keyword
MENU ▼
Read by QxMD icon Read
search

E Deutsch

keyword
https://www.readbyqxmd.com/read/27879066/xxix-%C3%A2-symposium-augustanum-jahrestagung-der-deutsch-italienischen-gesellschaft-f%C3%A3-r-dermatologie-e-%C3%A2-v-in-genua-am-27-%C3%A2-mai%C3%A2-2016
#1
Claudio Feliciani, Michael Hertl, Bernd-Rüdiger Balda
No abstract text is available yet for this article.
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27871334/exploiting-members-of-the-bahd-acyltransferase-family-to-synthesize-multiple-hydroxycinnamate-and-benzoate-conjugates-in-yeast
#2
Aymerick Eudes, Maxence Mouille, David S Robinson, Veronica T Benites, George Wang, Lucien Roux, Yi-Lin Tsai, Edward E K Baidoo, Tsan-Yu Chiu, Joshua L Heazlewood, Henrik V Scheller, Aindrila Mukhopadhyay, Jay D Keasling, Samuel Deutsch, Dominique Loqué
BACKGROUND: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for the synthesis in plants of a myriad of secondary metabolites, some of which are beneficial for humans either as therapeutics or as specialty chemicals such as flavors and fragrances. The production of pharmaceutical, nutraceutical and commodity chemicals using engineered microbes is an alternative, green route to energy-intensive chemical syntheses that consume petroleum-based precursors...
November 21, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27834580/nkg2d-ligand-expression-in-pediatric-brain-tumors
#3
Kristen Haberthur, Kathryn Brennan, Virginia Hoglund, Stephanie Balcaitis, Harrison Chinn, Amira Davis, Shannon Kreuser, Conrad Winter, Sarah E S Leary, Gail H Deutsch, Richard G Ellenbogen, Courtney A Crane
Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined. In this study, we sought to determine whether the model of immune escape observed in adult brain tumors is reflected in patients with pediatric brain tumors by evaluating NKG2D ligand expression on tissue microarrays created from patients with a variety of childhood brain tumor diagnoses, and infiltration of Natural Killer and myeloid cells...
November 11, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27825187/-exposure-to-limited-resources-in-the-gastroenterology-results-of-a-survey-of-hospital-physicians
#4
L Kerkemeyer, A Reifferscheid, N Pomorin, J Wasem
Background and research question: The hospital sector is currently characterized by a high economic pressure. As well the DRG system as the investment financing by the federal states imply financial limitations. Hospitals react to this situation by trying to reduce costs and to increase case volume. It is questionable whether and to what extent patient care and the working conditions of the physicians are affected by these circumstances. Especially, gastroenterological patients were considered to be insufficiently covered by the DRG system in the past...
November 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27806233/fulminant-myocarditis-with-combination-immune-checkpoint-blockade
#5
Douglas B Johnson, Justin M Balko, Margaret L Compton, Spyridon Chalkias, Joshua Gorham, Yaomin Xu, Mellissa Hicks, Igor Puzanov, Matthew R Alexander, Tyler L Bloomer, Jason R Becker, David A Slosky, Elizabeth J Phillips, Mark A Pilkinton, Laura Craig-Owens, Nina Kola, Gregory Plautz, Daniel S Reshef, Jonathan S Deutsch, Raquel P Deering, Benjamin A Olenchock, Andrew H Lichtman, Dan M Roden, Christine E Seidman, Igor J Koralnik, Jonathan G Seidman, Robert D Hoffman, Janis M Taube, Luis A Diaz, Robert A Anders, Jeffrey A Sosman, Javid J Moslehi
Immune checkpoint inhibitors have improved clinical outcomes associated with numerous cancers, but high-grade, immune-related adverse events can occur, particularly with combination immunotherapy. We report the cases of two patients with melanoma in whom fatal myocarditis developed after treatment with ipilimumab and nivolumab. In both patients, there was development of myositis with rhabdomyolysis, early progressive and refractory cardiac electrical instability, and myocarditis with a robust presence of T-cell and macrophage infiltrates...
