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https://www.readbyqxmd.com/read/27889382/rare-and-common-variants-at-16p11-2-are-associated-with-schizophrenia
#1
Hong Chang, Lingyi Li, Ming Li, Xiao Xiao
Recent studies suggest that both common and rare variants are involved in the genetic risk of schizophrenia. Using a Cochran-Mantel-Haenszel (CMH) adjusted meta-analysis in 36,676 schizophrenia patients and 48,331 healthy controls from 24 independent samples, we identify the microduplications at 16p11.2 locus (29.6-30.2Mb, hg19) to be strongly associated with the illness (P value<2.2×10(-16), CHM-adjusted OR=10.79). The frequency of this microduplication is significantly higher in schizophrenia patients (0...
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27857244/a-pioneer-paediatrician-in-new-zealand-geoffrey-bruton-sweet-1-9-1870-17-5-1939-mb-chm-sydney-1893
#2
William J Sugrue, Patricia M Clarkson
Paediatrics as a specialty was slow to emerge in New Zealand where Geoffrey Bruton Sweet was a pioneer full-time paediatrician from 1907 to 1939. Although there had been appointments as paediatric lecturers to the Otago Medical School, the early appointees were not restricted to paediatric practice. Dr Sweet, an Australian graduate, came to New Zealand and made a major contribution to the development of pathology services before embarking on a career devoted to paediatrics. He was a powerful advocate for children, well read and interested in clinical research, and realised the need to communicate with those directly involved in the care of children...
November 18, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27848250/pharmacological-effects-of-active-components-of-chinese-herbal-medicine-in-the-treatment-of-alzheimer-s-disease-a-review
#3
Zhi-Yong Wang, Jian-Gang Liu, Hao Li, Hui-Ming Yang
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM)...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27820636/the-spectrum-of-chm-gene-mutations-in-choroideremia-and-their-relationship-to-clinical-phenotype
#4
Matthew P Simunovic, Jasleen K Jolly, Kanmin Xue, Thomas L Edwards, Markus Groppe, Susan M Downes, Robert E MacLaren
Purpose: We report the underlying genotype and explore possible genotypic-phenotypic correlations in a large cohort of choroideremia patients. Methods: We studied prospectively a cohort of 79 patients diagnosed within a tertiary referral service for patients with retinal dystrophies. Phenotypic evaluation consisted of clinical examination, including visual acuity and residual retinal area by fundus autofluorescence (FAF). Genotype was established by sequencing. We also investigated whether particular genotypes were associated with more severe phenotypes by performing analysis of covariance (ANCOVA), with visual acuity and FAF as the dependent variables and age as the covariant...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27774897/the-role-of-biologically-active-ingredients-from-chinese-herbal-medicines-in-the-regulation-of-autophagy-in-treating-cardiovascular-diseases-and-other-chronic-diseases
#5
Jie Li, Yonghong Gao, Xiaomeng Ren, Yanda Li, Lijun Wu, Xinyu Yang, Jie Wang, Hongcai Shang, Xingjiang Xiong, Yanwei Xing
Autophagy, a highly conserved starvation response mechanism with both defensive and protective effects in eukaryotic cells, is a lysosome-mediated degradation process for non-essential or damaged cellular constituents. It plays an important role in the cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in cardiovascular diseases, cerebrovascular diseases, and neurodegenerative disease, as well as tumours. Thus, modulating autophagy may provide potential therapeutic strategies...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27774110/chinese-herbal-medicine-for-postpartum-depression-a-systematic-review-of-randomized-controlled-trials
#6
Yongle Li, Zijie Chen, Ning Yu, Keyu Yao, Yiwen Che, Yupeng Xi, Shuangqing Zhai
Background. Postpartum depression (PPD) does great harm to women following childbirth. The aim of this study was to conduct a systematic review of the literature to assess the efficacy and safety of CHM for the treatment of PPD. Methods. Published or ongoing registered trials were searched for from the inception of the various databases to December 31, 2015. Data extraction and methodology assessment were conducted independently by two researchers. RevMan 5.3 software was used to analyze the data. Results. Forty-seven registered clinical trials (RCTs) were identified and reviewed...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27753762/clinical-progress-in-inherited-retinal-degenerations-gene-therapy-clinical-trials-and-advances-in-genetic-sequencing
#7
Brian P Hafler
PURPOSE: Inherited retinal dystrophies are a significant cause of vision loss and are characterized by the loss of photoreceptors and the retinal pigment epithelium (RPE). Mutations in approximately 250 genes cause inherited retinal degenerations with a high degree of genetic heterogeneity. New techniques in next-generation sequencing are allowing the comprehensive analysis of all retinal disease genes thus changing the approach to the molecular diagnosis of inherited retinal dystrophies...
