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increased d dimer level

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https://www.readbyqxmd.com/read/29664836/teg-lysis-shutdown-represents-coagulopathy-in-bleeding-trauma-patients-analysis-of-the-proppr-cohort
#1
Jessica C Cardenas, Charles E Wade, Bryan A Cotton, Mitchell J George, John B Holcomb, Martin A Schreiber, Nathan J White
BACKGROUND: Thrombelastography (TEG) fibrinolysis shutdown after trauma is associated with increased mortality due to hypercoagulability-associated organ failure. However, a lack of mechanistic data has precluded the development of novel interventions to treat shutdown. OBJECTIVES: To define the pathophysiology of TEG shutdown in severely injured, bleeding patients through secondary analysis of the PROPPR trial. METHODS: Fibrinolysis was characterized in PROPPR subjects using admission TEG lysis at 30 minutes (LY30) or plasmin-antiplasmin (PAP) levels...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#2
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29622877/prolonged-hemocoagulase-agkistrodon-halys-pallas-administration-induces-hypofibrinogenemia-in-patients-with-hematological-disorders-a-clinical-analysis-of-11-patients
#3
Xu Linglong, Wu Dijiong
Hemocoagulase Agkistrodon Halys Pallas, a well-established hemostatic agent used in China, has widespread applications in various conditions of bleeding and hemorrhages. Although it presents a low risk of vascular thrombosis, the agent can be easily tolerated and does not show any harmful effects, except allergy. However, long-term use of hemocoagulase may induce hypofibrinogenemia in some patients. Herein, we report 11 patients of prolonged administration of hemocoagulase Agkistrodon, with particular attention to the dynamic changes in their coagulation functions...
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29621633/molecular-characterization-of-kappa-class-glutathione-s-transferase-from-the-disk-abalone-haliotis-discus-discus-and-changes-in-expression-following-immune-and-stress-challenges
#4
W M Gayashani Sandamalika, Thanthrige Thiunuwan Priyathilaka, D S Liyanage, Sukkyoung Lee, Han-Kyu Lim, Jehee Lee
Glutathione S-transferase (GST; EC 2.5.1.18) isoenzymes represent a complex group of proteins that are involved in phase II detoxification in several organisms. In this study, GST kappa (GSTκ) from the disk abalone (Haliotis discus discus; AbGSTκ) was characterized at both the transcriptional and functional levels to determine its potential capacity to perform as a detoxification agent under conditions of different stress. The predicted AbGSTκ protein consists of 227 amino acids, with a predicted molecular weight of 25...
April 2, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29615435/association-of-biomarker-clusters-with-cardiac-phenotypes-and-mortality-in-patients-with-hiv-infection
#5
Rebecca Scherzer, Sanjiv J Shah, Eric Secemsky, Javed Butler, Carl Grunfeld, Michael G Shlipak, Priscilla Y Hsue
BACKGROUND: Although individual cardiac biomarkers are associated with heart failure risk and all-cause mortality in HIV-infected individuals, their combined use for prediction has not been well studied. METHODS AND RESULTS: Unsupervised k-means cluster analysis was performed blinded to the study outcomes in 332 HIV-infected participants on 8 biomarkers: ST2, NT-proBNP (N-terminal pro-B-type natriuretic peptide), hsCRP (high-sensitivity C-reactive protein), GDF-15 (growth differentiation factor 15), cystatin C, IL-6 (interleukin-6), D-dimer, and troponin...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29614518/hypobaric-hypoxia-causes-elevated-thrombin-generation-mediated-by-fviii-that-is-balanced-by-decreased-platelet-activation
#6
Cécile H Kicken, Marisa Ninivaggi, Joke Konings, Martijn Moorlag, Dana Huskens, Jasper A Remijn, Saartje Bloemen, Marcus D Lancé, Bas De Laat
INTRODUCTION:  Epidemiological studies suggest that hypobaric hypoxia at high altitude poses a risk for developing venous thromboembolism. The cause of this observed hypercoagulability remains unclear. Therefore, this study aimed to investigate the effect of hypobaric hypoxia at 3,883 m above sea level on thrombin generation and platelet activation. METHODS:  After complying with medical ethical procedures, 18 participants were recruited, of whom 1 had to leave the study prematurely due to mild acute mountain sickness...
