keyword
MENU ▼
Read by QxMD icon Read
search

I-131

keyword
https://www.readbyqxmd.com/read/28710805/a-method-to-measure-the-absorbed-dose-of-the-thyroid-during-i-131-therapy-using-a-collar-detector-system-and-a-spect-acquisition
#1
Koen van Gils, Peter Brinks, Jules Lavalaye, Hein J Verberne, Jan B A Habraken
PURPOSE: Due to variations in biological half-life, accurate thyroid dosimetry for I-131 therapy is not trivial in clinical practice. In recent publications, systems are described to measure the uptake of I-131 in the thyroid repeatedly over time. In this work we present a method to calculate patient specific pharmacokinetics and absorbed dose using such a collar detector system (CoTI) in combination with a SPECT acquisition and a two-compartment model fit. METHODS: For three patients receiving I-131 therapy for benign thyroid conditions, the complete uptake profile is measured over a period of 15 to 25 days after administration...
July 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28697989/sialoendoscopy-combined-with-an-internal-stent-and-postoperative-massage-as-a-comprehensive-treatment-of-delayed-i-131-induced-parotitis
#2
Q Meng, W Fang, X Long, M Deng, J Li, J Ke
A common complication of radioiodine (I(131)) treatment of thyroid cancer is parotitis. Here we describe our clinical experience in treating delayed I(131)-induced parotitis using sialoendoscopy together with an internal stent and postoperative massage. In this retrospective cohort study we reviewed 32 patients who were treated in that way under general anaesthesia between July 2010 and March 2015. Their age, sex, and the time to development of the parotitis were collected from the hospital's database. All patients were evaluated using a visual analogue scale (VAS), sialography, and computed tomography preoperatively...
July 8, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28696016/central-nervous-system-relapse-of-rhabdomyosarcoma
#3
Brian De, Michael D Kinnaman, Leonard H Wexler, Kim Kramer, Suzanne L Wolden
PURPOSE: The optimal management of central nervous system (CNS) relapse of rhabdomyosarcoma (RMS) is unclear. We examined diagnosis, management, and outcomes of patients with RMS developing CNS relapse. METHODS: Records of 23 patients diagnosed with CNS relapse between 1999 and 2016 were reviewed. Median age at presentation of CNS relapse was 15 years (range, 1-34 years). High-risk features at initial presentation were as follows: 16 alveolar patients, 13 Stage IV, and 13 with primary tumor in parameningeal locations...
July 11, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28688088/early-stimulated-thyroglobulin-for-response-prediction-after-recombinant-human-thyrotropin-aided-radioiodine-therapy
#4
Hee Jeong Park, Jung-Joon Min, Hee-Seung Bom, Jahae Kim, Ho-Chun Song, Seong Young Kwon
OBJECTIVE: Measurement of recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin (Tg) is generally recommended 72 h after the second rhTSH injection. However, due to the acute effect of I-131 on thyrocytes, Tg measured after radioiodine therapy (RIT) would not accurately reflect the thyroid tissue burden. We aimed to determine predictive values of serum Tg level measured just before rhTSH-aided RIT and to compare the results obtained just after RIT in patients with differentiated thyroid carcinoma (DTC)...
July 7, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28680197/association-between-volumetric-analysis-of-lung-metastases-on-f-18-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-and-short-term-progression-after-i-131-therapy-for-differentiated-thyroid-carcinoma
#5
Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Hiroshi Honda
PURPOSE: Lung metastases (LMs) and their radioiodine uptake affect prognosis in patients with differentiated thyroid carcinoma (DTC). We herein investigate the value of metabolic tumor volume (MTV) in LMs on positron emission tomography/computed tomography (PET/CT) using 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18 FDG PET/CT) in predicting short-term progression after initial I-131 therapy in DTC patients. MATERIALS AND METHODS: We retrospectively evaluated 111 DTC patients with LMs...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28677070/i-131-biokinetics-of-remnant-normal-thyroid-tissue-and-residual-thyroid-cancer-in-patients-with-differentiated-thyroid-cancer-comparison-between-recombinant-human-tsh-administration-and-thyroid-hormone-withdrawal
#6
Chae Moon Hong, Choon-Young Kim, Seung Hyun Son, Ji-Hoon Jung, Chang-Hee Lee, Ju Hye Jeong, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
OBJECTIVE: The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also evaluated. METHODS: A total of 57 patients who received I-131 therapy (2.96-7.4 GBq) were retrospectively included. TSH stimulation was achieved by recombinant human thyrotropin (rhTSH) or by thyroid hormone withdrawal (THW)...
