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https://www.readbyqxmd.com/read/28339712/effect-of-chinese-herbal-medicine-treatment-on-plasma-lipid-profile-and-hepatic-lipid-metabolism-in-hetian-broiler
#1
Z Xie, J Zhang, S Ma, X Huang, Y Huang
The purpose of this study was to investigate whether adding a Chinese herbal hedicine (CHM, including astragalus membranaceus, codonopsis pilosula, poria cocos, bighead atractylodes rhizome, fructus crataegi, folium epimedii, radix saposhnikoviae, and pericarpium citri reticulatae) diet has effects on lipid metabolism in the liver of the broiler. Six-hundred-thirty Hetian broilers were divided into 3 groups including base diet (control), 0.3%, or 1% CHM diets, for 130 days. The results showed that CHM treatment significantly increased the slaughter performance...
February 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28330722/the-use-of-chinese-herbal-medicine-as-an-adjuvant-therapy-to-reduce-incidence-of-chronic-hepatitis-in-colon-cancer-patients-a-taiwanese-population-based-cohort-study
#2
Tsai-Hui Lin, Hung-Rong Yen, Jen-Huai Chiang, Mao-Feng Sun, Hen-Hong Chang, Sheng-Teng Huang
ETHNOPHARMACOLOGICAL RELEVANCE: There is a decided lack of in-depth studies to evaluate the effectiveness of Chinese Herbal Medicine (CHM) as an adjuvant therapy on the incidence of chronic hepatitis in patients with colon cancer. AIM OF THE STUDY: The aim of this study is to assess whether CHM treatment decreased the incidence of chronic hepatitisin colon cancer patients who received conventional Western medical treatment. MATERIALS AND METHODS: A Taiwanese nationwide population-based study of colon cancer patients receiving Western medicine treatment in conjunction with CHM treatment, using data provided by the National Health Insurance (NHI) Research Database, was conducted...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28325576/raman-spectroscopy-in-quality-control-of-chinese-herbal-medicine
#3
Dan-Dan Chen, Xiao-Fang Xie, Hui Ao, Ji-Lei Liu, Cheng Peng
BACKGROUND: Chinese herbal medicine (CHM) is of noteworthy international interest due to its potential impact on healthcare and manifests numerous opportunities for new drug development. However, solid scientific evidence is still lacking regarding the safety, efficacy, and quality of CHM-derived medicines. Success in the modernization and globalization of CHM is heavily dependent on the achievements in advanced analytical techniques for in-line checks of CHM quality. Raman spectroscopy has become increasingly valued as an analytical technique in the pharmaceutical sector because it can provide a detailed chemical fingerprint...
March 16, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28302029/in-silico-adme-studies-for-new-drug-discovery-from-chemical-compounds-to-chinese-herbal-medicines
#4
Guojun Yan, Xiaobing Wang, Zhou Chen, Xianhui Wu, Jinhuo Pan, Yushen Huang, Gang Wan, Zhaogang Yang
Nowadays, in-silico tools are widely used to provide the potential structure of the metabolites formed depending on the site of metabolism. These methods can also highlight the molecular moieties that help to direct the molecule into the cytochrome cavity so that the site of metabolism is in proximity to the catalytic center. In this mini-review, we summarized three aspects of the in-silico methods in the application of prediction the ADME (absorption, distribution, metabolism and excretion) properties of compounds: structure-based approaches for predicting molecular modeling of drug metabolizing enzymes; in-silico metabolite prediction; and pharmacophore models for analysis substrate specificity...
March 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28276959/how-should-worsening-in-osteoarthritis-be-defined-development-and-initial-validation-of-preliminary-criteria-for-clinical-worsening-in-knee-and-hip-osteoarthritis
#5
Eam Mahler, A A den Broeder, T G Woodworth, Vjjf Busch, F H van den Hoogen, Jwj Bijlsma, Chm van den Ende
OBJECTIVES: There is a need to define and validate measures of clinical worsening in knee and hip osteoarthritis (OA). The objectives of this exploratory project were: (i) to characterize worsening criteria in knee and hip OA using psychometric methods; (ii) to estimate their sensitivity and specificity; and (iii) to validate and compare these criteria with worsening criteria previously described in the literature. METHOD: An Expert Group reached consensus on 10 sets of worsening criteria to be tested in observational data sets of patients with knee or hip OA who received multimodal conservative treatment...
