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C W Abell

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https://www.readbyqxmd.com/read/29131575/halogenation-of-biotin-protein-ligase-inhibitors-improves-whole-cell-activity-against-staphylococcus-aureus
#1
Ashleigh S Paparella, Kwang Jun Lee, Andrew J Hayes, Jiage Feng, Zikai Feng, Danielle Cini, Sonali Deshmukh, Grant W Booker, Matthew C J Wilce, Steven W Polyak, Andrew D Abell
We report the synthesis and evaluation of 5-halogenated-1,2,3-triazoles as inhibitors of biotin protein ligase from Staphylococcus aureus. The halogenated compounds exhibit significantly improved antibacterial activity over their nonhalogenated counterparts. Importantly, the 5-fluoro-1,2,3-triazole compound 4c displays antibacterial activity against S. aureus ATCC49775 with a minimum inhibitory concentration (MIC) of 8 μg/mL.
November 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29107474/breakfast-quality-varies-by-location-among-low-income-ethnically-diverse-children-in-public-urban-schools
#2
Heather M Polonsky, Adam Davey, Katherine W Bauer, Gary D Foster, Sandy Sherman, Michelle L Abel, Lauren C Dale, Jennifer O Fisher
OBJECTIVE: To evaluate breakfast location and children's food choices. METHODS: Cross-sectional analysis of 1,371 fourth- through sixth-grade students in 2013. Foods and beverages in 17 categories characterized breakfast choices: (1) ≥ 1 fruits or vegetables, (2) ≥ 1 foods high in saturated fats and added sugars (SFAS), and (3) meeting School Breakfast Program (SBP) requirements. RESULTS: Among breakfast eaters (n = 1,133; 82...
October 26, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29068864/monitoring-training-load-in-handcycling-a-case-study
#3
Sebastian Zeller, Thomas Abel, Heiko K Strueder
Zeller, S, Abel, T, and Strueder, HK. Monitoring training load in handcycling: a case study. J Strength Cond Res 31(11): 3094-3100, 2017-The aim of this study was to analyze the training intensity distribution (TID) and the total training load (TTL) for the first time in handcycling of a multiple female Paralympic medalist (lesion level: L2-3 incomplete, ASIA C, classification: WH5). This study focuses on the preparation and the competitive period of the 2015 season. The athlete completed 194 handcycling training sessions in a time of 433:53 hours, covering a total distance of 10...
November 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29038598/male-specific-deficits-in-natural-reward-learning-in-a-mouse-model-of-neurodevelopmental-disorders
#4
N M Grissom, S E McKee, H Schoch, N Bowman, R Havekes, W T O'Brien, E Mahrt, S Siegel, K Commons, C Portfors, T Nickl-Jockschat, T M Reyes, T Abel
Neurodevelopmental disorders, including autism spectrum disorders, are highly male biased, but the underpinnings of this are unknown. Striatal dysfunction has been strongly implicated in the pathophysiology of neurodevelopmental disorders, raising the question of whether there are sex differences in how the striatum is impacted by genetic risk factors linked to neurodevelopmental disorders. Here we report male-specific deficits in striatal function important to reward learning in a mouse model of 16p11.2 hemideletion, a genetic mutation that is strongly associated with the risk of neurodevelopmental disorders, particularly autism and attention-deficit hyperactivity disorder...
October 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28802241/the-9-d-cidr-pg-protocol-ii-characterization-of-endocrine-parameters-ovarian-dynamics-and-pregnancy-rates-to-fixed-time-ai-following-use-of-long-term-cidr-based-estrus-synchronization-among-mature-beef-cows
#5
J M Thomas, J W C Locke, B E Bishop, J M Abel, M R Ellersieck, S E Poock, M F Smith, D J Patterson
An experiment was designed to evaluate endocrine parameters, ovarian dynamics, and pregnancy rates to fixed-time artificial insemination (FTAI) following the 9-d CIDR-PG protocol in comparison to the 14-d CIDR-PG protocol. While both are long-term protocols using CIDR treatment for presynchronization, the 9-d CIDR-PG protocol differs from the 14-d CIDR-PG protocol in that prostaglandin F2α (PG) is administered at CIDR insertion and removal to facilitate a decreased length of progestin treatment and potentially enhance response to the presynchronization treatment...
