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C Caldwell

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https://www.readbyqxmd.com/read/29154591/the-impact-of-comorbid-diagnoses-on-the-course-of-posttraumatic-stress-disorder-symptoms-in-residents-of-battered-women-s-shelters
#1
Katherine M Fedele, Nicole L Johnson, Jennifer C Caldwell, Yuliya Shteynberg, Sarah E Sanders, Samantha C Holmes, Dawn M Johnson
OBJECTIVE: The current investigation sought to explore the impact of the comorbidities of substance use disorder (SUD), major depressive disorder (MDD), and borderline personality disorder (BPD) on the trajectory of intimate partner violence (IPV)-related posttraumatic stress disorder (PTSD) symptoms across a 6-month follow-up period in IPV survivors who seek shelter. Research has found significant comorbidity of SUD, MDD, and BPD with PTSD (see Green et al., 2006; Kessler, Sonnega, Bromet, Hughes, & Nelson, 1995; Pagura et al...
November 20, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29140832/platelet-function-changes-in-a-time-dependent-manner-following-traumatic-brain-injury-in-a-murine-model
#2
Grace E Martin, Brent Xia, Young Kim, Mark D Johnson, Rosalie Veile, Lou Ann Friend, Amy T Makley, Charles C Caldwell, Michael D Goodman
Traumatic brain injury (TBI) results in systemic changes in coagulation and inflammation that contribute to post-traumatic morbidity and mortality. The potential interaction of platelets and pro-inflammatory cytokines in the modulation of coagulation, microthrombosis, and venous thromboembolic events after moderate TBI (TBI) has not been determined. Using a murine model, we hypothesized 1) that the degree of platelet-induced coagulation varies depending on the platelet aggregation agonist 2) platelet-induced coagulation changes in a time-dependent manner following TBI, and 3) changes in platelet-induced coagulation are mirrored by changes in the levels of circulating pro-inflammatory cytokines...
November 14, 2017: Shock
https://www.readbyqxmd.com/read/29139142/safety-of-orally-administered-usp-compliant-levothyroxine-sodium-tablets-in-dogs
#3
J E Hare, C M K Morrow, J Caldwell, W E Lloyd
The safety of synthetic levothyroxine sodium tablets (Thyro-Tabs® Canine; LLOYD, Inc.) in dogs was evaluated in a randomized, sham-dose controlled, parallel-group study. Young, healthy, euthyroid Beagle dogs were randomized into four groups (four females and four males per group) and received single daily doses of 0×, 2× (0.044 mg/kg), 6× (0.132 mg/kg), or 10× (0.22 mg/kg) the labeled starting dose of 0.022 mg kg(-1)  day(-1) for 182 days. Every 2 weeks, physical examinations, electrocardiology examinations, and sample collections for thyroid panel, hematology, serum biochemistry, coagulation panel, and urinalysis were performed...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29130735/evaluation-of-the-pharmacodynamic-effects-of-the-potassium-binder-rdx7675-in-mice
#4
James P Davidson, Andrew J King, Padmapriya Kumaraswamy, Jeremy S Caldwell, Paul Korner, Robert C Blanks, Jeffrey W Jacobs
INTRODUCTION: Hyperkalemia is a common complication in patients with heart failure or chronic kidney disease, particularly those who are taking inhibitors of the renin-angiotensin-aldosterone system. RDX7675, the calcium salt of a reengineered polystyrene sulfonate-based resin, is a potassium binder that is being investigated as a novel treatment for hyperkalemia. This study evaluated the pharmacodynamic effects of RDX7675 in mice, compared to 2 current treatments, sodium polystyrene sulfonate (SPS) and patiromer...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29113534/the-relationship-between-neuropsychological-tests-of-visuospatial-function-and-lobar-cortical-thickness
#5
Davor N Zink, Justin B Miller, Jessica Z K Caldwell, Christopher Bird, Sarah J Banks
INTRODUCTION: Tests of visuospatial function are often administered in comprehensive neuropsychological evaluations. These tests are generally considered assays of parietal lobe function; however, the neural correlates of these tests, using modern imaging techniques, are not well understood. In the current study we investigated the relationship between three commonly used tests of visuospatial function and lobar cortical thickness in each hemisphere. METHOD: Data from 374 patients who underwent a neuropsychological evaluation and MRI scans in an outpatient dementia clinic were included in the analysis...
