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C Caldwell

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https://www.readbyqxmd.com/read/28416166/two-year-outcomes-of-balloon-occluded-retrograde-transvenous-obliteration-of-gastric-varices-in-liver-transplant-recipients-a-multi-institutional-study
#1
W E Saad, J F B Chick, R N Srinivasa, N Saad, S Kim, A Fischman, G Frey, A Al-Osaimi, S Caldwell
PURPOSE: To assess the 2-year effectiveness and safety of balloon-occluded retrograde transvenous obliteration (BRTO) for gastric varices (GVs) in liver transplant recipients. MATERIALS AND METHODS: Eleven liver transplant recipients underwent consecutive BRTO for GVs at four institutions. Patients included eight (73%) men and three (27%) women with mean age of 56 years±12 (SD) (range: 26-67 years). Underlying cause of liver transplantation was hepatitis C virus (HCV)-related cirrhosis in five (45%), alcohol- and HCV-related cirrhosis in three (27%), primary biliary cirrhosis in two (18%), and alcoholic cirrhosis in one (9%)...
April 13, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28398660/gestational-and-lactational-exposure-to-an-environmentally-relevant-mixture-of-brominated-flame-retardants-effects-on-neurodevelopment-and-metabolism
#2
Emily W Y Tung, Alice Kawata, Marc Rigden, Wayne J Bowers, Don Caldwell, Alison C Holloway, Bernard Robaire, Barbara F Hales, Michael G Wade
BACKGROUND: Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopmental effects with studies of pure substances more likely to report effects than studies of technical products. In addition, the influence of early BFR exposures on later development of metabolic disease-like symptoms has not been investigated...
April 17, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28383200/disease-burden-research-match-registered-trials-in-child-health-from-low-and-middle-income-and-high-income-countries
#3
Pathma D Joseph, Patrina Hy Caldwell, Elizabeth H Barnes, Jonathan C Craig
AIM: The aim of this study was to determine whether there is a match between the health problems that children face and the clinical trials that are being conducted, especially in low- and middle-income countries (LMICs). METHODS: All trials on the World Health Organisation International Clinical Trials Registry Platform registered from 2005 to 2013 were reviewed. The disease-specific focus of registered trials for children was compared to the global burden of disease for 2011 using World Health Organisation disability-adjusted life-year data...
April 6, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28375015/pd-catalyzed-acyl-c-o-bond-activation-for-selective-ring-opening-of-%C3%AE-methylene-%C3%AE-lactones-with-amines
#4
Christian A Malapit, Donald R Caldwell, Nicole Sassu, Samuel Milbin, Amy R Howell
A Pd-catalyzed ring-opening of β-lactones with various types of amines (primary, secondary, and aryl) to provide β-hydroxy amides with excellent selectivity toward acyl C-O bond cleavage is reported. The utility of this protocol is demonstrated in an asymmetric kinetic resolution providing enantioenriched α-methylene-β-lactones.
April 4, 2017: Organic Letters
https://www.readbyqxmd.com/read/28351998/analysis-of-al2o3-parylene-c-bilayer-coatings-and-impact-of-microelectrode-topography-on-long-term-stability-of-implantable-neural-arrays
#5
Ryan Caldwell, Himadri Mandal, Rohit Sharma, Florian Solzbacher, Prashant Tathireddy, Loren Rieth
OBJECTIVE: Performance of many dielectric coatings for neural electrodes degrades over time, contributing to loss of neural signals and evoked percepts. Studies using planar test substrates have found that a novel bilayer coating of atomic-layer deposited (ALD) Al2O3 and parylene C is a promising candidate for neural electrode applications, exhibiting superior stability to parylene C alone. However, initial results from bilayer encapsulation testing on non-planar devices have been less positive...
March 29, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28343583/indirect-hand-and-forearm-vasomotion-regional-variations-in-cutaneous-thermosensitivity-during-normothermia-and-mild-hyperthermia
#6
Catriona A Burdon, Kyoko Tagami, Joonhee Park, Joanne N Caldwell, Nigel A S Taylor
In this experiment, hand and forearm vasomotor activity was investigated during localised, but stable heating and cooling of the face, hand and thigh, under open-loop (clamped) conditions. It was hypothesised that facial stimulation would provoke the most potent vascular changes. Nine individuals participated in two normothermic trials (mean body temperature clamp: 36.6°C; water-perfused suit and climate chamber) and two mildly hyperthermic trials (37.9°C). Localised heating (+5°C) and cooling (-5°C) stimuli were applied to equal surface areas of the face, hand and thigh (perfusion patches: 15min), while contralateral forearm or hand blood flows (venous-occlusion plethysmography) were measured (separate trials)...
