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https://www.readbyqxmd.com/read/29451409/temporal-trends-in-incidence-and-outcome-of-hydatidiform-mole-a-retrospective-cohort-study
#1
Urika Joneborg, Yasin Folkvaljon, Nikos Papadogiannakis, Mats Lambe, Lena Marions
BACKGROUND: Reported incidence rates of hydatidiform mole (HM) show wide geographic and temporal variations, making reliable international comparisons difficult. The aim of the current study was to examine temporal trends in the incidence of HM and post-molar gestational trophoblastic neoplasia (GTN) in Stockholm County. MATERIAL AND METHODS: Data of all women with a diagnosis of HM in Stockholm County 1991-2010 was collected. The incidence of HM was assessed both in relation to number of births and viable conceptions (births and pregnancy terminations)...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29442745/-okra-abelmoschus-esculentus-plant-extract-assisted-combustion-synthesis-and-characterization-studies-of-spinel-znal%C3%A2-o%C3%A2-nano-catalysts
#2
P Bhavani, A Manikandan, P Paulraj, A Dinesh, M Durka, S Arul Antony
Spinel ZnAl2O4 nano-catalysts were synthesized by a simple, economical and eco-friendly microwave irradiation (MIM) and conventional heating methods (CHM), using metal nitrates and Okra (Abelmoschus esculentus) plant extract, which play a dual role of both oxidizing and reducing nature. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) and selected area electron diffraction (SAED) pattern results were confirmed that the samples have a single-phase cubic spinel structure with high crystalline nature of ZnAl2O4...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439346/chinese-herbal-medicine-for-vascular-dementia-a-systematic-review-and-meta-analysis-of-high-quality-randomized-controlled-trials
#3
Qing-Qing Xu, Chun-Shuo Shan, Yong Wang, Yi-Hua Shi, Qi-Hao Zhang, Guo-Qing Zheng
BACKGROUND: Vascular dementia (VaD) is the second common form of dementia and Chinese herbal medicine (CHM) has been used for aging-related disorders for thousands of years. However, there is still a lack of scientific evidence using CHM for VaD. OBJECTIVE: To conduct a systematic review to assess the current evidence available for the effectiveness and safety of CHM for VaD. METHODS: Six databases were searched for high-quality randomized-controlled clinical trials that met the requirements of at least 4 of the 7 domains of the Cochrane risk of bias tool from their inception to February 2017...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29436108/a-fetus-coexisting-with-a-complete-hydatidiform-mole-with-trisomy-9-of-maternal-origin
#4
Anita Sik Yau Kan, Elizabeth Tak Kwong Lau, Chun Hong So, Wan Pang Chan, Wing Cheuk Wong, Kam Cheong Lee, Mark D Pertile, Mary Hoi Yin Tang
A complete hydatidiform mole (CHM) coexisting with a viable fetus is a rare finding in pregnancies. Accurate diagnosis often relies on ultrasonographic, histopathological and molecular techniques in the definite diagnosis. To the best of our knowledge, a liveborn fetus coexisting with CHM with trisomy 9 has not been described. The use of molecular genotyping and immunohistochemical laboratory investigations enabled the CHM to be fully characterized. Postzygotic diploidization of a triploid conception arising from dispermy is the proposed mechanism of its formation...
February 13, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29414605/use-of-induced-pluripotent-stem-cell-models-to-probe-the-pathogenesis-of-choroideremia-and-to-develop-a-potential-treatment
#5
Thu T Duong, Vidyullatha Vasireddy, Pavitra Ramachandran, Pamela S Herrera, Lanfranco Leo, Carrie Merkel, Jean Bennett, Jason A Mills
Choroideremia (CHM) is a rare monogenic, X-linked recessive inherited retinal degeneration resulting from mutations in the Rab Escort Protein-1 (REP1) encoding CHM gene. The primary retinal cell type leading to CHM is unknown. In this study, we explored the utility of induced pluripotent stem cell-derived models of retinal pigmented epithelium (iPSC-RPE) to study disease pathogenesis and a potential gene-based intervention in four different genetically distinct forms of CHM. A number of abnormal cell biologic, biochemical, and physiologic functions were identified in the CHM mutant cells...
