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Hospital Viedma

Laura Pérez-Lago, Miguel Martínez-Lirola, Sergio García, Marta Herranz, Igor Mokrousov, Iñaki Comas, Llúcia Martínez, Emilio Bouza, Darío García de Viedma
Current migratory movements require new strategies for rapid tracking of the transmission of high-risk imported Mycobacterium tuberculosis strains. Whole genome sequencing (WGS) enables us to identify single-nucleotide polymorphisms (SNPs) and therefore design polymerase-chain-reaction assays (PCRs) to track specific relevant strains. However, fast implementation of these strategies in the hospital setting is difficult because professionals working in diagnostics, molecular epidemiology, and genomics are generally in separate institutions...
September 28, 2016: Journal of Clinical Microbiology
Domingo Palacios-Ceña, Blanca Talavera, Pedro López-Ruiz, Álvaro Gutiérrez-Viedma, María Palacios-Ceña, José A Arias, César Fernández-de-Las-Peñas, María L Cuadrado
OBJECTIVE: Our aim was to explore the views and experiences of a group of Spanish men suffering from cluster headache (CH). BACKGROUND: CH has considerable effects on patients' quality of life, impairs everyday activities, and can modify lifestyle. This is the first time the experience of patients with CH is examined in a clinical study using a qualitative, phenomenological approach. METHODS: We conducted a qualitative phenomenological study exploring how 20 male patients with CH, followed at the Headache Unit of a Spanish hospital, perceived their disease...
July 2016: Headache
María L Cuadrado, Ángel Aledo-Serrano, Pedro López-Ruiz, Álvaro Gutiérrez-Viedma, Cristina Fernández, Aida Orviz, José A Arias
BACKGROUND: Presently, there is no evidence to guide the acute treatment of migraine aura. We aimed to describe the effect of greater occipital nerve (GON) anaesthetic block as a symptomatic treatment for long-lasting (prolonged or persistent) migraine aura. METHODS: Patients who presented with migraine aura lasting > 2 hours were consecutively recruited during one year at the Headache Unit and the Emergency Department of a tertiary hospital. All patients underwent a bilateral GON block with bupivacaine 0...
June 10, 2016: Cephalalgia: An International Journal of Headache
Javier Casas-Limón, María L Cuadrado, Marina Ruiz, Elena Martínez, Álvaro Gutiérrez-Viedma, Carlos M Ordás, Ángel L Guerrero
OBJECTIVE: We aim to report 4 patients with brief pain paroxysms whose clinical features remind of typical epicrania fugax (EF), except for the direction along a transverse trajectory. BACKGROUND: EF has been defined as a brief paroxysmal head pain, with stabbing quality, describing a linear or zig-zag trajectory across the surface of one hemicranium. METHODS: We considered all patients attending the headache outpatient office at 3 tertiary hospitals from March 2008 to December 2015...
June 2016: Headache
Marcela González-Del Vecchio, María Jesús Ruíz-Serrano, Paloma Gijón, Mar Sánchez-Somolinos, Viviana de Egea, Darío García de Viedma, María Norberta Sánchez Fresneda, Emilio Bouza
BACKGROUND: Intravesical instillation of Bacillus Calmette-Guérin (BCG) is an efficient immunotherapy for superficial bladder cancer. BCG infection represents a major yet uncommon adverse event that occurs in 5-10% of the patients treated with BCG instillations, though the pathogenesis of this entity is not clear. METHODS: We report two cases of patients presented at our institution with BCG infection after instillation: one with microbiological BCG isolate and another without, and review all the medical records of patients instilled with BCG in our institution from 1996 until 2012, comparing patients with probable and proven BCG infection...
July 2016: Diagnostic Microbiology and Infectious Disease
Eduardo Albéniz, María Fraile, Berta Ibáñez, Pedro Alonso-Aguirre, David Martínez-Ares, Santiago Soto, Carla Jerusalén Gargallo, Felipe Ramos Zabala, Marco Antonio Álvarez, Joaquín Rodríguez-Sánchez, Fernando Múgica, Óscar Nogales, Alberto Herreros de Tejada, Eduardo Redondo, Carlos Guarner-Argente, Noel Pin, Helena León-Brito, Remedios Pardeiro, Leopoldo López-Roses, Manuel Rodríguez-Téllez, Alejandra Jiménez, Felipe Martínez-Alcalá, Orlando García, Joaquín de la Peña, Akiko Ono, Fernando Alberca de Las Parras, María Pellisé, Liseth Rivero, Esteban Saperas, Francisco Pérez-Roldán, Antonio Pueyo Royo, Javier Eguaras Ros, Alba Zúñiga Ripa, Mar Concepción-Martín, Patricia Huelin-Álvarez, Juan Colán-Hernández, Joaquín Cubiella, David Remedios, Xavier Bessa I Caserras, Bartolomé López-Viedma, Julyssa Cobian, Mariano González-Haba, José Santiago, Juan Gabriel Martínez-Cara, Eduardo Valdivielso
BACKGROUND & AIMS: After endoscopic mucosal resection (EMR) of colorectal lesions, delayed bleeding is the most common serious complication, but there are no guidelines for its prevention. We aimed to identify risk factors associated with delayed bleeding that required medical attention after discharge until day 15 and develop a scoring system to identify patients at risk. METHODS: We performed a prospective study of 1214 consecutive patients with nonpedunculated colorectal lesions 20 mm or larger treated by EMR (n = 1255) at 23 hospitals in Spain, from February 2013 through February 2015...
