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Idiopathic normal pressure hydrocephalus

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https://www.readbyqxmd.com/read/28904452/long-term-response-of-cerebrospinal-fluid-pressure-in-patients-with-idiopathic-intracranial-hypertension-a-prospective-observational-study
#1
V Abdul Gafoor, B Smita, James Jose
BACKGROUND: Idiopathic intracranial hypertension (IIH) is increased intracranial pressure (ICP) with normal cerebrospinal fluid (CSF) contents, in the absence of an intracranial mass, hydrocephalus, or other identifiable causes. The current knowledge of the treatment outcome of IIH is limited, and the data on the natural history of this entity are scant. OBJECTIVE: The objective of the study is to study the treatment response of IIH by serially measuring the CSF opening pressure and to delineate the factors influencing the same...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28899431/the-role-of-perfusion-and-diffusion-mri-in-the-assessment-of-patients-affected-by-probable-idiopathic-normal-pressure-hydrocephalus-a-cohort-prospective-preliminary-study
#2
Francesco Tuniz, Maria Caterina Vescovi, Daniele Bagatto, Daniela Drigo, Maria Cristina De Colle, Marta Maieron, Miran Skrap
BACKGROUND: Invasive tests measuring resistance to cerebral spinal fluid (CSF) outflow and the effect of temporary drainage of CSF are used to select candidates affected by idiopathic normal pressure hydrocephalus (iNPH) for shunt surgery. Neither test, however, completely excludes patients from treatment. Perfusion and diffusion magnetic resonance imaging (MRI) are non-invasive techniques that might be of value in selecting patients for surgical treatment and understanding brain changes in iNPH patients...
September 12, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28892572/deconstructing-normal-pressure-hydrocephalus-ventriculomegaly-as-early-sign-of-neurodegeneration
#3
REVIEW
Alberto J Espay, Gustavo A Da Prat, Alok K Dwivedi, Federico Rodriguez-Porcel, Jennifer E Vaughan, Michela Rosso, Johnna L Devoto, Andrew P Duker, Mario Masellis, Charles D Smith, J George T Mandybur, Aristide Merola, Anthony E Lang
Idiopathic normal pressure hydrocephalus (NPH) remains both over-suspected on clinical grounds and under-confirmed when based on immediate and sustained response to cerebrospinal fluid diversion. Poor long-term post-shunt benefits and findings of neurodegenerative pathology in most patients with adequate follow up suggests that hydrocephalic disorders appearing in late adulthood may often result from initially unapparent parenchymal abnormalities. We critically review the NPH literature, highlighting the near universal lack of blinding and controls, the absence of specific clinical, imaging, or pathologic features, and the ongoing dependence for diagnostic confirmation on variable cutoffs of gait response to bedside fluid-drainage testing...
September 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28892272/effect-of-cerebrospinal-fluid-shunt-surgery-on-lower-urinary-tract-dysfunction-in-idiopathic-normal-pressure-hydrocephalus
#4
Seiji Aruga, Nobumasa Kuwana, Yoshiharu Shiroki, Shintaro Takahashi, Naoyuki Samejima, Akira Watanabe, Yojiro Seki, Yasuhiko Igawa, Yukio Homma
AIMS: To examine the outcomes of lower urinary tract symptoms (LUTS) and urodynamic test results after cerebrospinal fluid (CSF) shunt surgery in idiopathic normal pressure hydrocephalus (iNPH). METHODS: Records of 48 patients (33 men; 15 women), who met the definite iNPH criteria and underwent CSF shunt surgery, were retrospectively analyzed. LUTS and their impact on quality of life (QOL) were evaluated using an all-or-none questionnaire targeting four symptoms, the Overactive Bladder Symptoms Score (OABSS), and the QOL index...
September 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28889317/the-predictive-value-of-t-tau-and-ab1-42-levels-in-idiopathic-normal-pressure-hydrocephalus
#5
Claudia L Craven, Irene Baudracco, Henrik Zetterberg, Michael P T Lunn, Miles D Chapman, Neghat Lakdawala, Laurence D Watkins, Ahmed K Toma
BACKGROUND: Idiopathic normal pressure hydrocephalus (INPH) has no reliable biomarker to assist in the selection of patients who could benefit from ventriculo-peritoneal (VP) shunt insertion. The neurodegenerative markers T-tau and Aβ1-42 have been found to successfully differentiate between Alzheimer's disease (AD) and INPH and therefore are candidate biomarkers for prognosis and shunt response in INPH. The aim of this study was to test the predictive value of cerebrospinal fluid (CSF) T-tau and Aβ1-42 for shunt responsiveness...
