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C Caldwell

D Caldwell Hahn, John C Wingfield, David M Fox, Brian G Walker, Jill E Thomley
In the coevolutionary dynamic of avian brood parasites and their hosts, maternal (or transgenerational) effects have rarely been investigated. We examined the potential role of elevated yolk testosterone in eggs of the principal brood parasite in North America, the brown-headed cowbird, and three of its frequent host species. Elevated maternal androgens in eggs are a common maternal effect observed in many avian species when breeding conditions are unfavorable. These steroids accelerate embryo development, shorten incubation period, increase nestling growth rate, and enhance begging vigor, all traits that can increase the survival of offspring...
October 13, 2016: General and Comparative Endocrinology
Lorraine Lau, Zubaida Al-Ismaili, Maya Harel-Sterling, Michael Pizzi, Jillian S Caldwell, Melissa Piccioni, Larry C Lands, Theresa Mottes, Prasad Devarajan, Stuart L Goldstein, Michael R Bennett, Michael Zappitelli
BACKGROUND: Serum cystatin C (CysC) is a more accurate glomerular filtration rate marker than serum creatinine (SCr) and may rise more quickly with acute kidney injury (AKI). METHODS: We performed a prospective cohort study of 81 non-critically ill children during 110 aminoglycoside (AG) treatments. We calculated area under the curve (AUC) for CysC to diagnose SCr-defined AKI and predict persistent AKI. SCr-AKI definition was based on the Kidney Disease: Improving Global Outcomes (≥stage 1: ≥50 % or 26...
October 14, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Shaoxiao Wang, Siyuan Zhang, Chuan Xu, Addie Barron, Floyd Galiano, Dhaval Patel, Yong Joo Lee, Guy A Caldwell, Kim A Caldwell, Stephan N Witt
We have been investigating the role that phosphatidylethanolamine (PE) and phosphatidylcholine (PC) content plays in modulating the solubility of the Parkinson's disease protein alpha-synuclein (α-syn) using Saccharomyces cerevisiae and Caenorhabditis elegans. One enzyme that synthesizes PE is the conserved enzyme phosphatidylserine decarboxylase (Psd1/yeast; PSD-1/worms), which is lodged in the inner mitochondrial membrane. We previously found that decreasing the level of PE due to knockdown of Psd1/psd-1 affects the homeostasis of α-syn in vivo...
2016: PloS One
Guang Gao, Anthony S Clare, Craig Rose, Gary S Caldwell
The incidence and severity of extraordinary macroalgae blooms (green tides) are increasing. Here, climate change (ocean warming and acidification) impacts on life history and biochemical responses of a causative green tide species, Ulva rigida, were investigated under combinations of pH (7.95, 7.55, corresponding to lower and higher pCO2), temperature (14, 18°C) and nitrate availability (6 and 150μmolL(-1)). The higher temperature accelerated the onset and magnitude of gamete settlement. Any two factor combination promoted germination and accelerated growth in young plants...
October 10, 2016: Marine Pollution Bulletin
G Farha, L Chin, A Dhillon, S Lim-Reinders, J Cifuentes Gaitan, T D Conrad, D Brotherston, C Caldwell, J Lee, I Karam, I Poon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Jenson Qi, Wensheng Lang, Margery A Connelly, Fuyong Du, Yin Liang, Gary W Caldwell, Tonya Martin, Michael K Hansen, Gee-Hong Kuo, Michael D Gaul, Alessandro Pocai, Seunghun Lee
Monoacylglycerol acyltransferase 2 (MGAT2) catalyzes the synthesis of diacylglycerol (DAG) from free fatty acids (FFA) and sn-monoacylglycerol (MG), the two major hydrolysis products of dietary fat. To demonstrate MGAT2-mediated cellular activity of triglyceride (TG) synthesis, we utilized 1-oleoyl-glycerol-d5 as a substrate to trace MGAT2-driven 1-oleoyl-glycerol-d5 incorporation into TG in HEK293 cells stably expressing human MGAT2. The oleoyl-glycerol-d5 incorporated major TG species were then quantified by liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI/MS/MS) in a 96-well format...