April 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29577324/transfusion-of-autologous-extracellular-vesicles-from-stored-red-blood-cells-does-not-affect-coagulation-in-a-model-of-human-endotoxemia
#7
Anna L Peters, Alexander P J Vlaar, Robin van Bruggen, Dirk de Korte, Joost C M Meijers, Rienk Nieuwland, Nicole P Juffermans
BACKGROUND: Red blood cell (RBC) transfusion has been related to thromboembolic events. Microvesicles in the RBC product may support coagulation because they have procoagulant effects in vitro. We investigated whether transfusion of RBCs containing extracellular vesicles promotes coagulation in human recipients. As transfusion is mostly administered to ill patients, we used a model of endotoxemia. STUDY DESIGN AND METHODS: Eighteen healthy volunteers were randomized to receive either saline or fresh (2 days stored) or stored autologous (35 days stored) RBC transfusion (Dutch Trial Register: NTR4455)...
March 25, 2018: Transfusion
https://www.readbyqxmd.com/read/29574651/d-dimer-predicts-postoperative-recurrence-and-prognosis-in-patients-with-liver-metastasis-of-colorectal-cancer
#8
Akira Watanabe, Kenichiro Araki, Norihumi Harimoto, Norio Kubo, Takamichi Igarashi, Norihiro Ishii, Takahiro Yamanaka, Kei Hagiwara, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Colorectal cancer is common, and its incidence is increasing throughout the world. The liver is a major metastatic site, and colorectal liver metastasis (CRLM) has a poor prognosis. Although liver resection is the most effective therapy for CRLM, postoperative recurrence is common. Thus, prognostic markers for CRLM are greatly needed. D-dimer, a fibrin cleavage product, has been shown to be related to colorectal tumor progression, and is also associated with malignant progression and recurrence in various cancers...
March 24, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29571495/impact-of-roasting-on-the-flavan-3-ol-composition-sensory-related-chemistry-and-in-vitro-pancreatic-lipase-inhibitory-activity-of-cocoa-beans
#9
Todd H Stanley, Charlene B Van Buiten, Scott A Baker, Ryan J Elias, Ramaswamy C Anantheswaran, Joshua D Lambert
Roasting is an important cocoa processing step, but has been reported to reduce the polyphenol content in the beans. We investigated the impact of whole-bean roasting on the polyphenol content, aroma-related chemistry, and in vitro pancreatic lipase (PL) inhibitory activity of cocoa under a range of roasting conditions. Total phenolics, (-)-epicatechin, and proanthocyanidin (PAC) dimer - pentamer content was reduced by roasting. By contrast, roasting at 150 °C or greater increased the levels of catechin and PAC hexamers and heptamers...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29570480/evaluation-of-d-dimer-levels-in-patients-with-prosthetic-valve-thrombosis-relationship-with-thrombus-burden-and-cerebrovascular-events
#10
Sinan Cerşit, Sabahattin Gündüz, Emrah Bayam, Ahmet Güner, Semih Kalkan, Macit Kalçık, Süleyman Karakoyun, Mustafa Ozan Gürsoy, Mahmut Yesin, Özkan Candan, Mehmet Özkan
: Plasma D-dimer level is an indicator of thrombosis and endogenous fibrinolytic activity. We investigated the association between the D-dimer levels and thrombus burden and cerebrovascular events in patients with obstructive prosthetic valve thrombosis (PVT). This retrospective study included 47 patients with obstructive left-sided PVT and 32 controls in whom PVT was excluded with comprehensive transthoracic and transesophageal echocardiography (TEE). The patient group included 11 aortic, 27 mitral, and 9 aortic and mitral valve PVT patients and the control group included 2 aortic, 25 mitral, and 5 aortic and mitral valve patients...
