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JOURNAL ARTICLE
Julia C Kontak, Hilary A T Caldwell, Rena Kulzycki, Camille L Hancock Friesen, Sara F L Kirk
Youth Participatory Action Research (YPAR) is an approach to research that engages youth across the research process. The peer researcher method is a technique used in YPAR where youth are trained in research and ethics to interview their peers. The purpose of this study was to: (i) describe the process of engaging youth as peer researchers in a Health Promoting Schools (HPS) and student engagement project and (ii) understand the peer researchers' perspectives of their experience throughout the project. Youth from across Nova Scotia, Canada in grades 7-10 (ages 12-16) were recruited as peer researchers in the Summer, 2022...
December 1, 2023: Health Promotion International
#22
JOURNAL ARTICLE
Evan L Barrios, Monty B Mazer, Patrick W McGonagill, Christian B Bergmann, Michael D Goodman, Robert W Gould, Mahil Rao, Valerie E Polcz, Ruth Davis, Drew Del Toro, Marvin Dirain, Alexandra Dram, Lucas Hale, Mohammad Heidarian, Caleb Y Kim, Tamara A Kucaba, Jennifer P Lanz, Ashley McCray, Alexandra Meszaros, Sydney M Miles, Candace Nelson, Ivanna Rocha, Elvia E Silva, Ricardo Ungaro, Andrew Walton, Julie Xu, Leilani Zeumer-Spataro, Anne M Drewry, Muxuan Liang, Letita E Bible, Tyler J Loftus, Isaiah R Turnbull, Philip A Efron, Kenneth E Remy, Scott C Brakenridge, Vladimir P Badovinac, Thomas S Griffith, Lyle L Moldawer, Richard S Hotchkiss, Charles C Caldwell
BACKGROUND: Sepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical outcomes and immunological endotyping of septic patients has generally relied on using blood protein or mRNA biomarkers, or static cell phenotyping. Here, we sought to determine whether functional immune responsiveness would yield improved precision. METHODS: An ex vivo whole blood enzyme-linked immunosorbent (ELISpot) assay for cellular production of interferon-γ (IFN-γ) was evaluated in 107 septic and 68 non-septic patients from five academic health centers using blood samples collected on days 1, 4 and 7 following ICU admission...
December 15, 2023: JCI Insight
#23
JOURNAL ARTICLE
Caitlyn J Bartsch, Jessica T Jacobs, Nooshin Mojahed, Elana Qasem, Molly Smith, Oliver Caldwell, Sophia Aaflaq, Jacob C Nordman
Traumatic stress has been shown to contribute to persistent behavioral changes, yet the underlying neural pathways are not fully explored. Structural plasticity, a form of long-lasting neural adaptability, offers a plausible mechanism. To scrutinize this, we used the mGRASP imaging technique to visualize synaptic modifications in a pathway formed between neurons of the posterior ventral segment of the medial amygdala and ventrolateral segment of the ventromedial hypothalamus (MeApv-VmHvl), areas we previously showed to be involved in stress-induced excessive aggression...
2023: Frontiers in Molecular Neuroscience
#24
JOURNAL ARTICLE
Donald R Caldwell, Katherine M Townsend, Bethany Kolbaba-Kartchner, Tanya Hadjian, Joseph Ivanic, Anna C Love, Beatrice Malvar, Jeremy Mills, Jennifer A Prescher, Martin J Schnermann
Bioluminescence imaging enables the sensitive tracking of cell populations and the visualization of biological processes in living systems. Bioluminescent luciferase/luciferin pairs with far-red and near-infrared emission benefit from the reduced competitive absorption by blood and tissue while also facilitating multiplexing strategies. Luciferins with extended π-systems, such as AkaLumine and recently reported CouLuc-1 and -3, can be used for bioluminescence imaging in this long wavelength regime. Existing synthetic routes to AkaLumine and similar π-extended compounds require a multistep sequence to install the thiazoline heterocycle...
