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Raja N Mahesh, Pranay R Korpole, Ganesh Shetty, Handrashekar U Kudru, Shivashankara K Nagiri
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Frederik A Verburg, Markus Luster, Luca Giovanella
No abstract text is available yet for this article.
October 10, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Rame Miftari, Valdete Topçiu, Adem Nura, Valdete Haxhibeqiri
PURPOSE: Papillary carcinoma is the most frequent type of thyroid cancer and was considered the most benign of all thyroid carcinomas, with a low risk of distant metastases. However, there are some variants of papillary thyroid carcinoma that have affinity to spread in many organs, such as: lymph nodes, lungs and bones. AIM: The aim of this study was presentation of a case with papillary carcinoma of the thyroid gland, very persistent and resistant in treatment with I 131...
July 27, 2016: Medical Archives
Mehran Pashnehsaz, Abbas Takavar, Sina Izadyar, Seyed Salman Zakariaee, Mahmoud Mahmoudi, Reza Paydar, Parham Geramifar
Iodine-131 (I-131) therapy is one of the conventional approaches in the treatment of patients with differentiated thyroid carcinoma (DTC). The radioiodine agents also accumulate in the other organs that cause pain and damage to the patients. Radioiodine therapy is associated with various gastrointestinal (GI) toxicities. In this study, GI side effects of the radioiodine therapy were investigated. GI toxicities of the radioiodine therapy were studied in 137 patients with histologically proven DTC in Jun-Nov 2014...
September 2016: World Journal of Nuclear Medicine
Veda Padma Priya Selvakumar, Ashish Goel, Kapil Kumar
Cervical cord compression secondary to extension of a long standing papillary thyroid carcinoma as well as multiple cases of distal cord compression from occult follicular thyroid carcinoma have been reported. But cervical cord compression from Papillary Thyroid Carcinoma has not been reported so far. Forty eight year old lady presented with progressive quadriparesis of 2 months duration. MRI of the cervical spine showed destructive lesion with soft tissue component in vertebral bodies and posterior elements of C4-C6 vertebrae with cord compression along with a large thyroid mass extending to retrosternal region likely malignant...
September 2016: Indian Journal of Surgical Oncology
Vinuta Mohan, Robert Lind
Graves' disease is the most common cause of hyperthyroidism. If left untreated, patients may have multiple systemic complications such as cardiac, reproductive, and skeletal disease. Thionamides, such as methimazole and propylthiouracil, and I(131) iodine ablation are the most commonly prescribed treatment for Graves' disease. Total thyroidectomy is often overlooked for treatment and is usually only offered if the other options have failed. In our case, we discuss a patient who was admitted to our medical center with symptomatic hyperthyroidism secondary to long-standing Graves' disease...
2016: Journal of Community Hospital Internal Medicine Perspectives
Nanno Schreuder, Ilahä Mamedova, Frank G A Jansman
PURPOSE: The acute porphyrias are a group of rare metabolic disorders of the heme biosynthetic pathway. Carriers of the acute porphyria gene are prone to potentially fatal acute attacks, which can be precipitated by drug exposure. It is therefore important to know whether a drug is safe for carriers of the acute porphyria gene. In this study, radiopharmaceuticals were assessed on their porphyrogenicity (ie, the potential of a drug to induce an attack). METHODS: The assessment was conducted by classifying the drugs according to the Thunell model...
August 24, 2016: Clinical Therapeutics
M Zehtabian, N Dehghan, M Danaei Ghazanfarkhani, M Haghighatafshar, S Sina
The family members or friends of the patients undergoing treatment using radioiodine in nuclear medicine are inevitably exposed to ionization radiation. The purpose of this study is measurement of the dose received by the people taking care of the thyroid cancer patients treated by (131)I. For this purpose, the dose amounts received by 29 people accompanying patients were measured using thermoluminescence dosimeters. A badge containing three TLD-100 chips was given to each caregiver. The people were asked to wear the badges for 24 days, when they are taking care of the patients...
