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https://www.readbyqxmd.com/read/29307548/rigor-and-reproducibility-in-rodent-behavioral-research
#1
Maria Gulinello, Heather A Mitchell, Qiang Chang, W Timothy O'Brien, Zhaolan Zhou, Ted Abel, Li Wang, Joshua G Corbin, Surabi Veeraragavan, Rodney C Samaco, Nick A Andrews, Michela Fagiolini, Toby B Cole, Thomas M Burbacher, Jacqueline N Crawley
Behavioral neuroscience research incorporates the identical high level of meticulous methodologies and exacting attention to detail as all other scientific disciplines. To achieve maximal rigor and reproducibility of findings, well-trained investigators employ a variety of established best practices. Here we explicate some of the requirements for rigorous experimental design and accurate data analysis in conducting mouse and rat behavioral tests. Novel object recognition is used as an example of a cognitive assay which has been conducted successfully with a range of methods, all based on common principles of appropriate procedures, controls, and statistics...
January 4, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29205929/dendritic-cell-targeted-hiv-1-gag-protein-vaccine-provides-help-to-a-recombinant-newcastle-disease-virus-vectored-vaccine-including-mobilization-of-protective-cd8-t-cells
#2
Loveline N Ngu, Nadesh N Nji, Georgia Ambada, Apeh A Ngoh, Ghislain D Njambe Priso, Jules C Tchadji, Abel Lissom, Suzanne H Magagoum, Carol N Sake, Thibau F Tchouangueu, George O Chukwuma, Arinze S Okoli, Bertrand Sagnia, Rebecca Chukwuanukwu, Denis M Tebit, Charles O Esimone, Alain B Waffo, Chae G Park, Klaus Überla, Godwin W Nchinda
INTRODUCTION: Recombinant Newcastle Disease virus (rNDV) vectored vaccines are safe mucosal applicable vaccines with intrinsic immune-modulatory properties for the induction of efficient immunity. Like all viral vectored vaccines repeated inoculation via mucosal routes invariably results to immunity against viral vaccine vectors. To obviate immunity against viral vaccine vectors and improve the ability of rNDV vectored vaccines in inducing T cell immunity in murine air way we have directed dendritic cell targeted HIV-1 gag protein (DEC-Gag) vaccine; for the induction of helper CD4+ T cells to a Recombinant Newcastle disease virus expressing codon optimized HIV-1 Gag P55 (rNDV-L-Gag) vaccine...
December 4, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29182609/variation-in-fast-track-referrals-for-suspected-cancer-by-patient-characteristic-and-cancer-diagnosis-evidence-from-670%C3%A2-000-patients-with-cancers-of-35-different-sites
#3
Y Zhou, S C Mendonca, G A Abel, W Hamilton, F M Walter, S Johnson, J Shelton, L Elliss-Brookes, S McPhail, G Lyratzopoulos
BACKGROUND: In England, 'fast-track' (also known as 'two-week wait') general practitioner referrals for suspected cancer in symptomatic patients are used to shorten diagnostic intervals and are supported by clinical guidelines. However, the use of the fast-track pathway may vary for different patient groups. METHODS: We examined data from 669 220 patients with 35 cancers diagnosed in 2006-2010 following either fast-track or 'routine' primary-to-secondary care referrals using 'Routes to Diagnosis' data...
November 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29168322/biosynthetically-guided-structure-activity-relationship-studies-of-merochlorin%C3%A2-a-an-antibiotic-marine-natural-product
#4
Borja López-Pérez, Henry P Pepper, Rong Ma, Benjamin J Fawcett, Ashok D Pehere, Qi Wei, Zengchun Ji, Steven W Polyak, Huanqin Dai, Fuhang Song, Andrew D Abell, Lixin Zhang, Jonathan H George
The onset of new multidrug-resistant strains of bacteria demands continuous development of antibacterial agents with new chemical scaffolds and mechanisms of action. We present the first structure-activity relationship (SAR) study of 16 derivatives of a structurally novel antibiotic merochlorin A that were designed using a biosynthetic blueprint. Our lead compounds are active against several Gram-positive bacteria such as Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE) and Bacillus subtilis, inhibit intracellular growth of Mycobacterium bovis, and are relatively nontoxic to human cell lines...
November 23, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29131575/halogenation-of-biotin-protein-ligase-inhibitors-improves-whole-cell-activity-against-staphylococcus-aureus
#5
Ashleigh S Paparella, Kwang Jun Lee, Andrew J Hayes, Jiage Feng, Zikai Feng, Danielle Cini, Sonali Deshmukh, Grant W Booker, Matthew C J Wilce, Steven W Polyak, Andrew D Abell
We report the synthesis and evaluation of 5-halogenated-1,2,3-triazoles as inhibitors of biotin protein ligase from Staphylococcus aureus. The halogenated compounds exhibit significantly improved antibacterial activity over their nonhalogenated counterparts. Importantly, the 5-fluoro-1,2,3-triazole compound 4c displays antibacterial activity against S. aureus ATCC49775 with a minimum inhibitory concentration (MIC) of 8 μg/mL.
