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https://www.readbyqxmd.com/read/29659311/a-knowledge-translation-intervention-designed-using-audit-and-feedback-and-the-theoretical-domains-framework-for-physical-therapists-working-in-inpatient-rehabilitation-a-case-report
#1
Wendy Romney, Nancy Salbach, James Scott Parrott, Judith E Deutsch
BACKGROUND AND PURPOSE: Little is known about the process of engaging key stakeholders to select and design a knowledge translation (KT) intervention to increase the use of an outcome measure using audit and feedback. The purpose of this case report was to describe the development of a KT intervention designed with organizational support to increase physical therapists' (PTs) use of a selected outcome measure in an inpatient sub-acute rehabilitation hospital. CASE DESCRIPTION: Eleven PTs who worked at a sub-acute rehabilitation hospital participated...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29599716/atrophy-in-the-thalamus-but-not-cerebellum-is-specific-for-c9orf72-ftd-and-als-patients-an-atlas-based-volumetric-mri-study
#2
Sonja Schönecker, Christiane Neuhofer, Markus Otto, Albert Ludolph, Jan Kassubek, Bernhard Landwehrmeyer, Sarah Anderl-Straub, Elisa Semler, Janine Diehl-Schmid, Catharina Prix, Christian Vollmar, Juan Fortea, Hans-Jürgen Huppertz, Thomas Arzberger, Dieter Edbauer, Berend Feddersen, Marianne Dieterich, Matthias L Schroeter, Alexander E Volk, Klaus Fließbach, Anja Schneider, Johannes Kornhuber, Manuel Maler, Johannes Prudlo, Holger Jahn, Tobias Boeckh-Behrens, Adrian Danek, Thomas Klopstock, Johannes Levin
Background: The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. Thalamus and cerebellum seem to be preferentially affected by the dipeptide repeat pathology unique to C9orf72 mutation carriers. Objective: This study aimed to determine if mutation carriers showed an enhanced degree of thalamic and cerebellar atrophy compared to sporadic patients or healthy controls...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29572685/-statement-and-recommendation-of-the-professional-association-of-german-ophthalmologists-bva-the-german-ophthalmological-society-dog-and-the-german-retina-society-rg-on-central-serous-chorioretinopathy-situation-january-2018
#3
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
March 23, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29557330/efficiency-of-a-malaria-reactive-test-and-treat-program-in-southern-zambia-a-prospective-observational-study
#4
Molly Deutsch-Feldman, Harry Hamapumbu, Jailos Lubinda, Michael Musonda, Ben Katowa, Kelly M Searle, Tamaki Kobayashi, Timothy M Shields, Jennifer C Stevenson, Philip E Thuma, William J Moss, For The Southern Africa International Centers Of Excellence For Malaria Research
To improve malaria surveillance and achieve elimination, the Zambian National Malaria Elimination Program implemented a reactive test-and-treat program in Southern Province in 2013 in which individuals with rapid diagnostic test (RDT)-confirmed malaria are followed-up at their home within 1 week of diagnosis. Individuals present at the index case household and those residing within 140 m of the index case are tested with an RDT and treated with artemether-lumefantrine if positive. This study evaluated the efficiency of this reactive test-and-treat strategy by characterizing infected individuals missed by the RDT and the current screening radius...
March 19, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29538411/test-performance-and-acceptability-of-self-versus-provider-collected-swabs-for-high-risk-hpv-dna-testing-in-female-to-male-trans-masculine-patients
#5
Sari L Reisner, Madeline B Deutsch, Sarah M Peitzmeier, Jaclyn M White Hughto, Timothy P Cavanaugh, Dana J Pardee, Sarah A McLean, Lori A Panther, Marcy Gelman, Matthew J Mimiaga, Jennifer E Potter
BACKGROUND: High-risk human papillomavirus (hrHPV) causes virtually all cervical cancers. Trans masculine (TM) people (those assigned female at birth who identify with a gender other than female) have low uptake of conventional cervical cancer screening. Self-collected hrHPV DNA testing has high levels of acceptability among cisgender (non-transgender) females and may support increased cervical cancer screening uptake in TM individuals. OBJECTIVE: To assess the test performance and acceptability of self-collected vaginal specimens in comparison to provider-collected cervical swabs for hrHPV DNA detection in TM individuals ages 21-64 years...
