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Bastian Kraus, Lukas Goertz, Bernd Turowski, Jan Borggrefe, Marc Schlamann, Franziska Dorn, Christoph Kabbasch
BACKGROUND: The Derivo Embolization Device (DED) is a novel flow diverter stent that provides increased x-ray visibility, an improved delivery system, and potentially reduced thrombogenicity. The objective of this study was to evaluate the early safety and efficacy of the second-generation DED. METHODS: We retrospectively analyzed all patients with unruptured intracranial aneurysms (UIAs) treated with the DED between November 2015 and December 2017 in three German tertiary care centers...
May 30, 2018: Journal of Neurointerventional Surgery
Erol Akgul, Hasan Bilen Onan, Suha Akpinar, Huseyin Tugsan Balli, Erol Huseyin Aksungur
OBJECTIVE: The DERIVO embolization device (DED) is a new nitinol flow diverter stent manufactured for the treatment of intracranial aneurysms. In this study, we evaluated the safety and efficacy of the DED in the treatment of intracranial aneurysms and present the short- and midterm results. METHODS: We treated 34 aneurysms using 26 devices in 24 patients with wide-necked, mostly medium-sized, and fusiform aneurysms. Fourteen of the patients included in the study were women and the other 10 were men...
November 2016: World Neurosurgery
Andreas Simgen, Désirée Ley, Christian Roth, Giorgio Franco Maria Cattaneo, Ruben Mühl-Benninghaus, Andreas Müller, Heiko Körner, Yoo-Jin Kim, Bruno Scheller, Wolfgang Reith, Umut Yilmaz
INTRODUCTION: Flow diverters are increasingly being used to treat intracranial aneurysms. This study evaluates occurring complications of flow-diverting devices in the treatment of experimental aneurysms, involving the use of micro-CT and small animal MRI at 9.4 T, in correlation to angiographic and histological findings. METHODS: We previously published two preclinical studies, in which we assessed two different flow diverters in the treatment of elastase-induced aneurysms...
October 2016: Neuroradiology
D Ley, R Mühl-Benninghaus, U Yilmaz, H Körner, G F M Cattaneo, W Mailänder, Y-J Kim, B Scheller, W Reith, A Simgen
PURPOSE: In recent years, flow diverters have provided a promising alternative to treat complex intracranial aneurysms. In this study, we compare a second-generation flow-diverting device (Derivo Embolization Device) with its prototype flow diverter, in the treatment of elastase-induced aneurysms in New Zealand white rabbits. METHODS: The Derivo Embolization Device is a self-expanding stent consisting of 48 nitinol wires. The device was implanted across the necks of 17 elastase-induced aneurysms in New Zealand white rabbits...
September 2017: Clinical Neuroradiology
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