November 7, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29102666/a-90-day-subchronic-gavage-toxicity-study-in-fischer-344-rats-with-3-methylfuran
#6
S Gill, M Kavanagh, W Cherry, C Bourque, D Caldwell, G Wang, G Bondy
A 90-day gavage study was conducted with 0.0, 0.02, 0.075, 0.25, 1.0 and 4.0 mg/kg bw/day dose groups of 3-methylfuran to identify a no-observed adverse effect level for hepatotoxicity and to characterize non-neoplastic effects including changes in gross anatomy, histopathology, clinical biochemistry and hematology. There were significant changes in the serum clinical biochemistry markers related to liver injury where males were more affected than the females for most parameters analysed. The serum liver injury marker γ-glutamyltransferase, alanine and aspartate aminotransferases were significantly increased in males in the 4...
November 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29080792/impact-of-shear-rate-pattern-on-post-occlusive-near-infrared-spectroscopy-microvascular-reactivity
#7
M Ramos Gonzalez, J T Caldwell, P A Branch, G C Wardlow, C D Black, J Campbell, R D Larson, C J Ade
The primary aim of the present study was to determine the impact of acute changes in shear rate patterns, in particular retrograde shear rate, on microvascular function in 15 healthy, young men and women as determined via the post-occlusive near-infrared spectroscopy (NIRS) microvascular reactivity response. Microvascular reactivity, via NIRS-derived measurements of post-occlusion tissue saturation index (TSI%) and total microvascular hemoglobin+myoglobin concentration ([Hb]total), were assessed in each participant before and immediately after exposure to a 30min retrograde shear treatment...
October 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29078905/sphingosine-rescues-aged-mice-from-pulmonary-pseudomonas-infection
#8
Teresa C Rice, Amanda M Pugh, Aaron P Seitz, Erich Gulbins, Vanessa Nomellini, Charles C Caldwell
BACKGROUND: Bacterial lung infection is a leading cause of death for those 65 y or older, often requiring intensive care unit admission and mechanical ventilation, which consumes considerable health care resources. Although administration of antibiotics is the standard of care for bacterial pneumonia, its overuse has led to the emergence of multidrug resistant organisms. Therefore, alternative strategies to help minimize the effects of bacterial pneumonia in the elderly are necessary...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29078420/helicase-sprnting-through-the-nanopore
#9
Colleen C Caldwell, Maria Spies
No abstract text is available yet for this article.
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29074490/lung-disease-phenotypes-caused-by-over-expression-of-combinations-of-alpha-beta-and-gamma-subunits-of-the-epithelial-sodium-channel-in-mouse-airways
#10
Alessandra Livraghi-Butrico, Kristen J Wilkinson, Allison S Volmer, Rodney C Gilmore, Troy D Rogers, Ray A Caldwell, Kimberlie A Burns, Charles R Esther, Marcus A Mall, Richard C Boucher, Wanda K O'Neal, Barbara R Grubb
The epithelial Na+ channel (ENaC) regulates airway surface hydration. In mouse airways, ENaC is composed of three subunits, alpha (α), beta (β), and gamma (γ), which are differentially expressed (α > β > γ). Airway-targeted overexpression of the β subunit results in Na+ hyperabsorption causing airway surface dehydration, hyperconcentrated mucus with delayed clearance, lung inflammation, and perinatal mortality. Notably, mice overexpressing the α or γ subunit do not exhibit airway Na+ hyperabsorption nor lung pathology...