November 2017: Theriogenology
https://www.readbyqxmd.com/read/28679317/oleiferoside-w-from-the-roots-of-camellia-oleifera-c-abel-inducing-cell-cycle-arrest-and-apoptosis-in-a549-cells
#6
Jiang-Ping Wu, Nai-Xin Kang, Mi-Ya Zhang, Hong-Wei Gao, Xiao-Ran Li, Yan-Li Liu, Qiong-Ming Xu, Shi-Lin Yang
Camellia oleifera C. Abel has been widely cultivated in China, and a group of bioactive constituents such as triterpeniod saponin have been isolated from C. oleifera C. Abel. In the current study, a new triterpeniod saponin was isolated from the EtOH extract of the roots of C. oleifera C. Abel, named as oleiferoside W, and the cytotoxic properties of oleiferoside W were evaluated in non-small cell lung cancer A549 cells. At the same time the inducing apoptosis, the depolarization of mitochondrial membrane potential (Δψ), the up-regulation of related pro-apoptotic proteins, such as cleaved-PARP, cleaved-caspase-3, and the down-regulation of anti-apoptotic marker Bcl-2/Bax were measured on oleiferoside W...
July 6, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28606988/recurrent-rhinovirus-infections-in-a-child-with-inherited-mda5-deficiency
#7
Ian T Lamborn, Huie Jing, Yu Zhang, Scott B Drutman, Jordan K Abbott, Shirin Munir, Sangeeta Bade, Heardley M Murdock, Celia P Santos, Linda G Brock, Evan Masutani, Emmanuel Y Fordjour, Joshua J McElwee, Jason D Hughes, Dave P Nichols, Aziz Belkadi, Andrew J Oler, Corinne S Happel, Helen F Matthews, Laurent Abel, Peter L Collins, Kanta Subbarao, Erwin W Gelfand, Michael J Ciancanelli, Jean-Laurent Casanova, Helen C Su
MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts and intermediates. We studied a child with life-threatening, recurrent respiratory tract infections, caused by viruses including human rhinovirus (HRV), influenza virus, and respiratory syncytial virus (RSV). We identified in her a homozygous missense mutation in IFIH1 that encodes MDA5. Mutant MDA5 was expressed but did not recognize the synthetic MDA5 agonist/(ds)RNA mimic polyinosinic-polycytidylic acid. When overexpressed, mutant MDA5 failed to drive luciferase activity from the IFNB1 promoter or promoters containing ISRE or NF-κB sequence motifs...
July 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28586395/the-her2-phenotype-of-circulating-tumor-cells-in-her2-positive-early-breast-cancer-a-translational-research-project-of-a-prospective-randomized-phase-iii-trial
#8
RANDOMIZED CONTROLLED TRIAL
B A S Jaeger, J Neugebauer, U Andergassen, C Melcher, F Schochter, D Mouarrawy, G Ziemendorff, M Clemens, E V Abel, G Heinrich, K Schueller, A Schneeweiss, P Fasching, M W Beckmann, Ch Scholz, T W P Friedl, K Friese, K Pantel, T Fehm, W Janni, B Rack
BACKGROUND: HER2 is one of the predominant therapeutic targets in breast cancer. The metastatic selection process may lead to discrepancies between the HER2 status of the primary tumor and circulating tumor cells (CTCs). This study analyzed the HER2 status of CTCs in patients with HER2-positive primary breast cancer at the time of diagnosis. Aim of the study was to assess potential discordance of HER2 status between primary tumor and CTCs, as this may have important implications for the use of HER2-targeted therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28538523/the-effect-of-maternal-milk-on-tolerance-and-growth-in-premature-infants-a-hypothesis-generating-study
#9
Jacomine E Hogewind-Schoonenboom, Lyanne W W Rövekamp-Abels, Daphne P M de Wijs-Meijler, Margaux D Maduro, Marijke C Jansen-van der Weide, Johannes B van Goudoever, Jessie M Hulst
OBJECTIVE: Early growth rates and feeding advancement rates of preterm infants are thought to influence later health. Feeding advancement is often difficult because of feeding intolerance. Exclusive human milk feeding improves tolerance, but can result in a lower weight gain rate. The addition of human milk fortifier has advantages for growth, but there are concerns that it may nullify the beneficial effect of human milk on tolerance. Therefore, the objective of the present study was to evaluate the relation between the amount of fortified human milk or formula and feeding tolerance and growth in preterm infants...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28479280/pelagic-and-benthic-communities-of-the-antarctic-ecosystem-of-potter-cove-genomics-and-ecological-implications
#10
REVIEW
D Abele, S Vazquez, A G J Buma, E Hernandez, C Quiroga, C Held, S Frickenhaus, L Harms, J L Lopez, E Helmke, W P Mac Cormack
Molecular technologies are more frequently applied in Antarctic ecosystem research and the growing amount of sequence-based information available in databases adds a new dimension to understanding the response of Antarctic organisms and communities to environmental change. We apply molecular techniques, including fingerprinting, and amplicon and metagenome sequencing, to understand biodiversity and phylogeography to resolve adaptive processes in an Antarctic coastal ecosystem from microbial to macrobenthic organisms and communities...
