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https://www.readbyqxmd.com/read/28534370/research-on-the-coagulation-function-changes-in-non-small-cell-lung-cancer-patients-and-analysis-of-their-correlation-with-metastasis-and-survival
#1
Yongjun Qi, Jingwei Fu
PURPOSE: To investigate the relationship between coagulation function and prognosis of non-small cell lung cancer (NSCLC) patients. METHODS: 539 patients who were admitted to our hospital for the first time from December 2008 to December 2013 and pathologically diagnosed as NSCLC were enrolled in this study (study group), while 80 healthy persons served as controls (control group). Morning fasting venous blood samples were collected for coagulation function indexes, such as prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (Fib), D-dimer (D-D) and platelet count (PLT) and the coagulation function and survival rate were compared...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28522847/a-molecular-basis-for-selective-antagonist-destabilization-of-dopamine-d3-receptor-quaternary-organization
#2
Sara Marsango, Gianluigi Caltabiano, Mireia Jiménez-Rosés, Mark J Millan, John D Pediani, Richard J Ward, Graeme Milligan
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a substantial proportion of the receptor was present within dimeric/oligomeric complexes and that increased expression levels of the receptor favored a greater dimer to monomer ratio. Addition of the antipsychotics, spiperone or haloperidol, resulted in re-organization of D3R quaternary structure to promote monomerization...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522147/cardiovascular-risk-in-advanced-na%C3%A3-ve-hiv-infected-patients-starting-antiretroviral-therapy-comparison-of-three-different-regimens-prevaleat-ii-cohort
#3
Paolo Maggi, Chiara Bellacosa, Armando Leone, Anna Volpe, Elena Delfina Ricci, Nicoletta Ladisa, Stefania Cicalini, Elisabetta Grilli, Rosaria Viglietti, Antonio Chirianni, Lara Ines Bellazzi, Renato Maserati, Canio Martinelli, Paola Corsi, Benedetto Maurizio Celesia, Federica Sozio, Gioacchino Angarano
BACKGROUND AND AIMS: PREVALEAT (PREmature VAscular LEsions and Antiretroviral Therapy) II is a multicenter, longitudinal cohort study aimed at the evaluation of cardiovascular risk among advanced HIV-positive, treatment-naïve patients starting their first therapy. We hypothesized that these patients, present a higher cardiovascular (CV) risk. METHODS: The study included all consecutive naïve patients with less than 200 CD4 cells/ml starting antiretroviral therapy...
May 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28506697/inflammation-and-hemostasis-in-older-octogenarians-implication-in-5-year-survival
#4
Judit Cubedo, Teresa Padró, Francesc Formiga, Assumpta Ferrer, Glòria Padrós, Esther Peña, Lina Badimon
Social changes and medical advances have increased longevity, but the conditions governing healthy vs unhealthy cardiovascular (CV) aging are not fully known. Factors beyond classical CV risk factors may have an important unrecognized value. We sought to identify proteins differentially expressed in healthy octogenarians (HOs) without a history of cardiovascular disease (CVD) and preserved functional and cognitive state compared with octogenarians with a history of CVD and cognitive decline (UHOs) using a systems biology approach, and investigated how these proteins relate to CV mortality at 5-year follow-up...
April 26, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28505148/potential-pathogenesis-and-biomarkers-of-kidney-cancer-related-stroke
#5
Haihong Jiang, Chao Qin, Daobin Cheng, Qiuhong Lu, Gelun Huang, Dacheng Wang, Hong Yang, Zhijian Liang
BACKGROUND Stroke risk and stroke recurrence are increased in cancer patients, but the pathogenesis and biomarkers of kidney cancer-related stroke (KCS) are generally unclear. The aim of the present research was to investigate the pathogenesis and plasma biomarkers of kidney cancer-related stroke. MATERIAL AND METHODS A retrospective review was conducted on acute stroke patients with kidney cancer (KC) who were admitted to the hospital between January 2006 and December 2015. A total of 106 patients with KCS (active KC patients with acute stroke but without conventional vascular risks) were identified...
