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https://www.readbyqxmd.com/read/29625443/comprehensive-molecular-screening-in-chinese-usher-syndrome-patients
#1
Tengyang Sun, Ke Xu, Yanfan Ren, Yue Xie, Xiaohui Zhang, Lu Tian, Yang Li
Purpose: Usher syndrome (USH) refers to a group of autosomal recessive disorders causing deafness and blindness. The objectives of this study were to determine the mutation spectrum in a cohort of Chinese patients with USH and to describe the clinical features of the patients with mutations. Methods: A total of 119 probands who were clinically diagnosed with USH were recruited for genetic analysis. All probands underwent ophthalmic examinations. A combination of molecular screening methods, including targeted next-generation sequencing, Sanger-DNA sequencing, and multiplex ligation probe amplification assay, was used to detect mutations...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29620233/a-frameshift-mutation-in-the-chm-gene-causes-choroideremia-with-acute-angle%C3%A2-closure-glaucoma
#2
Pingbo Ouyang, Yun Li, Feng Zhang, Chengzhang Zhu, Beiji Zou, Jianlan Le, Lusi Zhang
Choroideremia is an X‑linked recessive chorioretinal degenerative disease that is characterized by progressive centripetal loss of the photoreceptor, retinal pigment epithelium (RPE), and choriocapillaris layers. The CHM gene [choroideremia (Rab escort protein 1)] has been identified as the pathogenic gene in choroideremia. The aim of the present study was to describe the clinical and genetic characteristics of a family with choroideremia family. In the present study, a family with choroideremia presenting with serious chorioretinal atrophy and pigment proliferation, shallow anterior chambers, angle closure and high intraocular pressure (IOP) were recruited...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29600606/-application-of-evidence-based-rapid-review-in-studying-nephrotoxicity-of-tripterygium-wilfordii-preparation
#3
Xue Feng, Sai-Nan Fang, Yu-Xin Gao, Jian-Ping Liu, Wei Chen
To investigate the feasibility of applying the evidence-based rapid review in studying the nephrotoxicity of Tripterygium wilfordii preparation. We used four methods in relevant studies on the nephrotoxicity of T. wilfordii preparation. The first method had no limitation on any search terms, which was a traditional approach to retrieve systematic reviews. The second method limited the relevant search terms of T. wilfordii preparation to "all of CHMs containing T. wilfordii preparation approved by CFDA"...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29600604/-evidence-based-evaluation-on-safety-of-tripterygium-wilfordii-preparations
#4
Xue Feng, Sai-Nan Fang, Yu-Xin Gao, Jian-Ping Liu, Wei Chen
The study was aimed to conduct an evidence-based evaluation on the safety of Tripterygium wilfordii(TW) preparations through a method combined bibliometrics research with evidence-based evaluation research, to provide evidence-based safety information of the TW preparations(nephrotoxicity) for the government decision-making and clinical application, and to provides methods and suggestions for evaluating nephrotoxicity of Chinese herbal medicine(CHM) in the future. We searched relevant databases at home and abroad systematically, and six Chinese and English databases including CNKI, SinoMed, VIP, WanFang, PubMed, and Cochrane library were comprehensively searched...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29595636/evidence-based-practice-guideline-of-chinese-herbal-medicine-for-primary-open-angle-glaucoma-qingfeng-neizhang
#5
Yingxin Yang, Qiu-Yan Ma, Yue Yang, Yu-Peng He, Chao-Ting Ma, Qiang Li, Ming Jin, Wei Chen
BACKGROUND: Primary open angle glaucoma (POAG) is a chronic, progressive optic neuropathy. The aim was to develop an evidence-based clinical practice guideline of Chinese herbal medicine (CHM) for POAG with focus on Chinese medicine pattern differentiation and treatment as well as approved herbal proprietary medicine. METHODS: The guideline development group involved in various pieces of expertise in contents and methods. Authors searched electronic databases include CNKI, VIP, Sino-Med, Wanfang data, PubMed, the Cochrane Library, EMBASE, as well as checked China State Food and Drug Administration (SFDA) from the inception of these databases to June 30, 2015...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29574941/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-skin-patch-of-chinese-herbal-medicine-for-patients-with-acute-gouty-arthritis
#6
REVIEW
Huiru Wang, Qiang Fu, Zhe Liu, Menglin Li, Shuangqing Zhai
AIMS: To evaluate the evidence of the effectiveness and safety of Chinese herbal medicine skin-patches for patients with acute gouty arthritis. BACKGROUND: Acute gouty arthritis is a problem that can limit the level of activity and impair the quality of life. In China, many clinical studies have demonstrated that skin-patches of Chinese herbal medicines benefit patients with acute gouty arthritis. However, the reported clinical effects vary. DESIGN: A systematic review and meta-analysis of randomized controlled trials...
