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https://www.readbyqxmd.com/read/29450623/-statement-of-the-bva-and-dog-on-eye-examinations-in-patients-with-high-visual-defects-status-january-2018
#1
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29449629/publisher-correction-human-%C3%AE-%C3%AE-t-cells-are-quickly-reconstituted-after-stem-cell-transplantation-and-show-adaptive-clonal-expansion-in-response-to-viral-infection
#2
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker, Linda Oberdörfer, Annika Reinhardt, Inga Ravens, Maleen Beck, Robert Geffers, Constantin von Kaisenberg, Michael Heuser, Felicitas Thol, Arnold Ganser, Reinhold Förster, Christian Koenecke, Immo Prinz
In the version of this article initially published, a source of funding (Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.)) was not included in the Acknowledgments section. The correct statement is as follows: "Supported by Deutsche Forschungsgemeinschaft, (SFB900/B8 to C.K. and I.P.; and PR727/4-1 to I.P.), Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.) and the German Federal Ministry of Education and Research (01EO1302 to C.S.-F., C.K. and I...
February 14, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29443962/a-programmable-two-qubit-quantum-processor-in-silicon
#3
T F Watson, S G J Philips, E Kawakami, D R Ward, P Scarlino, M Veldhorst, D E Savage, M G Lagally, Mark Friesen, S N Coppersmith, M A Eriksson, L M K Vandersypen
Now that it is possible to achieve measurement and control fidelities for individual quantum bits (qubits) above the threshold for fault tolerance, attention is moving towards the difficult task of scaling up the number of physical qubits to the large numbers that are needed for fault-tolerant quantum computing. In this context, quantum-dot-based spin qubits could have substantial advantages over other types of qubit owing to their potential for all-electrical operation and ability to be integrated at high density onto an industrial platform...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29427012/-blood-pressure-targets-the-lower-the-better-does-not-suit-all
#4
REVIEW
U Hoffmann
BACKGROUND: The systolic blood pressure intervention trial (SPRINT) published in 2015 has opened up new discussions on whether a lower blood pressure target as recommended by the current guidelines would be better for some patient groups. OBJECTIVES: To review patient groups in which lower blood pressure targets would not be better. MATERIALS AND METHODS: The results of SPRINT, its post-hoc and subgroup analyses, other studies and newer studies, as well as metaanalyses on the topic of blood pressure targets are reviewed and discussed...
February 9, 2018: Der Internist
https://www.readbyqxmd.com/read/29373871/-dog-and-bva-guideline-no-%C3%A2-24b-noninfectious-uveitis-posterior
#5
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29355570/a-novel-plasmid-psaa0430-08-from-streptococcus-anginosus-subsp-anginosus-strain-0430-08
#6
Atsushi Tabata, Douglas Deutsch, Seiya Otsuka, Kathleen Verratti, Toshifumi Tomoyasu, Hideaki Nagamune, Vincent A Fischetti
Mobile genetic elements (MGEs) are the genetic material often involved in the interspecies and intraspecies genetic transduction in bacteria. However, little is known about MGEs in the Anginosus group of streptococci (AGS), one of the streptococcal groups found in the oral cavity of humans. We looked for the presence of MGEs in Streptococcus anginosus subsp. anginosus (SAA), a representative species belonging to AGS, and found a novel plasmid from SAA strain 0430-08. This plasmid was 7038bp and ~31% G/C content which we named pSAA0430-08, and examined its genetic structure and characteristics...
January 17, 2018: Plasmid
https://www.readbyqxmd.com/read/29345225/indications-for-the-surgical-management-of-benign-goiter-in-adults
#7
Detlef K Bartsch, Markus Luster, Heinz J Buhr, Dietmar Lorenz, Christoph-Thomas Germer, Peter E Goretzki
BACKGROUND: Thyroidectomy is still three to six times more common in Germany than in the USA, Great Britain, and the Scandinavian countries. Thus, the question is often asked whether thyroidectomy in Germany is being performed for the correct indications. METHODS: This review is based on studies and guidelines containing information on the indications for surgery in benign goiter and Graves' disease; these publications were retrieved by a systematic literature search in the Medline and Cochrane Library databases (1990-2016)...
