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Idiopathic normal pressure hydrocephalus

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https://www.readbyqxmd.com/read/29163345/fluid-distribution-pattern-in-adult-onset-congenital-idiopathic-and-secondary-normal-pressure-hydrocephalus-implications-for-clinical-care
#1
Shigeki Yamada, Masatsune Ishikawa, Kazuo Yamamoto
Objective: In spite of growing evidence of idiopathic normal-pressure hydrocephalus (NPH), a viewpoint about clinical care for idiopathic NPH is still controversial. A continuous divergence of viewpoints might be due to confusing classifications of idiopathic and adult-onset congenital NPH. To elucidate the classification of NPH, we propose that adult-onset congenital NPH should be explicitly distinguished from idiopathic and secondary NPH. Methods: On the basis of conventional CT scan or MRI, idiopathic NPH was defined as narrow sulci at the high convexity in concurrent with enlargement of the ventricles, basal cistern and Sylvian fissure, whereas adult-onset congenital NPH was defined as huge ventricles without high-convexity tightness...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29150794/shunt-surgery-in-idiopathic-normal-pressure-hydrocephalus-is-cost-effective-a-cost-utility-analysis
#2
Mats Tullberg, Josefine Persson, Jakob Petersen, Per Hellström, Carsten Wikkelsø, Åsa Lundgren-Nilsson
BACKGROUND: The objective was to evaluate the cost-effectiveness of shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: Health-related quality of life was evaluated before and 6 months after surgery using the EQ-5D-3 L (EuroQOL group five-dimensions health survey) in 30 patients (median age, 71 years; range, 65-89 years) diagnosed with iNPH. The costs associated with shunt surgery were assessed by a detailed survey with interviews and extraction of register data concerning the cost of hospital care, primary care, residential care, home-care service and informal care...
November 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29128930/prognostic-value-of-amyloid-pet-scan-in-normal-pressure-hydrocephalus
#3
Hyemin Jang, Seong Beom Park, Yeshin Kim, Ko Woon Kim, Jung Il Lee, Sung Tae Kim, Kyung Han Lee, Eun-Suk Kang, Yeong Sim Choe, Sang Won Seo, Hee Jin Kim, Yeo Jin Kim, Cindy W Yoon, Duk L Na
Amyloid positron emission tomography ([18F] florbetaben (FBB) PET) can be used to determine concomitant Alzheimer's disease (AD) in idiopathic normal pressure hydrocephalus (iNPH) patients. FBB PET scans and the tap test were performed in 31 patients with clinically suspected iNPH, and amyloid positive (iNPH/FBB+) and negative (iNPH/FBB-) groups were compared with respect to clinical characteristics. We evaluated prognostic value of FBB PET scans by analyzing the response to the tap test using a linear mixed model...
November 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29125088/cerebrospinal-fluid-biomarkers-as-predictors-of-shunt-response-in-idiopathic-normal-pressure-hydrocephalus-a-systematic-review
#4
Tyler Pfanner, Alexandre Henri-Bhargava, Stephanie Borchert
BACKGROUND: The widely accepted treatment for idiopathic normal-pressure hydrocephalus (iNPH) is a cerebrospinal fluid (CSF) diversion shunt procedure, to which approximately 80% of patients will respond. The purpose of this systematic review was to identify which CSF biomarkers have been investigated in predicting shunt responsiveness in iNPH patients, and to analyze the level of evidence for each. METHODS: To find all relevant articles, a comprehensive search of Medline, Embase, and PsycINFO was conducted...
November 10, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29114272/endoscopic-third-ventriculostomy-in-normal-pressure-hydrocephalus-and-symptomatic-long-standing-overt-ventriculomegaly
#5
Mustafa Balevi
Objectives: The aim of this study is to define the role and effectiveness for an endoscopic third ventriculostomy (ETV) in patients with seconder normal pressure hydrocephalus(SNPH), idiopathic normal pressure hydrocephalus (INPH) and symptomatic longstanding overt ventriculomegaly (SLOVA). Materials and Methods: 3 patients with SLOVA, 3 patients with INPH and 3 patients with SNPH underwent ETV were studied retrospectively. The patients had a follow-up of 1-6 years...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29109063/normal-pressure-hydrocephalus-shunt-patients-have-fewer-complications-than-other-shunt-patients
#6
Pascale Schenker, Lennart Stieglitz, Beate Sick, Martin N Stienen, Luca Regli, Johannes Sarnthein
BACKGROUND: Ventriculoperitoneal (VP) shunting is a well-established therapy for hydrocephalus. However, complications are frequent. The incidence of idiopathic normal pressure hydrocephalus (NPH) rises with the aging of the population. We evaluated the functional status of patients and the classification of complications associated with VP shunt procedures in our center. METHODS: We recorded all VP-shunt procedures in our prospective patient registry from January 2013 to December 2015...
