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https://www.readbyqxmd.com/read/29233559/tumour-infiltrating-lymphocytes-and-prognosis-in-different-subtypes-of-breast-cancer-a-pooled-analysis-of-3771-patients-treated-with-neoadjuvant-therapy
#1
Carsten Denkert, Gunter von Minckwitz, Silvia Darb-Esfahani, Bianca Lederer, Barbara I Heppner, Karsten E Weber, Jan Budczies, Jens Huober, Frederick Klauschen, Jenny Furlanetto, Wolfgang D Schmitt, Jens-Uwe Blohmer, Thomas Karn, Berit M Pfitzner, Sherko Kümmel, Knut Engels, Andreas Schneeweiss, Arndt Hartmann, Aurelia Noske, Peter A Fasching, Christian Jackisch, Marion van Mackelenbergh, Peter Sinn, Christian Schem, Claus Hanusch, Michael Untch, Sibylle Loibl
BACKGROUND: Tumour-infiltrating lymphocytes (TILs) are predictive for response to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) and HER2-positive breast cancer, but their role in luminal breast cancer and the effect of TILs on prognosis in all subtypes is less clear. Here, we assessed the relevance of TILs for chemotherapy response and prognosis in patients with TNBC, HER2-positive breast cancer, and luminal-HER2-negative breast cancer. METHODS: Patients with primary breast cancer who were treated with neoadjuvant combination chemotherapy were included from six randomised trials done by the German Breast Cancer Group...
December 7, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29223359/in-niemann-pick-c1-mouse-models-glial-only-expression-of-the-normal-gene-extends-survival-much-further-than-do-changes-in-genetic-background-or-treatment-with-hydroxypropyl-beta-cyclodextrin
#2
Craig A Marshall, Dawn E Watkins-Chow, Giampiero Palladino, Gail Deutsch, Keshav Chandran, William J Pavan, Robert P Erickson
The Npc1nmf164 allele of Npc1 provides a mouse model for Niemann-Pick disease type C1 (NPC1), a genetic disease known to have a widely variable phenotype. The transfer of the Npc1nmf164 mutation from the C57BL/6J inbred strain to the BALB/cJ inbred strain increased the mean lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background. The transfer of another Npc1 allele, Npc1nih, to this background also extended survival of the homozygotes indicating that the modifying effect of BALB/cJ is not limited to a single allele of Npc1...
December 6, 2017: Gene
https://www.readbyqxmd.com/read/29217134/reirradiation-with-concurrent-bevacizumab-for-recurrent-high-grade-gliomas-in-adult-patients
#3
A Schernberg, F Dhermain, S Ammari, S N Dumont, J Domont, A Patrikidou, J Pallud, É Dezamis, É Deutsch, G Louvel
PURPOSE: To analyse feasibility, prognostic factors and patterns of recurrence after concurrent reirradiation and bevacizumab for recurrent high-grade gliomas. PATIENTS AND METHODS: Between 2009 and 2015, 35 patients (median 57-year-old; 21 men, 14 women) with WHO grade III (n=11) or grade IV (n=24) gliomas were included in this retrospective and consecutive single-centre study. All patients received bevacizumab (median number of treatments: 12) concomitant with reirradiation (median dose: 45Gy, median number of fractions: 18) for recurrence with median 22 months (range: 5...
December 4, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29216678/-guideline-for-the-diagnosis-and-treatment-of-asthma-guideline-of-the-german-respiratory-society-and-the-german-atemwegsliga-in-cooperation-with-the-paediatric-respiratory-society-and-the-austrian-society-of-pneumology
#4
R Buhl, R Bals, X Baur, D Berdel, C-P Criée, M Gappa, A Gillissen, T Greulich, P Haidl, E Hamelmann, P Kardos, K Kenn, L Klimek, S Korn, M Lommatzsch, H Magnussen, T Nicolai, D Nowak, O Pfaar, K F Rabe, J Riedler, T Ritz, K Schultz, A Schuster, T Spindler, R C Taube, K Taube, C Vogelmeier, A von Leupold, F Wantke, S Weise, J Wildhaber, H Worth, A Zacharasiewicz
The present guideline is a new version and an update of the guideline for the diagnosis and treatment of asthma, which replaces the previous version for german speaking countries from the year 2006. The wealth of new data on the pathophysiology and the phenotypes of asthma, and the expanded spectrum of diagnostic and therapeutic options necessitated a new version and an update. This guideline presents the current, evidence-based recommendations for the diagnosis and treatment of asthma, for children and adolescents as well as for adults with asthma...