January 27, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29405964/new-insights-in-the-pathophysiology-of-complete-hydatidiform-mole
#6
Eric Jauniaux, Maria Memtsa, Jemma Johns, Jackie A Ross, Davor Jurkovic
OBJECTIVE: The majority of complete hydatidiform moles (CHM) are detected on ultrasound examination by the end of the first trimester when they present as multiple sonolucent cysts. To better understand the pathophysiology of this unique placental pathology and improve its prenatal diagnosis and management we have reviewed the ultrasound features of CHM before the appearance of cystic changes. STUDY DESIGN: We searched our database to identify all women diagnosed with a complete hydatidiform mole confirmed by histopathology who had an ultrasound examination before 9 weeks' gestation...
February 2018: Placenta
https://www.readbyqxmd.com/read/29390351/chinese-herbal-medicine-for-patients-with-atrial-fibrillation-protocol-for-a-systematic-review-and-meta-analysis
#7
Xiaoli Cai, Yuanping Wang, Ziqing Li, Yu Zhang, Dawei Wang, Xia Yan
BACKGROUND: Atrial fibrillation (AF) is the most clinically common cardiac arrhythmia. Chinese herbal medicine (CHM) has been widely applied in the treatment of AF, However, to our knowledge, there has been no systematic review and meta-analysis of randomized controlled trails (RCTs) regarding the effectiveness of this treatment. Therefore, we provide a protocol to evaluate the effectiveness and safety of CHM for AF. METHODS: The databases reviewed to collect RCTs related to CHM treatment for AF will be as follows: 3 English literature databases, which are PubMed, Embase, and Cochrane Library, and 3 Chinese literature databases, which are CBM, CNKI, and Wanfang...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377744/misdiagnosis-of-x-linked-retinitis-pigmentosa-in-a-choroideremia-patient-with-heavily-pigmented-fundi
#8
A Nanda, A P Salvetti, C Martinez-Fernandez de la Camara, R E MacLaren
Inherited retinal diseases are thought to be the leading cause of sight loss in the working age population. Mutations found in the RPGR and CHM genes cause retinitis pigmentosa (RP) and choroideremia, respectively. In the first instance, an X-linked family history of visual field loss commonly raises the suspicion of one of these two genes. In choroideremia, the classic description of a white fundal reflex secondary to the widespread chorioretinal degeneration was made over a hundred years ago in Caucasians...
January 29, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29375653/seeing-the-unseen-of-chinese-herbal-medicine-processing-paozhi-advances-in-new-perspectives
#9
REVIEW
Xu Wu, Shengpeng Wang, Junrong Lu, Yong Jing, Mingxing Li, Jiliang Cao, Baolin Bian, Changjiang Hu
Processing (Paozhi) represents a unique Chinese pharmaceutic technique to facilitate the use of Chinese herbal medicines (CHMs) for a specific clinical need in the guidance of Traditional Chinese Medicine (TCM) theory. Traditionally, most CHMs require a proper processing to meet the needs of specific clinical syndromes before being prescribed by TCM practitioners. During processing, significant changes in chemical profiles occur, which inevitably influence the associated pharmacological properties of a CHM...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29367697/identification-of-microrna-signature-in-the-progression-of-gestational-trophoblastic-disease
#10
Jiu-Ru Zhao, Wei-Wei Cheng, Ya-Xin Wang, Mei Cai, Wei-Bin Wu, Hui-Juan Zhang
Gestational trophoblastic disease (GTD) encompasses a range of trophoblast-derived disorders. The most common type of GTD is hydatidiform mole (HM). Some of HMs can further develop into malignant gestational trophoblastic neoplasia (GTN). Aberrant expression of microRNA (miRNA) is widely reported to be involved in the initiation and progression of cancers. MiRNA expression profile also has been proved to be the useful signature for diagnosis, staging, prognosis, and response to chemotherapy. Till now, the profile of miRNA in the progression of GTD has not been determined...