October 6, 2016: Retina
https://www.readbyqxmd.com/read/27750291/a-qualitative-and-quantitative-assessment-of-fundus-autofluorescence-patterns-in-patients-with-choroideremia
#8
Jasleen K Jolly, Thomas L Edwards, Jonathan Moules, Markus Groppe, Susan M Downes, Robert E MacLaren
Purpose: We set out to characterize the pattern of fundus autofluorescence (AF) loss in choroideremia (CHM) patients of varying ages and disease severity in order to determine the average rate of progression of this potential disease biomarker. Methods: Fifty consecutive CHM patients (100 eyes) attending outpatient clinics at Oxford Eye Hospital underwent analysis with the Heidelberg OCT Spectralis with autofluorescence capabilities. The area of residual AF was traced using Heidelberg Eye Explorer...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27749547/bioactive-components-of-chinese-herbal-medicine-enhance-endogenous-neurogenesis-in-animal-models-of-ischemic-stroke-a-systematic-analysis
#9
Ji-Huang Li, Zi-Xian Chen, Xiao-Guang Zhang, Yan Li, Wen-Ting Yang, Xia-Wei Zheng, Shuang Chen, Lin Lu, Yong Gu, Guo-Qing Zheng
BACKGROUND: Chinese herbal medicine (CHM) has been used to treat stroke for thousands of years. The objective of the study is to assess the current evidence for bioactive components of CHM as neurogenesis agent in animal models of ischemic stroke. METHODS: We searched PubMed, China National Knowledge Infrastructure, WanFang Database, and VIP Database for Chinese Technical Periodicals published from the inception up to November 2015. The primary measured outcome was one of neurogenesis biomarker, including Bromodeoxyuridine (BrdU), Nestin, doublecortin (DCX), polysialylated form of the neural cell adhesion molecule (PSA-NCAM), neuronal nuclear antigen (NeuN), and glial fibrillary acidic protein (GFAP)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27739455/novel-chm-mutations-identified-in-chinese-families-with-choroideremia
#10
Xue-Bi Cai, Xiu-Feng Huang, Yi Tong, Qin-Kang Lu, Zi-Bing Jin
Choroideremia is a bilateral and progressive X-linked inherited disease characterized by widespread chorioretinal atrophy with relative sparing of the macular region. It is caused by mutations in the ubiquitously expressed CHM gene, which lead to the absence of the Rab escort protein 1 (REP-1), resulting in prenylation deficiency. Typical fundus appearances for choroideremia were found in 3 probands from three unrelated Chinese families in our study. We firstly used the targeted exome sequencing (TES) technology to detect mutations in CHM gene...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27731904/chinese-herbal-medicine-for-subfertile-women-with-polycystic-ovarian-syndrome
#11
REVIEW
Kunyan Zhou, Jing Zhang, Liangzhi Xu, Taixiang Wu, Chi Eung Danforn Lim
BACKGROUND: Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrinology abnormalities, and affects 5% to 10% of women of reproductive age. Western medicines, such as oral contraceptives, insulin sensitizers and laparoscopic ovarian drilling (LOD), have been used to treat PCOS. Recently, many studies have been published that consider Chinese herbal medicine (CHM) as an alternative treatment for women with PCOS. OBJECTIVES: To assess the efficacy and safety of CHM for subfertile women with PCOS...
October 12, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27716354/accuracy-of-p57-kip2-compared-with-genotyping-for-the-diagnosis-of-complete-hydatidiform-mole-protocol-for-a-systematic-review-and-meta-analysis
#12
Jose Mauro Madi, Antonio Rodrigues Braga, Machline Paim Paganella, Isnard Elman Litvin, Eliana Márcia Da Ros Wendland
BACKGROUND: Distinguishing hydatidiform moles (HMs) from non-molar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of gestational trophoblastic neoplasia. However, diagnosis based solely on morphology has poor interobserver reproducibility. Recent studies have demonstrated that the use of p57(KIP2) immunostaining improves diagnostic accuracy for CHM. METHODS: We will conduct a systematic review of prospective and retrospective studies to evaluate the accuracy of p57(KIP2) immunostaining compared with molecular genotyping for the diagnosis of CHM...
October 4, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27698555/efficacy-and-safety-of-chinese-herbal-medicine-for-chronic-prostatitis-associated-with-damp-heat-and-blood-stasis-syndromes-a-meta-analysis-and-literature-review
#13
Zhiqiang Wang, Lei Yuan, Yongchuan Wang, Baizhi Yang, Xiaohong Dong, Zhaowang Gao
OBJECTIVE: The aim of this meta-analysis and systematic review is to evaluate the safety and efficacy of Chinese herbal medicine (CHM) for chronic prostatitis (CP) associated with damp-heat and blood-stasis syndromes. METHODS: An electronic search of 13 databases up to May 2016 was screened to identify randomized controlled trials comparing the safety and efficacy of CHM for the treatment of CP associated with damp-heat and blood-stasis syndromes. Studies reporting on effective rates, adverse events, National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) scores, and symptom index of Chinese medicine for chronic prostatitis (SI-CM) scores as outcomes were included in the analysis...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27685995/genome-analysis-of-osteosarcoma-progression-samples-identifies-fgfr1-overexpression-as-a-potential-treatment-target-and-chm-as-a-candidate-tumor-suppressor-gene
#14
Tale Barøy, Chandra S R Chilamakuri, Susanne Lorenz, Jinchang Sun, Øyvind S Bruland, Ola Myklebost, Leonardo A Meza-Zepeda
Osteosarcoma (OS) is the most common primary malignant tumor of bone, showing complex chromosomal rearrangements but with few known consistent changes. Deeper biological understanding is crucial to find new therapies to improve patient survival. We have sequenced the whole exome of two primary tumors (before and after chemotherapy), one metastatic tumor and a matched normal sample from two OS patients, to identify mutations involved in cancer biology. The metastatic samples were also RNA sequenced. By RNA sequencing we identified dysregulated expression levels of drug resistance- and apoptosis-related genes...