August 22, 2016: Radiation Protection Dosimetry
Doina Piciu, Claudiu Pestean, Elena Barbus, Maria Iulia Larg, Andra Piciu
BACKGROUND AND AIM: This study aimed at determining whether there is a risk regarding the development of second primary malignancies after patient exposure to the low and medium radioiodine activity used during the treatment of differentiated thyroid cancers (DTC). METHODS: Second primary malignancies that occurred after DTC were detected in 1,990 patients treated between 1970 and 2003. The mean long-term follow-up period was 182 months. RESULTS: Radioiodine I-131was administrated at a mean dose of 63...
2016: Clujul Medical (1957)
Hatice Şakı, Arzu Cengiz, Yakup Yürekli
OBJECTIVE: The aim of this retrospective study is to evaluate the treatment outcomes in patients with toxic nodular goiter (TNG) that received radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size, I-131 dose, underlying etiology and antithyroid drugs on the outcomes of RAIT. METHODS: Two hundred thirty three patients (mean 64±10 years old) with TNG that received RAIT were included in the study. Treatment success was analyzed according to demographic (age and gender) and clinical data (thyroid function tests before and after RAIT, thyroid sonography and scintigraphy, I-131 dose, antithyroid drugs)...
October 5, 2015: Molecular Imaging and Radionuclide Therapy
Gül Ege Aktaş, Halil Turgut Turoğlu, Tanju Yusuf Erdil, Sabahat İnanır, Fuat Dede
OBJECTIVE: Geriatric patient population has special importance due to particular challenges. In addition to the increase in incidence of toxic nodular goiter (TNG) with age, it has a high incidence in the regions of low-medium iodine intake such as in our country. The aim of this study was to evaluate the overall outcome of high fixed dose radioiodine (RAI) therapy, and investigate the particular differences in the geriatric patient population. METHODS: One hundred and three TNG patients treated with high dose I-131 (370-740 MBq) were retrospectively reviewed...
October 5, 2015: Molecular Imaging and Radionuclide Therapy
Marin Prpic, Davor Kust, Ivan Kruljac, Lora Stanka Kirigin, Tomislav Jukic, Nina Dabelic, Ante Bolanca, Zvonko Kusic
BACKGROUND: The purpose of this study was to detect parameters that could serve as predictors of radioactive iodine (I-131) ablation failure in patients with low-risk and intermediate-risk differentiated thyroid carcinoma (DTC). METHODS: Our cohort study included 740 patients with DTC who received postoperative I-131 remnant ablation. Anthropometric, biochemical, and pathohistological parameters were analyzed and correlated with ablation outcome using multivariable logistic regression models...
July 26, 2016: Head & Neck
Johannes Tran-Gia, Susanne Schlögl, Michael Lassmann
: Currently, the validation of multimodal quantitative imaging and absorbed dose measurement is impeded by the lack of suitable, commercially available anthropomorphic phantoms of variable sizes and shapes. To demonstrate the potential of 3D printing techniques for quantitative SPECT/CT imaging, a set of kidney dosimetry phantoms and their spherical counterparts was designed and manufactured with a fused deposition modeling 3D printer. Nuclide-dependent SPECT/CT calibration factors were determined to assess the accuracy of quantitative imaging for internal renal dosimetry...
July 21, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Gopal Pathuri, Andria F Hedrick, Vibhudutta Awasthi, Benjamin D Cowley, Hariprasad Gali
Ortho-[(131)I]iodohippurate [(131)I]OIH (marketed as Hippuran I 131), a gold standard for radionuclide renography, and [(123)I]OIH were in clinical use for decades. Here we radiolabeled OIH with (124)I (a positron emitter) to combine the desirable biological properties of OIH and to enable the use of positron emission tomography (PET) for renography. [(124)I]OIH was synthesized with a slight modification to a previously reported method for the kit preparation of [(123)I]OIH based on the Cu(II) catalyzed isotope-exchange reaction...