October 26, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29073160/a-novel-flnc-frameshift-and-an-obscn-variant-in-a-family-with-distal-muscular-dystrophy
#11
Daniela Rossi, Johanna Palmio, Anni Evilä, Lucia Galli, Virginia Barone, Tracy A Caldwell, Rachel A Policke, Esraa Aldkheil, Christopher E Berndsen, Nathan T Wright, Edoardo Malfatti, Guy Brochier, Enrico Pierantozzi, Albena Jordanova, Velina Guergueltcheva, Norma Beatriz Romero, Peter Hackman, Bruno Eymard, Bjarne Udd, Vincenzo Sorrentino
A novel FLNC c.5161delG (p.Gly1722ValfsTer61) mutation was identified in two members of a French family affected by distal myopathy and in one healthy relative. This FLNC c.5161delG mutation is one nucleotide away from a previously reported FLNC mutation (c.5160delC) that was identified in patients and in asymptomatic carriers of three Bulgarian families with distal muscular dystrophy, indicating a low penetrance of the FLNC frameshift mutations. Given these similarities, we believe that the two FLNC mutations alone can be causative of distal myopathy without full penetrance...
2017: PloS One
https://www.readbyqxmd.com/read/29069651/staphylococcus-aureus-%C3%AE-toxin-induces-inflammatory-cytokines-via-lysosomal-acid-sphingomyelinase-and-ceramides
#12
Jie Ma, Erich Gulbins, Michael J Edwards, Charles C Caldwell, Martin Fraunholz, Katrin Anne Becker
BACKGROUND/AIMS: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock syndrome. Toxins that are released from S. aureus mediate many of these effects. Here, we aimed to identify molecular mechanisms how α-toxin, a major S. aureus toxin, induces inflammation. METHODS: Macrophages were isolated from the bone marrow of wildtype and acid sphingomyelinase-deficient mice, stimulated with S...
October 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29051521/evaluating-feasibility-of-an-automated-3-dimensional-scanner-using-raman-spectroscopy-for-intraoperative-breast-margin-assessment
#13
G Thomas, T-Q Nguyen, I J Pence, B Caldwell, M E O'Connor, J Giltnane, M E Sanders, A Grau, I Meszoely, M Hooks, M C Kelley, A Mahadevan-Jansen
Breast conserving surgery is the preferred treatment for women diagnosed with early stage invasive breast cancer. To ensure successful breast conserving surgeries, efficient tumour margin resection is required for minimizing tumour recurrence. Currently surgeons rely on touch preparation cytology or frozen section analysis to assess tumour margin status intraoperatively. These techniques have suboptimal accuracy and are time-consuming. Tumour margin status is eventually confirmed using postoperative histopathology that takes several days...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040968/neutrophils-kill-reactive-oxygen-species-resistant-pseudomonas-aeruginosa-by-sphingosine
#14
Katrin Anne Becker, Xiang Li, Aaron Seitz, Joerg Steinmann, Anne Koch, Edward Schuchman, Markus Kamler, Michael J Edwards, Charles C Caldwell, Erich Gulbins
BACKGROUND/AIMS: Cystic fibrosis (CF) is dominated by chronic inflammation and infection of the lung resulting in lung destruction and early death of patients. The lungs of CF patients are characterized by a massive accumulation of neutrophils. It requires definition why these massive numbers of neutrophils fail to eliminate typical CF pathogens like Staphylococcus aureus and Pseudomonas aeruginosa (P. aeruginosa) in CF lungs. METHODS: We determined ceramide, sphingosine and reactive oxygen species (ROS) in neutrophils from wildtype and CF mice and determined the effect of sphingosine and ROS alone or in combination on killing of different P...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29033941/functional-analysis-of-phagocyte-activity-in-whole-blood-from-hiv-tuberculosis-infected-individuals-using-a-novel-flow-cytometry-based-assay
#15
Ankur Gupta-Wright, Dumizulu Tembo, Kondwani C Jambo, Elizabeth Chimbayo, Leonard Mvaya, Shannon Caldwell, David G Russell, Henry C Mwandumba