February 7, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28271586/single-base-substitutions-in-the-chm-promoter-as-a-cause-of-choroideremia
#6
Alina Radziwon, Gavin Arno, Dianna Wheaton, Ellen M McDonagh, Emma L Baple, Kaylie Webb-Jones, David Birch, Andrew R Webster, Ian M MacDonald
Although over 150 unique mutations affecting the coding sequence of CHM have been identified in patients with the X-linked chorioretinal disease choroideremia (CHM), no regulatory mutations have been reported, and indeed the promoter has not been defined. Here we describe two independent families affected by CHM bearing a mutation outside the gene's coding region at position c.-98: C>A and C>T, which segregated with the disease. The male proband of family 1 was found to lack CHM mRNA and its gene product Rab escort protein 1 (REP-1), while whole genome sequencing of an affected male in family 2 excluded the involvement of any other known retinal genes...
March 8, 2017: Human Mutation
https://www.readbyqxmd.com/read/28263889/proteomic-analysis-of-chondromodulin-i-induced-differentiation-of-mesenchymal-stem-cells-into-chondrocytes
#7
Shuang-Chun Xing, Lian-Xin Du, Wei Zhou, Yu-Qiang Hu, Ya Feng, Hong-Feng Liang, Lin Sang, Min Qi, Li-Jie Zhai, Zhi-Qiang Wang
To identify novel proteins that might help clarify the molecular mechanisms underlying chondromodulin-I (ChM-I) induction of mesenchymal stem cells (MSCs) differentiate into chondrocytes. MSCs are triggered to differentiate into chondrocytes, which are recognized as important factors in cartilage tissue engineering. ChM-I is a glycoprotein that stimulates the growth of chondrocytes and inhibits angiogenesis in vitro. In this study, the proteomic approach was used to evaluate protein changes between undifferentiated MSCs and ChM-I-transfected MSCs...
March 2, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28255333/impact-of-data-model-and-point-density-on-aboveground-forest-biomass-estimation-from-airborne-lidar
#8
Mariano Garcia, Sassan Saatchi, Antonio Ferraz, Carlos Alberto Silva, Susan Ustin, Alexander Koltunov, Heiko Balzter
BACKGROUND: Accurate estimation of aboveground forest biomass (AGB) and its dynamics is of paramount importance in understanding the role of forest in the carbon cycle and the effective implementation of climate change mitigation policies. LiDAR is currently the most accurate technology for AGB estimation. LiDAR metrics can be derived from the 3D point cloud (echo-based) or from the canopy height model (CHM). Different sensors and survey configurations can affect the metrics derived from the LiDAR data...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28254297/a-novel-chitosan-hydrogel-membrane-by-an-improved-electrophoretic-deposition-and-its-characteristics-in-vitro-and-in-vivo
#9
Wen-Wen Li, Hai-Yan Wang, Yu-Qing Zhang
Here, we report a novel chitosan hydrogel membrane (CHM) created by an improved electrophoretic deposition. Unlike a traditional CHM by electrophoretic deposition, the CHM was formed on a nanoporous film as a barrier using a homemade device at a high DC voltage (60 VDC). The CHM maximum recovery of 81.7% could be achieved after 1h of electrophoretic deposition. The transparent CHM with an elongation of 42.46% and swelling index of 538.86% was a mixture of type I and type II crystal structures. SEM revealed that the CHM had an irregular net structure...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28252344/autophagy-inducing-natural-compounds-a-treasure-resource-for-developing-therapeutics-against-tissue-fibrosis
#10
REVIEW
Xiao-Xi Lv, Shan-Shan Liu, Zhuo-Wei Hu
Tissue fibrosis is a common pathologic change of many chronic diseases, which is characterized by extracellular matrix accumulation in tissues and dysfunction of the injured organs. Despite there recently gain mechanistic insight into the pathogenesis of tissue fibrosis, therapeutics for tissue fibrosis and thus many chronic diseases remain a significant clinical unmet need. Recent progressions indicate that autophagy, a conserved lysosomal degradation process in eukaryotic cells, not only plays an important regulatory role in maintaining cellular and tissue homeostasis, but also contributes to the development and progression of tissue fibrosis in a diversity of organs...
