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Mesenchymal cell transplantation lupus

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https://www.readbyqxmd.com/read/27924862/mesenchymal-stem-cell-transplantation-can-restore-lupus-disease-associated-mirna-expression-and-th1-th2-ratios-in-a-murine-model-of-sle
#1
Eun Wha Choi, MinJae Lee, Ji Woo Song, Il Seob Shin, Sung Joo Kim
C3.MRL-Fas(lpr)/J mice spontaneously develop high titers of anti-dsDNA, mild glomerular nephritis, and severe lymphoproliferation symptoms. This study aimed to compare the effects of long-term serial administration of human adipose tissue-derived mesenchymal stem cells (ASCs), and cyclophosphamide treatment in C3.MRL-Fas(lpr)/J mice using a murine SLE model. C3.MRL-Fas(lpr)/J mice were divided into saline (C), cyclophosphamide (Y), and ASC (H) treatment groups. Background-matched control C3H mice treated with saline (N) were also compared...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27721835/mesenchymal-stem-cell-based-therapy-for-kidney-disease-a-review-of-clinical-evidence
#2
REVIEW
Anna Julie Peired, Alessandro Sisti, Paola Romagnani
Mesenchymal stem cells form a population of self-renewing, multipotent cells that can be isolated from several tissues. Multiple preclinical studies have demonstrated that the administration of exogenous MSC could prevent renal injury and could promote renal recovery through a series of complex mechanisms, in particular via immunomodulation of the immune system and release of paracrine factors and microvesicles. Due to their therapeutic potentials, MSC are being evaluated as a possible player in treatment of human kidney disease, and an increasing number of clinical trials to assess the safety, feasibility, and efficacy of MSC-based therapy in various kidney diseases have been proposed...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27578578/-plasma-from-patients-with-systemic-lupus-erythematosus-inhibits-suppressive-activity-of-mesenchymal-stem-cells-against-lupus-b-lymphocytes
#3
Ying-Jie Nie, Li-Mei Luo, Yan Zha, Li Sun, Ji Luo, Run-Sang Pan, Xiao-Bin Tian
OBJECTIVE: To investigate whether plasma from patients with systemic lupus erythematosus (SLE) inhibits the suppressive effects of mesenchymal stem cells (MSCs) on lupus B lymphocytes. METHODS: MSCs isolated and expanded from the bone marrow of healthy donors were co-cultured with B cells purified from the peripheral blood of SLE patients in the presence of fetal bovine serum or pooled plasma from SLE patients, and the proliferation and maturation of the B lymphocytes were analyzed...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27558022/establishing-a-tree-shrew-model-of-systemic-lupus-erythematosus-and-cell-transplantation-treatment
#4
Guang-Ping Ruan, Xiang Yao, Ju-Fen Liu, Jie He, Zi-An Li, Jian-Yong Yang, Rong-Qing Pang, Xing-Hua Pan
BACKGROUND: The establishment of a tree shrew model for systemic lupus erythematosus (SLE) provides a new method to evaluate the pathogenesis of autoimmune diseases. METHODS: Eighty tree shrews were randomly divided into four groups receiving either an intraperitoneal injection of pristane, lipopolysaccharide (LPS), or pristane and LPS, or no injection. Three weeks after injection, the SLE model tree shrews were divided into the model group and the treatment group...
August 24, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27270729/long-term-safety-of-umbilical-cord-mesenchymal-stem-cells-transplantation-for-systemic-lupus-erythematosus-a-6-year-follow-up-study
#5
Dandan Wang, Lingying Niu, Xuebing Feng, Xinran Yuan, Shengnan Zhao, Huayong Zhang, Jun Liang, Cheng Zhao, Hong Wang, Bingzhu Hua, Lingyun Sun
The aim of this study is to assess the long-term safety of allogeneic umbilical cord mesenchymal stem cells (UC MSCs) transplantation for patients with refractory systemic lupus erythematosus (SLE). Nine SLE patients, who were refractory to steroid and immunosuppressive drugs treatment and underwent MSCs transplantation in 2009, were enrolled. One million allogeneic UC MSCs per kilogram of body weight were infused intravenously at days 0 and 7. The possible adverse events, including immediately after MSCs infusions, as well as the long-term safety profiles were observed...