June 2017: Marine Genomics
https://www.readbyqxmd.com/read/28474788/in-vivo-targeting-of-protein-antigens-to-dendritic-cells-using-anti-dec-205-single-chain-antibody-improves-hiv-gag-specific-cd4-t-cell-responses-protecting-from-airway-challenge-with-recombinant-vaccinia-gag-virus
#11
Loveline N Ngu, Nadesh N Nji, Georgia E Ambada, Bertrand Sagnia, Carol Ngane Sake, Jules Colinc Tchadji, Ghislain Donald Njambe Priso, Abel Lissom, Thibau Flaurant Tchouangueu, Denis Manga Tebit, Alain Bopda Waffo, Chae Gyu Park, Ralph M Steinman, Klaus Überla, Godwin W Nchinda
INTRODUCTION: Targeting antigens to dendritic cells (DCs) in vivo via a DC-restricted endocytic receptor, DEC205, has been validated to enhance immunity in several vaccine platforms. Particularly atttractive is selected delivery of proteins to DCs in vivo because it enables proteins to be more immunogenic and provides a cheaper and effective way for repeated immunizations. METHODS: In this study, we tested the efficacy of a single chain antibody to DEC205 (scDEC) to deliver protein antigens selectively to DCs in vivo and to induce protective immunity...
March 13, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28462931/neurons-and-neuronal-activity-control-gene-expression-in-astrocytes-to-regulate-their-development-and-metabolism
#12
Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C Todd, Samuel Heron, Nóra M Márkus, Jamie McQueen, David W Hampton, Megan Torvell, Sachin S Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J A Wyllie, T Ian Simpson, Giles E Hardingham
The influence that neurons exert on astrocytic function is poorly understood. To investigate this, we first developed a system combining cortical neurons and astrocytes from closely related species, followed by RNA-seq and in silico species separation. This approach uncovers a wide programme of neuron-induced astrocytic gene expression, involving Notch signalling, which drives and maintains astrocytic maturity and neurotransmitter uptake function, is conserved in human development, and is disrupted by neurodegeneration...
May 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28462363/data-on-the-fungal-species-consumed-by-mammal-species-in-australia
#13
S J Nuske, K Vernes, T W May, A W Claridge, B C Congdon, A Krockenberger, S E Abell
The data reported here support the manuscript Nuske et al. (2017) [1]. Searches were made for quantitative data on the occurrence of fungi within dietary studies of Australian mammal species. The original location reported in each study was used as the lowest grouping variable within the dataset. To standardise the data and compare dispersal events from populations of different mammal species that might overlap, data from locations were further pooled and averaged across sites if they occurred within 100 km of a random central point...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28288017/task-induced-changes-in-idiopathic-infantile-nystagmus-vary-with-gaze
#14
Marzieh Salehi Fadardi, Arne C Bathke, Solomon W Harrar, Larry Allen Abel
PURPOSE: Investigations of infantile nystagmus syndrome (INS) at center or at the null position have reported that INS worsens when visual demand is combined with internal states, e.g. stress. Visual function and INS parameters such as foveation time, frequency, amplitude, and intensity can also be influenced by gaze position. We hypothesized that increases from baseline in visual demand and mental load would affect INS parameters at the null position differently than at other gaze positions...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28237335/evaluation-of-the-14-d-cidr-pg-and-9-d-cidr-pg-protocols-for-synchronization-of-estrus-in-bos-indicus-influenced-and-bos-taurus-beef-heifers
#15
J M Thomas, J W C Locke, B E Bishop, J M Abel, M R Ellersieck, J V Yelich, S E Poock, M F Smith, D J Patterson
Two long-term, CIDR-based estrus synchronization protocols were evaluated among Bos indicus-influenced and Bos taurus beef heifers. Treatments were evaluated on the basis of estrous response and pregnancy rate resulting from fixed-time artificial insemination (FTAI), and these outcomes were analyzed retrospectively relative to reproductive tract score (RTS; Scale 1-5) at treatment initiation. Estrus was synchronized for 1139 heifers in three locations, and heifers were assigned to one of two treatments within each location based on RTS...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28222112/genome-wide-study-of-resistant-hypertension-identified-from-electronic-health-records
