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Idiopathic normal pressure hydrocephalus

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https://www.readbyqxmd.com/read/28507532/spectral-domain-optical-coherence-tomography-as-a-new-diagnostic-marker-for-idiopathic-normal-pressure-hydrocephalus
#1
Joana M Afonso, Manuel Falcão, Frank Schlichtenbrede, Fernando Falcão-Reis, Sérgio Estrela Silva, Till M Schneider
PURPOSE: Characterized by a progressive onset of gait disturbances, dementia, and urinary incontinence, idiopathic normal pressure hydrocephalus (iNPH) is considered a rare, but under-diagnosed disease. Non-invasive diagnostic markers are still insufficient to enable the diagnosis of iNPH with certainty and yet early treatment with ventriculoperitoneal (VP) shunting can reverse symptoms and stop disease progression. Vascular circulation abnormalities in iNPH may be reflected by changes in subfoveal and peripapillary choroidal thickness (PPChT)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28502690/the-clinical-effect-of-postoperative-hyperbaric-oxygen-therapy-on-idiopathic-normal-pressure-hydrocephalus-a-retrospective-and-comparative-analysis-of-61-patients-with-ventriculoperitoneal-shunt
#2
Lin Yang, Xingdong Wang, Yuping Li, Lang Chen, Zhengcun Yan, Lei She, Jun Dong
PURPOSE: The aim of the study was to examine the clinical effect of postoperative hyperbaric oxygen (HBO) therapy on symptoms and signs in the ventriculoperitoneal (VP) shunt insertion treatment of idiopathic normal pressure hydrocephalus (iNPH). MATERIALS AND METHODS: We conducted a retrospective analysis of 61 patients treated at our institution for iNPH since 2007. Patients were stratified into 2 groups according to undergoing pure VP shunt with gravitational valves (Group 1) or combined with postoperative HBO therapy (Group 2)...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28489610/invasive-and-noninvasive-means-of-measuring-intracranial-pressure-a-review
#3
Xuan Zhang, Joshua Medow, Bermans Iskandar, Fa Wang, Mehdi Shokoueinejad, Joyce Koueik, John Webster
Measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Cerebrospinal fluid (CSF) is produced by the choroid plexus in the brain ventricles (a set of communicating chambers), after which it circulates through the different ventricles and exits into the subarachnoid space (SAS) around the brain, where it is reabsorbed into the venous system. If the fluid does not drain out of the brain or get reabsorbed, the ICP increases, which may lead to brain damage or death...
May 10, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28486988/cerebrospinal-fluid-a%C3%AE-42-t-tau-and-p-tau-levels-in-the-differential-diagnosis-of-idiopathic-normal-pressure-hydrocephalus-a-systematic-review-and-meta-analysis
#4
REVIEW
Zhongyun Chen, Chunyan Liu, Jie Zhang, Norman Relkin, Yan Xing, Yanfeng Li
OBJECTIVES: The purpose of this systematic review and meta-analysis was to evaluate the performance of cerebrospinal fluid (CSF) beta amyloid 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) as potential diagnostic biomarkers for idiopathic normal-pressure hydrocephalus (iNPH) and to assess their utility indistinguishing patients with iNPH from those with Alzheimer disease (AD) and healthy normal controls. METHODS: Studies were identified by searching PubMed, Embase, the Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang Chinese Periodical Database, VIP Chinese database, and Chinese Bio-medicine Database (CBM) before August 2016...
May 10, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28472801/frontal-assessment-battery-and-cerebrospinal-fluid-tap-test-in-idiopathic-normal-pressure-hydrocephalus
#5
Pan-Woo Ko, Ho-Won Lee, Kyunghun Kang
BACKGROUND AND PURPOSE: Our aim in this study was to assess whether the frontal assessment battery (FAB) could contribute to the differential diagnosis of cerebrospinal fluid tap test (CSFTT) responders and nonresponders with the hypothesis that CSFTT nonresponders had greater frontal lobe dysfunction. We also explored whether a relationship exists between FAB scores and gait disturbance in idiopathic normal-pressure hydrocephalus (INPH) patients. METHODS: INPH subjects were selected in a consecutive order from a prospectively enrolled INPH registry...