2016: PloS One
https://www.readbyqxmd.com/read/27651817/systematic-review-on-chinese-herbal-medicine-induced-liver-injury
#15
REVIEW
Peng Zhang, Yongan Ye, Xianzhao Yang, Yuntao Jiao
Background. In recent years, with the popularity of CHM, its hepatotoxicity has also been increasingly noticed. However, there are still veils on causative herbs and clinical characteristics. Aim. To systematically review data on CHM induced liver injury with particular focus on causative herbs and clinical characteristics. Methods. Using terms related to CHM and liver injury, PubMed and three Chinese electronic databases were searched, which was limited to the past 5 years. Publications meeting our eligibility criteria were included and further analyzed...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27647859/smoking-is-associated-with-higher-disease-related-costs-and-lower-health-related-quality-of-life-in-inflammatory-bowel-disease
#16
M Severs, M-J J Mangen, M E van der Valk, H H Fidder, G Dijkstra, M van der Have, A A van Bodegraven, D J de Jong, C J van der Woude, M J L Romberg-Camps, C H M Clemens, J M Jansen, P C van de Meeberg, N Mahmmod, C Y Ponsioen, J R Vermeijden, A E van der Meulen-de Jong, M Pierik, P D Siersema, B Oldenburg
BACKGROUND AND AIMS: Smoking affects the course of inflammatory bowel disease [IBD]. We aimed to study the impact of smoking on IBD-specific costs and health-related quality-of-life [HrQoL] among adults with Crohn's disease [CD] and ulcerative colitis [UC]. METHODS: A large cohort of IBD patients was prospectively followed during 1 year using 3-monthly questionnaires on smoking status, health resources, disease activity and HrQoL. Costs were calculated by multiplying used resources with corresponding unit prices...
September 19, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27641605/post-hematopoietic-stem-cell-transplantation-in-patients-with-hematologic-disorders-chinese-herbal-medicine-for-an-unmet-need
#17
REVIEW
Tom Fleischer, Tung-Ti Chang, Hung-Rong Yen
While much progress has been made in the field of hematopoietic stem cell transplantation (HSCT), headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine (CHM) for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention...
September 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27599108/phenotyping-choroideremia-and-its-carrier-state-with-multimodal-imaging-techniques
#18
Kevin K Ma, James Lin, Katherine Boudreault, Royce W S Chen, Stephen H Tsang
PURPOSE: To describe findings in a patient with choroideremia (CHM) and his mother, an obligate CHM carrier. METHODS: Case report. RESULTS: A 25-year-old man with nyctalopia and poor peripheral vision since childhood, as well as a family history consistent with an X-linked retinal disorder was diagnosed with CHM. His asymptomatic 50-year-old mother, an obligate carrier, was also examined. Fundus examination of the affected man showed significant atrophy of the choroid and retinal pigment epithelium, whereas the carrier woman showed patchy pigmentary mottling...
September 2, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27583849/network-pharmacology-dissection-of-multiscale-mechanisms-of-herbal-medicines-in-stage-iv-gastric-adenocarcinoma-treatment
#19
Li Gao, Jian Hao, Yang-Yang Niu, Miao Tian, Xue Yang, Cui-Hong Zhu, Xiu-Li Ding, Xiao-Hui Liu, Hao-Ran Zhang, Chang Liu, Xue-Mei Qin, Xiong-Zhi Wu
Increasing evidence has shown that Chinese Herbal Medicine (CHM) has efficient therapeutic effects for advanced gastric adenocarcinoma, while the therapeutic mechanisms underlying this treatment remain unclear.In this study, the Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of CHM treatment, and correlation analysis was applied to identify the most effective components in the formulas. A network pharmacological approach was developed to decipher the potential therapeutic mechanisms of CHM...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27538116/chinese-herbal-medicine-for-atopic-eczema-an-overview-of-clinical-evidence
#20
Sherman X Gu, Anthony L Zhang, Meaghan E Coyle, Dacan Chen, Charlie C Xue
Atopic eczema (AE), or atopic dermatitis, is a common inflammatory skin disease. As conventional medicines for moderate and severe AE patients have been reported to be associated with unwanted side effects, many patients with AE have sought other therapies. Chinese herbal medicine (CHM) is one of the most commonly used complementary therapies with a long history of being applied for the treatment of AE. Clinical evidence for CHM for AE in systematic reviews and randomised controlled trials (RCTs) published from 2013 to 2016 was reviewed...
August 18, 2016: Journal of Dermatological Treatment
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