June 7, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27174201/generation-and-characterization-of-integration-free-induced-pluripotent-stem-cells-from-patients-with-autoimmune-disease
#6
Mi-Young Son, Mi-Ok Lee, Hyejin Jeon, Binna Seol, Jung Hwa Kim, Jae-Suk Chang, Yee Sook Cho
Autoimmune diseases (AIDs), a heterogeneous group of immune-mediated disorders, are a major and growing health problem. Although AIDs are currently treated primarily with anti-inflammatory and immunosuppressive drugs, the use of stem cell transplantation in patients with AIDs is becoming increasingly common. However, stem cell transplantation therapy has limitations, including a shortage of available stem cells and immune rejection of cells from nonautologous sources. Induced pluripotent stem cell (iPSC) technology, which allows the generation of patient-specific pluripotent stem cells, could offer an alternative source for clinical applications of stem cell therapies in AID patients...
2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27048648/rapamycin-reverses-the-senescent-phenotype-and-improves-immunoregulation-of-mesenchymal-stem-cells-from-mrl-lpr-mice-and-systemic-lupus-erythematosus-patients-through-inhibition-of-the-mtor-signaling-pathway
#7
Zhifeng Gu, Wei Tan, Juan Ji, Guijian Feng, Yan Meng, Zhanyun Da, Genkai Guo, Yunfei Xia, Xinhang Zhu, Guixiu Shi, Chun Cheng
We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE. The aim of this study was to investigate the effects of rapamycin (RAPA) on the senescences and immunoregulatory ability of MSCs of MRL/lpr mice and SLE patients and the underlying mechanisms. Cell morphology, senescence associated β-galactosidase (SA-β-gal) staining, F-actin staining were used to detect the senescence of cells. BM-MSCs and purified CD4+ T cells were co-cultured indirectly...
May 2016: Aging
https://www.readbyqxmd.com/read/26525582/update-on-mesenchymal-stem-cell-based-therapy-in-lupus-and-scleroderma
#8
REVIEW
Audrey Cras, Dominique Farge, Thierry Carmoi, Jean-Jacques Lataillade, Dan Dan Wang, Lingyun Sun
Current systemic therapies are rarely curative for patients with severe life-threatening forms of autoimmune diseases (ADs). During the past 15 years, autologous hematopoietic stem cell transplantation has been demonstrated to cure some patients with severe AD refractory to all other available therapies. As a consequence, ADs such as lupus and scleroderma have become an emerging indication for cell therapy. Multipotent mesenchymal stem cells (MSCs), isolated from bone marrow and other sites, display specific immunomodulation and anti-inflammatory properties and appear as ideal tools to treat such diseases...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26445510/beyond-hit-and-run-stem-cells-leave-a-lasting-memory
#9
COMMENT
Kelvin S Ng, Thomas M Kuncewicz, Jeffrey M Karp
While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigenetic changes conferred by secretory action of the MSCs.
October 6, 2015: Cell Metabolism
https://www.readbyqxmd.com/read/26435067/the-regulation-of-the-treg-th17-balance-by-mesenchymal-stem-cells-in-human-systemic-lupus-erythematosus
#10
Dandan Wang, Saisai Huang, Xinran Yuan, Jun Liang, Renju Xu, Genhong Yao, Xuebing Feng, Lingyun Sun
BACKGROUND AND OBJECTIVE: Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) have shown immunoregulation of various immune cells. The aim of this study was to investigate the mechanism of UC MSCs in the regulation of peripheral regulatory T cells (Treg) and T helper 17 (Th17) cells in patients with systemic lupus erythematosus (SLE). METHODS: Thirty patients with active SLE, refractory to conventional therapies, were given UC MSCs infusions. The percentages of peripheral blood CD4+CD25+Foxp3+ regulatory T cells (Treg) and CD3+CD8-IL17A+ Th17 cells and the mean fluorescence intensities (MFI) of Foxp3 and IL-17 were measured at 1 week, 1 month, 3 months, 6 months, and 12 months after MSCs transplantation (MSCT)...
October 5, 2015: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/26377835/comparative-efficacies-of-long-term-serial-transplantation-of-syngeneic-allogeneic-xenogeneic-or-ctla4ig-overproducing-xenogeneic-adipose-tissue-derived-mesenchymal-stem-cells-on-murine-systemic-lupus-erythematosus
#11
Eun Wha Choi, Hee Woo Lee, Il Seob Shin, Ji Hyun Park, Tae Won Yun, Hwa Young Youn, Sung-Joo Kim
Allogeneic and xenogeneic transplantation are suitable alternatives for treating patients with stem cell defects and autoimmune diseases. The purpose of this study was to compare the effects of long-term serial transplantation of adipose tissue-derived mesenchymal stem cells (ASCs) from (NZB × NZW) F1 mice (syngeneic), BALB/c mice (allogeneic), or humans (xenogeneic) on systemic lupus erythematosus (SLE). The effects of transplanting human ASCs overproducing CTLA4Ig (CTLA4Ig-hASC) were also compared. Animals were divided into five experimental groups, according to the transplanted cell type...
