keyword
MENU ▼
Read by QxMD icon Read
search

Ionized

keyword
https://www.readbyqxmd.com/read/29169114/evaluation-of-antiparkinson-activity-of-ptupb-by-measuring-dopamine-and-its-metabolites-in-drosophila-melanogaster-lc-ms-ms-method-development
#1
Navya Lakkappa, Praveen T Krishnamurthy, Karthik Yamjala, Sung Hee Hwang, Bruce D Hammock, B Babu
Soluble epoxide hydrolase (sEH) inhibition is reported to elevate endogenous epoxyeicosatrienoic acids (EET's), which are known to play an important role in neuroprotection by inhibiting oxidative stress and neuroinflammation. In the present study, PTUPB, a dual inhibitor of sEH and COX-2, has been tested for its antiparkinson activity against rotenone (ROT) induced neurodegeneration in Drosophila model of Parkinson's disease (PD). To determine the efficacy and brain bioavailability of PTUPB a simple, rapid and sensitive LC-MS/MS method was developed and validated for the estimation of PTUPB (Method-I), dopamine (DA) and its metabolites (Method-II) in fly head...
November 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169113/a-rapid-and-simple-hplc-ms-ms-method-for-the-simultaneous-quantification-of-valproic-acid-and-its-five-metabolites-in-human-plasma-and-application-to-study-pharmacokinetic-interaction-in-chinese-epilepsy-patients
#2
Dingsheng Wen, Ziyi Chen, Chao Yang, Huanbin Liu, Hongliang Li, Juan Chen, Qiling Dai, Guoping Zhong, Jiaming Qin, Guanzhong Ni, Min Huang, Liemin Zhou, Xueding Wang
Valproic acid(VPA) is a classic drug that used to treat epilepsy in monotherapy or combination with other anticonvulsant drugs such as lamotrigine (LTG). Although it was reported that VPA could increase lamotrigine trough concentration in clinical practice, there was no report about the effect of LTG on the trough concentration of VPA and its main metabolites, such as 4-ene-VPA, 3-OH-VPA, 4-OH-VPA, 3-keto-VPA, 2-PGA which are related to the therapeutic and toxic effects of VPA. In this study, a simple and rapid method for the simultaneous determination of VPA and its five metabolites in human plasma using HPLC-MS/MS was developed for the first time...
November 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29168862/inhibition-of-advanced-glycation-endproducts-during-fish-sausage-preparation-by-transglutaminase-and-chitosan-oligosaccharides-induced-enzymatic-glycosylation
#3
Jing Wang, Long Zou, Fangzhou Yuan, Liangtao Lv, Shenglan Tian, Zhenxing Li, Hong Lin
Advanced glycation endproducts (AGEs) are the harmful products of non-enzymatic reactions in foods formed during the heating process. In order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied. The results indicated that the TGase/COS ratio of 1 : 1 could inhibit the formation of AGEs, showing especially a decreased N(ε)-carboxymethyl-lysine (CML) content and a twice higher inhibition rate (36...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168517/crossed-beam-polyatomic-reaction-dynamics-recent-advances-and-new-insights
#4
REVIEW
Huilin Pan, Kopin Liu, Adriana Caracciolo, Piergiorgio Casavecchia
Over the past ten years or so, great advances in our understanding of the dynamics of elementary (bimolecular) polyatomic reactions in the gas-phase have occurred. This has been made possible by critical improvements (a) in crossed molecular beam (CMB) instruments with rotating mass spectrometric detection and time-of-flight analysis, especially following the implementation of soft ionization (by tunable low energy electrons or vacuum-ultraviolet synchrotron radiation) for product detection with increased sensitivity and universal detection power, and (b) in REMPI-slice velocity map ion imaging (VMI) detection techniques in pulsed CMB experiments for obtaining product pair-correlated information through high-resolution measurements directly in the center of mass system...
November 23, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29168328/coating-of-optical-fiber-with-a-smart-thermosensitive-polymer-for-the-separation-of-phthalate-esters-by-solid-phase-microextraction
#5
Hamid Hashemi-Moghaddam, Setayesh Maddah
A solid-phase microextraction fiber was prepared by coating an optical fiber with a temperature-sensitive polymer to determine phthalate esters. N-Isopropylacrylamide and N,N'-methylenebisacrylamide were used as the monomer and the cross linker, respectively. The fabricated fiber was characterized by FTIR spectroscopy, thermogravimetric analysis, and scanning electron microscopy. During extraction, important factors such as extraction time, pH, temperature, and ionic strength were optimized. The fabricated fiber, which is firm, inexpensive, stable, and efficient, is a vital material used in solid-phase microextraction...