February 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28249848/systematic-review-of-the-methodological-quality-of-controlled-trials-evaluating-chinese-herbal-medicine-in-patients-with-rheumatoid-arthritis
#11
Xin Pan, Maria A Lopez-Olivo, Juhee Song, Gregory Pratt, Maria E Suarez-Almazor
OBJECTIVES: We appraised the methodological and reporting quality of randomised controlled clinical trials (RCTs) evaluating the efficacy and safety of Chinese herbal medicine (CHM) in patients with rheumatoid arthritis (RA). DESIGN: For this systematic review, electronic databases were searched from inception until June 2015. The search was limited to humans and non-case report studies, but was not limited by language, year of publication or type of publication...
March 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28230863/oncogenic-role-of-rab-escort-protein-1-through-egfr-and-stat3-pathway
#12
Un-Jung Yun, Jee Young Sung, Seog-Yun Park, Sang-Kyu Ye, Jaegal Shim, Jae-Seon Lee, Masahiko Hibi, Young-Ki Bae, Yong-Nyun Kim
Rab escort protein-1 (REP1) is linked to choroideremia (CHM), an X-linked degenerative disorder caused by mutations of the gene encoding REP1 (CHM). REP1 mutant zebrafish showed excessive cell death throughout the body, including the eyes, indicating that REP1 is critical for cell survival, a hallmark of cancer. In the present study, we found that REP1 is overexpressed in human tumor tissues from cervical, lung, and colorectal cancer patients, whereas it is expressed at relatively low levels in the normal tissue counterparts...
February 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28219357/prescription-frequency-and-patterns-of-chinese-herbal-medicine-for-liver-cancer-patients-in-taiwan-a-cross-sectional-analysis-of-the-national-health-insurance-research-database
#13
Chin-Tsung Ting, Chian-Jue Kuo, Hsiao-Yun Hu, Ya-Ling Lee, Tung-Hu Tsai
BACKGROUND: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Chinese herbal medicine (CHM) is frequently provided to HCC patients. The aim of this study was to understand the prescription frequency and patterns of CHM for HCC patients by analyzing the claims data from the National Health Insurance (NHI) in Taiwan. METHODS: We identified 73918 newly diagnosed HCC subjects from the database of Registry for Catastrophic Illness during 2002 to 2009 and to analyze the frequency and pattern of corresponding CHM prescriptions for HCC patients...
February 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28213110/effect-of-chinese-herbal-medicine-on-stroke-patients-with-type-2-diabetes
#14
Fuu-Jen Tsai, Tsung-Jung Ho, Chi-Fung Cheng, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Cheng-Wen Lin, Jaung-Geng Lin, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and stroke by supplementing Qi and activating blood circulation. AIM OF THE STUDY: This study aimed to investigate the frequencies and patterns of CHM treatment for stroke patients with T2D and the outcomes of long-term use in Taiwan...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28212580/network-pharmacology-based-and-clinically-relevant-prediction-of-the-active-ingredients-and-potential-targets-of-chinese-herbs-in-metastatic-breast-cancer-patients
#15
Yu Mao, Jian Hao, Zi-Qi Jin, Yang-Yang Niu, Xue Yang, Dan Liu, Rui Cao, Xiong-Zhi Wu
Chinese Herbal Medicine (CHM) plays a significant role in breast cancer treatment. We conduct the study to ascertain the relative molecular targets of effective Chinese herbs in treating stage IV breast cancer.Survival benefit of CHM was verified by Kaplan-Meier method and Cox regression analysis. A bivariate correlation analysis was used to find and establish the effect of herbs in complex CHM formulas. A network pharmacological approach was adopted to explore the potential mechanisms of CHM.Patients in the CHM group had a median survival time of 55 months, which was longer than the 23 months of patients in the non-CHM group...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28211792/one-pot-synthesis-of-in-situ-carbon-coated-fe3o4-as-a-long-life-lithium-ion-battery-anode
#16
Min Liu, Hongyun Jin, Evan Uchaker, Zhiqiang Xie, Ying Wang, Guozhong Cao, Shuen Hou, Jiangyu Li
Fe3O4 has been regarded as a promising anode material for lithium-ion batteries (LIBs) due to its high theoretical capacity, low cost, and environmental friendliness. In this work, we present a one-pot reducing-composite-hydroxide-mediated (R-CHM) method to synthesize in situ carbon-coated Fe3O4 (Fe3O4@C) at 280 °C using Fe(NO3)3 · 9H2O and PEG800 as raw materials and NaOH/KOH as the medium. The as-prepared Fe3O4 octahedron has an average size of 100 nm in diameter, covered by a carbon layer with a thickness of 3 nm, as revealed by FESEM and HRTEM images...