May 5, 2017: European Neurology
https://www.readbyqxmd.com/read/28460569/neurological-outcome-and-frequency-of-overdrainage-in-normal-pressure-hydrocephalus-directly-correlates-with-implanted-ventriculo-peritoneal-shunt-valve-type
#6
Yavor Bozhkov, Karl Roessler, Nirjhar Hore, Michael Buchfelder, Sebastian Brandner
BACKGROUND: The correlation between neurological outcome and frequency of overdrainage in the management of idiopathic normal pressure hydrocephalus (iNPH) using different ventriculoperitoneal shunt valve types is under investigation. Thus, we retrospectively compared one group of iNPH patients implanted with a programmable differential pressure valve (DPV) with another group treated by implantation of a DPV in combination with a flow-regulated anti-siphon device valve (ASD). METHODS: A retrospective evaluation of clinical outcome and frequency of overdrainage of 40 consecutive iNPH patients following surgical management between 08/2010 and 08/2014 was performed...
May 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28448824/a-new-quantitative-method-to-assess-disproportionately-enlarged-subarachnoid-space-desh-in-patients-with-possible-idiopathic-normal-pressure-hydrocephalus-the-silver-index
#7
Nicola Benedetto, Carlo Gambacciani, Filippo Aquila, Davide Tiziano Di Carlo, Riccardo Morganti, Paolo Perrini
OBJECTIVES: Preoperative diagnosis of idiopathic normal-pressure hydrocephalus (iNPH) remains challenging. Recently, the presence of disproportionally enlarged subarachnoid spaces and hydrocephalus (DESH) on diagnostic images has been linked to clinical improvement after ventriculoperitoneal (VP) shunt placement. In this study we describe a new quantitative method to assess DESH on CT scans and to evaluate its prognostic value. PATIENTS AND METHODS: A multiplanar reconstruction software was used to retrospectively evaluate prospectively collected radiological data (CT scans) of 26 controls and 29 consecutive patients that underwent VP shunt placement for possible iNPH...
April 19, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28421283/shunting-of-the-over-80s-in-normal-pressure-hydrocephalus
#8
Simon D Thompson, J D Shand Smith, A A Khan, A M V Luoma, A K Toma, L D Watkins
BACKGROUND: Idiopathic normal pressure hydrocephalus is predominantly a disease of the elderly. By its nature, many of those who present to clinic are in advanced old age with multiple comorbidities. Majority of patients treated are younger than 80 years old. We present the clinical outcomes and complication rates of patients over the age of 80 years at the time of operation, during the past 11 years at a single institution. METHODS: Retrospective analysis of clinical records of all patients over the age of 80 years, who presented to our institution between 2006 and 2016...
June 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28420385/frontotemporal-dementia-as-a-comorbidity-to-idiopathic-normal-pressure-hydrocephalus-inph-a-short-review-of-literature-and-an-unusual-case
#9
REVIEW
V E Korhonen, E Solje, N M Suhonen, T Rauramaa, R Vanninen, A M Remes, V Leinonen
Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can present with similar symptoms. These include decline in executive functions, psychomotor slowness, and behavioural and personality changes. Ventricular enlargement is a key radiological finding in iNPH that may also be present in bvFTD caused by the C9ORF72 expansion mutation. Due to this, bvFTD has been hypothesized as a potential comorbidity to iNPH but bvFTD patients have never been identified in studies focusing in clinical comorbidities with iNPH...
