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https://www.readbyqxmd.com/read/29353278/stereoselective-inhibition-of-renal-basolateral-human-organic-anion-transporter-3-by-lansoprazole-enantiomers
#1
Yugo Hamada, Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda
Lansoprazole, a proton pump inhibitor, potently inhibits human organic anion transporter, hOAT3 (SLC22A8). Lansoprazole has an asymmetric atom in its structure and is clinically administered as a racemic mixture of (R)-and (S)-enantiomers. However, little is known about the stereoselective inhibitory potencies of lansoprazole against hOAT3 and its homolog, hOAT1. In the present study, the stereoselective inhibitory effect of lansoprazole was evaluated using hOAT1-and hOAT3-expressing cultured cells. hOAT1 and hOAT3 transported [14C]p-aminohippurate and [3H]estrone-3-sulfate (ES) with Michaelis-Menten constants of 29...
January 19, 2018: Pharmacology
https://www.readbyqxmd.com/read/29353116/scale-inhibition-and-flocculation-dual-functionality-of-poly-acrylic-acid-grafted-starch
#2
Qing Du, Yawen Wang, Aimin Li, Hu Yang
Natural-polymer based water treatment agents have recently received much more attention due to their environmental friendliness, widespread availability, and prominent structural features. Starch-graft-poly(acrylic acid) (St-g-PAA) is a simple natural-polymer based material that can be obtained easily by a one-step graft copolymerization. When used as a water treatment agent, St-g-PAA exhibits both effective scale-inhibition performance and high turbidity removal efficiency. The scale-inhibition efficiency of St-g-PAA against calcium carbonate (CaCO3) is approximately 94% at the optimal dose in a static test of approximately 40 mg/L...
January 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29353085/reactions-of-a-tetranuclear-pt-thiosemicarbazone-complex-with-model-proteins
#3
Tiziano Marzo, Francisco Navas, Damiano Cirri, Antonello Merlino, Giarita Ferraro, Luigi Messori, Adoracion G Quiroga
The tetranuclear Pt complex (PtL)4 (where L2- is the anion derived from para-isopropyl thiosemicarbazone) was first described in A.G. Quiroga et al., J. Med. Chem. 41, 1998, 1399-1408. (PtL)4 manifests antiproliferative properties toward various cancer cell lines being a promising anticancer drug candidate. Yet, details of its reactivity with biomolecules have not been elucidated. To this end, we investigated the reactions of (PtL)4 with a few model proteins, i.e. bovine pancreatic ribonuclease (RNase A), cytochrome c (Cyt c) and hen egg white lysozyme (Lysozyme), through electrospray ionization mass spectrometry and other biophysical methods...
January 10, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29352929/structural-characterization-antioxidant-and-hepatoprotective-activities-of-polysaccharides-from-sophorae-tonkinensis-radix
#4
Liangliang Cai, Shanshan Zou, Dengpan Liang, Libiao Luan
In current study we present two polysaccharides, STRP1 and STRP2, purified from Sophorae tonkinensis Radix via column chromatography. Structural analyses indicated that STRP1 and STRP2 were consisted of mannose, rhamnose, glucuronic acid, glucose, galactose and arabinose in a similar molar ratio with main backbones of (1 → 3)-linked-α-d-Gal and (1 → 4)-linked-α-d-Glc, while average molecular weights were 1.30 × 104 and 1.98 × 105 Da, respectively. We observed a strong chelating ability on ferrous ions; substantial radical scavenging activities on DPPH, hydroxyl and superoxide anion radicals in vitro; and significant attenuation on acetaminophen-induced hepatic oxidative damage in mice for STRP1 and STRP2...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352927/self-assembly-and-rheological-behaviors-of-intermacromolecular-complexes-consisting-of-oppositely-charged-fluorinated-guar-gums
#5
Chen Wang, Liewei Qiu, Tao Wang
