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JOURNAL ARTICLE
Lukas Goertz, David Zopfs, Jonathan Kottlors, Lenhard Pennig, Stefan Schob, Marc Schlamann, Christoph Kabbasch
OBJECTIVE: There are few studies on flow diverters with diameters >5 mm. We present our preliminary experience with the 5.5-8 mm Derivo Embolization Device (DED) implants for the treatment of cerebral aneurysms. METHODS: A consecutive series of 26 patients (median age: 60 years) treated for 32 aneurysms in 26 procedures was retrospectively analyzed for procedural characteristics, complications, and mid-term angiographic results. RESULTS: The median aneurysm size was 10...
May 5, 2024: Interventional Neuroradiology
#2
REVIEW
Timothy G White, Brandon A Santhumayor, Justin Turpin, Kevin Shah, Daniel Toscano, Ina Teron, Thomas Link, Athos Patsalides, Henry H Woo
Flow diversion (FD) has become a mainstay treatment for large wide-necked aneurysms. Despite excellent safety and efficacy, the risk of thromboembolic complications necessitates the use of dual antiplatelet therapy (DAPT). The use of DAPT makes hemorrhagic complications of stenting carry high morbidity and mortality. Additionally, DAPT usage carries a risk of "nuisance" complications that do not directly impact intracranial circulation but need to be managed nonetheless. To circumvent this issue, the most recent generation of flow diverters have undergone surface modification with various compounds to confer blood compatibility to limit clotting and thrombosis...
October 29, 2023: Interventional Neuroradiology
#3
JOURNAL ARTICLE
Ngoc T Ngo, Fabian Flottmann, Francesco Iori, Mirko Bonfanti, Aikaterini Mandaltsi, Jens Fiehler, Maxim Bester
BACKGROUND: Evaluating the deployed length of flow diverting stents (FDs) to select the optimal device size remains a challenging, yet crucial, task in aneurysm treatment. This study reports on the accuracy of PreSize Neurovascular (Oxford Heartbeat Ltd), a visualization and simulation software for FD intervention planning, in predicting FD deployed length, and on its impact on device size selection. METHODS: Imaging data from consecutive patients treated with Derivo Embolization Device (Acandis GmbH) were collected from University Medical Center Hamburg-Eppendorf and retrospectively analyzed...
October 8, 2023: Interventional Neuroradiology
#4
JOURNAL ARTICLE
Lukas Goertz, David Zopfs, Michael Schönfeld, Charlotte Zaeske, Lenhard Pennig, Gerrit Brinker, Marc Schlamann, Christoph Kabbasch
OBJECTIVE: The development of new flow-diverting devices with antithrombotic coatings may result in an improved safety profile, particularly a reduction in ischaemic stroke rates. The aim of this study was to evaluate our initial experience with the recently introduced coated Derivo® 2heal® Embolization Device (Acandis, Pforzheim, Germany). METHODS: This is a retrospective, single-centre analysis of patients with intracranial aneurysms undergoing Derivo® 2heal® Embolization Device treatment...
August 13, 2023: Interventional Neuroradiology
#5
JOURNAL ARTICLE
Mustafa Kemal Coban, Goktug Ulku, Mustafa Caglar Sahin, Cansu Unal, Hilmi Onder Okay
AIM: We report our experience with flow diverter devices in the treatment of intracranial aneurysms and share the efficacy and clinical results of the Derivo flow diverter device in the endovascular treatment of cerebrovascular aneurysms. MATERIAL AND METHODS: This retrospective study was carried out in the Regional Training and Research Hospital between October 2015 and March 2020, after the approval of the clinical research ethics committee numbered 2020/22-211 dated 12...