April 19, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28378775/evidence-of-an-application-of-a-variable-mems-capacitive-sensor-for-detecting-shunt-occlusions
#10
David J Apigo, Philip L Bartholomew, Thomas Russell, Alokik Kanwal, Reginald C Farrow, Gordon A Thomas
A sensor was tested subdural and in vitro, simulating a supine infant with a ventricular-peritoneal shunt and controlled occlusions. The variable MEMS capacitive device is able to detect and forecast blockages, similar to early detection procedures in cancer patients. For example, with gradual occlusion development over a year, the method forecasts a danger over one month ahead of blockage. The method also distinguishes between ventricular and peritoneal occlusions. Because the sensor provides quantitative data on the dynamics of the cerebrospinal fluid, it can help test new therapies and work toward understanding hydrocephalus as well as idiopathic normal pressure hydrocephalus...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28348958/diffusion-imaging-of-reversible-and-irreversible-microstructural-changes-within-the-corticospinal-tract-in-idiopathic-normal-pressure-hydrocephalus
#11
Kouhei Kamiya, Masaaki Hori, Ryusuke Irie, Masakazu Miyajima, Madoka Nakajima, Koji Kamagata, Kouhei Tsuruta, Asami Saito, Misaki Nakazawa, Yuichi Suzuki, Harushi Mori, Akira Kunimatsu, Hajime Arai, Shigeki Aoki, Osamu Abe
The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt surgery, but prediction of treatment outcome is not established. We investigated changes of the corticospinal tract (CST) in iNPH before and after shunt surgery by using diffusion microstructural imaging, which infers more specific tissue properties than conventional diffusion tensor imaging. Two biophysical models were used: neurite orientation dispersion and density imaging (NODDI) and white matter tract integrity (WMTI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28347957/ventriculoatrial-versus-ventriculoperitoneal-shunt-complications-in-idiopathic-normal-pressure-hydrocephalus
#12
Alice L Hung, Tito Vivas-Buitrago, Atif Adam, Jennifer Lu, Jamie Robison, Benjamin D Elder, C Rory Goodwin, Ignacio Jusué-Torres, Daniele Rigamonti
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a devastating condition that affects the elderly population. Although ventriculoatrial (VA) shunts can be used to manage iNPH, concerns for associated cardiopulmonary and renal complications have decreased their use. However, the rate of these complications is not well understood within this population of patients. PATIENTS AND METHODS: A retrospective review of the electronic medical records of patients diagnosed with iNPH by the senior author between 1993 and 2015 was performed...
March 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28339331/differential-diagnosis-of-a-patient-referred-to-physical-therapy-for-dizziness-a-case-report
#13
Zachary Rethorn, Susan J Barlow, Emily Gavlick
STUDY DESIGN: Case report. BACKGROUND: Dizziness is a common and debilitating condition across the lifespan. Patients with this complaint must be carefully examined to determine the cause of dizziness, rule out the presence of central nervous system dysfunction, and determine the appropriateness of physical therapy intervention. CASE DESCRIPTION: A 90-year-old male was referred to physical therapy six months after the onset of dizziness. A thorough history was taken and examination was performed...
March 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28293475/nationwide-hospital-based-survey-of-idiopathic-normal-pressure-hydrocephalus-in-japan-epidemiological-and-clinical-characteristics
#14
Nagato Kuriyama, Masakazu Miyajima, Madoka Nakajima, Michiko Kurosawa, Wakaba Fukushima, Yoshiyuki Watanabe, Etsuko Ozaki, Yoshio Hirota, Akiko Tamakoshi, Etsuro Mori, Takeo Kato, Takahiko Tokuda, Akinori Urae, Hajime Arai
OBJECTIVES: There have been no nationwide epidemiological studies of idiopathic normal pressure hydrocephalus (iNPH) in Japan. Therefore, a nationwide epidemiologic survey of iNPH was performed to determine the number of cases and clinical characteristics by sex and diagnostic level. METHODS: The first survey examined the numbers of cases that met the diagnostic criteria of iNPH and those who underwent shunt operations in 2012. The second survey gathered patients' details to clarify their clinical background characteristics...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28259041/trunk-sway-in-idiopathic-normal-pressure-hydrocephalus-quantitative-assessment-in-clinical-practice
#15
Tomas Bäcklund, Jennifer Frankel, Hanna Israelsson, Jan Malm, Nina Sundström
BACKGROUND: In diagnosis and treatment of patients with idiopathic normal pressure hydrocephalus (iNPH), there is need for clinically applicable, quantitative assessment of balance and gait. Using a body-worn gyroscopic system, the aim of this study was to assess postural stability of iNPH patients in standing, walking and during sensory deprivation before and after cerebrospinal fluid (CSF) drainage and surgery. A comparison was performed between healthy elderly (HE) and patients with various types of hydrocephalus (ventriculomegaly (VM))...
