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https://www.readbyqxmd.com/read/29036563/loss-of-cd15-expression-in-clear-cell-renal-cell-carcinoma-is-correlated-with-worse-prognosis-in-chinese-patients
#1
Chen-Yan Wu, Jian-Ping Huo, Xin-Ke Zhang, Yi-Jun Zhang, Wan-Ming Hu, Ping Yang, Jia-Bin Lu, Zhi-Ling Zhang, Yun Cao
Purpose: To explore the role of CD15 expression in the prognosis of clear cell renal cell carcinoma (ccRCC) in Chinese patients. Methods: The study included 301 patients who had undergone surgery for localized ccRCC. All paraffin-embedded tumor sections were collected to make a set of tissue microarrays. CD15 expression was assessed by immunohistochemistry. The relationship between CD15 expression and survival parameters, clinicopathology features was assessed. Kaplan-Meier and Cox proportional hazards model were utilized to determine the correlation between CD15 expression and overall survival (OS)...
September 21, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29034514/measurement-of-murine-single-kidney-glomerular-filtration-rate-using-dynamic-contrast-enhanced-mri
#2
Kai Jiang, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
PURPOSE: To develop and validate a method for measuring murine single-kidney glomerular filtration rate (GFR) using dynamic contrast-enhanced MRI (DCE-MRI). METHODS: This prospective study was approved by the Institutional Animal Care and Use Committee. A fast longitudinal relaxation time (T1 ) measurement method was implemented to capture gadolinium dynamics (1 s/scan), and a modified two-compartment model was developed to quantify GFR as well as renal perfusion using 16...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29034078/recent-advances-in-cancer-surgery-in-older-patients
#3
REVIEW
Siri Rostoft, Riccardo A Audisio
Age is the most important risk factor for the occurrence of cancer, and a declining mortality from heart disease and other non-cancer causes leaves an older population that is at high risk of developing cancer. Choosing the optimal treatment for older cancer patients may be a challenge. Firstly, older age and associated factors such as comorbidities, functional limitations, and cognitive impairment are risk factors for adverse effects of cancer treatment. Secondly, older patients are often excluded from clinical trials, and current clinical guidelines rarely address how to manage cancer in patients who have comorbidities or functional limitations...
2017: F1000Research
https://www.readbyqxmd.com/read/29034031/coronary-artery-bypass-surgery-in-end-stage-renal-disease-patients
#4
REVIEW
Daijiro Hori, Atsushi Yamaguchi, Hideo Adachi
The number of patients requiring hemodialysis is continuously increasing around the world. Hemodialysis affects patient quality of life and it is also associated with a higher risk for cardiovascular events. In addition to traditional risk factors for cardiovascular events such as hypertension, hyperlipidemia, and diabetes, hemodialysis is associated with hyperphosphatemia, chronic inflammation, vascular calcification, and anemia which accelerate atherosclerosis, vascular stiffness, and cardiac ischemia. Treatment strategy for coronary revascularization in this progressive disease remains controversial...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032581/utilization-and-quality-outcomes-of-ct1a-ct1b-and-ct2a-partial-nephrectomy-analysis-of-the-national-cancer-database
#5
Katherine Fero, Zachary A Hamilton, Ahmet Bindayi, James D Murphy, Ithaar H Derweesh
OBJECTIVE: To describe utilization and compare quality outcomes of partial nephrectomy (PN) for cT1a, cT1b and cT2a renal mass using a large national database. METHODS: Retrospective analysis of patients from the US National Cancer Database who underwent PN for cT1a/cT1b/T2a renal cell carcinoma between 2004-2013. We examined utilization of PN over time and quality indicators [positive surgical margin (PSM) and 30-day postoperative readmission rates (30Day-Readmit)]...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032332/long-term-treatment-with-chaethomellic-acid-a-reduces-glomerulosclerosis-and-arteriolosclerosis-in-a-rat-model-of-chronic-kidney-disease
#6
António Nogueira, Helena Vala, Carmen Vasconcelos-Nóbrega, Ana Isabel Faustino-Rocha, Carlos André Pires, Aura Colaço, Paula Alexandra Oliveira, Maria João Pires
The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5/6 renal mass reduction (RMR). One week after surgery, rats were placed in four experimental groups: SO:SO rats without treatment (n=13); SO+CAA: SO rats treated with CAA (n=13); RMR:RMR rats without treatment (n=14); and RMR+CAA:RMR rats treated with CAA (n=13)...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29032237/hospital-charges-and-length-of-stay-following-radical-cystectomy-in-the-eras-era
