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Mesenchymal cell transplantation Chinese

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https://www.readbyqxmd.com/read/27724974/combined-transplantation-of-mesenchymal-stem-cells-and-endothelial-progenitor-cells-for-tissue-engineering-a-systematic-review-and-meta-analysis
#1
Kunming Sun, Zheng Zhou, Xinxin Ju, Yang Zhou, Jiaojiao Lan, Dongdong Chen, Hongzhi Chen, Manli Liu, Lijuan Pang
BACKGROUND: Combined cell implantation has been widely applied in tissue engineering in recent years. In this meta-analysis, we aimed to establish whether the combined transplantation of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) promotes angiogenesis and tissue repair, compared with transplantation of a single cell type, following tissue injury or during tissue regeneration. METHODS: The electronic databases PubMed, EMBASE, MEDLINE, Chinese Biomedical Literature, and China National Knowledge Infrastructure were searched in this systematic review and meta-analysis...
October 10, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27316395/mesenchymal-stem-cells-for-treating-autoimmune-diseases-the-chinese-experience-from-lab-to-clinics
#2
REVIEW
J Liang, D Wang, F Dominique, L Sun
Autoimmune diseases are a group of chronic inflammatory conditions diseases characterized by aberrant activation of the immune system involving either cells or antibodies directed against normal tissues. The current conventional strategies, notably corticosteroids and immunosuppressors, are responsible for high treatment-related morbidity and are still associated with significant disease and treatment-related mortality. Recently, experimental and clinical data has suggested that mesenchymal stem cell transplantation would be a promising therapy strategy for the treatment of autoimmune diseases...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27122663/combined-mesenchymal-stem-cell-transplantation-and-interleukin-1-receptor-antagonism-after-partial-hepatectomy
#3
Jian-Feng Sang, Xiao-Lei Shi, Bing Han, Xu Huang, Tao Huang, Hao-Zhen Ren, Yi-Tao Ding
AIM: To study the therapeutic effects of mesenchymal stem cells (MSCs) and an interleukin-1 receptor antagonist (IL-1Ra) in acute liver failure. METHODS: Chinese experimental miniature swine (15 ± 3 kg, 5-8 mo) were obtained from the Laboratory Animal Centre of the Affiliated Drum Tower Hospital of Nanjing University Medical School. Acute liver failure was induced via 85% hepatectomy, and animals were treated by MSC transplantation combined with IL-1Ra injection...
April 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26667804/atorvastatin-treatment-improves-effects-of-implanted-mesenchymal-stem-cells-meta-analysis-of-animal-models-with-acute-myocardial-infarction
#4
Guo Dai, Qing Xu, Rong Luo, Jianfang Gao, Hui Chen, Yun Deng, Yongqing Li, Yuequn Wang, Wuzhou Yuan, Xiushan Wu
BACKGROUND: Previous studies reported that Atorvastatin (ATOR) can improve the efficacy of Mesenchymal stem cells (MSCs) transplantation after acute myocardial infarction (AMI). However, the results of those studies were inconsistent. To clarify the beneficial effects of atorvastatin added to the cell therapy with MSCs in animal model of acute myocardial infarction (AMI), we performed a systematic review and meta-analysis of case-control studies. METHODS: Searches were performed using the PubMed database, the Excerpta Medica Database (Embase), the Science Citation Index, the China National Knowledge Information database, the Wanfang database, and the Chinese Scientific and Technological Journal Database (VIP database)...
