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C Caldwell

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https://www.readbyqxmd.com/read/28735604/measuring-home-environments-across-cultures-invariance-of-the-home-scale-across-eight-international-sites-from-the-mal-ed-study
#1
Paul C Jones, Laura L Pendergast, Barbara A Schaefer, Muneera Rasheed, Erling Svensen, Rebecca Scharf, Rita Shrestha, Angelina Maphula, Reeba Roshan, Zeba Rasmussen, Jessica C Seidman, Laura E Murray-Kolb
The home environment provides the context for much of a child's early development. Examples of important aspects of the home environment include safety, cleanliness, and opportunities for cognitive stimulation. This study sought to examine the psychometric properties of an adapted form of the Home Observation for the Measurement of the Environment (HOME; Caldwell & Bradley, 1984, 2003) across the eight international sites of the MAL-ED project (Dhaka, Bangladesh; Vellore, India; Bhakatapur, Nepal; Naushahro Feroze, Pakistan; Fortaleza, Brazil; Loreto, Peru; Venda, South Africa; Haydom, Tanzania), to identify a factor structure that fit the data at all sites, and to derive a subset of items that could be used to examine home environmental characteristics across sites...
October 2017: Journal of School Psychology
https://www.readbyqxmd.com/read/28708968/rv3723-luca-coordinates-fatty-acid-and-cholesterol-uptake-in-mycobacterium-tuberculosis
#2
Evgeniya V Nazarova, Christine R Montague, Thuy La, Kaley M Wilburn, Neelima Sukumar, Wonsik Lee, Shannon Caldwell, David G Russell, Brian C VanderVen
Pathogenic bacteria have evolved highly specialized systems to extract essential nutrients from their hosts. Mycobacterium tuberculosis (Mtb) scavenges lipids (cholesterol and fatty acids) to maintain infections in mammals but mechanisms and proteins responsible for the import of fatty acids in Mtb were previously unknown. Here, we identify and determine that the previously uncharacterized protein Rv3723/LucA, functions to integrate cholesterol and fatty acid uptake in Mtb. Rv3723/LucA interacts with subunits of the Mce1 and Mce4 complexes to coordinate the activities of these nutrient transporters by maintaining their stability...
June 27, 2017: ELife
https://www.readbyqxmd.com/read/28699548/when-communities-are-really-in-control-ethical-issues-surrounding-community-mobilisation-for-dengue-prevention-in-mexico-and-nicaragua
#3
REVIEW
Robert J Ledogar, Carlos Hernández-Alvarez, Amy C Morrison, Jorge Arosteguí, Arcadio Morales-Perez, Elizabeth Nava-Aguilera, José Legorreta-Soberanis, Dawn Caldwell, Josefina Coloma, Eva Harris, Neil Andersson
We discuss two ethical issues raised by Camino Verde, a 2011-2012 cluster-randomised controlled trial in Mexico and Nicaragua, that reduced dengue risk though community mobilisation. The issues arise from the approach adopted by the intervention, one called Socialisation of Evidence for Participatory Action. Community volunteer teams informed householders of evidence about dengue, its costs and the life-cycle of Aedes aegypti mosquitoes, while showing them the mosquito larvae in their own water receptacles, without prescribing solutions...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28697107/relationship-between-labor-and-delivery-unit-management-practices-and-maternal-outcomes
#4
Avery C Plough, Grace Galvin, Zhonghe Li, Stuart R Lipsitz, Shehnaz Alidina, Natalie J Henrich, Lisa R Hirschhorn, William R Berry, Atul A Gawande, Doris Peter, Rory McDonald, Donna L Caldwell, Janet H Muri, Debra Bingham, Aaron B Caughey, Eugene R Declercq, Neel T Shah
OBJECTIVE: To define, measure, and characterize key competencies of managing labor and delivery units in the United States and assess the associations between unit management and maternal outcomes. METHODS: We developed and administered a management measurement instrument using structured telephone interviews with both the primary nurse and physician managers at 53 diverse hospitals across the United States. A trained interviewer scored the managers' interview responses based on management practices that ranged from most reactive (lowest scores) to most proactive (highest scores)...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28690205/bronchoalveolar-lavage-microvesicles-protect-burn-injured-mice-from-pulmonary-infection
#5
Teresa C Rice, Amanda M Pugh, Brent T Xia, Aaron P Seitz, Brynne E Whitacre, Erich Gulbins, Charles C Caldwell
BACKGROUND: Pseudomonas aeruginosa (PA) is a major cause of morbidity and mortality among burn patients, despite antibiotic therapy. There is a need to identify innate immune defenses that prevent PA infection in injured adults in an effort to find therapeutic alternatives to antibiotics. Here, we tested our hypothesis that Microvesicles (MVs) in bronchoalveolar (BAL) fluid have a role in the immunity of the lung in response to pathogens. STUDY DESIGN: MVs were isolated from murine BAL fluid, quantified using nanoparticle tracking analysis, and injected into burn injured mice prior to PA infection...
