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https://www.readbyqxmd.com/read/28538099/iodide-selective-synthetic-ion-channels-based-on-shape-persistent-organic-cages
#1
Bahiru Punja Benke, Pulakesh Aich, Younghoon Kim, Kyung Lock Kim, Md Rumum Rohman, Soonsang Hong, In-Chul Hwang, Eun Hui Lee, Joon Ho Roh, Kimoon Kim
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems...
May 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28538085/circulating-heparan-sulfate-fragments-attenuate-histone-induced-lung-injury-independently-of-histone-binding
#2
Yanlin Zhang, Sarah M Haeger, Yimu Yang, Kyrie L Dailey, Joshay A Ford, Eric P Schmidt
Extracellular histones are cationic damage-associated molecular pattern molecules capable of directly inducing cellular injury via charge-mediated interactions with plasma membranes. Accordingly, histones released into the plasma during critical illness are known to contribute to the onset and propagation of lung injury. Vascular injury (with consequent degradation of the endothelial glycocalyx) simultaneously releases anionic heparan sulfate fragments (hexa- to octasaccharides in size) into the plasma. It is unknown whether this endogenous release of heparan sulfate fragments modulates charge-dependent histone cytotoxicity, or if exogenous heparan sulfate fragments could therapeutically attenuate histone-induced lung injury...
May 23, 2017: Shock
https://www.readbyqxmd.com/read/28537736/probing-the-cleaning-of-polymeric-coatings-by-nanostructured-fluids-a-qcm-d-study
#3
Martina Raudino, Nicoletta Giamblanco, Costanza Montis, Debora Berti, Giovanni Marletta, Piero Baglioni
Complex fluids composed of water, an organic solvent and a surfactant have been recently employed as cleaning systems to remove hydrophobic materials, such as polymeric coatings, from solid surfaces. The simultaneous presence of surfactants and an organic solvent with good affinity for the polymer was proven necessary for the polymer's removal, but the comprehension of the cleaning mechanism is poorly understood. In this article we investigated the mechanism of removal, highlighting the specific role of each component in the interaction with the polymer film...
May 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28537724/palladium-catalyzed-enantioselective-arylation-of-aryl-sulfenate-anions-a-combined-experimental-and-computational-study
#4
Tiezheng Jia, Mengnan Zhang, Samuel P McCollom, Ana Bellomo, Sonia Montel, Jianyou Mao, Spencer D Dreher, Christopher J Welch, Erik L Regalado, R Thomas Williamson, Brian C Manor, Neil C Tomson, Patrick J Walsh
A novel approach to produce chiral diaryl sulfoxides from aryl benzyl sulfoxides and aryl bromides via an enantioselective arylation of aryl sulfenate anions is reported. A (JosiPhos)Pd-based catalyst successfully promotes the asymmetric arylation reaction with good functional group compatibility. A wide range of enantioenriched diaryl, aryl heteroaryl, and even diheteroaryl sulfoxides were generated. Many of the sulfoxides prepared herein would be difficult to prepare via classic enantioselective oxidation of sulfides, including Ph(Ph-d5)SO (90% ee, 95% yield)...
May 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28535480/ozonation-of-the-oxybenzone-octinoxate-and-octocrylene-uv-filters-reaction-kinetics-absorbance-characteristics-and-transformation-products
#5
Zachary R Hopkins, Sebastian Snowberger, Lee Blaney
UV-filters (UVFs) are active ingredients in personal care products that protect skin from exposure to UV light. Environmentally-relevant concentrations of UVFs have recently been linked to toxicity in aquatic organisms, necessitating research into improved UVF removal in water/wastewater treatment. Here, we investigated ozonation of the three most commonly employed UVFs: octinoxate (OMC), octocrylene (OC), and oxybenzone (OXY). Specific second-order rate constants for UVF reaction with ozone were identified as follows: OMC, 5...
May 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28535055/ionic-liquid-anion-controlled-nanoscale-gold-morphology-grown-at-a-liquid-interface
#6
Nakara Bhawawet, Jeremy B Essner, Durgesh Vinod Wagle, Gary A Baker
Two different ionic liquids comprising the tetrabutylphosphonium cation ([P4444]) paired with the strongly-coordinating anions 6-aminocaproate ([6-AC]) or taurinate ([tau]) were prepared and employed in an aqueous/organic liquid bilayer system to generate nanoscale gold by Au(OH)4- photoreduction. Generally, as the concentration of ionic liquid in the organic phase was increased, the resulting quasi-spherical gold nanoparticles reduced in size and presented less aggregation, leading to marked increases in the catalytic efficiency for 4-nitrophenol reduction using borohydride...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28535051/structural-properties-of-nonionic-monorhamnolipid-aggregates-in-water-studied-by-classical-molecular-dynamics-simulations
#7
Elango Munusamy, Charles M Luft, Jeanne E Pemberton, Steven D Schwartz
Molecular dynamics simulations were carried out to investigate the structure and stabilizing factors of aggregates of the nonionic form of the most common congener of monorhamnolipids, α-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydecanoate (Rha- C10-C10), in water. Aggregates of size ranging from 5 monomers to 810 monomers were observed in the simulation forming spherical and ellipsoidal structures, a torus like structure and a unilamellar vesicle. The effects of hydrophobic chain conformation and alignment in the aggregate, role of H-bonds between monomer...
