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https://www.readbyqxmd.com/read/29213243/mechanism-of-chinese-medicine-herbs-effects-on-chronic-heart-failure-based-on-metabolic-profiling
#1
Kuo Gao, Huihui Zhao, Jian Gao, Binyu Wen, Caixia Jia, Zhiyong Wang, Feilong Zhang, Jinping Wang, Hua Xie, Juan Wang, Wei Wang, Jianxin Chen
Chronic heart failure (CHF) is a major public health problem in huge population worldwide. The detailed understanding of CHF mechanism is still limited. Zheng (syndrome) is the criterion of diagnosis and therapeutic in Traditional Chinese Medicine (TCM). Syndrome prediction may be a better approach for understanding of CHF mechanism basis and its treatment. The authors studied disturbed metabolic biomarkers to construct a predicting mode to assess the diagnostic value of different syndrome of CHF and explore the Chinese herbal medicine (CHM) efficacy on CHF patients...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29200714/simultaneous-determination-of-ten-constituents-in-chaiqin-qingning-capsule-by-high-performance-liquid-chromatography-coupled-with-triple-quadrupole-mass-spectrometry
#2
Ting Yu Li, Xiao Kui Huo, Lu Zheng, Chao Wang, Hai Jian Cong, Ting Xiang, Lin Zhang, Bao Jing Zhang, Shan Shan Huang, Bin Wu, Xin Yu Li
Background: Chaiqin Qingning Capsule (CQQNC) was a prescription of Traditional Chinese Medicine with the effects of clearing away heat and removing toxin, harmonizing the exterior and interior, it was widely used in Asian, for example, China and Japan, different batches of the raws materials and different processing time may be the vital factor which raised a challenge to control the quality of the CQQNC. Experimental Methods: In this experiment, a high-performance liquid chromatography-mass spectrometry/MS (HPLC-MS/MS) method was developed to simultaneously determine ten bioactive components for the quality control of CQQNC...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29178676/chinese-herbal-medicine-to-treat-allergic-rhinitis-evidence-from-a-meta-analysis
#3
Xu Zhang, Feng Lan, Yuan Zhang, Luo Zhang
PURPOSE: Chinese herbal medicine (CHM) has been widely used in China to treat allergic rhinitis (AR). However, several studies have produced conflicting data with regard to the efficacy of the medicine. Our aim was to perform a meta-analysis of randomized clinical trials (RCTs) to evaluate the relative efficacy of CHM. METHODS: We systematically searched the PubMed, Medline, and Springer electronic databases up to March 2017 for RCTs comparing the efficacy of CHM versus placebo for the treatment of patients with AR...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29171222/-molecular-regulative-mechanisms-of-aging-and-interventional-effects-of-chinese-herbal-medicine
#4
REVIEW
Bu-Hui Liu, Yi-Huang Gu, Yue Tu, Wei-Ming He, Wei Wu, Ying-Lu Liu, Zi-Yue Wan, Yi-Gang Wan
Aging is a gradual process during the loss of functions in cells,organs and tissues by time. The molecular mechanisms of aging-related theories include the classical ones such as telomere,oxygen radical and nonenzymatic glycosylation,as well as the newly proposed ones such as DNA methylation,mitochondrial DNA (mtDNA)and autophagy. The latest study showed the anti-aging effect of autophagy in hematopoietic stem cells. In recent years,based on the molecular regulative mechanisms of aging,a number of the promising anti-aging drugs have been found,including nicotinamide mononucleotide(NMN)and FOXO4-DRI,a peptide of anti-aging...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29163845/improved-medical-expenditure-and-survival-with-integration-of-traditional-chinese-medicine-treatment-in-patients-with-heart-failure-a-nationwide-population-based-cohort-study
#5
Ming-Yen Tsai, Wen-Long Hu, Jen-Huai Chiang, Yu-Chuen Huang, Shih-Yu Chen, Yu-Chiang Hung, Yung-Hsiang Chen
Background: No previous studies have evaluated the effects of traditional Chinese medicine (TCM) treatment on patients with heart failure (HF). Hence, in this study, we determined whether TCM treatment affects the healthcare burden and survival of HF patients. Methods: Samples were retrieved from the registry of catastrophic illness patients of the Taiwan National Health Insurance Research Database (NHIRD). Based on a frequency (1:1) matched case-control design, patients with HF between 2000 and 2010 were designated as cases (TCM users) and controls (non-TCM users)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155500/chinese-medicine-for-diabetic-kidney-disease-in-china
#6
REVIEW
Yumin Wen, Meihua Yan, Bingxuan Zhang, Ping Li
Diabetic kidney disease (DKD) is a major global public health concern due to its high prevalence and mortality, and high healthcare cost. Conventional Western therapies for DKD fail to provide favourable efficacy. Chinese medicine (CM) has been widely used to combat DKD in China and other Asian countries. The clinical effects and mechanism of CM in treating DKD have not been fully elucidated. This review summarizes current knowledge of CM therapeutic modalities for DKD, especially Chinese herbal medicine (CHM), and potential mechanisms...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29148533/identifying-characteristic-features-of-the-retinal-and-choroidal-vasculature-in-choroideremia-using-optical-coherence-tomography-angiography
#7
A Abbouda, A M Dubis, A R Webster, M Moosajee
PurposeUsing optical coherence tomography angiography (OCTA) to investigate the area with flow in the superficial retinal vessel network (SVRN) and choriocapillaris (CC) layer among male subjects with choroideremia (CHM), female carriers, and normal controls to identify vascular changes.Patients and methodsImages of SRVN and CC layer were acquired in 9 affected males, 5 female carriers, and 14 age- and gender-matched controls using the Angiovue software of the RTVue XR Avanti.ResultsThe mean age was 33 years for affected male CHM patients (median 30 years), 46 years for female carriers (median 53 years), and 39 years for controls (median 38...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29121880/comparison-of-different-therapeutic-strategies-for-complete-hydatidiform-mole-in-women-at-least-40%C3%A2-years-old-a-retrospective-cohort-study
#8
Peng Zhao, Qinqing Chen, Weiguo Lu
BACKGROUND: There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the above-mentioned methods. The objective of this study was to evaluate the effectiveness of these therapeutic strategies in preventing post-molar gestational trophoblastic neoplasia (GTN) pertaining to patients with CHM who were at least 40 years old...