The accurate assessment of immune competence through ex vivo analysis is paramount to our understanding of those immune mechanisms that lead to protection or susceptibility against a broad range of human pathogens. We have developed a flow cytometry-based, whole blood phagocyte functional assay that utilizes the inflammatory inducer zymosan, coupled to OxyBURST-SE, a fluorescent reporter of phagosomal oxidase activity. The assay measures both phagocytic uptake and the superoxide burst in the phagocyte populations in whole blood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29030433/dysregulation-of-the-mitochondrial-unfolded-protein-response-induces-non-apoptotic-dopaminergic-neurodegeneration-in-c-elegans-models-of-parkinson-s-disease
#16
Bryan A Martinez, Daniel A Petersen, Anthony L Gaeta, Samuel P Stanley, Guy A Caldwell, Kim A Caldwell
Due to environmental insult or innate genetic deficiency, protein folding environments of the mitochondrial matrix are prone to dysregulation, prompting the activation of a specific organellar stress-response mechanism, the mitochondrial unfolded protein response (UPR(MT)). In Caenorhabditis elegans, mitochondrial damage leads to nuclear translocation of the ATFS-1 transcription factor to activate the UPR(MT) After short-term acute stress has been mitigated, the UPR(MT) is eventually suppressed to restore homeostasis to C...
November 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29029912/prevalence-of-pediatric-alopecia-areata-among-572-617-dermatology-patients
#17
Chauncey C Caldwell, Sami K Saikaly, Robert P Dellavalle, James A Solomon
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29022701/genetic-and-pharmacological-discovery-for-alzheimer-s-disease-using-caenorhabditis-elegans
#18
Edward F Griffin, Kim A Caldwell, Guy A Caldwell
The societal burden presented by Alzheimer's disease warrants both innovative and expedient means by which its underlying molecular causes can be both identified and mechanistically exploited to discern novel therapeutic targets and strategies. The conserved characteristics, defined neuroanatomy, and advanced technological application of Caenorhabditis elegans render this metazoan an unmatched tool for probing neurotoxic factors. In addition, its short lifespan and importance in the field of aging make it an ideal organism for modeling age-related neurodegenerative disease...
October 25, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29017900/neural-electrode-resilience-against-dielectric-damage-may-be-improved-by-use-of-highly-doped-silicon-as-a-conductive-material
#19
Ryan Caldwell, Rohit Sharma, Pavel Takmakov, Matthew G Street, Florian Solzbacher, Prashant Tathireddy, Loren Rieth
BACKGROUND: Dielectric damage occurring in vivo to neural electrodes, leading to conductive material exposure and impedance reduction over time, limits the functional lifetime and clinical viability of neuroprosthetics. We used silicon micromachined Utah Electrode Arrays (UEAs) with iridium oxide (IrOx) tip metallization and parylene C dielectric encapsulation to understand the factors affecting device resilience and drive improvements. NEW METHOD: In vitro impedance measurements and finite element analyses were conducted to evaluate how exposed surface area of silicon and IrOx affect UEA properties...
October 7, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28981384/the-effects-of-a-korean-ginseng-ginst15-on-hypo-pituitary-adrenal-and-oxidative-activity-induced-by-intense-work-stress
#20
Shawn D Flanagan, William H DuPont, Lydia K Caldwell, Vincent H Hardesty, Emily C Barnhart, Matthew K Beeler, Emily M Post, Jeff S Volek, William J Kraemer
The effect of GINST15, an enzyme fermented ginseng supplement, on hormonal and inflammatory responses to physical stress in humans is unknown. The purpose of this investigation was to examine the constitutive and stress-induced effects of GINST15 supplement on hypo-pituitary-adrenal (HPA) and antioxidant activity in addition to muscle damage. Ten women (age: 38.7 ± 7.8 years; height: 163.81 ± 4.4 cm; body mass 76.0 ± 11.6 kg) and nine men (age: 41.2. ± 9.7 years; height: 177.4 ± 5...
October 5, 2017: Journal of Medicinal Food
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