January 24, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29367200/novel-mutation-in-the-choroideremia-gene-and-multi-mendelian-phenotypes-in-spanish-families
#11
Marta de Castro-Miró, Raul Tonda, Gemma Marfany, Ricardo P Casaroli-Marano, Roser Gonzàlez-Duarte
AIMS: We aimed to accurately diagnose several retinitis pigmentosa (RP) patients with complex ocular phenotypes by combining massive sequencing genetic diagnosis and powerful clinical imaging techniques. METHODS: Whole-exome sequencing (WES) of selected patients from two RP families was undertaken. The variants identified were validated by Sanger sequencing and cosegregation analysis. Accurate clinical re-evaluation was performed using electrophysiological and visual field records as well as non-invasive imaging techniques, such as swept-source optical coherence tomography and fundus autofluorescence...
January 24, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29366767/concurrent-use-of-chinese-herbal-medicine-among-hormone-users-and-its-association-with-ischemic-stroke-risk-a-population-based-study
#12
Shu-Hui Wen, Wei-Chuan Chang, Mun-Kun Hong, Hsien-Chang Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Previous studies had indicated that hormone therapy (HT) may increase the risk of ischemic stroke (IS) in menopausal women. However, little is known about the benefits and risks of use of Chinese herbal medicine (CHM) in conditions related to hormone use. The aim of this study is to explore the risk of IS in menopausal women treated with HT and CHM. MATERIALS AND METHODS: A total of 32,441 menopausal women without surgical menopause aged 40- 65 years were selected from 2003 to 2010 using the 2-million random samples of the National Health Insurance Research Database in Taiwan...
January 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29321719/cancer-chemoprevention-and-therapy-using-chinese-herbal-medicine
#13
REVIEW
Lijing Jiao, Ling Bi, Yan Lu, Qin Wang, Yabin Gong, Jun Shi, Ling Xu
Traditional Chinese medicine (TCM) plays an indispensable role in cancer prevention and treatment. Chinese herbal medicine (CHM) is a key component of TCM and has been practiced for thousands of years. A number of naturally occurring products from Chinese herbs extracts exhibit strong inhibitory properties against carcinogenesis, including CHM single-herb extracts, CHM-derived active components, and CHM formulas (the polyherbal combinations), which regulate JAK/STAT, MAPK, and NF-ҡB pathways. The present review aims to report the cancer-preventive effect of CHM with evidence from cell-line, animal, epidemiological, and clinical experiments...
2018: Biological Procedures Online
https://www.readbyqxmd.com/read/29296092/evaluation-of-amplification-refractory-mutation-system-arms-technique-for-quick-and-accurate-prenatal-gene-diagnosis-of-chm-variant-in-choroideremia
#14
Lisha Yang, Iqra Ijaz, Jingliang Cheng, Chunli Wei, Xiaojun Tan, Md Asaduzzaman Khan, Xiaodong Fu, Junjiang Fu
Choroideremia is a rare X-linked recessive inherited disorder that causes chorioretinal dystrophy leading to visual impairment in its early stages which finally causes total blindness in the affected person. It is caused due to mutations in the CHM gene. In this study, we have recruited a pedigree with choroideremia and detected a nonsense variant (c.C799T:p.R267X) in CHM of the proband (I:1). Different primer sets for amplification refractory mutation system (ARMS) were designed and PCR conditions were optimized...
