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increased d dimer level

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https://www.readbyqxmd.com/read/29046071/clinical-significance-of-the-serotonin-release-assay-and-platelet-count-monitoring-after-cardiac-surgery
#1
Shinya Motohashi, Takefumi Matsuo, Hidenori Inoue, Makoto Kaneko, Shunya Shindo
Heparin-induced thrombocytopenia (HIT) is one of the serious complications in patients who undergo cardiac surgery. However, there remains a major problem in diagnosing HIT because the current immunological assays for detection of HIT antibody have limitations. Furthermore, the clinical course of thrombocytopenia in this surgery makes it increasingly difficult to diagnose HIT. We investigated the relationship between platelet count and HIT antibody in 59 patients who underwent cardiac surgery using cardiopulmonary bypass (CPB)...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29024233/use-of-d-dimer-measurement-to-guide-anticoagulant-treatment-in-recurrent-pregnancy-loss-associated-with-antiphospholipid-syndrome
#2
Shi Hua Bao, Shi Le Sheng, Hong Liao, Qian Zhou, Sophia Twum Frempong, Wei Yan Tu
PROBLEM: To examine whether the level of plasma D-dimer can guide anticoagulant treatment in recurrent pregnancy loss (RPL) associated with antiphospholipid syndrome (APS). METHODS: A total of 1096 RPL women with APS between 2012 and 2015 in a single-center hospital were randomly divided into two groups (group A, 75 mg of low-dose aspirin [LDA] daily; group B, 75 mg of LDA plus 4100 U of low molecular weight heparin [LMWH] subcutaneously daily); 1015 of the total successfully completed the trial...
October 11, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29019082/loss-of-the-nutrient-sensor-tas1r3-leads-to-reduced-bone-resorption
#3
Michael S Eaton, Nicholas Weinstein, Jordan B Newby, Maggie M Plattes, Hanna E Foster, Jon W Arthur, Taylor D Ward, Stephen R Shively, Ryann Shor, Justin Nathan, Hannah M Davis, Lilian I Plotkin, Eric M Wauson, Brian J Dewar, Aaron Broege, Jonathan W Lowery
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively. It was recently reported that deletion of TAS1R3 expression in Tas1R3 mutant mice leads to increased cortical bone mass but the underlying cellular mechanism leading to this phenotype remains unclear...
October 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29017215/-pulmonary-embolism-despite-rivaroxaban-in-an-obese-patient
#4
Thomas Schuh, Claudia Stöllberger
Introduction Rivaroxaban, an oral factor Xa inhibitor, is approved for therapy of venous thromboembolism. It is unclear whether the standard dose for patients with a body mass index (BMI) > 40 kg/m(2) is sufficient. History The 45-year-old patient was admitted because of increasing respiratory distress. She had a history of pulmonary embolism 30 months before the admission, a factor V Leiden mutation and several hospitalisations due to dermatomycoses. The patient briefly took phenprocoumon which was changed to 20 mg rivaroxaban due to a lack of adherence...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28991883/inflammation-related-morbidity-and-mortality-among-hiv-positive-adults-how-extensive-is-it
#5
Brian B Hart, Anna D Nordell, Jason F Okulicz, Adrian Palfreeman, Andrzej Horban, Eynat Kedem, Jacqueline Neuhaus, David R Jacobs, Daniel A Duprez, James D Neaton
OBJECTIVE: To determine the rate of grade 4, potentially life-threatening, events not attributable to AIDS, cardiovascular disease (CVD) or non-AIDS cancer among participants on antiretroviral therapy (ART), and to describe associations of these events with interleukin-6 and D-dimer. DESIGN: Cohort study. METHODS: HIV-infected participants on ART (N=3,568) with an HIV RNA level ≤ 500 copies/mL were followed for grade 4, AIDS, CVD, non-AIDS cancer and all-cause mortality events...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28990745/diagnostic-value-of-circulating-microrna-27a-b-in-patients-with-acute-pulmonary-embolism
#6
Qian Wang, Junfen Ma, Zhiyun Jiang, Fan Wu, Jiedan Ping, Liang Ming
BACKGROUND: Circulating microRNAs (miRNAs) have been increasingly suggested as biomarkers for numerous diseases. The aims of this study were to evaluate the expression of plasma miR-27a/b in patients with acute pulmonary embolism (APE) and determine the possibility of miR-27a/b as diagnostic biomarkers for APE. METHODS: 78 APE patients diagnosed by computed tomographic pulmonary angiography (CTPA) and 70 age and gender matched normal volunteers were included in this study...
