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Idiopathic normal pressure hydrocephalus

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https://www.readbyqxmd.com/read/28448824/a-new-quantitative-method-to-assess-disproportionately-enlarged-subarachnoid-space-desh-in-patients-with-possible-idiopathic-normal-pressure-hydrocephalus-the-silver-index
#1
Nicola Benedetto, Carlo Gambacciani, Filippo Aquila, Davide Tiziano Di Carlo, Riccardo Morganti, Paolo Perrini
OBJECTIVES: Preoperative diagnosis of idiopathic normal-pressure hydrocephalus (iNPH) remains challenging. Recently, the presence of disproportionally enlarged subarachnoid spaces and hydrocephalus (DESH) on diagnostic images has been linked to clinical improvement after ventriculoperitoneal (VP) shunt placement. In this study we describe a new quantitative method to assess DESH on CT scans and to evaluate its prognostic value. PATIENTS AND METHODS: A multiplanar reconstruction software was used to retrospectively evaluate prospectively collected radiological data (CT scans) of 26 controls and 29 consecutive patients that underwent VP shunt placement for possible iNPH...
April 19, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28421283/shunting-of-the-over-80s-in-normal-pressure-hydrocephalus
#2
Simon D Thompson, J D Shand Smith, A A Khan, A M V Luoma, A K Toma, L D Watkins
BACKGROUND: Idiopathic normal pressure hydrocephalus is predominantly a disease of the elderly. By its nature, many of those who present to clinic are in advanced old age with multiple comorbidities. Majority of patients treated are younger than 80 years old. We present the clinical outcomes and complication rates of patients over the age of 80 years at the time of operation, during the past 11 years at a single institution. METHODS: Retrospective analysis of clinical records of all patients over the age of 80 years, who presented to our institution between 2006 and 2016...
April 18, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28420385/frontotemporal-dementia-as-a-comorbidity-to-idiopathic-normal-pressure-hydrocephalus-inph-a-short-review-of-literature-and-an-unusual-case
#3
REVIEW
V E Korhonen, E Solje, N M Suhonen, T Rauramaa, R Vanninen, A M Remes, V Leinonen
Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can present with similar symptoms. These include decline in executive functions, psychomotor slowness, and behavioural and personality changes. Ventricular enlargement is a key radiological finding in iNPH that may also be present in bvFTD caused by the C9ORF72 expansion mutation. Due to this, bvFTD has been hypothesized as a potential comorbidity to iNPH but bvFTD patients have never been identified in studies focusing in clinical comorbidities with iNPH...
April 19, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28378775/evidence-of-an-application-of-a-variable-mems-capacitive-sensor-for-detecting-shunt-occlusions
#4
David J Apigo, Philip L Bartholomew, Thomas Russell, Alokik Kanwal, Reginald C Farrow, Gordon A Thomas
A sensor was tested subdural and in vitro, simulating a supine infant with a ventricular-peritoneal shunt and controlled occlusions. The variable MEMS capacitive device is able to detect and forecast blockages, similar to early detection procedures in cancer patients. For example, with gradual occlusion development over a year, the method forecasts a danger over one month ahead of blockage. The method also distinguishes between ventricular and peritoneal occlusions. Because the sensor provides quantitative data on the dynamics of the cerebrospinal fluid, it can help test new therapies and work toward understanding hydrocephalus as well as idiopathic normal pressure hydrocephalus...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28348958/diffusion-imaging-of-reversible-and-irreversible-microstructural-changes-within-the-corticospinal-tract-in-idiopathic-normal-pressure-hydrocephalus
#5
Kouhei Kamiya, Masaaki Hori, Ryusuke Irie, Masakazu Miyajima, Madoka Nakajima, Koji Kamagata, Kouhei Tsuruta, Asami Saito, Misaki Nakazawa, Yuichi Suzuki, Harushi Mori, Akira Kunimatsu, Hajime Arai, Shigeki Aoki, Osamu Abe
The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt surgery, but prediction of treatment outcome is not established. We investigated changes of the corticospinal tract (CST) in iNPH before and after shunt surgery by using diffusion microstructural imaging, which infers more specific tissue properties than conventional diffusion tensor imaging. Two biophysical models were used: neurite orientation dispersion and density imaging (NODDI) and white matter tract integrity (WMTI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28347957/ventriculoatrial-versus-ventriculoperitoneal-shunt-complications-in-idiopathic-normal-pressure-hydrocephalus
#6
Alice L Hung, Tito Vivas-Buitrago, Atif Adam, Jennifer Lu, Jamie Robison, Benjamin D Elder, C Rory Goodwin, Ignacio Jusué-Torres, Daniele Rigamonti
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a devastating condition that affects the elderly population. Although ventriculoatrial (VA) shunts can be used to manage iNPH, concerns for associated cardiopulmonary and renal complications have decreased their use. However, the rate of these complications is not well understood within this population of patients. PATIENTS AND METHODS: A retrospective review of the electronic medical records of patients diagnosed with iNPH by the senior author between 1993 and 2015 was performed...