May 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28498471/sodium-tanshinone-iia-sulfonate-improves-inflammation-aortic-endothelial-cell-apoptosis-disseminated-intravascular-coagulation-and-multiple-organ-damage-in-a-rat-heat-stroke-model
#6
Fang Chen, Huimin Li, Guoguo Zhu, Xiaojuan Chen, Zhongzhi Tang
The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS...
May 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28481220/mrna-mediated-glycoengineering-ameliorates-deficient-homing-of-human-stem-cell-derived-hematopoietic-progenitors
#7
Jungmin Lee, Brad Dykstra, Joel A Spencer, Laurie L Kenney, Dale L Greiner, Leonard D Shultz, Michael A Brehm, Charles P Lin, Robert Sackstein, Derrick J Rossi
Generation of functional hematopoietic stem and progenitor cells (HSPCs) from human pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hematopoietic cell production, disease modeling, and eventually transplantation medicine. Homing of HSPCs from bloodstream to bone marrow (BM) is an important aspect of HSPC biology that has remained unaddressed in efforts to derive functional HSPCs from human PSCs. We have therefore examined the BM homing properties of human induced pluripotent stem cell-derived HSPCs (hiPS-HSPCs)...
May 8, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28476550/disseminated-intravascular-coagulation-is-associated-with-the-neurologic-outcome-of-cardiac-arrest-survivors
#8
Dong Hun Lee, Byung Kook Lee, Kyung Woon Jeung, Yong Hun Jung, Sung Min Lee, Yong Soo Cho, Seong-Woo Yun, Yong Il Min
PURPOSE: We aimed to examine the serial changes in coagulofibrinolytic markers that occurred after the restoration of spontaneous circulation (ROSC) in cardiac arrest patients, who were treated with targeted temperature management (TTM). We also evaluated the association between the disseminated intravascular coagulation (DIC) score and clinical outcomes. METHODS: This was a single-centre, retrospective observational study that included cardiac arrest patients who were treated with TTM from May 2012 to December 2015...
May 1, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28473975/increased-clot-formation-in-the-absence-of-increased-thrombin-generation-in-patients-with-peripheral-arterial-disease-a-case-control-study
#9
Marie-Claire F Kleinegris, Joke Konings, Jan W Daemen, Yvonne Henskens, Bas de Laat, Henri M H Spronk, Arina J Ten Cate-Hoek, Hugo Ten Cate
BACKGROUND: In peripheral arterial disease (PAD), activation of the hemostatic system may contribute to atherosclerosis progression and atherothrombotic events. OBJECTIVE: This case-control study assesses the overall coagulation status in PAD patients by evaluating coagulation markers in combination with thrombin generation potential, whole blood (WB) clot formation, and fibrinolysis. METHODS: In blood from 40 PAD patients (n = 20 with cardiovascular event within 1 year after initial diagnosis, n = 20 without) and 40 apparently healthy controls, thrombin generation was determined in WB and platelet-poor plasma...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28464004/vitamin-d-deficiency-is-associated-with-il-6-levels-and-monocyte-activation-in-hiv-infected-persons
#10
Maura Manion, Katherine Huppler Hullsiek, Eleanor M P Wilson, Frank Rhame, Erna Kojic, David Gibson, John Hammer, Pragna Patel, John T Brooks, Jason V Baker, Irini Sereti
BACKGROUND: Immune activation plays a key role in HIV pathogenesis. Markers of inflammation have been associated with vitamin D deficiency in the general population. Studies have also demonstrated associations of vitamin D deficiency with increased risk of HIV progression and death. The relationship between persistent inflammation and immune activation during chronic HIV infection and vitamin D deficiency remains unclear. METHODS: Cryopreserved specimens were analyzed from 663 participants at the time of enrollment from the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study) from 2004 to 2006...
