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anemia AND memory AND children

Somashekhar Marutirao Nimbalkar, Dipen Vasudev Patel, Ajay Gajanan Phatak
OBJECTIVE: Micronutrient deficiencies can lead to anemia, growth restriction, and poor motor and cognitive development. A clinical trial was planned to assess the impact of nutritional supplementation on cognitive measures in preschool children. Conducting clinical trials in children is difficult due to underlying laws, hesitation of the research community, and difficult enrollment. We carried out a questionnaire-based feasibility survey to assess the interest of parents towards participation in such a nutrition-based study...
2016: PloS One
Olubusola B Oluwole, Robert B Noll, Daniel G Winger, Olu Akinyanju, Enrico M Novelli
BACKGROUND: Cognitive impairment is a major neurological complication of sickle cell anemia (SCA) in the United States, but there are limited studies of cognitive impairment in Nigeria, the country with the highest SCA burden. We hypothesized that children from Nigeria with SCA have worse cognitive functioning than comparison children and explored the association between lower cognitive functioning and key laboratory demographic and socioeconomic variables among children with SCA. PROCEDURE: We conducted a cross-sectional survey, supplemented by anthropomorphic and laboratory data, among a convenience sample of children from Nigeria with and without SCA...
November 2016: Pediatric Blood & Cancer
Gauthamen Rajendran, Padinharath Krishnakumar, Moosa Feroze, Veluthedath Kuzhiyil Gireeshan
OBJECTIVE: To study the cognitive functions and psychological problems in children with Sickle cell anemia (SCA). METHODS: Children with SCA were compared with an age, sex- and community- matched control group of children with no SCA. Malins Intelligence Scale for Indian children, modified PGI memory scale, and Childhood Psychopathology Measurement Schedule were used to assess cognitive functions and psychological problems. RESULTS: Verbal quotient, performance quotient and intelligence quotient in SCA group were 77, 81, 78, respectively versus 92, 95, 93, respectively in non-SCA group (P <0...
June 8, 2016: Indian Pediatrics
Palittiya Sintusek, Voranush Chongsrisawat, Yong Poovorawan
OBJECTIVE: Wilson's disease (WD) is a rare autosomal recessive disorder characterized by copper accumulation. Clinical presentations are extraordinarily diverse, and currently no single diagnostic test can confirm WD with high accuracy. A complete understanding of the presentations and improved diagnostic methods are important for disease management. The authors' aimed to examine disease characteristics, management, and treatment outcome of WD in children, especially when genetic analysis and liver copper measurements were limited...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Wilson L Mandala, Chisomo L Msefula, Esther N Gondwe, James J Gilchrist, Stephen M Graham, Paul Pensulo, Grace Mwimaniwa, Meraby Banda, Terrie E Taylor, Elizabeth E Molyneux, Mark T Drayson, Steven A Ward, Malcolm E Molyneux, Calman A MacLennan
Lymphocytes are implicated in immunity and pathogenesis of severe malaria. Since lymphocyte subsets vary with age, assessment of their contribution to different etiologies can be difficult. We immunophenotyped peripheral blood from Malawian children presenting with cerebral malaria, severe malarial anemia, and uncomplicated malaria (n = 113) and healthy aparasitemic children (n = 42) in Blantyre, Malawi, and investigated lymphocyte subset counts, activation, and memory status. Children with cerebral malaria were older than those with severe malarial anemia...
November 18, 2015: Clinical and Vaccine Immunology: CVI
Lindsay M Anderson, Taryn M Allen, Courtney D Thornburg, Melanie J Bonner
Children with sickle cell disease (SCD) report fatigue in addition to acute and chronic pain, which can decrease overall health-related quality of life (HRQL). The primary objective of the current study was to investigate the relationship between fatigue and HRQL. Given limited prior research, secondary objectives included investigation of associations between fatigue and functional outcomes, including child neurocognitive and social-emotional functioning. Children aged 8 to 16 years (N=32) and a caregiver completed measures of fatigue, HRQL, pain, and neurocognitive and social-emotional functioning...
November 2015: Journal of Pediatric Hematology/oncology
Ioannis Bakoyiannis, Eleana Gkioka, Afrodite Daskalopoulou, Laskarina-Maria Korou, Despina Perrea, Vasilios Pergialiotis
Iron deficiency (ID) is a major public health problem worldwide among children aged 0-12 months. Several factors seem to contribute to the iron-deficient state in infancy, including insufficient antenatal and neonatal iron supplementation, exclusive breastfeeding, and early umbilical cord clamping after birth. The most concerning complications of ID, except for anemia, are related to altered long-term neurodevelopment. Clinical studies have shown a negative impact of ID anemia on fetal and neonatal behavior including impairments of motor maturity, autonomic response, memory/learning, and mood...
