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C W Abell

Jacomine E Hogewind-Schoonenboom, Lyanne W W Rövekamp-Abels, Daphne P M de Wijs-Meijler, Margaux D Maduro, Marijke C Jansen-van der Weide, Johannes B van Goudoever, Jessie M Hulst
OBJECTIVE: Early growth rates and feeding advancement rates of preterm infants are thought to influence later health. Feeding advancement is often difficult due to feeding intolerance. Exclusive human milk feeding improves tolerance, but can result in a lower weight gain rate. The addition of human milk fortifier has advantages for growth, but there are concerns that it may nullify the beneficial effect of human milk on tolerance. Therefore, the objective of this study was to evaluate the relationship between the amount of fortified human milk or formula and feeding tolerance and growth in preterm infants...
October 5, 2016: Journal of Pediatric Gastroenterology and Nutrition
Christopher C Angelakos, Adam J Watson, W Timothy O'Brien, Kyle S Krainock, Thomas Nickl-Jockschat, Ted Abel
Sleep disturbances and hyperactivity are prevalent in several neurodevelopmental disorders, including autism spectrum disorders (ASDs) and attention deficit-hyperactivity disorder (ADHD). Evidence from genome-wide association studies indicates that chromosomal copy number variations (CNVs) are associated with increased prevalence of these neurodevelopmental disorders. In particular, CNVs in chromosomal region 16p11.2 profoundly increase the risk for ASD and ADHD, disorders that are more common in males than females...
October 14, 2016: Autism Research: Official Journal of the International Society for Autism Research
Jenise C Wong, Claire Boyle, Linda A DiMeglio, Lucy D Mastrandrea, Kimber-Lee Abel, Eda Cengiz, Pinar A Cemeroglu, Grazia Aleppo, Joseph F Largay, Nicole C Foster, Roy W Beck, Saleh Adi
BACKGROUND: The objectives of this study were to examine factors associated with insulin pump discontinuation among children and adults followed longitudinally for 1 year in the multicenter T1D Exchange clinic registry, and to provide participant-reported reasons for stopping pump therapy. METHODS: We longitudinally followed 8935 participants of all ages using an insulin pump at the time of registry enrollment. Logistic regressions were used to identify demographic and clinical factors associated with pump discontinuation...
September 5, 2016: Journal of Diabetes Science and Technology
Eskouhie Tchaparian, Nancy C Sambol, Emmanuel Arinaitwe, Shelley A McCormack, Victor Bigira, Humphrey Wanzira, Mary Muhindo, Darren J Creek, Nitin Sukumar, Daniel Blessborn, Jordan W Tappero, Abel Kakuru, Yngve Bergqvist, Francesca T Aweeka, Sunil Parikh
BACKGROUND: The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children. METHODS: Capillary whole-blood lumefantrine concentration and treatment outcomes were determined in 105 Ugandan children, ages 6 months to 2 years, who were treated for 249 episodes of Plasmodium falciparum malaria with artemether-lumefantrine. RESULTS: Population pharmacokinetics for lumefantrine used a 2-compartment open model with first-order absorption...
October 15, 2016: Journal of Infectious Diseases
Donna Oksenberg, Kobina Dufu, Mira P Patel, Chihyuan Chuang, Zhe Li, Qing Xu, Abel Silva-Garcia, Chengjing Zhou, Athiwat Hutchaleelaha, Larysa Patskovska, Yury Patskovsky, Steven C Almo, Uma Sinha, Brian W Metcalf, David R Archer
A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), which leads to sickling and destruction of red blood cells (RBCs) and end-organ damage. Pharmacologically increasing the proportion of oxygenated HbS in RBCs may inhibit polymerization, prevent sickling and provide long term disease modification. We report that GBT440, a small molecule which binds to the N-terminal α chain of Hb, increases HbS affinity for oxygen, delays in vitro HbS polymerization and prevents sickling of RBCs...