December 14, 2023: Journal of Organic Chemistry
#25
REVIEW
Tim J Patterson, Adam Kedzierski, David McKinney, Jonathan Ritson, Chris McLean, Weidong Gu, Marcus Colyer, Scott F McClellan, Sarah C Miller, Grant A Justin, Annette K Hoskin, Kara Cavuoto, James Leong, Andrés Rousselot Ascarza, Fasika A Woreta, Kyle E Miller, Matthew C Caldwell, William G Gensheimer, Tom Williamson, Felipe Dhawahir-Scala, Peter Shah, Andrew Coombes, Gangadhara Sundar, Robert A Mazzoli, Malcolm Woodcock, Stephanie L Watson, Ferenc Kuhn, Sophia Halliday, Renata S M Gomes, Rupesh Agrawal, Richard J Blanch
TOPIC: Sympathetic ophthalmia (SO) is a sight threatening granulomatous panuveitis caused by a sensitizing event. The use of primary enucleation or primary evisceration, versus primary repair, as a risk management strategy following OGI remains controversial. CLINICAL RELEVANCE: This systematic review was conducted to report the incidence of SO after primary repair compared to after primary enucleation or primary evisceration. This enabled the reporting of an estimated number needed to treat (NNT)...
December 10, 2023: Ophthalmology
#26
JOURNAL ARTICLE
Elliott K Main, Matt Fuller, Vesela P Kovacheva, Rania Elkhateb, Kristen Azar, Morgan Caldwell, Vanna Chiem, Mindy Foster, Ronald Gibbs, Brenna L Hughes, Rebecca Johnson, Nobin Kottukapally, Magdalena Sanz Cortes, Melissa G Rosenstein, Laurence E Shields, Sylvia Sudat, Caitlin D Sutton, Paloma Toledo, Austin Traylor, Kurt Wharton, Melissa E Bauer
OBJECTIVE: To evaluate the screening performance characteristics of existing tools for the diagnosis of sepsis during delivery admissions. METHODS: This was a case-control study using electronic health record data, including vital signs and laboratory results, for all delivery admissions of patients with sepsis from 59 nationally distributed hospitals. Patients with sepsis were matched by gestational age at delivery in a 1:4 ratio with patients without sepsis to create a comparison group...
December 12, 2023: Obstetrics and Gynecology
#27
JOURNAL ARTICLE
Melissa E Bauer, Matt Fuller, Vesela Kovacheva, Rania Elkhateb, Kristen Azar, Morgan Caldwell, Vanna Chiem, Mindy Foster, Ronald Gibbs, Brenna L Hughes, Rebecca Johnson, Nobin Kottukapally, Melissa G Rosenstein, Magdalena Sanz Cortes, Laurence E Shields, Sylvia Sudat, Caitlin D Sutton, Paloma Toledo, Austin Traylor, Kurt Wharton, Elliott Main
OBJECTIVE: To evaluate the performance characteristics of existing screening tools for the prediction of sepsis during antepartum and postpartum readmissions. METHODS: This was a case-control study using electronic health record data obtained between 2016 and 2021 from 67 hospitals for antepartum sepsis admissions and 71 hospitals for postpartum readmissions up to 42 days. Patients in the sepsis case group were matched in a 1:4 ratio to a comparison cohort of patients without sepsis admitted antepartum or postpartum...
December 12, 2023: Obstetrics and Gynecology
#28
JOURNAL ARTICLE
Denise L Caldwell, Camila Da Silva, Austin McCoy, Harryson Avila, John C Bonkowski, Martin I Chilvers, Matthew Helm, Darcy E P Telenko, Anjali S Iyer-Pascuzzi
Tar spot, a disease caused by the ascomycete fungal pathogen Phyllachora maydis , is considered one of the most significant yield-limiting diseases of maize ( Zea mays L.) within the United States. P. maydis may also be found in association with other fungi, forming a disease complex which is thought to result in the characteristic fish eye lesions. Understanding how P. maydis colonizes maize leaf cells is essential for developing effective disease control strategies. Here, we used histological approaches to elucidate how P...