November 23, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29168186/adipokines-and-inflammation-markers-and-risk-of-differentiated-thyroid-carcinoma-the-epic-study
#6
Laure Dossus, Silvia Franceschi, Carine Biessy, Anne-Sophie Navionis, Ruth C Travis, Elisabete Weiderpass, Augustin Scalbert, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Agnès Fournier, Renee T Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Antonia Trichopoulou, Carlo La Vecchia, Eleni Peppa, Rosario Tumino, Salvatore Panico, Domenico Palli, Claudia Agnoli, Paolo Vineis, Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Raul Zamora-Ros, María-Dolores Chirlaque, Eva Ardanaz, Maria-Jose Sánchez, Jose Ramón Quirós, Miren Dorronsoro, Maria Sandström, Lena Maria Nilsson, Julie A Schmidt, Kay-Tee Khaw, Konstantinos K Tsilidis, Dagfinn Aune, Elio Riboli, Sabina Rinaldi
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin(IL)-6, IL-10 and TNF-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29167269/ring-finger-protein-126-rnf126-suppresses-ionizing-radiation-induced-p53-binding-protein-1-53bp1-foci-formation
#7
Nam Soo Lee, Hae Ryung Chang, Soomi Kim, Jae-Hoon Ji, Joorak Lee, Hyun Ji Lee, Yoojeong Seo, Misun Kang, Joo Seok Han, Kyungjae Myung, Yonghwan Kim, Hongtae Kim
Cells have evolved sophisticated mechanisms to maintain genomic integrity in response to DNA damage. Ionizing radiation (IR) induced DNA damage results in the formation of IR induced foci (iRIF) in the nucleus. The iRIF formation is part of the DNA damage response (DDR), which is an essential signaling cascade that must be strictly regulated because either the loss of or an augmented DDR leads to loss of genome integrity. Accordingly, negative regulation of the DDR is as critical as its activation. In this study, we have identified ring finger protein 126 (RNF126) as a negative regulator of the DDR from a screen of iRIF containing 53BP1...
November 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29166625/ambient-surface-mass-spectrometry-ion-mobility-spectrometry-of-intact-proteins
#8
REVIEW
Rian L Griffiths, Klaudia I Kocurek, Helen J Cooper
Ambient surface mass spectrometry encompasses a broad range of sampling and ionization techniques. To date, only a small subset of these, based on liquid microjunction extraction, have proven suitable for intact protein analysis from thin tissue sections. Liquid extraction surface analysis shows particular promise for this application. Recently, a range of ion mobility spectrometry approaches have been coupled with ambient mass spectrometry. Improvements in signal-to-noise ratios, decreased chemical noise and separation of molecular classes have been described for the analysis of various biological substrates...
November 18, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29166118/photofragmentation-of-gas-phase-acetic-acid-and-acetamide-clusters-in-the-vacuum-ultraviolet-region
#9
Marta Berholts, Hanna Myllynen, Kuno Kooser, Eero Itälä, Sari Granroth, Helena Levola, Joakim Laksman, Shabnam Oghbaiee, Bart Oostenrijk, Ergo Nõmmiste, Edwin Kukk
Photofragmentation of gas-phase acetamide and acetic acid clusters produced by a supersonic expansion source has been studied using time-of-flight mass spectrometry and the partial ion yield (PIY) technique combined with tunable vacuum-ultraviolet synchrotron radiation. Appearance energies of the clusters and their fragments were experimentally determined from the PIY measurements. The effect of clusterization conditions on the formation and fragmentation of acetic acid clusters was investigated. Ab initio quantum mechanical calculations were performed on both samples' dimers to find their neutral and ionized geometries as well as proton transfer energy barriers leading to the optimal geometries...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166101/self-consistency-of-electron-thf-cross-sections-using-electron-swarm-techniques
#10
M J E Casey, J de Urquijo, L N Serkovic Loli, D G Cocks, G J Boyle, D B Jones, M J Brunger, R D White
The drift velocity and first Townsend ionization coefficient of electrons in gaseous tetrahydrofuran are measured over the range of reduced electric fields 4-1000 Td using a pulsed-Townsend technique. The measured drift velocities and Townsend ionization coefficients are subsequently used, in conjunction with a multi-term Boltzmann equation analysis, as a further discriminative assessment on the accuracy and completeness of a recently proposed set of electron-THF vapor cross sections. In addition, the sensitivity of the transport coefficients to uncertainties in the existing cross sections is presented...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166087/dft-mrci-hamiltonian-for-odd-and-even-numbers-of-electrons
#11
Adrian Heil, Christel M Marian
