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Ovarian hemangioma

Josef Finsterer, Marlies Frank
There are some indications that the prevalence of benign and malign neoplasms is increased in patients with a mitochondrial disorder (MID). This study aimed at calculating the prevalence of malign and benign neoplasms in MID patients compared to the general population. Among 103 adult patients with definite or probable MID 16 had a malignancy (15.5%) and 11 (10.7%) a benign neoplasm. Four patients had thyroid cancer, three patients had prostate cancer, two patients each colon cancer, or ovarian cancer, and one each lung cancer, basalioma, Paget carcinoma of the skin, Bowen disease, renal cancer, and urinary bladder cancer...
July 2016: Mitochondrion
Katayoun Ziari, Kamyab Alizadeh
Ovarian hemangiomas are benign and rare tumors of female genital tract with less than 60 reported cases in the literature. A 38- yr- old woman was admitted to Be'sat Hospital, Tehran, Iran in 2012, due to severe abdominal pain. Ultrasound evaluation revealed a 6 cm left ovarian cystic mass and serum tumor markers were normal. Then, left salpingo-oophorectomy was performed for the patient. Microscopic examination revealed a follicular cyst and an incidental cavernous hemangioma consisting thin-walled vascular channels filled with blood that lined with flatten endothelial cells...
2016: Iranian Journal of Pathology
D Metodiev, V Ivanova, B Omainikova, Tz Boshnakova
In 2009, Montgomery and Epstein coined the term "anastomosing hemangioma" for a newly described variant of capillary hemangioma with an unusual sinusoidal pattern, histologically mimicking angiosarcoma. The lesion was considered unique for genitourinary system with predilection to kidney but we found in the literature only 4 cases of this entity in ovaries. A 70-year-old woman presented with ultrasound visualized myometrial nodules and cystic formation of the right ovary, intraoperatively diagnosed as serous cystadenoma...
2015: Akusherstvo i Ginekologii︠a︡
Sun Suk Kim, Si Eun Han, Nam Kyung Lee, Kyung Un Choi, Jong Kil Joo, Dong Soo Suh, Heung Yeol Kim, Ki Hyung Kim
Ovarian hemangiomas are usually of the cavernous type, and are rarely encountered. A 73-year-old woman presented with lower abdominal discomfort. Subsequent physical examination depicted a palpable mass in the lower abdomen. Abdominopelvic computed tomography (CT) revealed a well-circumscribed mass with thin septa measuring 12.1 × 9.0 cm in the right ovary. Levels of the tumor markers cancer antigen (CA)-125 and CA 19-9 were within the normal range. At laparoscopy, the tumor was found to be confined to the right ovary and to have a smooth surface...
December 2015: Journal of Menopausal Medicine
Abbas Agaimy, Florian Haller
β-catenin (CTNNB1) is a key regulatory molecule of the Wnt signaling pathway, which is important for tissue homeostasis and regulation of cell proliferation, differentiation, and function. Abnormal stabilization and nuclear accumulation of β-catenin as a consequence of missense mutations or alternative molecular mechanisms occurs at a high frequency in a variety of epithelial cancers. In mesenchymal neoplasia, the role of β-catenin has been traditionally considered limited to desmoid-type fibromatosis. However, the spectrum of β-catenin-driven (β-catenin-altered) neoplasia of mesenchymal origin has been steadily widening to include, in addition to desmoid tumors, a variety of benign and intermediate-biology neoplasms of soft tissue (intranodal palisaded myofibroblastoma), head and neck (juvenile nasopharyngeal angiofibroma and sinonasal hemangiopericytoma/glomangiopericytoma), and ovarian (microcystic stromal tumor) origin...
January 2016: Advances in Anatomic Pathology
Masaharu Akiyama, Masayoshi Yamaoka, Yoko Mikami-Terao, Wataru Ohyama, Kentaro Yokoi, Yasuhiro Arakawa, Junko Takita, Hideaki Suzuki, Hisashi Yamada
Maffucci syndrome is a nonhereditary congenital disorder characterized by multiple enchondromas and with soft-tissue hemangiomas. Somatic mutations of the isocitrate dehydrogenase (IDH) gene have been detected in enchondroma and hemangioma tissue from patients with Maffucci syndrome. The rate of malignant transformation in Maffucci syndrome is high, with enchondromas transforming into chondrosarcomas and the development of secondary neoplasms, including pancreatic and hepatic adenocarcinoma, mesenchymal ovarian tumors, and brain tumors such as glioma...
December 2015: International Journal of Hematology
Sara O Vaz, Renato Pires, Luís M Pires, Isabel M Carreira, Rui Anjos, Paula Maciel, Luisa Mota-Vieira
BACKGROUND: The rearrangements of the 22q11.2 chromosomal region, most frequently deletions and duplications, have been known to be responsible for multiple congenital anomaly disorders. These rearrangements are implicated in syndromes that have some phenotypic resemblances. While the 22q11.2 deletion, also known as DiGeorge/Velocardiofacial syndrome, has common features that include cardiac abnormalities, thymic hypoplasia, characteristic face, hypocalcemia, cognitive delay, palatal defects, velopharyngeal insufficiency, and other malformations, the microduplication syndrome is largely undetected...