December 11, 2023: Phytopathology
#29
RANDOMIZED CONTROLLED TRIAL
Harris R Lieberman, John A Caldwell, Oshin Vartanian, Owen T Carmichael, J Philip Karl, Claire E Berryman, Kishore M Gadde, Philip J Niro, Melissa N Harris, Jennifer C Rood, Stefan M Pasiakos
RATIONALE: Behavioral effects of testosterone depend on dose, acute versus sustained formulation, duration of administration, personality, genetics, and endogenous levels of testosterone. There are also considerable differences between effects of endogenous and exogenous testosterone. OBJECTIVES: This study was the secondary behavioral arm of a registered clinical trial designed to determine if testosterone protects against loss of lean body mass and lower-body muscle function induced by a severe energy deficit typical of sustained military operations...
March 2024: Psychopharmacology
#30
Shunsuke Kimura, Petri Polonen, Lindsey Montefiori, Chun Shik Park, Ilaria Iacobucci, Allen Ej Yeoh, Andishe Attarbaschi, Andrew S Moore, Anthony Brown, Atsushi Manabe, Barbara Buldini, Burgess B Freeman, Chelsey Chen, Cheng Cheng, Chiew Kean Hui, Chi-Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, David T Teachey, Elena Varotto, Elisabeth M Paietta, Elizabeth D Arnold, Franco Locatelli, Gabriele Escherich, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A de Groot-Kruseman, Jacob M Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P P Meijerink, Jun J Yang, Junko Takita, Katarzyna Pawinska-Wasikowska, Kathryn G Roberts, Katie Han, Kenneth J Caldwell, Kjeld Schmiegelow, Kristine R Crews, Mariko Eguchi, Martin Schrappe, Martin Zimmerman, Masatoshi Takagi, Mellissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Mollie S Prater, Motohiro Kato, Noemi Reyes, Orietta Spinelli, Paul Thomas, Pauline Mazilier, Qingsong Gao, Riccardo Masetti, Rishi S Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Sharnise Mitchell, Shondra M Pruett-Miller, Shuhong Shen, Sima Jeha, Stefan Köhrer, Steven M Kornblau, Szymon Skoczeń, Takako Miyamura, Tiffaney L Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Yen-Chun Liu, Yunchao Chang, Zhaohui Gu, Zhongshan Cheng, Zhou Yinmei, Hiroto Inaba, Charles G Mullighan
PURPOSE: Gamma delta T-cell receptor-positive acute lymphoblastic leukemia (γδ T-ALL) is a high-risk but poorly characterized disease. METHODS: We studied clinical features of 200 pediatric γδ T-ALL, and compared the prognosis of 93 cases to 1,067 protocol-matched non-γδ T-ALL. Genomic features were defined by transcriptome and genome sequencing. Experimental modeling was used to examine the mechanistic impacts of genomic alterations...
November 8, 2023: medRxiv
#31
JOURNAL ARTICLE
Yuan Hou, Jessica Z K Caldwell, Justin D Lathia, James B Leverenz, Andrew A Pieper, Jeffrey Cummings, Feixiong Cheng
INTRODUCTION: The molecular mechanisms that contribute to sex differences, in particular female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and pathology, are incompletely understood. METHODS: To address this problem, we investigated cellular metabolism and immune responses ("immunometabolism endophenotype") across AD individuals as a function of sex with diverse clinical diagnosis of cognitive status at death (cogdx), Braak staging, and Consortium to Establish a Registry for AD (CERAD) scores using human cortex metabolomics and transcriptomics data from the Religious Orders Study / Memory and Aging Project (ROSMAP) cohort...