February 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28257339/symri-of-the-brain-rapid-quantification-of-relaxation-rates-and-proton-density-with-synthetic-mri-automatic-brain-segmentation-and-myelin-measurement
#16
Akifumi Hagiwara, Marcel Warntjes, Masaaki Hori, Christina Andica, Misaki Nakazawa, Kanako Kunishima Kumamaru, Osamu Abe, Shigeki Aoki
Conventional magnetic resonance images are usually evaluated using the image signal contrast between tissues and not based on their absolute signal intensities. Quantification of tissue parameters, such as relaxation rates and proton density, would provide an absolute scale; however, these methods have mainly been performed in a research setting. The development of rapid quantification, with scan times in the order of 6 minutes for full head coverage, has provided the prerequisites for clinical use. The aim of this review article was to introduce a specific quantification method and synthesis of contrast-weighted images based on the acquired absolute values, and to present automatic segmentation of brain tissues and measurement of myelin based on the quantitative values, along with application of these techniques to various brain diseases...
March 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28251346/cost-effectiveness-analysis-of-shunt-surgery-for-idiopathic-normal-pressure-hydrocephalus-based-on-the-sinphoni-and-sinphoni-2-trials
#17
Masahiro Kameda, Shigeki Yamada, Masamichi Atsuchi, Teruo Kimura, Hiroaki Kazui, Masakazu Miyajima, Etsuro Mori, Masatsune Ishikawa, Isao Date
BACKGROUND: We showed that ventriculoperitoneal (VP) shunt and lumboperitoneal (LP) shunt surgeries are beneficial for patients with idiopathic normal pressure hydrocephalus (iNPH) in the Study of Idiopathic Normal Pressure Hydrocephalus on Neurological Improvement (SINPHONI; a multicenter prospective cohort study) and in SINPHONI-2 (a multicenter randomized trial). Although therapeutic efficacy is important, cost-effectiveness analysis is equally valuable. METHODS: Using both a set of assumptions and using the data from SINPHONI and SINPHONI-2, we estimated the total cost of treatment for iNPH, which consists of medical expenses (e...
June 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28247411/reversed-aqueductal-cerebrospinal-fluid-net-flow-in-idiopathic-normal-pressure-hydrocephalus
#18
L K Yin, J J Zheng, L Zhao, X Z Hao, X X Zhang, J Q Tian, K Zheng, Y M Yang
OBJECTIVES: The changes of CSF flow dynamics in idiopathic normal pressure hydrocephalus (iNPH) are not fully elucidated. Most previous studies took the whole cardiac cycle as a unit. In this work, it is divided into systole and diastole phase and compared between iNPH patients and normal elderly and paid special attention to the change of netflow direction. MATERIALS AND METHODS: Twenty iNPH patients according to international guideline and twenty healthy volunteers were included in this study and examined by MRI...
March 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28238737/mortality-and-risk-of-dementia-in-normal-pressure-hydrocephalus-a%C3%A2-population-study
#19
Daniel Jaraj, Carsten Wikkelsø, Katrin Rabiei, Thomas Marlow, Christer Jensen, Svante Östling, Ingmar Skoog
INTRODUCTION: We examined mortality, dementia, and progression of hydrocephalic symptoms among untreated individuals with idiopathic normal-pressure hydrocephalus (iNPH) in a population-based sample. METHODS: A total of 1235 persons were examined between 1986 and 2012. Shunted individuals were excluded. We examined 53 persons with hydrocephalic ventricular enlargement (probable iNPH: n = 24, asymptomatic or possible iNPH: n = 29). Comparisons were made with individuals without hydrocephalic ventricular enlargement...
February 24, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28185313/improvement-in-lower-urinary-tract-symptoms-across-multiple-domains-following-ventriculoperitoneal-shunting-for-idiopathic-normal-pressure-hydrocephalus
#20
Sarah C Krzastek, Samuel P Robinson, Harold F Young, Adam P Klausner
AIMS: The purpose of this study was to evaluate the change in lower urinary tract symptoms following ventriculoperitoneal shunting in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: Lower urinary tract symptoms in patients with new-onset iNPH were prospectively evaluated using validated questionnaires from the International Consultation on Incontinence to assess overactive bladder (ICIq-OAB), incontinence (ICIq-UI), and quality of life (ICIq-LUTqol), as well as the American Urological Association Symptom Score bother scale, prior to and following ventriculoperitoneal shunting for iNPH...
February 10, 2017: Neurourology and Urodynamics
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