2015: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/26221250/icariin-stimulates-the-proliferation-of-rat-bone-mesenchymal-stem-cells-via-erk-and-p38-mapk-signaling
#5
Shuyan Qin, Wei Zhou, Shaoying Liu, Puxiang Chen, Hongjin Wu
Bone mesenchymal stem cells (BMSCs) are able to differentiate into multi types of lineages, so they have been widely applied in the stem cell transplantation. The BMSCs are usually needed to be expanded before transplantation due to their limited content in bone marrow. It has recently been reported that Icariin (ICA), a major constituent of flavonoids from the Chinese medical herb Epimedium brevicornum Maxim, promotes the proliferation of various types of differentiated cells. However, whether ICA can enhance BMSCs proliferation and the possible underlying mechanisms are still unknown...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25811171/meta-analysis-of-the-effect-of-mesenchymal-stem-cell-transplantation-on-vascular-remodeling-after-carotid-balloon-injury-in-animal-models
#6
Xinxin Ju, Hong Zou, Kejian Liu, Juncang Duan, Shugang Li, Zheng Zhou, Yan Qi, Jin Zhao, Jianming Hu, Lianghai Wang, Wei Jia, Yutao Wei, Yixun Wang, Wenjie Zhang, Lijuan Pang, Feng Li
AIM: A meta-analysis was conducted to assess the efficacy of mesenchymal stem cell (MSC) transplantation in small animal coronary vessels after balloon injury, to provide data for the design of future pre-clinical experiments and human clinical trials. METHODS: The search strategy included the PubMed, EMBASE, Chinese Biomedical Literature (CBM), and China National Knowledge Infrastructure (CKNI) databases. The endpoint was the ratio of vascular neointima/media (I/M)...
2015: PloS One
https://www.readbyqxmd.com/read/25152138/-the-consensus-of-allogeneic-hematopoietic-transplantation-for-hematological-diseases-in-china-2014-indication-conditioning-regimen-and-donor-selection
#7
(no author information available yet)
No abstract text is available yet for this article.
August 2014: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/25119864/allogeneic-mesenchymal-stem-cell-transplantation-for-lupus-nephritis-patients-refractory-to-conventional-therapy
#8
Fei Gu, Dandan Wang, Huayong Zhang, Xuebing Feng, Gary S Gilkeson, Songtao Shi, Lingyun Sun
Allogeneic mesenchymal stem cell transplantation (MSCT) has been shown to be clinically efficacious in the treatment of various autoimmune diseases. Here, we analyzed the role of allogeneic MSCT to induce renal remission in patients with active and refractory lupus nephritis (LN). This is an open-label and single-center clinical trial conducted from 2007 to 2010 in which 81 Chinese patients with active and refractory LN were enrolled. Allogeneic bone marrow- or umbilical cord-derived mesenchymal stem cells (MSCs) were administered intravenously at the dose of 1 million cells per kilogram of bodyweight...
November 2014: Clinical Rheumatology
https://www.readbyqxmd.com/read/25063290/effect-of-rougan-huaqian-granules-combined-with-human-mesenchymal-stem-cell-transplantation-on-liver-fibrosis-in-cirrhosis-rats
#9
Zhen-Chang Wang, Shan Yang, Jing-Jing Huang, Song-Lin Chen, Quan-Qiang Li, Yuan Li
OBJECTIVE: To observe the effect of Rougan Huaqian granules combined with human mesenchymal stem cell (hMSC) transplantation on the liver fibrosis in carbon tetrachloride-induced cirrhosis rats. METHODS: Sixty SD rats were randomly divided into five groups. The rats in control group received intraperitoneal injection of saline, while those in model control group, treatment group A, group B and group C received intraperitoneal injection of carbon tetrachloride oily solution to induce liver cirrhosis within 8 weeks...
July 2014: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/24861835/advances-in-mesenchymal-stem-cells-combined-with-traditional-chinese-medicine-therapy-for-liver-fibrosis
#10
REVIEW
Shu Dong, Shi-Bing Su
Liver fibrosis is a primary cause of liver cirrhosis, and even hepatocarcinoma. Recently, the usage of mesenchymal stem cells (MSCs) has been investigated to improve liver fibrosis. It has been reported that the differentiation, proliferation and migration of MSCs can be regulated by traditional Chinese medicine treatment; however, the mechanisms are still unclear. In this article, the authors review the characteristics of MSCs such as multidirectional differentiation and homing, and its application in animal experiments and clinical trials...
May 2014: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/24817389/current-status-of-cell-mediated-regenerative-therapies-for-human-spinal-cord-injury
#11
REVIEW
Tongming Zhu, Qisheng Tang, Huasong Gao, Yiwen Shen, Luping Chen, Jianhong Zhu
During the past decade, significant advances have been made in refinements for regenerative therapies following human spinal cord injury (SCI). Positive results have been achieved with different types of cells in various clinical studies of SCI. In this review, we summarize recently-completed clinical trials using cell-mediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells. Specifically, clinical studies published in Chinese journals are included. These studies show that current transplantation therapies are relatively safe, and have provided varying degrees of neurological recovery...