2016: Cell Transplantation
https://www.readbyqxmd.com/read/26365178/msc-transplantation-improves-osteopenia-via-epigenetic-regulation-of-notch-signaling-in-lupus
#12
Shiyu Liu, Dawei Liu, Chider Chen, Kazunori Hamamura, Alireza Moshaverinia, Ruili Yang, Yao Liu, Yan Jin, Songtao Shi
Mesenchymal stem cell transplantation (MSCT) has been used to treat human diseases, but the detailed mechanisms underlying its success are not fully understood. Here we show that MSCT rescues bone marrow MSC (BMMSC) function and ameliorates osteopenia in Fas-deficient-MRL/lpr mice. Mechanistically, we show that Fas deficiency causes failure of miR-29b release, thereby elevating intracellular miR-29b levels, and downregulates DNA methyltransferase 1 (Dnmt1) expression in MRL/lpr BMMSCs. This results in hypomethylation of the Notch1 promoter and activation of Notch signaling, in turn leading to impaired osteogenic differentiation...
October 6, 2015: Cell Metabolism
https://www.readbyqxmd.com/read/26209923/mesenchymal-stem-cells-promote-cd206-expression-and-phagocytic-activity-of-macrophages-through-il-6-in-systemic-lupus-erythematosus
#13
Wei Deng, Weiwei Chen, Zhuoya Zhang, Saisai Huang, Wei Kong, Yue Sun, Xiaojun Tang, Genhong Yao, Xuebing Feng, WanJun Chen, Lingyun Sun
Human umbilical cord-derived mesenchymal stem cells (UCMSCs) show therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in functional polarization and phagocytosis in macrophages has been suggested in the pathogenesis of SLE. We found that macrophages from B6.MRL-Fas(lpr) mice exhibited lower level of CD206, the marker for alternatively activated macrophage (AAM, also called M2). In addition, the phagocytic activity of B6.MRL-Fas(lpr) macrophages was also decreased. UCMSC transplantation improved the proportion of CD206(+) macrophages and their phagocytic activity in B6...
December 2015: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/26157021/-unknown-title
#14
Dandan Wang, Huayong Zhang, Jun Liang, Xia Li, Xuebing Feng, Hong Wang, Bingzhu Hua, Bujun Liu, Liwei Lu, Gary S Gilkeson, Richard M Silver, Wanjun Chen, Songtao Shi, Lingyun Sun
Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitors and are capable of differentiating into several tissues of mesenchymal origin. We have shown that bone marrow derived MSCs from both SLE patients and lupus prone MRL/lpr mice are defective structurally and functionally. Here we observe the long-term safety and efficacy of allogeneic MSC transplantation (MSCT) in treatment-resistant SLE patients. Eighty-seven patients with persistently active SLE who were refractory to standard treatment or had life-threatening visceral involvement were enrolled...
October 31, 2012: Cell Transplantation
https://www.readbyqxmd.com/read/26012584/transplantation-of-mesenchymal-stem-cells-ameliorates-secondary-osteoporosis-through-interleukin-17-impaired-functions-of-recipient-bone-marrow-mesenchymal-stem-cells-in-mrl-lpr-mice
#15
Lan Ma, Reona Aijima, Yoshihiro Hoshino, Haruyoshi Yamaza, Erika Tomoda, Yosuke Tanaka, Soichiro Sonoda, Guangtai Song, Wei Zhao, Kazuaki Nonaka, Songtao Shi, Takayoshi Yamaza
INTRODUCTION: Secondary osteoporosis is common in systemic lupus erythematosus and leads to a reduction in quality of life due to fragility fractures, even in patients with improvement of the primary disorder. Systemic transplantation of mesenchymal stem cells could ameliorate bone loss and autoimmune disorders in a MRL/lpr mouse systemic lupus erythematosus model, but the detailed therapeutic mechanism of bone regeneration is not fully understood. In this study, we transplanted human bone marrow mesenchymal stem cells (BMMSCs) and stem cells from exfoliated deciduous teeth (SHED) into MRL/lpr mice and explored their therapeutic mechanisms in secondary osteoporotic disorders of the systemic lupus erythematosus model mice...
