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A S Gauthier, R Billon-Grand, A Rivet, M Chatain, M Saleh, B Delbosc
No abstract text is available yet for this article.
January 3, 2017: Journal Français D'ophtalmologie
Alysse Rivet, Anne-Sophie Gauthier, Marion Chatain, Romain Billon-Grand, Laurent Thines, Bernard Delbosc
A 53-year-old woman was found to have a left inferior homonymous quadrantanopia. Brain MRI disclosed a giant Virchow-Robin space compressing the right optic tract. After fenestration of this cystic lesion, most of the visual field loss resolved. Giant Virchow-Robin spaces may cause homonymous field defects which, with appropriate management, may improve.
March 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
T C Cardoso, H L Ferreira, L H Okamura, T P Giroto, B R S M Oliveira, C U F Fabri, R Gameiro, E F Flores
The present study reports an investigation on the phenotype of inflammatory and immune cells, cytokine and viral gene expression in the brains of cattle naturally infected with bovine herpesvirus 5 (BHV5). Brain sections of 38 affected animals were analysed for the nature and extent of perivascular cuffs in the Virchow-Robin space and parenchyma. Histopathological changes were severe in the olfactory bulbs (Obs), hippocampus, piriform, frontal, temporal and parietal cortices/lobes and were characterized by inflammatory infiltrates in Virchow-Robin spaces...
December 2016: Veterinary Journal
Iype Cherian, Margarita Beltran, Ekkehard M Kasper, Binod Bhattarai, Sunil Munokami, Giovanni Grasso
BACKGROUND: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. METHODS: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI)...
2016: Surgical Neurology International
Ling-Yun Guo, Lin-Lin Liu, Yue Liu, Tian-Ming Chen, Shao-Ying Li, Yong-Hong Yang, Gang Liu
BACKGROUND: Data regarding HIV-seronegative pediatric patients with cryptococcal meningitis (CM) have been very limited. METHODS: We retrospectively reviewed non-HIV-infected in patients with CM from January 2002 through December 2013 in Beijing Children's Hospital. Records of the all patients were obtained and compared. RESULTS: The 34 children had a median age of 5.6 years. Most of the patients were male (67.6 %). Only 23.5 % of the cases had identifiable underlying diseases...
November 4, 2016: BMC Infectious Diseases
Stefan Mogk, Christian M Boßelmann, Celestin N Mudogo, Jasmin Stein, Hartwig Wolburg, Michael Duszenko
African trypanosomes induce sleeping sickness. The parasites are transmitted during the blood meal of a tsetse fly and appear primarily in blood and lymph vessels, before they enter the central nervous system. During the latter stage, trypanosomes induce a deregulation of sleep-wake cycles and some additional neurological disorders. Historically, it was assumed that trypanosomes cross the blood-brain barrier and settle somewhere between the brain cells. The brain, however, is a strictly controlled and immune-privileged area that is completely surrounded by a dense barrier that covers the blood vessels: this is the blood-brain barrier...
October 14, 2016: Biological Reviews of the Cambridge Philosophical Society
Yuqiao Xu, Lijuan Ye, Yingmei Wang, Wanling Ma, Qing Li
No abstract text is available yet for this article.
November 2016: Clinical Neuropathology
Jacob Joseph Moar, Lawrence Hill, Michael Stewart
Although cobra envenomation continues to pose a threat to life and therefore constitutes a major cause of death in Africa, India, and Sri Lanka, the forensic pathology reports are not always histologically well documented or illustrated. The reports in the literature, although providing graphic evidence of the macroscopic appearances of the bite and its ensuing tissue necrosis, should the victim survive, often do not illustrate the histopathological findings to a sufficient degree. We present an unusual case of fatal envenomation by a rinkhals (Hemachatus haemachatus) in which the victim had been bitten a second time after a previous rinkhals' bite...
December 2016: American Journal of Forensic Medicine and Pathology
Rick I Meijer, Sarah M Gray, Kevin W Aylor, Eugene J Barrett
Insulin affects multiple important central nervous system (CNS) functions including memory and appetite, yet the pathway(s) by which insulin reaches brain interstitial fluid (bISF) has not been clarified. Recent studies demonstrate that to reach bISF, subarachnoid cerebrospinal fluid (CSF) courses through the Virchow-Robin space (VRS) which sheaths penetrating pial vessels down to the capillary level. Whether insulin predominantly enters the VRS and bISF by local transport through the blood-brain barrier, or by being secreted into the CSF by the choroid plexus, is unknown...
November 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Peter Wostyn, Veva De Groot, Debby Van Dam, Kurt Audenaert, Hanspeter Esriel Killer, Peter Paul De Deyn
No abstract text is available yet for this article.
August 2016: Acta Radiologica Open
N Vilor-Tejedor, S Alemany, J Forns, A Cáceres, M Murcia, D Macià, J Pujol, J Sunyer, J R González
OBJECTIVE: ADHD consists of a count of symptoms that often presents heterogeneity due to overdispersion and excess of zeros. Statistical inference is usually based on a dichotomous outcome that is underpowered. The main goal of this study was to determine a suited probability distribution to analyze ADHD symptoms in Imaging Genetic studies. METHOD: We used two independent population samples of children to evaluate the consistency of the standard probability distributions based on count data for describing ADHD symptoms...
August 17, 2016: Journal of Attention Disorders
Naoya Kawahara, Sosuke Ofuji, Sakae Abe, Ai Tanaka, Masami Uematsu, Yoshimi Ogata
Water intoxication is a common disorder in calves and is usually characterized by transient hemoglobinuria. In contrast, the condition is very rare in adult cattle, with few reports on naturally occurring cases. In the present report, four female Japanese Black cattle, aged 16-25 months, showed neurological signs when they drank water following a water outage. Hemoglobinuria was not grossly observed, while severe hyponatremia was revealed by laboratory tests. Autopsy indicated cerebral edema with accumulation of serous fluid in expanded Virchow-Robin spaces...