August 26, 2022: Turkish Neurosurgery
#6
JOURNAL ARTICLE
Maximilian Thormann, Nele Sillis, Taina Thoma, Jens Altenbernd, Björn Berger, Andrea Cioltan, Christian Loehr, Georg Bohner, Eberhard Siebert, Hannes Nordmeyer, Anastasios Mpotsaris, Daniel Behme
BACKGROUND: Flow diverters are an increasingly used treatment option for intracranial aneurysms. A recent addition to the European market is the DERIVO®2 Embolization Device (DED2), promising improved radiopacity. We aimed to assess the safety and efficacy of the DED2 regarding angiographic and clinical outcomes in ruptured and unruptured cerebral aneurysms. METHODS: We performed a multicenter trial at six interventional centers. Data were prospectively collected and all patients treated with the DED2 were included...
December 25, 2022: Interventional Neuroradiology
#7
JOURNAL ARTICLE
Carlos Piñana, Sebastian Remollo, Joaquín Zamarro, Mariano Werner, Mariano Espinosa de Rueda, Pedro Vega, David Hernandez, Eduardo Murias, Eila Rivera, Jorge Olier, Luis San Roman, Alfredo Páez-Carpio, Manuel Requena, Sonia Aixut, Marta de Dios Lascuevas, Manuel Moreu, Santiago Rosati, Laura Ludovica Gramegna, Carlos Castaño, Alejandro Tomasello
BACKGROUND: Flow diverters have emerged in recent years as a safe and effective treatment for intracranial aneurysms, with expanding indications. The Derivo embolization device (DED) is a second-generation flow diverter with a surface finish that may reduce thrombogenicity. We report our multicenter experience evaluating its safety and efficacy. METHODS: We retrospectively analyzed all patients treated with the DED in eight centers in Spain between 2016 and 2020...
August 23, 2022: Journal of Neurointerventional Surgery
#8
JOURNAL ARTICLE
Galileu Chagas Lourenço, François Dantas, Tiago Silva E Carvalho, Róberti Uili Rodrigues Firmino, Marcelo Quesado Filgueiras Filho, Renato Tavares Tosello, Cláudio José Leão, Ronie Leo Piske, Rogério Zenóbio Darwich
BACKGROUND: Flow diversion is the first-line treatment for several types of intracranial aneurysms. We report on a large series of patients treated with the Derivo Embolization Device who underwent a 1-year angiographic control follow-up. METHODS: We performed a multicenter retrospective analysis of prospectively collected data, designed to evaluate the clinical and angiographic results of treatment of intracranial aneurysms with the Derivo Flow Diverter. The primary endpoint was complete occlusion of the aneurysm within 12 months, which was evaluated using DSA...
June 15, 2022: Journal of Neurointerventional Surgery
#9
JOURNAL ARTICLE
Marcos Raúl Latorre, Nicolas Martín Molho, María Liliana Soruco, Fernando Diaz Dilernia, Guido Sebastián Carabelli, Martín Alejandro Buttaro
Necrotizing fasciitis is a life-threatening infection. Inmediate diagnosis and treatment are essential. Acetabulum fractures are a frequent identity in older adults today, associated with low-energy trauma. The indication for surgical or conservative treatment depends on multiple factors such as the age and comorbidities of the patient, the type and location of the fracture, and the socio-economic environment. We described an unusual case of infected hematoma, secondary to a closed acetabulum fracture, which led to septic arthritis of the hip joint...
June 6, 2022: Revista de la Facultad de Ciencias Médicas
#10
JOURNAL ARTICLE
Lukas Goertz, Michael Schoenfeld, David Zopfs, Jan-Christoffer Lüers, Marc Schlamann, Christoph Kabbasch
The novel DERIVO 2heal Embolisation Device (Acandis, Pforzheim, Germany) is a flexible, fully radiopaque flow-diverter with a fibrin-based nano-coating, which is supposed to make the device inert to the coagulation cascade. We report a case of pseudoaneurysm treatment with this device under single anti-platelet therapy (SAPT). A female patient underwent endoscopic surgery for chronic rhinosinusitis. During surgery, the lateral wall of the sphenoid wall and the adjacent internal carotid artery was injured, leading to massive hemorrhage, which was treated with compression and tamponades...