July 4, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28662277/thyroid-neoplasia-risk-is-increased-nearly-30-years-after-the-chernobyl-accident
#7
Mykola Tronko, Alina V Brenner, Tetiana Bogdanova, Victor Shpak, Valeriy Oliynyk, Elizabeth K Cahoon, Vladimir Drozdovitch, Mark P Little, Valeriy Tereshchenko, Galyna Zamotayeva, Galyna Terekhova, Lyudmila Zurnadzhi, Maureen Hatch, Kiyohiko Mabuchi
To evaluate risk of thyroid neoplasia nearly 30 years following exposure to radioactive iodine (I-131) from the 1986 Chernobyl nuclear accident, we conducted a fifth cycle of thyroid screening of the Ukrainian-American (UkrAm) cohort during 2012-2015, following four previous screening cycles started in 1998. We identified 47 thyroid cancers (TC) and 33 follicular adenomas (FA) among 10,073 individuals who were <18 years at the time of the accident and had a mean I-131 dose of 0.62 Gy. We found a significant I-131 dose response for both TC and FA, with an excess odd ratio per Gy of 1...
June 29, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28620714/the-outcome-of-i-131-ablation-therapy-for-intermediate-and-high-risk-differentiated-thyroid-cancer-using-a-strict-definition-of-successful-ablation
#8
Ken Watanabe, Mayuki Uchiyama, Kunihiko Fukuda
PURPOSE: This article examines the outcome of radioactive iodine ablation therapy for thyroid cancer in high-risk patients and investigates background factors influencing ablation failure. MATERIALS AND METHODS: We included 91 patients in this retrospective analysis and evaluated the ablation success rate. Successful ablation was defined as the absence of visible iodine-131 (I-131) accumulation in the thyroid bed after whole-body scans and thyroglobulin levels <2 ng/ml in a TSH-stimulated state after ablation...
June 15, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28553183/an-evaluation-of-deviation-from-the-international-atomic-energy-agency-international-commission-on-radiological-protection-proposed-equation-for-calculation-of-radiation-dose-rate-emanating-from-the-patients-with-differentiated-thyroid-cancer-undergoing-radioiodine
#9
Forough Jafarian Dehkordi, Behrouz Rasuli, Ali Mahmoud-Pashazadeh
The main purpose of this study was to investigate dose rate emanating from patients treated with (131)I to evaluate which of the theoretical formulas, inverse-square law (ISL) and International Atomic Energy Agency-International Commission on Radiological Protection (IAEA-ICRP) suggested equation, can provide a sufficiently close approximation of the measured dose rate. Measurements were performed based on the IAEA safety report No. 63 method at 0, 12, 24, and 48 h after administration of radioiodine at a distance of 1 m for 69 patients and for the rest of 67 patients, dose rate was measured at 2, 4, 24, and 48 h at a distance of 2 m...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28510122/anti-thyroglobulin-antibodies-do-not-significantly-increase-the-risk-of-finding-iodine-avid-metastases-on-post-radioactive-iodine-ablation-scan-in-low-risk-thyroid-cancer-patients
#10
F Nabhan, K Porter, L Senter, M D Ringel
OBJECTIVE: Post-operative thyroglobulin (Tg) levels can predict the likelihood of residual cancer, including distant metastases, thereby influencing postsurgical treatment strategies even in patients with low-risk disease. Circulating anti-thyroglobulin antibodies (anti-Tg Abs) interfere with Tg measurement preventing this clinical use. It is not known if the presence of anti-Tg Abs predicts metastatic disease on post-therapy scan in patients with low-risk disease or if they should influence the use or dose of I-131 therapy...
