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https://www.readbyqxmd.com/read/29165687/investigation-of-the-relationship-between-radiation-dose-and-gene-mutations-and-fusions-in-post-chernobyl-thyroid-cancer
#1
Alexey A Efanov, Alina V Brenner, Tetiana I Bogdanova, Lindsey M Kelly, Pengyuan Liu, Mark P Little, Abigail I Wald, Maureen Hatch, Liudmyla Y Zurnadzy, Marina N Nikiforova, Vladimir Drozdovitch, Kiyohiko Mabuchi, Mykola D Tronko, Stephen J Chanock, Yuri E Nikiforov
Background: Exposure to ionizing radiation during childhood is a well-established risk factor for thyroid cancer. However, the genetic mechanisms of radiation-associated carcinogenesis remain not fully understood. Methods: In this study, we used targeted next-generation sequencing and RNA-Seq to study 65 papillary thyroid cancers (PTCs) from patients in the Ukrainian-American cohort with measurement-based iodine-131 (I-131) thyroid doses received as a result of the Chernobyl accident...
November 18, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29158901/dosing-of-radioactive-iodine-in-end-stage-renal-disease-patient-with-thyroid-cancer
#2
Mallika Bhat, Matty Mozzor, Savneek Chugh, Vamsi Buddharaju, Monica Schwarcz, Guy Valiquette
We describe detailed administration of thyroidal and extrathyroidal doses of radioiodine to a patient with end-stage renal disease on hemodialysis. A thorough description of area under curve measurements in a patient with compromised renal function has rarely been described in the literature. Few publications have described thyroid cancer management of patients on hemodialysis, and we believe our management will aid in patient treatment in the future. Learning points: Scheduling of hemodialysis is important when administering radioactive iodine...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29154258/prediction-of-dose-to-the-relatives-of-patients-treated-with-radioiodine-131-using-neural-networks
#3
Marzieh Ebrahimi, Mohammad Reza Kardan, Vahid Changizi, Seyed Mahdi Hosseini Pooya, Parham Geramifar
In this study, the effective dose to family members and caregivers of 52 thyroid cancer patients who had been treated with radioiodine I-131 was measured to investigate the ability of neural network for predicting the doses to the relatives. Effectiveness of this method to define the relatives who will receive doses more than 1 mSv was evaluated. The effective doses were measured by TLD. The inputs of neural network were 13 different parameters that potentially could affect the dose and the output was dose to the family members...
November 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29125000/salivary-evaluation-in-radioactive-i-131-treated-patients-with-thyroid-carcinoma
#4
Filipe Ivan Daniel, Luiza Dutra Lima, Liliane Janete Grando, Renata Castro, Elke Annegret K Cordeiro, Claudia Regina Dos Santos
BACKGROUND AND OBJECTIVE: radioiodine treatment (I(131)) used to treat thyroid carcinomas produces side effects (sialadenitis, xerostomia, dysphagia and caries susceptibility) reflecting in a poor patient quality of life. This study aimed to evaluate the effect of I(131) on salivary function and possible oral impairment. MATERIAL AND METHODS: Thirty-seven patients undergoing I(131) were submitted to oral examination, answer questions regarding xerostomia/hyposalivation and collect saliva at three moments (M1: 30-45 days before I(131), M2: 1-2 days after I(131) and M3: 7-10 days after treatment)...
November 10, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29099942/phase-1-study-of-high-specific-activity-i-131-mibg-for-metastatic-and-or-recurrent-pheochromocytoma-or-paraganglioma
#5
Richard B Noto, Daniel A Pryma, Jessica Jensen, Tess Lin, Nancy Stambler, Thomas Strack, Vivien Wong, Stanley J Goldsmith
Context: There are no approved therapies for the treatment of metastatic and/or recurrent pheochromocytoma or paraganglioma (PPGL) in the United States. Objective: To determine the maximum tolerated dose (MTD) of high-specific-activity I-131 meta-iodobenzylguanidine (MIBG) for the treatment of metastatic and/or recurrent PPGL. Design: Phase 1, dose escalating study to determine the MTD via a standard 3+3 design; escalating by 37 MBq/kg starting at 222 MBq/kg...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29054450/a-portable-precision-ionization-chamber-the-transfer-ionization-reference-chamber
#6
Frédéric Juget, Youcef Nedjadi, Thierry Buchillier, Teresa Durán, François Bochud, Christian Kottler, Claude Bailat
A portable instrument was developed at the Institute of Radiation Physics (IRA) for on-site radionuclides measurements. It will enable the measurement of short-lived radionuclides in nuclear medicine departments or isotope production centres. The system involves an ionization chamber read directly by an electrometer and it was optimized to ensure a good reproducibility through the selection of an appropriate vial, filling volume and source position in the well chamber, as well as monitoring the external background and performing a detailed uncertainty estimation...