September 22, 2016: Analytical Biochemistry
Vincent J Alentado, Stephanie Caldwell, Heath P Gould, Michael P Steinmetz, Edward C Benzel, Thomas E Mroz
BACKGROUND CONTEXT: Multiple studies have determined minimum clinically important difference (MCID) thresholds for EuroQOL-5 Dimensions (EQ-5D) scores in lumbar fusion patients. However, a comprehensive understanding of predictors for a CSI postoperatively does not exist. PURPOSE: To determine medical, radiographic and surgical predictors for obtaining a clinically significant improvement (CSI) following lumbar fusion surgery. STUDY DESIGN: Retrospective Review...
September 21, 2016: Spine Journal: Official Journal of the North American Spine Society
J C Morales-Medina, T Iannitti, A Freeman, H K Caldwell
In rodents, the removal of the olfactory bulbs (OB), i.e. olfactory bulbectomy (OBX), results in numerous alterations in neurotransmitter, endocrine and immunologic systems, as well as behavioral changes, similar to those observed in depressed patients. Because the behavioral deficits induced in OBX animals are reversed after repeated administration of antidepressants, this is a model often used to test the effectiveness of putative antidepressant agents. Recent evidence suggests that OBX results in the dysfunction of various cellular processes within the hippocampus, including decrease in dentate gyrus neurogenesis, disruption in long term potentiation (LTP) in CA1 and CA3 subregions and neuronal atrophy in the CA1 subregion, along with downstream markers, all of which are consistent with abnormal neuronal activity in the hippocampus of clinically depressed populations...
September 12, 2016: Behavioural Brain Research
Charles S Fuchs, Josep Tabernero, Jiří Tomášek, Ian Chau, Bohuslav Melichar, Howard Safran, Mustapha A Tehfe, Dumitru Filip, Eldar Topuzov, Luis Schlittler, Anghel Adrian Udrea, William Campbell, Stephen Brincat, Michael Emig, Symantha A Melemed, Rebecca R Hozak, David Ferry, C William Caldwell, Jaffer A Ajani
BACKGROUND: Angiogenesis inhibition is an important strategy for cancer treatment. Ramucirumab, a human IgG1 monoclonal antibody that targets VEGF receptor 2 (VEGFR2), inhibits VEGF-A, -C, -D binding and endothelial cell proliferation. To attempt to identify prognostic and predictive biomarkers, retrospective analyses were used to assess tumour (HER2, VEGFR2) and serum (VEGF-C and -D, and soluble (s) VEGFR1 and 3) biomarkers in phase 3 REGARD patients with metastatic gastric/gastroesophageal junction carcinoma...
October 11, 2016: British Journal of Cancer
Chase T Ellis, Joseph G Tischler, Orest J Glembocki, Francisco J Bezares, Alexander J Giles, Richard Kasica, Loretta Shirey, Jeffrey C Owrutsky, Dmitry N Chigrin, Joshua D Caldwell
Polar dielectrics have garnered much attention as an alternative to plasmonic metals in the mid- to long-wave infrared spectral regime due to their low optical losses. As such, nanoscale resonators composed of these materials demonstrate figures of merit beyond those achievable in plasmonic equivalents. However, until now, only low-order, phonon-mediated, localized polariton resonances, known as surface phonon polaritons (SPhPs), have been observed in polar dielectric optical resonators. In the present work, we investigate the excitation of 16 distinct high-order, multipolar, localized surface phonon polariton resonances that are optically excited in rectangular pillars etched into a semi-insulating silicon carbide substrate...