2018: PloS One
https://www.readbyqxmd.com/read/29531087/fatty-acid-binding-protein-5-controls-retrograde-endocannabinoid-signaling-at-central-glutamate-synapses
#6
Samir Haj-Dahmane, Roh-Yu Shen, Matthew W Elmes, Keith Studholme, Martha P Kanjiya, Diane Bogdan, Panayotis K Thanos, Jeremy T Miyauchi, Stella E Tsirka, Dale G Deutsch, Martin Kaczocha
Endocannabinoids (eCBs) are lipid-signaling molecules involved in the regulation of numerous behaviors and physiological functions. Released by postsynaptic neurons, eCBs mediate retrograde modulation of synaptic transmission and plasticity by activating presynaptic cannabinoid receptors. While the cellular mechanisms by which eCBs control synaptic function have been well characterized, the mechanisms controlling their retrograde synaptic transport remain unknown. Here, we demonstrate that fatty-acid-binding protein 5 (FABP5), a canonical intracellular carrier of eCBs, is indispensable for retrograde eCB transport in the dorsal raphe nucleus (DRn)...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29523017/-guideline-for-the-diagnosis-and-treatment-of-copd-patients-issued-by-the-german-respiratory-society-and-the-german-atemwegsliga-in-cooperation-with-the-austrian-society-of-pneumology
#7
C Vogelmeier, R Buhl, O Burghuber, C-P Criée, S Ewig, J Godnic-Cvar, S Hartl, F Herth, P Kardos, K Kenn, D Nowak, K F Rabe, M Studnicka, H Watz, T Welte, W Windisch, H Worth
This document is a revision of the guideline for diagnosis and treatment of COPD that replaces the version from 2007. A multitude of recent reports regarding risk factors, diagnosis, assessment, prevention and pharmacological as well as non-pharmacological treatment options made a major revision mandatory. The new guideline is based on the GOLD document taking into account specifics in Germany and Austria.
March 9, 2018: Pneumologie
https://www.readbyqxmd.com/read/29520492/-statement-from-the-bva-the-dog-and-the-rg-on-treatment-of-choroidal-neovascularization-in-diseases-other-than-neovascular-age-related-macular-degeneration-october-2017
#8
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
March 8, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29505959/wrong-site-nerve-blocks-a-systematic-literature-review-to-guide-principles-for-prevention
#9
REVIEW
Ellen S Deutsch, Robert A Yonash, Donald E Martin, Joshua H Atkins, Theresa V Arnold, Christina M Hunt
STUDY OBJECTIVE: Wrong-site nerve blocks (WSBs) are a significant, though rare, source of perioperative morbidity. WSBs constitute the most common type of perioperative wrong-site procedure reported to the Pennsylvania Patient Safety Authority. This systematic literature review aggregates information about the incidence, patient consequences, and conditions that contribute to WSBs, as well as evidence-based methods to prevent them. DESIGN: A systematic search of English-language publications was performed, using the PRISMA process...
March 2, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29466657/chemiluminescent-biosensors-for-detection-of-second-messenger-cyclic-di-gmp
#10
Andrew B Dippel, Wyatt A Anderson, Robert S Evans, Samuel Deutsch, Ming C Hammond
Bacteria colonize highly diverse and complex environments, from gastrointestinal tracts, to soil and plant surfaces. This colonization process is controlled in part by the intracellular signal cyclic di-GMP, which regulates bacterial motility and biofilm formation. To interrogate cyclic di-GMP signaling networks, a variety of fluorescent biosensors for live cell imaging of cyclic di-GMP have been developed. However, the need for external illumination precludes the use of these tools for imaging bacteria in their natural environments, including in deep tissues of whole organisms and in samples that are highly autofluorescent or photosensitive...
February 21, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29450623/-statement-of-the-bva-and-dog-on-eye-examinations-in-patients-with-high-visual-defects-status-january-2018
#11
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29449629/publisher-correction-human-%C3%AE-%C3%AE-t-cells-are-quickly-reconstituted-after-stem-cell-transplantation-and-show-adaptive-clonal-expansion-in-response-to-viral-infection
#12
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker, Linda Oberdörfer, Annika Reinhardt, Inga Ravens, Maleen Beck, Robert Geffers, Constantin von Kaisenberg, Michael Heuser, Felicitas Thol, Arnold Ganser, Reinhold Förster, Christian Koenecke, Immo Prinz
In the version of this article initially published, a source of funding (Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.)) was not included in the Acknowledgments section. The correct statement is as follows: "Supported by Deutsche Forschungsgemeinschaft, (SFB900/B8 to C.K. and I.P.; and PR727/4-1 to I.P.), Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.) and the German Federal Ministry of Education and Research (01EO1302 to C.S.-F., C.K. and I...