2015: Reviews in the Neurosciences
Hylemariam Mihiretie, Bineyam Taye, Aster Tsegaye
Background. Anemia is one of the most commonly observed hematological abnormalities and an independent prognostic marker of HIV disease. The aim of this study was to determine the magnitude of anemia and associated factors among pediatric HIV/AIDS patients attending Zewditu Memorial Hospital (ZMH) ART Clinic in Addis Ababa, Ethiopia. Methods. A cross-sectional study was conducted among pediatric HIV/AIDS patients of Zewditu Memorial Hospital (ZMH) between August 05, 2013, and November 25, 2013. A total of 180 children were selected consecutively...
2015: Anemia
Hylemariam Mihiretie Mengist, Bineyam Taye, Aster Tsegaye
BACKGROUND: Intestinal parasites (IPs) are major concerns in most developing countries where HIV/AIDS cases are concentrated and almost 80% of AIDS patients die of AIDS-related infections. In the absence of highly active antiretroviral therapy (HAART), HIV/AIDS patients in developing countries unfortunately continue to suffer from the consequences of opportunistic and other intestinal parasites. The aim of the study was to determine the prevalence of intestinal parasites in relation to CD4+ T cells levels and anemia among HAART initiated and HAART naïve pediatric HIV patients in a Model ART center in Addis Ababa, Ethiopia...
2015: PloS One
Howard M Lederman, Margaret A Connolly, Ram Kalpatthi, Russell E Ware, Winfred C Wang, Lori Luchtman-Jones, Myron Waclawiw, Jonathan C Goldsmith, Andrea Swift, James F Casella
BACKGROUND AND OBJECTIVE: Susceptibility to encapsulated bacteria is well known in sickle cell disease (SCD). Hydroxyurea use is common in adults and children with SCD, but little is known about hydroxyurea's effects on immune function in SCD. Because hydroxyurea inhibits ribonucleotide reductase, causing cell cycle arrest at the G1-S interface, we postulated that hydroxyurea might delay transition from naive to memory T cells, with inhibition of immunologic maturation and vaccine responses...
October 2014: Pediatrics
Alecia J Leonard, Kerry A Chalmers, Clare E Collins, Amanda J Patterson
Rates of iron deficiency are high amongst healthy young women. Cognitive impairment occurs secondary to iron deficiency in infants and children, but evaluation of the impact on cognition among young women is inconsistent. The aim was to determine the suitability of the IntegNeuro test battery for assessing cognitive function in iron-deficient and iron-sufficient young women. A pilot double-blinded, placebo-controlled intervention trial was conducted in iron-deficient (serum ferritin ≤ 20 μg/L and haemoglobin > 120 g/L) and iron-sufficient young women (18-35 years)...
June 2014: Nutrients
Paul Bangirana, Robert O Opoka, Michael J Boivin, Richard Idro, James S Hodges, Regilda A Romero, Elsa Shapiro, Chandy C John
BACKGROUND: Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM <5 years of age, or in children with severe malarial anemia (SMA), a form of severe malaria estimated to affect as many as 5 million children annually. METHODS: Children <5 years of age presenting to Mulago Hospital, Kampala, Uganda, with CM (n = 80) or SMA (n = 86) were assessed for overall cognitive ability, attention, and associative memory 1 week after discharge and 6 and 12 months later...
August 1, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Mary Iampietro, Tania Giovannetti, Reem Tarazi
Children with sickle cell disease (SCD) suffer from systemic processes (e.g., chronic anemia, recurrent hypoxic-ischemic events, chronic inflammation) that have been associated with neurocognitive impairment in a range of clinical populations, but which have been largely understudied in relation to specific domains of cognitive functioning in children with SCD. This review focuses on episodic memory, as the hippocampus may be especially vulnerable to the systemic processes associated with SCD. The first part of the paper outlines the pathophysiology of SCD and briefly reviews the extant literature on academic and cognitive functioning in children with SCD, emphasizing the dearth of research on episodic memory...
June 2014: Neuropsychology Review
Ashley B Breton, Julia A Fox, Mary P Brownson, Matthew D McEchron
OBJECTIVES: Developmental iron deficiency (ID) has been shown to put children at risk for compromised learning and memory capacity, and it has also been shown to impair hippocampus-dependent forms of memory as well as hippocampal synaptic transmission. Catecholamines are known to play a pivotal role in memory consolidation, and studies have demonstrated that perinatal ID alters dopaminergic systems in various brain areas. It is not known, however, whether perinatal ID impairs dopaminergic synaptic plasticity in learning and memory structures such as the hippocampus...