July 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28688660/impact-of-tranexamic-acid-on-coagulation-and-inflammation-in-murine-models-of-traumatic-brain-injury-and-hemorrhage
#6
Ryan M Boudreau, Mark Johnson, Rosalie Veile, Lou Ann Friend, Holly Goetzman, Timothy A Pritts, Charles C Caldwell, Amy T Makley, Michael D Goodman
BACKGROUND: Posttraumatic coagulopathy and inflammation can exacerbate secondary cerebral damage after traumatic brain injury (TBI). Tranexamic acid (TXA) has been shown clinically to reduce mortality in hemorrhaging and head-injured trauma patients and has the potential to mitigate secondary brain injury with its reported antifibrinolytic and antiinflammatory properties. We hypothesized that TXA would improve posttraumatic coagulation and inflammation in a murine model of TBI alone and in a combined injury model of TBI and hemorrhage (TBI/H)...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28685690/can-untargeted-metabolomics-be-utilized-in-drug-discovery-development
#7
G Caldwell, Gregory C Leo
Untargeted metabolomics is a promising approach for reducing the significant attrition rate for discovering and developing drugs in the pharmaceutical industry. This review aims to highlight the practical decision-making value of untargeted metabolomics for the advancement of drug candidates in drug discovery/development including potentially identifying and validating novel therapeutic targets, creating alternative screening paradigms, facilitating the selection of specific and translational metabolite biomarkers, identifying metabolite signatures for the drug efficacy mechanism of action, and understanding potential drug-induced toxicity...
July 7, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28685447/diet-induced-ketosis-protects-against-focal-cerebral-ischemia-in-mouse
#8
Kui Xu, Lena Ye, Katyayini Sharma, Yongming Jin, Matthew M Harrison, Tylor Caldwell, Jessica M Berthiaume, Yu Luo, Joseph C LaManna, Michelle A Puchowicz
Over the past decade we have consistently shown that ketosis is neuroprotective against ischemic insults in rats. We reported that diet-induced ketotic rats had a significant reduction in infarct volume when subjected to middle cerebral artery occlusion (MCAO), and improved survival and recovery after cardiac arrest and resuscitation. The neuroprotective mechanisms of ketosis (via ketogenic diet; KG) include (i) ketones are alternate energy substrates that can restore energy balance when glucose metabolism is deficient and (ii) ketones modulate cell-signalling pathways that are cytoprotective...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28682945/chronic-critical-illness-and-persistent-inflammation-what-can-we-learn-from-the-elderly-injured-septic-and-malnourished
#9
Vanessa Nomellini, Lewis J Kaplan, Carrie A Sims, Charles C Caldwell
Patients in the intensive care unit (ICU) who develop chronic critical illness significantly stress the clinical capacity and financial resources of healthcare systems. Although vast improvements have been made in critical care management, outcomes for this ICU subset remains poor. A hallmark for patients who progress to chronic critical illness is the development of persistent inflammation and immunosuppression. The risk factors associated with the development of chronic critical illness include increased age, medical comorbidities, severe injury, septic shock, and malnutrition...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682931/understanding-anthropometric-characteristics-associated-with-performance-in-manual-lifting-tasks
#10
Ben Beck, Kane J Middleton, Daniel C Billing, Joanne N Caldwell, Greg L Carstairs
Manual lifting is an essential military job task and is commonly linked to occupational injury. Methods to reduce injury risk focus on ensuring that employees have the requisite physical capacity to safely conduct critical job tasks. The aim of this study was to investigate which anthropometric characteristics are associated with lifting performance to inform targeted training programs for job critical lifting tasks. Sixty-three (42 males and 21 females) participants conducted three maximal lifts to a platform (pack lift to 1...