October 9, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28986001/a-bioprosthetic-total-artificial-heart-for-end-stage-heart-failure-results-from-a-pilot-study
#7
Christian Latrémouille, Alain Carpentier, Pascal Leprince, Jean-Christian Roussel, Bernard Cholley, Elodie Boissier, Eric Epailly, Antoine Capel, Piet Jansen, David M Smadja
BACKGROUND: The electro-hydraulically actuated Carmat total artificial heart (C-TAH) is designed to replace the heart in patients with end-stage heart failure, either as bridge to transplant or destination therapy. It provides pulsatile flow and contains bio-prosthetic blood contacting materials. A clinical feasibility study was conducted to evaluate the C-TAH safety and performance. METHODS: Hospitalized patients, at imminent risk of death from irreversible biventricular failure despite optimal medical management, and not eligible for transplant or eligible but on extracorporeal life support, were enrolled...
September 14, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28974399/perioperative-comparison-of-blood-loss-and-complications-between-simultaneous-bilateral-and-unilateral-total-knee-arthroplasty-for-knee-osteoarthritis
#8
Yongjian Qi, Kai Tie, Hua Wang, Zhengqi Pan, Xinyu Zhao, Heqiang Chen, Liaobin Chen
OBJECTIVE: This study aimed to compare the blood loss and complications between simultaneous bilateral total knee arthroplasty (SBTKA) and unilateral total knee arthroplasty (UTKA). METHODS: This study included 54 SBTKAs and 70 UTKAs performed between 2013 and 2014. Groups were compared with respect to blood loss, hemoglobin, hematocrit, D-dimer, blood transfusion, and complications. RESULTS: Hemoglobin between the groups was not significantly different (P>0...
September 30, 2017: Knee
https://www.readbyqxmd.com/read/28969137/haemostatic-profile-of-patients-with-chronic-liver-disease-its-correlation-with-severity-and-outcome
#9
Varnika Rai, Neeraj Dhameja, Sandip Kumar, Jyoti Shukla, Rajeev Singh, Vinod Kumar Dixit
INTRODUCTION: The liver plays an important role in the haemostatic system as it synthesizes the majority of coagulation factors and fibrinolytic proteins. AIM: The present study was planned to determine the range of haemostatic defects in patients of chronic liver diseases. MATERIALS AND METHODS: Test performed included Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), Thrombin Time (TT), Fibrinogen, Protein C, D Dimer and platelet count...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28968428/evaluation-of-hemostasis-parameters-and-the-role-of-the-oxidative-damage-to-plasma-proteins-in-the-modulation-of-hemostasis-in-patients-with-nephrolithiasis-before-and-after-extracorporeal-shock-wave-lithotripsy
#10
Paweł Woźniak, Bogdan Kontek, Waldemar Różański, Beata Olas
PURPOSE: Extracorporeal shock wave lithotripsy (ESWL) is a commonly-used method in urology, which may modulate hemostasis and may induce lipid peroxidation in patients with nephrolithiasis. However, previous studies only examine changes occurring in patients 30-240 min after ESWL. The main aim of the present study was to determine whether oxidative stress may modulate the hemostatic activity of plasma in patients with nephrolithiasis before ESWL and the day after treatment ESWL. This will be performed by measuring selected parameters of hemostasis in these patients, both before ESWL and the following day, and assessing the level of oxidative damage to plasma proteins in these patients by measuring two biomarkers...
2017: PloS One
https://www.readbyqxmd.com/read/28968301/diminished-coagulation-capacity-assessed-by-calibrated-automated-thrombography-during-acute-puumala-hantavirus-infection
#11
Sirpa M Koskela, Lotta Joutsi-Korhonen, Satu M Mäkelä, Heini Huhtala, Antti I Vaheri, Ilkka Pörsti, Jukka T Mustonen, Outi K Laine
: Coagulation abnormalities are associated with Puumala-virus-induced hemorrhagic fever with renal syndrome (PUUV-HFRS). We evaluated the coagulation capacity of plasma during acute PUUV-HFRS by measuring thrombin generation using calibrated automated thrombography (CAT). The study cohort comprised 27 prospectively collected, consecutive, hospital-treated patients with acute PUUV infection. Blood samples were drawn in the acute phase and at the control visit approximately 5 weeks later. To evaluate thrombin generation, the lag time of initiation, endogenous thrombin potential (ETP), and peak and time to peak thrombin concentration were assessed by CAT in platelet poor plasma without corn trypsin inhibitor...