August 2014: Neuroscience Bulletin
https://www.readbyqxmd.com/read/24759263/a-preliminary-evaluation-of-efficacy-and-safety-of-wharton-s-jelly-mesenchymal-stem-cell-transplantation-in-patients-with-type-2-diabetes-mellitus
#12
Xuebin Liu, Pei Zheng, Xiaodong Wang, Guanghui Dai, Hongbin Cheng, Zan Zhang, Rongrong Hua, Xinxin Niu, Jing Shi, Yihua An
INTRODUCTION: Stem cell therapy has recently been introduced to treat patients with type 2 diabetes mellitus (T2DM). However, no data are available on the efficacy and safety of allogeneic Wharton's Jelly-derived mesenchymal stem cell (WJ-MSC) transplantation in patients with T2DM. Here we performed a non-placebo controlled prospective phase I/II study to determine efficacy and safety of WJ-MSC transplantation in T2DM. METHODS: Twenty-two patients with T2DM were enrolled and received WJ-MSC transplantation through one intravenous injection and one intrapancreatic endovascular injection (catheterization)...
2014: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/24690752/a-meta-analysis-of-the-motion-function-through-the-therapy-of-spinal-cord-injury-with-intravenous-transplantation-of-bone-marrow-mesenchymal-stem-cells-in-rats
#13
Duo Zhang, Xijing He
BACKGROUND: To compare the efficacy of the therapy of spinal cord injury with intravenous transplantation of bone marrow mesenchymal stem cells (BMSCs) by Meta-analysis. METHODS: Studies of the BBB scores after intravenous transplantation of BMSCs were searched out from Pubmed, SCI, Cochrane Library, Chinese journal full-text database, China Biology Medicinedisc and Wanfang data-base and analyzed by Review Manager 5.2.5. RESULTS: Nine randomized controlled animal trials were selected with 235 rats enrolled...
2014: PloS One
https://www.readbyqxmd.com/read/24447475/-effects-of-the-chinese-herbal-extract-songyou-yin-on-the-residual-hepatocellular-carcinoma-after-chemotherapy-in-nude-mice
#14
Wei Xiong, Zhao-you Tang, Zheng-gang Ren, Xiu-yan Huang, Qing-an Jia, Xiao-ying Xie, Hu-jia Shen
OBJECTIVE: To investigate the effects of a Chinese herbal extract Songyou Yin on residual hepatocellular carcinoma after chemotherapy in nude mice and the relevant mechanisms. METHODS: Orthotopic nude mouse models bearing residual hepatocellular carcinoma after chemotherapy was established using human liver carcinoma MHCC97L cells. Three different doses of Songyon Yin (2.1 g/kg, 4.2 g/kg and 8.4 g/kg) were administered to the mice in the trial groups by intragastric gavage, respectively...
November 2013: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/24095254/the-effect-of-the-coumarin-like-derivative-osthole-on-the-osteogenic-properties-of-human-periodontal-ligament-and-jaw-bone-marrow-mesenchymal-stem-cell-sheets
#15
Li-Na Gao, Ying An, Ming Lei, Bei Li, Hao Yang, Hong Lu, Fa-Ming Chen, Yan Jin
Cell sheet engineering is a scaffold-free delivery concept that has been shown to improve mesenchymal stem cell-mediated regeneration of injured or pathologically damaged periodontal tissues in preclinical studies and several clinical trials. However, the best strategy for cell sheet production remains to be identified. The aim of this study was to investigate the biological effects of osthole, a coumarin-like derivative extracted from Chinese herbs, on the cell sheet formation and osteogenic properties of human periodontal ligament stem cells (PDLSCs) and jaw bone marrow mesenchymal stem cells (JBMMSCs)...