January 8, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29341032/-epidemiology-diagnosis-and-treatment-of-adult-patients-with-nosocomial-pneumonia-update-2017-s3-guideline-of-the-german-society-for-anaesthesiology-and-intensive-care-medicine-the-german-society-for-infectious-diseases-the-german-society-for-hygiene-and-microbiology
#8
K Dalhoff, M Abele-Horn, S Andreas, M Deja, S Ewig, P Gastmeier, S Gatermann, H Gerlach, B Grabein, C P Heußel, G Höffken, M Kolditz, E Kramme, H Kühl, C Lange, K Mayer, I Nachtigall, M Panning, M Pletz, P-M Rath, G Rohde, S Rosseau, B Schaaf, D Schreiter, H Schütte, H Seifert, C Spies, T Welte
Nosocomial pneumonia (HAP) is a frequent complication of hospital care. Most data are available on ventilator-associated pneumonia. However, infections on general wards are increasing. A central issue are infections with multidrug resistant (MDR) pathogens which are difficult to treat in the empirical setting potentially leading to inappropriate use of antimicrobial therapy.This guideline update was compiled by an interdisciplinary group on the basis of a systematic literature review. Recommendations are made according to GRADE giving guidance for the diagnosis and treatment of HAP on the basis of quality of evidence and benefit/risk ratio...
January 2018: Pneumologie
https://www.readbyqxmd.com/read/29329280/status-of-hiv-epidemic-control-among-adolescent-girls-and-young-women-aged-15-24-years-seven-african-countries-2015-2017
#9
Kristin Brown, Daniel B Williams, Steve Kinchen, Suzue Saito, Elizabeth Radin, Hetal Patel, Andrea Low, Stephen Delgado, Owen Mugurungi, Godfrey Musuka, Beth A Tippett Barr, E Amaka Nwankwo-Igomu, Leala Ruangtragool, Avi J Hakim, Thokozani Kalua, Rose Nyirenda, Gertrude Chipungu, Andrew Auld, Evelyn Kim, Danielle Payne, Nellie Wadonda-Kabondo, Christine West, Elizabeth Brennan, Beth Deutsch, Anteneh Worku, Sasi Jonnalagadda, Lloyd B Mulenga, Kumbutso Dzekedzeke, Danielle T Barradas, Haotian Cai, Sundeep Gupta, Stanley Kamocha, Margaret A Riggs, Karampreet Sachathep, Wilford Kirungi, Joshua Musinguzi, Alex Opio, Sam Biraro, Elizabeth Bancroft, Jennifer Galbraith, Herbert Kiyingi, Mansoor Farahani, Wolfgang Hladik, Edith Nyangoma, Choice Ginindza, Zandile Masangane, Fortune Mhlanga, Zandile Mnisi, Pasipamire Munyaradzi, Amos Zwane, Sean Burke, Felix B Kayigamba, Harriet Nuwagaba-Biribonwoha, Ruben Sahabo, Trong T Ao, Chiara Draghi, Caroline Ryan, Neena M Philip, Fausta Mosha, Aroldia Mulokozi, Phausta Ntigiti, Angela A Ramadhani, Geoffrey R Somi, Cecilia Makafu, Veronicah Mugisha, Julius Zelothe, Kayla Lavilla, David W Lowrance, Rennatus Mdodo, Elizabeth Gummerson, Paul Stupp, Kyaw Thin, Koen Frederix, Stefania Davia, Amee M Schwitters, Stephen D McCracken, Yen T Duong, David Hoos, Bharat Parekh, Jessica E Justman, Andrew C Voetsch
In 2016, an estimated 1.5 million females aged 15-24 years were living with human immunodeficiency virus (HIV) infection in Eastern and Southern Africa, where the prevalence of HIV infection among adolescent girls and young women (3.4%) is more than double that for males in the same age range (1.6%) (1). Progress was assessed toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 2020 targets for adolescent girls and young women in sub-Saharan Africa (90% of those with HIV infection aware of their status, 90% of HIV-infected persons aware of their status on antiretroviral treatment [ART], and 90% of those on treatment virally suppressed [HIV viral load <1,000 HIV RNA copies/mL]) (2) using data from recent Population-based HIV Impact Assessment (PHIA) surveys in seven countries...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29322536/two-step-estimation-in-ratio-of-mediator-probability-weighted-causal-mediation-analysis