November 3, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27764848/stellungnahme-von-dog-und-bva-zum-einsatz-der-bildanalyse-des-sehnervenkopfes-beim-glaukom
#6
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27733489/recombinant-fetuin-b-protein-maintains-high-fertilization-rate-in-cumulus-cell-free-mouse-oocytes
#7
E Dietzel, J Floehr, E Van de Leur, R Weiskirchen, W Jahnen-Dechent
STUDY QUESTION: Does fetuin-B inhibit premature zona pellucida (ZP) hardening in mouse oocytes in vitro and thus increase IVF rate? SUMMARY ANSWER: Supplementation of oocyte in vitro maturation (IVM) media with recombinant mouse fetuin-B (rmFetuB) increased fertilization rate without affecting mouse embryo development into blastocysts. WHAT IS KNOWN ALREADY: Mice deficient in fetuin-B are infertile owing to premature ZP hardening. Premature ZP hardening also occurs during oocyte IVM leading to decreased fertilization rate...
October 12, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27733488/down-regulation-of-the-liver-derived-plasma-protein-fetuin-b-mediates-reversible-female-infertility
#8
J Floehr, E Dietzel, C Schmitz, A Chappell, W Jahnen-Dechent
STUDY QUESTION: Does antisense oligonucleotide (ASO)-mediated down-regulation of serum fetuin-B cause an infertility-like fetuin-B gene deficiency in female mice? SUMMARY ANSWER: Pharmacological fetuin-B down-regulation by ASO therapy results in reversible infertility in female mice. WHAT IS KNOWN ALREADY: Female fetuin-B deficient (Fetub(-/-)) mice are infertile owing to premature zona pellucida (ZP) hardening. Enzyme activity studies demonstrated that fetuin-B is a potent and highly specific inhibitor of the zona proteinase ovastacin, which cleaves ZP protein 2 (ZP2) and thus mediates definitive ZP hardening...
October 12, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27709261/-non-selective-primary-prevention-programs-for-childhood-overweight-an-overview
#9
Ulla Walter, Iris Pigeot
BACKGROUND: Despite an obvious stabilization the prevalence of childhood overweight and obesity is still too high. Since childhood obesity may track into adulthood and lead to major health consequences, effective primary prevention programs are of high relevance. OBJECTIVE: In recent years several universal primary prevention programs, measures or projects have been developed and evaluated in Germany. This paper gives an overview. METHODS: An internet search and a search in the archive of the Deutsche Ärzteblatt were conducted to identify universal programs in Germany from 2006 to 2015...
October 5, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27674316/rectal-balloon-use-in-intensity-modulated-radiation-therapy-planning-for-posthysterectomy-gynecological-malignancies-can-limit-rectal-dose-and-toxicity-as-well-as-limit-vaginal-displacement
#10
C C Wu, T Yanagihara, Y R Wuu, A Jani, E P Xanthopoulos, A Tiwari, I Deutsch
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27623508/immunotherapy-in-head-and-neck-cancer-harnessing-profit-on-a-system-disruption
#11
REVIEW
Chloé Rancoule, Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Yaoxiong Xia, Anis El Meddeb Hamrouni, Claire Rodriguez-Lafrasse, Cyrus Chargari, Eric Deutsch, Nicolas Magné
Immune system deregulation and evasion play a key role in cancers' evolution and progression, including squamous cell carcinoma of the head and neck (SCCHN). Development of basic research proposed a whole new vision of cancer treatment, based on a strong biological rational, and targeting intrinsic deregulations. Immunotherapies provide an encouraging strategy for patients' improved outcomes. Immune-based therapies could act on cancer growth and/or development throughout many pathways. If cetuximab is for now the only monoclonal antibody approved for SCCHN management, other strategies, e...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27614521/-radiotherapy-and-targeted-therapy-immunotherapy
#12
D Antoni, S Bockel, E Deutsch, F Mornex
Thanks to recent advances achieved in oncologic systemic and local ablative treatment, the treatments become more and more efficient in term of local control and overall survival. Thus, the targeted therapies, immunotherapy or stereotactic radiotherapy have modified the management of patients, especially in case of oligometastatic disease. Many questions are raised by these innovations, particularly the diagnosis and management of new side effects or that of the combination of these different treatments, depending on the type of primary tumor...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27581613/uncovering-novel-mobile-genetic-elements-and-their-dynamics-through-an-extra-chromosomal-sequencing-approach
#13
COMMENT
Douglas R Deutsch, Bryan Utter, Vincent A Fischetti
Staphylococcus aureus is a major clinically important pathogen with well-studied phage contributions to its virulence potential. In this commentary, we describe our method to enrich and sequence stealth extra-chromosomal DNA elements in the bacterial cell, allowing the identification of novel extra-chromosomal prophages in S. aureus clinical strains. Extra-chromosomal sequencing is a useful and broadly applicable tool to study bacterial genomics, giving a temporal glance at the extra-chromosomal compartment of the cell and allowing researchers to uncover lower-copy plasmidial elements (e...