December 2017: Pneumologie
https://www.readbyqxmd.com/read/29197019/-quality-indicators-for-pancreatic-surgery-scientific-derivation-and-clinical-relevance
#5
REVIEW
U F Wellner, R Grützmann, T Keck, N Nüssler, H E Witzigmann, H-J Buhr
Quality indicators are by definition indirect measures of quality. The selection for the field of pancreatic surgery was based on the clinical relevance and controllability, scientific evidence and the practicability of data acquisition. In terms of outcome quality, hospital mortality, the composite endpoint MTL30 (mortality-transfer-length of stay), and major complications (Clavien-Dindo classification grades 3b and 4) were chosen as being essential. With respect to structural quality, the presence of interventional radiology with constant availability was considered essential...
December 1, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29191323/transcatheter-aortic-valve-replacement-in%C3%A2-pure-native-aortic-valve-regurgitation
#6
MULTICENTER STUDY
Sung-Han Yoon, Tobias Schmidt, Sabine Bleiziffer, Niklas Schofer, Claudia Fiorina, Antonio J Munoz-Garcia, Ermela Yzeiraj, Ignacio J Amat-Santos, Didier Tchetche, Christian Jung, Buntaro Fujita, Antonio Mangieri, Marcus-Andre Deutsch, Timm Ubben, Florian Deuschl, Shingo Kuwata, Chiara De Biase, Timothy Williams, Abhijeet Dhoble, Won-Keun Kim, Enrico Ferrari, Marco Barbanti, E Mara Vollema, Antonio Miceli, Cristina Giannini, Guiherme F Attizzani, William K F Kong, Enrique Gutierrez-Ibanes, Victor Alfonso Jimenez Diaz, Harindra C Wijeysundera, Hidehiro Kaneko, Tarun Chakravarty, Moody Makar, Horst Sievert, Christian Hengstenberg, Bernard D Prendergast, Flavien Vincent, Mohamed Abdel-Wahab, Luis Nombela-Franco, Miriam Silaschi, Giuseppe Tarantini, Christian Butter, Stephan M Ensminger, David Hildick-Smith, Anna Sonia Petronio, Wei-Hsian Yin, Federico De Marco, Luca Testa, Nicolas M Van Mieghem, Brian K Whisenant, Karl-Heinz Kuck, Antonio Colombo, Saibal Kar, Cesar Moris, Victoria Delgado, Francesco Maisano, Fabian Nietlispach, Michael J Mack, Joachim Schofer, Ulrich Schaefer, Jeroen J Bax, Christian Frerker, Azeem Latib, Raj R Makkar
BACKGROUND: Limited data exist about safety and efficacy of transcatheter aortic valve replacement (TAVR) in patients with pure native aortic regurgitation (AR). OBJECTIVES: This study sought to compare the outcomes of TAVR with early- and new-generation devices in symptomatic patients with pure native AR. METHODS: From the pure native AR TAVR multicenter registry, procedural and clinical outcomes were assessed according to VARC-2 criteria and compared between early- and new-generation devices...
December 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29191025/progress-and-future-direction-of-chromosome-centric-human-proteome-project
#7
Young-Ki Paik, Christopher M Overall, Eric W Deutsch, Jennifer E Van Eyk, Gilbert S Omenn
This special issue of JPR celebrates the fifth anniversary of the Chromosome-Centric Human Proteome Project (C-HPP). We present 27 manuscripts in four categories: (i) Metrics of Progress and Resources, (ii) Missing Protein Detection and Validation, (iii) Analytical Methods and Quality Assessment, and (iv) Protein Functions and Disease. We briefly introduce key messages from each paper, mostly from C-HPP teams and some from the Biology and Disease-driven HPP. From the first few months of the C-HPP NeXt-MP50 Missing Proteins Challenge, authors report 73 missing protein detections that meet the HPP guidelines using several novel approaches...
December 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29159575/-dog-and-bva-guideline-no-24b-noninfectious-uveitis-posterior
#8
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
November 20, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29156493/virtual-reality-for-stroke-rehabilitation
#9
REVIEW
Kate E Laver, Belinda Lange, Stacey George, Judith E Deutsch, Gustavo Saposnik, Maria Crotty
BACKGROUND: Virtual reality and interactive video gaming have emerged as recent treatment approaches in stroke rehabilitation with commercial gaming consoles in particular, being rapidly adopted in clinical settings. This is an update of a Cochrane Review published first in 2011 and then again in 2015. OBJECTIVES: Primary objective: to determine the efficacy of virtual reality compared with an alternative intervention or no intervention on upper limb function and activity...