2016: Scientific Reports
Shawn D Flanagan, Tunde K Szivak, William H DuPont, Lydia K Caldwell, Emily C Barnhart, Emily C Borden, Catherine Saenz, Robert S Staron, Wesley C Hymer, Bradley C Nindl, William J Kraemer
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Asbjørg Stray-Pedersen, Hanne Sørmo Sorte, Pubudu Samarakoon, Tomasz Gambin, Ivan K Chinn, Zeynep H Coban Akdemir, Hans Christian Erichsen, Lisa R Forbes, Shen Gu, Bo Yuan, Shalini N Jhangiani, Donna M Muzny, Olaug Kristin Rødningen, Ying Sheng, Sarah K Nicholas, Lenora M Noroski, Filiz O Seeborg, Carla M Davis, Debra L Canter, Emily M Mace, Timothy J Vece, Carl E Allen, Harshal A Abhyankar, Philip M Boone, Christine R Beck, Wojciech Wiszniewski, Børre Fevang, Pål Aukrust, Geir E Tjønnfjord, Tobias Gedde-Dahl, Henrik Hjorth-Hansen, Ingunn Dybedal, Ingvild Nordøy, Silje F Jørgensen, Tore G Abrahamsen, Torstein Øverland, Anne Grete Bechensteen, Vegard Skogen, Liv T N Osnes, Mari Ann Kulseth, Trine E Prescott, Cecilie F Rustad, Ketil R Heimdal, John W Belmont, Nicholas L Rider, Javier Chinen, Tram N Cao, Eric A Smith, Maria Soledad Caldirola, Liliana Bezrodnik, Saul Oswaldo Lugo Reyes, Francisco J Espinosa Rosales, Nina Denisse Guerrero-Cursaru, Luis Alberto Pedroza, Cecilia M Poli, Jose L Franco, Claudia M Trujillo Vargas, Juan Carlos Aldave Becerra, Nicola Wright, Thomas B Issekutz, Andrew C Issekutz, Jordan Abbott, Jason W Caldwell, Diana K Bayer, Alice Y Chan, Alessandro Aiuti, Caterina Cancrini, Eva Holmberg, Christina West, Magnus Burstedt, Ender Karaca, Gözde Yesil, Hasibe Artac, Yavuz Bayram, Mehmed Musa Atik, Mohammad K Eldomery, Mohammad S Ehlayel, Stephen Jolles, Berit Flatø, Alison A Bertuch, I Celine Hanson, Victor W Zhang, Lee-Jun Wong, Jianhong Hu, Magdalena Walkiewicz, Yaping Yang, Christine M Eng, Eric Boerwinkle, Richard A Gibbs, William T Shearer, Robert Lyle, Jordan S Orange, James R Lupski
BACKGROUND: Primary immunodeficiency diseases (PIDDs) are clinically and genetically heterogeneous disorders thus far associated with mutations in more than 300 genes. The clinical phenotypes derived from distinct genotypes can overlap. Genetic etiology can be a prognostic indicator of disease severity and can influence treatment decisions. OBJECTIVE: We sought to investigate the ability of whole-exome screening methods to detect disease-causing variants in patients with PIDDs...
July 16, 2016: Journal of Allergy and Clinical Immunology
Shu-Wei Yang, Jianping Pan, Christine Yang, Marc Labroli, Weidong Pan, John Caldwell, Sookhee Ha, Sandra Koseoglu, Jing C Xiao, Todd Mayhood, Payal R Sheth, Charles G Garlisi, Jin Wu, Sang Ho Lee, Hao Wang, Christopher M Tan, Terry Roemer, Jing Su
A series of benzimidazole analogs have been synthesized to improve the profile of the previous lead compounds tarocin B and 1. The syntheses, structure-activity relationships, and selected biochemical data of these analogs are described. The optimization efforts allowed the identification of 21, a fluoro-substituted benzimidazole, exhibiting potent TarO inhibitory activity and typical profile for a wall teichoic acid (WTA) biosynthesis inhibitor. Compound 21 displayed a potent synergistic and bactericidal effect in combination with imipenem against diverse methicillin-resistant Staphylococci...
October 1, 2016: Bioorganic & Medicinal Chemistry Letters
Aaron R Caldwell, Matthew A Tucker, Cory L Butts, Brendon P McDermott, Jakob L Vingren, Laura J Kunces, Elaine C Lee, Colleen X Munoz, Keith Williamson, Lawrence E Armstrong, Matthew S Ganio
Caffeine can reduce muscle pain during exercise; however the efficacy of caffeine in improving muscle soreness and recovery from a demanding long-duration exercise bout has not been established. The purpose of this study was to investigate the effects of caffeine intake on ratings of perceived muscle soreness (RPMS) and perceived lower extremity functionality (LEF) following the completion of a 164-km endurance cycling event. Prior to and after cycling RPMS (1-to-6; 6=severe soreness) and LEF (0-to-80; 80=full functionality) were assessed via questionnaires...