November 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29107474/breakfast-quality-varies-by-location-among-low-income-ethnically-diverse-children-in-public-urban-schools
#6
Heather M Polonsky, Adam Davey, Katherine W Bauer, Gary D Foster, Sandy Sherman, Michelle L Abel, Lauren C Dale, Jennifer O Fisher
OBJECTIVE: To evaluate breakfast location and children's food choices. METHODS: Cross-sectional analysis of 1,371 fourth- through sixth-grade students in 2013. Foods and beverages in 17 categories characterized breakfast choices: (1) ≥ 1 fruits or vegetables, (2) ≥ 1 foods high in saturated fats and added sugars (SFAS), and (3) meeting School Breakfast Program (SBP) requirements. RESULTS: Among breakfast eaters (n = 1,133; 82...
October 26, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29068864/monitoring-training-load-in-handcycling-a-case-study
#7
Sebastian Zeller, Thomas Abel, Heiko K Strueder
Zeller, S, Abel, T, and Strueder, HK. Monitoring training load in handcycling: a case study. J Strength Cond Res 31(11): 3094-3100, 2017-The aim of this study was to analyze the training intensity distribution (TID) and the total training load (TTL) for the first time in handcycling of a multiple female Paralympic medalist (lesion level: L2-3 incomplete, ASIA C, classification: WH5). This study focuses on the preparation and the competitive period of the 2015 season. The athlete completed 194 handcycling training sessions in a time of 433:53 hours, covering a total distance of 10...
November 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29038598/male-specific-deficits-in-natural-reward-learning-in-a-mouse-model-of-neurodevelopmental-disorders
#8
N M Grissom, S E McKee, H Schoch, N Bowman, R Havekes, W T O'Brien, E Mahrt, S Siegel, K Commons, C Portfors, T Nickl-Jockschat, T M Reyes, T Abel
Neurodevelopmental disorders, including autism spectrum disorders, are highly male biased, but the underpinnings of this are unknown. Striatal dysfunction has been strongly implicated in the pathophysiology of neurodevelopmental disorders, raising the question of whether there are sex differences in how the striatum is impacted by genetic risk factors linked to neurodevelopmental disorders. Here we report male-specific deficits in striatal function important to reward learning in a mouse model of 16p11.2 hemideletion, a genetic mutation that is strongly associated with the risk of neurodevelopmental disorders, particularly autism and attention-deficit hyperactivity disorder...
October 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28802241/the-9-d-cidr-pg-protocol-ii-characterization-of-endocrine-parameters-ovarian-dynamics-and-pregnancy-rates-to-fixed-time-ai-following-use-of-long-term-cidr-based-estrus-synchronization-among-mature-beef-cows
#9
J M Thomas, J W C Locke, B E Bishop, J M Abel, M R Ellersieck, S E Poock, M F Smith, D J Patterson
An experiment was designed to evaluate endocrine parameters, ovarian dynamics, and pregnancy rates to fixed-time artificial insemination (FTAI) following the 9-d CIDR-PG protocol in comparison to the 14-d CIDR-PG protocol. While both are long-term protocols using CIDR treatment for presynchronization, the 9-d CIDR-PG protocol differs from the 14-d CIDR-PG protocol in that prostaglandin F2α (PG) is administered at CIDR insertion and removal to facilitate a decreased length of progestin treatment and potentially enhance response to the presynchronization treatment...
November 2017: Theriogenology
https://www.readbyqxmd.com/read/28679317/oleiferoside-w-from-the-roots-of-camellia-oleifera-c-abel-inducing-cell-cycle-arrest-and-apoptosis-in-a549-cells
#10
Jiang-Ping Wu, Nai-Xin Kang, Mi-Ya Zhang, Hong-Wei Gao, Xiao-Ran Li, Yan-Li Liu, Qiong-Ming Xu, Shi-Lin Yang
Camellia oleifera C. Abel has been widely cultivated in China, and a group of bioactive constituents such as triterpeniod saponin have been isolated from C. oleifera C. Abel. In the current study, a new triterpeniod saponin was isolated from the EtOH extract of the roots of C. oleifera C. Abel, named as oleiferoside W, and the cytotoxic properties of oleiferoside W were evaluated in non-small cell lung cancer A549 cells. At the same time the inducing apoptosis, the depolarization of mitochondrial membrane potential (Δψ), the up-regulation of related pro-apoptotic proteins, such as cleaved-PARP, cleaved-caspase-3, and the down-regulation of anti-apoptotic marker Bcl-2/Bax were measured on oleiferoside W...