July 2016: Mobile Genetic Elements
https://www.readbyqxmd.com/read/27578049/neutrophil-recruitment-limited-by-high-affinity-bent-%C3%AE-2-integrin-binding-ligand-in-cis
#14
Zhichao Fan, Sara McArdle, Alex Marki, Zbigniew Mikulski, Edgar Gutierrez, Britta Engelhardt, Urban Deutsch, Mark Ginsberg, Alex Groisman, Klaus Ley
Neutrophils are essential for innate immunity and inflammation and many neutrophil functions are β2 integrin-dependent. Integrins can extend (E(+)) and acquire a high-affinity conformation with an 'open' headpiece (H(+)). The canonical switchblade model of integrin activation proposes that the E(+) conformation precedes H(+), and the two are believed to be structurally linked. Here we show, using high-resolution quantitative dynamic footprinting (qDF) microscopy combined with a homogenous conformation-reporter binding assay in a microfluidic device, that a substantial fraction of β2 integrins on human neutrophils acquire an unexpected E(-)H(+) conformation...
August 31, 2016: Nature Communications
https://www.readbyqxmd.com/read/27573249/highlights-of-the-biology-and-disease-driven-human-proteome-project-2015-2016
#15
Jennifer E Van Eyk, Fernando J Corrales, Ruedi Aebersold, Ferdinando Cerciello, Eric W Deutsch, Paola Roncada, Jean-Charles Sanchez, Tadashi Yamamoto, Pengyuan Yang, Hui Zhang, Gilbert S Omenn
The Biology and Disease-driven Human Proteome Project (B/D-HPP) is aimed at supporting and enhancing the broad use of state-of-the-art proteomic methods to characterize and quantify proteins for in-depth understanding of the molecular mechanisms of biological processes and human disease. Based on a foundation of the pre-existing HUPO initiatives begun in 2002, the B/D-HPP is designed to provide standardized methods and resources for mass spectrometry and specific protein affinity reagents and facilitate accessibility of these resources to the broader life sciences research and clinical communities...
November 4, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27572951/-opinion-of-the-german-ophthalmological-society-and-the-professional-association-of-german-ophthalmologists-regarding-the-use-of-imaging-to-analyze-the-optic-nerve-head-in-glaucoma-july-2016
#16
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27569442/comparison-of-mapie-versus-map-in-patients-with-a-poor-response-to-preoperative-chemotherapy-for-newly-diagnosed-high-grade-osteosarcoma-euramos-1-an-open-label-international-randomised-controlled-trial
#17
Neyssa M Marina, Sigbjørn Smeland, Stefan S Bielack, Mark Bernstein, Gordana Jovic, Mark D Krailo, Jane M Hook, Carola Arndt, Henk van den Berg, Bernadette Brennan, Bénédicte Brichard, Ken L B Brown, Trude Butterfass-Bahloul, Gabriele Calaminus, Heike E Daldrup-Link, Mikael Eriksson, Mark C Gebhardt, Hans Gelderblom, Joachim Gerss, Robert Goldsby, Allen Goorin, Richard Gorlick, Holcombe E Grier, Juliet P Hale, Kirsten Sundby Hall, Jendrik Hardes, Douglas S Hawkins, Knut Helmke, Pancras C W Hogendoorn, Michael S Isakoff, Katherine A Janeway, Heribert Jürgens, Leo Kager, Thomas Kühne, Ching C Lau, Patrick J Leavey, Stephen L Lessnick, Leo Mascarenhas, Paul A Meyers, Hubert Mottl, Michaela Nathrath, Zsuzsanna Papai, R Lor Randall, Peter Reichardt, Marleen Renard, Akmal Ahmed Safwat, Cindy L Schwartz, Michael C G Stevens, Sandra J Strauss, Lisa Teot, Mathias Werner, Matthew R Sydes, Jeremy S Whelan
BACKGROUND: We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. METHODS: EURAMOS-1 was an open-label, international, phase 3 randomised, controlled trial. Consenting patients with newly diagnosed, resectable, high-grade osteosarcoma aged 40 years or younger were eligible for randomisation...