May 27, 2015: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/25995969/delivering-oxidation-resistance-1-oxr1-to-mouse-kidney-by-genetic-modified-mesenchymal-stem-cells-exhibited-enhanced-protection-against-nephrotoxic-serum-induced-renal-injury-and-lupus-nephritis
#16
Yajuan Li, Wei Li, Chu Liu, Mei Yan, Indu Raman, Yong Du, Xiangdong Fang, Xin J Zhou, Chandra Mohan, Quan-Zhen Li
OBJECTIVE: To elucidate the role of oxidation resistance 1 (OXR1) gene. Oxidative stress plays a pivotal role in pathogenesis of immune-mediated nephritis. Recently we identified oxidation resistance 1 (OXR1) is conventionally expressed in eukaryotes and has an ability to prevent oxidative damage caused by various oxidative stresses. However the protective effect of OXR1 in immune-associated inflammatory response and oxidative damage is not clear and will be investigated in this study...
September 10, 2014: Journal of Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/25941899/transplantation-of-adipose-tissue-derived-mesenchymal-stem-cells-prevents-the-development-of-lupus-dermatitis
#17
Eun Wha Choi, Il Seob Shin, Ji Woo Song, Tae Won Yun, Jehoon Yang, Kyu-Sil Choi, Je Kyung Seong
MRL/lpr mice spontaneously develop high titers of anti-dsDNA antibodies and symptoms such as glomerular nephritis and organ weight gain. They also develop spontaneous skin inflammation similar to the cutaneous lesions common in human lupus erythematosus. This study aimed to compare the effects of long-term serial administration of human adipose tissue-derived mesenchymal stem cells (ASCs), CTLA4Ig-overexpressing ASCs, and cyclophosphamide treatment in MRL/lpr mice. MRL/lpr mice were divided into saline (C), cyclophosphamide (Y), ASC early (E), ASC late (L), and CTLA4Ig-overexpressing ASC (CT) treatment groups...
September 1, 2015: Stem Cells and Development
https://www.readbyqxmd.com/read/25914407/combined-transplantation-of-autologous-hematopoietic-stem-cells-and-allogenic-mesenchymal-stem-cells-increases-t-regulatory-cells-in-systemic-lupus-erythematosus-with-refractory-lupus-nephritis-and-leukopenia
#18
Q Wang, S Qian, J Li, N Che, L Gu, Q Wang, Y Liu, H Mei
Autologous hematopoietic stem cell (HSC) and mesenchymal stem cell (MSC) transplantation is currently being evaluated as a novel treatment for autoimmune diseases, such as systemic lupus erythematosus (SLE). Here we report a case of autologous HSC transplantation combined with MSCs in a 25-year-old severe SLE patient with multiple life-threatening complications and refractory to conventional cyclophosphamide (CYC) therapy. After being pretreated with CYC, fludarabine and antithymocyte globulin, the patient was transplanted with autologous CD34+HSCs and MSCs by intravenous infusion...
October 2015: Lupus
https://www.readbyqxmd.com/read/25904587/-unknown-title
#19
Dandan Wang, Huayong Zhang, Jun Liang, Xia Li, Xuebing Feng, Hong Wang, Bingzhu Hua, Bujun Liu, Liwei Lu, Gary S Gilkeson, Richard M Silver, Wanjun Chen, Songtao Shi, Lingyun Sun
Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitors and are capable of differentiating into several tissues of mesenchymal origin. We have shown that bone marrow derived MSCs from both SLE patients and lupus prone MRL/lpr mice are defective structurally and functionally. Here we observe the long-term safety and efficacy of allogeneic MSC transplantation (MSCT) in treatment-resistant SLE patients. Eighty-seven patients with persistently active SLE who were refractory to standard treatment or had life-threatening visceral involvement were enrolled...
October 31, 2012: Cell Transplantation
https://www.readbyqxmd.com/read/25896297/stem-cell-therapies-for-systemic-lupus-erythematosus-current-progress-and-established-evidence
#20
REVIEW
Dandan Wang, Lingyun Sun
Systemic lupus erythematosus is a multisystem autoimmune disease that, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. In recent years, hematopoietic stem cells and, most recently, mesenchymal stem cells have been used to treat drug-resistant cases. Some progress was made, but there are still some issues to be resolved in the clinic.
June 2015: Expert Review of Clinical Immunology
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