November 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29103634/efficacy-of-endoscopic-third-ventriculostomy-in-old-aged-patients-with-normal-pressure-hydrocephalus
#7
Young Sill Kang, Eun-Kyung Park, Ju-Seong Kim, Dong-Seok Kim, Ulrich-Wilhelm Thomale, Kyu-Won Shim
Normal pressure hydrocephalus (NPH) is a chronic disorder caused by interrupted CSF absorption or flow. Generally, shunt placement is first option for NPH treatment. Due to complications of ventriculo-peritoneal (VP) shunt placement, endoscopic third ventriculostomy (ETV) can be considered as an alternative treatment option. Here we report the efficacy of ETV especially in old aged patients with normal pressure hydrocephalus. Total 21 old aged patients with communicating hydrocephalus with opening pressure, measured via lumbar puncture, less than 20cm H2O underwent ETV...
October 23, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29103031/transcranial-sonography-in%C3%A2-neurodegenerative-diseases-with-cognitive-decline
#8
Silvia Favaretto, Uwe Walter, Claudio Baracchini, Annachiara Cagnin
Transcranial sonography (TCS) of the brain parenchyma detects alterations in the substantia nigra (SN), raphe nuclei, and basal ganglia; this technique has been established as a tool for the early diagnosis of Parkinson's disease and differential diagnosis from atypical parkinsonian syndromes. Here, we aimed to review the main applications of TCS in neurodegenerative diseases presenting with dementia syndrome, focusing on Alzheimer's disease (AD), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration, idiopathic normal pressure hydrocephalus, and atypical and secondary parkinsonisms...
November 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29076787/subdural-hematomas-in-1846-patients-with-shunted-idiopathic-normal-pressure-hydrocephalus-treatment-and-long-term-survival
#9
Nina Sundström, Marcus Lagebrant, Anders Eklund, Lars-Owe D Koskinen, Jan Malm
OBJECTIVE Subdural hematoma (SDH) is the most common serious adverse event in patients with shunts. Adjustable shunts are used with increasing frequency and make it possible to noninvasively treat postoperative SDH. The objective of this study was to describe the prevalence and treatment preferences of SDHs, based on fixed or adjustable shunt valves, in a national cohort of patients with shunted idiopathic normal pressure hydrocephalus (iNPH), as well as to evaluate the effect of SDH and treatment on long-term survival...
October 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29055382/subdural-effusion-protects-the-aging-brain-from-harmful-ventriculomegaly
#10
Chun-Chih Liao, Furen Xiao
The human brain loses its volume and its function during aging. The solid part of the brain within the intracranial space, the brain parenchyma, decreases in volume with age; while the cerebrospinal fluid (CSF) volume increases. With progressive loss of brain parenchymal volume (BPV), CSF may shift from cerebral ventricles to the subdural space, forming subdural effusion (SDE), whose role in the brain aging process remains unclear. We hypothesize that damages associated with ventriculomegaly can be lessened after formation of SDE...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29047355/hyperdynamic-csf-motion-profiles-found-in-idiopathic-normal-pressure-hydrocephalus-and-alzheimer-s-disease-assessed-by-fluid-mechanics-derived-from-magnetic-resonance-images
#11
Ken Takizawa, Mitsunori Matsumae, Naokazu Hayashi, Akihiro Hirayama, Satoshi Yatsushiro, Kagayaki Kuroda
BACKGROUND: Magnetic resonance imaging (MRI) does not only ascertain morphological features, but also measures physiological properties such as fluid velocity or pressure gradient. The purpose of this study was to investigate cerebrospinal fluid (CSF) dynamics in patients with morphological abnormalities such as enlarged brain ventricles and subarachnoid spaces. We used a time-resolved three dimensional phase contrast (3D-PC) MRI technique to quantitatively evaluate CSF dynamics in the Sylvian aqueduct of healthy elderly individuals and patients with either idiopathic normal pressure hydrocephalus (iNPH) or Alzheimer's disease (AD) presenting with ventricular enlargement...
October 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29040647/brain-capillary-ultrastructure-in-idiopathic-normal-pressure-hydrocephalus-relationship-with-static-and-pulsatile-intracranial-pressure
#12
Vigdis Andersen Eidsvaag, Hans-Arne Hansson, Kjell Heuser, Erlend A Nagelhus, Per K Eide
Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease of unknown cause. We investigated the morphology of capillaries in frontal cortex biopsies from iNPH patients and related the observations to overnight intracranial pressure (ICP) scores. A biopsy (0.9×10 mm) was taken from where the ICP sensor subsequently was inserted. Brain capillaries were investigated by electron microscopy of biopsies from 27 iNPH patients and 10 reference subjects, i.e. patients (not healthy individuals) without cerebrospinal fluid circulation disturbances, in whom normal brain tissue was removed as part of necessary neurosurgical treatment...
December 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29023635/intermittent-gait-disturbance-in-idiopathic-normal-pressure-hydrocephalus
#13
Y Nikaido, Y Kajimoto, A Tucker, K Kuroda, H Ohno, T Akisue, R Saura, T Kuroiwa
OBJECTIVES: We identified intermittent gait disturbance (IGD) observed in the mild stage of idiopathic normal pressure hydrocephalus (iNPH). The first purpose of this study was to clarify the temporal gait profile of IGD during long-distance gait. The second purpose was to confirm the difference in treatment effect after cerebrospinal fluid (CSF) shunting in patients with and without IGD. MATERIALS AND METHODS: Fourteen consecutive iNPH patients with mild gait disturbance with a timed up-and-go (TUG) of <20 seconds were prospectively enrolled in the study...