May 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28534913/theoretical-investigation-of-energy-gap-bowing-in-cdsxse1-x-alloy-quantum-dots
#8
Laxman Tatikondewar, Anjali Kshirsagar
To investigate energy gap bowing in homogeneously alloyed CdSxSe1-x quantum dots (QDs) and to understand whether it is different from bulk, we perform density functional theory based electronic structure calculations for spherical QDs of different compositions x (0 ≤ x ≤ 1) and of varying sizes (2.2 to 4.6 nm). We find the bowing constant to be slightly higher than in bulk for different sizes of quantum dots. The change in the highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap of QDs mainly arises due to the change in the LUMO energies...
May 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28534622/solute-partitioning-in-micelles-combining-molecular-dynamics-simulations-cosmomic-and-experiments
#9
Denitsa Yordanova, Eric Ritter, Thomas Gerlach, Jan-Hendrik Jensen, Irina Smirnova, Sven Jakobtorweihen
The partition equilibria of solutes between micelles and an aqueous phase is a key factor in many applications. Depending on the task, many micelle-solute combinations are possible. Therefore, theoretical methods to predict the partition behavior in micellar systems are needed. Here, two predictive methods are evaluated and compared. First, it is shown how molecular dynamics simulations (MD) with the umbrella sampling method can be used to calculate free energy profiles in micellar systems. The second applied method is an extension of the COSMO-RS theory to anisotropic systems termed COSMOmic...
May 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28534579/deprotonated-meso-hydroxyporphyrin-as-a-stable-%C3%AF-electronic-anion-the-building-unit-of-an-ion-pairing-assembly
#10
Yoshifumi Sasano, Nobuhiro Yasuda, Hiromitsu Maeda
The Ni(II) complex of 5-hydroxy-10,15,20-tris(pentafluorophenyl)-porphyrin was synthesized as the precursor of a negatively charged π-electronic system. Deprotonation, which was examined through UV/vis and (1)H NMR spectra, provided an anionic species as the building unit of an ion-pairing assembly in combination with an aliphatic cation.
May 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28534572/sensing-of-fluoride-ions-in-aqueous-media-using-a-luminescent-coordination-polymer-and-liposome-composite
#11
Masayuki Honjo, Tomomi Koshiyama, Yumi Fukunaga, Yasuhiro Tsuji, Motoki Tanaka, Masaaki Ohba
The synthesis of a luminescent coordination polymer (Tb-BTC) within the confined environment of a liposome allowed for the anisotropic growth of nanosized Tb-BTC crystals. Consequently, the resulting composite Tb-BTC@Lipo exhibited a higher fluorescence sensitivity to fluoride anions in aqueous media compared to the independent Tb-BTC in bulk.
May 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28534121/organic-anion-transporters-oat1-and-oat3-are-crucial-biopterin-transporters-involved-in-bodily-distribution-of-tetrahydrobiopterin-and-exclusion-of-its-excess
#12
Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa
Tetrahydrobiopterin (BH4) is a common coenzyme of phenylalanine-, tyrosine-, and tryptophan hydroxylases, alkylglycerol monooxygenase, and NO synthases (NOS). Synthetic BH4 is used medicinally for BH4-responsive phenylketonuria and inherited BH4 deficiency. BH4 supplementation has also drawn attention as a therapy for various NOS-related cardio-vascular diseases, but its use has met with limited success in decreasing BH2, the oxidized form of BH4. An increase in the BH2/BH4 ratio leads to NOS dysfunction. Previous studies revealed that BH4 supplementation caused a rapid urinary loss of BH4 accompanied by an increase in the blood BH2/BH4 ratio and an involvement of probenecid-sensitive but unknown transporters was strongly suggested in these processes...
May 22, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28533577/the-interaction-between-trolox-and-4-4-diisothiocyanatostilbene-2-2-disulfonic-acid-on-hypoxic-pulmonary-vasoconstriction-in-the-isolated-rabbit-lung
#13
Somayh Mansoori, Seyed Mostafa Shid Moosavi, Farzaneh Ketabchi
BACKGROUND: The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion exchanger in acute HPV. METHODS: The present study was performed in the isolated rabbit lung...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28532671/ochratoxin-a-transport-by-the-human-breast-cancer-resistance-protein-bcrp-multidrug-resistance-protein-2-mrp2-and-organic-anion-transporting-polypeptides-1a2-1b1-and-2b1
#14
Xiaozhe Qi, Els Wagenaar, Wentao Xu, Kunlun Huang, Alfred H Schinkel
Ochratoxin A (OTA) is a fungal secondary metabolite that can contaminate various foods. OTA has several toxic effects like nephrotoxicity, hepatotoxicity, and neurotoxicity in different animal species, but its mechanisms of toxicity are still unclear. How OTA accumulates in kidney, liver, and brain is as yet unknown, but transmembrane transport proteins are likely involved. We studied transport of OTA in vitro, using polarized MDCKII cells transduced with cDNAs of the efflux transporters mouse (m)Bcrp, human (h)BCRP, mMrp2, or hMRP2, and HEK293 cells overexpressing cDNAs of the human uptake transporters OATP1A2, OATP1B1, OATP1B3, or OATP2B1 at pH7...
