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Mesenchymal cell transplantation lung fibrosis

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https://www.readbyqxmd.com/read/27895584/induced-pluripotent-stem-cells-inhibit-bleomycin-induced-pulmonary-fibrosis-in-mice-through-suppressing-tgf-%C3%AE-1-smad-mediated-epithelial-to-mesenchymal-transition
#1
Yan Zhou, Zhong He, Yuan Gao, Rui Zheng, Xiaoye Zhang, Li Zhao, Mingqi Tan
Pulmonary fibrosis is a progressive and irreversible fibrotic lung disorder with high mortality and few treatment options. Recently, induced pluripotent stem (iPS) cells have been considered as an ideal resource for stem cell-based therapy. Although, an earlier study demonstrated the therapeutic effect of iPS cells on pulmonary fibrosis, the exact mechanisms remain obscure. The present study investigated the effects of iPS cells on inflammatory responses, transforming growth factor (TGF)-β1 signaling pathway, and epithelial to mesenchymal transition (EMT) during bleomycin (BLM)-induced lung fibrosis...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27798371/oncostatin-m-preconditioned-mesenchymal-stem-cells-alleviate-bleomycin-induced-pulmonary-fibrosis-through-paracrine-effects-of-the-hepatocyte-growth-factor
#2
Ying-Wei Lan, Si-Min Theng, Tsung-Teng Huang, Kong-Bung Choo, Chuan-Mu Chen, Han-Pin Kuo, Kowit-Yu Chong
: : Mesenchymal stem cells (MSCs) are widely considered for treatment of pulmonary fibrosis based on the anti-inflammatory, antifibrotic, antiapoptotic, and regenerative properties of the cells. Recently, elevated levels of oncostatin M (OSM) have been reported in the bronchoalveolar lavage fluid of a pulmonary fibrosis animal model and in patients. In this work, we aimed to prolong engrafted MSC survival and to enhance the effectiveness of pulmonary fibrosis transplantation therapy by using OSM-preconditioned MSCs...
October 18, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27754275/sy-18-1-translational-research-in-pah
#3
Wook-Jin Chung
Pulmonary arterial hypertension (PAH) is a life-threatening disorder with a poor prognosis and causes pulmonary vascular remodeling accompanied with increased pulmonary arterial medial wall thickness and fibrosis, which leads to vascular and right ventricular (RV) dysfunction. Despite treatment with prostacyclin, endothelin antagonist, and phosphodiesterase-5 inhibitors the 1-year mortality rate of PAH still remains high. Recent registries, clinical trials, and basic researches have been increasing the knowledge of PAH and it would contribute to potential therapeutic strategies and better clinical outcome...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27688156/mesenchymal-stem-cells-in-the-treatment-of-chronic-lung-disease
#4
Sophie Wecht, Mauricio Rojas
Mesenchymal stem cells (MSCs) are a populace of non-haematopoietic multipotent stromal cells, which have the ability to differentiate into tissue derived from a single germ layer. MSCs have been isolated from various sites, including adipose tissue, skeletal muscle, synovium, spleen, thymus, lung and amniotic fluid, but are most often isolated from bone marrow. MSCs have several valuable functions that make them a promising therapeutic option in the field of regenerative medicine, including the secretion of anti-inflammatory cytokines and growth factors, the migration of cells to the site of injury when administered and the ability to 'rescue' cells through the transfer of functional mitochondria...
November 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27667460/-human-placental-mesenchymal-stem-cells-of-fetal-origin-relieves-mouse-pulmonary-fibrosis-via-downregulating-myd88-and-tgf-%C3%AE-signaling-pathway
#5
Jin Tao, Qinglun Li, Xiaowei Ma, Fei Han, Xiaoming Liu, Jun Wei, Yongzhao Zhu
Objective To investigate the therapeutic effect and mechanism of human placental mesenchymal stem cells of fetal origin (hfPMSCs) cultured in serum-free medium on mouse pulmonary fibrosis induced by bleomycin treatment. Methods Human hfPMSCs were cultured and identified by flow cytometry. Fifteen 6-week-old male SPF C57BL/6J mice were divided into 3 groups: bleomycin treatment group, hfPMSCs transplantation group and negative control group. Pulmonary fibrosis model was induced in the mice of bleomycin treatment group and hfPMSCs transplantation group with bleomycin (1 μg/L, 50 μL) via intratracheal instillation...