October 11, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29022960/idiopathic-intracranial-hypertension-in-a-pubertal-paediatric-indian-patient
#14
Anand Aggarwal, Prempal Kaur, Kanika Chhabra, Karamjit Singh, Piyush Goyal
BACKGROUND: Idiopathic Intracranial Hypertension (IIH) is characterised by raised intracranial pressure (ICP) with normal cerebrospinal fluid (CSF) composition and absence of hydrocephalus or space occupying lesions. IIH is a rare disease in children. It can lead to visual impairment but prompt diagnosis and treatment in most of the cases will prevent potentially permanent visual loss. OBJECTIVE: To report a rare case of Idiopathic Intracranial Hypertension in a pubertal child, clinical features, and findings of Magnetic Resonance Imaging (MRI) and visual field of this case...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28987681/the-evans-index-revisited-new-cut-off-levels-for-use-in-radiological-assessment-of-ventricular-enlargement-in-the-elderly
#15
Maiken K Brix, Eric Westman, Andrew Simmons, Geir Andre Ringstad, Per Kristian Eide, Kari Wagner-Larsen, Christian M Page, Valeria Vitelli, Mona K Beyer
BACKGROUND AND PURPOSE: Assessment of ventricular enlargement is subjective and based on the radiologist's experience. Linear indices, such as the Evans Index (EI), have been proposed as markers of ventricular volume with an EI≥0.3 indicating pathologic ventricular enlargement in any subject. However, normal range for EI measured on magnetic resonance imaging (MRI) scans are lacking in healthy elderly according to age and sex. We propose new age and sex specific cut-off values for ventricular enlargement in the elderly population...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987185/cerebrospinal-fluid-circulation-and-hydrocephalus
#16
Ville Leinonen, Ritva Vanninen, Tuomas Rauramaa
Hydrocephalus (HC) is classically defined as dynamic imbalance between the production and absorption of cerebrospinal fluid (CSF) leading to enlarged ventricles. Potential causative factors include various brain disorders like tumors causing obstruction of CSF flow within the ventricular system or the subarachnoid space. Classification of HC is based on the site of CSF flow obstruction guiding optimal treatment, with endoscopic third ventriculostomy in intraventricular obstruction and CSF shunt in communicating HC...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28984604/alzheimer-s-disease-related-polymorphisms-in-shunt-responsive-idiopathic-normal-pressure-hydrocephalus
#17
Joel Huovinen, Seppo Helisalmi, Jussi Paananen, Tiina Laiterä, Maria Kojoukhova, Anna Sutela, Ritva Vanninen, Marjo Laitinen, Tuomas Rauramaa, Anne M Koivisto, Anne M Remes, Hilkka Soininen, Mitja Kurki, Annakaisa Haapasalo, Juha E Jääskeläinen, Mikko Hiltunen, Ville Leinonen
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a late onset, surgically treated progressive brain disease caused by impaired cerebrospinal fluid dynamics and subsequent ventriculomegaly. Comorbid Alzheimer's disease (AD) seems to be frequent in iNPH. OBJECTIVE: We aim to evaluate the role of AD-related polymorphisms in iNPH. METHODS: Overall 188 shunt-operated iNPH patients and 688 controls without diagnosed neurodegenerative disease were included into analysis...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28969373/glymphatic-mri-in-idiopathic-normal-pressure-hydrocephalus
#18
Geir Ringstad, Svein Are Sirirud Vatnehol, Per Kristian Eide
The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so far been limited to rodents. We aimed to image cerebrospinal fluid flow characteristics and glymphatic function in humans, and applied the methodology in a prospective study of 15 idiopathic normal pressure hydrocephalus patients (mean age 71...
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28940258/is-there-even-such-a-thing-as-idiopathic-normal-pressure-hydrocephalus
#19
Clifford B Saper
No abstract text is available yet for this article.
October 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28923529/can-mri-water-apparent-diffusion-coefficient-adc-value-discriminate-between-idiopathic-normal-pressure-hydrocephalus-alzheimer-s-disease-and-subcortical-vascular-dementia
#20
Adrien Goujon, Mehdi Mejdoubi, Yvonne Purcell, Rishika Banydeen, Sylvie Colombani, Alessandro Arrigo
Numerous similarities in MRI and clinical symptoms exist between Alzheimer's disease (AD), subcortical vascular dementia (sVD) and possible idiopathic normal pressure hydrocephalus (iHPN). The aim of this study is to explore mean apparent coefficient diffusion (ADC) difference between theses diseases in different periventricular and deep white matter areas, as compared to healthy controls. This retrospective study analyzed mean ADC values of 120 patients in normal appearing deep white matter and lenticular nuclei, frontal, caudate nuclei corpus and parietal periventricular and deep white matter areas INPH group showed significantly lower ADC than sVD group in frontal periventricular region (1567...
September 15, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
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