Mona Khan, Marnick Clijsters, Sumin Choi, Wout Backaert, Michiel Claerhout, Floor Couvreur, Laure Van Breda, Florence Bourgeois, Kato Speleman, Sam Klein, Johan Van Laethem, Gill Verstappen, Ayse Sumeyra Dereli, Seung-Jun Yoo, Hai Zhou, Thuc Nguyen Dan Do, Dirk Jochmans, Lies Laenen, Yves Debaveye, Paul De Munter, Jan Gunst, Mark Jorissen, Katrien Lagrou, Philippe Meersseman, Johan Neyts, Dietmar Rudolf Thal, Vedat Topsakal, Christophe Vandenbriele, Joost Wauters, Peter Mombaerts, Laura Van Gerven
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct and short route from the nose into the brain? We reasoned that the neurotropic or neuroinvasive capacity of the virus, if it exists, should be most easily detectable in individuals who died in an acute phase of the infection. Here, we applied a postmortem bedside surgical procedure for the rapid procurement of tissue, blood, and cerebrospinal fluid samples from deceased COVID-19 patients infected with the Delta, Omicron BA.1, or Omicron BA...
December 7, 2022: Neuron