We synthesized fluorinated cationic/anionic guar gums (FCGG and FAGG) and characterized these species using Fourier transform infrared spectroscopy and 1H nuclear magnetic resonance spectroscopy. The degree of fluorine substitution of FCGG (0.26%) and FAGG (0.21%) was calculated by elemental analysis. In addition, we explored the self-assembly and rheological behaviors of FCGG-FAGG complexes by viscometry, scanning electron microscopy, light scattering, fluorescence spectroscopy, and rheometry. The maximum viscosity and molecular weights were observed with a FAGG:FCGG mass ratio of 7...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352895/sequencing-the-oligosaccharide-pool-in-the-low-molecular-weight-heparin-dalteparin-with-offline-hplc-and-esi-ms-ms
#6
Zhangjie Wang, Tianji Zhang, Shaoshuai Xie, Xinyue Liu, Hongmei Li, Robert J Linhardt, Lianli Chi
Low molecular weight heparins (LMWHs) are widely used anticoagulant drugs. The composition and sequence of LMWH oligosaccharides determine their safety and efficacy. The short oligosaccharide pool in LMWHs undergoes more depolymerization reactions than the longer chains and is the most sensitive indicator of the manufacturing process. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) has been demonstrated as a powerful tool to sequence synthetic heparin oligosaccharide but never been applied to analyze complicated mixture like LMWHs...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352887/the-development-of-an-alginate-polycaprolactone-composite-scaffold-for-in-situ-transfection-application
#7
Wei-Wen Hu, Yun-Chung Wu, Zhe-Chen Hu
Alginate and polycaprolactone (PCL) were coelectrospun using a dual-jet system to prepare composite nanofibers in defined ratios, and hence both chemical properties and hydrophobicity of scaffolds can be manipulated. These nanofibers were applied in gene immobilization: positively charged polyethyleneimine (PEI)/DNA polyplexes were adsorbed onto anionic alginate fibers, and the higher ratios of alginate resulted in the more immobilized nonviral vectors. Through the incorporation of PCL, biocompatibility of scaffolds was highly improved...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352872/preparation-and-testing-of-a-tetra-amine-copper-ii-chitosan-bead-system-for-enhanced-phosphate-remediation
#8
Ilango Aswin Kumar, Natrayasamy Viswanathan
A tetra-amine copper(II) chitosan bead system (TAC@CS composite beads) was developed by grafting tetra-amine copper(II) (TAC) with chitosan (CS) and utilized for phosphate removal. The prepared TAC@CS composite beads possess enhanced phosphate sorption capacity (SC) of 41.42 ± 0.071 mg/g than copper grafted chitosan (Cu@CS) composite, TAC and chitosan which were found to be 37.01 ± 0.803, 33.20 ± 0.650 and 7.24 ± 0.059 mg/g respectively. In batch mode, various adsorption influencing parameters like contact time, initial phosphate concentration, solution pH, co-anions and temperature were optimized for maximum phosphate sorption...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352867/preparation-surface-activity-and-colloidal-properties-of-the-ionic-complex-of-chitosan-with-hexadecyl-oligo-oxyethylene-hemisuccinate
#9
E V Lasareva, A I Chernuchina, G A Gabrielyan
Chitosan polyelectrolyte complex with high surface activity has been prepared by salt complexation of chitosan with hexadecyl-oligo-oxyethylene hemisuccinate (HOS), an anionic surfactant. Physicochemical properties of chitosan-HOS complex can be explained by unusual structure of HOS which has the polyoxyethylene chain located between the polar carboxyl head group and the hydrophobic alkyl tail. Aqueous solutions of chitosan-HOS complex are structured systems with pronounced thixotropic properties. The effect of content of hydrophobic exchanged groups on the solution properties of chitosan-HOS complex and various factors controlling the stability of oil-in-water emulsions in the presence of chitosan-HOS complex are studied...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352866/thermo-reversible-supramolecular-hydrogels-of-trehalose-type-diblock-methylcellulose-analogues
#10