#16
Logan Dumitrescu, Marylyn D Ritchie, Joshua C Denny, Nihal M El Rouby, Caitrin W McDonough, Yuki Bradford, Andrea H Ramirez, Suzette J Bielinski, Melissa A Basford, High Seng Chai, Peggy Peissig, David Carrell, Jyotishman Pathak, Luke V Rasmussen, Xiaoming Wang, Jennifer A Pacheco, Abel N Kho, M Geoffrey Hayes, Martha Matsumoto, Maureen E Smith, Rongling Li, Rhonda M Cooper-DeHoff, Iftikhar J Kullo, Christopher G Chute, Rex L Chisholm, Gail P Jarvik, Eric B Larson, David Carey, Catherine A McCarty, Marc S Williams, Dan M Roden, Erwin Bottinger, Julie A Johnson, Mariza de Andrade, Dana C Crawford
Resistant hypertension is defined as high blood pressure that remains above treatment goals in spite of the concurrent use of three antihypertensive agents from different classes. Despite the important health consequences of resistant hypertension, few studies of resistant hypertension have been conducted. To perform a genome-wide association study for resistant hypertension, we defined and identified cases of resistant hypertension and hypertensives with treated, controlled hypertension among >47,500 adults residing in the US linked to electronic health records (EHRs) and genotyped as part of the electronic MEdical Records & GEnomics (eMERGE) Network...
2017: PloS One
https://www.readbyqxmd.com/read/28214038/maximising-synergy-among-tropical-plant-systematists-ecologists-and-evolutionary-biologists
#17
REVIEW
Timothy R Baker, R Toby Pennington, Kyle G Dexter, Paul V A Fine, Helen Fortune-Hopkins, Euridice N Honorio, Isau Huamantupa-Chuquimaco, Bente B Klitgård, Gwilym P Lewis, Haroldo C de Lima, Peter Ashton, Christopher Baraloto, Stuart Davies, Michael J Donoghue, Maria Kaye, W John Kress, Caroline E R Lehmann, Abel Monteagudo, Oliver L Phillips, Rodolfo Vasquez
Closer collaboration among ecologists, systematists, and evolutionary biologists working in tropical forests, centred on studies within long-term permanent plots, would be highly beneficial for their respective fields. With a key unifying theme of the importance of vouchered collection and precise identification of species, especially rare ones, we identify four priority areas where improving links between these communities could achieve significant progress in biodiversity and conservation science: (i) increasing the pace of species discovery; (ii) documenting species turnover across space and time; (iii) improving models of ecosystem change; and (iv) understanding the evolutionary assembly of communities and biomes...
April 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28187516/collaborating-to-compete-blood-profiling-atlas-in-cancer-bloodpac-consortium
#18
REVIEW
R L Grossman, B Abel, S Angiuoli, J C Barrett, D Bassett, K Bramlett, G M Blumenthal, A Carlsson, R Cortese, J DiGiovanna, B Davis-Dusenbery, R Dittamore, D A Eberhard, P Febbo, M Fitzsimons, Z Flamig, J Godsey, J Goswami, A Gruen, F Ortuño, J Han, D Hayes, J Hicks, D Holloway, D Hovelson, J Johnson, H Juhl, R Kalamegham, R Kamal, Q Kang, G J Kelloff, M Klozenbuecher, A Kolatkar, P Kuhn, K Langone, R Leary, P Loverso, H Manmathan, A-M Martin, J Martini, D Miller, M Mitchell, T Morgan, R Mulpuri, T Nguyen, G Otto, A Pathak, E Peters, R Philip, E Posadas, D Reese, M G Reese, D Robinson, A Dei Rossi, H Sakul, J Schageman, S Singh, H I Scher, K Schmitt, A Silvestro, J Simmons, T Simmons, J Sislow, A Talasaz, P Tang, M Tewari, S Tomlins, H Toukhy, H R Tseng, M Tuck, A Tzou, J Vinson, Y Wang, W Wells, A Welsh, J Wilbanks, J Wolf, L Young, Jsh Lee, L C Leiman
The cancer community understands the value of blood profiling measurements in assessing and monitoring cancer. We describe an effort among academic, government, biotechnology, diagnostic, and pharmaceutical companies called the Blood Profiling Atlas in Cancer (BloodPAC) Project. BloodPAC will aggregate, make freely available, and harmonize for further analyses, raw datasets, relevant associated clinical data (e.g., clinical diagnosis, treatment history, and outcomes), and sample preparation and handling protocols to accelerate the development of blood profiling assays...