August 2016: Clinical Gastroenterology and Hepatology
Patricia Brañas, Jennifer Villa, Esther Viedma, Jesús Mingorance, M Angeles Orellana, Fernando Chaves
Here we report a retrospective clinical and molecular study conducted in a tertiary care facility in southern Madrid, Spain, from January 2009 to February 2014 to investigate the epidemiology of carbapenemase-producing Klebsiella pneumoniae (CPKp). Carbapenemase genes were identified in 97 non-duplicate K. pneumoniae isolates, including 59 harbouring blaOXA-48, 37 harbouring blaVIM-1 and 1 harbouring blaKPC-2. Pulsed-field gel electrophoresis (PFGE) analysis verified the presence of 20 different clonal types, whilst multilocus sequence typing (MLST) assigned the isolates to eight sequence types (STs)...
July 2015: International Journal of Antimicrobial Agents
Esther Viedma, Jenifer Villa, Carlos Juan, Antonio Oliver, Fernando Chaves
We report the genome of colistin-only-susceptible Pseudomonas aeruginosa strain ST235 (PA_ST235). This isolate was obtained in the setting of an outbreak in a tertiary hospital in Spain. This clone was apparently associated with a significantly higher mortality rate. The ST235 clone also appears to be associated with greater virulence.
2014: Genome Announcements
Jennifer Villa, Esther Viedma, Patricia Brañas, Jesús Mingorance, Fernando Chaves
We present the draft genome sequence of a blood culture isolate of OXA-48-producing Klebsiella pneumoniae (sequence type 11 [ST11]) obtained in the course of a hospital outbreak in Spain. Sequence analysis showed 121 genes related to antibiotic and antiseptic resistance, including blaOXA-48, which was located in an IncL/M plasmid.
2014: Genome Announcements
Jennifer Villa, Esther Viedma, Patricia Brañas, M Angeles Orellana, Joaquín R Otero, Fernando Chaves
Over a 6-year period (2007-2012), the emergence of Enterobacter cloacae isolates resistant to β-lactams and with reduced susceptibility to carbapenems was observed in Hospital Universitario 12 de Octubre (Madrid, Spain). To determine the possible role of metallo-β-lactamases (MBLs) in the resistance profile of these isolates, a molecular and clinical epidemiological study was performed, including determination of patients' clinical characteristics, genetic diversity of strains, resistance mechanisms to carbapenems, and the genetic environment of VIM-1...
May 2014: International Journal of Antimicrobial Agents
Maribel Botana Rial, Andrés Briones Gómez, José Ramón Ferrando Gabarda, José Fernando Cifuentes Ruiz, María Juliana Guarín Corredor, Nuria Manchego Frach, Enrique Cases Viedma
INTRODUCTION AND OBJECTIVES: The evaluation of pleural effusion (PE) includes various techniques, including pleural biopsy (PB). Our aim was to study the diagnostic yield of Tru-Cut needle PB (TCPB) and to define clinical/radiological situations in which TCPB might be indicated as an initial procedure. METHODOLOGY: Retrospective study of TCPB in a hospital centre (2010-2012). Cases of pleural lesions without effusion were excluded. Clinical and radiological variables, diagnostic yield, TCPB complications and factors associated with the diagnostic yield of the combination of TCPB and thoracocentesis as initial procedure were analysed...
August 2014: Archivos de Bronconeumología
Esther Viedma, Vanesa Estepa, Carlos Juan, Jane Castillo-Vera, Beatriz Rojo-Bezares, Cristina Seral, Francisco Javier Castillo, Yolanda Sáenz, Carmen Torres, Fernando Chaves, Antonio Oliver
Twenty-seven well-characterized metallo-β-lactamase (MBL)-producing Pseudomonas strains from two distantly located hospitals were analyzed. The results revealed specific features defining the multilevel epidemiology of strains from each hospital in terms of species, clonality, predominance of high-risk clones, composition/diversity of integrons, and linkages of Tn402-related structures. Therefore, despite the global trends driving the epidemiology of MBL-producing Pseudomonas spp., the presence of local features has to be considered in order to understand this threat and implement proper control strategies...
2014: Antimicrobial Agents and Chemotherapy
Eleonora Bunsow, María Jesús Ruiz-Serrano, Paula López Roa, Martha Kestler, Dario Garcia Viedma, Emilio Bouza
OBJECTIVES: GeneXpert (GX) is a novel real-time polymerase chain reaction assay for the simultaneous detection of Mycobacterium tuberculosis (MTB) and resistance to rifampin (RIF). We evaluated the performance of GX for direct detection of MTB in respiratory and non-respiratory specimens and assessed the ability of the assay to detect resistance to RIF in non-tuberculosis (TB) endemic country. METHODS: We analyzed 595 clinical samples in a 1550-bed tertiary hospital in Madrid, Spain...