2015: BMC Pediatrics
Sedat Alpaslan Tuncel, Bekir Çaglı, Aslan Tekataş, Mehmet Yadigar Kırıcı, Ercüment Ünlü, Hakan Gençhellaç
OBJECTIVE: The aim of the present study was to determine the prevalence and reporting rate of incidental findings (IF) in adult outpatients undergoing lumbar magnetic resonance imaging (MRI). MATERIALS AND METHODS: Re-evaluation of a total of 1278 lumbar MRI images (collected from patients with a mean age of 50.5 years, range 16-91 years) captured between August 2010-August 2011 was done by a neuroradiologist and a musculoskeletal radiologist. IFs were classified according to organ or system (liver, gallbladder, kidney, bladder, uterus, ovary, lymph node, intestine and aorta)...
July 2015: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
John Kenneth Schoolmeester, Patricia T Greipp, Gary L Keeney, Robert A Soslow
Hemangiomas of the ovary are rare with a majority described as individual reports of unusual clinical presentations or morphologic findings. Both the expected and unexpected pathologic features of these tumors in the ovary are not well detailed. Therefore, we collected the largest series of ovarian hemangiomas to comprehensively define their clinicopathologic associations and examine the significance of hormone receptors in their pathogenesis. In addition, a novel EWSR1-NFATC1 fusion has recently been described in a case of hemangioma of bone...
September 2015: International Journal of Gynecological Pathology
Jie Yu, Ping Liang, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Mengjuan Mu, Yanmei Liu
OBJECTIVE: To investigate the feasibility, safety and efficacy of ultrasound-guided percutaneous microwave ablation (MWA) of splenic tumors. METHODS: Seven patients with 8 pathologically confirmed splenic tumors (including 2 metastases from the ovary and 4 from the lung, gastric adenocarcinoma, hepatocellular carcinoma, or rectal carcinoma; 1 hemangioma and 1 inflammatory pseudotumor) with sizes ranging from 1.3 to 6.2 cm (mean 3.1 ± 1.9 cm) were treated with MWA...
March 2015: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Tip Pongsuvareeyakul, Jongkolnee Settakorn, Jiraporn Khorana, Surapan Khunamornpong
BACKGROUND: Ovarian teratoma with predominant hemangiomatous component in pediatric patients is very rare and its presentation may mimic that of malignancy. CASE: A 2-year-old girl presented with proptosis of the right eye. A right ovarian mass was detected on the physical examination. The right orbital lesion was consistent with venolymphatic-type vascular malformation on magnetic resonance imaging. The abdominal computed tomographic scan revealed a solid ovarian mass that raised a suspicion for malignancy...
February 2015: Journal of Pediatric and Adolescent Gynecology
Hyun-Ji Choi, Hyun-Kyu Park, Woori Jo, Jae-Eun Ryu, Sungwoong Jang, Hee-Kyung Gu, Kyung-Sung Kim, Bong Jin Chung, Woo-Chan Son
Metamifop is a novel herbicide with as yet undetermined properties. To assess its carcinogenicity, metamifop was mixed into standard rodent chow and fed to male and female Wistar rats at doses of 10, 100 and 750ppm for 104weeks. The viability/mortality of these rats was not affected by treatment with metamifop. Treatment had no significant effects on clinical parameters, and food consumption. Males and females fed 750ppm of metamifop for 104weeks showed decreases in body weight and body weight gain. Histopathological examination revealed that treatment with metamifop reduced non-neoplastic findings (chronic progressive nephropathy, tubular basophilia, tubular casts, glomerulosclerosis, basophilic and clear cell foci, senile atrophy, and mesothelial hyperplasia) and reduced neoplastic findings (thymoma, pituitary adenoma, and mammary fibroadenoma and adenocarcinoma in females, and mesenteric lymph node hemangioma in males) compared with control groups...
November 2014: Regulatory Toxicology and Pharmacology: RTP
Chunsheng Li, Ann-Marie Chacko, Jia Hu, Kosei Hasegawa, Jennifer Swails, Luigi Grasso, Wafik S El-Deiry, Nicholas Nicolaides, Vladimir R Muzykantov, Chaitanya R Divgi, George Coukos
UNLABELLED: Tumor endothelial marker 1 (TEM1, endosialin) is a tumor vascular marker with significant diagnostic and therapeutic potential. However, in vivo small animal models to test affinity reagents specifically targeted to human (h)TEM1 are limited. We describe a new mouse tumor model where tumor vascular endothelial cells express hTEM1 protein. METHODS: Immortalized murine endothelial cells MS1 were engineered to express hTEM1 and firefly luciferase and were inoculated in nude mice either alone, to form hemangioma-like endothelial grafts, or admixed with ID8 ovarian tumor cells, to form chimeric endothelial-tumor cell grafts...