August 2015: Nutritional Neuroscience
Florencia Lopez Boo, Giordano Palloni, Sergio Urzua
This paper estimates the cost-benefit ratio for an integrated early childhood development program in Nicaragua (PAININ). Using longitudinal data, we estimate the average treatment effects of PAININ including micronutrient sprinkles on the prevalence of anemia and hemoglobin levels among disadvantaged children aged 6-36 months. We also estimate the effects of PAININ excluding sprinkles on cognitive outcomes among children aged 2.5-5 years. In the younger age group the program reduced anemia by 4 percentage points after 8 months and nearly 6 percentage points after 1 year; the latter is a 26% decrease in anemia...
January 2014: Annals of the New York Academy of Sciences
Memorie Nichols, Aryeh D Stein, Judith Lupo Wold
OBJECTIVES: We evaluated the health status of migrant farmworkers' children served by the Farm Worker Family Health Program (FWFHP) in Moultrie, Georgia. METHODS: We analyzed data from children aged 0 to 16 years examined through the FWFHP from 2003 to 2011 (n across years = 179-415). We compared their prevalence of overweight, obesity, elevated blood pressure, anemia, and stunting with that of children in the United States and Mexico. RESULTS: Across study years, prevalence of overweight, obesity, elevated blood pressure, anemia, and stunting ranged from 13...
February 2014: American Journal of Public Health
Isaac Oludare Oluwayemi, Biobele Joackim Brown, Olusola Adetunji Oyedeji, Margaret Adefiola Oluwayemi
INTRODUCTION: Cerebral malaria is a common cause of neurological sequelae and death in childhood. Information on persistent neurological sequelae post hospital discharge and their predisposing factors are scarce. METHODS: This is a prospective study describing persisting neurological impairments post discharge among children treated for cerebral malaria. In addition the study was designed to investigate the frequency of persistent neurologic deficits and the risk factors for their persistence in these patients...
2013: Pan African Medical Journal
J Bockenmeyer, E Chamboredon, F Missud, M Benkerrou, L Holvoët, G Ithier, B Lescoeur, K Yakouben, M Ouachée-Chardin, P-S Rohrlich, M Duval, A Baruchel, J-H Dalle
RATIONALE: Allogeneic hematopoietic stem-cell transplantation (HSCT) is the only curative treatment for sickle cell disease (SCD). Cerebral vasculopathy was the principal indication for transplantation. These children could present impaired neuropsychological development related to different causes, hence the value of exploring their intellectual capacities before and after transplantation. MATERIAL AND METHODS: Prospective longitudinal study from 1992 to 2006 in all transplanted SCD patients...
July 2013: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Ling-Jen Wang, Shu-Chi Mu, Cheng-Hui Lin, Ming-I Lin, Tseng-Chen Sung
BACKGROUND: Community-acquired pneumonia (CAP) remains a significant cause of childhood morbidity worldwide. We analyzed the etiologies and the clinical characteristics of children who died from CAP. This study aimed at early identification of the poor prognostic factors in order to improve the efficiency of pneumonia management and prevent deaths. METHODS: A retrospective chart review was performed for children younger than 18 years admitted to Shin Kong Wu Ho-Su Memorial Hospital between September 1992 and August 2010 with a diagnosis of pneumonia on admission...
February 2013: Pediatrics and Neonatology
Jeannine Baumgartner, Cornelius M Smuts, Linda Malan, Jane Kvalsvig, Martha E van Stuijvenberg, Richard F Hurrell, Michael B Zimmermann
BACKGROUND: Little is known about the combined effects of iron and n-3 (omega-3) fatty acid (FA) supplementation on cognitive performance. The provision of either DHA/EPA or iron alone in rats with combined iron and n-3 FA deficiency has been reported to exacerbate cognitive deficits associated with deficiency. OBJECTIVE: We investigated the effects of iron and DHA/EPA supplementation, alone and in combination, in children with poor iron and n-3 FA status. DESIGN: In a 2-by-2 factorial trial, children with iron deficiency (ID) (n = 321; aged 6-11 y) were allocated to receive 1) iron (50 mg) plus DHA/EPA (420/80 mg), 2) iron plus placebo, 3) placebo plus a mixture of DHA and EPA (DHA/EPA), or 4) placebo plus placebo as oral supplements (4/wk) for 8...
December 2012: American Journal of Clinical Nutrition
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