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https://www.readbyqxmd.com/read/28743125/surfactant-protein-b-suppresses-lung-cancer-progression-by-inhibiting-secretory-phospholipase-a2-activity-and-arachidonic-acid-production
#1
Sungmin Lee, Daehoon Kim, JiHoon Kang, EunGi Kim, Wanyeon Kim, HyeSook Youn, BuHyun Youn
BACKGROUND/AIMS: Radiotherapy is applied to patients with inoperable cancer types including advanced stage non-small cell lung cancer (NSCLC) and radioresistance functions as a critical obstacle in radiotherapy. This study was aimed to investigate the mechanism of radioresistance regulated by surfactant protein B (SP-B). METHODS: To investigate the role of SP-B in radioresistance, ΔSFTPB A549 cell line was established and SP-B expression was analyzed. In response to ionizing radiation (IR), the change of SP-B expression was analyzed in A549 and NCI-H441 cell lines...
July 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28743076/lc-ms-ms-esi-method-for-simultaneous-quantification-of-darolutamide-and-its-active-metabolite-orm-15341-in-mice-plasma-and-its-application-to-a-pharmacokinetic-study
#2
Sreekanth Dittakavi, Pavan Kumar V S P Nagasuri, Suresh P Sulochana, Syed Mohd Saim, Sadanand R Mallurwar, Mohd Zainuddin, Purushottam Dewang, Sriram Rajagopal, Ramesh Mullangi
A sensitive and rapid LC-MS/MS method was developed and validated for the simultaneous quantitation of darolutamide and its active metabolite i.e. ORM-15341 in 50μL mice plasma using bicalutamide as an internal standard (I.S.) as per regulatory guidelines. Sample processing was accomplished through liquid-liquid extraction. Chromatographic separation was achieved using an Atlantis C18 column with an isocratic mobile phase comprising 0.2% formic acid:acetonitrile (35:65, v/v) at a flow rate of 0.8mL/min within 2...
July 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28742863/antibacterial-activity-of-tannins-isolated-from-sapium-baccatum-extract-and-use-for-control-of-tomato-bacterial-wilt
#3
Thuy Thu Vu, Hun Kim, Vu Khac Tran, Hoang Dinh Vu, Tien Xuan Hoang, Jae Woo Han, Yong Ho Choi, Kyoung Soo Jang, Gyung Ja Choi, Jin-Cheol Kim
In the search for new antibacterial agents from natural sources, we revealed that a crude methanol extract of Sapium baccatum was highly active against Ralstonia solanacearum, a causal agent of a serious disease called bacterial wilt of tomato. The bioassay-guided fractionation of this extract resulted in the isolation of seven known active compounds, including gallic acid, methyl gallate, corilagin, tercatain, chebulagic acid, chebulinic acid, and quercetin 3-O-α-L-arabinopyranoside. Their chemical structures were determined by electrospray ionization mass spectrometry and nuclear magnetic resonance spectroscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28742650/reliable-and-easy-to-use-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-analysis-of-fluconazole-isavuconazole-itraconazole-hydroxy-itraconazole-posaconazole-and-voriconazole-in-human-plasma-and-serum
#4
Carsten Müller, David Gehlen, Cornelia Blaich, Domenik Prozeller, Blasius Liss, Thomas Streichert, Martin H J Wiesen
BACKGROUND: A fast and easy-to-use liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification of six triazoles (fluconazole (FLZ), isavuconazole (ISZ), itraconazole (ITZ), hydroxy-itraconazole (OH-ITZ), posaconazole (PSZ), voriconazole (VRZ)) in human plasma and serum was developed and validated for therapeutic drug monitoring (TDM). METHODS: Sample preparation was based on protein precipitation with acetonitrile and subsequent centrifugation...
July 24, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28742468/single-ct-scan-prolongs-survival-by-extending-cancer-latency-in-trp53-heterozygous-mice
#5
Jennifer A Lemon, Nghi Phan, Douglas R Boreham
There is growing concern over the effects of medical diagnostic procedures on cancer risk. Although numerous studies have demonstrated that low doses of ionizing radiation can have protective effects including reduced cancer risk and increasing lifespan, the hypothesis that any radiation exposure increases cancer risk still predominates. In this study, we investigated cancer development and longevity of cancer-prone Trp53(+/-) mice exposed at 7-8 weeks of age to a single 10 mGy dose from either a diagnostic CT scan or gamma radiation...
July 25, 2017: Radiation Research
https://www.readbyqxmd.com/read/28742357/size-effect-in-the-ionization-energy-of-pah-clusters
#6
Christine Joblin, Léo Dontot, Gustavo A Garcia, Fernand Spiegelman, Mathias Rapacioli, Laurent Nahon, Pascal Parneix, Thomas Pino, Philippe Brechignac
We report the first experimental measurement of the near-threshold photo-ionization spectra of polycyclic aromatic hydrocarbon clusters made of pyrene C16H10 and coronene C24H12, obtained using imaging photoelectron photoion coincidence spectrometry with a VUV synchrotron beamline. The experimental results of the ionization energy are confronted to calculated ones obtained from simulations using dedicated electronic structure treatment for large ionized molecular clusters. Experiment and theory consistently find a decrease of the ionization energy with cluster size...