October 2016: British Journal of Haematology
Ching-Ti Liu, Sridharan Raghavan, Nisa Maruthur, Edmond Kato Kabagambe, Jaeyoung Hong, Maggie C Y Ng, Marie-France Hivert, Yingchang Lu, Ping An, Amy R Bentley, Anne M Drolet, Kyle J Gaulton, Xiuqing Guo, Loren L Armstrong, Marguerite R Irvin, Man Li, Leonard Lipovich, Denis V Rybin, Kent D Taylor, Charles Agyemang, Nicholette D Palmer, Brian E Cade, Wei-Min Chen, Marco Dauriz, Joseph A C Delaney, Todd L Edwards, Daniel S Evans, Michele K Evans, Leslie A Lange, Aaron Leong, Jingmin Liu, Yongmei Liu, Uma Nayak, Sanjay R Patel, Bianca C Porneala, Laura J Rasmussen-Torvik, Marieke B Snijder, Sarah C Stallings, Toshiko Tanaka, Lisa R Yanek, Wei Zhao, Diane M Becker, Lawrence F Bielak, Mary L Biggs, Erwin P Bottinger, Donald W Bowden, Guanjie Chen, Adolfo Correa, David J Couper, Dana C Crawford, Mary Cushman, John D Eicher, Myriam Fornage, Nora Franceschini, Yi-Ping Fu, Mark O Goodarzi, Omri Gottesman, Kazuo Hara, Tamara B Harris, Richard A Jensen, Andrew D Johnson, Min A Jhun, Andrew J Karter, Margaux F Keller, Abel N Kho, Jorge R Kizer, Ronald M Krauss, Carl D Langefeld, Xiaohui Li, Jingling Liang, Simin Liu, William L Lowe, Thomas H Mosley, Kari E North, Jennifer A Pacheco, Patricia A Peyser, Alan L Patrick, Kenneth M Rice, Elizabeth Selvin, Mario Sims, Jennifer A Smith, Salman M Tajuddin, Dhananjay Vaidya, Mary P Wren, Jie Yao, Xiaofeng Zhu, Julie T Ziegler, Joseph M Zmuda, Alan B Zonderman, Aeilko H Zwinderman, Adebowale Adeyemo, Eric Boerwinkle, Luigi Ferrucci, M Geoffrey Hayes, Sharon L R Kardia, Iva Miljkovic, James S Pankow, Charles N Rotimi, Michele M Sale, Lynne E Wagenknecht, Donna K Arnett, Yii-Der Ida Chen, Michael A Nalls, Michael A Province, W H Linda Kao, David S Siscovick, Bruce M Psaty, James G Wilson, Ruth J F Loos, Josée Dupuis, Stephen S Rich, Jose C Florez, Jerome I Rotter, Andrew P Morris, James B Meigs
Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European ancestry (EA; n = 57,292), we performed trans-ethnic (AA+EA) fine-mapping of 54 established EA FG or FI loci with detailed functional annotation, assessed their relevance in AA individuals, and sought previously undescribed loci through trans-ethnic (AA+EA) meta-analysis. We narrowed credible sets of variants driving association signals for 22/54 EA-associated loci; 18/22 credible sets overlapped with active islet-specific enhancers or transcription factor (TF) binding sites, and 21/22 contained at least one TF motif...
July 7, 2016: American Journal of Human Genetics
Grant R Tremblay, J B Raymond Oonk, Françoise Combes, Philippe Salomé, Christopher P O'Dea, Stefi A Baum, G Mark Voit, Megan Donahue, Brian R McNamara, Timothy A Davis, Michael A McDonald, Alastair C Edge, Tracy E Clarke, Roberto Galván-Madrid, Malcolm N Bremer, Louise O V Edwards, Andrew C Fabian, Stephen Hamer, Yuan Li, Anaëlle Maury, Helen R Russell, Alice C Quillen, C Megan Urry, Jeremy S Sanders, Michael W Wise
Supermassive black holes in galaxy centres can grow by the accretion of gas, liberating energy that might regulate star formation on galaxy-wide scales. The nature of the gaseous fuel reservoirs that power black hole growth is nevertheless largely unconstrained by observations, and is instead routinely simplified as a smooth, spherical inflow of very hot gas. Recent theory and simulations instead predict that accretion can be dominated by a stochastic, clumpy distribution of very cold molecular clouds--a departure from the 'hot mode' accretion model--although unambiguous observational support for this prediction remains elusive...
June 9, 2016: Nature
S Riedel, S Abel, H-M Burger, L van der Westhuizen, S Swanevelder, W C A Gelderblom
Differential sensitivity of primary hepatocytes and Chang cells to the cancer promoter fumonisin B1 (FB1)-induced cytotoxic effects were investigated in relation to changes in membrane lipid distribution. In contrast to primary hepatocytes, Chang cells were resistant to FB1-induced cytotoxic effects. This was associated with a high cholesterol (Chol) and sphingomyelin (SM) and low phosphatidylcholine (PC) content, resulting in a significant (P<0.05) decrease in phosphatidylethanolamine (PE)/PC ratio, increased Chol/total phosphoglyceride (TPG) ratios and low total polyunsaturated fatty acids (PUFA) content in PC and PE, suggesting a more rigid membrane structure...
