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https://www.readbyqxmd.com/read/28033623/-consensus-of-the-deutsche-gesellschaft-der-plastischen-rekonstruktiven-und-%C3%A3-sthetischen-chirurgen-dgpr%C3%A3-c-on-autologous-fat-grafting
#1
R E Giunta, R E Horch, L Prantl, E M Baur, C Herold, L Kamolz, M Lehnhardt, E M Noah, O Rennekampff, D Richter, D J Schaefer, K Ueberreiter
On occasion of the Munich Plastic Symposium in Munich the board of the Deutsche Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC) together with a group of experts who were also involved in the preparation of the recently published S2K guideline "Autologous Fat Grafting", prepared a consensus statement from a plastic-surgical point of view so to evaluate current spects and taking into account the current legal framework: 1. Autologous Fat Grafting is a long established treatment in plastic surgery and does not differ from other tissue grafts...
December 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28025611/evidence-and-evidence-gaps-an-introduction
#2
REVIEW
Gabriele Dreier, Jan Löhler
Background: Medical treatment requires the implementation of existing evidence in the decision making process in order to be able to find the best possible diagnostic, therapeutic or prognostic measure for the individual patient based on the physician's own expertise. Clinical trials form the evidence base and ideally, their results are assembled, analyzed, summarized, and made available in systematic review articles. Beside planning, conducting, and evaluating clinical trials in conformity with GCP (good clinical practice), it is essential that all results of conducted studies are publicly available in order to avoid publication bias...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/28024689/alk-testing-in-non-small-cell-lung-cancer-nsclc-immunohistochemistry-ihc-and-or-fluorescence-in-situ-hybridisation-fish-statement-of-the-germany-society-for-pathology-dgp-and-the-working-group-thoracic-oncology-aio-of-the-german-cancer-society-e-v-stellungnahme
#3
M von Laffert, P Schirmacher, A Warth, W Weichert, R Büttner, R M Huber, J Wolf, F Griesinger, M Dietel, Ch Grohé
The EML4-ALK pathway plays an important role in a significant subset of non-small cell lung cancer patients. Treatment options such as ALK tyrosine kinase inhibitors lead to improved progression free survival and overall survival. These therapeutic options are chosen on the basis of the identification of the underlying genetic signature of the EML-ALK translocation. Efficient and easily accessible testing tools are required to identify eligible patients in a timely fashion. While FISH techniques are commonly used to detect this translocation, the broad implementation of this type of ALK testing into routine diagnostics is not optimal due to technical, structural and financial reasons...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28007109/trypan-blue-as-a-surgical-adjunct-in-pediatric-cataract-surgery
#4
Gabrielle Fridman, Allison E Rizzuti, Jewel Liao, Mark Rolain, James A Deutsch, Stephen C Kaufman
PURPOSE: To study the effect of trypan blue on lens capsule elasticity and ease of completing a continuous curvilinear capsulorhexis (CCC) in a sheep lens model and to subsequently observe the effects of trypan blue in the surgical setting of 3 pediatric patients. SETTING: State University of New York, Downstate Medical Center, Brooklyn, New York, USA. DESIGN: Prospective case series. METHODS: Twenty-four lenses were excised from fresh sheep globes...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27943610/covalent-surface-modification-of-gaas-100-photocathodes-for-water-splitting-in-highly-acidic-electrolyte
#5
Logan E Garner, K Xerxes Steirer, James L Young, Nicholas C Anderson, Elisa M Miller, Jonathan S Tinkham, Todd G Deutsch, Alan Sellinger, John A Turner, Nathan R Neale
Efficient water splitting using light as the only energy input requires stable semiconductor electrodes with favorable energetics for the water oxidation and proton reduction reactions. Strategies to tune electrode potentials using molecular dipoles adsorbed to the semiconductor surface have been pursued for decades but are often based on weak interactions and quickly react to desorb the molecule under conditions relevant to sustained photoelectrolysis. Here, we show that covalent attachment of fluorinated, aromatic molecules to p-GaAs(100) surfaces can be employed to tune the photocurrent onset potentials of p-GaAs(100) photocathodes and reduce the external energy required for water splitting...
December 12, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27879066/xxix-%C3%A2-symposium-augustanum-jahrestagung-der-deutsch-italienischen-gesellschaft-f%C3%A3-r-dermatologie-e-%C3%A2-v-in-genua-am-27-%C3%A2-mai%C3%A2-2016
#6
Claudio Feliciani, Michael Hertl, Bernd-Rüdiger Balda
No abstract text is available yet for this article.
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27871334/exploiting-members-of-the-bahd-acyltransferase-family-to-synthesize-multiple-hydroxycinnamate-and-benzoate-conjugates-in-yeast
#7
Aymerick Eudes, Maxence Mouille, David S Robinson, Veronica T Benites, George Wang, Lucien Roux, Yi-Lin Tsai, Edward E K Baidoo, Tsan-Yu Chiu, Joshua L Heazlewood, Henrik V Scheller, Aindrila Mukhopadhyay, Jay D Keasling, Samuel Deutsch, Dominique Loqué
BACKGROUND: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for the synthesis in plants of a myriad of secondary metabolites, some of which are beneficial for humans either as therapeutics or as specialty chemicals such as flavors and fragrances. The production of pharmaceutical, nutraceutical and commodity chemicals using engineered microbes is an alternative, green route to energy-intensive chemical syntheses that consume petroleum-based precursors...