September 9, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28887286/why-does-the-health-related-quality-of-life-in-idiopathic-normal-pressure-hydrocephalus-fail-to-improve-despite-the-favorable-clinical-outcome
#6
Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville
OBJECTIVE: Occasionally a favorable clinical disease-specific outcome does not reflect into improved generic health-related quality of life (HRQoL) in patients with idiopathic normal pressure hydrocephalus (iNPH) one year after the installation of the cerebrospinal fluid (CSF) shunt. Our aim was to identify factors causing this discrepancy. METHODS: The one-year HRQoL outcome of 141 iNPH patients was evaluated using the generic 15D instrument, in which the minimum clinically important change/difference on the 0-1 scale has been estimated to be ± 0...
September 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28885121/epilepsy-headache-and-abdominal-pain-after-shunt-surgery-for-idiopathic-normal-pressure-hydrocephalus-the-inph-crash-study
#7
Jenny Larsson, Hanna Israelsson, Anders Eklund, Jan Malm
OBJECTIVE Adverse events related to shunt surgery are common and might have a negative effect on outcome in patients with idiopathic normal pressure hydrocephalus (INPH). The authors' objectives were to establish the frequencies of epilepsy, headache, and abdominal pain and determine their impact on patient quality of life (QOL), in long-term follow-up after shunt surgery for INPH. METHODS One hundred seventy-six shunt-treated patients with INPH (mean age 74 years) and 368 age- and sex-matched controls from the population were included...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28869371/quantitative-analysis-of-cerebrospinal-fluid-dynamics-at-phase-contrast-cine-mri-predictivity-of-neurosurgical-shunt-responsiveness-in-patients-with-idiopathic-normal-pressure-hydrocephalus
#8
Alessandro Stecco, Alessia Cassarà, Alberto Zuccalà, Mihaela B Anoaica, Egidio Genovese, Pier G Car, Gabriele P Panzarasa, Giuseppe Guzzardi, Alessandro Carriero
BACKGROUND: Aqueductal stroke volume (ACSV) measured by phase-contrast cine (PCC)-MRI has been proposed with controversy as a tool for the selection of patients with normal pressure hydrocephalus (NPH) as candidates for shunt-surgery. The aim of this study was to assess if PCC-MRI scan measurements of ACSV could select properly these patients. METHODS: We retrospectively reviewed charts and MRI of 38 shunted patients (72,16 ±6,16 years). ACSV measurements were performed 7-30 days before shunt and at the first and sixth months after surgery...
September 4, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28869176/-11-c-pib-retention-patterns-in-white-and-grey-cerebral-matter-in-idiopathic-normal-pressure-hydrocephalus-patients-a-visual-analysis
#9
J F Jiménez-Bonilla, R Quirce, M De Arcocha-Torres, I Martínez-Rodríguez, N Martínez-Amador, P Sánchez-Juan, A Pozueta, R Martín-Láez, I Banzo, E Rodríguez-Rodríguez
OBJECTIVE: Cortical cerebral amyloid disease, a hallmark of Alzheimer's disease, has also been observed in idiopathic normal pressure hydrocephalus (iNPH). The aim of this study was to compare the (11)C-PIB PET/CT retention pattern in iNPH patients and healthy subjects. MATERIAL AND METHODS: A comparison was made of the (11)C-PIB PET/CT retention pattern in 13 iNPH patients selected for surgical deviation, compared to a normal control population. Images were visually analyzed and scored for gray matter and white matter (WM) from 1 to 4 (slight to very high PIB retention)...