#7
Alice Semerjian, Niv Milbar, Max Kates, Michael A Gorin, Hiten D Patel, Heather J Chalfin, Steven M Frank, Christopher L Wu, William W Yang, Deb Hobson, Lindsay Robertson, Elizabeth Wick, Mark P Schoenberg, Phillip M Pierorazio, Michael H Johnson, C J Stimson, Trinity J Bivalacqua
OBJECTIVE: To report our center's experience with Enhanced Recovery after Surgery (ERAS) pathway for radical cystectomy (RC), specifically evaluating complications, LOS, 30- and 90-day readmissions, and hospital charges. Pathways of this type have been shown to decrease length of stay (LOS) and post-operative ileus. However, concerns persist that ERAS is costly and increases readmissions. To date, limited studies have evaluated these concerns. MATERIALS AND METHODS: Our ERAS protocol was implemented for RC in December 2015...
October 12, 2017: Urology
https://www.readbyqxmd.com/read/29032236/renal-trauma-in-pediatrics-a-current-review
#8
REVIEW
Maria Fernandez-Ibieta
Children are at increased risk of renal injuries from blunt trauma. Four phase CT with intravenous contrast (non contrast, arterial, nephrographic, and pyelographic phases) is the choice for initial imaging, although ultrasonography might be used in the children with minimal symptoms. The American Association for the Surgery of Trauma developed the known system for renal injury grading, which was modified in 2011. The management of pediatric renal injuries has largely shifted towards conservative means. But as long as the child remains hemodynamically unstable, renal exploration might be necessary...
October 12, 2017: Urology
https://www.readbyqxmd.com/read/29032235/variation-in-radiologic-and-urologic-computed-tomography-interpretation-of-urinary-tract-stone-burden-results-from-resku
#9
David T Tzou, Dylan Isaacson, Manint Usawachintachit, Zhen J Wang, Kazumi Taguchi, Nancy K Hills, Ryan S Hsi, Benjamin A Sherer, Shalonda Reliford-Titus, Brian Duty, Jonathan Harper, Mathew Sorensen, Roger L Sur, Marshall L Stoller, Thomas Chi
OBJECTIVE: To compare the measured stone burden recorded between urologists and radiologists, and examine how these differences could potentially impact stone management. As current urologic stone surgery guideline recommendations are based on stone size, accurate stone measurements are crucial to direct appropriate treatment. This study investigated the discrepant interpretation that often exists between urologic surgeons and radiologists' estimation of patient urinary stone burden. MATERIALS AND METHODS: From November 2015 through August 2016, new patients prospectively enrolled into the Registry for Stones of the Kidney and Ureter (ReSKU™) were included if they had computed tomography images available and an accompanying official radiologic report at the time of their urologist provider visit...
October 12, 2017: Urology
https://www.readbyqxmd.com/read/29031030/ectopic-bone-as-a-nidus-for-calcium-oxalate-urocystolithiasis-in-a-cat
#10
J P Lulich, H S Prasad, M Manno, B Bagley
A 7-year-old female spayed domestic shorthair cat was referred to the urology service for nonsurgical urocystolith removal. A urolith was attached to the urothelium by ectopic bone. Interventional removal without surgery was successful. Follow-up evaluation 3 years after urolith removal revealed recurrent uroliths, bladder wall mineralization, and marked renal mineralization. This case illustrates the metaplastic potential of the urothelium and that ectopic bone should be included among the pathological factors that promote lithogenesis...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29030366/role-of-transoesophageal-echocardiography-in-renal-cell-carcinoma-a-brief-review
#11
Chitra Rajeswari Thangaswamy, Ramanitharan Manikandan, Sai Chandran Bathala Vedagiri
Transoesophageal echocardiography (TOE) is regularly used in cardiac and also increasingly in non-cardiac surgeries. It has a leading role in the perioperative management of renal cell carcinoma with tumour extension into inferior vena cava. We report two cases in which TOE was of immense help for patient management. This report highlights the two cases where intraoperative TOE was of immense help to establish diagnosis, to modify surgical plan, to guide the surgeon during clamp placement, to monitor cardiac function, to rule out tumour embolism and to confirm the complete removal of tumour thrombus...