May 2016: Japanese Journal of Veterinary Research
Erin D Bigler, Tracy J Abildskov, Naomi J Goodrich-Hunsaker, Garrett Black, Zachary P Christensen, Trevor Huff, Dawn-Marie G Wood, John R Hesselink, Elisabeth A Wilde, Jeffrey E Max
Common neuroimaging findings in mild traumatic brain injury (mTBI), including sport-related concussion (SRC), are reviewed based on computed tomography and magnetic resonance imaging (MRI). Common abnormalities radiologically identified on the day of injury, typically a computed tomographic scan, are in the form of contusions, small subarachnoid or intraparenchymal hemorrhages as well as subdural and epidural collections, edema, and skull fractures. Common follow-up neuroimaging findings with MRI include white matter hyperintensities, hypointense signal abnormalities that reflect prior hemorrhage, focal encephalomalacia, presence of atrophy and/or dilated Virchow-Robins perivascular space...
September 2016: Sports Medicine and Arthroscopy Review
P Roman-Pena, L Gonzalez-Gomez, J M Santin-Amo, M Arias, M Gelabert-Gonzalez
No abstract text is available yet for this article.
July 1, 2016: Revista de Neurologia
Hieab H H Adams, Saima Hilal, Petra Schwingenschuh, Katharina Wittfeld, Sven J van der Lee, Charles DeCarli, Meike W Vernooij, Petra Katschnig-Winter, Mohamad Habes, Christopher Chen, Sudha Seshadri, Cornelia M van Duijn, M Kamran Ikram, Hans J Grabe, Reinhold Schmidt, M Arfan Ikram
INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. METHODS: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www...
December 2015: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Yasuhiro Ooi, Chizuko Inui-Yamamoto, Yoshichika Yoshioka, Akitoshi Seiyama, Junji Seki
PURPOSE: 11.7 Tesla MRI was examined to detect Virchow-Robin spaces (VRSs) smaller than 100 μm in the rat brain. The effects of maternal exposure to lipopolysaccharide (LPS) were evaluated on basis of the number of dilated VRSs in the offspring rat brain. METHODS: T2-weighted MRI with an in-plane resolution up to 78 μm (repetition time = 5000 ms, echo time = 35 ms, slice thickness = 250 μm, imaging plane, coronal) was applied to identify VRSs. The dilated VRSs were counted in the rat brain at 5 and 10 weeks of age...
January 10, 2017: Magnetic Resonance in Medical Sciences: MRMS
Alan W J Morris, Matthew MacGregor Sharp, Nazira J Albargothy, Rute Fernandes, Cheryl A Hawkes, Ajay Verma, Roy O Weller, Roxana O Carare
In the absence of conventional lymphatics, drainage of interstitial fluid and solutes from the brain parenchyma to cervical lymph nodes is along basement membranes in the walls of cerebral capillaries and tunica media of arteries. Perivascular pathways are also involved in the entry of CSF into the brain by the convective influx/glymphatic system. The objective of this study is to differentiate the cerebral vascular basement membrane pathways by which fluid passes out of the brain from the pathway by which CSF enters the brain...
May 2016: Acta Neuropathologica
Iype Cherian, Antonio Bernardo, Giovanni Grasso
OBJECTIVE: Traumatic brain injury (TBI) is one of the major challenges in health care, representing the third most frequent cause of death. Current optimal management is based on a progressive, target-driven approach combining both medical and surgical treatment strategies. Here we describe cisternostomy, an emerging surgical treatment for the treatment of TBI. METHODS: Cisternostomy is a novel technique that incorporates knowledge of skull base and microvascular surgery...
May 2016: World Neurosurgery
Lilian Calderón-Garcidueñas, Rafael Reynoso-Robles, Javier Vargas-Martínez, Aline Gómez-Maqueo-Chew, Beatriz Pérez-Guillé, Partha S Mukherjee, Ricardo Torres-Jardón, George Perry, Angélica Gónzalez-Maciel
Millions of urban children are chronically exposed to high concentrations of air pollutants, i.e., fine particulate matter (PM2.5) and ozone, associated with increased risk for Alzheimer's disease. Compared with children living with clear air those in Mexico City (MC) exhibit systemic, brain and intrathecal inflammation, low CSF Aβ42, breakdown of the BBB, attention and short-term memory deficits, prefrontal white matter hyperintensities, damage to epithelial and endothelial barriers, tight junction and neural autoantibodies, and Alzheimer and Parkinson's hallmarks...
April 2016: Environmental Research
Janna H Neltner, Erin L Abner, Gregory A Jicha, Frederick A Schmitt, Ela Patel, Leonard W Poon, Gearing Marla, Robert C Green, Adam Davey, Mary Ann Johnson, S Michal Jazwinski, Sangkyu Kim, Daron Davis, John L Woodard, Richard J Kryscio, Linda J Van Eldik, Peter T Nelson
With an emphasis on evolving concepts in the field, we evaluated neuropathologic data from very old research volunteers whose brain autopsies were performed at the University of Kentucky Alzheimer's Disease Center, incorporating data from the Georgia Centenarian Study (n = 49 cases included), Nun Study (n = 17), and University of Kentucky Alzheimer's Disease Center (n = 11) cohorts. Average age of death was 102.0 (range: 98-107) years overall. Alzheimer's disease pathology was not universal (62% with "moderate" or "frequent" neuritic amyloid plaque densities), whereas frontotemporal lobar degeneration was absent...
January 2016: Neurobiology of Aging
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