July 3, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28673825/the-medico-legal-landscape-of-spine-surgery-how-do-surgeons-fare
#11
Melvin C Makhni, Paul J Park, Jesus Jimenez, Comron S Saifi, Jon-Michael Caldwell, Alex Ha, Bianca Figueroa-Santana, Ronald A Lehman, Mark Weidenbaum
BACKGROUND CONTEXT: Due to the limited and confidential nature of most legal data, scarce literature is available to physicians about reasons for litigation in spine surgery. In order to optimally compensate patients while protecting physicians, further understanding of the medico-legal landscape is needed for high-risk procedures such as spine surgery. Based on these, surgeons can explore ways to better protect both their patients and themselves. PURPOSE: To characterize the current medico-legal environment of spine surgery by analyzing a recent dataset of malpractice litigation...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28650928/circulating-exosomes-isolated-from-septic-mice-induce-cardiovascular-hyperpermeability-through-promoting-podosome-cluster-formation
#12
Xingjiang Mu, Xiaohong Wang, Wei Huang, Rui-Tao Wang, Kobina Essandoh, Yutian Li, Amanda M Pugh, Jiangtong Peng, Shan Deng, Yigang Wang, Charles C Caldwell, Tianqing Peng, Kai-Jiang Yu, Guo-Chang Fan
Septic shock increases vascular permeability, leading to multiple organ failure including cardiac dysfunction, a major contributor to septic death. Podosome, an actin-based dynamic membrane structure, plays critical roles in extracellular matrix degradation and angiogenesis. However, whether podosome contributes to endothelial barrier dysfunction during septic shock remains unknown. In this study, we found that the endothelial hyperpermeability, stimulated by PMA and thrombin, was accompanied by increased formation of podosome clusters at the cell periphery, indicating a positive correlation between podosome clusters and endothelial leakage...
June 23, 2017: Shock
https://www.readbyqxmd.com/read/28632958/decreased-portal-vein-velocity-is-predictive-of-the-development-of-portal-vein-thrombosis-a-matched-case-control-study
#13
Jonathan G Stine, Jennifer Wang, Puja M Shah, Curtis K Argo, Nicolas Intagliata, Andre Uflacker, Stephen H Caldwell, Patrick G Northup
BACKGROUND & AIMS: Portal vein thrombosis (PVT) in cirrhosis may lead to hepatic decompensation and increased mortality. We aimed to investigate if decreased portal vein (PV) velocity is associated with future PVT. METHODS: Data on adult patients with cirrhosis and PVT between January 1, 2005 and July 30, 2015 were obtained. Cases with PVT were matched by age, gender and Model for End stage Liver Disease (MELD) score to corresponding controls without PVT. Cox proportional hazards models, receiver operator curves and Kaplan Meier curves were constructed...
June 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28619715/liquefied-gas-electrolytes-for-electrochemical-energy-storage-devices
#14
Cyrus S Rustomji, Yangyuchen Yang, Tae Kyoung Kim, Jimmy Mac, Young Jin Kim, Elizabeth Caldwell, Hyeseung Chung, Y Shirley Meng
Electrochemical capacitors and Li-ion batteries have seen little change in their electrolyte chemistry since their commercialization which has limited improvements in device performance. Combining superior physical and chemical properties and a high dielectric-fluidity factor, the use of electrolytes based on solvent systems which exclusively use components which are typically gaseous under standard conditions show a wide potential window of stability and excellent performance over an extended temperature range...
June 15, 2017: Science
https://www.readbyqxmd.com/read/28612122/effect-of-passive-heat-stress-and-exercise-in-the-heat-on-arterial-stiffness
#15
Aaron R Caldwell, Forrest B Robinson, Matthew A Tucker, Cash H Arcement, Cory L Butts, Brendon P McDermott, Matthew S Ganio
PURPOSE: Prior evidence indicates that acute heat stress and aerobic exercise independently reduce arterial stiffness. The combined effects of exercise and heat stress on PWV are unknown. The purpose of this study was to determine the effects of heat stress with passive heating and exercise in the heat on arterial stiffness. METHODS: Nine participants (n = 3 females, 47 ± 11 years old; 24.1 ± 2.8 kg/m(2)) completed four trials. In a control trial, participants rested supine (CON)...
August 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28552668/%C3%AE-1-integrin-accumulates-in-cystic-fibrosis-luminal-airway-epithelial-membranes-and-decreases-sphingosine-promoting-bacterial-infections
#16
Heike Grassmé, Brian Henry, Regan Ziobro, Katrin Anne Becker, Joachim Riethmüller, Aaron Gardner, Aaron P Seitz, Joerg Steinmann, Stephan Lang, Christopher Ward, Edward H Schuchman, Charles C Caldwell, Markus Kamler, Michael J Edwards, Malcolm Brodlie, Erich Gulbins
Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients with cystic fibrosis (CF). We observed that β1-integrins accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans with CF. β1-integrin accumulation is due to increased ceramide and the formation of ceramide platforms that trap β1-integrins on the luminal pole of bronchial epithelial cells. β1-integrins downregulate acid ceramidase expression, resulting in further accumulation of ceramide and consequent reduction of surface sphingosine, a lipid that kills bacteria...