October 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27498952/little-evidence-for-epithelial-mesenchymal-transition-in-a-murine-model-of-airway-fibrosis-induced-by-repeated-naphthalene-exposure
#6
Osamu Watanabe, Takao Tsuji, Ryota Kikuchi, Masayuki Itoh, Hiroyuki Nakamura, Kazutetsu Aoshiba
Recent evidence suggests that epithelial-mesenchymal transition (EMT) is involved in the pathogenesis of airway obstructive diseases, such as chronic obstructive pulmonary disease, asthma and bronchiolitis obliterans syndrome after lung transplantation. However, whether EMT occurs in an experimental model of airway fibrosis is not well known. We explored evidence of EMT in a murine model of airway fibrosis induced by repeated exposure to naphthalene. Mice were administered intraperitoneal injections of naphthalene or corn oil vehicle once weekly for 14 consecutive weeks...
October 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27026415/everolimus-induced-epithelial-to-mesenchymal-transition-emt-in-bronchial-pulmonary-cells-when-the-dosage-does-matter-in-transplantation
#7
Paola Tomei, Valentina Masola, Simona Granata, Gloria Bellin, Pierluigi Carratù, Miriam Ficial, Valentina Anna Ventura, Maurizio Onisto, Onofrio Resta, Giovanni Gambaro, Marco Chilosi, Antonio Lupo, Gianluigi Zaza
BACKGROUND: Everolimus (EVE) is a mammalian target of rapamycin inhibitor (mTOR-I) widely used in transplantation that may determine some severe adverse events, including pulmonary fibrosis. The pathogenic mechanism of mTOR-I-associated pulmonary toxicity is still unclear, but epithelial to mesenchymal transition (EMT) of bronchial/pulmonary cells may play a role. METHODS: Three cell lines-human type II pneumocyte-derived A549, normal bronchial epithelial, and bronchial epithelial homozygous for the delta F508 cystic fibrosis-causing mutation-were treated with EVE or tacrolimus at different concentrations...
March 29, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/26995852/effect-of-intratracheal-administration-of-adipose-derived-stromal-cells-on-bleomycin-induced-lung-injury-in-a-rat-model
#8
Masato Uji, Akira Nakada, Tatsuo Nakamura, Kazuto Hirata
BACKGROUND: Mesenchymal stromal cells (MSCs) have been intensively investigated in regenerative medicine. Among the different types of MSCs, adipose tissue-derived stromal cells (ASCs) can be obtained with relatively less invasive techniques. Since ASC administration is a candidate strategy for the treatment of refractory diseases including pulmonary fibrosis, we investigated whether intratracheal injection of ASCs had therapeutic potential against bleomycin (BLM)-induced lung injury in rats...
December 2015: Osaka City Medical Journal
https://www.readbyqxmd.com/read/26884454/the-matricellular-protein-ccn1-enhances-tgf-%C3%AE-1-smad3-dependent-profibrotic-signaling-in-fibroblasts-and-contributes-to-fibrogenic-responses-to-lung-injury
#9
Ashish R Kurundkar, Deepali Kurundkar, Sunad Rangarajan, Morgan L Locy, Yong Zhou, Rui-Ming Liu, Jaroslaw Zmijewski, Victor J Thannickal
Matricellular proteins mediate pleiotropic effects during tissue injury and repair. CCN1 is a matricellular protein that has been implicated in angiogenesis, inflammation, and wound repair. In this study, we identified CCN1 as a gene that is differentially up-regulated in alveolar mesenchymal cells of human subjects with rapidly progressive idiopathic pulmonary fibrosis (IPF). Elevated levels of CCN1 mRNA were confirmed in lung tissues of IPF subjects undergoing lung transplantation, and CCN1 protein was predominantly localized to fibroblastic foci...
June 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/26665938/mesenchymal-stem-cells-and-lung-transplantation-a-couple-for-a-perfect-relationship
#10
Mohamed S A Mohamed
With the increased incidence of lung and other organ failure, organ transplantation becomes a frequent surgical intervention. Research is focused on improving the practice of lung and other organ transplantation in order to improve the clinical outcome and to decrease the incidence of post-operative complications. This manuscript represents the author's view of the possibility of improving the lung transplantation outcome through the co-transplantation of mesenchymal stem cells, and the expected positive effects of that application...