November 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29100936/characteristics-of-chinese-herbal-medicine-usage-and-its-effect-on-survival-of-lung-cancer-patients-in-taiwan
#9
Te-Mao Li, Yang-Hao Yu, Fuu-Jen Tsai, Chi-Fung Cheng, Yang-Chang Wu, Tsung-Jung Ho, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
ETHNOPHARMACOLOGICAL RELEVANCE: In Taiwan, lung cancer remains one of the deadliest cancers. Survival of lung cancer patients remains low, ranging from 6% to 18%. Studies have shown that Chinese herbal medicine (CHM) can be used to induce cell apoptosis and exhibit anti-inflammatoryanti-inflammatory activities in cancer cells. AIM OF THE STUDY: This study aimed to investigate the frequencies and patterns of CHM treatment for lung cancer patients and the effect of CHM on their survival probability in Taiwan...
October 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29095272/treatment-of-triple-negative-breast-cancer-with-chinese-herbal-medicine-a-prospective-cohort-study-protocol
#10
MULTICENTER STUDY
Hui Meng, Nan Peng, Mingwei Yu, Xu Sun, Yunfei Ma, Guowang Yang, Xiaomin Wang
INTRODUCTION: Triple-negative breast cancer (TNBC) is featured with the biological properties of strong aggressive behaviors, rapid disease progression, high risk of recurrence and metastasis, and low disease free survival. Patients with this tumor are insensitive to the endocrine therapy and target treatment for HER-2; therefore, chemotherapy is often used as routine treatment in clinical. Because of the fact that a considerable number of patients seek for Chinese herbal medicine (CHM) treatment after operation and chemotherapy and (or) radiotherapy, it is thus need to evaluate the correlation between Chinese herbal medicine treatment and prognosis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093287/stilbene-glucoside-a-putative-sleep-promoting-constituent-from-polygonum-multiflorum-affects-sleep-homeostasis-by-affecting-the-activities-of-lactate-dehydrogenase-and-salivary-alpha-amylase
#11
Qian Wei, Guang Ta, Wenjing He, Wei Wang, Qiucheng Wu
Chinese herbal medicine (CHM) has been used for treating insomnia for centuries. The most used CHM for insomnia was Polygonum multiflorum. However, the molecular mechanism for CHM preventing insomnia is unknown. Stilbene glucoside (THSG), an important active component of P. multiflorum, may play an important role for treating insomnia. To test the hypothesis, Kunming mice were treated with different dosages of THSG. To examine the sleep duration, a computer-controlled sleep-wake detection system was implemented...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29092932/a-galaxy-implementation-of-next-generation-clustered-heatmaps-for-interactive-exploration-of-molecular-profiling-data
#12
Bradley M Broom, Michael C Ryan, Robert E Brown, Futa Ikeda, Mark Stucky, David W Kane, James Melott, Chris Wakefield, Tod D Casasent, Rehan Akbani, John N Weinstein
Clustered heatmaps are the most frequently used graphics for visualization of molecular profiling data in biology. However, they are generally rendered as static, or only modestly interactive, images. We have now used recent advances in web technologies to produce interactive "next-generation" clustered heatmaps (NG-CHM) that enable extreme zooming and navigation without loss of resolution. NG-CHMs also provide link-outs to additional information sources and include other features that facilitate deep exploration of the biology behind the image...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29084330/characterizing-the-natural-history-of-visual-function-in-choroideremia-using-microperimetry-and-multimodal-retinal-imaging
#13
RANDOMIZED CONTROLLED TRIAL
Jasleen K Jolly, Kanmin Xue, Thomas L Edwards, Markus Groppe, Robert E MacLaren
Purpose: Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (BCVA), microperimetry and multimodal imaging. Methods: Fifty-six consecutive CHM patients attending Oxford Eye Hospital were examined with BCVA, 10-2 microperimetry, optical coherence tomography, and fundus autofluorescence (AF)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29045269/choroideremia-associated-with-a-novel-synonymous-mutation-in-gene-encoding-rep-1
#14
Jesse D Sengillo, Winston Lee, Mathieu F Bakhoum, Galaxy Y Cho, John P-W Chiang, Stephen H Tsang
PURPOSE: To report a novel synonymous mutation in CHM and the associated phenotype in an affected man and carrier mother. METHODS: Case report. RESULTS: A 34-year-old man with a long history of progressive night blindness and visual field constriction was diagnosed with choroideremia based on ocular examination and multimodal retinal imaging. Extensive chorioretinal degeneration was noted on spectral domain optical coherence tomography and fundus autofluorescence imaging...