October 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29032880/comparison-of-131-i-activity-measurements-at-the-ncbj-rc-polatom-and-the-enea-inmri-linked-to-the-bipm-sir-system
#7
T Ziemek, M Capogni, G Ratel, R Broda, T Dziel, A Fazio, A Listkowska
A bilateral comparison between ENEA-INMRI (Italy) and NCBJ RC POLATOM (Poland) of (131)I-solution activity measurements was organized in the year 2015 and piloted by POLATOM, which provided the sources for the comparison. The (131)I master solution was standardized independently at both institutes by using Liquid Scintillation Counting and ionization chamber techniques. The (131)I master solution was then sent by POLATOM to the BIPM International Reference System (SIR). The comparison was registered as an EURAMET...
September 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28969240/a-functional-scoring-system-based-on-salivary-gland-scintigraphy-for-evaluating-salivary-gland-dysfunction-secondary-to-131-i-therapy-in-patients-with-differentiated-thyroid-carcinoma
#8
Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Hiroshi Honda
INTRODUCTION: Radioiodine therapy with (131)I ((131)I therapy) after total or near-total thyroidectomy has been established as an effective treatment for Differentiated Thyroid Carcinoma (DTC), but can induce dry mouth symptoms by salivary gland damage and impair the patients' quality of life. AIM: To propose a functional scoring system based on Salivary Gland Scintigraphy (SGS) findings that evaluates development of salivary gland dysfunction secondary to (131)I therapy in patients with DTC...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28929329/somatic-health-effects-of-chernobyl-30-years-on
#9
REVIEW
Maureen Hatch, Elisabeth Cardis
2016 marked the 30th anniversary of the Chernobyl Nuclear Power Plant accident. We and others wrote reviews for the 25th anniversary. Since then, additional papers have appeared and it seems timely to highlight lessons learned. To present, not a systematic review, but a commentary drawing attention to notable findings. We include not only recent reports and updates on previous results, but key findings from prior Chernobyl studies. The dose-dependent increase in Papillary Thyroid Cancer (PTC) following childhood I-131 exposure in Ukraine and Belarus has now been shown to persist for decades...
September 19, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28898346/-treatment-of-hyperthyroidism-with-radioiodine-during-hemodialysis-report-of-one-case
#10
Claudia Hurtado, María Soledad Báez, Anabel Bate, Claudio Opazo, Mauricio Troncoso
Although radioiodine (131-I) can be used as treatment of hyperthyroidism for patients in hemodialysis, its use is limited and the experience is mainly related to differentiated thyroid carcinoma. We report a 58 years old female on hemodialysis with recurrent hyperthyroidism after propylthiouracil treatment. She was successfully treated with 131-I and four months after the intervention her euthyroid state was confirmed. We measured 131-I activity in blood, dialysate liquid and other waste products, as well as patient radiation exposure rates...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28878853/bilateral-renal-metastasis-of-h%C3%A3-rthle-cell-thyroid-cancer-with-discordant-uptake-between-i-131-sodium-iodide-and-f-18-fdg
#11
Apichaya Claimon, Minseok Suh, Gi Jeong Cheon, Dong Soo Lee, E Edmund Kim, June-Key Chung
Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The renal metastatic lesions were clearly demonstrated by (131)I whole body scan (WBS) with SPECT/CT. However, they exhibited false-negative results in (18)F-FDG PET/CT, kidney ultrasonography, and contrast-enhanced CT scan. The findings imply that tumors have low glucose metabolism and are able to accumulate radioiodine, which is not commonly found in the relatively aggressive nature of HCTC...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28864620/individualized-dosimetry-for-theranostics-necessary-nice-to-have-or-counterproductive
#12
REVIEW
Uta Eberlein, Marta Cremonesi, Michael Lassmann
In 2005, the term theragnostics (theranostics) was introduced for describing the use of imaging for therapy planning in radiation oncology. In nuclear medicine, this expression describes the use of tracers for predicting the absorbed doses in molecular radiotherapy and, thus, the safety and efficacy of a treatment. At present, the most successful groups of isotopes for this purpose are (123)I/(124)I/(131)I, (68)Ga/(177)Lu, and (111)In/(86)Y/(90)Y. The purpose of this review is to summarize available data on the dosimetry and dose-response relationships of several theranostic compounds, with a special focus on radioiodine therapy for differentiated thyroid cancer and peptide receptor radionuclide therapy...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28864611/norepinephrine-transporter-as-a-target-for-imaging-and-therapy
#13
REVIEW
Neeta Pandit-Taskar, Shakeel Modak
The norepinephrine transporter (NET) is essential for norepinephrine uptake at the synaptic terminals and adrenal chromaffin cells. In neuroendocrine tumors, NET can be targeted for imaging as well as therapy. One of the most widely used theranostic agents targeting NET is metaiodobenzylguanidine (MIBG), a guanethidine analog of norepinephrine. (123)I/(131)I-MIBG theranostics have been applied in the clinical evaluation and management of neuroendocrine tumors, especially in neuroblastoma, paraganglioma, and pheochromocytoma...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28864610/iodine-symporter-targeting-with-124-i-131-i-theranostics