March 25, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29562309/diagnostic-utility-of-twist1-ki-67-and-e-cadherin-in-diagnosing-molar-gestations-and-hydropic-abortions
#7
Rabab A Moussa, Ahmed N Eesa, Zeinab F Abdallah, Ayman Abdelmeged, Ahmed Mahran, Haitham Bahaa
Objectives: This study aims to assess whether the expression of Twist1, Ki-67, and E-cadherin can guide the differential diagnosis of complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and hydropic abortion (HA). Methods: Differential expression of Twist1, Ki-67, and E-cadherin was analyzed in gestational products from 55 cases of CHM, PHM, and HA using immunohistochemistry. Prior to analysis, the studied cases were confirmed for their diagnosis by flow cytometric assessment of DNA ploidy and p57 immunostaining...
March 19, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29555028/molecular-genetics-%C3%A2-characterization-and-homology-modeling-of-the-chm-gene-mutation-a-study-on-its-association-with-choroideremia
#8
REVIEW
Saber Imani, Iqra Ijaz, Marzieh Dehghan Shasaltaneh, Shangyi Fu, Jingliang Cheng, Junjiang Fu
Choroideremia (CHM) is a rare form of X-linked chorioretinal dystrophy that is caused by mutations in the CHM gene. Mutations in the Rab escort protein-1 (REP-1), an ubiquitously encoded protein of the CHM gene, lead to prenylation and vesicle trafficking deficiency in the protein, resulting in the progressive degeneration of choriocapillaris, retinal pigment epithelium (RPE), and photoreceptors. Despite previous studies concerning this disease, no effective diagnostic tests or established therapeutic interventions currently exist for CHM...
January 2018: Mutation Research
https://www.readbyqxmd.com/read/29551646/promotion-of-quality-standard-of-chinese-herbal-medicine-by-the-integrated-and-efficacy-oriented-quality-marker-of-effect-constituent-index
#9
Yin Xiong, Yupiao Hu, Fan Li, Lijuan Chen, Qin Dong, Jiabo Wang, Elizabeth A Gullen, Yung-Chi Cheng, Xiaohe Xiao
BACKGROUND: Multiple constituents have been applied currently as markers to control the quality of Chinese herbal medicine (CHM). However, those constituents are isolated from each other, failed to present their contribution differences to the bioeffect of CHM. Besides, a CHM for different clinic uses is often controlled by the same quality marker (Q-marker), which cannot correlate its efficacies differentially. PURPOSE: The study aims to promote the quality standard of CHM by the integrated and efficacy-oriented Q-marker of Effect-constituent Index (ECI)...
March 7, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29543633/vascular-alterations-revealed-with-optical-coherence-tomography-angiography-in-patients-with-choroideremia
#10
Maurizio Battaglia Parodi, Alessandro Arrigo, Robert E MacLaren, Emanuela Aragona, Lisa Toto, Rodolfo Mastropasqua, Maria Pia Manitto, Francesco Bandello
PURPOSE: Choroideremia is a rare degenerative retinal disease that causes incurable blindness. It occurs as a result of the deficiency of the X-linked CHM gene, which encodes the Rab escort protein 1 (REP1). Gene therapy has been developed to treat CHM using adeno-associated viral vectors and is currently undergoing clinical trials. Expression of the CHM gene is ubiquitous throughout the retina, and it is therefore important to identify which retinal layers are affected in the disease process...