April 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28341550/sphingosine-s-role-in-epithelial-host-defense-a-natural-antimicrobial-and-novel-therapeutic
#7
Grace E Martin, Ryan M Boudreau, Caroline Couch, Katrin Anne Becker, Michael J Edwards, Charles C Caldwell, Erich Gulbins, Aaron Seitz
Sphingosine is a natural sphingolipid found in membranes of all eukaryotic cells. In addition to its functions in cell signaling, sphingosine has broad-spectrum antimicrobial properties. Sphingosine's role as an antimicrobial is important in tissues such as the skin and respiratory epithelium. Reduction in the normal sphingosine level is associated with problems related to infection susceptibility. Exogenous sphingosine may, therefore, be an effective antimicrobial therapeutic. Inhaled nebulized sphingosine has been shown to be effective at both preventing and treating pneumonia in multiple mouse models...
March 21, 2017: Biochimie
https://www.readbyqxmd.com/read/28320971/neuroendocrine-androgen-action-is-a-key-extraovarian-mediator-in-the-development-of-polycystic-ovary-syndrome
#8
Aimee S L Caldwell, Melissa C Edwards, Reena Desai, Mark Jimenez, Robert B Gilchrist, David J Handelsman, Kirsty A Walters
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain unknown, mechanism-based treatments are not feasible and current management relies on treatment of symptoms. Hyperandrogenism is the most consistent PCOS characteristic; however, it is unclear whether androgen excess, which is treatable, is a cause or a consequence of PCOS. As androgens mediate their actions via the androgen receptor (AR), we combined a mouse model of dihydrotestosterone (DHT)-induced PCOS with global and cell-specific AR-resistant (ARKO) mice to investigate the locus of androgen actions that mediate the development of the PCOS phenotype...
April 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28318664/risk-assessment-of-patients-with-clinical-manifestations-of-cardiac-sarcoidosis-with-positron-emission-tomography-and-magnetic-resonance-imaging
#9
Paco E Bravo, Ganesh Raghu, David G Rosenthal, Shana Elman, Bradley J Petek, Laurie A Soine, Jeffrey H Maki, Kelley R Branch, Sofia C Masri, Kristen K Patton, James H Caldwell, Eric V Krieger
BACKGROUND: Prior studies have shown that late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) and fluorodeoxyglucose (FDG) positron emission tomography (PET) confer incremental risk assessment in patients with cardiac sarcoidosis (CS). However, the incremental prognostic value of the combined use of LGE and FDG compared to either test alone has not been investigated, and this is the aim of the present study. METHODS: Retrospective observational study of 56 symptomatic patients with high clinical suspicion for CS who underwent LGE-CMR and FDG-PET and were followed for the occurrence of death and/or malignant ventricular arrhythmias (VA)...
March 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28296622/a-cell-based-screening-approach-for-identifying-protein-degradation-regulators
#10
Scott Simanski, Marie E Maloof, Trey K Sato, Valerie Cavett, Jennifer Caldwell Busby, Nagi G Ayad
Cellular transitions are achieved by the concerted actions of regulated degradation pathways. In the case of the cell cycle, ubiquitin mediated degradation ensures unidirectional transition from one phase to another. For instance, turnover of the cell cycle regulator cyclin B1 occurs after metaphase to induce mitotic exit. To better understand pathways controlling cyclin B1 turnover, the N terminal domain of cyclin B1 was fused to luciferase to generate an N-cyclin B1-luciferase protein that can be used as a reporter for protein turnover...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28281135/resilience-resources-moderate-the-association-of-adverse-childhood-experiences-with-adulthood-inflammation
#11
Jean-Philippe Gouin, Warren Caldwell, Robbie Woods, William B Malarkey
BACKGROUND: Exposure to adverse childhood experiences (ACE) has been associated with elevated circulating inflammatory markers in adulthood. Despite the robust effect of ACE on later health outcomes, not all individuals exposed to ACE suffer from poor health. PURPOSE: The goal of this study was to evaluate whether current resilience resources may attenuate the impact of ACE on inflammatory markers among individuals with elevated C-reactive protein (CRP) levels. METHODS: Participants (N = 174) completed one-time self-report questionnaires assessing ACE exposure within the first 18 years of life and current resilience resources, and provided blood samples for interleukin-6 (IL-6) and CRP...