March 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28339331/differential-diagnosis-of-a-patient-referred-to-physical-therapy-for-dizziness-a-case-report
#7
Zachary Rethorn, Susan J Barlow, Emily Gavlick
STUDY DESIGN: Case report. BACKGROUND: Dizziness is a common and debilitating condition across the lifespan. Patients with this complaint must be carefully examined to determine the cause of dizziness, rule out the presence of central nervous system dysfunction, and determine the appropriateness of physical therapy intervention. CASE DESCRIPTION: A 90-year-old male was referred to physical therapy six months after the onset of dizziness. A thorough history was taken and examination was performed...
March 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28293475/nationwide-hospital-based-survey-of-idiopathic-normal-pressure-hydrocephalus-in-japan-epidemiological-and-clinical-characteristics
#8
Nagato Kuriyama, Masakazu Miyajima, Madoka Nakajima, Michiko Kurosawa, Wakaba Fukushima, Yoshiyuki Watanabe, Etsuko Ozaki, Yoshio Hirota, Akiko Tamakoshi, Etsuro Mori, Takeo Kato, Takahiko Tokuda, Akinori Urae, Hajime Arai
OBJECTIVES: There have been no nationwide epidemiological studies of idiopathic normal pressure hydrocephalus (iNPH) in Japan. Therefore, a nationwide epidemiologic survey of iNPH was performed to determine the number of cases and clinical characteristics by sex and diagnostic level. METHODS: The first survey examined the numbers of cases that met the diagnostic criteria of iNPH and those who underwent shunt operations in 2012. The second survey gathered patients' details to clarify their clinical background characteristics...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28259041/trunk-sway-in-idiopathic-normal-pressure-hydrocephalus-quantitative-assessment-in-clinical-practice
#9
Tomas Bäcklund, Jennifer Frankel, Hanna Israelsson, Jan Malm, Nina Sundström
BACKGROUND: In diagnosis and treatment of patients with idiopathic normal pressure hydrocephalus (iNPH), there is need for clinically applicable, quantitative assessment of balance and gait. Using a body-worn gyroscopic system, the aim of this study was to assess postural stability of iNPH patients in standing, walking and during sensory deprivation before and after cerebrospinal fluid (CSF) drainage and surgery. A comparison was performed between healthy elderly (HE) and patients with various types of hydrocephalus (ventriculomegaly (VM))...
February 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28257339/symri-of-the-brain-rapid-quantification-of-relaxation-rates-and-proton-density-with-synthetic-mri-automatic-brain-segmentation-and-myelin-measurement
#10
Akifumi Hagiwara, Marcel Warntjes, Masaaki Hori, Christina Andica, Misaki Nakazawa, Kanako Kunishima Kumamaru, Osamu Abe, Shigeki Aoki
Conventional magnetic resonance images are usually evaluated using the image signal contrast between tissues and not based on their absolute signal intensities. Quantification of tissue parameters, such as relaxation rates and proton density, would provide an absolute scale; however, these methods have mainly been performed in a research setting. The development of rapid quantification, with scan times in the order of 6 minutes for full head coverage, has provided the prerequisites for clinical use. The aim of this review article was to introduce a specific quantification method and synthesis of contrast-weighted images based on the acquired absolute values, and to present automatic segmentation of brain tissues and measurement of myelin based on the quantitative values, along with application of these techniques to various brain diseases...