March 14, 2018: Retina
https://www.readbyqxmd.com/read/29530610/effects-of-chinese-herbal-medicine-on-hyperlipidemia-and-the-risk-of-cardiovascular-disease-in-hiv-infected-patients-in-taiwan
#11
Fuu-Jen Tsai, Te-Mao Li, Chi-Fung Cheng, Yang-Chang Wu, Chih-Ho Lai, Tsung-Jung Ho, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Due to the development of antiretroviral therapy (ART), HIV/AIDS is now regarded as a treatable chronic disease. Chinese herbal medicine (CHM) is a type of complementary and alternative medicine (CAM) that has been widely applied in the healthcare system in Taiwan. AIM OF THE STUDY: The aim of this study was to investigate the frequency of use and patterns of prescription for the CHM-based treatment of HIV-infected patients and to assess the long-term effects of CHM on hyperlipidemia and cardiovascular disease events in these patients...
March 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29515648/analysis-of-the-impact-of-configuration-of-the-stabilisation-system-for-femoral-diaphyseal-fractures-on-the-state-of-stresses-and-displacements
#12
Jakub J Słowiński, Konrad Kudłacik
Introduction: The treatment of femoral diaphyseal fractures by intramedullary nailing has become a common procedure in orthopaedic surgery. The purpose of this numerical simulation was to present how the changes in configuration of the stabilisation system can affect the stress and displacement state in the bone tissue and implanted device. Material and Methods: The numerical comparison of the stabilisation variants for the type 32-A2 femoral diaphyseal fracture (according to the AO classification) performed by using the Charfix2 (ChM®) anatomical nail locked in a number of chosen ways...
2018: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/29477553/does-a-human-chorionic-gonadotropin-level-of-over-20-000-iu-l-four-weeks-after-uterine-evacuation-for-complete-hydatidiform-mole-constitute-an-indication-for-chemotherapy-for-gestational-trophoblastic-neoplasia
#13
Antonio Braga, Andressa Biscaro, Jessye Melgarejo do Amaral Giordani, Maurício Viggiano, Kevin M Elias, Ross S Berkowitz, Michael J Seckl
OBJECTIVE: To evaluate whether a human chorionic gonadotropin (hCG) level ≥20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole (CHM) is an appropriate indicator for initiating chemotherapy for the treatment of gestational trophoblastic neoplasia (GTN). STUDY DESIGN: Historical database review of 1228 women with CHM who received treatment and follow-up between January 2000 and June 2013 at four Brazilian trophoblastic disease centers...
February 15, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29458918/management-of-ifn-beta-induced-flu-like-symptoms-with-chinese-herbal-medicine-in-a-patient-with-multiple-sclerosis-a-case-report
#14
Li-Wen Lee, Hung-Jen Lin, Sheng-Teng Huang
OBJECTIVE: The purpose of this case report was to elucidate how Chinese herbal medicine (CHM) was used safely in this patient undergoing interferon beta (IFNβ-1a) treatment and was associated with reduction in the side effects the patient had experienced when using IFNβ-1a treatment alone. CLINICAL FEATURES AND OUTCOME: A 30-year-old man was diagnosed with MS in December 2014. For two years, he suffered from severe flu-like symptoms as side effects of IFNβ-1a treatment...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29458917/chinese-herbal-medicine-to-treat-urolithiasis-in-a-patient-with-right-flank-pain-and-hematuria-a-case-report
#15
Hsiang-Chun Lai, Hung-Jen Lin, Sheng-Teng Huang
OBJECTIVE: Urolithiasis is a common medical condition affecting the urinary tract. Typical symptoms reported by patients include colic pain and hematuria. Some patients may undergo surgical intervention or lithotripsy to remove the stones. In this case, we demonstrated that Chinese herbal medicine (CHM) was an effective modality to remove stones in a patient with urolithiasis. CLINICAL FEATURES AND OUTCOME: A 47-year-old man suffered from right flank pain and hematuria for three months and was diagnosed with an upper third ureteral stone obstruction with right hydronephrosis...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29458875/clinical-and-genetic-epignetic-aspects-of-recurrent-hydatidiform-mole-a-review-of-literature