May 16, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28450931/cell-penetrating-peptide-of-sodium-iodide-symporter-effect-on-the-i-131-radiotherapy-on-thyroid-cancer
#11
Yi-Xiang Fan, Zhi-Xin Liang, Qing-Zhu Liu, Han Xiao, Ke-Bin Li, Ji-Zhen Wu
The aim of the present study was to clarify whether the cell penetrating peptide of sodium-iodide symporter (NIS) has an effect on the I-131 radiotherapy of thyroid cancer. Firstly, we combined the HIV-1 TAT peptide (a cell penetrating peptide, dTAT) and established a nanoparticle vector (dTAT NP) to study the delivery efficiency of this cell-penetrating strategy for tumor-targeted gene delivery. dTAT NP was transfected into cultured TPC-1 cells as a model to study the effects of I-131 radiotherapy on thyroid cancer...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28450565/reply-fixed-100-mci-i-131-activity-for-metastatic-thyroid-cancer-therapy-ignores-science-and-history
#12
Desiree Deandreis, Martin Schlumberger, R Michael Tuttle
No abstract text is available yet for this article.
April 27, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28397060/monte-carlo-simulation-of-the-rbe-of-i-131-radiation-using-dna-damage-as-biomarker
#13
Ahad Ollah Ezzati, Ali Mahmoud-Pashazadeh, Matthew T Studenski
In general, a weighting factor of one is applied for low linear energy transfer radiations. However, several studies indicate that relative biological effectiveness (RBE) of low energy photons and electrons is greater than one. The aim of this current study was calculating the RBE of I-131 radiation relative to Co-60 gamma photons in 100 μm spheroid cells using Monte Carlo (MC) simulations. These calculations were compared to experimentally measured results. MCNPX2.6 was used to simulate the I-131 and Co-60 irradiation setups and calculate the secondary electron spectra at energies higher than 1 keV with varying oxygen concentrations...
April 10, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28385792/fixed-100-mci-i-131-activity-for-metastatic-thyroid-cancer-therapy-ignores-science-and-history
#14
Walter Jentzen, Alan E Nahum, Andreas Bockisch, Ina Binse, Mark Tulchinsky
No abstract text is available yet for this article.
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28368520/risk-of-thyroid-nodules-in-residents-of-belarus-exposed-to-chernobyl-fallout-as-children-and-adolescents
#15
Elizabeth K Cahoon, Eldar A Nadirov, Olga N Polanskaya, Vasilina V Yauseyenka, Ilya V Velalkin, Tamara I Yeudachkova, Tamara I Maskvicheva, Victor F Minenko, Wayne Liu, Vladimir Drozdovitch, Kiyohoko Mabuchi, Mark P Little, Lydia B Zablotska, Robert J McConnell, Maureen Hatch, Kamau O Peters, Alexander V Rozhko, Alina V Brenner
Context: Although radiation exposure is an important predictor of thyroid cancer upon diagnosis of a thyroid nodule, the relationship between childhood radiation exposure and thyroid nodules has not been comprehensively evaluated. Objective: To examine the association between internal I-131 thyroid radiation dose and thyroid nodules in young adults exposed during childhood. Design, setting, and participants: In this cross-sectional study, we screened 11,970 residents of Belarus aged ≤18 years at the time of the Chernobyl nuclear accident (April 1986) for thyroid disease (median age 21 years) with thyroid palpation, ultrasonography, blood and urine analysis, and medical follow-up when appropriate...