September 2016: Applied Radiation and Isotopes
M J Azorín Belda, A Martínez Caballero, G C Figueroa Ardila, M Martínez Ramírez, C A Gómez Jaramillo, J I Dolado Ardit, J Verdú Rico
AIM: Stimulation with recombinant human thyrotropin (rhTSH) increases thyroid radioiodine uptake, and is an aid to (131)I therapy in non-toxic multinodular goitre (MNG). However, there are not many studies using rhTSH prior to (131)I in toxic multinodular goitre to improve hyperthyroidism and compressive symptoms. MATERIAL AND METHOD: A prospective study was conducted on patients with MNG and hyperthyroidism. Patients were recruited consecutively and divided into group I, stimulated with 0...
July 12, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Yan Shengguang, Choi Ji-Eun, He Li Lijuan
BACKGROUND The aim of this study was to compare the success rate of various levels of I-131 activity for use in remnant ablation in low-risk differentiated thyroid cancer. MATERIAL AND METHODS We identified eligible studies in 5 electronic databases up to December 2014 and the reference lists of original studies and review articles were hand searched for additional articles on this topic. Summary relative risks with their 95% confidence intervals were calculated with a random-effects model. Heterogeneity was assessed using I2 statistics...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Guang-da Liu, Run-dong Zhou, Yu-tong Zha, Jing Cai, Jun-qi Niu, Pu-jun Gao, Li-li Liu
Measurement for hemodynamic parameters has always been a hot spot of clinical research. Methods for measuring hemodynamic parameters clinically have the problems of invasiveness, complex operation and being unfit for repeated measurement. To solve the problems, an indicator densitometry analysis method is presented based on near-infrared spectroscopy (NIRS) and indicator dilution theory, which realizes the hemodynamic parameters measured noninvasively. While the indocyanine green (ICG) was injected into human body, circulation carried the indicator mixing and diluting with the bloodstream...
March 2016: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
Naoto Watanabe, Kunihiko Yokoyama, Seigo Kinuya, Hisao Tonami
OBJECTIVE: The purpose of this study was to evaluate the degree of cytological radiation damage to lymphocytes occurring after I-131 metaiodobenzylguanidine (MIBG) therapy as determined by the cytokinesis-blocked micronucleus assay. The chromosomal damage to lymphocytes induced by I-131 in vivo should result in augmentation of the number of cells with micronuclei. METHODS: We studied 15 patients with pheochromocytoma (14/15) or ganglioneuroma (1/15), who were treated initially with 7...
July 9, 2016: Annals of Nuclear Medicine
Burcu Dirlik Serim, Ulku Korkmaz, Unal Can, Gulay Durmus Altun
Radionuclide scintigraphy with I-131 and Tc-99m pertechnetate ((99)mTc04) has been widely used in detecting toxic nodules. Intrathoracic goiter usually presents as an anterior mediastinal mass. Mostly the connection between intrathoracic mass and the cervical thyroid gland is clearly and easily identified occurring as a result of inferior extension of thyroid tissue in the neck, which is called as secondary intrathoracic goiter. Completely separated, aberrant or in other words primary intrathoracic goiters arise as a result of abnormal embryologic migration of ectopic thyroid closely associated with aortic sac and descend into the mediastinum...
July 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Anchisa Kunawudhi, Chetsadaporn Promteangtrong, Chanisa Chotipanich
Thyroid cancer is usually, relatively hypofunctional; most patients with thyroid cancer are clinically euthyroid. The combination of thyroid cancer and thyrotoxicosis is not common. We herein, report a case of follicular thyroid cancer with hyperfunctioning metastasis in a 43-year-old woman who presented with thyrotoxicosis, a cold right thyroid nodule, and low I-131 uptake at the thyroid bed. An additional total body scan with I-131 revealed a large radioiodine avid osteolytic bone metastasis with soft tissue masses and liver metastasis...
July 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
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