#10
Edward Bein, Jonah Deutsch, Guanglei Hong, Kristin E Porter, Xu Qin, Cheng Yang
This study investigates appropriate estimation of estimator variability in the context of causal mediation analysis that employs propensity score-based weighting. Such an analysis decomposes the total effect of a treatment on the outcome into an indirect effect transmitted through a focal mediator and a direct effect bypassing the mediator. Ratio-of-mediator-probability weighting estimates these causal effects by adjusting for the confounding impact of a large number of pretreatment covariates through propensity score-based weighting...
January 10, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29280540/contact-killing-and-antimicrobial-properties-of-copper
#11
REVIEW
Marin Vincent, Raphaël E Duval, Philippe Hartemann, Marc Engels-Deutsch
With the emergence of antibiotic resistance, the interest for antimicrobial agents has recently increased again in public health. Copper was recognized in 2008 by the United States Environmental Protection Agency (EPA) as the first metallic antimicrobial agent. This led to many investigations of the various properties of copper as an antibacterial, antifungal and antiviral agent. This review summarizes the latest findings about "contact killing", the mechanism of action of copper nanoparticles and the different ways microorganisms develop resistance to copper...
December 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29278927/time-since-injury-limits-but-does-not-prevent-improvement-and-maintenance-of-gains-in-balance-in-chronic-stroke
#12
Roberto Llorens, Enrique Noé, Mariano Alcañiz, Judith E Deutsch
OBJECTIVE: To determine the influence of time since injury on the efficacy and maintenance of gains of rehabilitation of balance after stroke. METHOD: Forty-seven participants were assigned to a least (6-12 months), a moderate (12-24 months), or a most chronic (>24 months) group. Participants trained for 20 one-hour sessions, administered three to five times a week, combining conventional physical therapy and visual feedback-based exercises that trained the ankle and hip strategies...
December 26, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29248760/individuals-with-borderline-personality-disorder-show-larger-preferred-social-distance-in-live-dyadic-interactions
#13
Sarah K Fineberg, Jacob Leavitt, Christopher D Landry, Eli S Neustadter, Rebecca E Lesser, Dylan S Stahl, Sasha Deutsch-Link, Philip R Corlett
Personal space regulation is a key component of effective social engagement. Personal space varies among individuals and with some mental health conditions. Simulated personal space intrusions in Borderline Personality Disorder (BPD) reveal larger preferred interpersonal distance in that setting. These findings led us to conduct the first test of live interpersonal distance preferences in symptoms in BPD. With direct observation of subjects' personal space behavior in the stop-distance paradigm, we found a 2-fold larger preferred interpersonal distance in BPD than control (n = 30, n = 23)...
