Dandan Wang, Huayong Zhang, Mengshu Cao, Yu Tang, Jun Liang, Xuebing Feng, Hong Wang, Bingzhu Hua, Bujun Liu, Lingyun Sun
OBJECTIVE: To assess the safety and clinical efficacy of allogeneic mesenchymal stem cell transplantation (MSCT) in a small-scale pilot study with 10 patients with drug-resistant polymyositis (PM) or dermatomyositis (DM). METHODS: A single-arm trial involving 10 patients with DM/PM who were either refractory to standard treatment, or had severe systemic involvement. All patients consented and underwent allogeneic MSCT. Clinical and laboratory manifestations were compared before and after MSCT...
July 2011: Annals of the Rheumatic Diseases