May 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28532626/single-nucleotide-polymorphisms-of-abcc2-modulate-renal-secretion-of-endogenous-organic-anions
#15
Kienana Muhrez, Bérenger Largeau, Patrick Emond, Montigny Frédéric, Jean-Michel Halimi, Patrick Trouillas, Chantal Barin-LE Guellec
The ATP-binding cassette family transporter MRP2 (multidrug resistance-associated protein 2), encoded by the ABCC2 gene, is involved in the renal excretion of numerous xenobiotics and it is likely that it also transports many endogenous molecules arising from not only normal essential metabolic processes but also from environmental toxins or food intake. We used a targeted gas chromatography-mass spectrometry metabolomics analysis to study whether endogenous organic anions are differentially excreted in urines of healthy volunteers according to their genotype for three functional single nucleotide polymorphisms (SNPs) in ABCC2...
May 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28532211/rotenone-induces-nephrotoxicity-in-rats-oxidative-damage-and-apoptosis
#16
Xiao-Wen Jiang, Lu Qiao, Xin-Xin Feng, Lin Liu, Qing-Wei Wei, Xue-Wei Wang, Wen-Hui Yu
Previous studies have examined rotenone toxicity on the human central nervous system, especially in the pathogenesis of Parkinson's disease, but few have investigated the effects of rotenone on the kidney. Here, rotenone-induced nephrotoxicity was evaluated by determining morphological, biochemical, oxidative stress-related, and apoptotic factor alterations in rat renal tissue. Morphological and biochemical analyses showed that rotenone administration to rats damaged renal tissue. Western blot results revealed that rotenone induced oxidative damage, causing overproduction of glutathione, malonaldehyde, and reactive oxygen species (ROS), and inhibiting superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity...
May 22, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28532126/poly-%C3%AE-glutamic-acid-coated-lipoplexes-loaded-with-doxorubicin-for-enhancing-the-antitumor-activity-against-liver-tumors
#17
Na Qi, Bo Tang, Guang Liu, Xingsi Liang
The study was to develop poly-γ-glutamic acid (γ-PGA)-coated Doxorubicin (Dox) lipoplexes that enhance the antitumor activity against liver tumors. γ-PGA-coated lipoplexes were performed by electrostatistically attracting to the surface of cationic charge liposomes with anionic γ-PGA. With the increasing of γ-PGA concentration, the particle size of γ-PGA-coated Dox lipoplexes slightly increased, the zeta potential from positive shifted to negative, and the entrapment efficiency (EE) were no significant change...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28532083/effects-for-rapid-conversion-from-abalone-shell-to-hydroxyapaptite-nanosheets-by-ionic-surfactants
#18
Shengnan Zhong, Zhenliang Wen, Jingdi Chen, Qian Li, Xuetao Shi, Shinnjyh Ding, Qiqing Zhang
Hydroxyapatite (HAP) has been widely used for repairing or substituting human hard tissues. In this paper, two typical ionic surfactants, cation hexadecyltrimethylammonium bromide (CTAB) and anion sodium dodecyl sulfate (SDS), were used for rapid conversion of HAP from abalone shell. From field emission scanning electron microscopy (FESEM), the prepared HAP is flake-like structure. From X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and thermal analysis, these samples contain a small amount of calcium carbonate whose content gradually increases by increasing the surfactants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532075/can-pei-microgels-become-biocompatible-upon-betainization
#19
Nurettin Sahiner, Sahin Demirci
Polyethylene imine (PEI) microgels prepared via micro emulsion polymerization technique were treated with 1,3-propane sultone to obtained betainized PEI (b-PEI) microgels. The betainization reaction generated zwitterions on PEI microgel that are positive charges from quarternized amine groups of PEI, and the newly formed negative charges from SO3(-) groups from the modifying agent, 1,3-propane sultone offered interesting properties. The smaller size of b-PEI microgels that are obtained by simple filtration were increased with betainization from 512±14 to 1114±86nm...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532025/new-tetrahedral-zinc-halide-schiff-base-complexes-synthesis-crystal-structure-theoretical-3d-hirshfeld-surface-analyses-antimicrobial-and-thermal-studies
#20
L Taghizadeh, M Montazerozohori, A Masoudiasl, S Joohari, J M White
A new bidentate Schiff base ligand named as N,N'-bis((E)-3-phenylallylidene)butane-1,4-diamine (L) and three its zinc halide complexes were synthesized and characterized by FT-IR, (1)H NMR, (13)C NMR and UV-Vis spectroscopy. The crystal structure of zinc bromide and iodide complexes were characterized using single crystal X-ray diffraction. The two structures are isomorphous, crystallizing in the monoclinic crystal system with space group C2/c with closely similar unit cell dimensions. In these complexes, the Zn(II) ion is in the center of a distorted tetrahedral environment completed by two iminic nitrogen atoms of Schiff base ligand and two halide anions...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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