April 2014: Cancer Biology & Therapy
Mehmet Kefelı, Filiz Karagöz, Anais Malpica
Ovarian hemangioma is an uncommon ovarian tumor occurring in patients in different age groups. It is usually seen as small, asymptomatic mass, which is detected incidentally. On rare occasions, this type of tumor can be associated with other gynecological neoplasms. In this report, we present the clinicopathologic features of a case of ovarian hemangioma coexisting with multiple microscopic foci of dysgerminoma in a 10-year-old child. The patient presented with acute abdomen. Magnetic resonance imaging revealed a left ovarian mass and subsequent left salpingo-oophorectomy was performed...
2014: Türk Patoloji Dergisi
Richard Sheng Poe Huang, Michael Covinsky, Songlin Zhang
A 77-year-old female presented to the outpatient clinic with a six-month history of left lower quadrant abdominal fullness and pressure. Serum levels included free testosterone 3.8 pg/mL (normal 0-1.8 pg/mL) and testosterone 259 ng/dL (normal 3-41 ng/dL). Magnetic resonance imaging of the pelvis showed bilateral small ovarian cystic masses with marked, progressive enhancement, and restriction of diffusion. Laparoscopic bilateral salpingo-oophorectomy was performed and showed left and right ovarian hemorrhagic masses measuring 2...
2013: Annals of Clinical and Laboratory Science
Eralp Baser, Selcuk Erkilinc, Sertac Esin, Cihan Togrul, Ebru Biberoglu, Mujdegul Z Karaca, Tayfun Gungor, Nuri Danisman
OBJECTIVE: To outline and discuss the clinical features and outcomes of adnexal masses that were treated during cesarean delivery at a tertiary referral hospital located in Ankara, Turkey. METHODS: The operating room and pathology department databases for 2007-2012 were retrospectively reviewed for surgically managed adnexal masses during cesarean delivery. Clinicopathologic characteristics and maternal and neonatal outcomes were assessed. RESULTS: Adnexal masses occurred in 151 women (0...
November 2013: International Journal of Gynaecology and Obstetrics
Murthy S Anand, Shakila Shetty, Vijaya V Mysorekar, Rekha V Kumar
A 21 year old female presented with amenorrhea, hirsutism and change in voice along with an elevated serum β-HCG (human chorionic gonadotrophin) level and normal CA-125 level. Laparotomy revealed an enlarged right ovary measuring 6×5×1 cms with presence of an ovarian hemangioma along with stromal luteinization and HCG producing mononucleate as well as multinucleate cells of uncertain histogenesis on histopathological examination. Immunohistochemistry for inhibin and calretinin were positive in the luteinized component whereas β-HCG and Ki-67 were positive in the multinucleate cell component...
October 2012: Indian Journal of Pathology & Microbiology
Shin-Ichi Nakatsuka, Naoya Shigeta, Yojiro Ojima, Hayato Kimura, Teruaki Nagano, Kimihiko Ito
INTRODUCTION: Retroperitoneal cysts are a rare disease. Most retroperitoneal cysts of vascular origin have been reported as hemangiomas. However, according to the recent classification of vascular anomalies accepted by the International Society for Study of Vascular Anomalies (ISSVA), these previously reported retroperitoneal hemangiomas should rather have been classified as vascular malformations. CASE REPORT: A 65-year-old woman visited our hospital complaining of a sense of unexplained abdominal fullness...
October 2012: Archives of Gynecology and Obstetrics
Federico Selvaggi, Domenico Risio, Mathew Waku, Daniela Simo, Domenico Angelucci, Alberto D'Aulerio, Roberto Cotellese, Paolo Innocenti
Struma ovarii (SO) is a slow-growing ovarian neoplasm with thyroid tissue as its predominant component. It is an uncommon neoplasm, usually asymptomatic with an unknown risk of malignant transformation. Due to difficulties in assessing the rare biological nature and the discrepancies in the reported cases, a consensus on the appropriate treatment has not been definitively reached. A 50-year-old female was subjected to upper gut endoscopy which showed a 30-mm mass located in the gastric antrum, suggestive of mesenchimal tumor...
2012: World Journal of Surgical Oncology
D Fischerova
This Review documents examination techniques, sonographic features and clinical considerations in ultrasound assessment of gynecological tumors. The methodology of gynecological cancer staging, including assessment of local tumor extent, lymph nodes and distant metastases, is described. With increased technical quality, sonography has become an accurate staging method for early and advanced gynecological tumors. Other complementary imaging techniques, such as computed tomography and magnetic resonance imaging, can be used as an adjunct to ultrasound in specific cases, but are not essential to tumor staging if sonography is performed by a specialist in gynecological oncology...
September 2011: Ultrasound in Obstetrics & Gynecology
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