November 21, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27834580/nkg2d-ligand-expression-in-pediatric-brain-tumors
#8
Kristen Haberthur, Kathryn Brennan, Virginia Hoglund, Stephanie Balcaitis, Harrison Chinn, Amira Davis, Shannon Kreuser, Conrad Winter, Sarah E S Leary, Gail H Deutsch, Richard G Ellenbogen, Courtney A Crane
Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined. In this study, we sought to determine whether the model of immune escape observed in adult brain tumors is reflected in patients with pediatric brain tumors by evaluating NKG2D ligand expression on tissue microarrays created from patients with a variety of childhood brain tumor diagnoses, and infiltration of Natural Killer and myeloid cells...
December 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27825187/-exposure-to-limited-resources-in-the-gastroenterology-results-of-a-survey-of-hospital-physicians
#9
L Kerkemeyer, A Reifferscheid, N Pomorin, J Wasem
Background and research question: The hospital sector is currently characterized by a high economic pressure. As well the DRG system as the investment financing by the federal states imply financial limitations. Hospitals react to this situation by trying to reduce costs and to increase case volume. It is questionable whether and to what extent patient care and the working conditions of the physicians are affected by these circumstances. Especially, gastroenterological patients were considered to be insufficiently covered by the DRG system in the past...
November 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27806233/fulminant-myocarditis-with-combination-immune-checkpoint-blockade
#10
Douglas B Johnson, Justin M Balko, Margaret L Compton, Spyridon Chalkias, Joshua Gorham, Yaomin Xu, Mellissa Hicks, Igor Puzanov, Matthew R Alexander, Tyler L Bloomer, Jason R Becker, David A Slosky, Elizabeth J Phillips, Mark A Pilkinton, Laura Craig-Owens, Nina Kola, Gregory Plautz, Daniel S Reshef, Jonathan S Deutsch, Raquel P Deering, Benjamin A Olenchock, Andrew H Lichtman, Dan M Roden, Christine E Seidman, Igor J Koralnik, Jonathan G Seidman, Robert D Hoffman, Janis M Taube, Luis A Diaz, Robert A Anders, Jeffrey A Sosman, Javid J Moslehi
Immune checkpoint inhibitors have improved clinical outcomes associated with numerous cancers, but high-grade, immune-related adverse events can occur, particularly with combination immunotherapy. We report the cases of two patients with melanoma in whom fatal myocarditis developed after treatment with ipilimumab and nivolumab. In both patients, there was development of myositis with rhabdomyolysis, early progressive and refractory cardiac electrical instability, and myocarditis with a robust presence of T-cell and macrophage infiltrates...
November 3, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27764848/stellungnahme-von-dog-und-bva-zum-einsatz-der-bildanalyse-des-sehnervenkopfes-beim-glaukom
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27733489/recombinant-fetuin-b-protein-maintains-high-fertilization-rate-in-cumulus-cell-free-mouse-oocytes
#12
E Dietzel, J Floehr, E Van de Leur, R Weiskirchen, W Jahnen-Dechent
STUDY QUESTION: Does fetuin-B inhibit premature zona pellucida (ZP) hardening in mouse oocytes in vitro and thus increase IVF rate? SUMMARY ANSWER: Supplementation of oocyte in vitro maturation (IVM) media with recombinant mouse fetuin-B (rmFetuB) increased fertilization rate without affecting mouse embryo development into blastocysts. WHAT IS KNOWN ALREADY: Mice deficient in fetuin-B are infertile owing to premature ZP hardening. Premature ZP hardening also occurs during oocyte IVM leading to decreased fertilization rate...
October 12, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27733488/down-regulation-of-the-liver-derived-plasma-protein-fetuin-b-mediates-reversible-female-infertility
#13
J Floehr, E Dietzel, C Schmitz, A Chappell, W Jahnen-Dechent
STUDY QUESTION: Does antisense oligonucleotide (ASO)-mediated down-regulation of serum fetuin-B cause infertility like fetuin-B gene deficiency in female mice? SUMMARY ANSWER: Pharmacological fetuin-B down-regulation by ASO therapy results in reversible infertility in female mice. WHAT IS KNOWN ALREADY: Female fetuin-B deficient (Fetub(-/-)) mice are infertile owing to premature zona pellucida (ZP) hardening. Enzyme activity studies demonstrated that fetuin-B is a potent and highly specific inhibitor of the zona proteinase ovastacin, which cleaves ZP protein 2 (ZP2) and thus mediates definitive ZP hardening...