June 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Areej El-Jawahri, Tanya Keenan, Gregory A Abel, David P Steensma, Thomas W LeBlanc, Yi-Bin Chen, Gabriela Hobbs, Lara Traeger, Amir T Fathi, Daniel J DeAngelo, Martha Wadleigh, Karen K Ballen, Philip C Amrein, Richard M Stone, Jennifer S Temel
BACKGROUND: Older adults (≥60 years of age) with acute myeloid leukaemia spend a substantial proportion of their life in hospital after diagnosis. We examined reasons for their hospital admissions and identified potentially avoidable hospital admissions (PAH) in this age group in the USA. METHODS: In this retrospective analysis, we examined the reasons for hospital admissions in older patients diagnosed with and treated for acute myeloid leukaemia at two tertiary care hospitals in the USA...
June 2016: Lancet Haematology
C Abels, A Qualtieri, M De Vittorio, W M Megill, F Rizzi
To enhance today's artificial flow sensing capabilities in aerial and underwater robotics, future robots could be equipped with a large number of miniaturized sensors distributed over the surface to provide high resolution measurement of the surrounding fluid flow. In this work we show a linear array of closely separated bio-inspired micro-electro-mechanical flow sensors whose sensing mechanism is based on a piezoresistive strain-gauge along a stress-driven cantilever beam, mimicking the biological superficial neuromasts found in the lateral line organ of fishes...
June 2016: Bioinspiration & Biomimetics
Jennifer C Tudor, Emily J Davis, Lucia Peixoto, Mathieu E Wimmer, Erik van Tilborg, Alan J Park, Shane G Poplawski, Caroline W Chung, Robbert Havekes, Jiayan Huang, Evelina Gatti, Philippe Pierre, Ted Abel
Sleep deprivation is a public health epidemic that causes wide-ranging deleterious consequences, including impaired memory and cognition. Protein synthesis in hippocampal neurons promotes memory and cognition. The kinase complex mammalian target of rapamycin complex 1 (mTORC1) stimulates protein synthesis by phosphorylating and inhibiting the eukaryotic translation initiation factor 4E-binding protein 2 (4EBP2). We investigated the involvement of the mTORC1-4EBP2 axis in the molecular mechanisms mediating the cognitive deficits caused by sleep deprivation in mice...
2016: Science Signaling
Rigel J Kishton, Carson E Barnes, Amanda G Nichols, Sivan Cohen, Valerie A Gerriets, Peter J Siska, Andrew N Macintyre, Pankuri Goraksha-Hicks, Aguirre A de Cubas, Tingyu Liu, Marc O Warmoes, E Dale Abel, Allen Eng Juh Yeoh, Timothy R Gershon, W Kimryn Rathmell, Kristy L Richards, Jason W Locasale, Jeffrey C Rathmell
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic glycolysis to support proliferation, it is unclear to what extent these cell populations are metabolically similar and if differences reveal T-ALL vulnerabilities. Here we show that aerobic glycolysis is surprisingly less active in T-ALL cells than proliferating normal T cells and that T-ALL cells are metabolically distinct. Oncogenic Notch promoted glycolysis but also induced metabolic stress that activated 5' AMP-activated kinase (AMPK)...
April 12, 2016: Cell Metabolism
Eran Bacharach, Nischay Mishra, Thomas Briese, Michael C Zody, Japhette Esther Kembou Tsofack, Rachel Zamostiano, Asaf Berkowitz, James Ng, Adam Nitido, André Corvelo, Nora C Toussaint, Sandra Cathrine Abel Nielsen, Mady Hornig, Jorge Del Pozo, Toby Bloom, Hugh Ferguson, Avi Eldar, W Ian Lipkin
UNLABELLED: Tilapia are an important global food source due to their omnivorous diet, tolerance for high-density aquaculture, and relative disease resistance. Since 2009, tilapia aquaculture has been threatened by mass die-offs in farmed fish in Israel and Ecuador. Here we report evidence implicating a novel orthomyxo-like virus in these outbreaks. The tilapia lake virus (TiLV) has a 10-segment, negative-sense RNA genome. The largest segment, segment 1, contains an open reading frame with weak sequence homology to the influenza C virus PB1 subunit...