May 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28094794/diversity-and-carbon-storage-across-the-tropical-forest-biome
#19
Martin J P Sullivan, Joey Talbot, Simon L Lewis, Oliver L Phillips, Lan Qie, Serge K Begne, Jerôme Chave, Aida Cuni-Sanchez, Wannes Hubau, Gabriela Lopez-Gonzalez, Lera Miles, Abel Monteagudo-Mendoza, Bonaventure Sonké, Terry Sunderland, Hans Ter Steege, Lee J T White, Kofi Affum-Baffoe, Shin-Ichiro Aiba, Everton Cristo de Almeida, Edmar Almeida de Oliveira, Patricia Alvarez-Loayza, Esteban Álvarez Dávila, Ana Andrade, Luiz E O C Aragão, Peter Ashton, Gerardo A Aymard C, Timothy R Baker, Michael Balinga, Lindsay F Banin, Christopher Baraloto, Jean-Francois Bastin, Nicholas Berry, Jan Bogaert, Damien Bonal, Frans Bongers, Roel Brienen, José Luís C Camargo, Carlos Cerón, Victor Chama Moscoso, Eric Chezeaux, Connie J Clark, Álvaro Cogollo Pacheco, James A Comiskey, Fernando Cornejo Valverde, Eurídice N Honorio Coronado, Greta Dargie, Stuart J Davies, Charles De Canniere, Marie Noel Djuikouo K, Jean-Louis Doucet, Terry L Erwin, Javier Silva Espejo, Corneille E N Ewango, Sophie Fauset, Ted R Feldpausch, Rafael Herrera, Martin Gilpin, Emanuel Gloor, Jefferson S Hall, David J Harris, Terese B Hart, Kuswata Kartawinata, Lip Khoon Kho, Kanehiro Kitayama, Susan G W Laurance, William F Laurance, Miguel E Leal, Thomas Lovejoy, Jon C Lovett, Faustin Mpanya Lukasu, Jean-Remy Makana, Yadvinder Malhi, Leandro Maracahipes, Beatriz S Marimon, Ben Hur Marimon Junior, Andrew R Marshall, Paulo S Morandi, John Tshibamba Mukendi, Jaques Mukinzi, Reuben Nilus, Percy Núñez Vargas, Nadir C Pallqui Camacho, Guido Pardo, Marielos Peña-Claros, Pascal Pétronelli, Georgia C Pickavance, Axel Dalberg Poulsen, John R Poulsen, Richard B Primack, Hari Priyadi, Carlos A Quesada, Jan Reitsma, Maxime Réjou-Méchain, Zorayda Restrepo, Ervan Rutishauser, Kamariah Abu Salim, Rafael P Salomão, Ismayadi Samsoedin, Douglas Sheil, Rodrigo Sierra, Marcos Silveira, J W Ferry Slik, Lisa Steel, Hermann Taedoumg, Sylvester Tan, John W Terborgh, Sean C Thomas, Marisol Toledo, Peter M Umunay, Luis Valenzuela Gamarra, Ima Célia Guimarães Vieira, Vincent A Vos, Ophelia Wang, Simon Willcock, Lise Zemagho
Tropical forests are global centres of biodiversity and carbon storage. Many tropical countries aspire to protect forest to fulfil biodiversity and climate mitigation policy targets, but the conservation strategies needed to achieve these two functions depend critically on the tropical forest tree diversity-carbon storage relationship. Assessing this relationship is challenging due to the scarcity of inventories where carbon stocks in aboveground biomass and species identifications have been simultaneously and robustly quantified...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28066953/diabetic-and-idiopathic-gastroparesis-is-associated-with-loss-of-cd206-positive-macrophages-in-the-gastric-antrum
#20
M Grover, C E Bernard, P J Pasricha, H P Parkman, S J Gibbons, J Tonascia, K L Koch, R W McCallum, I Sarosiek, W L Hasler, L A B Nguyen, T L Abell, W J Snape, M L Kendrick, T A Kellogg, T J McKenzie, F A Hamilton, G Farrugia
BACKGROUND: Animal studies have increasingly highlighted the role of macrophages in the development of delayed gastric emptying. However, their role in the pathophysiology of human gastroparesis is unclear. Our aim was to determine changes in macrophages and other cell types in the gastric antrum muscularis propria of patients with diabetic and idiopathic gastroparesis. METHODS: Full thickness gastric antrum biopsies were obtained from patients enrolled in the Gastroparesis Clinical Research Consortium (11 diabetic, 6 idiopathic) and 5 controls...
June 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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