2018: Application of Clinical Genetics
https://www.readbyqxmd.com/read/29291006/the-application-of-precis-2-ratings-in-randomized-controlled-trials-of-chinese-herbal-medicine
#15
Liming Lu, Li Zhou, Jing Dong, Yu Xiang, Zehuai Wen
This study tests the feasibility of applying the pragmatic-explanatory continuum indicator summary (version "PRECIS-2") tool to randomized controlled trials of Chinese herbal medicine. A search was conducted to identify potentially eligible randomized controlled trials. Using the PRECIS-2 tool, assessment of trials was performed independently by 2 evaluators using a scale of 1-5 for each criterion (1 = maximal efficacy, 5 = maximal effectiveness). A total of 7,166 reports were retrieved from databases and 159 were included in the full text...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29235284/-recent-research-progress-in-immunomodulatory-effects-of-chinese-herbal-medicine-on-asthma-treatment
#16
REVIEW
Fang-Fang Zhou, Zhao-Xia Xu, Aipire Adila, Jin-Yao Li
Asthma is a kind of chronic respiratory inflammation, commonly with breathlessness, chest tightness, coughing, recurrent episodes of wheezing and airflow obstruction, severely affecting human health. A variety of immunocytes are involved in this chronic disease. Chinese herbal medicine(CHM) has a long history in the treatment of asthma. A large number of studies have shown that CHM could ameliorate asthma symptoms through regulating cellular immune responses. This paper reviewed the studies of CHM on the regulation of immunocytes and their mechanisms in recent years, including the count of inflammatory cells, maturation of dendritic cells, balance of helper T cell subtypes, induction of regulatory T cells and intracellular signaling pathways...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29234362/chinese-herbal-medicine-as-an-adjunctive-therapy-ameliorated-the-incidence-of-chronic-hepatitis-in-patients-with-breast-cancer-a-nationwide-population-based-cohort-study
#17
Kuo-Chin Huang, Hung-Rong Yen, Jen-Huai Chiang, Yuan-Chih Su, Mao-Feng Sun, Hen-Hong Chang, Sheng-Teng Huang
We conducted a National Health Insurance Research Database-based Taiwanese nationwide population-based cohort study to evaluate whether Chinese herbal medicine (CHM) treatment decreased the incidence of chronic hepatitis in breast cancer patients receiving chemotherapy and/or radiotherapy. A total of 81171 patients were diagnosed with breast cancer within the defined study period. After randomly equal matching, data from 13856 patients were analyzed. Hazard ratios of incidence rate of chronic hepatitis were used to determine the influence and therapeutic potential of CHM in patients with breast cancer...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29229282/what-is-the-optimal-duration-of-human-chorionic-gonadotrophin-surveillance-following-evacuation-of-a-molar-pregnancy-a-retrospective-analysis-on-over-20-000-consecutive-patients
#18
Christopher Coyle, Dee Short, Lauren Jackson, Neil J Sebire, Baljeet Kaur, Richard Harvey, Philip M Savage, Michael J Seckl
OBJECTIVE: To quantify the risk of developing post-molar gestational trophoblastic neoplasia (pGTN) beyond the first normal human chorionic gonadotrophin (hCG) in women who have had a complete (CHM) or partial molar pregnancy (PHM) and to re-evaluate the current UK Hydatidiform mole hCG surveillance guidelines. METHODS: The Charing Cross Hospital Trophoblast Disease Centre database was screened to identify all registered cases of hydatidiform mole (HM) between 1980 and 2009...
February 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29213243/mechanism-of-chinese-medicine-herbs-effects-on-chronic-heart-failure-based-on-metabolic-profiling
#19
Kuo Gao, Huihui Zhao, Jian Gao, Binyu Wen, Caixia Jia, Zhiyong Wang, Feilong Zhang, Jinping Wang, Hua Xie, Juan Wang, Wei Wang, Jianxin Chen
Chronic heart failure (CHF) is a major public health problem in huge population worldwide. The detailed understanding of CHF mechanism is still limited. Zheng (syndrome) is the criterion of diagnosis and therapeutic in Traditional Chinese Medicine (TCM). Syndrome prediction may be a better approach for understanding of CHF mechanism basis and its treatment. The authors studied disturbed metabolic biomarkers to construct a predicting mode to assess the diagnostic value of different syndrome of CHF and explore the Chinese herbal medicine (CHM) efficacy on CHF patients...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29200714/simultaneous-determination-of-ten-constituents-in-chaiqin-qingning-capsule-by-high-performance-liquid-chromatography-coupled-with-triple-quadrupole-mass-spectrometry
#20
Ting Yu Li, Xiao Kui Huo, Lu Zheng, Chao Wang, Hai Jian Cong, Ting Xiang, Lin Zhang, Bao Jing Zhang, Shan Shan Huang, Bin Wu, Xin Yu Li
Background: Chaiqin Qingning Capsule (CQQNC) was a prescription of Traditional Chinese Medicine with the effects of clearing away heat and removing toxin, harmonizing the exterior and interior, it was widely used in Asian, for example, China and Japan, different batches of the raws materials and different processing time may be the vital factor which raised a challenge to control the quality of the CQQNC. Experimental Methods: In this experiment, a high-performance liquid chromatography-mass spectrometry/MS (HPLC-MS/MS) method was developed to simultaneously determine ten bioactive components for the quality control of CQQNC...
October 2017: Pharmacognosy Magazine
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