November 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29141269/-practice-guideline-autoimmune-liver-diseases-awmf-reg-no-021-27
#10
(no author information available yet)
The guideline was created under the leadership of the DGVS and with participation of neighbouring scientific societies and is intended as a practical aid for the diagnosis and therapy of autoimmune liver diseases. The aim is to represent the current state of science, promote the recognition of the disease and improve the treatment of patients.
November 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29134879/corrigendum
#11
(no author information available yet)
Evans, E.C., Deutsch, N.L., Drake, E., and Bullock, L. (2017). Nurse-Patient Interaction as a Treatment for Antepartum Depression: A Mixed-Methods Analysis. Journal of the American Psychiatric Nurses Association, 23, 347-359. (Original doi: 10.1177/1078390317705449) In the September/October issue of JAPNA the reference for Peplau (1997) was incorrectly listed and cited throughout the paper. This has been updated in the online version. The correct reference should have been: Peplau, H. E. (1952). Interpersonal relations in nursing: A conceptual frame of reference for psychodynamic nursing...
November 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/29133944/region-and-cell-type-resolved-quantitative-proteomic-map-of-the-human-heart
#12
Sophia Doll, Martina Dreßen, Philipp E Geyer, Daniel N Itzhak, Christian Braun, Stefanie A Doppler, Florian Meier, Marcus-Andre Deutsch, Harald Lahm, Rüdiger Lange, Markus Krane, Matthias Mann
The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here, we determine the healthy human heart proteome by measuring 16 anatomical regions and three major cardiac cell types by high-resolution mass spectrometry-based proteomics. From low microgram sample amounts, we quantify over 10,700 proteins in this high dynamic range tissue. We combine copy numbers per cell with protein organellar assignments to build a model of the heart proteome at the subcellular level...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29129594/are-resting-state-spectral-power-measures-related-to-executive-functions-in-healthy-young-adults
#13
Shirley Gordon, Doron Todder, Inbal Deutsch, Dror Garbi, Nir Getter, Nachshon Meiran
Resting-state electroencephalogram (rsEEG) has been found to be associated with psychopathology, intelligence, problem solving, academic performance and is sometimes used as a supportive physiological indicator of enhancement in cognitive training interventions (e.g. neurofeedback, working memory training). In the current study, we measured rsEEG spectral power measures (relative power, between-band ratios and asymmetry) in one hundred sixty five young adults who were also tested on a battery of executive function (EF)...
November 9, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29105658/representativeness-of-the-spinal-cord-injury-model-systems-national-database
#14
Jessica M Ketchum, Jeffrey P Cuthbert, Anne Deutsch, Yuying Chen, Susan Charlifue, David Chen, Marcel P Dijkers, James E Graham, Allen W Heinemann, Daniel P Lammertse, Gale G Whiteneck
STUDY DESIGN: Secondary analysis of prospectively collected observational data. OBJECTIVES: To assess the representativeness of the Spinal Cord Injury Model Systems National Database (SCIMS-NDB) of all adults aged 18 years or older receiving inpatient rehabilitation in the United States (US) for new onset traumatic spinal cord injury (TSCI). SETTING: Inpatient rehabilitation centers in the US. METHODS: We compared demographic, functional status, and injury characteristics (nine categorical variables comprising of 46 categories and two continuous variables) between the SCIMS-NDB (N = 5969) and UDS-PRO/eRehabData (N = 99,142) cases discharged from inpatient rehabilitation in 2000-2010...
November 6, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29098342/preoperative-evaluation-of-adult-patients-before-elective-noncardiothoracic-surgery-joint-recommendation-of-the-german-society-of-anesthesiology-and-intensive-care-medicine-the-german-society-of-surgery-and-the-german-society-of-internal-medicine
#15
REVIEW
B Zwissler
Evaluation of the patient's medical history and a physical examination are the cornerstones of risk assessment prior to elective surgery, and may help to optimize the patient's preoperative medical condition and guide perioperative management. Whether performance of additional technical tests (e. g., blood chemistry, electrocardiography, spirometry, chest x‑ray) can contribute to reduction of the perioperative risk is often not well known or controversial. Similarly, there is considerable uncertainty among anesthesiologists, internists, and surgeons with respect to perioperative management of the patient's long-term medication...