November 20, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#32
JOURNAL ARTICLE
Justin A DeBlauw, Anna I Churchill, Brigitte C Yunda, Christopher J Kotarsky, Abigail Caldwell, Stephen J Ives
Overweight and obesity (Ow/Ob) is a risk factor for cardiometabolic disease. Caloric restriction (CR) have been investigated but little is known about the acute effects of CR and often such diets are not standardized. Thus, we aimed to assess the impact of a new standardized 3-day CR diet (590 kcal/d intake) on cardiometabolic health in weight-stable Ow/Ob individuals. In a single-arm design, 15 Ow/Ob men and women were assessed pre-post a 3-day standardized CR diet; specifically, body weight/composition (%body fat, visceral fat score (Vfs), blood pressure (BP), and vascular stiffness (VS), resting energy expenditure (REE), substrate utilization (respiratory quotient, RQ), and blood glucose/lipid profile)...
November 2023: Physiological Reports
#33
JOURNAL ARTICLE
Mason T MacDonald, Rajasekaran R Lada, Gaye E MacDonald, Claude D Caldwell, Chibuike C Udenigwe
Needle abscission in balsam fir has been linked to both cold acclimation and changes in lipid composition. The overall objective of this research is to uncover lipid changes in balsam fir during cold acclimation and link those changes with postharvest abscission. Branches were collected monthly from September to December and were assessed for cold tolerance via membrane leakage and chlorophyll fluorescence changes at -5, -15, -25, -35, and -45 °C. Lipids were extracted and analyzed using mass spectrometry while postharvest needle abscission was determined gravimetrically...
October 28, 2023: International Journal of Molecular Sciences
#34
JOURNAL ARTICLE
Simon R Green, Caroline Wilson, Thomas C Eadsforth, Avinash S Punekar, Fabio K Tamaki, Gavin Wood, Nicola Caldwell, Barbara Forte, Neil R Norcross, Michael Kiczun, John M Post, Eva Maria Lopez-Román, Curtis A Engelhart, Iva Lukac, Fabio Zuccotto, Ola Epemolu, Helena I M Boshoff, Dirk Schnappinger, Chris Walpole, Ian H Gilbert, Kevin D Read, Paul G Wyatt, Beatriz Baragaña
There is an urgent need for new tuberculosis (TB) treatments, with novel modes of action, to reduce the incidence/mortality of TB and to combat resistance to current treatments. Through both chemical and genetic methodologies, polyketide synthase 13 (Pks13) has been validated as essential for mycobacterial survival and as an attractive target for Mycobacterium tuberculosis growth inhibitors. A benzofuran series of inhibitors that targeted the Pks13 thioesterase domain, failed to progress to preclinical development due to concerns over cardiotoxicity...
November 10, 2023: Journal of Medicinal Chemistry
#35
JOURNAL ARTICLE
Alexandra K Brooke, Daniel P Murrow, Kaejaren C N Caldwell, Colby E Witt, Ashley E Ross
The communication between the nervous and immune systems plays a crucial role in regulating immune cell function and inflammatory responses. Sympathetic neurons, which innervate the spleen, have been implicated in modulating immune cell activity. The neurotransmitter norepinephrine (NE), released by sympathetic neurons, influences immune cell responses by binding to adrenergic receptors on their surface. The alpha-2 adrenergic receptor (α2AR), expressed predominantly on sympathetic neurons, has received attention due to its autoreceptor function and ability to modulate NE release...
November 9, 2023: Cellular and Molecular Life Sciences: CMLS
#36
JOURNAL ARTICLE
Michael W Simon, Regine Bataille, Nicole S Caldwell, Bradford D Gessner, Luis Jodar, Erik Lamberth, Yahong Peng, Daniel A Scott, Lanyu Lei, Peter C Giardina, William C Gruber, Kathrin U Jansen, Allison Thompson, Wendy Watson
Use of pneumococcal conjugate vaccines (PCVs) has led to substantial reductions in the global burden of pediatric pneumococcal disease. Expansion of serotype coverage has been achieved by increasing PCV valency, but this may carry the potential risk of antibody interference. A complementary 7-valent PCV (cPCV7) including polysaccharide conjugates from 7 non-13-valent (PCV13) serotypes was developed to potentially complement PCV13-mediated protection and expand serotype coverage. This study evaluated cPCV7 and PCV13 coadministered in separate limbs or separated in time in infants...