2017: PloS One
https://www.readbyqxmd.com/read/28450113/a-co-releasing-molecule-prevents-annexin-a2-down-regulation-and-associated-disorders-in-lps-administered-rat-lung
#11
Kana Unuma, Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura
To investigate septic lung injuries and the possible relief from injury by carbon monoxide (CO), rats were intraperitoneally (i.p.) administered water or the water-soluble CO-releasing molecule CORM (30 mg/kg body weight), followed by the successive administration of PBS or lipopolysaccharide (LPS, 15 mg/kg body weight, 6 h). The results in four experimental groups (control, LPS, LPS + CORM, CORM, n = 3 or 4 in each groups) were examined. Histological examination revealed the intravascular aggregation of erythrocytes in the lungs of the LPS group, and serological analysis showed a significant increase in D-dimer in the LPS group...
April 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28449505/pulmonary-vein-stump-thrombosis-after-left-pneumonectomy-diagnosed-based-on-a-high-plasma-d-dimer-level-a-case-report
#12
Tomohiro Kamori, Gouji Toyokawa, Tatsuro Okamoto, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Kazuki Takada, Masakazu Katsura, Fumihiro Shoji, Yoshihiko Maehara
A 69-year-old man with locally advanced squamous cell lung cancer in the left hilum underwent left upper sleeve lobectomy following neoadjuvant chemoradiotherapy with an S-1/cisplatin regimen. On postoperative day (POD) 5, the chest X-ray findings deteriorated, and computed tomography (CT) images showed pulmonary congestion of the left residual lung. We then performed emergent left completion pneumonectomy. Although the Postoperative course after re-operation was uneventful, and the patient was scheduled to be discharged on POD 12 when the serum creatinine level and plasma D-dimer level increased to 1...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28445972/the-prognostic-value-of-d-dimer-levels-in-endometrial-cancer-patients-treated-with-intensity-modulated-radiation-therapy
#13
Xiaojing Yang, Hanru Ren, Yi Sun, Lihua Zhang, Xinmiao Yang, Hongling Li, Yuhui Shao, Jie Fu
Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for endometrial cancer. The D-dimer levels of forty patients with endometrial cancer were assessed before (D1) and after (D2) intensity-modulated radiation therapy (IMRT), respectively. The D-dimer level changes (ΔD) were defined as D2 minus D1...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430802/the-quality-changes-in-fresh-frozen-plasma-of-the-blood-donors-at-high-altitude
#14
Zongkui Wang, Hua Liu, Miaomiao Dou, Xi Du, Jijun Hu, Na Su, Ya Wang, Rong Zhang, Changqing Li
OBJECTIVE: According to the international guidelines, fresh frozen plasma (FFP) is unanimously used to treat coagulation disorders. The quality of FFP is critical for the clinical transfusion. Till now, few studies have integratedly evaluated the differences of FFP from blood donors at between high altitude (HA) and low altitude (LA). Besides, there were no special quality standards for HA FFP in China. MATERIALS AND METHODS: Up to 41 HA (Lhasa, 3700 m) and 46 LA (Chengdu, 500 m) blood donors were included in our study to estimate the differences of FFP from HA and LA blood donors...
2017: PloS One
https://www.readbyqxmd.com/read/28424368/spatial-intensity-distribution-analysis-quantifies-the-extent-and-regulation-of-homo-dimerization-of-the-secretin-receptor
#15
Richard J Ward, John D Pediani, Kaleeckal G Harikumar, Laurence J Miller, Graeme Milligan
Previous studies have indicated that the G protein-coupled secretin receptor is present as a homo-dimer, organized through symmetrical contacts in transmembrane domain IV, and that receptor dimerization is critical for high potency signalling by secretin. However, whether all of the receptor exists in the dimeric form or if this is regulated, is unclear. We used measures of quantal brightness of the secretin receptor tagged with monomeric enhanced green fluorescent protein (mEGFP) and Spatial Intensity Distribution Analysis to assess this...