June 14, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28501227/integrative-medicine-strategies-for-changing-health-behaviors-support-for-primary-care
#17
REVIEW
Ruth Q Wolever, Karen L Caldwell, Lindsey C McKernan, Marni G Hillinger
Until system reforms allow adequate time and reimbursement for primary care providers to focus on lifestyle change to prevent and mitigate chronic disease, primary care providers need a manageable, defined role to support lifestyle change. The authors suggest this role is to serve as a catalyst, priming the patient for change; educating and pointing the patient to appropriate, evidence-based resources for additional guidance and hands-on support; and providing ongoing encouragement throughout the long journey of change while patients work more intensely with health coaches or allied health providers...
June 2017: Primary Care
https://www.readbyqxmd.com/read/28493607/rhodium-catalyzed-addition-of-aryl-boronic-acids-to-2-2-disubstituted-malononitriles
#18
Christian A Malapit, Donald R Caldwell, Irungu K Luvaga, Jonathan T Reeves, Ivan Volchkov, Nina C Gonnella, Zhengxu S Han, Carl A Busacca, Amy R Howell, Chris H Senanayake
β-Ketonitriles bearing a quaternary carbon at the 2-position were prepared through Rh-catalyzed addition of aryl boronic acids to 2,2-disubstituted malononitriles. In contrast to the previously described transnitrilative cyanation of aryl boronic acids with dialkylmalononitriles, the present reaction avoids retro-Thorpe collapse of the intermediate addition product through the use of a milder base. The reaction was amenable to a variety of aryl boronic acids and disubstituted malononitriles, providing a diverse array of β-ketonitriles...
May 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28479217/physiological-and-psychological-effects-of-testosterone-during-severe-energy-deficit-and-recovery-a-study-protocol-for-a-randomized-placebo-controlled-trial-for-optimizing-performance-for-soldiers-ops
#19
Stefan M Pasiakos, Claire E Berryman, J Philip Karl, Harris R Lieberman, Jeb S Orr, Lee M Margolis, John A Caldwell, Andrew J Young, Monty A Montano, William J Evans, Oshin Vartanian, Owen T Carmichael, Kishore M Gadde, Melissa Harris, Jennifer C Rood
BACKGROUND: The physiological consequences of severe energy deficit include hypogonadism and the loss of fat-free mass. Prolonged energy deficit also impacts physical performance, mood, attentiveness, and decision-making capabilities. This study will determine whether maintaining a eugonadal state during severe, sustained energy deficit attenuates physiological decrements and maintains mental performance. This study will also assess the effects of normalizing testosterone levels during severe energy deficit and recovery on gut health and appetite regulation...
July 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28474933/new-limits-on-bosonic-dark-matter-solar-axions-pauli-exclusion-principle-violation-and-electron-decay-from-the-majorana-demonstrator
#20
N Abgrall, I J Arnquist, F T Avignone, A S Barabash, F E Bertrand, A W Bradley, V Brudanin, M Busch, M Buuck, T S Caldwell, Y-D Chan, C D Christofferson, P-H Chu, C Cuesta, J A Detwiler, C Dunagan, Yu Efremenko, H Ejiri, S R Elliott, T Gilliss, G K Giovanetti, J Goett, M P Green, J Gruszko, I S Guinn, V E Guiseppe, C R S Haufe, R Henning, E W Hoppe, S Howard, M A Howe, B R Jasinski, K J Keeter, M F Kidd, S I Konovalov, R T Kouzes, A M Lopez, J MacMullin, R D Martin, R Massarczyk, S J Meijer, S Mertens, C O'Shaughnessy, A W P Poon, D C Radford, J Rager, A L Reine, K Rielage, R G H Robertson, B Shanks, M Shirchenko, A M Suriano, D Tedeschi, J E Trimble, R L Varner, S Vasilyev, K Vetter, K Vorren, B R White, J F Wilkerson, C Wiseman, W Xu, E Yakushev, C-H Yu, V Yumatov, I Zhitnikov, B X Zhu
We present new limits on exotic keV-scale physics based on 478 kg d of Majorana Demonstrator commissioning data. Constraints at the 90% confidence level are derived on bosonic dark matter (DM) and solar axion couplings, Pauli exclusion principle violating (PEPV) decay, and electron decay using monoenergetic peak signal limits above our background. Our most stringent DM constraints are set for 11.8 keV mass particles, limiting g_{Ae}<4.5×10^{-13} for pseudoscalars and (α^{'}/α)<9.7×10^{-28} for vectors...
April 21, 2017: Physical Review Letters
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