February 14, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29443962/a-programmable-two-qubit-quantum-processor-in-silicon
#13
T F Watson, S G J Philips, E Kawakami, D R Ward, P Scarlino, M Veldhorst, D E Savage, M G Lagally, Mark Friesen, S N Coppersmith, M A Eriksson, L M K Vandersypen
Now that it is possible to achieve measurement and control fidelities for individual quantum bits (qubits) above the threshold for fault tolerance, attention is moving towards the difficult task of scaling up the number of physical qubits to the large numbers that are needed for fault-tolerant quantum computing. In this context, quantum-dot-based spin qubits could have substantial advantages over other types of qubit owing to their potential for all-electrical operation and ability to be integrated at high density onto an industrial platform...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29427012/-blood-pressure-targets-the-lower-the-better-does-not-suit-all
#14
REVIEW
U Hoffmann
BACKGROUND: The systolic blood pressure intervention trial (SPRINT) published in 2015 has opened up new discussions on whether a lower blood pressure target as recommended by the current guidelines would be better for some patient groups. OBJECTIVES: To review patient groups in which lower blood pressure targets would not be better. MATERIALS AND METHODS: The results of SPRINT, its post-hoc and subgroup analyses, other studies and newer studies, as well as metaanalyses on the topic of blood pressure targets are reviewed and discussed...
February 9, 2018: Der Internist
https://www.readbyqxmd.com/read/29373871/-dog-and-bva-guideline-no-%C3%A2-24b-noninfectious-uveitis-posterior
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29355570/a-novel-plasmid-psaa0430-08-from-streptococcus-anginosus-subsp-anginosus-strain-0430-08
#16
Atsushi Tabata, Douglas Deutsch, Seiya Otsuka, Kathleen Verratti, Toshifumi Tomoyasu, Hideaki Nagamune, Vincent A Fischetti
Mobile genetic elements (MGEs) are the genetic material often involved in the interspecies and intraspecies genetic transduction in bacteria. However, little is known about MGEs in the Anginosus group of streptococci (AGS), one of the streptococcal groups found in the oral cavity of humans. We looked for the presence of MGEs in Streptococcus anginosus subsp. anginosus (SAA), a representative species belonging to AGS, and found a novel plasmid from SAA strain 0430-08. This plasmid was 7038bp and ~31% G/C content which we named pSAA0430-08, and examined its genetic structure and characteristics...
January 2018: Plasmid
https://www.readbyqxmd.com/read/29345225/indications-for-the-surgical-management-of-benign-goiter-in-adults
#17
Detlef K Bartsch, Markus Luster, Heinz J Buhr, Dietmar Lorenz, Christoph-Thomas Germer, Peter E Goretzki
BACKGROUND: Thyroidectomy is still three to six times more common in Germany than in the USA, Great Britain, and the Scandinavian countries. Thus, the question is often asked whether thyroidectomy in Germany is being performed for the correct indications. METHODS: This review is based on studies and guidelines containing information on the indications for surgery in benign goiter and Graves' disease; these publications were retrieved by a systematic literature search in the Medline and Cochrane Library databases (1990-2016)...
January 8, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29341032/-epidemiology-diagnosis-and-treatment-of-adult-patients-with-nosocomial-pneumonia-update-2017-s3-guideline-of-the-german-society-for-anaesthesiology-and-intensive-care-medicine-the-german-society-for-infectious-diseases-the-german-society-for-hygiene-and-microbiology
#18
K Dalhoff, M Abele-Horn, S Andreas, M Deja, S Ewig, P Gastmeier, S Gatermann, H Gerlach, B Grabein, C P Heußel, G Höffken, M Kolditz, E Kramme, H Kühl, C Lange, K Mayer, I Nachtigall, M Panning, M Pletz, P-M Rath, G Rohde, S Rosseau, B Schaaf, D Schreiter, H Schütte, H Seifert, C Spies, T Welte
Nosocomial pneumonia (HAP) is a frequent complication of hospital care. Most data are available on ventilator-associated pneumonia. However, infections on general wards are increasing. A central issue are infections with multidrug resistant (MDR) pathogens which are difficult to treat in the empirical setting potentially leading to inappropriate use of antimicrobial therapy.This guideline update was compiled by an interdisciplinary group on the basis of a systematic literature review. Recommendations are made according to GRADE giving guidance for the diagnosis and treatment of HAP on the basis of quality of evidence and benefit/risk ratio...