September 28, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28962529/editor-s-highlight-pulmonary-vascular-thrombosis-in-rats-exposed-to-inhaled-sulfur-mustard
#12
Matthew D McGraw, Christopher M Osborne, Emily J Mastej, Jorge A Di Paola, Dana R Anderson, Wesley W Holmes, Danielle C Paradiso, Rhonda B Garlick, Tara B Hendry-Hofer, Raymond C Rancourt, Russell W Smith, Carol Burns, Gates B Roe, Jacqueline S Rioux, Carl W White, Livia A Veress
Sulfur mustard (SM) is a chemical warfare agent. When inhaled, SM causes significant injury to the respiratory tract. Although the mechanism involved in acute airway injury after SM inhalation has been well described previously, the mechanism of SM's contribution to distal lung vascular injury is not well understood. We hypothesized that acute inhalation of vaporized SM causes activated systemic coagulation with subsequent pulmonary vascular thrombi formation after SM inhalation exposure. Sprague Dawley rats inhaled SM ethanolic vapor (3...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28950757/better-platelet-function-less-fibrinolysis-and-less-hemolysis-in-re-transfused-residual-pump-blood-with-the-ringer-s-chase-technique-a-randomized-pilot-study
#13
Anki Olsson, Joakim Alfredsson, Sofia Ramström, Rolf Svedjeholm, Dermot Kenny, Eric Håkansson, Johan Sanmartin Berglund, Sören Berg
INTRODUCTION: Residual pump blood from the cardiopulmonary bypass (CPB) circuit is often collected into an infusion bag (IB) and re-transfused. An alternative is to chase the residual blood into the circulation through the arterial cannula with Ringer's acetate. Our aim was to assess possible differences in hemostatic blood quality between these two techniques. METHODS: Forty adult patients undergoing elective coronary artery bypass graft surgery with CPB were randomized to receive the residual pump blood by either an IB or through the Ringer's chase (RC) technique...
September 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28940056/causes-and-prognostic-factors-for-early-death-in-patients-with-acute-promyelocytic-leukemia-treated-with-single-agent-arsenic-trioxide
#14
Jinxiao Hou, Shuye Wang, Yingmei Zhang, Dachuan Fan, Haitao Li, Yiju Yang, Fei Ge, Wenyi Hou, Jinyue Fu, Ping Wang, Hongli Zhao, Jiayue Sun, Kunpeng Yang, Jin Zhou, Xiaoxia Li
Early death (ED) is one of the most critical issues involved in the current care of patients with acute promyelocytic leukemia (APL). Factors identified as independent predictors of ED varied among published studies. We retrospectively analyzed the incidence, causes, and prognostic factors of ED in a series of 216 patients with newly diagnosed APL who received arsenic trioxide (ATO) as induction therapy. Multivariate logistic regression analysis was used to determine the association of clinical factors with overall ED, hemorrhagic ED, death within 7 days, and death within 8-30 days...
September 22, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28939813/local-order-and-vibrational-coupling-of-the-c-o-stretching-mode-of-%C3%AE-caprolactone-in-liquid-binary-mixtures
#15
Wenwen Xu, Yanfang Sun, Xiaoping Dong, Si Li, Huigang Wang, Jiadan Xue, Xuming Zheng
The isotropic and anisotropic parts Raman spectra of γ-Caprolactone in the binary mixture at different concentrations have been measured. The non-coincidence effect (NCE) of γ-Caprolactone was determined in carbon tetrachloride solution and DMSO solution. The NCE of the ν11(C=O) stretching mode in the γ-Caprolactone/DMSO mixtures exhibits a linear plot, in contrast to that in the γ-Caprolactone/CCl4 mixtures, which shows an upward (convex) curvature. The reduction and enhancement of the dimer structure (short-range orientational order) of γ-Caprolactone in the γ-Caprolactone/DMSO and γ-Caprolactone/CCl4 mixtures respectively may play a major role in shifting of peak frequencies, thus the geometries of monomer and dimer of γ-Caprolactone were calculated at the B3LYP-D3/6-311 G (d,p) level of theory...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930589/procoagulant-activity-during-viral-infections
#16
Saravanan Subramaniam, Inge Scharrer
The abundance of evidence suggest that inflammation of immune and non-immune cells may lead to an imbalance of the pro- and anti-coagulant state during viral infections. During systemic infections, the endothelium plays a critical role in regulating hemostasis, and severe imbalances of endothelial function and activation can contribute to organ failure. Viral infections may elevate plasma levels of procoagulant markers such as TAT and D-dimer TF-positive MPs as well as von Willebrand factor (vWF). Although multiple clinical studies are showing the association of viral infection and increased prothrombotic risk, the pathological mechanisms have not been fully identified for most viral infections...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28928048/edoxaban-is-effective-in-reducing-the-incidence-of-asymptomatic-phlebographic-events-following-closed-wedge-high-tibial-osteotomy
#17
Hideo Kobayashi, Yasushi Akamatsu, Ken Kumagai, Yoshihiro Kusayama, Hiroyuki Okuyama, Kunihito Hirotomi, Kentaro Shinohara, Tomoyuki Saito
INTRODUCTION: The purpose of this study was twofold:1) to investigate whether edoxaban significantly decreases the rate of venous thromboembolism (VTE) following closed-wedge high tibial osteotomy (CWHTO), in terms of phlebographic event, and 2) to determine whether edoxaban is safe or increases the rate of hemorrhagic complications.We hypothesized that edoxaban would decrease the incidence of VTE and would not increase the rate of hemorrhagic complications. MATERIALS AND METHODS: We randomly enrolled 60 patients undergoing CWHTO...
