance: Caffeine citrate therapy for apnea of prematurity reduces the rates of bronchopulmonary dysplasia, severe retinopathy, and neurodevelopmental disability at 18 months and may improve motor function at 5 years. Objective: To evaluate whether neonatal caffeine therapy is associated with improved functional outcomes 11 years later. Design, Setting, and Participants: A follow-up study was conducted at 14 academic hospitals in Canada, Australia, and the United Kingdom from May 7, 2011, to May 27, 2016, of English- or French-speaking children who had been enrolled in the randomized, placebo-controlled Caffeine for Apnea of Prematurity trial between October 11, 1999, and October 22, 2004...
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28433450/a-retrospective-cohort-study-of-concomitant-ipsilateral-extra-capsular-and-intra-capsular-fractures-of-the-proximal-femur-are-they-casual-findings-or-an-undervalued-reality
#6
Miquel Videla-Cés, José-Miguel Sales-Pérez, Joan Girós-Torres, Rubén Sánchez-Navés, Sebastián Videla
BACKGROUND: Fractures of the proximal femur constitute a major public health problem, with an annual incidence in Spain of 7.6 cases per 1000 inhabitants over 65 years of age. Hip fractures are frequent in elderly patients, related to osteoporosis and with low energy trauma, which means that they can be considered a geriatric syndrome. Simultaneous ipsilateral extra- and intra-articular hip fractures are considered as very rare are, and generally speaking, classified as extra- or intra-capsular fractures...
April 13, 2017: Injury
https://www.readbyqxmd.com/read/28426949/agarra-agarran-evidence-of-early-comprehension-of-subject-verb-agreement-in-spanish
#7
Nayeli Gonzalez-Gomez, Lisa Hsin, Isabelle Barrière, Thierry Nazzi, Géraldine Legendre
Studies across many languages (e.g., Dutch, English, Farsi, Spanish, Xhosa) have failed to show early acquisition of subject-verb (SV) agreement, whereas recent studies on French reveal acquisition by 30months of age. Using a similar procedure as in previous French studies, the current study evaluated whether earlier comprehension of SV agreement in (Mexican) Spanish can be revealed when task demands are lowered. Two experiments using a touch-screen pointing task tested comprehension of SV agreement by monolingual Spanish-speaking children growing up in Mexico City between about 3 and 5years of age...
April 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28421331/two-troubling-trends-in-the-conversation-over-whether-clinical-ethics-consultants-have-ethics-expertise
#8
Abram Brummett, Christopher J Ostertag
In a recent issue of the Journal of Medicine and Philosophy, several scholars wrote on the topic of ethics expertise in clinical ethics consultation. The articles in this issue exemplified what we consider to be two troubling trends in the quest to articulate a unique expertise for clinical ethicists. The first trend, exemplified in the work of Lisa Rasmussen, is an attempt to define a role for clinical ethicists that denies they have ethics expertise. Rasmussen cites the dependence of ethical expertise on irresolvable meta-ethical debates as the reason for this move...
April 18, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28409441/isolated-rectal-cancer-surgery-a-2007-2014-population-study-based-on-a-large-administrative-database
#9
Mario Saia, Alessandra Buja, Domenico Mantoan, Gino Sartor, Ferdinando Agresta, Vincenzo Baldo
Rectal resection is technically one of the most demanding laparoscopic procedures, requiring additional training and expertise of both surgeons and institutions. The literature has shown that laparoscopic procedures can be appropriate for the treatment of rectal cancer (RC), in terms of safety, outcome and efficiency, but results may not always be directly transferable to the general population. This study aimed to investigate the use of laparoscopic rectal cancer resections in a north-eastern Italian region (the Veneto) and to see how the characteristics of patients and hospitals are associated with the use of laparoscopy...
April 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28407720/cross-cultural-adaptation-and-validation-of-the-arabic-version-of-the-knee-outcome-survey-activities-for-daily-living-scale
#10
Fawzi F Bouzubar, Sameera H Aljadi, Naser M Alotaibi, James J Irrgang
PURPOSE: The purpose of this study is to cross-culturally adapt the Knee Outcome Survey-Activities of Daily Living Scale into Arabic and to assess its psychometric properties (internal consistency, reliability, validity, and responsiveness) in patients with knee disorders. METHODS: The cross-cultural adaptation process for the Knee Outcome Survey-Activities of Daily Living Scale into Arabic was performed consistent with the published guidelines. The psychometric properties of this Arabic version were then evaluated...
April 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28397033/a-grassroots-community-dialogue-on-the-ethics-of-the-care-of-people-with-autism-and-their-families-the-stony-brook-guidelines
#11
Stephen G Post, John Pomeroy, Carla Keirns, Virginia Isaacs Cover, Michael Leverett Dorn
The increased recognition and reported prevalence of autism spectrum disorders (ASD) combined with the associated societal and clinical impact call for a broad grassroots community-based dialogue on treatment related ethical and social issues. In these Stony Brook Guidelines, which were developed during a full year of community dialogue (2010-2011) with affected individuals, families, and professionals in the field, we identify and discuss topics of paramount concern to the ASD constituency: treatment goals and happiness, distributive justice, managing the desperate hopes for a cure, sibling responsibilities, intimacy and sex, diagnostic ethics, and research ethics...