June 6, 2022: Interventional Neuroradiology
#11
JOURNAL ARTICLE
Soichiro Fujimura, Alex Brehm, Hiroyuki Takao, Yuya Uchiyama, Kostadin Karagiozov, Koji Fukudome, Makoto Yamamoto, Yuichi Murayama, Marios-Nikos Psychogios
BACKGROUND AND PURPOSE: We investigated the relationship between hemodynamic characteristics and clinical outcomes for aneurysms treated by the Derivo Embolization Device (DED), a novel second-generation Flow-Diverter Stent, using computational fluid dynamics (CFD). MATERIALS AND METHODS: Data were retrospectively obtained from two centers between 2017 and 2019. During the period, 23 patients were treated for 23 aneurysms with DED. In 17 patients we were able to conduct CFD analysis as six were excluded due to pre-coiling, unsuitable arterial geometry, and complex geometric form...
December 17, 2021: World Neurosurgery
#12
JOURNAL ARTICLE
Ruben Mühl-Benninghaus, Frederik Fries, Mara Kießling, Toshiki Tomori, Stefanie Krajewski, Andreas Simgen, Sabina Bauer, Natascha Hey, Eduard Brynda, Johanka Taborska, Tomáš Riedel, Wolfgang Reith, Giorgio Cattaneo, Christoph Brochhausen
PURPOSE: Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown to reduce material thrombogenicity and promote endothelial cell proliferation in vitro. We compared the biocompatibility of coated (Derivo Heal) and non-coated (Derivo bare) FDs with DAPT in an animal model. METHODS: Derivo® bare (n = 10) and Derivo® Heal (n = 10) FD were implanted in the common carotid arteries (CCAs) of New Zealand white rabbits...
December 16, 2021: Cardiovascular and Interventional Radiology
#13
JOURNAL ARTICLE
Waleed Butt, Cha-Ney Kim, Rajesh Ramaswamy, Aubrey Smith, Paul Maliakal
BACKGROUND: The efficacy of flow diverters is dependent upon robust wall apposition in the parent artery. Usage in large caliber cerebral vessels has therefore been limited as few implants with diameters > 5 mm exist. We present our initial experience in treating cerebral aneurysms using the 5.5 mm and 6 mm diameter implants of the Derivo embolization device (DED). METHODS: Our prospectively maintained institutional database was reviewed to identify patients in whom a > 5 mm DED was implanted between November 2016 and February 2021...
June 2022: Clinical Neuroradiology
#14
JOURNAL ARTICLE
Niranjan Prakash Mahajan, Mudasir Mushtaq, Amit Bhatti, Sukalyan Purkayastha, Nitin Dange, Mathew Cherian, Vipul Gupta, Vikram Huded
PURPOSE: The treatment of aneurysms with characteristics such as complex morphology, fusiform, blister-like, wide neck, or large size has been revolutionized with the introduction of flow diverters. Though flow diverters have several advantages over coiling, they also have certain important disadvantages such as the lack of immediate protection against rupture, the risk of ischemic stroke, the need for antiplatelet therapy, and long latency for complete effect. The Derivo Embolization Device (DED) is a second-generation self-expanding device that is claimed to be less thrombogenic than conventional devices...
November 2021: Neurointervention
#15
JOURNAL ARTICLE
Batur Halitcan, Sayin Bige, Balci Sinan, Akmangit Ilkay, Daglioglu Ergun, Alagoz Fatih, Arat Anil
BACKGROUND: Serial cerebral angiographic imaging is necessary to ensure cerebral aneurysm occlusion after flow diverter placement. Time-of-flight (TOF)-magnetic resonance angiography (MRA) is used for this purpose due to its lack of radiation, contrast media and complications. The comparative diagnostic yield of TOF-MRA for different flow diverters has not been previously analyzed. PURPOSE: To evaluate the diagnostic accuracy of TOF-MRA in cerebral aneurysms treated w divertersith different flow diverters...