#14
REVIEW
James Nagarajah, Marcel Janssen, Philipp Hetkamp, Walter Jentzen
Theranostics, a modern approach combining therapeutics and diagnostics, is among the most promising concepts in nuclear medicine for optimizing and individualizing treatments for many cancer entities. Theranostics has been used in clinical routines in nuclear medicine for more than 60 y-as (131)I for diagnostic and therapeutic purposes in thyroid diseases. In this minireview, we provide a survey of the use of 2 different radioiodine isotopes for targeting the sodium-iodine symporter in thyroid cancer and nonthyroidal neoplasms as well as a brief summary of theranostics for neuroendocrine neoplasms and metastatic castration-refractory prostate cancer...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28856527/neonatal-outcomes-following-exposure-in-utero-to-fallout-from-chernobyl
#15
Maureen Hatch, Mark P Little, Alina V Brenner, Elizabeth K Cahoon, Valery Tereshchenko, Ludmyla Chaikovska, Igor Pasteur, Ilya Likhtarov, Andre Bouville, Victor Shpak, Olena Bolshova, Galyna Zamotayeva, Katherine Grantz, Liping Sun, Kiyohiko Mabuchi, Paul Albert, Mykola Tronko
Iodine 131 (I-131), the principal component of nuclear fallout from the Chernobyl accident, concentrates in the thyroid gland and may pose risks to fetal development. To evaluate this, neonatal outcomes following the accident in April of 1986 were investigated in a cohort of 2582 in utero-exposed individuals from northern Ukraine for whom estimates of fetal thyroid I-131 dose were available. We carried out a retrospective review of cohort members' prenatal, delivery and newborn records. The relationships of dose with neonatal anthropometrics and gestational length were modeled via linear regression with adjustment for potentially confounding variables...
August 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28815788/association-between-radioiodine-treatment-for-thyroid-cancer-and-risk-of-stroke
#16
Chun-Yi Lin, Cheng-Li Lin, Yi-Chen Lo, Chia-Hung Kao
BACKGROUND: The purpose of this study was to evaluate the association between radioiodine (I-131) therapy for thyroid cancer and the risk of stroke in Taiwan. METHODS: A total of 10 104 of the patients aged 20 years or older, who were newly diagnosed with thyroid cancer during 2000-2010, were recruited and classified into 2 cohorts according to whether they received I-131 therapy through 1:1 propensity score matching. The cumulative Kaplan-Meier curves for the incidence of stroke in the 2 cohorts were compared using the log-rank test...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#17
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28757700/brachytherapy-and-anterior-segment-imaging-in-iris-melanoma
#18
Jin Soo Andy Song, Adam A Dmytriw, Hesham Lakosha
Ultrasound biomicroscopy (UBM) remains a potent tool in the diagnosis and characterization of uveal lesions. In the setting of malignancy, it can confirm both placement of and response to brachytherapy. We present a case of iris melanoma with aggressive BAP-1 mutation, treated successfully with I-131 brachytherapy which was both characterized and followed with UBM and thereafter discuss the current state of these modalities.
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28755565/automatic-plume-episode-identification-and-cloud-shine-reconstruction-method-for-ambient-gamma-dose-rates-during-nuclear-accidents
#19
Xiaole Zhang, Wolfgang Raskob, Claudia Landman, Dmytro Trybushnyi, Christoph Haller, Hongyong Yuan
Ambient gamma dose rate (GDR) is the primary observation quantity for nuclear emergency management due to its high acquisition frequency and dense spatial deployment. However, ambient GDR is the sum of both cloud and ground shine, which hinders its effective utilization. In this study, an automatic method is proposed to identify the radioactive plume passage and to separate the cloud and ground shine in the total GDR. The new method is evaluated against a synthetic GDR dataset generated by JRODOS (Real Time On-line Decision Support) System and compared with another method (Hirayama, H...
November 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28742421/comparison-of-30-mci-and-50-mci-i-131-doses-for-ablation-of-thyroid-remnant-in-papillary-thyroid-cancer-patients
#20
Xiao Yue Cai, Niranjan Vijayaratnam, Alexander J B McEwan, Rebecca Reif, Donald W Morrish
PURPOSE OF THE STUDY: To compare efficacy of thyroid remnant ablation using 30 mCi or 50 mCi 131-I in papillary thyroid cancer patients. MATERIALS AND METHODS: Five hundred and fifteen consecutive patients with Tumor-Node-Metastasis (TNM) stages T1-T3 N1/N0/NX receiving either 30 mCi or 50 mCi I-131 were analyzed for the effectiveness of remnant ablation using rhTSH-stimulated serum thyroglobulin. One hundred and five consecutive patients receiving 100 mCi I-131 were analyzed for the incidence of radiation thyroiditis and sialadenitis...
July 25, 2017: Endocrine Research
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