September 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28912365/d-dimer-in-african-americans-whole-genome-sequence-analysis-and-relationship-to-cardiovascular-disease-risk-in-the-jackson-heart-study
#18
Laura M Raffield, Neil A Zakai, Qing Duan, Cecelia Laurie, Joshua D Smith, Marguerite R Irvin, Margaret F Doyle, Rakhi P Naik, Ci Song, Ani W Manichaikul, Yongmei Liu, Peter Durda, Jerome I Rotter, Nancy S Jenny, Stephen S Rich, James G Wilson, Andrew D Johnson, Adolfo Correa, Yun Li, Deborah A Nickerson, Kenneth Rice, Ethan M Lange, Mary Cushman, Leslie A Lange, Alex P Reiner
OBJECTIVE: Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men. Among AAs, little is known of the genetic architecture of D-dimer or the relationship of D-dimer to incident cardiovascular disease. APPROACH AND RESULTS: We measured baseline D-dimer in 4163 AAs aged 21 to 93 years from the prospective JHS (Jackson Heart Study) cohort and assessed association with incident cardiovascular disease events...
September 14, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28903520/hepatic-renal-hematologic-and-inflammatory-markers-in-hiv-infected-children-on-long-term-suppressive-antiretroviral-therapy
#19
Ann J Melvin, Meredith Warshaw, Alexandra Compagnucci, Yacine Saidi, Linda Harrison, Anna Turkova, Gareth Tudor-Williams
Background: Data on long-term toxicity of antiretroviral therapy (ART) in HIV-infected children are sparse. PENPACT-1 was an open-label trial in which HIV-infected children were assigned randomly to receive protease inhibitor (PI)- or nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based ART. Methods: We examined changes in clinical, immunologic, and inflammatory markers from baseline to year 4 in the subset of children in the PENPACT-1 study who experienced viral suppression between week 24 and year 4 of ART...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28880867/oral-tetrahydrouridine-and-decitabine-for-non-cytotoxic-epigenetic-gene-regulation-in-sickle-cell-disease-a-randomized-phase-1-study
#20
RANDOMIZED CONTROLLED TRIAL
Robert Molokie, Donald Lavelle, Michel Gowhari, Michael Pacini, Lani Krauz, Johara Hassan, Vinzon Ibanez, Maria A Ruiz, Kwok Peng Ng, Philip Woost, Tomas Radivoyevitch, Daisy Pacelli, Sherry Fada, Matthew Rump, Matthew Hsieh, John F Tisdale, James Jacobberger, Mitch Phelps, James Douglas Engel, Santhosh Saraf, Lewis L Hsu, Victor Gordeuk, Joseph DeSimone, Yogen Saunthararajah
BACKGROUND: Sickle cell disease (SCD), a congenital hemolytic anemia that exacts terrible global morbidity and mortality, is driven by polymerization of mutated sickle hemoglobin (HbS) in red blood cells (RBCs). Fetal hemoglobin (HbF) interferes with this polymerization, but HbF is epigenetically silenced from infancy onward by DNA methyltransferase 1 (DNMT1). METHODS AND FINDINGS: To pharmacologically re-induce HbF by DNMT1 inhibition, this first-in-human clinical trial (NCT01685515) combined 2 small molecules-decitabine to deplete DNMT1 and tetrahydrouridine (THU) to inhibit cytidine deaminase (CDA), the enzyme that otherwise rapidly deaminates/inactivates decitabine, severely limiting its half-life, tissue distribution, and oral bioavailability...
September 2017: PLoS Medicine
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