August 19, 2016: Journal of Strength and Conditioning Research
Holly Edwards, Mara Rubenstein, Alan A Dombkowski, J Timothy Caldwell, Roland Chu, Ana C Xavier, Ryan Thummel, Melody Neely, Larry H Matherly, Yubin Ge, Jeffrey W Taub
In this study we sought to identify genetic factors associated with the presenting white blood cell (WBC) count in B-precursor acute lymphoblastic leukemia (BP-ALL). Using ETV6-RUNX1-positive BP-ALL patient samples, a homogeneous subtype, we identified 16 differentially expressed genes based on the presenting WBC count (< 50,000/cumm vs > 50,000). We further confirmed that IL1R1, BCAR3, KCNH2, PIR, and ZDHHC23 were differentially expressed in a larger cohort of ETV6-RUNX1-negative BP-ALL patient samples...
2016: PloS One
Praveen Ganesh, Rohan P Raut, Kiran Kumar Boyina, Samarth Shetty, Paul C Salins
Ossifying fibroma is a rare benign osteogenic neoplasm arising from undifferentiated cells of the periodontal ligament. Ossifying fibroma have a well-defined border that differentiates it from fibrous dysplasia clinically; these tumors manifest as a round or ovoid, expansile, painless, slow-growing mass may displace the roots of adjacent teeth and also cause root resorption. A variety of approaches for resection of the maxilla have been described. Most involve the use of facial and lip-splitting incisions to gain wide access...
October 2016: Journal of Craniofacial Surgery
Samira Bahrainy, Wayne C Levy, Janet M Busey, James H Caldwell, John R Stratton
INTRODUCTION: Resting heart rate (RHR) declines with exercise training. Possible mechanisms include: 1) increased parasympathetic tone, 2) decreased responsiveness to beta-adrenergic stimulation, 3) decreased intrinsic heart rate or 4) combination of these factors. OBJECTIVE: To determine whether an increase in resting parasympathetic tone or decrease in response to beta-adrenergic stimulation contributes to the decrease in RHR with training. METHODS: 51 screened healthy subjects aged 18-32 (n=20, mean age 26, 11 female) or 65-80 (n=31, mean age 69, 16 female) were tested before and after 6months of supervised exercise training...
November 1, 2016: International Journal of Cardiology
G S Bondy, L Coady, I Curran, D Caldwell, C Armstrong, S A Aziz, A Nunnikhoven, A M Gannon, V Liston, J Shenton, R Mehta
Deoxynivalenol (DON) is a secondary metabolite associated with Fusarium species pathogenic to important food crops. A two-year feeding study reported that DON was non-carcinogenic in B6C3F1 mice. The present study was conducted to further characterize the chronic effects of DON by exposing cancer-prone transgenic p53 heterozygous (p53+/-) male mice and p53 homozygous (p53+/+) male mice to 0, 1, 5, or 10 mg DON/kg in diet for 26 weeks. Gross and microscopic organ-specific neoplastic and non-neoplastic changes and expression profiles of key hepatic and renal genes were assessed...
October 2016: Food and Chemical Toxicology
Soung Min Kim, Mi Young Eo, Yun Ju Cho, Yeon Sook Kim, Suk Keun Lee
Both maxillary sinusitis (MS) and maxillary retention cyst (MRC) involve the maxillary sinus and show similar clinical features. Clinically, differentiating between MS and MRC is sometimes difficult in asymptomatic patients, despite their quite different pathogenic behaviors. To identify differential protein expressions in the secretory fluids of MS and MRC, 25 cases of asymptomatic MS and 15 cases of asymptomatic MRC were examined pathologically in this study. All patients underwent routine endoscopic sinus surgery or modified Caldwell-Luc procedure and the sinus mucosal specimens obtained during these procedures with the approval of the Institutional Review Board...
July 15, 2016: European Archives of Oto-rhino-laryngology
Teresa C Rice, Aaron P Seitz, Michael J Edwards, Erich Gulbins, Charles C Caldwell
Burn patients with concomitant pulmonary Pseudomonas aeruginosa (PA) infection have mortality rates as high as 50%, despite antibiotic therapy. Sphingosine is generated from ceramide via ceramidase and has been reported to have antimicrobial properties. We observed a reduction in sphingosine and a concurrent increase in ceramide in bronchial epithelial cells after burn injury. After PA inoculation, these mice had a significant decrease in survival compared to noninjured mice. However, when injured mice were pretreated with sphingosine or neutral ceramidase and subsequently infected, mortality and bacterial levels were robustly reduced...
July 14, 2016: Journal of Leukocyte Biology
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