October 17, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29027529/-twin-pregnancy-with-complete-hydatidiform-mole
#15
I N Voloshchuk, I V Barinova, N I Kondrikov, R A Barto
The paper describes a case of twin pregnancy with complete hydatidiform mole (CHM). According to the data available in the literature, the concurrence of CHM with a normal placenta and a viable fetus occurs in 1 per 20,000-100,000 pregnancies, requires a differential diagnosis with partial hydatidiform mole and placental mesenchymal dysplasia, and is characterized by a high rate of complications. In this concurrence, the frequency of persistent trophoblastic disease is as high as 50%. In this case, the pregnancy ended in a spontaneous abortion at 16-17 weeks of pregnancy...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28986937/effects-of-chinese-herbal-medicine-and-cold-exposure-on-plasma-glucose-leucine-and-energy-metabolism-in-sheep
#16
X Liang, J Jin, X Bi, M Kamruzzaman, T Kudo, H Sano
An experiment was carried out to assess the feeding effect of Chinese herbal medicine on N balance, ruminal fermentation characteristics, kinetics of plasma glucose, leucine and energy metabolism in sheep kept at thermoneutral environment (23°C) or exposed to cold (2-4°C). Four sheep were subjected to either mixed hay (MH-diet) or hay supplemented with 2% of a traditional nourishing Chinese herbal medicine mixture (Astragalus root, Angelica root and Atractylodes rhizome; CHM-diet) over two 23-day periods using a crossover design...
October 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28983591/chondromodulin%C3%A2-i-suppresses-tumorigenesis-of-human-osteosarcoma-cells
#17
Xiangbo Lin, Lijun Wang, Faming Wang
Osteosarcoma is the most common type of bone cancer, and accounts for ~3% of cancers that occurring in children. Chondromodulin‑I (ChM-I) is a 25 kDa glycoprotein that is expressed mainly in cartilage. ChM-I demonstrates anti‑angiogenic activity and has been suggested to inhibit endothelial cells from invading cartilage, and then has been shown to be an inhibitor of tumorigenesis. However, it remains unclear if ChM‑I has any direct anti‑tumorigenesis role on osteosarcoma. Therefore, the present study aimed to identify whether ChM‑I has any direct inhibit effect on human osteosarcoma cells...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28974845/challenges-in-the-routine-praxis-diagnosis-of-hydatidiform-mole-a-tertiary-health-center-experience
#18
Melisa Lelic, Zlatan Fatusic, Ermina Iljazovic, Suada Ramic, Sergije Markovic, Selma Alicelebic
INTRODUCTION: Hydatidiform moles (HM), presenting as complete (CHM) and partial (PHM) form, are rare pregnancy disorder. Diagnosis is based on clinical presentation, ultrasound imaging findings and pathological examination of products of conception. Protein p57, encoded by CKDN1C gene, is paternally imprinted and maternally expressed gene and provides quick insight in genetic basis of HM and allows distinction of CHM from all other conceptions. compare the preevacuational and pathohistological diagnosis with outcome of p57 immunostaining...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28970733/definition-of-colorectal-anastomotic-leakage-a-consensus-survey-among-dutch-and-chinese-colorectal-surgeons
#19
Stefanus J van Rooijen, Audrey Chm Jongen, Zhou-Qiao Wu, Jia-Fu Ji, Gerrit D Slooter, Rudi Mh Roumen, Nicole D Bouvy
AIM: To determine the level of consensus on the definition of colorectal anastomotic leakage (CAL) among Dutch and Chinese colorectal surgeons. METHODS: Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL, and regarding clinical and radiological diagnosis of the complication. RESULTS: Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28969009/effects-of-chinese-herbal-medicines-on-the-occurrence-of-diabetic-retinopathy-in-type-2-diabetes-patients-and-protection-of-arpe-19-retina-cells-by-inhibiting-oxidative-stress
#20
Fuu-Jen Tsai, Te-Mao Li, Cheng-Hang Ko, Chi-Fung Cheng, Tsung-Jung Ho, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Ju-Pi Li, Shao-Mei Huang, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (P < 0...
September 8, 2017: Oncotarget
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