December 2013: Biomaterials
https://www.readbyqxmd.com/read/24081026/a-surgical-technique-for-homogenous-renal-distribution-of-substances-in-rats
#16
Marina Gabriela Monteiro Carvalho Mori da Cunha, Diego Vilibaldo Beckmann, Marianne Sylvia Carlon, Silvia Zia, Ney Luis Pippi, Alexandre Mazzanti, Anke Van der Perren, Jan Deprest, Jaan Toelen
Intra-arterial injection of mesenchymal stem cells has been proven to result in a superior nephroprotection compared to intravenous injection. This avoids initial passage through filter organs such as the lung, liver and spleen. The aim of the present study was to investigate whether suprarenal aortic delivery results in a homogenous distribution to both kidneys. Chinese ink was used to evaluate the renal distribution pattern for the comparison of two retrograde intra-aortic injection methods. In the first, the aorta caudal to the renal branches was temporarily clamped and Chinese ink was injected at the level of the renal arteries...
2013: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/24021796/-a-novel-treatment-regimen-for-acute-liver-failure-based-on-a-combination-of-mesenchymal-stem-cells-transplantation-and-il-lra-loaded-chitosan-nanoparticles
#17
Jiang-Qiang Xiao, Xiao-Lei Shi, Jia-Jun Tan, Ling Zhang, Qian Xu, Yi-Tao Ding
OBJECTIVE: To evaluate whether a combination therapy using allogeneic mesenchymal stem cell (MSC) transplantation and interleukin-1 receptor antagonist (IL-1Ra) chitosan nanoparticles is more robust than MSC transplantation alone for treating acute liver failure and to investigate the mechanisms of the improved therapeutic effect using a swine model system. METHODS: IL-1Ra-loaded nanoparticles were made of lactosylated chitosan-FITC using the electrostatic spray method and analyzed by enzyme-linked immunosorbent assay...
April 2013: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/23916885/administration-of-il-1ra-chitosan-nanoparticles-enhances-the-therapeutic-efficacy-of-mesenchymal-stem-cell-transplantation-in-acute-liver-failure
#18
Jiang-qiang Xiao, Xiao-lei Shi, Hu-cheng Ma, Jia-jun Tan, Lin-zhang, Qian Xu, Yi-tao Ding
BACKGROUND AND AIMS: To investigate the synergistic effect of IL-1Ra administration and stem cell transplantation in swine suffering from acute liver failure (ALF), to elucidate the mechanism of IL-1Ra activity and to demonstrate mesenchymal stem cell (MSC) transplantation as a potential treatment for ALF. METHODS: Thirty-five Chinese experimental mini-swine were divided into five groups randomly. Group A (n = 7) is the control group and all swine were injected with saline via portal veins...
July 2013: Archives of Medical Research
https://www.readbyqxmd.com/read/23569345/effect-evaluation-of-interleukin-1-receptor-antagonist-nanoparticles-for-mesenchymal-stem-cell-transplantation
#19
RANDOMIZED CONTROLLED TRIAL
Xiao-Lei Shi, Wei Zhu, Jia-Jun Tan, Jiang-Qiang Xiao, Lin Zhang, Qian Xu, Zheng-Liang Ma, Yi-Tao Ding
AIM: To study the efficacy of marrow mesenchymal stem cells (MSCs) transplantation combined with interleukin-1 receptor antagonist (IL-1Ra) for acute liver failure (ALF). METHODS: Chinese experimental miniature swine were randomly divided into four groups (n = 7), and all animals were given D-galactosamine (D-gal) to induce ALF. Group A animals were then injected with 40 mL saline via the portal vein 24 h after D-gal induction; Group B animals were injected with 2 mg/kg IL-1Ra via the ear vein 18 h, 2 d and 4 d after D-gal induction; Group C received approximately 1 × 10(8) green fluorescence protein (GFP)-labeled MSCs (GFP-MSCs) suspended in 40 mL normal saline via the portal vein 24 h after D-gal induction; Group D animals were injected with 2 mg/kg IL-1Ra via the ear vein 18 h after D-gal induction, MSCs transplantation was then carried out at 24 h after D-gal induction, and finally 2 mg/kg IL-1Ra was injected via the ear vein 1 d and 3 d after surgery as before...
March 28, 2013: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/23019965/-progress-of-treating-hormonal-avascular-necrosis-of-the-femoral-head-by-chinese-medicine-and-transplant-of-human-bone-marrow-mesenchymal-stem-cells
#20
Jian Cheng, Tao Yuan, Yong Ma
No abstract text is available yet for this article.
July 2012: Chinese Journal of Integrated Traditional and Western Medicine
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