March 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28251346/cost-effectiveness-analysis-of-shunt-surgery-for-idiopathic-normal-pressure-hydrocephalus-based-on-the-sinphoni-and-sinphoni-2-trials
#11
Masahiro Kameda, Shigeki Yamada, Masamichi Atsuchi, Teruo Kimura, Hiroaki Kazui, Masakazu Miyajima, Etsuro Mori, Masatsune Ishikawa, Isao Date
BACKGROUND: We showed that ventriculoperitoneal (VP) shunt and lumboperitoneal (LP) shunt surgeries are beneficial for patients with idiopathic normal pressure hydrocephalus (iNPH) in the Study of Idiopathic Normal Pressure Hydrocephalus on Neurological Improvement (SINPHONI; a multicenter prospective cohort study) and in SINPHONI-2 (a multicenter randomized trial). Although therapeutic efficacy is important, cost-effectiveness analysis is equally valuable. METHODS: Using both a set of assumptions and using the data from SINPHONI and SINPHONI-2, we estimated the total cost of treatment for iNPH, which consists of medical expenses (e...
March 1, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28247411/reversed-aqueductal-cerebrospinal-fluid-net-flow-in-idiopathic-normal-pressure-hydrocephalus
#12
L K Yin, J J Zheng, L Zhao, X Z Hao, X X Zhang, J Q Tian, K Zheng, Y M Yang
OBJECTIVES: The changes of CSF flow dynamics in idiopathic normal pressure hydrocephalus (iNPH) are not fully elucidated. Most previous studies took the whole cardiac cycle as a unit. In this work, it is divided into systole and diastole phase and compared between iNPH patients and normal elderly and paid special attention to the change of netflow direction. MATERIALS AND METHODS: Twenty iNPH patients according to international guideline and twenty healthy volunteers were included in this study and examined by MRI...
March 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28238737/mortality-and-risk-of-dementia-in-normal-pressure-hydrocephalus-a%C3%A2-population-study
#13
Daniel Jaraj, Carsten Wikkelsø, Katrin Rabiei, Thomas Marlow, Christer Jensen, Svante Östling, Ingmar Skoog
INTRODUCTION: We examined mortality, dementia, and progression of hydrocephalic symptoms among untreated individuals with idiopathic normal-pressure hydrocephalus (iNPH) in a population-based sample. METHODS: A total of 1235 persons were examined between 1986 and 2012. Shunted individuals were excluded. We examined 53 persons with hydrocephalic ventricular enlargement (probable iNPH: n = 24, asymptomatic or possible iNPH: n = 29). Comparisons were made with individuals without hydrocephalic ventricular enlargement...
February 24, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28185313/improvement-in-lower-urinary-tract-symptoms-across-multiple-domains-following-ventriculoperitoneal-shunting-for-idiopathic-normal-pressure-hydrocephalus
#14
Sarah C Krzastek, Samuel P Robinson, Harold F Young, Adam P Klausner
AIMS: The purpose of this study was to evaluate the change in lower urinary tract symptoms following ventriculoperitoneal shunting in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: Lower urinary tract symptoms in patients with new-onset iNPH were prospectively evaluated using validated questionnaires from the International Consultation on Incontinence to assess overactive bladder (ICIq-OAB), incontinence (ICIq-UI), and quality of life (ICIq-LUTqol), as well as the American Urological Association Symptom Score bother scale, prior to and following ventriculoperitoneal shunting for iNPH...
February 10, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28156249/utility-of-mri-based-disproportionately-enlarged-subarachnoid-space-hydrocephalus-scoring-for-predicting-prognosis-after-surgery-for-idiopathic-normal-pressure-hydrocephalus-clinical-research
#15
Narihide Shinoda, Osamu Hirai, Shinya Hori, Kazuyuki Mikami, Toshiaki Bando, Daisuke Shimo, Takahiro Kuroyama, Yoji Kuramoto, Masato Matsumoto, Yasushi Ueno
OBJECTIVE The presence of disproportionately enlarged subarachnoid space hydrocephalus (DESH) on brain imaging is a recognized finding of idiopathic normal pressure hydrocephalus (iNPH), but the features of DESH can vary across patients. The aim of this study was to evaluate the utility of MRI-based DESH scoring for predicting prognosis after surgery. METHODS In this single-center, retrospective cohort study, the DESH score was determined by consensus between a group of neurosurgeons, neurologists, and a neuroradiologist based on the preoperative MRI findings of the patients with suspected iNPH...