#16
REVIEW
Najmeh Moein-Vaziri, Jafar Fallahi, Bahia Namavar-Jahromi, Majid Fardaei, Mozhdeh Momtahan, Zahra Anvar
Hydatidiform Mole (HM) is the most common form of Gestational Trophoblastic Disease (GTD), defined by hyper-proliferation of trophoblastic cells. HM is typified as abnormal proliferation of extraembryonic trophoblastic (placental) tissues and failure of embryonic tissues development and is the only GTD with Mendelian inheritance, which can reoccur in different pregnancies. Moles are categorized into Complete Hydatidiform Moles (CHM) or Partial Hydatidiform Moles (PHM) and a rare familial trait, which forms a CHM and despite having androgenetic pattern, shows normal biparental inheritance, conceived from one sperm and egg...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29451409/temporal-trends-in-incidence-and-outcome-of-hydatidiform-mole-a-retrospective-cohort-study
#17
Urika Joneborg, Yasin Folkvaljon, Nikos Papadogiannakis, Mats Lambe, Lena Marions
BACKGROUND: Reported incidence rates of hydatidiform mole (HM) show wide geographic and temporal variations, making reliable international comparisons difficult. The aim of the current study was to examine temporal trends in the incidence of HM and post-molar gestational trophoblastic neoplasia (GTN) in Stockholm County. MATERIAL AND METHODS: Data of all women with a diagnosis of HM in Stockholm County 1991-2010 was collected. The incidence of HM was assessed both in relation to number of births and viable conceptions (births and pregnancy terminations)...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29442745/-okra-abelmoschus-esculentus-plant-extract-assisted-combustion-synthesis-and-characterization-studies-of-spinel-znal%C3%A2-o%C3%A2-nano-catalysts
#18
P Bhavani, A Manikandan, P Paulraj, A Dinesh, M Durka, S Arul Antony
Spinel ZnAl2O4 nano-catalysts were synthesized by a simple, economical and eco-friendly microwave irradiation (MIM) and conventional heating methods (CHM), using metal nitrates and Okra (Abelmoschus esculentus) plant extract, which play a dual role of both oxidizing and reducing nature. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) and selected area electron diffraction (SAED) pattern results were confirmed that the samples have a single-phase cubic spinel structure with high crystalline nature of ZnAl2O4...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439346/chinese-herbal-medicine-for-vascular-dementia-a-systematic-review-and-meta-analysis-of-high-quality-randomized-controlled-trials
#19
Qing-Qing Xu, Chun-Shuo Shan, Yong Wang, Yi-Hua Shi, Qi-Hao Zhang, Guo-Qing Zheng
BACKGROUND: Vascular dementia (VaD) is the second common form of dementia and Chinese herbal medicine (CHM) has been used for aging-related disorders for thousands of years. However, there is still a lack of scientific evidence using CHM for VaD. OBJECTIVE: To conduct a systematic review to assess the current evidence available for the effectiveness and safety of CHM for VaD. METHODS: Six databases were searched for high-quality randomized-controlled clinical trials that met the requirements of at least 4 of the 7 domains of the Cochrane risk of bias tool from their inception to February 2017...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29436108/a-fetus-coexisting-with-a-complete-hydatidiform-mole-with-trisomy-9-of-maternal-origin
#20
Anita Sik Yau Kan, Elizabeth Tak Kwong Lau, Chun Hong So, Wan Pang Chan, Wing Cheuk Wong, Kam Cheong Lee, Mark D Pertile, Mary Hoi Yin Tang
A complete hydatidiform mole (CHM) coexisting with a viable fetus is a rare finding in pregnancies. Accurate diagnosis often relies on ultrasonographic, histopathological and molecular techniques in the definite diagnosis. To the best of our knowledge, a liveborn fetus coexisting with CHM with trisomy 9 has not been described. The use of molecular genotyping and immunohistochemical laboratory investigations enabled the CHM to be fully characterized. Postzygotic diploidization of a triploid conception arising from dispermy is the proposed mechanism of its formation...
February 13, 2018: Journal of Obstetrics and Gynaecology Research
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