2016: MBio
Richard J Drake, Jean Addington, Ananth C Viswanathan, Shôn W Lewis, Jack Cotter, Alison R Yung, Kathryn M Abel
OBJECTIVE: Male gender and young age at onset of schizophrenia are traditionally associated with poor treatment outcome and often used to determine prognosis. However, many studies use nonincident samples and fail to adjust for symptom severity at onset. We hypothesized that age and gender would influence severity of presentation but would not predict outcome after adjustment for symptoms at presentation. METHOD: 628 people with first-episode ICD-9 and DSM-IV nonaffective psychosis from 2 historical cohorts recruited from sequential presentations in Canada and the United Kingdom (1996-1998) were assessed prospectively at presentation and over 12-18 months using the Positive and Negative Syndrome Scale (PANSS)...
March 2016: Journal of Clinical Psychiatry
Holly Dykstra, Adam Davey, Jennifer O Fisher, Heather Polonsky, Sandra Sherman, Michelle L Abel, Lauren C Dale, Gary D Foster, Katherine W Bauer
BACKGROUND: Universal access to the School Breakfast Program (SBP) is intended to help low-income and food-insecure students overcome barriers to eating breakfast. However, SBP participation is often still low despite universal access. Further information is needed with regard to these children's breakfast behaviors, and in particular breakfast behaviors among youth from food-insecure families, to inform effective breakfast interventions. OBJECTIVES: The objective of this study was to examine breakfast behaviors among a large sample of urban students with universal access to the SBP and to identify differences in breakfast behaviors among children from food-secure compared with food-insecure households...
March 2016: Journal of Nutrition
Hans Ter Steege, Nigel C A Pitman, Timothy J Killeen, William F Laurance, Carlos A Peres, Juan Ernesto Guevara, Rafael P Salomão, Carolina V Castilho, Iêda Leão Amaral, Francisca Dionízia de Almeida Matos, Luiz de Souza Coelho, William E Magnusson, Oliver L Phillips, Diogenes de Andrade Lima Filho, Marcelo de Jesus Veiga Carim, Mariana Victória Irume, Maria Pires Martins, Jean-François Molino, Daniel Sabatier, Florian Wittmann, Dairon Cárdenas López, José Renan da Silva Guimarães, Abel Monteagudo Mendoza, Percy Núñez Vargas, Angelo Gilberto Manzatto, Neidiane Farias Costa Reis, John Terborgh, Katia Regina Casula, Juan Carlos Montero, Ted R Feldpausch, Euridice N Honorio Coronado, Alvaro Javier Duque Montoya, Charles Eugene Zartman, Bonifacio Mostacedo, Rodolfo Vasquez, Rafael L Assis, Marcelo Brilhante Medeiros, Marcelo Fragomeni Simon, Ana Andrade, José Luís Camargo, Susan G W Laurance, Henrique Eduardo Mendonça Nascimento, Beatriz S Marimon, Ben-Hur Marimon, Flávia Costa, Natalia Targhetta, Ima Célia Guimarães Vieira, Roel Brienen, Hernán Castellanos, Joost F Duivenvoorden, Hugo F Mogollón, Maria Teresa Fernandez Piedade, Gerardo A Aymard C, James A Comiskey, Gabriel Damasco, Nállarett Dávila, Roosevelt García-Villacorta, Pablo Roberto Stevenson Diaz, Alberto Vincentini, Thaise Emilio, Carolina Levis, Juliana Schietti, Priscila Souza, Alfonso Alonso, Francisco Dallmeier, Leandro Valle Ferreira, David Neill, Alejandro Araujo-Murakami, Luzmila Arroyo, Fernanda Antunes Carvalho, Fernanda Coelho Souza, Dário Dantas do Amaral, Rogerio Gribel, Bruno Garcia Luize, Marcelo Petrati Pansonato, Eduardo Venticinque, Paul Fine, Marisol Toledo, Chris Baraloto, Carlos Cerón, Julien Engel, Terry W Henkel, Eliana M Jimenez, Paul Maas, Maria Cristina Peñuela Mora, Pascal Petronelli, Juan David Cardenas Revilla, Marcos Silveira, Juliana Stropp, Raquel Thomas-Caesar, Tim R Baker, Doug Daly, Marcos Ríos Paredes, Naara Ferreira da Silva, Alfredo Fuentes, Peter Møller Jørgensen, Jochen Schöngart, Miles R Silman, Nicolás Castaño Arboleda, Bruno Barçante Ladvocat Cintra, Fernando Cornejo Valverde, Anthony Di Fiore, Juan Fernando Phillips, Tinde R van Andel, Patricio von Hildebrand, Edelcilio Marques Barbosa, Luiz Carlos de Matos Bonates, Deborah de Castro, Emanuelle de Sousa Farias, Therany Gonzales, Jean-Louis Guillaumet, Bruce Hoffman, Yadvinder Malhi, Ires Paula de Andrade Miranda, Adriana Prieto, Agustín Rudas, Ademir R Ruschell, Natalino Silva, César I A Vela, Vincent A Vos, Eglée