June 7, 2021: Journal of Cardiovascular Magnetic Resonance
#16
JOURNAL ARTICLE
Mariangela Piano, Emilio Lozupone, Annalisa Sgoifo, Nunzio P Nuzzi, Francesco Asteggiano, Guglielmo Pero, Luca Quilici, Giuseppe Iannucci, Paolo Cerini, Chiara Comelli, Simone Peschillo, Ciro Princiotta, Alessandro Pedicelli, Nicola Limbucci, Giuseppe Ganci, Guido Trasimeni, Elisa Ciceri, Giuseppe Faragò, Andrea Giorgianni, Maurizio DE Nicola, Paolo Remida, Elvis Lafe, Dikran Mardighian, Maria Ruggiero, Guido A Lazzarotti, Nicola Cavasin, Lucio Castellan, Luigi Chiumarulo, Nicola Burdi, Aldo Paolucci, Francesco Briganti, Massimiliano Natrella, Francesco P Florio, Marco Pavia, Ivan Gallesio, Giuseppe Lucente, Luigi Gozzoli, Nevia Caputo, Simone Vagnarelli, Edoardo Boccardi, Luca Valvassori
BACKGROUND: The flow-diverter devices (FDDs) safety and effectiveness have been demonstrated by large series and meta-analyses. Due to the high occlusion rates and the acceptable morbidity rates of FDDs, the indications for their use are continuously expanding. We presented our Italian multicentric experience using the second generation of DERIVO® Embolization Device (DED®; Acandis, Pforzheim, Germany) to cure cerebral aneurysms, evaluating both middle and long-term safety and efficacy of this device...
April 21, 2021: Journal of Neurosurgical Sciences
#17
JOURNAL ARTICLE
[Arsenotoxicidad aguda experimental en ratones Balb/c: marcadores orgánicos y compromiso esplénico].
Alejandra Mariel Canalis, Roberto Daniel Pérez, Gisele Evangelina Falchini, Elio Andrés Soria
Introducción. El arsénico es un tóxico ambiental ampliamente diseminado en todo el mundo. En hombres y animales, diversos órganos y tejidos son blancos de sus efectos deletéreos, entre ellos, el los del sistema inmunológico. Objetivo. Determinar la intoxicación aguda por arsénico en tejidos y células diana de ratones Balb/c in vivo. Materiales y métodos. Se aplicó una inyección intraperitoneal de 9,5 o 19 mg/kg de arsenito de sodio (NaAsO2) o un volumen equivalente de solución fisiológica como control, en ratones Balb/c con 3 por cada grupo experimental...
March 19, 2021: Biomédica: Revista del Instituto Nacional de Salud
#18
JOURNAL ARTICLE
Prasanth Velvaluri, Johannes Hensler, Fritz Wodarg, Olav Jansen, Eckhard Quandt
PURPOSE: In the interventional treatment of cerebral aneurysms, flow diverter (FD) stents have played a significant role for more than a decade. Many studies have shown good aneurysm occlusion rates and low complication profiles. However, feared complications include acute thrombotic vessel occlusion due to stenotic deformation of the FD during release, the so-called twisting. This work investigates the behavior of different stent types to causative torsion forces in a mechanical model...
January 24, 2021: Clinical Neuroradiology
#19
JOURNAL ARTICLE
Y-L Li, A Roalfe, E Y-L Chu, R Lee, A C O Tsang
BACKGROUND: Newer flow diverters are enhanced with antithrombogenic surface modifications like the Pipeline Embolization Device with Shield Technology and the Derivo Embolization Device and are purported to facilitate deployment and reduce ischemic events. PURPOSE: Our aim was to review the safety and efficacy of surface-modified flow diverters in treating patients with cerebral aneurysms. DATA SOURCES: We used Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review and meta-analysis covering 3 major data bases and gray literature between 2014 and 2019...
January 2021: AJNR. American Journal of Neuroradiology
#20
JOURNAL ARTICLE
Charlotte Zaeske, Lukas Goertz, Franziska Dorn, Bernd Turowski, Nuran Abdullayev, Marc Schlamann, Thomas Liebig, Christoph Kabbasch
No abstract text is available yet for this article.
October 17, 2020: World Neurosurgery
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