August 2023: Human Vaccines & Immunotherapeutics
#37
REVIEW
Daniela Schiller, Alessandra N C Yu, Nelly Alia-Klein, Susanne Becker, Howard C Cromwell, Florin Dolcos, Paul J Eslinger, Paul Frewen, Andrew H Kemp, Edward F Pace-Schott, Jacob Raber, Rebecca L Silton, Elka Stefanova, Justin H G Williams, Nobuhito Abe, Moji Aghajani, Franziska Albrecht, Rebecca Alexander, Silke Anders, Oriana R Aragón, Juan A Arias, Shahar Arzy, Tatjana Aue, Sandra Baez, Michela Balconi, Tommaso Ballarini, Scott Bannister, Marlissa C Banta, Karen Caplovitz Barrett, Catherine Belzung, Moustafa Bensafi, Linda Booij, Jamila Bookwala, Julie Boulanger-Bertolus, Sydney Weber Boutros, Anne-Kathrin Bräscher, Antonio Bruno, Geraldo Busatto, Lauren M Bylsma, Catherine Caldwell-Harris, Raymond C K Chan, Nicolas Cherbuin, Julian Chiarella, Pietro Cipresso, Hugo Critchley, Denise E Croote, Heath A Demaree, Thomas F Denson, Brendan Depue, Birgit Derntl, Joanne M Dickson, Sanda Dolcos, Anat Drach-Zahavy, Olga Dubljević, Tuomas Eerola, Dan-Mikael Ellingsen, Beth Fairfield, Camille Ferdenzi, Bruce H Friedman, Cynthia H Y Fu, Justine M Gatt, Beatrice de Gelder, Guido H E Gendolla, Gadi Gilam, Hadass Goldblatt, Anne Elizabeth Kotynski Gooding, Olivia Gosseries, Alfons O Hamm, Jamie L Hanson, Talma Hendler, Cornelia Herbert, Stefan G Hofmann, Agustin Ibanez, Mateus Joffily, Tanja Jovanovic, Ian J Kahrilas, Maria Kangas, Yuta Katsumi, Elizabeth Kensinger, Lauren A J Kirby, Rebecca Koncz, Ernst H W Koster, Kasia Kozlowska, Sören Krach, Mariska E Kret, Martin Krippl, Kwabena Kusi-Mensah, Cecile D Ladouceur, Steven Laureys, Alistair Lawrence, Chiang-Shan R Li, Belinda J Liddell, Navdeep K Lidhar, Christopher A Lowry, Kelsey Magee, Marie-France Marin, Veronica Mariotti, Loren J Martin, Hilary A Marusak, Annalina V Mayer, Amanda R Merner, Jessica Minnier, Jorge Moll, Robert G Morrison, Matthew Moore, Anne-Marie Mouly, Sven C Mueller, Andreas Mühlberger, Nora A Murphy, Maria Rosaria Anna Muscatello, Erica D Musser, Tamara L Newton, Michael Noll-Hussong, Seth Davin Norrholm, Georg Northoff, Robin Nusslock, Hadas Okon-Singer, Thomas M Olino, Catherine Ortner, Mayowa Owolabi, Caterina Padulo, Romina Palermo, Rocco Palumbo, Sara Palumbo, Christos Papadelis, Alan J Pegna, Silvia Pellegrini, Kirsi Peltonen, Brenda W J H Penninx, Pietro Pietrini, Graziano Pinna, Rosario Pintos Lobo, Kelly L Polnaszek, Maryna Polyakova, Christine Rabinak, S Helene Richter, Thalia Richter, Giuseppe Riva, Amelia Rizzo, Jennifer L Robinson, Pedro Rosa, Perminder S Sachdev, Wataru Sato, Matthias L Schroeter, Susanne Schweizer, Youssef Shiban, Advaith Siddharthan, Ewa Siedlecka, Robert C Smith, Hermona Soreq, Derek P Spangler, Emily R Stern, Charis Styliadis, Gavin B Sullivan, James E Swain, Sébastien Urben, Jan Van den Stock, Michael A Vander Kooij, Mark van Overveld, Tamsyn E Van Rheenen, Michael B VanElzakker, Carlos Ventura-Bort, Edelyn Verona, Tyler Volk, Yi Wang, Leah T Weingast, Mathias Weymar, Claire Williams, Megan L Willis, Paula Yamashita, Roland Zahn, Barbra Zupan, Leroy Lowe
Over the last decades, theoretical perspectives in the interdisciplinary field of the affective sciences have proliferated rather than converged due to differing assumptions about what human affective phenomena are and how they work. These metaphysical and mechanistic assumptions, shaped by academic context and values, have dictated affective constructs and operationalizations. However, an assumption about the purpose of affective phenomena can guide us to a common set of metaphysical and mechanistic assumptions...