L Zent, Stanford Zent, Angela Cano, Marcelo Trindade Nascimento, Alexandre A Oliveira, Hirma Ramirez-Angulo, José Ferreira Ramos, Rodrigo Sierra, Milton Tirado, Maria Natalia Umaña Medina, Geertje van der Heijden, Emilio Vilanova Torre, Corine Vriesendorp, Ophelia Wang, Kenneth R Young, Claudia Baider, Henrik Balslev, Natalia de Castro, William Farfan-Rios, Cid Ferreira, Casimiro Mendoza, Italo Mesones, Armando Torres-Lezama, Ligia Estela Urrego Giraldo, Daniel Villarroel, Roderick Zagt, Miguel N Alexiades, Karina Garcia-Cabrera, Lionel Hernandez, Isau Huamantupa-Chuquimaco, William Milliken, Walter Palacios Cuenca, Susamar Pansini, Daniela Pauletto, Freddy Ramirez Arevalo, Adeilza Felipe Sampaio, Elvis H Valderrama Sandoval, Luis Valenzuela Gamarra
Estimates of extinction risk for Amazonian plant and animal species are rare and not often incorporated into land-use policy and conservation planning. We overlay spatial distribution models with historical and projected deforestation to show that at least 36% and up to 57% of all Amazonian tree species are likely to qualify as globally threatened under International Union for Conservation of Nature (IUCN) Red List criteria. If confirmed, these results would increase the number of threatened plant species on Earth by 22%...
November 2015: Science Advances
Laura D Hover, Philip Owens, Alexander L Munden, Jialiang Wang, Lola B Chambless, Corey R Hopkins, Charles C Hong, Harold L Moses, Ty W Abel
BACKGROUND: Improved therapies for high-grade glioma (HGG) are urgently needed as the median survival for grade IV gliomas is only 15 months. Bone morphogenetic protein (BMP) signaling plays critical and complex roles in many types of cancer, including glioma, with most of the recently published work focusing on BMP-mediated regulation of glioma stem cells (GSCs). We hypothesized that BMP signaling may be an important modulator of tumorigenic properties in glioma cells outside of the GSC compartment...
July 2016: Neuro-oncology
Grant W Mallory, Grigoriy Arutyunyan, Meghan E Murphy, Kathryn M Van Abel, Elvis Francois, Nicholas M Wetjen, Jeremy L Fogelson, Erin K O'Brien, Michelle J Clarke, Laurence J Eckel, Jamie J Van Gompel
OBJECT: Endoscopic approaches to the anterior craniocervical junction are increasing in frequency. Choice of oral versus endoscopic endonasal approach to the odontoid often depends on the relationship of the C1-2 complex to the hard palate. However, it is not known how this relevant anatomy changes with age. We hypothesize that there is a dynamic relationship of C-2 and the hard palate, which changes with age, and potentially affects the choice of surgical approach. The aim of this study was to characterize the relationship of C-2 relative to the hard palate with respect to age and sex...
April 2016: Journal of Neurosurgery. Spine
Thomas Abel, Brendan Burkett, Barbara Thees, Stefan Schneider, Christopher D Askew, Heiko K Strüder
INTRODUCTION: Handcycling is a relatively new wheelchair sport that has gained increased popularity for people with lower limb disabilities. The aim of this study was to examine the effect of three different grip positions on physical parameters during handcycling in a laboratory setting. METHODS: Twenty one able-bodied participants performed three maximum incremental handcycling tests until exhaustion, each with a different grip angle. The angle between the grip and the crank was randomly set at 90° (horizontal), 0° (vertical), or 10° (diagonal)...
2015: Frontiers in Physiology
Lyanne W W Rövekamp-Abels, Jacomine E Hogewind-Schoonenboom, Daphne P M de Wijs-Meijler, Margaux D Maduro, Marijke C Jansen-van der Weide, Johannes B van Goudoever, Jessie M Hulst
OBJECTIVES: The aim of the present study was to assess the clinical benefits and risks of semicontinuous (CON) versus intermittent nasogastric tube feeding in low-birth-weight infants. METHODS: Infants with a birth weight <1750 g and gestational age <32 weeks were stratified according to birth weight and assigned to either CON or intermittent bolus (BOL) feeding. The primary endpoint was days to full enteral feeding (defined as 120 mL(-1) · kg(-1) · day(-1))...
December 2015: Journal of Pediatric Gastroenterology and Nutrition
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