March 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29568426/towards-quantifying-the-role-of-hydrogen-bonding-within-amphiphile-self-association-and-resultant-aggregate-formation
#11
L J White, N J Wells, L R Blackholly, H J Shepherd, B Wilson, G P Bustone, T J Runacres, J R Hiscock
Herein, we present a series of five tetrabutylammonium (TBA) sulfonate-urea amphiphilic salts. In solution these amphiphilic salts have been shown to form a variety of self-associated species. The proportion and type of which are both solvent and concentration dependent. In DMSO- d 6 a variety of NMR experiments provide evidence towards the formation of mainly dimeric over larger aggregate species. Increasing the percentage of water was shown to increase the concentration of the larger aggregates over dimers in solution...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29555628/preclinical-profile-of-ab-423-an-inhibitor-of-hepatitis-b-virus-pgrna-encapsidation
#12
Nagraj Mani, Andrew G Cole, Janet R Phelps, Andrzej Ardzinski, Kyle D Cobarrubias, Andrea Cuconati, Bruce D Dorsey, Ellen Evangelista, Kristi Fan, Fang Guo, Haitao Guo, Ju-Tao Guo, Troy O Harasym, Salam Kadhim, Steven G Kultgen, Amy C H Lee, Alice H L Li, Quanxin Long, Sara A Majeski, Richeng Mao, Kevin D McClintock, Stephen P Reid, Rene Rijnbrand, Nicholas M Snead, Holly M Micolochick Steuer, Kim Stever, Sunny Tang, Xiaohe Wang, Qiong Zhao, Michael J Sofia
AB-423 is a sulfamoylbenzamide (SBA) class of HBV capsid inhibitor in Phase 1 clinical trials. In cell culture models AB-423 showed potent inhibition of HBV replication (EC50 /EC90 = 0.08-0.27 μM/0.33-1.32 μM) with no significant cytotoxicity (CC50 >10 μM). Addition of 40% human serum resulted in a 5-fold increase in the EC50 values. AB-423 inhibited HBV genotypes A through D and nucleos/tide-resistant variants in vitro Treatment of HepDES19 cells with AB-423 resulted in capsid particles devoid of encapsidated pgRNA and rcDNA indicating it is a class II capsid inhibitor...
March 19, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29555322/increased-interleukin-11-levels-in-thoracic-aorta-and-plasma-from-patients-with-acute-thoracic-aortic-dissection
#13
Yao Xu, Jing Ye, Menglong Wang, Yuan Wang, Qingwei Ji, Ying Huang, Tao Zeng, Zhen Wang, Di Ye, Huimin Jiang, Jianfang Liu, Yingzhong Lin, Jun Wan
BACKGROUND: Interleukin (IL) 11 is closely related to tumor and hematological system diseases. Recent studies have demonstrated that IL-11 also participates in cardiovascular diseases, including ischemia-reperfusion mediated heart injury and acute myocardial infarction. This study aimed to investigate whether IL-11 is involved in acute thoracic aortic dissection (TAD). METHODS: Aortic tissue samples from normal donors and acute TAD patients were collected, and the expression of IL-11 in all aortic tissue was analyzed...
March 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29552952/analysis-of-haemostasis-biomarkers-in-patients-with-advanced-stage-lung-cancer-during-hypofractionated-radiotherapy-treatment
#14
Edyta Wolny-Rokicka, Katarzyna Brzeźniakiewicz-Janus, Jerzy Wydmański, Andrzej Tukiendorf, Agnieszka Zembroń-Łacny
Objective To investigate the relationship between changes in inflammatory and coagulatory biomarkers before and after short palliative radiotherapy in patients with advanced stage lung cancer. Methods This prospective observational single-centre study enrolled patients with histologically- or cytologically-confirmed lung cancer who were eligible for palliative radiotherapy. Inflammatory and coagulatory biomarkers including complete blood count, D-dimer and fibrinogen levels were evaluated before and after short hypofractionated radiotherapy...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29552913/clinical-investigation-of-coagulation-markers-for-early-detection-of-sepsis-induced-disseminated-intravascular-coagulation-a-single-center-prospective-observational-study
#15
Takamitsu Masuda, Tomohisa Shoko, Yoshizumi Deguchi