July 6, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28606988/recurrent-rhinovirus-infections-in-a-child-with-inherited-mda5-deficiency
#11
Ian T Lamborn, Huie Jing, Yu Zhang, Scott B Drutman, Jordan K Abbott, Shirin Munir, Sangeeta Bade, Heardley M Murdock, Celia P Santos, Linda G Brock, Evan Masutani, Emmanuel Y Fordjour, Joshua J McElwee, Jason D Hughes, Dave P Nichols, Aziz Belkadi, Andrew J Oler, Corinne S Happel, Helen F Matthews, Laurent Abel, Peter L Collins, Kanta Subbarao, Erwin W Gelfand, Michael J Ciancanelli, Jean-Laurent Casanova, Helen C Su
MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts and intermediates. We studied a child with life-threatening, recurrent respiratory tract infections, caused by viruses including human rhinovirus (HRV), influenza virus, and respiratory syncytial virus (RSV). We identified in her a homozygous missense mutation in IFIH1 that encodes MDA5. Mutant MDA5 was expressed but did not recognize the synthetic MDA5 agonist/(ds)RNA mimic polyinosinic-polycytidylic acid. When overexpressed, mutant MDA5 failed to drive luciferase activity from the IFNB1 promoter or promoters containing ISRE or NF-κB sequence motifs...
July 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28586395/the-her2-phenotype-of-circulating-tumor-cells-in-her2-positive-early-breast-cancer-a-translational-research-project-of-a-prospective-randomized-phase-iii-trial
#12
RANDOMIZED CONTROLLED TRIAL
B A S Jaeger, J Neugebauer, U Andergassen, C Melcher, F Schochter, D Mouarrawy, G Ziemendorff, M Clemens, E V Abel, G Heinrich, K Schueller, A Schneeweiss, P Fasching, M W Beckmann, Ch Scholz, T W P Friedl, K Friese, K Pantel, T Fehm, W Janni, B Rack
BACKGROUND: HER2 is one of the predominant therapeutic targets in breast cancer. The metastatic selection process may lead to discrepancies between the HER2 status of the primary tumor and circulating tumor cells (CTCs). This study analyzed the HER2 status of CTCs in patients with HER2-positive primary breast cancer at the time of diagnosis. Aim of the study was to assess potential discordance of HER2 status between primary tumor and CTCs, as this may have important implications for the use of HER2-targeted therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28538523/the-effect-of-maternal-milk-on-tolerance-and-growth-in-premature-infants-a-hypothesis-generating-study
#13
Jacomine E Hogewind-Schoonenboom, Lyanne W W Rövekamp-Abels, Daphne P M de Wijs-Meijler, Margaux D Maduro, Marijke C Jansen-van der Weide, Johannes B van Goudoever, Jessie M Hulst
OBJECTIVE: Early growth rates and feeding advancement rates of preterm infants are thought to influence later health. Feeding advancement is often difficult because of feeding intolerance. Exclusive human milk feeding improves tolerance, but can result in a lower weight gain rate. The addition of human milk fortifier has advantages for growth, but there are concerns that it may nullify the beneficial effect of human milk on tolerance. Therefore, the objective of the present study was to evaluate the relation between the amount of fortified human milk or formula and feeding tolerance and growth in preterm infants...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28479280/pelagic-and-benthic-communities-of-the-antarctic-ecosystem-of-potter-cove-genomics-and-ecological-implications
#14
REVIEW
D Abele, S Vazquez, A G J Buma, E Hernandez, C Quiroga, C Held, S Frickenhaus, L Harms, J L Lopez, E Helmke, W P Mac Cormack
Molecular technologies are more frequently applied in Antarctic ecosystem research and the growing amount of sequence-based information available in databases adds a new dimension to understanding the response of Antarctic organisms and communities to environmental change. We apply molecular techniques, including fingerprinting, and amplicon and metagenome sequencing, to understand biodiversity and phylogeography to resolve adaptive processes in an Antarctic coastal ecosystem from microbial to macrobenthic organisms and communities...
June 2017: Marine Genomics
https://www.readbyqxmd.com/read/28474788/in-vivo-targeting-of-protein-antigens-to-dendritic-cells-using-anti-dec-205-single-chain-antibody-improves-hiv-gag-specific-cd4-t-cell-responses-protecting-from-airway-challenge-with-recombinant-vaccinia-gag-virus
#15
Loveline N Ngu, Nadesh N Nji, Georgia E Ambada, Bertrand Sagnia, Carol Ngane Sake, Jules Colinc Tchadji, Ghislain Donald Njambe Priso, Abel Lissom, Thibau Flaurant Tchouangueu, Denis Manga Tebit, Alain Bopda Waffo, Chae Gyu Park, Ralph M Steinman, Klaus Überla, Godwin W Nchinda
INTRODUCTION: Targeting antigens to dendritic cells (DCs) in vivo via a DC-restricted endocytic receptor, DEC205, has been validated to enhance immunity in several vaccine platforms. Particularly atttractive is selected delivery of proteins to DCs in vivo because it enables proteins to be more immunogenic and provides a cheaper and effective way for repeated immunizations. METHODS: In this study, we tested the efficacy of a single chain antibody to DEC205 (scDEC) to deliver protein antigens selectively to DCs in vivo and to induce protective immunity...