November 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29233559/tumour-infiltrating-lymphocytes-and-prognosis-in-different-subtypes-of-breast-cancer-a-pooled-analysis-of-3771-patients-treated-with-neoadjuvant-therapy
#14
Carsten Denkert, Gunter von Minckwitz, Silvia Darb-Esfahani, Bianca Lederer, Barbara I Heppner, Karsten E Weber, Jan Budczies, Jens Huober, Frederick Klauschen, Jenny Furlanetto, Wolfgang D Schmitt, Jens-Uwe Blohmer, Thomas Karn, Berit M Pfitzner, Sherko Kümmel, Knut Engels, Andreas Schneeweiss, Arndt Hartmann, Aurelia Noske, Peter A Fasching, Christian Jackisch, Marion van Mackelenbergh, Peter Sinn, Christian Schem, Claus Hanusch, Michael Untch, Sibylle Loibl
BACKGROUND: Tumour-infiltrating lymphocytes (TILs) are predictive for response to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) and HER2-positive breast cancer, but their role in luminal breast cancer and the effect of TILs on prognosis in all subtypes is less clear. Here, we assessed the relevance of TILs for chemotherapy response and prognosis in patients with TNBC, HER2-positive breast cancer, and luminal-HER2-negative breast cancer. METHODS: Patients with primary breast cancer who were treated with neoadjuvant combination chemotherapy were included from six randomised trials done by the German Breast Cancer Group...
December 7, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29223359/in-niemann-pick-c1-mouse-models-glial-only-expression-of-the-normal-gene-extends-survival-much-further-than-do-changes-in-genetic-background-or-treatment-with-hydroxypropyl-beta-cyclodextrin
#15
Craig A Marshall, Dawn E Watkins-Chow, Giampiero Palladino, Gail Deutsch, Keshav Chandran, William J Pavan, Robert P Erickson
The Npc1nmf164 allele of Npc1 provides a mouse model for Niemann-Pick disease type C1 (NPC1), a genetic disease known to have a widely variable phenotype. The transfer of the Npc1nmf164 mutation from the C57BL/6J inbred strain to the BALB/cJ inbred strain increased the mean lifespan from 117.8days to 153.1days, confirming that the severity of the NPC1 phenotype is strongly influenced by genetic background. The transfer of another Npc1 allele, Npc1nih, to this background also extended survival of the homozygotes indicating that the modifying effect of BALB/cJ is not limited to a single allele of Npc1...
December 6, 2017: Gene
https://www.readbyqxmd.com/read/29217134/reirradiation-with-concurrent-bevacizumab-for-recurrent-high-grade-gliomas-in-adult-patients
#16
A Schernberg, F Dhermain, S Ammari, S N Dumont, J Domont, A Patrikidou, J Pallud, É Dezamis, É Deutsch, G Louvel
PURPOSE: To analyse feasibility, prognostic factors and patterns of recurrence after concurrent reirradiation and bevacizumab for recurrent high-grade gliomas. PATIENTS AND METHODS: Between 2009 and 2015, 35 patients (median 57-year-old; 21 men, 14 women) with WHO grade III (n=11) or grade IV (n=24) gliomas were included in this retrospective and consecutive single-centre study. All patients received bevacizumab (median number of treatments: 12) concomitant with reirradiation (median dose: 45Gy, median number of fractions: 18) for recurrence with median 22 months (range: 5...
December 4, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29216678/-guideline-for-the-diagnosis-and-treatment-of-asthma-guideline-of-the-german-respiratory-society-and-the-german-atemwegsliga-in-cooperation-with-the-paediatric-respiratory-society-and-the-austrian-society-of-pneumology
#17
R Buhl, R Bals, X Baur, D Berdel, C-P Criée, M Gappa, A Gillissen, T Greulich, P Haidl, E Hamelmann, P Kardos, K Kenn, L Klimek, S Korn, M Lommatzsch, H Magnussen, T Nicolai, D Nowak, O Pfaar, K F Rabe, J Riedler, T Ritz, K Schultz, A Schuster, T Spindler, R C Taube, K Taube, C Vogelmeier, A von Leupold, F Wantke, S Weise, J Wildhaber, H Worth, A Zacharasiewicz
The present guideline is a new version and an update of the guideline for the diagnosis and treatment of asthma, which replaces the previous version for german speaking countries from the year 2006. The wealth of new data on the pathophysiology and the phenotypes of asthma, and the expanded spectrum of diagnostic and therapeutic options necessitated a new version and an update. This guideline presents the current, evidence-based recommendations for the diagnosis and treatment of asthma, for children and adolescents as well as for adults with asthma...
