Frederik Loewenstein, Sabrina Becker, Josef Kuehling, Hansjörg Schrade, Mirjam Lechner, Robert Ringseis, Klaus Eder, Andreas Moritz, Gerald Reiner
BACKGROUND: Swine inflammation and necrosis syndrome (SINS) can lead to significant clinical alterations at tail, ears, claws and other parts of the body in suckling piglets, weaners and fatteners. Clinical findings are associated with vasculitis, intima proliferation and thrombosis. The syndrome can be found in newborns, indicating a primarily endogenous aetiology. It has been hypothesized that SINS is triggered by gut-derived microbial-associated molecular patterns, causing derangements in liver metabolism and activity of peripheral white blood cells involving inflammation and blood haemostasis...
January 19, 2022: BMC Veterinary Research