Mao Yamagami, Hiroshi Kamitakahara, Arata Yoshinaga, Toshiyuki Takano
This paper describes the design and synthesis of new trehalose-type diblock methylcellulose analogues with nonionic, cationic, and anionic cellobiosyl segments, namely 1-(tri-O-methyl-cellulosyl)-4-[β-d-glucopyranosyl-(1→4)-β-d-glucopyranosyloxymethyl]-1H-1,2,3-triazole (1), 1-(tri-O-methyl-cellulosyl)-4-[(6-amino-6-deoxy-β-d-glucopyranosyl)-(1→4)- 6-amino-6-deoxy-β-d-glucopyranosyloxymethyl]-1H-1,2,3-triazole (2), and 4-(tri-O-methyl-cellulosyloxymethyl)-1-[β-d-glucopyranuronosyl-(1→4)-β-d-glucopyranuronosyl]-1H-1,2,3-triazole (3), respectively...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29351884/crucial-role-of-chelatable-iron-in-silver-nanoparticles-induced-dna-damage-and-cytotoxicity
#11
Agnieszka Grzelak, Maria Wojewódzka, Sylwia Meczynska-Wielgosz, Mariusz Zuberek, Dominika Wojciechowska, Marcin Kruszewski
Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction of mitochondria results in generation of superoxide anion radical (O2•-), which due to the relatively low chemical reactivity is rather unlikely to cause harmful effects triggered by nanoparticles. We show that treatment of HepG2 cells with silver nanoparticles (AgNPs) resulted in generation of H2O2 instead of O2•-, as measured by ROS specific mitochondrial probes. Moreover, addition of a selective iron chelator diminished AgNPs toxicity...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29351878/kinetic-studies-of-the-aop-radical-based-oxidative-and-reductive-destruction-of-pesticides-and-model-compounds-in-water
#12
Kristin K Clark, Stephen P Mezyk, Amberashley Abbott, James J Kiddle
Absolute second-order rate constants for hydroxyl radical (HO) reaction with four organophosphorus pesticides, malathion, parathion, fenthion and ethion, and a suite of model compounds of structure (EtO)2P(S)-X (where X = Cl, F, SH, SEt, OCH2CF3, OEt, NH2, and CH3) were measured using electron pulse radiolysis and transient absorption techniques. Specific values were determined for these four pesticides as k = (3.89 ± 0.28) x 109, (2.20 ± 0.15) x 109, (2.02 ± 0.15) x 109 and (2.93 ± 0...
December 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29351853/cardiac-biomarkers-as-sensitive-tools-to-evaluate-the-impact-of-xenobiotics-on-amphibians-the-effects-of-anionic-surfactant-linear-alkylbenzene-sulfonate-las
#13
Monica Jones-Costa, Lilian Franco-Belussi, Felipe Augusto Pinto Vidal, Nathália Penteado Gongora, Luciano Mendes Castanho, Cleoni Dos Santos Carvalho, Elaine Cristina Mathias Silva-Zacarin, Fabio Camargo Abdalla, Iolanda Cristina Silveira Duarte, Classius De Oliveira, Cristiane Ronchi de Oliveira, Raquel Fernanda Salla
Amphibian populations have been experiencing a drastic decline worldwide. Aquatic contaminants are among the main factors responsible for this decline, especially in the aquatic environment. The linear alkylbenzene sulfonate (LAS) is of particular concern, since it represents 84% of the anionic surfactants' trade. In Brazil, the maximal LAS concentration allowed in fresh waters is 0.5mgL-1, but its potential harmful effects in amphibians remain unknown. Therefore, this study aimed to analyze the effects of a sublethal concentration of LAS (0...
January 16, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29351723/mitochondrial-uncoupling-proteins-subtle-regulators-of-cellular-redox-signaling
#14
Petr Jezek, Blanka Holendová, Keith D Garlid, Martin Jaburek
SIGNIFICANCE: Mitochondria are the energetic, metabolic, redox and information signaling centers of the cell. Substrate pressure, mitochondrial network dynamics and cristae morphology state are integrated by the protonmotive force Δp or its potential component, ΔΨ, which are attenuated by proton backflux into the matrix, termed uncoupling. The mitochondrial uncoupling proteins (UCP1-5) play an eminent role in the regulation of each of the above aspects, being involved in numerous physiological events including redox signaling...