December 2017: Pneumologie
https://www.readbyqxmd.com/read/29197019/-quality-indicators-for-pancreatic-surgery-scientific-derivation-and-clinical-relevance
#18
REVIEW
U F Wellner, R Grützmann, T Keck, N Nüssler, H E Witzigmann, H-J Buhr
Quality indicators are by definition indirect measures of quality. The selection for the field of pancreatic surgery was based on the clinical relevance and controllability, scientific evidence and the practicability of data acquisition. In terms of outcome quality, hospital mortality, the composite endpoint MTL30 (mortality-transfer-length of stay), and major complications (Clavien-Dindo classification grades 3b and 4) were chosen as being essential. With respect to structural quality, the presence of interventional radiology with constant availability was considered essential...
December 1, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29191323/transcatheter-aortic-valve-replacement-in-pure-native-aortic-valve-regurgitation
#19
MULTICENTER STUDY
Sung-Han Yoon, Tobias Schmidt, Sabine Bleiziffer, Niklas Schofer, Claudia Fiorina, Antonio J Munoz-Garcia, Ermela Yzeiraj, Ignacio J Amat-Santos, Didier Tchetche, Christian Jung, Buntaro Fujita, Antonio Mangieri, Marcus-Andre Deutsch, Timm Ubben, Florian Deuschl, Shingo Kuwata, Chiara De Biase, Timothy Williams, Abhijeet Dhoble, Won-Keun Kim, Enrico Ferrari, Marco Barbanti, E Mara Vollema, Antonio Miceli, Cristina Giannini, Guiherme F Attizzani, William K F Kong, Enrique Gutierrez-Ibanes, Victor Alfonso Jimenez Diaz, Harindra C Wijeysundera, Hidehiro Kaneko, Tarun Chakravarty, Moody Makar, Horst Sievert, Christian Hengstenberg, Bernard D Prendergast, Flavien Vincent, Mohamed Abdel-Wahab, Luis Nombela-Franco, Miriam Silaschi, Giuseppe Tarantini, Christian Butter, Stephan M Ensminger, David Hildick-Smith, Anna Sonia Petronio, Wei-Hsian Yin, Federico De Marco, Luca Testa, Nicolas M Van Mieghem, Brian K Whisenant, Karl-Heinz Kuck, Antonio Colombo, Saibal Kar, Cesar Moris, Victoria Delgado, Francesco Maisano, Fabian Nietlispach, Michael J Mack, Joachim Schofer, Ulrich Schaefer, Jeroen J Bax, Christian Frerker, Azeem Latib, Raj R Makkar
BACKGROUND: Limited data exist about safety and efficacy of transcatheter aortic valve replacement (TAVR) in patients with pure native aortic regurgitation (AR). OBJECTIVES: This study sought to compare the outcomes of TAVR with early- and new-generation devices in symptomatic patients with pure native AR. METHODS: From the pure native AR TAVR multicenter registry, procedural and clinical outcomes were assessed according to VARC-2 criteria and compared between early- and new-generation devices...
December 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29191025/progress-and-future-direction-of-chromosome-centric-human-proteome-project
#20
Young-Ki Paik, Christopher M Overall, Eric W Deutsch, Jennifer E Van Eyk, Gilbert S Omenn
This special issue of JPR celebrates the fifth anniversary of the Chromosome-Centric Human Proteome Project (C-HPP). We present 27 manuscripts in four categories: (i) Metrics of Progress and Resources, (ii) Missing Protein Detection and Validation, (iii) Analytical Methods and Quality Assessment, and (iv) Protein Functions and Disease. We briefly introduce key messages from each paper, mostly from C-HPP teams and some from the Biology and Disease-driven HPP. From the first few months of the C-HPP NeXt-MP50 Missing Proteins Challenge, authors report 73 missing protein detections that meet the HPP guidelines using several novel approaches...
December 1, 2017: Journal of Proteome Research
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