February 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28132644/a-change-in-brain-white-matter-after-shunt-surgery-in-idiopathic-normal-pressure-hydrocephalus-a-tract-based-spatial-statistics-study
#16
Shigenori Kanno, Makoto Saito, Tomohito Kashinoura, Yoshiyuki Nishio, Osamu Iizuka, Hirokazu Kikuchi, Masahito Takagi, Masaki Iwasaki, Shoki Takahashi, Etsuro Mori
BACKGROUND: The aim of this study was to elucidate changes in cerebral white matter after shunt surgery in idiopathic normal pressure hydrocephalus (INPH) using diffusion tensor imaging (DTI). METHODS: Twenty-eight consecutive INPH patients whose symptoms were followed for 1 year after shunt placement and 10 healthy control (HC) subjects were enrolled. Twenty of the initial 28 INPH patients were shunt-responsive (SR) and the other 8 patients were non-responsive (SNR)...
January 30, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28120085/neuropsychological-assessment-in-the-differential-diagnosis-of-idiopathic-normal-pressure-hydrocephalus-an-important-tool-for-the-maintenance-and-restoration-of-neuronal-and-neuropsychological-functions
#17
Carmela Sindorio, Rosaria Viola Abbritti, Giovanni Raffa, Stefano M Priola, Antonino Germanò, Massimiliano Visocchi, Maria C Quattropani
Idiopathic normal pressure hydrocephalus (iNPH) is a progressive clinical syndrome that includes gait disturbances, urinary incontinence, and cognitive impairment. iNPH shows similarities to other neurodegenerative disorders, primarily Alzheimer's Disease (AD). Definition of the neuropsychological profile of iNPH and the qualitative analysis of systematic mistakes made in cognitive tests could represent a valid method for systematizing possible specific markers of iNPH dementia and differentiating it from other dementias...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28089835/supplementary-tests-in-idiopathic-normal-pressure-hydrocephalus-a-single-center-experience-with-a-combined-lumbar-infusion-test-and-tap-test
#18
Fabio Raneri, Maria Angela Samis Zella, Andrea Di Cristofori, Barbara Zarino, Mauro Pluderi, Diego Spagnoli
BACKGROUND: The lumbar infusion test (LIT) and tap test (TT) have previously been described for the diagnosis and selection of appropriate surgical candidates in idiopathic normal pressure hydrocephalus (iNPH). METHODS: We retrospectively reviewed 81 consecutive patients with a clinical diagnosis of iNPH selected for supplementary testing. Clinical evaluation was scored with the Japanese Grading Scale for Normal Pressure Hydrocephalus, the Global Deterioration Score, and the modified Rankin Scale (mRS)...
April 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28063896/clinical-correlation-of-abnormal-findings-on-magnetic-resonance-elastography-in-idiopathic-normal-pressure-hydrocephalus
#19
Avital Perry, Christopher S Graffeo, Nikoo Fattahi, Mona M ElSheikh, Nealey Cray, Arvin Arani, Richard L Ehman, Kevin J Glaser, Armando Manduca, Fredric B Meyer, John Huston
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a ventriculomegaly syndrome characterized by dementia, urinary incontinence, and gait disturbance, which is potentially reversible after ventriculoperitoneal shunting (VPS). Magnetic resonance elastography (MRE) is an evolving imaging technology that noninvasively measures tissue viscoelasticity. We studied iNPH patients using MRE prior to shunting, compared them with normal controls, and analyzed associations between MRE findings and clinical features, as a pilot assessment of MRE in iNPH...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28062721/vascular-risk-factors-in-inph-a-prospective-case-control-study-the-inph-crash-study
#20
Hanna Israelsson, Bo Carlberg, Carsten Wikkelsö, Katarina Laurell, Babar Kahlon, Göran Leijon, Anders Eklund, Jan Malm
OBJECTIVE: To assess the complete vascular risk factor (VRF) profile of idiopathic normal pressure hydrocephalus (INPH) using a large sample of representative patients with INPH and population-based controls to determine the extent to which vascular disease influences INPH pathophysiology. METHODS: All patients with INPH who underwent shunting in Sweden in 2008-2010 were compared to age- and sex-matched population-based controls. Inclusion criteria were age 60-85 years and no dementia...
February 7, 2017: Neurology
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