April 19, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28422420/a-study-of-disseminated-intravascular-coagulation-in-acute-leukemia-reveals-markedly-elevated-d-dimer-levels-are-a-sensitive-indicator-of-acute-promyelocytic-leukemia
#16
N Shahmarvand, J S Oak, M J Cascio, M Alcasid, E Goodman, B C Medeiros, D A Arber, J L Zehnder, R S Ohgami
INTRODUCTION: While the presence of disseminated intravascular coagulation (DIC) has been implicated in worse clinical outcome in acute leukemia, the relationship between different subtypes of acute leukemia and the clinicopathologic features of DIC has not been systematically well studied. METHODS: In this study, we retrospectively reviewed 149 cases of newly diagnosed acute leukemia and assessed the utility of evaluating red blood cell morphologic features, and coagulation parameters in determining the presence of DIC as well as differentiating subtypes of acute leukemia...
April 19, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28418614/efficacy-and-safety-of-low-dose-heparin-in-hemodialysis
#17
Mariana Murea, Gregory B Russell, Pirouz Daeihagh, Anita M Saran, Karan Pandya, Mark Cabrera, John M Burkart, Barry I Freedman
INTRODUCTION: The dose of unfractionated heparin (UFH) administered during hemodialysis (HD) varies widely. This prospective study evaluated the safety and efficacy of UFH dose de-escalation. METHODS: Sixty-six prevalent patients on HD receiving UFH per standard-dose protocol (load dose [LD] 50-75 units/kg, maintenance dose [MD] 500-1000 units/hour) had heparin prescription converted to low-dose protocol (start LD 15 units/kg and MD 500 units/hour; dose adjusted in small increments based on assessments of extracorporeal blood circuit)...
April 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28408834/predictive-values-of-d-dimer-assay-grace-scores-and-timi-scores-for-adverse-outcome-in-patients-with-non-st-segment-elevation-myocardial-infarction
#18
Muhammet Hulusi Satilmisoglu, Sinem Ozbay Ozyilmaz, Mehmet Gul, Hayriye Ak Yildirim, Osman Kayapinar, Kadir Gokturk, Huseyin Aksu, Korhan Erkanli, Abdurrahman Eksik
PURPOSE: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). PATIENTS AND METHODS: A total of 234 patients (mean age: 57.2±11.7 years, 75.2% were males) hospitalized with NSTEMI were included. Data on D-dimer assay, GRACE and TIMI risk scores were recorded. Logistic regression analysis was conducted to determine the risk factors predicting increased mortality...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28391888/inflammatory-markers-modify-the-risk-of-recurrent-coronary-events-associated-with-apolipoprotein-a-i-in-postinfarction-patients
#19
Meng Wang, James Corsetti, Scott McNitt, David Q Rich, Charles E Sparks, Arthur J Moss, Wojciech Zareba
BACKGROUND: Laboratory findings have suggested that systemic and vascular inflammation can impair the antiatherogenic function of high-density lipoproteins (HDLs). However, evidence from population studies is sparse. OBJECTIVE: The objective of the study was to assess if blood inflammatory markers modify the risk of recurrent coronary events associated with apolipoprotein A-I (apoA-I) and HDL cholesterol (HDL-C) among postinfarction patients. METHODS: ApoA-I, HDL-C, and inflammatory markers (C-reactive protein [CRP], serum amyloid A (SAA), fibrinogen, von Willebrand factor [vWF], and D-dimer) were measured from blood samples of 1028 patients drawn 2 months after an index myocardial infarction (MI)...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28384907/a-study-of-haematological-and-haemostasis-parameters-and-hypercoagulable-state-in-tuberculosis-patients-in-northern-india-and-the-outcome-with-anti-tubercular-therapy
#20
Aditya Singh Kutiyal, Naresh Gupta, Sandeep Garg, Harmanjit Singh Hira
INTRODUCTION: Tuberculosis is one of the leading infectious diseases with high morbidity and mortality in the developing countries. Tuberculosis is also rarely associated with hypercoagulable state and very limited literature is available on this association. AIM: To study the haematological and haemostasis laboratory parameters, to correlate the abnormalities for a hypercoagulable state and to study the outcome with anti-tubercular therapy. MATERIALS AND METHODS: The study population included 128 patients with newly diagnosed tuberculosis...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
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