August 28, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28860216/arterial-spin-labeling-perfusion-mr-imaging-demonstrates-regional-cbf-decrease-in-idiopathic-normal-pressure-hydrocephalus
#10
J Virhammar, K Laurell, A Ahlgren, E-M Larsson
BACKGROUND AND PURPOSE: Regional cerebral blood flow has previously been studied in patients with idiopathic normal pressure hydrocephalus with imaging methods that require an intravenous contrast agent or expose the patient to ionizing radiation. The purpose of this study was to assess regional CBF in patients with idiopathic normal pressure hydrocephalus compared with healthy controls using the noninvasive quantitative arterial spin-labeling MR imaging technique. A secondary aim was to compare the correlation between symptom severity and CBF...
August 31, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28831624/vascular-parkinsonism-or-idiopathic-nph-new-insights-from-csf-pressure-analysis
#11
Claudia Giliberto, Giovanni Mostile, Salvatore Lo Fermo, Ester Reggio, Giorgia Sciacca, Alessandra Nicoletti, Mario Zappia
Differential diagnosis between vascular parkinsonism (VP) and idiopathic normal pressure hydrocephalus (iNPH) is particularly challenging due to similar clinical and neuroradiological features. The objective of this study is to differentiate VP with radiological evidence of ventricular enlargement (REVE) from iNPH on the basis of cerebrospinal fluid (CSF) hydrodynamics. CSF pressure components were investigated in patients with a clinical diagnosis of VP and REVE. Data of eight patients (seven men; age 76 ± 3...
August 22, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28828534/finger-tapping-and-verbal-fluency-post-tap-test-improvement-in-inph-its-value-in-differential-diagnosis-and-shunt-treatment-outcomes-prognosis
#12
Evangelia Liouta, Stylianos Gatzonis, Theodosis Kalamatianos, Aristotelis Kalyvas, Christos Koutsarnakis, Faidon Liakos, Christos Anagnostopoulos, Spyridon Komaitis, Dimitris Giakoumettis, George Stranjalis
BACKGROUND: Idiopathic normal pressure hydrocephalus (INPH) diagnosis is challenging as it can be mimicked by other neurological conditions, such as neurodegenerative dementia and motor syndromes. Additionally, outcomes after lumbar puncture (LP) tap test and shunt treatment may vary due to the lack of a common protocol in INPH assessment. The present study aimed to assess whether a post-LP test amelioration of frontal cognitive dysfunctions, characterizing this syndrome, can differentiate INPH from similar neurological conditions and whether this improvement can predict INPH post-shunt outcomes...
August 21, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28800199/intracranial-elastance-is-increased-in-idiopathic-intracranial-hypertension
#13
Jason T Chisholm, Padmaja Sudhakar, Abdulnasser N Alhajeri, Jonathan H Smith
BACKGROUND: To date, no pathophysiologic model has sufficiently accounted for all the findings encountered in patients with idiopathic intracranial hypertension (IIH). Intracranial elastance is an index of volume-buffering capacity known to play a role in certain disorders of CSF dynamics, which has not been previously investigated in relation to IIH patients. METHODS: Single-center retrospective cohort study from July 1, 2011 to July 1, 2016. We collected values for opening pressure (PO ), closing pressure (PC ), volume (V) of CSF removed, as well as demographic and clinical covariates...
August 11, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28756599/long-term-monitoring-of-intracranial-pressure-in-normal-pressure-hydrocephalus-and-other-csf-disorders
#14
EDITORIAL
Zofia Czosnyka, Marek Czosnyka
Long-term monitoring of intracranial pressure is a useful method in the diagnosis of complex hydrocephalus and CSF disorders. This editorial discusses various criteria for the interpretation of ICP monitoring in normal pressure hydrocephalus, idiopathic intracranial hypertension and in patients with implanted hydrocephalus shunts.
July 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28734501/-idiopathic-normal-pressure-hydrocephalus-high-incidence-in-people-over-80-years-of-age
#15
Josep Maria Aragonès, Jacint Altimiras, Francisco Alonso, Pere Roura, Sebastián Alfonso, Lorena Bajo
INTRODUCTION: Idiopathic normal pressure hydrocephalus is usually observed in adults over 60 years of age. The highest incidence of cases is between 70 and 80 years-old, and it could be under-diagnosed in over 80 year-olds. OBJECTIVE: A description is presented on the overall incidence and age group incidence, the delay in the diagnosis, and main outcomes. PATIENTS AND METHODS: A descriptive study was performed on patients with idiopathic normal pressure hydrocephalus, in the population of Osona County during the years 2010-2015...