March 13, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28462931/neurons-and-neuronal-activity-control-gene-expression-in-astrocytes-to-regulate-their-development-and-metabolism
#16
Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C Todd, Samuel Heron, Nóra M Márkus, Jamie McQueen, David W Hampton, Megan Torvell, Sachin S Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J A Wyllie, T Ian Simpson, Giles E Hardingham
The influence that neurons exert on astrocytic function is poorly understood. To investigate this, we first developed a system combining cortical neurons and astrocytes from closely related species, followed by RNA-seq and in silico species separation. This approach uncovers a wide programme of neuron-induced astrocytic gene expression, involving Notch signalling, which drives and maintains astrocytic maturity and neurotransmitter uptake function, is conserved in human development, and is disrupted by neurodegeneration...
May 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28462363/data-on-the-fungal-species-consumed-by-mammal-species-in-australia
#17
S J Nuske, K Vernes, T W May, A W Claridge, B C Congdon, A Krockenberger, S E Abell
The data reported here support the manuscript Nuske et al. (2017) [1]. Searches were made for quantitative data on the occurrence of fungi within dietary studies of Australian mammal species. The original location reported in each study was used as the lowest grouping variable within the dataset. To standardise the data and compare dispersal events from populations of different mammal species that might overlap, data from locations were further pooled and averaged across sites if they occurred within 100 km of a random central point...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28288017/task-induced-changes-in-idiopathic-infantile-nystagmus-vary-with-gaze
#18
Marzieh Salehi Fadardi, Arne C Bathke, Solomon W Harrar, Larry Allen Abel
PURPOSE: Investigations of infantile nystagmus syndrome (INS) at center or at the null position have reported that INS worsens when visual demand is combined with internal states, e.g. stress. Visual function and INS parameters such as foveation time, frequency, amplitude, and intensity can also be influenced by gaze position. We hypothesized that increases from baseline in visual demand and mental load would affect INS parameters at the null position differently than at other gaze positions...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28237335/evaluation-of-the-14-d-cidr-pg-and-9-d-cidr-pg-protocols-for-synchronization-of-estrus-in-bos-indicus-influenced-and-bos-taurus-beef-heifers
#19
J M Thomas, J W C Locke, B E Bishop, J M Abel, M R Ellersieck, J V Yelich, S E Poock, M F Smith, D J Patterson
Two long-term, CIDR-based estrus synchronization protocols were evaluated among Bos indicus-influenced and Bos taurus beef heifers. Treatments were evaluated on the basis of estrous response and pregnancy rate resulting from fixed-time artificial insemination (FTAI), and these outcomes were analyzed retrospectively relative to reproductive tract score (RTS; Scale 1-5) at treatment initiation. Estrus was synchronized for 1139 heifers in three locations, and heifers were assigned to one of two treatments within each location based on RTS...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28222112/genome-wide-study-of-resistant-hypertension-identified-from-electronic-health-records
#20
Logan Dumitrescu, Marylyn D Ritchie, Joshua C Denny, Nihal M El Rouby, Caitrin W McDonough, Yuki Bradford, Andrea H Ramirez, Suzette J Bielinski, Melissa A Basford, High Seng Chai, Peggy Peissig, David Carrell, Jyotishman Pathak, Luke V Rasmussen, Xiaoming Wang, Jennifer A Pacheco, Abel N Kho, M Geoffrey Hayes, Martha Matsumoto, Maureen E Smith, Rongling Li, Rhonda M Cooper-DeHoff, Iftikhar J Kullo, Christopher G Chute, Rex L Chisholm, Gail P Jarvik, Eric B Larson, David Carey, Catherine A McCarty, Marc S Williams, Dan M Roden, Erwin Bottinger, Julie A Johnson, Mariza de Andrade, Dana C Crawford
Resistant hypertension is defined as high blood pressure that remains above treatment goals in spite of the concurrent use of three antihypertensive agents from different classes. Despite the important health consequences of resistant hypertension, few studies of resistant hypertension have been conducted. To perform a genome-wide association study for resistant hypertension, we defined and identified cases of resistant hypertension and hypertensives with treated, controlled hypertension among >47,500 adults residing in the US linked to electronic health records (EHRs) and genotyped as part of the electronic MEdical Records & GEnomics (eMERGE) Network...
2017: PloS One
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