October 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29030159/obstructive-m%C3%A3-llerian-anomalies-in-menstruating-adolescent-girls-a-report-of-22-cases
#12
Karina Kapczuk, Zbigniew Friebe, Kinga Iwaniec, Witold Kędzia
STUDY OBJECTIVE: To assess the clinical course of obstructive Müllerian anomalies found in girls after menarche DESIGN: A retrospective case series of adolescents who between 2009 and 2016 were treated for vaginal or uterine obstructive malformations diagnosed after menarche SETTING: Division of Gynecology, Poznań University of Medical Sciences, Poznań, Poland PARTICIPANTS: Twenty-two patients who, at the age of 11.4-18.2 (median 13.1) years, between 2 and 74 (median 7.5) months after menarche, underwent surgical repair of obstructive genital anomaly MAIN OUTCOME MEASURES: Müllerian defect type, presentation, radiologic findings, pre- and postoperative course RESULTS: Eighteen patients (81...
October 10, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29030073/comparative-analysis-of-surgery-thermal-ablation-and-active-surveillance-for-renal-oncocytic-neoplasms
#13
Brady L Miller, Lori Mankowski Gettle, Jason R Van Roo, Timothy J Ziemlewicz, Sara L Best, Shane A Wells, Meghan G Lubner, J Louis Hinshaw, Fred T Lee, Stephen Y Nakada, Wei Huang, E Jason Abel
OBJECTIVE: To compare oncologic and procedural outcomes for renal oncocytic tumors treated with surgery, thermal ablation or active surveillance. METHODS AND MATERIALS: Clinical and pathologic data were collected for consecutive patients with a histological diagnosis of oncocytoma, oncocytic neoplasm or chromophobe renal cell cancers (chRCC) from 2003-2016. Independent pathology and radiology review was performed for this study. RESULTS: Of 171 patients, tumor histology included oncocytoma (n=122), chRCC (n=47) and oncocytic neoplasm not otherwise specified (n=2)...
October 10, 2017: Urology
https://www.readbyqxmd.com/read/29028633/acute-kidney-injury-in-congenital-heart-disease
#14
Katja M Gist, David M Kwiatkowski, David S Cooper
PURPOSE OF REVIEW: Acute kidney injury (AKI) is associated with significant morbidity and mortality in patients with congenital heart disease undergoing cardiac surgery or in pediatric patients with congestive heart failure. RECENT FINDINGS: This review describes the definition and various manifestations of AKI, the impact of biomarkers on the diagnosis of AKI, the importance of fluid overload as a consequence of AKI and its long-term impact. SUMMARY: There are novel biomarkers for AKI detection that should facilitate early recognition and intervention to prevent or attenuate the effects of AKI and fluid overload...
October 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29027269/partial-nephrectomy-for-small-children-robot-assisted-versus-open-surgery
#15
Quentin Ballouhey, Aurélien Binet, Pauline Clermidi, Karim Braik, Thierry Villemagne, Jérôme Cros, Hubert Lardy, Laurent Fourcade
OBJECTIVES: To compare the outcomes of robot-assisted heminephrectomy for duplex kidney in children with those of open heminephrectomy. METHODS: The present retrospective multicentric analysis reviewed the records of robot-assisted versus open heminephrectomy carried out for duplex kidney in children from 2007 to 2014. Demographic data, weight, surgical time, hospital stay, complications and outcome were recorded. Follow up was based on a clinical review, renal sonography and dimercaptosuccinic acid renal scintigraphy...