2015: Journal of Stem Cells
https://www.readbyqxmd.com/read/26432923/therapeutic-benefits-of-young-but-not-old-adipose-derived-mesenchymal-stem-cells-in-a-chronic-mouse-model-of-bleomycin-induced-pulmonary-fibrosis
#11
Jun Tashiro, Sharon J Elliot, David J Gerth, Xiaomei Xia, Simone Pereira-Simon, Rhea Choi, Paola Catanuto, Shahriar Shahzeidi, Rebecca L Toonkel, Rahil H Shah, Fadi El Salem, Marilyn K Glassberg
The observation that pulmonary inflammatory lesions and bleomycin (BLM)-induced pulmonary fibrosis spontaneously resolve in young mice, whereas remaining irreversible in aged mice suggests that impairment of pulmonary regeneration and repair is associated with aging. Because mesenchymal stem cells (MSCs) may promote repair after injury, we postulated that differences in MSCs from aged mice may underlie postinjury fibrosis in aging. The potential for young-donor MSCs to inhibit BLM-induced pulmonary fibrosis in aged male mice (>22 months) has not been studied...
December 2015: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/26376362/bone-marrow-transplantation-alters-lung-antigen-presenting-cells-to-promote-th17-response-and-the-development-of-pneumonitis-and-fibrosis-following-gammaherpesvirus-infection
#12
X Zhou, H Loomis-King, S J Gurczynski, C A Wilke, K E Konopka, C Ptaschinski, S M Coomes, Y Iwakura, L F van Dyk, N W Lukacs, B B Moore
Hematopoietic stem cell transplantation (HSCT) efficacy is limited by numerous pulmonary complications. We developed a model of syngeneic bone marrow transplantion (BMT) followed by infection with murine gamma herpesvirus-68 that results in pneumonitis and fibrosis and mimics human "noninfectious" HSCT complications. BMT mice experience increased early lytic replication, but establish viral latency by 21 days post infection. CD4 T cells in BMT mice are skewed toward interleukin (IL)-17A rather than interferon (IFN)-γ production...
May 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/26359426/adult-lung-spheroid-cells-contain-progenitor-cells-and-mediate-regeneration-in-rodents-with-bleomycin-induced-pulmonary-fibrosis
#13
Eric Henry, Jhon Cores, M Taylor Hensley, Shirena Anthony, Adam Vandergriff, James B M de Andrade, Tyler Allen, Thomas G Caranasos, Leonard J Lobo, Ke Cheng
UNLABELLED: Lung diseases are devastating conditions and ranked as one of the top five causes of mortality worldwide according to the World Health Organization. Stem cell therapy is a promising strategy for lung regeneration. Previous animal and clinical studies have focused on the use of mesenchymal stem cells (from other parts of the body) for lung regenerative therapies. We report a rapid and robust method to generate therapeutic resident lung progenitors from adult lung tissues. Outgrowth cells from healthy lung tissue explants are self-aggregated into three-dimensional lung spheroids in a suspension culture...
November 2015: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/26339340/bone-marrow-mesenchymal-stem-cells-protect-against-bleomycin-induced-pulmonary-fibrosis-in-rat-by-activating-nrf2-signaling
#14
Shirong Ni, Dexuan Wang, Xiaoxiao Qiu, Lingxia Pang, Zhangjuan Song, Kunyuan Guo
UNLABELLED: Pulmonary fibrosis is a progressive and lethal disorder. Although the precise mechanisms of pulmonary fibrosis are not fully understood, oxidant/antioxidant may play an important role in many of the processes of inflammation and fibrosis. Keap1-Nrf2-ARE pathway represents one of the most important cellular defense mechanisms against oxidative stress. Mesenchymal stem cells (MSC) are in clinical trials for widespread indications including musculoskeletal, neurological, cardiac and haematological disorders...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26305093/optimal-route-for-human-umbilical-cord-blood-derived-mesenchymal-stem-cell-transplantation-to-protect-against-neonatal-hyperoxic-lung-injury-gene-expression-profiles-and-histopathology
#15
Dong Kyung Sung, Yun Sil Chang, So Yoon Ahn, Se In Sung, Hye Soo Yoo, Soo Jin Choi, Soo Yoon Kim, Won Soon Park
The aim of this study was to determine the optimal route of mesenchymal stem cell (MSC) transplantation. To this end, gene expression profiling was performed to compare the effects of intratracheal (i.t.) versus intravenous (i.v.) MSC administration. Furthermore, the therapeutic efficacy of each route to protect against neonatal hyperoxic lung injury was also determined. Newborn Sprague-Dawley rats were exposed to hyperoxia (90% oxygen) from birth for 14 days. Human umbilical cord blood-derived MSCs labeling with PKH26 were transplanted through either the i...