March 9, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28263851/the-effects-of-different-exercise-training-modalities-on-plasma-proenkephalin-peptide-f-in-women
#12
William H DuPont, William J Kraemer, Bradley C Nindl, Elaine C Lee, Maren S Fragala, Disa L Hatfield, Lydia K Caldwell, Emily M Post, Matthew K Beeler, Jeff S Volek, Carl M Maresh
Due to the important interactions of proenkephalin fragments (e.g., proenkephalin [107-140] Peptide F) to enhance activation of immune cells and potentially combat pain associated with exercise-induced muscle tissue damage, we examined the differential plasma responses of Peptide F to different exercise training programs. Participants were tested pre-training (T1), and after 8 weeks (T2) of training. Fifty-nine healthy women were matched and then randomly assigned to one of four groups: heavy resistance strength training (STR, n=18), high intensity endurance training (END, n=14), combined strength and endurance training (CMB, n=17), or control (CON, n=10)...
March 3, 2017: Peptides
https://www.readbyqxmd.com/read/28257408/implementing-a-multipartner-hpv-vaccination-assessment-and-feedback-intervention-in-an-integrated-health-system
#13
Holly C Groom, Stephanie A Irving, Jessica Caldwell, Rex Larsen, Sara Beaudrault, Lydia M Luther, Allison L Naleway
CONTEXT: Human papillomavirus (HPV) vaccine initiation rates are persistently lower than rates for other adolescent-recommended vaccines. Assessment and feedback interventions are a recommended strategy for improving vaccination rates. OBJECTIVE: To provide a guide for implementing a multipartner intervention to increase HPV vaccine initiation rates. SETTING: Nine primary care facilities within the Kaiser Permanente Northwest (KPNW) health care system...
March 1, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28242493/c-elegans-as-a-model-system-to-accelerate-discovery-for-parkinson-disease
#14
REVIEW
Bryan A Martinez, Kim A Caldwell, Guy A Caldwell
The nematode Caenorhabditis elegans possesses a wealth of opportunities to explore mechanisms which regulate metazoan complexity, basic cellular biology, and neuronal system attributes. Together, these provide a basis for tenable understanding of neurodegenerative disorders such as Parkinson disease (PD) through functional genomic analysis and pharmacological manipulation for the discovery of previously unknown genetic and environmental risk factors. The application of C. elegans has proven prescient in terms of the elucidation of functional effectors of cellular mechanisms underlying PD that translate to mammals...
February 24, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28230708/cell-derived-nanoparticles-are-endogenous-modulators-of-sepsis-with-therapeutic-potential
#15
Natalia Kunz, Brent T Xia, Kai-Uwe Kalies, Matthias Klinger, Timo Gemoll, Jens K Habermann, Brynne E Whitacre, Aaron P Seitz, Kathrin Kalies, Charles C Caldwell
Cell-derived nanoparticles (CDNPs) containing cytosolic proteins and RNAs/DNAs can be isolated from stressed eukaryotic cells. Previously, CDNPs isolated from cultured cells exerted immunomodulatory activities in different infections. Here, we sought to elucidate the role of CDNPs using a murine model of cecal ligation and puncture (CLP). We hypothesized that CDNPs influence the immune response at the site of infection, where severe cellular stress occurs. We observed early CDNP accumulation in the peritoneum after 4 h and continued CDNP presence 24 h after CLP...