April 2014: Journal of Infection
Esther Viedma, Francisca Sanz, M Angeles Orellana, Rafael San Juan, Jose Maria Aguado, Joaquín R Otero, Fernando Chaves
OBJECTIVES: Limited data exist regarding the role of agr dysfunction in reducing susceptibility to vancomycin in methicillin-susceptible Staphylococcus aureus (MSSA). This study investigated the clinical and molecular epidemiology of MSSA causing bacteraemia, with emphasis on the reduced susceptibility to vancomycin (RSV) phenotype (MIC ≥ 1.5 mg/L) and its relationship with agr dysfunction. METHODS: All MSSA bloodstream isolates obtained at our hospital during 2010 were analysed...
January 2014: Journal of Antimicrobial Chemotherapy
Esther Viedma, Carlos Juan, Joaquín R Otero, Antonio Oliver, Fernando Chaves
The VIM-2-producing multidrug-resistant high-risk clone Pseudomonas aeruginosa sequence type (ST) 175 was isolated in the setting of a large outbreak in Hospital Universitario 12 de Octubre (Spain) from 2007 to 2010. This strain was resistant to all β-lactams, fluoroquinolones, and aminoglycosides, with the exception of amikacin, and has become an endemic clone in our institution.
March 2013: Genome Announcements
Esther Viedma, Carlos Juan, Jennifer Villa, Laura Barrado, M Angeles Orellana, Francisca Sanz, Joaquín R Otero, Antonio Oliver, Fernando Chaves
A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010...
August 2012: Emerging Infectious Diseases
Maddalena Giannella, Belen Rodríguez-Sánchez, Paula López Roa, Pilar Catalán, Patricia Muñoz, Darío García de Viedma, Emilio Bouza
INTRODUCTION: Influenza is easily overlooked in intensive care units (ICUs), particularly in patients with alternative causes of respiratory failure or in those who acquire influenza during their ICU stay. METHODS: We performed a prospective study of patients admitted to three adult ICUs of our hospital from December 2010 to February 2011. All tracheal aspirate (TA) samples sent to the microbiology department were systematically screened for influenza. We defined influenza as unsuspected if testing was not requested and the patient was not receiving empirical antiviral therapy after sample collection...
2012: Critical Care: the Official Journal of the Critical Care Forum
J Ledesma, P Muñoz, D Garcia de Viedma, I Cabrero, B Loeches, P Montilla, P Gijon, B Rodriguez-Sanchez, E Bouza
The aim of this study is to evaluate the prevalence of BK virus (BKV) infection in HIV-positive patients receiving highly active antiretroviral therapy (HAART) in our hospital. The presence of BKV was analysed in urine and plasma samples from 78 non-selected HIV-infected patients. Clinical data were recorded using a pre-established protocol. We used a nested PCR to amplify a specific region of the BKV T-large antigen. Positive samples were quantified using real-time PCR. Mean CD4 count in HIV-infected patients was 472 cells/mm3 and median HIV viral load was <50 copies/mL...
July 2012: European Journal of Clinical Microbiology & Infectious Diseases
Jesús Guinea, Darío García de Viedma, Teresa Peláez, Pilar Escribano, Patricia Muñoz, Jacques F Meis, Corné H W Klaassen, Emilio Bouza
We recently reported an outbreak of invasive aspergillosis in the major heart surgery unit of Hospital Gregorio Marañón, Madrid, Spain (T. Peláez, P. Muñoz, J. Guinea, M. Valerio, M. Giannella, C. H. W. Klaassen, and E. Bouza, Clin. Infect. Dis., in press). Aspergillus fumigatus was isolated from clinical samples from 10 patients admitted to the unit during the outbreak period (surgical wound invasive aspergillosis, n = 2; probable pulmonary invasive aspergillosis, n = 4; colonization, n = 4). In the study described here, we have studied the genotypic diversity of the A...
October 2011: Journal of Clinical Microbiology
B Rodríguez-Sánchez, M Alonso, P Catalán, M Sánchez Conde, F González-Candelas, M Giannella, E Bouza, D García de Viedma
BACKGROUND: Epidemiological surveys have revealed outbreaks of pandemic influenza A (H1N1) 2009 in several different contexts. Molecular characterization of the influenza virus could help to provide a more accurate description of these outbreaks. OBJECTIVE: To genotype pandemic influenza A (H1N1) 2009 isolates from an epidemiologically defined nosocomial outbreak. STUDY DESIGN: We sequenced the neuraminidase (NA) and hemagglutinin (HA) influenza A (H1N1) 2009 genes from ten HIV-positive patients involved in an epidemiologically defined outbreak in the Clinical Microbiology and Infectious Diseases (CMID) Department...
October 2011: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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