July 19, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28716246/cognitive-impairment-predicts-worse-short-term-response-to-spinal-tap-test-in-normal-pressure-hydrocephalus
#16
Thomas Wolfsegger, Raffi Topakian
INTRODUCTION: In patients with idiopathic normal pressure hydrocephalus (iNPH), the spinal tap test (STT) is commonly used to predict ventriculoperitoneal shunt responsiveness. Clinical improvement following STT usually is measured by testing gait function. In our study, we investigated the impact of cognitive impairment on gait improvement after STT. METHODS: 22 patients with the clinical and radiological diagnosis of iNPH underwent gait analyses (mobile measuring system Medilogic) before and 2-4h after STT in self-paced gait velocity over 7m...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714010/ptprq-as-a-potential-biomarker-for-idiopathic-normal-pressure-hydrocephalus
#17
Yuki Nagata, Masahiko Bundo, Saiko Sugiura, Masahiro Kamita, Masaya Ono, Kotaro Hattori, Sumiko Yoshida, Yu-Ichi Goto, Katsuya Urakami, Shumpei Niida
Idiopathic normal pressure hydrocephalus (iNPH) is caused by the accumulation of cerebrospinal fluid (CSF) and is characterized by gait disturbance, urinary incontinence, and dementia. iNPH dementia is treatable by shunt operation; however, since the cognitive symptoms of iNPH are often similar to those of other dementias, including Alzheimer's disease (AD), accurate diagnosis of iNPH is difficult. To overcome this problem, the identification of novel diagnostic markers to distinguish iNPH and AD is warranted...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28711405/a-unique-glycan-isoform-of-transferrin-in-cerebrospinal-fluid-a-potential-diagnostic-marker-for-neurological-diseases
#18
REVIEW
Kyoka Hoshi, Yuka Matsumoto, Hiromi Ito, Kiyoshi Saito, Takashi Honda, Yoshiki Yamaguchi, Yasuhiro Hashimoto
BACKGROUND: Cerebrospinal fluid (CSF) is sequestered from blood by the blood-brain barrier and directly communicates with brain parenchymal interstitial fluid, leading to contain specific biomarkers of neurological diseases. SCOPE OF REVIEW: CSF contains glycan isoforms of transferrin (Tf): one appears to be derived from the brain and the other from blood. MAJOR CONCLUSIONS: CSF contains two glycan-isoforms; brain-type Tf and serum-type Tf...
October 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28652949/cerebrospinal-fluid-total-tau-is-increased-in-normal-pressure-hydrocephalus-patients-who-undergo-successful-lumbar-drain-trials
#19
Geoffrey Baird, Thomas J Montine, Jason J Chang, Shu-Ching Hu, Anthony M Avellino
BACKGROUND: Idiopathic normal pressure hydrocephalus (INPH) is a neurologic disease that affects <1% of those aged >65 years, but is difficult to distinguish from other diseases that present in this age group, such as Alzheimer's disease. Large volume lumbar puncture and an external lumbar drain trial (ELD) are used to make a clinical diagnosis of INPH, but the accuracy of ELD is suspected. OBJECTIVE: To investigate proteomic cerebrospinal fluid (CSF) biomarker patterns in patients with INPH undergoing ELD to develop a quantitative diagnostic...
May 22, 2017: Curēus
https://www.readbyqxmd.com/read/28628634/protein-signature-in-cerebrospinal-fluid-and-serum-of-alzheimer-s-disease-patients-the-case-of-apolipoprotein-a-1-proteoforms
#20
Chiara Fania, Beatrice Arosio, Daniele Capitanio, Enrica Torretta, Cristina Gussago, Evelyn Ferri, Daniela Mari, Cecilia Gelfi
In the diagnosis of Alzheimer's disease (AD) total tau (T-tau), tau phosphorylated at threonine 181 (P-tau181), and the 42 amino acid isoform of alpha β-amyloid (Aβ) are well established surrogate CSF markers. However, there is a constant need for new diagnostic markers to identify the disease at a very early stage. The identification of new molecules for AD diagnosis and monitoring in CSF is hampered by several "confounding" factors including intra- and inter-individual, pre-analytical and analytical variabilities...
2017: PloS One
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