February 22, 2017: Shock
https://www.readbyqxmd.com/read/28230331/the-development-and-assessment-of-the-worry-about-pain-questionnaire
#16
J C Lefebvre, M P Jensen, S J Waters, I R Molton, F J Keefe, D S Caldwell
BACKGROUND: Worry can be conceptualized as a cognitive-affective automatic process initiated in order to address uncertainty and potential personal inadequacies that could result in negative outcomes. The purpose of the current study was to develop a measure of pain-specific worry - the Worry About Pain Questionnaire (WAPQ). METHOD: In study 1, responses of 335 pain-free participants were used to complete an item analysis and exploratory factors analysis to develop and assess the internal structure of the WAPQ...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28225079/multiple-sodium-channel-isoforms-mediate-the-pathological-effects-of-pacific-ciguatoxin-1
#17
Marco C Inserra, Mathilde R Israel, Ashlee Caldwell, Joel Castro, Jennifer R Deuis, Andrea M Harrington, Angelo Keramidas, Sonia Garcia-Caraballo, Jessica Maddern, Andelain Erickson, Luke Grundy, Grigori Y Rychkov, Katharina Zimmermann, Richard J Lewis, Stuart M Brierley, Irina Vetter
Human intoxication with the seafood poison ciguatoxin, a dinoflagellate polyether that activates voltage-gated sodium channels (NaV), causes ciguatera, a disease characterised by gastrointestinal and neurological disturbances. We assessed the activity of the most potent congener, Pacific ciguatoxin-1 (P-CTX-1), on NaV1.1-1.9 using imaging and electrophysiological approaches. Although P-CTX-1 is essentially a non-selective NaV toxin and shifted the voltage-dependence of activation to more hyperpolarising potentials at all NaV subtypes, an increase in the inactivation time constant was observed only at NaV1...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224307/endocrinological-roles-for-testosterone-in-resistance-exercise-responses-and-adaptations
#18
David R Hooper, William J Kraemer, Brian C Focht, Jeff S Volek, William H DuPont, Lydia K Caldwell, Carl M Maresh
Chronic increases in testosterone levels can significantly increase hypertrophy and strength, as has been demonstrated by pharmacological intervention. However, decreases in basal testosterone levels can have the opposite result, as has been seen in hypogonadal populations. Because of these profound effects on hypertrophy and strength, testosterone has often been studied in conjunction with resistance exercise to examine whether the endocrine system plays a role in adaptations to the stimulus. Whereas some studies have demonstrated a chronic increase in basal testosterone, others have failed to find an adaptation to regular resistance exercise...
February 21, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28221065/the-american-psychological-association-task-force-assessment-of-violent-video-games-science-in-the-service-of-public-interest
#19
REVIEW
Sandra L Calvert, Mark Appelbaum, Kenneth A Dodge, Sandra Graham, Gordon C Nagayama Hall, Sherry Hamby, Lauren G Fasig-Caldwell, Martyna Citkowicz, Daniel P Galloway, Larry V Hedges
A task force of experts was convened by the American Psychological Association (APA) to update the knowledge and policy about the impact of violent video game use on potential adverse outcomes. This APA Task Force on Media Violence examined the existing literature, including the meta-analyses in the field, since the last APA report on media violence in 2005. Because the most recent meta-analyses were published in 2010 and reflected work through 2009, the task force conducted a search of the published studies from 2009-2013...
February 2017: American Psychologist
https://www.readbyqxmd.com/read/28209728/evaluation-of-cell-therapy-on-exercise-performance-and-limb-perfusion-in-peripheral-artery-disease-the-cctrn-pace-trial-patients-with-intermittent-claudication-injected-with-aldh-bright-cells
#20
Emerson C Perin, Michael P Murphy, Keith L March, Roberto Bolli, John Loughran, Phillip C Yang, Nicholas J Leeper, Ronald L Dalman, Jason Alexander, Timothy D Henry, Jay H Traverse, Carl J Pepine, R David Anderson, Scott Berceli, James T Willerson, Raja Muthupillai, Amir Gahremanpour, Ganesh Raveendran, Omaida Velasquez, Joshua M Hare, Ivonne Hernandez Schulman, Vijaykumar S Kasi, William R Hiatt, Bharath Ambale-Venkatesh, João A Lima, Doris A Taylor, Micheline Resende, Adrian P Gee, April G Durett, Jeanette Bloom, Sara Richman, Patricia G'Sell, Shari Williams, Fouzia Khan, Elsie Gyang Ross, Michelle R Santoso, JoAnne Goldman, Dana Leach, Eileen Handberg, Benjamin Cheong, Nichole Piece, Darcy DiFede, Barb Bruhn-Ding, Emily Caldwell, Judy Bettencourt, Dejian Lai, Linda Piller, Lara Simpson, Michelle Cohen, Shelly L Sayre, Rachel W Vojvodic, Lem Moyé, Ray F Ebert, Robert D Simari, Alan T Hirsch
BACKGROUND: Atherosclerotic peripheral artery disease affects 8% to 12% of Americans >65 years of age and is associated with a major decline in functional status, increased myocardial infarction and stroke rates, and increased risk of ischemic amputation. Current treatment strategies for claudication have limitations. PACE (Patients With Intermittent Claudication Injected With ALDH Bright Cells) is a National Heart, Lung, and Blood Institute-sponsored, randomized, double-blind, placebo-controlled, phase 2 exploratory clinical trial designed to assess the safety and efficacy of autologous bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in patients with peripheral artery disease and to explore associated claudication physiological mechanisms...
April 11, 2017: Circulation
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