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27559045/mincle-signaling-promotes-con-a-hepatitis
#18
Stephanie H Greco, Alejandro Torres-Hernandez, Aleksandr Kalabin, Clint Whiteman, Rae Rokosh, Sushma Ravirala, Atsuo Ochi, Johana Gutierrez, Muhammad Atif Salyana, Vishnu R Mani, Savitha V Nagaraj, Michael Deutsch, Lena Seifert, Donnele Daley, Rocky Barilla, Mautin Hundeyin, Yuriy Nikifrov, Karla Tejada, Bruce E Gelb, Steven C Katz, George Miller
Con A hepatitis is regarded as a T cell-mediated model of acute liver injury. Mincle is a C-type lectin receptor that is critical in the immune response to mycobacteria and fungi but does not have a well-defined role in preclinical models of non-pathogen-mediated inflammation. Because Mincle can ligate the cell death ligand SAP130, we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepatitis. Acute liver injury was assessed in the murine Con A hepatitis model using C57BL/6, Mincle(-/-), and Dectin-1(-/-) mice...
October 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27558626/borrelia-mayonii-sp-nov-a-member-of-the-borrelia-burgdorferi-sensu-lato-complex-detected-in-patients-and-ticks-in-the-upper-midwestern-united-states
#19
Bobbi S Pritt, Laurel B Respicio-Kingry, Lynne M Sloan, Martin E Schriefer, Adam J Replogle, Jenna Bjork, Gongping Liu, Luke C Kingry, Paul S Mead, David F Neitzel, Elizabeth Schiffman, Diep K Hoang Johnson, Jeffrey P Davis, Susan M Paskewitz, David Boxrud, Alecia Deedon, Xia Lee, Tracy K Miller, Michelle A Feist, Christopher R Steward, Elitza S Theel, Robin Patel, Cole L Irish, Jeannine M Petersen
Lyme borreliosis (LB) is a multisystem disease caused by spirochetes in the Borrelia burgdorferi sensu lato (Bbsl) genospecies complex. We previously described a novel Borrelia species (type strain MN14-1420T) that causes LB among patients with exposures to ticks in the upper midwestern United States. Patients infected with the novel species demonstrated high levels of spirochetemia and differing clinical symptoms as compared to other Bbsl genospecies. The organism was detected from human specimens using polymerase chain reaction, microscopy, serology and culture...
August 24, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27549612/should-tissue-structure-suppress-or-amplify-selection-to-minimize-cancer-risk
#20
Laura Hindersin, Benjamin Werner, David Dingli, Arne Traulsen
BACKGROUND: It has been frequently argued that tissues evolved to suppress the accumulation of growth enhancing cancer inducing mutations. A prominent example is the hierarchical structure of tissues with high cell turnover, where a small number of tissue specific stem cells produces a large number of specialized progeny during multiple differentiation steps. Another well known mechanism is the spatial organization of stem cell populations and it is thought that this organization suppresses fitness enhancing mutations...
2016: Biology Direct
keyword
keyword
12018
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"