January 2018: Pneumologie
https://www.readbyqxmd.com/read/29329280/status-of-hiv-epidemic-control-among-adolescent-girls-and-young-women-aged-15-24-years-seven-african-countries-2015-2017
#19
Kristin Brown, Daniel B Williams, Steve Kinchen, Suzue Saito, Elizabeth Radin, Hetal Patel, Andrea Low, Stephen Delgado, Owen Mugurungi, Godfrey Musuka, Beth A Tippett Barr, E Amaka Nwankwo-Igomu, Leala Ruangtragool, Avi J Hakim, Thokozani Kalua, Rose Nyirenda, Gertrude Chipungu, Andrew Auld, Evelyn Kim, Danielle Payne, Nellie Wadonda-Kabondo, Christine West, Elizabeth Brennan, Beth Deutsch, Anteneh Worku, Sasi Jonnalagadda, Lloyd B Mulenga, Kumbutso Dzekedzeke, Danielle T Barradas, Haotian Cai, Sundeep Gupta, Stanley Kamocha, Margaret A Riggs, Karampreet Sachathep, Wilford Kirungi, Joshua Musinguzi, Alex Opio, Sam Biraro, Elizabeth Bancroft, Jennifer Galbraith, Herbert Kiyingi, Mansoor Farahani, Wolfgang Hladik, Edith Nyangoma, Choice Ginindza, Zandile Masangane, Fortune Mhlanga, Zandile Mnisi, Pasipamire Munyaradzi, Amos Zwane, Sean Burke, Felix B Kayigamba, Harriet Nuwagaba-Biribonwoha, Ruben Sahabo, Trong T Ao, Chiara Draghi, Caroline Ryan, Neena M Philip, Fausta Mosha, Aroldia Mulokozi, Phausta Ntigiti, Angela A Ramadhani, Geoffrey R Somi, Cecilia Makafu, Veronicah Mugisha, Julius Zelothe, Kayla Lavilla, David W Lowrance, Rennatus Mdodo, Elizabeth Gummerson, Paul Stupp, Kyaw Thin, Koen Frederix, Stefania Davia, Amee M Schwitters, Stephen D McCracken, Yen T Duong, David Hoos, Bharat Parekh, Jessica E Justman, Andrew C Voetsch
In 2016, an estimated 1.5 million females aged 15-24 years were living with human immunodeficiency virus (HIV) infection in Eastern and Southern Africa, where the prevalence of HIV infection among adolescent girls and young women (3.4%) is more than double that for males in the same age range (1.6%) (1). Progress was assessed toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 2020 targets for adolescent girls and young women in sub-Saharan Africa (90% of those with HIV infection aware of their status, 90% of HIV-infected persons aware of their status on antiretroviral treatment [ART], and 90% of those on treatment virally suppressed [HIV viral load <1,000 HIV RNA copies/mL]) (2) using data from recent Population-based HIV Impact Assessment (PHIA) surveys in seven countries...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29322536/two-step-estimation-in-ratio-of-mediator-probability-weighted-causal-mediation-analysis
#20
Edward Bein, Jonah Deutsch, Guanglei Hong, Kristin E Porter, Xu Qin, Cheng Yang
This study investigates appropriate estimation of estimator variability in the context of causal mediation analysis that employs propensity score-based weighting. Such an analysis decomposes the total effect of a treatment on the outcome into an indirect effect transmitted through a focal mediator and a direct effect bypassing the mediator. Ratio-of-mediator-probability weighting estimates these causal effects by adjusting for the confounding impact of a large number of pretreatment covariates through propensity score-based weighting...
April 15, 2018: Statistics in Medicine
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