April 10, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28390614/coblation-of-suprastomal-granulomas-in-tracheostomy-dependent-children
#12
C Scott Brown, Marisa A Ryan, Vaibhav H Ramprasad, Anatoli F Karas, Eileen M Raynor
OBJECTIVE: Suprastomal granulomas pose a persistent challenge for tracheostomy-dependent children. They can limit phonation, cause difficulty with tracheostomy tube changes and prevent decannulation. We describe the use of the coblator for radiofrequency plasma ablation of suprastomal granulomas in five consecutive children from September 2012 to January 2016. METHOD: Retrospective case series at a tertiary medical center. RESULTS: The suprastomal granuloma could be removed with the coblator in all 5 cases...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28386242/evaluation-of-a-psychological-intervention-for-patients-with-chronic-pain-in-primary-care
#13
Francisco J Cano-García, María Del Carmen González-Ortega, Susana Sanduvete-Chaves, Salvador Chacón-Moscoso, Roberto Moreno-Borrego
According to evidence from recent decades, multicomponent programs of psychological intervention in people with chronic pain have reached the highest levels of efficacy. However, there are still many questions left to answer since efficacy has mainly been shown among upper-middle class patients in English-speaking countries and in controlled studies, with expert professionals guiding the intervention and with a limited number of domains of painful experience evaluated. For this study, a program of multicomponent psychological intervention was implemented: (a) based on techniques with empirical evidence, but developed in Spain; (b) at a public primary care center; (c) among patients with limited financial resources and lower education; (d) by a novice psychologist; and (e) evaluating all domains of painful experience using the instruments recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28385912/translating-concerns-into-action-a-detailed-qualitative-evaluation-of-an-interdisciplinary-intervention-on-medical-wards
#14
Samuel Pannick, Stephanie Archer, Maximillian J Johnston, Iain Beveridge, Susannah Jane Long, Thanos Athanasiou, Nick Sevdalis
OBJECTIVES: To understand how frontline reports of day-to-day care failings might be better translated into improvement. DESIGN: Qualitative evaluation of an interdisciplinary team intervention capitalising on the frontline experience of care delivery. Prospective clinical team surveillance (PCTS) involved structured interdisciplinary briefings to capture challenges in care delivery, facilitated organisational escalation of the issues they identified, and feedback...
April 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28383387/worldwide-abortion-rates-and-access-to-contraception-speak-up-against-the-global-gag-rule
#15
Nancy C Chescheir
No abstract text is available yet for this article.
April 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28379935/simulation-fellowship-programs-an-international-survey-of-program-directors
#16
Brenda Natal, Demian Szyld, Scott Pasichow, Zia Bismilla, Jonathan Pirie, Adam Cheng
PURPOSE: To report on the evolution of simulation-based training (SBT) by identifying the composition and infrastructure of existing simulation fellowship programs, describing the current training practices, disclosing existing program barriers, and highlighting opportunities for standardization. METHOD: Investigators conducted a cross-sectional survey study among English-speaking simulation fellowship program directors (September 2014-September 2015). They identified fellowships through academic/institutional Web sites, peer-reviewed literature, Web-based search engines, and snowball sampling...
April 4, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28377417/cervical-infection-with-cutaneous-beta-and-mucosal-alpha-papillomaviruses
#17
Laura Sichero, Mariam El-Zein, Emily M Nunes, Silvaneide Ferreira, Eduardo L Franco, Luisa L Villa
BACKGROUND: Alpha-human papillomavirus (α-HPV) play a causal role in cervical cancer but little is known about the epidemiology of genital Beta-HPV infection. METHODS: We used Luminex and polymerase chain reaction (PCR) hybridization to detect β- and α-HPVs prevalence at enrolment and 12-months follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiological correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytological abnormalities...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28370737/experiences-of-going-to-court-witnesses-with-intellectual-disabilities-and-their-carers-speak-up
#18
Tessy Beckene, Rachel Forrester-Jones, Glynis H Murphy
BACKGROUND: People with intellectual disabilities are more vulnerable to sexual abuse and are more disadvantaged in the criminal justice system than the general population. However, little is known about the experiences of people with intellectual disabilities who have allegedly been victims of sexual abuse and also been witnesses in court. MATERIALS AND METHODS: This study used semi-structured interviews and a Grounded Theory approach to examine the experiences of four people with intellectual disabilities and four carers/supporters who had all attended trials...
March 31, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28367748/conceptions-of-agency-and-constraint-for-hiv-positive-patients-and-healthcare-workers-to-support-long-term-engagement-with-antiretroviral-therapy-care-in-khayelitsha-south-africa
#19
Erin Stern, Christopher Colvin, Nobom Gxabagxaba, Charlotte Schutz, Rosie Burton, Graeme Meintjes
In the context of the optimism around antiretroviral therapy (ART) as prevention of HIV/AIDS, addressing the barriers to long-term ART adherence is critical. This is particularly important given the tendency to individualise or use a blame discourse when exploring why HIV-infected patients "fail" to adequately adhere to ART, and not sufficiently exploring contextual reasons for poor adherence that may require varying solutions. This study took place at three clinics and one hospital in Khayelitsha, South Africa, to document the contextual factors that challenged ART adherence in this community...
March 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28366345/young-child-and-maternal-sleep-in-the-middle-east
#20
Jodi A Mindell, Christina Lee, Avi Sadeh
BACKGROUND: This study aimed to characterize sleep patterns and sleep problems in a large sample of infants and toddlers (from birth to three years) and their mothers in Arabic-speaking families in the Middle East and compare the results to those living in predominantly Asian and predominantly Caucasian countries/regions. METHODS: Mothers of 669 young children (from Saudi Arabia, Egypt, Algeria, United Arab Emirates, Jordan, Morocco, Iraq, Kuwai, Oman, Palestinian territories, Libyan Arab Jamahiriya, Bahrain, Israel, and other Arab countries) completed an Internet-based expanded version of the Brief Infant Sleep Questionnaire, Daily Infant Mood Scale, and the Pittsburgh Sleep Quality Index...
April 2017: Sleep Medicine
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