March 2024: Neuroscience and Biobehavioral Reviews
#38
JOURNAL ARTICLE
Phoebe Valdes, Kenneth W Henry, Michael Q Fitzgerald, Koushik Muralidharan, Andrew B Caldwell, Srinivasan Ramachandran, Lawrence S B Goldstein, William C Mobley, Douglas R Galasko, Shankar Subramaniam
Non-familial Alzheimer's disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer's disease (EOAD) and constitutes ~ 5-6% of all AD cases (Mendez et al. in Continuum 25:34-51, 2019). While EOAD exhibits the same clinicopathological changes such as amyloid plaques, neurofibrillary tangles (NFTs), brain atrophy, and cognitive decline (Sirkis et al. in Mol Psychiatry 27:2674-88, 2022; Caldwell et al. in Mol Brain 15:83, 2022) as observed in the more prevalent late-onset AD (LOAD), EOAD patients tend to have more severe cognitive deficits, including visuospatial, language, and executive dysfunction (Sirkis et al...
November 3, 2023: Molecular Brain
#39
JOURNAL ARTICLE
Ann E Caldwell, Daniel K Cummings, Paul L Hooper, Benjamin C Trumble, Michael Gurven, Jonathan Stieglitz, Helen E Davis, Hillard Kaplan
Over 80% of adolescents worldwide are insufficiently active, posing massive public health and economic challenges. Declining physical activity (PA) and sex differences in PA consistently accompany transitions from childhood to adulthood in post-industrialized populations and are attributed to psychosocial and environmental factors. An overarching evolutionary theoretical framework and data from pre-industrialized populations are lacking. This cross-sectional study tests hypotheses from life history theory, that adolescent PA is inversely related to age, but this association is mediated by Tanner stage, reflecting higher and sex-specific energetic demands for growth and reproductive maturation...
November 8, 2023: Proceedings. Biological Sciences
#40
Alena Khmelinskaia, Neville P Bethel, Farzad Fatehi, Aleksandar Antanasijevic, Andrew J Borst, Szu-Hsueh Lai, Jing Yang John Wang, Bhoomika Basu Mallik, Marcos C Miranda, Andrew M Watkins, Cassandra Ogohara, Shane Caldwell, Mengyu Wu, Albert J R Heck, David Veesler, Andrew B Ward, David Baker, Reidun Twarock, Neil P King
Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. For example, clathrin coats adopt a wide variety of architectures to adapt to vesicular cargos of various sizes. Although computational methods for designing novel self-assembling proteins have advanced substantially over the past decade, most existing methods focus on designing static structures with high accuracy. Here we characterize the structures of three distinct computationally designed protein assemblies that each form multiple unanticipated architectures, and identify flexibility in specific regions of the subunits of each assembly as the source of structural diversity...
October 19, 2023: bioRxiv
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