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Mensenchymal stem cell transplantation

Zenan Huang, Liang Zhang, Xinmin Feng, Tao Chen, Songchao Bi
Degenerative disc disease is a worldwide problem, however, conservative treatment and surgical treatment can only partly relieve symptoms, but do not have therapeutic effect on the degenerated intervertebral disc (IVD) itself. The use of stem cell transplantation has become one of the most popular treatments. With gradually understanding of the endogenous mechanism of stem cells migration and movement in vivo, endogenous IVD stem cells can be activated to repair and reconstruct the degenerated IVD. Nucleus pulposus mensenchymal stem cells exhibit more potent biological activity in the hypoxic environment of the IVD...
April 2017: Medical Hypotheses
T Qin, C J Liu, H W Zhang, Y F Pan, Q Tang, J K Liu, Y Z Wang, M X Hu, F Xue
This study aimed to investigate the effect of inhibitors of the NF-kΒ alpha mutant gene (IkBaM) delivery to mensenchymal stem cells (MSCs) on rat chronic pancreatitis (CP). A total of 120 Sprague-Dawley rats were randomly divided into 6 groups of 20: Group A was injected with sterile saline solution, Group B was injected with allogenic MSCs, Group C1 was injected with allogenic IkBαM-MSCs cultured in vitro 4 h before CP modeling, Group C2 was injected with allogenic IkBαM-MSCs cultured in vitro during CP modeling, Group C3 was cultured with allogenic IkBαM-MSCs cultured in vitro 4 h after CP modeling, and Group D was injected with rAAV2-MSCs...
January 21, 2014: Genetics and Molecular Research: GMR
Hao Yan, Tong Chen
Bone marrow mensenchymal stem cells (BM-MSCs) are capable of supporting the survival, differentiation and migration of hematopoietic stem cell, and have a profound application prospect in transplantation and treatment of graft-versus-host disease (GVHD). This review aims to illustrate the interaction between BM-MSCs and other intra-bone marrow cells, including hematopoietic stem cells, endothelial cells and osteoblasts. The investigation of their regulating mechanism will help better understanding of the BM-MSCs' role in hematopoiesis...
August 2013: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Lei Zhang, Xuefeng Tan, Chuanming Dong, Linqing Zou, Heyan Zhao, Xinhua Zhang, Meiling Tian, Guohua Jin
We isolated and expanded fibroblast-like cells from the Wharton's jelly of human umbilical cord successfully. Immunocytochemistry showed that they were positive for several markers of mesenchymal stem cells (CD73, CD90, and CD105) and integrin markers (CD29 and CD44), but negative for a hematopoietic cell maker (CD45) and an endothelial cell marker (CD31). Their differentiation into osteocytes and adipocytes under specific conditions indicated that they had multi-lineage differentiation potential. Therefore these results proved that the cells we obtained from Wharton's jelly were human umbilical cord mensenchymal stem cells (hUCMSCs)...
October 2012: International Journal of Developmental Neuroscience
Huan-Tian Zhang, Zhen-Gang Zha, Jia-Hui Cao, Zu-Jian Liang, Hao Wu, Ming-Tao He, Xiao Zang, Ping Yao, Jia-Qing Zhang
BACKGROUND: Transplantation of mensenchymal stem cells (MSCs) has been proposed as a promising way for tissue engineering. However, the application of MSCs for transplantation will undergo apoptosis due to the extremely harsh microenvironment such as excessive inflammation. Apigenin (API) has been reported to protect cells against inflammatory damage and cell death by exhibiting anti-inflammatory and anti-oxidative capacity. Here we investigated the modulatory effects of API in lipopolysaccharide (LPS)-mediated inflammation and apoptosis of MSCs, and further defined the underlying mechanism...
November 2011: Chinese Medical Journal
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