October 13, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29027072/outcomes-of-acute-kidney-injury-in-a-nephrology-ward
#16
Ana R Fernandes, Márcio S R Viegas, Elsa Q Soares, Sofia S Coelho, Patricia Valério, José C Barreto, José M Vinhas
Acute kidney injury (AKI) is a global problem which predicts immediate and long-term adverse outcomes. We evaluated the AKI progression to end-stage renal disease, as well as the mortality associated with AKI and the in-hospital readmission rate because of a cardiovascular event in AKI patients admitted in a nephrology ward. A 5-year retrospective study was set in a nephrology department, with a follow-up period of up to 8 years. In a total of 191 patients, mean age was 73.83 ± 12.49 years, and 137 (71...
October 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29026845/osteonecrosis-of-the-jaws-in-patient-received-bisphosphonates-and-sunitinib-separately-a-case-report
#17
Farzaneh Ashrafi, Ali Derakhshandeh, Bijan Movahedian, Azadeh Moghaddas
Recently published reports have suggested that antiangiogenic drugs such as sunitinib could potentiate the osteonecrosis of the jaw (ONJ) induced by bisphosphonates (BPs) and even induce this adverse effect per se. We reported a case of ONJ with renal cell carcinoma under sunitinib medication and history of BPs therapy. A 53-year-old man was referred to the oral surgery clinic complaining of painful exposed oral lesion and bone extraction from right lower jaw in the mouth. He underwent nephrectomy followed by 5 months treatment with cycles of 50 mg sunitinib (Sutent(®)) once a day for 4 weeks followed by 2 weeks drug free before lesion exposure in October 2016...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29025611/carbon-fiber-reinforced-intramedullary-nailing-in-musculoskeletal-tumor-surgery-a-national-multicentric-experience-of-the-italian-orthopaedic-society-siot-bone-metastasis-study-group
#18
Andrea Piccioli, Raimondo Piana, Michele Lisanti, Alberto Di Martino, Barbara Rossi, Francesco Camnasio, Marco Gatti, Pietro Maniscalco, Franco Gherlinzoni, Maria Silvia Spinelli, Davide Maria Donati, Roberto Biagini, Rodolfo Capanna, Vincenzo Denaro
INTRODUCTION: Carbon fiber reinforced (CFR) implants have been proposed for the treatment of fractures or impending fractures of the long bones in the oncology patient. Aim of this study is to present the largest cohort of oncology patients operated by CFR nailing by the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group. METHODS: 53 adult oncology patients were operated on with a CFR-PEEK nail. All the data from adjuvants therapies were collected. Bone callus formation, response to radiotherapy, relapse or progression of the osteolysis were recorded...
October 2017: Injury
https://www.readbyqxmd.com/read/29024736/a-survey-regarding-preference-in-management-of-bilateral-stone-disease-and-comparison-of-clavien-complication-rate-in-bilateral-versus-unilateral-percutaneous-nephrolithotomy
#19
Marcelino E Rivera, Naeem Bhojani, Kevin Heinsimer, Marawan M El Tayeb, Jessica E Paonessa, Amy E Krambeck, James E Lingeman
PURPOSE: To discuss complications of simultaneous bilateral percutaneous nephrolithotomy (SB-PCNL) when compared to unilateral percutaneous nephrolithotomy (U-PCNL) and survey surgeon preference in bilateral stone disease management. MATERIALS AND METHODS: A database of all participating PCNL patients who received treatment at Indiana University Health Methodist Hospital within a 10-year period from 2006 to 2015 by a single surgeon (JL) was utilized. Perioperative data as well as complications, as defined according the Clavien grading system, were recorded...
October 9, 2017: Urology
https://www.readbyqxmd.com/read/29021656/a-randomized-controlled-study-comparing-the-standard-tubeless-and-totally-tubeless-percutaneous-nephrolithotomy-procedures-for-renal-stones-from-a-tertiary-care-hospital
#20
Suresh Bhat, Jithin Lal, Fredrick Paul
INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is an effective treatment for renal stones. Due to the significant pain and morbidity after standard PCNL because of nephrostomy tubes, various modifications of PCNL are being performed. We report a randomized trial comparing these modalities. MATERIALS AND METHODS: A total of 75 patients were randomized into three groups of 25 each: standard PCNL with nephrostomy tubes (Group 1), tubeless PCNL with ureteric stent and no nephrostomy (Group 2), and totally tubeless PCNL without ureteric catheter or nephrostomy (Group 3)...
October 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
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