November 2, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29096863/lipidological-competence-centres-and-networks-future-perspectives-to-improve-healthcare-of-patients-with-disorders-of-lipid-metabolism
#16
Franz Heigl, Tobias Pflederer, Volker Schettler, Peter Grützmacher, Ulrich Julius, Jens Ringel, Tilmann David-Walek, Reinhard Hettich, Norbert Lotz, Harduin Reeg, Markus Graf, Hans-Ulrich Klör
BACKGROUND: Numerous healthcare studies have shown that more than 90% of all patients with dyslipidaemia are not treated adequately. OBJECTIVES: The "Deutsche Gesellschaft zur Bekämpfung von Fettstoffwechselstörungen und ihren Folgeerkrankungen (DGFF)" [German Society of Lipidology], a non-profit professional membership organization, has already made a series of efforts to improve the care of patients suffering from dyslipidaemia. A recent outcome is the nationwide implementation and certification of Lipidological Competence Centres and Networks (LCCNs)...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29065919/diabetes-related-information-seeking-behaviour-a-systematic-review
#17
Silke Kuske, Tim Schiereck, Sandra Grobosch, Andrea Paduch, Sigrid Droste, Sarah Halbach, Andrea Icks
BACKGROUND: Information-seeking behaviour is necessary to improve knowledge on diabetes therapy and complications. Combined with other self-management skills and autonomous handling of the disease, it is essential for achieving treatment targets. However, a systematic review addressing this topic is lacking. The aims of this systematic review were to identify and analyse existing knowledge of information-seeking behaviour: (1) types information-seeking behaviour, (2) information sources, (3) the content of searched information, and (4) associated variables that may affect information-seeking behaviour...
October 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29058153/effects-of-growth-hormone-treatment-on-adult-height-in-severely-short-children-with-x-linked-hypophosphatemic-rickets
#18
Nadine Meyerhoff, Dieter Haffner, Hagen Staude, Elke Wühl, Michaela Marx, Rolf Beetz, Uwe Querfeld, Martin Holder, Heiko Billing, Wolfgang Rabl, Carmen Schröder, Olaf Hiort, Jürgen H Brämswig, Annette Richter-Unruh, Dirk Schnabel, Miroslav Živičnjak
BACKGROUND: We recently showed that a 3-year growth hormone (GH) treatment improves linear growth in severely short children with X-linked hypophosphatemic rickets (XLH). It is unknown if GH therapy increases adult height in XLH patients. METHODS: We carried out a follow-up analysis of a randomized controlled open-label GH study in short prepubertal children with XLH on phosphate and active vitamin D treatment. The changes in SD scores (SDS) of height, sitting height, leg and arm length, and sitting height index (i...
October 20, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29045516/navigating-the-highlights-of-phase-iii-trials-a-watchful-eye-on-evidence-based-radiotherapy
#19
J C Trone, S Espenel, A Rehailia-Blanchard, E Guillaume, N Vial, C Rancoule, C Rodriguez-Lafrasse, M Ben Mrad, A El Meddeb Hamrouni, E Ollier, C Chargari, E Deutsch, A Vallard, N Magné
Background: Phase III randomized controlled trials (RCTs) are the cornerstone of evidence-based oncology. However, there is no exhaustive review describing the radiotherapy RTCs characteristics. The objective of the present study was to describe features of all phase III RCTs including at least a radiation therapy. Methods and materials: Requests were performed in the Medline database (via PubMed). The latest update was performed in April 2016, using the following MESH terms: 'clinical trials: phase III as topic', 'radiotherapy', 'brachytherapy', as keywords...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29041986/fluorescence-optical-imaging-in-pediatric-patients-with-inflammatory-and-non-inflammatory-joint-diseases-a-comparative-study-with-ultrasonography
#20
Marisa Christin Beck, Anne-Marie Glimm, Sarah Ohrndorf, Kirsten Minden, Ralf Trauzeddel, Stephanie Gabriele Werner, Gerd Horneff, Marina Backhaus, Gerd Rüdiger Burmester, Tilmann Kallinich, Hermann Girschick, Jens Klotsche
BACKGROUND: Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wrist and finger joints. Objectives of this study were to compare FOI with ultrasonography (US, by gray-scale (GS) and power Doppler (PD)) and clinical examination (CE) and to estimate the predictive power of FOI for discrimination between inflammatory and non-inflammatory juvenile joint diseases...
October 17, 2017: Arthritis Research & Therapy
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