July 25, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28742123/molecular-and-maldi-tof-identification-of-ticks-and-tick-associated-bacteria-in-mali
#7
Adama Zan Diarra, Lionel Almeras, Maureen Laroche, Jean-Michel Berenger, Abdoulaye K Koné, Zakaria Bocoum, Abdoulaye Dabo, Ogobara Doumbo, Didier Raoult, Philippe Parola
Ticks are considered the second vector of human and animal diseases after mosquitoes. Therefore, identification of ticks and associated pathogens is an important step in the management of these vectors. In recent years, mass spectrometry of the laser disorder / matrix assisted ionization (MALDI-TOF MS) has been reported as a promising method for the identification of arthropods including ticks. The objective of this study was to improve the conditions for the preparation of tick samples for their identification by MALDI-TOF MS from field-collected ethanol-stored Malian samples and to evaluate the capacity of this technology to distinguish infected and uninfected ticks...
July 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28742061/test-study-of-boron-nitride-as-a-new-detector-material-for-dosimetry-in-high-energy-photon-beams
#8
Daniela Poppinga, Jannik Halbur, Sarah Lemmer, Bjoern Delfs, Dietrich Harder, Hui Khee Looe, Bjoern Poppe
The aim of this test study is to check whether boron nitride (BN) might be applied as a detector material in high energy photon-beam dosimetry. Boron nitride is a compound of boron and nitrogen and exists in various crystalline forms. Hexagonal boron nitride (h-BN) possesses high mobility of the electrons and holes as well as a high volume resistivity, so that ionizing radiation in the clinical range of the dose rate can be expected to produce a measurable electrical current at low background current. Due to the low atomic numbers of its atomic constituents, its density (2...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28741984/multiple-ct-scans-extend-lifespan-by-delaying-cancer-progression-in-cancer-prone-mice
#9
Jennifer A Lemon, Nghi Phan, Douglas R Boreham
Computed tomography (CT) scans are a routine diagnostic imaging technique that utilize low-energy X rays with an average absorbed dose of approximately 10 mGy per clinical whole-body CT scan. The growing use of CT scans in the clinic has raised concern of increased carcinogenic risk in patients exposed to ionizing radiation from diagnostic procedures. The goal of this study was to better understand cancer risk associated with low-dose exposures from CT scans. Historically, low-dose exposure preceding a larger challenge dose increases tumor latency, but does little to impact tumor frequency in Trp53(+/-) mice...
July 25, 2017: Radiation Research
https://www.readbyqxmd.com/read/28741857/surface-cross-linked-ultra-high-molecular-weight-polyethylene-by-emulsified-diffusion-of-dicumyl-peroxide
#10
Sanem Kayandan, Brinda N Doshi, Ebru Oral, Orhun K Muratoglu
Cross-linking improves the wear resistance of ultrahigh molecular weight polyethylene (UHMWPE) used in hip and knee implants. Free radicals, generated by ionizing radiation or chemically, react to form cross-links. Limiting cross-linking to the articulating surface of the implant is desirable to enable high wear resistance on the surface and higher strength and toughness in the bulk. We investigated the diffusion of emulsified dicumyl peroxide (DCP) into vitamin E-blended UHMWPE (0.1 and 0.3 wt. % vitamin-E) with subsequent thermal decomposition in situ to obtain surface cross-linking with the objective of achieving surface wear rate equivalent or lower than that of current clinically available materials...
July 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28741641/highly-oriented-langmuir-blodgett-film-of-silver-cuboctahedra-as-an-effective-matrix-free-sample-plate-for-surface-assisted-laser-desorption-ionization-mass-spectrometry
#11
Tsung-Rong Kuo, Yin-Chien Chen, Chiung-I Wang, Tzu-Hau Shen, Hong-Yi Wang, Xi-Yu Pan, Di-Yan Wang, Chien-Chung Liou, Yi-Hsuan Chang, Yi-Chia Chen, Yueh-Hsiu Wu, Yun-Ru Liu, Yun-Ho Lin, Cho-Chun Hu, Chia-Chun Chen
The design of a homogeneous sample plate to solve the sweet heating spot issues is the key step to expand the applicability of surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). Herein, large-scale and highly oriented Langmuir-Blodgett (LB) films of uniform silver nanocrystals have been fabricated as a highly efficient and matrix-free sample plate for SALDI MS. Three individual silver nanocrystals (cubes, cuboctahedra and octahedra) assembled LB films have been applied as the sample plates for glucose detection by SALDI MS without an additional matrix...