2015: PloS One
https://www.readbyqxmd.com/read/26254424/coming-to-terms-with-tissue-engineering-and-regenerative-medicine-in-the-lung
#16
REVIEW
Y S Prakash, Daniel J Tschumperlin, Kurt R Stenmark
Lung diseases such as emphysema, interstitial fibrosis, and pulmonary vascular diseases cause significant morbidity and mortality, but despite substantial mechanistic understanding, clinical management options for them are limited, with lung transplantation being implemented at end stages. However, limited donor lung availability, graft rejection, and long-term problems after transplantation are major hurdles to lung transplantation being a panacea. Bioengineering the lung is an exciting and emerging solution that has the ultimate aim of generating lung tissues and organs for transplantation...
October 1, 2015: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/26178702/inhibition-of-bleomycin-induced-pulmonary-fibrosis-by-bone-marrow-derived-mesenchymal-stem-cells-might-be-mediated-by-decreasing-mmp9-timp-1-inf-%C3%AE-and-tgf-%C3%AE
#17
Shi-huan Yu, Li-jie Liu, Bin Lv, Chun-li Che, Da-ping Fan, Li-feng Wang, Yi-mei Zhang
The study was aimed to investigate the mechanism and administration timing of bone marrow-derived mesenchymal stem cells (BMSCs) in bleomycin (BLM)-induced pulmonary fibrosis mice. Thirty-six mice were divided into six groups: control group (saline), model group (intratracheal administration of BLM), day 1, day 3 and day 6 BMSCs treatment groups and hormone group (hydrocortisone after BLM treatment). BMSCs treatment groups received BMSCs at day 1, 3 or 6 following BLM treatment, respectively. Haematoxylin and eosin and Masson staining were conducted to measure lung injury and fibrosis, respectively...
August 2015: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/26169784/hypoxic-preconditioning-enhances-mesenchymal-stromal-cell-lung-repair-capacity
#18
COMMENT
Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco
Idiopathic pulmonary fibrosis is a progressive, irreversible, debilitating, and fatal lung disease, characterized by parenchymal fibrosis with reduced lung volumes and respiratory failure. No lasting option for therapy is available other than transplantation. Mesenchymal stem/stromal cells home to sites of injury, decrease inflammation, have antifibrotic properties, and promote epithelial tissue repair, so their use has been suggested as potential therapy for idiopathic pulmonary fibrosis. Despite reported benefits, the amount of mesenchymal stromal cells engrafting to the lung decreases substantially soon after administration...
2015: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26153152/mr-tracking-of-spio-labeled-mesenchymal-stem-cells-in-rats-with-liver-fibrosis-could-not-monitor-the-cells-accurately
#19
Bin Zhou, Dan Li, Jiesheng Qian, Zhengran Li, Pengfei Pang, Hong Shan
Our previous study showed that in vivo magnetic resonance (MR) imaging is effective in tracking superparamagnetic iron oxide (SPIO)-labeled bone marrow mesenchymal stem cells (BMSCs) in rats with liver fibrosis. SPIO-labeling-induced signal reduction on MR images was completely reversed within 15 days after transplantation. It is still unclear whether the signal changes in MR imaging could reflect the number of transplanted cells in the liver. In the present study, BMSCs of male rats were doubly labeled with enhanced green fluorescent protein (EGFP) and SPIO and injected intravascularly into female rats with liver fibrosis...
November 2015: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/26116593/cyclophosphamide-combined-with-bone-marrow-mesenchymal-stromal-cells-protects-against-bleomycin-induced-lung-fibrosis-in-mice
#20
Jiabo Xu, Li Li, Jianfei Xiong, Ying Zheng, Qing Ye, Yanqin Li
INTRODUCTION: To examine the effects and possible mechanism of the immunosuppressant agent cyclophosphamide (CP) combined with bone marrow mesenchymal stromal cells (BM-MSCs) on bleomycin induced lung fibrosis in mice. METHODS: BM-MSCs labeled with red fluorescence protein (RFP) from male Friend virus B-type(FVB) mice were cultured in vitro. Pulmonary fibrosis(PF) was induced in female wild type FVB mice and mice were randomly divided into five groups: control, model, CP, BM-MSCs, and BM-MSCs+CP...
2015: Annals of Clinical and Laboratory Science
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