DFT/MRCI is a well-established method of Grimme and Waletzke [J. Chem. Phys. 111, 5645 (1999)] combining density functional theory and multireference configuration interaction. It was later redesigned by Lyskov, Kleinschmidt, and Marian [J. Chem. Phys. 144, 034104 (2016)] to provide a better treatment of bi-chromophores while treating all other systems as well as Grimme's version did by computing individual energy shifts for each state function of a configuration. But all previous operators lack the ability to compute states with an odd number of electrons (doublet and quartet states)...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166077/low-energy-photoelectron-transmission-through-aerosol-overlayers
#12
Stavros Amanatidis, Bruce L Yoder, Ruth Signorell
The transmission of low-energy (<1.8 eV) photoelectrons through the shell of core-shell aerosol particles is studied for liquid squalane, squalene, and di-ethyl-hexyl-sebacate shells. The photoelectrons are exclusively formed in the core of the particles by two-photon ionization. The total photoelectron yield recorded as a function of shell thicknesses (1-80 nm) shows a bi-exponential attenuation. For all substances, the damping parameter for shell thicknesses below 15 nm lies around 8 to 9 nm and is tentatively assigned to the electron attenuation length at electron kinetic energies of ≲1 eV...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166017/bond-dissociation-energies-of-tungsten-molecules-wc-wsi-ws-wse-and-wcl
#13
Andrew Sevy, Robert F Huffaker, Michael D Morse
Resonant two-photon ionization spectroscopy has been used to locate predissociation thresholds in WC, WSi, WS, WSe, and WCl, allowing bond dissociation energies to be measured for these species. Because of the high degree of vibronic congestion in the observed spectra, it is thought that the molecules dissociate as soon as the lowest separated atom limit is exceeded. From the observed predissociation thresholds, dissociation energies are assigned as D0(WC) = 5.289(8) eV, D0(WSi) = 3.103(10) eV, D0(WS) = 4.935(3) eV, D0(WSe) = 4...
November 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29166005/self-assembly-of-tetrameric-and-hexameric-terpyridine-based-macrocycles-using-cd-ii-zn-ii-and-fe-ii
#14
Lei Wang, Zhe Zhang, Xin Jiang, Jennifer A Irvin, Changlin Liu, Ming Wang, Xiaopeng Li
The self-assembly behavior of a tritopic 2,2':6',2″-terpyridine (tpy) ligand with Cd(II), Zn(II), and Fe(II) has been exploited herein to generate a series of tetrameric and hexameric macrocycles. The main advantage of using such transition metals with an octahedral coordination geometry is their distinct coordination abilities (e.g., binding strength and reversibility). With the same ligand, this study reveals that the supramolecular structural variation between tetrameric and hexameric macrocycle architectures can be precisely controlled using different metal ions with the same coordination geometry...
November 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29165995/magnetic-particle-imaging-for-highly-sensitive-quantitative-and-safe-in-vivo-gut-bleed-detection-in-a-murine-model
#15
Elaine Y Yu, Prashant Chandrasekharan, Ran Berzon, Zhi Wei Tay, Xinyi Y Zhou, Amit P Khandhar, R Matthew Ferguson, Scott J Kemp, Bo Zheng, Patrick W Goodwill, Michael F Wendland, Kannan M Krishnan, Spencer Behr, Jonathan Carter, Steven M Conolly
Gastrointestinal (GI) bleeding causes more than 300,000 hospitalizations per year in the United States. Imaging plays a crucial role in accurately locating the source of the bleed for timely intervention. Magnetic Particle Imaging (MPI) is an emerging clinically translatable imaging modality that images superparamagnetic iron-oxide (SPIO) tracers with extraordinary contrast and sensitivity. This linearly quantitative modality has zero background tissue signal and zero signal depth attenuation. MPI is also safe: there is zero ionizing radiation exposure to the patient and clinically approved tracers can be used with MPI...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29165687/investigation-of-the-relationship-between-radiation-dose-and-gene-mutations-and-fusions-in-post-chernobyl-thyroid-cancer
#16
Alexey A Efanov, Alina V Brenner, Tetiana I Bogdanova, Lindsey M Kelly, Pengyuan Liu, Mark P Little, Abigail I Wald, Maureen Hatch, Liudmyla Y Zurnadzy, Marina N Nikiforova, Vladimir Drozdovitch, Kiyohiko Mabuchi, Mykola D Tronko, Stephen J Chanock, Yuri E Nikiforov
Background: Exposure to ionizing radiation during childhood is a well-established risk factor for thyroid cancer. However, the genetic mechanisms of radiation-associated carcinogenesis remain not fully understood. Methods: In this study, we used targeted next-generation sequencing and RNA-Seq to study 65 papillary thyroid cancers (PTCs) from patients in the Ukrainian-American cohort with measurement-based iodine-131 (I-131) thyroid doses received as a result of the Chernobyl accident...