October 12, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27709261/-non-selective-primary-prevention-programs-for-childhood-overweight-an-overview
#14
Ulla Walter, Iris Pigeot
BACKGROUND: Despite an obvious stabilization the prevalence of childhood overweight and obesity is still too high. Since childhood obesity may track into adulthood and lead to major health consequences, effective primary prevention programs are of high relevance. OBJECTIVE: In recent years several universal primary prevention programs, measures or projects have been developed and evaluated in Germany. This paper gives an overview. METHODS: An internet search and a search in the archive of the Deutsche Ärzteblatt were conducted to identify universal programs in Germany from 2006 to 2015...
November 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27674316/rectal-balloon-use-in-intensity-modulated-radiation-therapy-planning-for-posthysterectomy-gynecological-malignancies-can-limit-rectal-dose-and-toxicity-as-well-as-limit-vaginal-displacement
#15
C C Wu, T Yanagihara, Y R Wuu, A Jani, E P Xanthopoulos, A Tiwari, I Deutsch
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27623508/immunotherapy-in-head-and-neck-cancer-harnessing-profit-on-a-system-disruption
#16
REVIEW
Chloé Rancoule, Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Yaoxiong Xia, Anis El Meddeb Hamrouni, Claire Rodriguez-Lafrasse, Cyrus Chargari, Eric Deutsch, Nicolas Magné
Immune system deregulation and evasion play a key role in cancers' evolution and progression, including squamous cell carcinoma of the head and neck (SCCHN). Development of basic research proposed a whole new vision of cancer treatment, based on a strong biological rational, and targeting intrinsic deregulations. Immunotherapies provide an encouraging strategy for patients' improved outcomes. Immune-based therapies could act on cancer growth and/or development throughout many pathways. If cetuximab is for now the only monoclonal antibody approved for SCCHN management, other strategies, e...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27614521/-radiotherapy-and-targeted-therapy-immunotherapy
#17
D Antoni, S Bockel, E Deutsch, F Mornex
Thanks to recent advances achieved in oncologic systemic and local ablative treatment, the treatments become more and more efficient in term of local control and overall survival. Thus, the targeted therapies, immunotherapy or stereotactic radiotherapy have modified the management of patients, especially in case of oligometastatic disease. Many questions are raised by these innovations, particularly the diagnosis and management of new side effects or that of the combination of these different treatments, depending on the type of primary tumor...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27581613/uncovering-novel-mobile-genetic-elements-and-their-dynamics-through-an-extra-chromosomal-sequencing-approach
#18
COMMENT
Douglas R Deutsch, Bryan Utter, Vincent A Fischetti
Staphylococcus aureus is a major clinically important pathogen with well-studied phage contributions to its virulence potential. In this commentary, we describe our method to enrich and sequence stealth extra-chromosomal DNA elements in the bacterial cell, allowing the identification of novel extra-chromosomal prophages in S. aureus clinical strains. Extra-chromosomal sequencing is a useful and broadly applicable tool to study bacterial genomics, giving a temporal glance at the extra-chromosomal compartment of the cell and allowing researchers to uncover lower-copy plasmidial elements (e...
July 2016: Mobile Genetic Elements
https://www.readbyqxmd.com/read/27578049/neutrophil-recruitment-limited-by-high-affinity-bent-%C3%AE-2-integrin-binding-ligand-in-cis
#19
Zhichao Fan, Sara McArdle, Alex Marki, Zbigniew Mikulski, Edgar Gutierrez, Britta Engelhardt, Urban Deutsch, Mark Ginsberg, Alex Groisman, Klaus Ley
Neutrophils are essential for innate immunity and inflammation and many neutrophil functions are β2 integrin-dependent. Integrins can extend (E(+)) and acquire a high-affinity conformation with an 'open' headpiece (H(+)). The canonical switchblade model of integrin activation proposes that the E(+) conformation precedes H(+), and the two are believed to be structurally linked. Here we show, using high-resolution quantitative dynamic footprinting (qDF) microscopy combined with a homogenous conformation-reporter binding assay in a microfluidic device, that a substantial fraction of β2 integrins on human neutrophils acquire an unexpected E(-)H(+) conformation...
August 31, 2016: Nature Communications
https://www.readbyqxmd.com/read/27573249/highlights-of-the-biology-and-disease-driven-human-proteome-project-2015-2016
#20
Jennifer E Van Eyk, Fernando J Corrales, Ruedi Aebersold, Ferdinando Cerciello, Eric W Deutsch, Paola Roncada, Jean-Charles Sanchez, Tadashi Yamamoto, Pengyuan Yang, Hui Zhang, Gilbert S Omenn
The Biology and Disease-driven Human Proteome Project (B/D-HPP) is aimed at supporting and enhancing the broad use of state-of-the-art proteomic methods to characterize and quantify proteins for in-depth understanding of the molecular mechanisms of biological processes and human disease. Based on a foundation of the pre-existing HUPO initiatives begun in 2002, the B/D-HPP is designed to provide standardized methods and resources for mass spectrometry and specific protein affinity reagents and facilitate accessibility of these resources to the broader life sciences research and clinical communities...
November 4, 2016: Journal of Proteome Research
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