April 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28163114/complementary-chinese-herbal-medicine-therapy-improves-survival-of-patients-with-gastric-cancer-in-taiwan-a-nationwide-retrospective-matched-cohort-study
#17
Kuo-Feng Hung, Ching-Ping Hsu, Jen-Huai Chiang, Hung-Jen Lin, Yi-Ting Kuo, Mao-Feng Sun, Hung-Rong Yen
ETHNOPHARMACOLOGICAL RELEVANCE: Many patients with gastric cancer seek traditional medicine consultations in Asian countries. This study aimed to investigate the prescription of Chinese herbal medicine (CHM) and its benefits for the patients with gastric cancer in Taiwan. METHODS: From the Registry for Catastrophic Illness Patients Database, we included all patients with gastric cancer whose age at diagnosis was ≥ 18 from 1997-2010 in Taiwan. We used 1:1 frequency matching by age, sex, Charlson comorbidity score, treatment and index year to compare the CHM users and non-CHM users...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28159846/standardised-versus-individualised-multiherb-chinese-herbal-medicine-for-oligomenorrhoea-and-amenorrhoea-in-polycystic-ovary-syndrome-a-randomised-feasibility-and-pilot-study-in-the-uk
#18
Lily Lai, Andrew Flower, Philip Prescott, Trevor Wing, Michael Moore, George Lewith
OBJECTIVES: To explore feasibility of a randomised study using standardised or individualised multiherb Chinese herbal medicine (CHM) for oligomenorrhoea and amenorrhoea in women with polycystic ovary syndrome (PCOS), to pilot study methods and to obtain clinical data to support sample size calculations. DESIGN: Prospective, pragmatic, randomised feasibility and pilot study with participant and practitioner blinding. SETTING: 2 private herbal practices in the UK...
February 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28153251/selective-and-sensitive-determination-of-as-iii-and-tas-in-chinese-herbal-medicine-samples-using-l-cysteine-modified-carbon-paste-electrode-based-electrolytic-hydride-generation-and-afs-analysis
#19
Xiao-Ping Lu, Xin-An Yang, Lin Liu, Hui-Hui Hu, Wang-Bing Zhang
A novel non-chromatographic speciation technique for ultra-trace arsenite [As(III)] and total arsenic (tAs) in Chinese herbal medicine (CHM) is developed and validated by electrolytic hydride generation (EHG) coupled with atomic fluorescence spectrometry (AFS). The studies show that As(III) can be converted efficiently to AsH3 on an L-cysteine modified carbon paste electrode (CMCPE), which has never been reported before. Significantly, other arsenic species such as arsenate [As(V)], monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) do not form any or only less volatile hydrides at low applied current mode (<1...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28122837/associations-between-prescribed-chinese-herbal-medicine-and-risk-of-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-b-a-nationwide-population-based-cohort-study
#20
Tzung-Yi Tsai, Hanoch Livneh, Tsung-Hsing Hung, I-Hsin Lin, Ming-Chi Lu, Chia-Chou Yeh
OBJECTIVE: Patients with chronic hepatitis B (CHB) are reported to exhibit higher risk of subsequent hepatocellular carcinoma (HCC). However, it remains unclear if Chinese herbal medicine (CHM), an important category of traditional Chinese medicine (TCM), may lower HCC risk in this population. So this study aimed to investigate the effects of CHM on HCC risk among patients with CHB. METHODS: This cohort study used the Taiwanese National Health Insurance Research Database to identify 21 020 newly diagnosed patients with CHB from 1998 to 2007...
January 25, 2017: BMJ Open
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