Disseminated intravascular coagulation (DIC) often complicates sepsis, and its early treatment is crucial for improving patient outcomes. Coagulation markers may enable earlier diagnosis of DIC. The purpose of this study was to evaluate whether the risk of DIC onset can be predicted using coagulation markers. Patients who showed symptoms of systemic inflammatory response syndrome ≥2 and the quick Sequential Organ Failure Assessment score ≥2 points were investigated. All blood samples collected from the time of hospital admission to 7 days postadmission were investigated...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29552106/efficacy-of-thoracoscopic-surgery-in-the-treatment-of-lung-cancer-in-the-perioperative-period-and-its-effects-on-serum-d-dimer
#16
Yuanshan Yao, Haibo Shen, Yinjie Zhou, Zhenhua Yang, Hongbo Huang
The aim of this study was to investigate the feasibility and safety of thoracoscopic surgery in the treatment of lung cancer and its effect on serum D-dimer. A total of 218 patients with lung cancer treated in the Department of Thoracic Surgery of Ningbo No. 2 Hospital from January 1, 2013 to December 31, 2016, were retrospectively analyzed. Of the 218 patients, 120 patients underwent thoracotomy (thoracotomy group) and 98 patients underwent thoracoscopic surgery (thoracoscopy group). The clinical efficacy in the perioperative period and serum D-dimer level were compared between the two groups...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29551487/left-atrial-function-inflammation-and-prothrombotic-response-after-radiofrequency-ablation-for-atrial-fibrillation
#17
Guangli Yin, Ruiqin Xie, Ling You, Hongning Yin, Yucui Sun, Jinglan Wu, Yansha Zhao, Xue Geng, Yanan Zhang
BACKGROUND: The conversion of atrial fibrillation (AF) to sinus rhythm is associated with transient dysfunction of the left atrium (LA). This study aimed to investigate the time course of LA function and inflammation after radiofrequency (RF) ablation for paroxysmal AF. METHODS: Fifty-three patients with paroxysmal AF undergoing RF ablation were recruited. White blood cells were counted and high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and D-dimer levels were measured...
March 15, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29538006/tissue-type-plasminogen-activator-transgenic-rats-for-evaluating-inhibitors-of-the-activated-form-of-thrombin-activatable-fibrinolysis-inhibitor
#18
Yusuke Ito, Kengo Noguchi, Yoshiyuki Morishima, Kyoji Yamaguchi
: No rodent models are currently available for evaluating inhibitors of the activated form of thrombin-activatable fibrinolysis inhibitor (TAFIa) without exogenous supplementation of tissue-type plasminogen activator (tPA). Characterization of tPA transgenic rats as a tool for the nonclinical evaluation of TAFIa inhibitors is the objective of the current study. tPA transgenic rats were subjected to rat models of tissue-factor-induced thromboembolism, FeCl3-induced deep vein thrombosis (DVT) and arterial thrombosis, and tail bleeding...
March 13, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29512362/long-haul-flights-edema-and-thrombotic-events-prevention-with-stockings-and-pycnogenol%C3%A2-supplementation-lonflit-registry-study
#19
Gianni Belcaro, Umberto Cornelli, Mark Dugall, Morio Hosoi, Roberto Cotellese, Beatrice Feragalli
BACKGROUND: This registry study evaluated the effects of Pycnogenol® on edema and thrombotic complications in long-haul flights; jet lag was also evaluated. METHODS: Four hundred and fifty subjects at different risk levels for thrombosis, flying in economy class twice a week for more than 8 hours, were included; 295 completed the registry study and were subdivided in 3 groups according to their risk level - low, moderate, or high. The high-risk group also received Aspirin®...
April 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29511389/clinical-significance-of-hemostatic-parameters-in-the-prediction-for-type-2-diabetes-mellitus-and-diabetic-nephropathy
#20
Lianlian Pan, Yali Ye, Mingyi Wo, Danni Bao, Fengjiao Zhu, Maoliang Cheng, Xiuwen Ni, Xianming Fei
It would be important to predict type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). This study was aimed at evaluating the predicting significance of hemostatic parameters for T2DM and DN. Plasma coagulation and hematologic parameters before treatment were measured in 297 T2DM patients. The risk factors and their predicting power were evaluated. T2DM patients without complications exhibited significantly different activated partial thromboplastin time (aPTT), platelet (PLT), and D-dimer (D-D) levels compared with controls ( P < 0...
2018: Disease Markers
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