March 22, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28340756/simultaneous-quantification-of-iodine-and-high-valent-metals-via-icp-ms-under-acidic-conditions-in-complex-matrices
#16
Kristina Brix, Christina Hein, Jonas Michael Sander, Ralf Kautenburger
The determination of iodine as a main fission product (especially the isotopes I-129 and I-131) of stored HLW in a disposal beside its distribution as a natural ingredient of many different products like milk, food and seawater is a matter of particular interest. The simultaneous ICP-MS determination of iodine as iodide together with other elements (especially higher valent metal ions) relevant for HLW is analytically very problematic. A reliable ICP-MS quantification of iodide must be performed at neutral or alkaline conditions in contrast to the analysis of metal ions which are determined in acidic pH ranges...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28326838/ctla-4-gene-polymorphisms-associate-with-efficacy-of-postoperative-radioiodine-131-for-differentiated-thyroid-carcinoma
#17
De-Feng Chang, Xiao-Hong Chen, Jing Huang, Ya-Mei Sun, Da-Yong Zhu, Zhong-Qing Xu
AIM: To investigate the association of CTLA-4 polymorphisms with efficacy of postoperative radioiodine-131 (I-131) treatment for differentiated thyroid carcinoma (DTC). METHODS: A total of 324 DTC patients and 350 healthy individuals were enrolled in our study. Patients received I-131 remnant ablation following surgical resection. Based on the treatment efficacy, patients were divided into the effective (n = 183) and ineffective groups (n = 141). CTLA-4 polymorphisms (+49A>G, CT60A>G and -318C>T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism...
March 3, 2017: Future Oncology
https://www.readbyqxmd.com/read/28291381/selimetry-a-multicentre-i-131-dosimetry-trial-a-clinical-perspective
#18
MULTICENTER STUDY
Jonathan Wadsley, Rebecca Gregory, Glenn Flux, Kate Newbold, Yong Du, Laura Moss, Andrew Hall, Louise Flanagan, Sarah R Brown
Treatment options for patients with thyroid cancer that is no longer sensitive to iodine therapy are limited. Those treatments which currently exist are associated with significant toxicity. The SELIMETRY trial (EudraCT No 2015-002269-47) aims to investigate the role of the MEK inhibitor Selumetinib in resensitizing advanced iodine refractory differentiated thyroid cancer to radioiodine therapy. Patients deemed to have sufficient iodine uptake in previously iodine refractory lesions after 4 weeks of Selumetinib therapy will be given an empirical activity of 5...
May 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28255354/radionuclide-i-131-labeled-albumin-paclitaxel-nanoparticles-for-synergistic-combined-chemo-radioisotope-therapy-of-cancer
#19
Longlong Tian, Qian Chen, Xuan Yi, Guanglin Wang, Jie Chen, Ping Ning, Kai Yang, Zhuang Liu
Development of biocompatible/biodegradable materials with multiple functionalities via simple methods for cancer combination therapy has attracted great attention in recent years. Herein, paclitaxel (PTX), a popular anti-tumor chemotherapeutic drug, is used to induce the self-assembly of human serum albumin (HSA) pre-labeled with radionuclide I-131, obtaining (131)I-HSA-PTX nanoparticles for combined chemotherapy and radioisotope therapy (RIT) of cancer. Such (131)I-HSA-PTX nanoparticles show prolonged blood circulation time, high tumor specific uptake and excellent intra-tumor penetration ability...
2017: Theranostics
https://www.readbyqxmd.com/read/28250909/retrospective-biological-dosimetry-at-low-and-high-doses-of-radiation-and-radioiodine-impact-on-individual-susceptibility-to-ionizing-radiation
#20
Antonina Cebulska-Wasilewska, Mateusz Krzysiek, Grażyna Krajewska, Artur Stępień, Paweł Krajewski
Iodine-131 (I-131) is often used in thyroid diagnostics and therapy. External and internal exposure to radioiodine can lead to molecular and cellular damage in peripheral blood lymphocytes. The aim of this study was to explore the influence of low and high doses of I-131 on susceptibility to ionizing radiation. Study groups consisted of 30 individuals free of thyroid diseases, 41 patients exposed diagnostically to low doses of I-131, and 37 hyperthyroidism patients exposed therapeutically to high doses. The standardized DNA repair competence assay was used to test the efficacy of the fast DNA repair process in G0 cells...
2017: Genome Integrity
keyword
keyword
12019
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"