January 19, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29351191/anionic-water-cluster-polymers-h%C3%A2-o-18-oh-%C3%A2-n2n-is-stabilized-by-bis-2-2-bipyridine-cupric-chloride-cu-bipy-%C3%A2-cl
#15
E Liu, Fangfang Jian
Anionic water clusters have long been studied to infer properties of the bulk hydrated electron. In particular, the question of whether the excess electron is on the surface of the cluster or in the interior of the clusters has been the subject of much speculation. The successes of solid-state physics are built on exploiting the regularity of atomic arrangements in crystal. Describing the crystalline order of solids is relatively straightforward. Here we report the crystal structure of an anionic water cluster polymer [(H₂O)18(OH)₂]n2n- moiety that is stabilized by bis(2,2'-bipyridine) cupric chloride [Cu(bipy)₂Cl]- host...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29350930/curtin-hammett-driven-intramolecular-cyclization-of-heteroenyne-allenes-to-phenanthridine-fused-quinazoliniminiums
#16
Pamela S Filby, Sundeep Rayat
Intramolecular cyclization of the heteroenyne-allene, 2-((biphenyl-2-ylimino)methyleneamino)benzonitrile 1 to phenanthridine-fused quinazoliniminium salt PQ in the presence of a Lewis acid at room temperature involves formation of two new bonds: a C-C bond and a C-N bond. In this article, density functional theory (B3LYP and M06-2X) was employed in conjunction with 6-311G* basis set to gain insights into the mechanism of this cyclization reaction. The solvent effects were considered using Polarizable Continuum Model with nitromethane as the solvent...
January 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29350728/dual-chain-extension-effect-and-antibacterial-properties-of-biomolecules-interleaved-within-ldh-dispersed-into-pbs-by-in-situ-polymerization
#17
Grazia Totaro, Laura Sisti, Annamaria Celli, Irene Aloisio, Diana Di Gioia, Adam A Marek, Vincent Verney, Fabrice Leroux
Nanocomposites based on poly(butylene succinate) (PBS) and hydrotalcite-type anionic clays (HTs) organo-modified with biomolecules characterized by antibacterial and/or antioxidant activities, such as l-ascorbic acid (ASA), phloretic acid (HPP), l-tyrosine (TYR) and l-tryptophan (TRP), have been prepared by in situ polymerization. From XRD analysis and rheology experiments in a molten polymer state, intercalated HT hybrid platelets acting here as a hybrid filler are found to be well dispersed into polymers while providing a chain extension effect on PBS...
January 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29350717/fluoride-ion-binding-promoted-photoinduced-charge-separation-in-a-self-assembled-c60-alkyl-cation-bound-bis-crown-ether-oxoporphyrinogen-supramolecule
#18
Whitney A Webre, Habtom B Gobeze, Shuai Shao, Paul A Karr, Katsuhiko Ariga, Jonathan P Hill, Francis D'Souza
A bis-crown ether-oxoporphyrinogen was newly synthesized and self-assembled concurrently with C60 alkyl ammonium cations at the crown ether sites and F- anions (through hydrogen bonding) at the oxoporphyrinogen core. Ultrafast photoinduced charge transfer processes within the donor-acceptor conjugate were promoted by fluoride ion binding and this was established using various spectroscopic methods and transient absorption studies.
January 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29350518/development-of-self-healing-d-gluconic-acetal-based-supramolecular-ionogels-for-potential-use-as-smart-quasi-solid-electrochemical-materials
#19
Shipeng Chen, Baohao Zhang, Nanxiang Zhang, Fengsheng Ge, Bao Zhang, Xiaoji Wang, Jian Song
Formation of supramolecular ionic liquid gels (ionogels) induced by low-molecular mass gelators (LMMGs) is an efficient strategy to confine ionic liquids and the negligible influence of LMMGs on the electrochemical properties of ionic liquids makes ionogels ideal quasi-solid electrochemical materials. Furthermore, the stimuli-responsive and self-healing characters of the supramolecular gel can be utilized for the potential development of smart electrochemical materials. However, the poor mechanical properties of supramolecular ionogel reported so far limit their practical applications...
January 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29350234/dissociative-electron-attachment-and-anion-induced-dimerization-in-pyruvic-acid
#20
M Zawadzki, M Ranković, J Kočišek, J Fedor
We report partial cross sections for the dissociative electron attachment to pyruvic acid. A rich fragmentation dynamics is observed. Electronic structure calculations facilitate the identification of complex rearrangement reactions that occur during the dissociation. Furthermore, a number of fragment anions produced at electron energies close to 0 eV are observed, that cannot originate from single electron-molecule collisions. We ascribe their production to secondary reactions of the transient anions with neutral molecules...
January 19, 2018: Physical Chemistry Chemical Physics: PCCP
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