November 18, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29165554/the-effect-of-1-5%C3%A2-t-cardiac-magnetic-resonance-on-human-circulating-leucocytes
#17
William R Critchley, Anna Reid, Julie Morris, Josephine H Naish, John P Stone, Alexandra L Ball, Triin Major, David Clark, Nick Waldron, Christien Fortune, Jakub Lagan, Gavin A Lewis, Mark Ainslie, Erik B Schelbert, Daniel M Davis, Matthias Schmitt, James E Fildes, Christopher A Miller
Aims: Investigators have proposed that cardiovascular magnetic resonance (CMR) should have restrictions similar to those of ionizing imaging techniques. We aimed to investigate the acute effect of 1.5 T CMR on leucocyte DNA integrity, cell counts, and function in vitro, and in a large cohort of patients in vivo. Methods and results: In vitro study: peripheral blood mononuclear cells (PBMCs) were isolated from healthy volunteers, and histone H2AX phosphorylation (γ-H2AX) expression, leucocyte counts, and functional parameters were quantified using flow cytometry under the following conditions: (i) immediately following PBMC isolation, (ii) after standing on the benchside as a temperature and time control, (iii) after a standard CMR scan...
November 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29165327/effects-of-dl-3-n-butylphthalide-on-cerebral-ischemia-infarction-in-rat-model-by-mass-spectrometry-imaging
#18
Run-Zhe Liu, Chao-Xin Fan, Zhi-Lin Zhang, Xin Zhao, Yi Sun, Hui-Hui Liu, Zong-Xiu Nie, Xiao-Ping Pu
Dl-3-n-butylphthalide (NBP) is a drug that is used in the treatment of ischaemic stroke. However, to the best of our knowledge, there are no systematic studies investigating the effects of dl-3-n-butylphtalide on the brain metabolism of small molecules. In this study, we first investigated the effects of dl-3-n-butylphthalide on the spatial distribution of small molecules in the brains of rats with permanent middle cerebral artery occlusion (pMCAO) using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) imaging...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29165316/residual-%C3%AE-h2ax-foci-induced-by-low-dose-x-ray-radiation-in-bone-marrow-mesenchymal-stem-cells-do-not-cause-accelerated-senescence-in-the-progeny-of-irradiated-cells
#19
Margarita Pustovalova, Тatiana A Astrelina, Anna Grekhova, Natalia Vorobyeva, Anastasia Tsvetkova, Taisia Blokhina, Victoria Nikitina, Yulia Suchkova, Daria Usupzhanova, Vitalyi Brunchukov, Irina Kobzeva, Тatiana Karaseva, Ivan V Ozerov, Aleksandr Samoylov, Andrey Bushmanov, Sergey Leonov, Evgeny Izumchenko, Alex Zhavoronkov, Dmitry Klokov, Andreyan N Osipov
Mechanisms underlying the effects of low-dose ionizing radiation (IR) exposure (10-100 mGy) remain unknown. Here we present a comparative study of early (less than 24h) and delayed (up to 11 post-irradiation passages) radiation effects caused by low (80 mGy) vs intermediate (1000 mGy) dose X-ray exposure in cultured human bone marrow mesenchymal stem cells (MSCs). We show that γН2АХ foci induced by an intermediate dose returned back to the control value by 24 h post-irradiation. In contrast, low-dose irradiation resulted in residual γН2АХ foci still present at 24 h...
November 21, 2017: Aging
https://www.readbyqxmd.com/read/29165113/alteration-in-plasma-free-amino-acid-levels-and-its-association-with-gout
#20
M H Mahbub, Natsu Yamaguchi, Hidekazu Takahashi, Ryosuke Hase, Hiroki Amano, Mikiko Kobayashi-Miura, Hideyuki Kanda, Yasuyuki Fujita, Hiroshi Yamamoto, Mai Yamamoto, Shinya Kikuchi, Atsuko Ikeda, Naoko Kageyama, Mina Nakamura, Yasutaka Ishimaru, Hiroshi Sunagawa, Tsuyoshi Tanabe
BACKGROUND: Studies on the association of plasma-free amino acids with gout are very limited and produced conflicting results. Therefore, we sought to explore and characterize the plasma-free amino acid (PFAA) profile in patients with gout and evaluate its association with the latter. METHODS: Data from a total of 819 subjects (including 34 patients with gout) undergoing an annual health examination program in Shimane, Japan were considered for this study. Venous blood samples were collected from the subjects and concentrations of 19 plasma amino acids were determined by high-performance liquid chromatography-electrospray ionization-mass spectrometry...
March 16, 2017: Environmental Health and Preventive Medicine
keyword
keyword
120151
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"