July 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28741502/immune-priming-of-the-tumor-microenvironment-by-radiation
#12
REVIEW
Wen Jiang, Charles K Chan, Irving L Weissman, Betty Y S Kim, Stephen M Hahn
Ionizing irradiation can induce a multitude of alterations within the tumor microenvironment. Unlike targeted therapies, radiation delivered to the tumor bed can prompt phenotypic changes in both normal stromal and cancer cells, leading to molecular and physiological alterations within the tumor microenvironment. These environmental modulations directly influence the degree of immunogenicity of the tumor microenvironment and may ultimately affect tumor responsiveness to cancer immunotherapies. Here we review the preclinical evidence for tumor microenvironment-mediated immune suppression and how radiation can modulate immune properties within a tumor...
November 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28741367/radiotherapy-synergizes-with-the-hypoxia-activated-prodrug-evofosfamide-in-vitro-and-in-vivo-studies
#13
Yoichi Takakusagi, Shun Kishimoto, Naz Sarwat, Shingo Matsumoto, Keita Saito, Charles Hart, James B Mitchell, Murali K Cherukuri
AIMS: Evofosfamide (TH-302) is a hypoxia-activated prodrug (HAP) which releases the DNA damaging bromo-isophosphoramide (Br-IPM) moiety selectively under hypoxic conditions. Since solid tumors are known to have hypoxic regions, HAPs in combination with chemotherapy or radiotherapy will be beneficial. We tested the oxygen dependence of the release kinetics of Br-IPM using Electron Paramagnetic Resonance (EPR) with spin trapping by monitoring the redox-cycling the nitroimidazole moiety of TH-302 and oxygen dependence of TH-302 on in vitro cytotoxicity at different levels of hypoxia was also examined...
July 25, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28741297/maldi-ft-icr-ms-for-archaeological-lipid-residue-analysis
#14
Ester Oras, Signe Vahur, Sven Isaksson, Ivari Kaljurand, Ivo Leito
Soft-ionization methods are currently at the forefront of developing novel methods for analysing degraded archaeological organic residues. Here we present little-used soft ionisation method of matrix assisted laser desorption/ionization - Fourier transform - ion cyclotron resonance - mass spectrometry (MALDI-FT-ICR-MS) for the identification of archaeological lipid residues. It is a high-resolution and sensitive method with low limits of detection capable of identifying lipid compounds in small concentrations, thus providing a highly potential new technique for the analysis of degraded lipid components...
July 24, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28741125/identification-of-carboxylate-phosphate-and-phenoxide-functionalities-in-deprotonated-molecules-related-to-drug-metabolites-via-ion-molecule-reactions-with-water-and-diethylhydroxyborane
#15
Hanyu Zhu, Xin Ma, John Y Kong, Minli Zhang, Hilkka I Kenttämaa
Tandem mass spectrometry based on ion-molecule reactions has emerged as a powerful tool for structural elucidation of ionized analytes. However, most currently used reagents were designed to react with protonated analytes, making them suboptimal for acidic analytes that are preferentially detected in negative ion mode. In this work we demonstrate that the phenoxide, carboxylate, and phosphate functionalities can be identified in deprotonated molecules by use of a combination of two reagents, diethylmethoxyborane (DEMB) and water...
July 24, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28741109/multi-analyte-method-development-for-analysis-of-brominated-flame-retardants-bfrs-and-pbde-metabolites-in-human-serum
#16
Dasheng Lu, Yu'e Jin, Chao Feng, Dongli Wang, Yuanjie Lin, Xinlei Qiu, Qian Xu, Yimin Wen, Jianwen She, Guoquan Wang, Zhijun Zhou
Commonly, analytical methods measuring brominated flame retardants (BFRs) of different chemical polarities in human serum are labor consuming and tedious. Our study used acidified diatomaceous earth as solid-phase extraction (SPE) adsorbent and defatting material to simultaneously determine the most abundant BFRs and their metabolites with different polarities in human serum samples. The analytes include three types of commercial BFRs, tetrabromobisphenol A (TBBPA), hexabromocyclododecane (HBCD) isomers, and polybrominated biphenyl ethers (PBDEs), and dominant hydroxylated BDE (OH-PBDE) and methoxylated BDE (MeO-PBDE) metabolites of PBDEs...
July 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28741108/automated-clean-up-separation-and-detection-of-polycyclic-aromatic-hydrocarbons-in-particulate-matter-extracts-using-a-2d-lc-2d-gc-system-a-method-translation-from-two-fids-to-two-ms-detectors
#17
Hwanmi Lim, Trifa M Ahmed, Christoffer Bergvall, Roger Westerholm
An online two-dimensional (2D) liquid chromatography/2D gas chromatography system with two mass-selective detectors has been developed on the basis of a previous system with two flame ionization detectors. The method translation involved the change of carrier gas from hydrogen to helium, column dimension and detectors. The 2D system with two mass-selective detectors was validated with use of polycyclic aromatic hydrocarbon (PAH) standards and two standard reference materials from air and diesel exhaust. Furthermore, the system was applied to a real sample, wood smoke particulates...
July 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28740727/structure-modeling-of-human-tyrosyl-dna-phosphodiesterase-1-and-screening-for-its-inhibitors
#18
I V Gushchina, D K Nilov, A L Zakharenko, O I Lavrik, V K Švedas
The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) represents a potential molecular target for anticancer therapy. A human Tdp1 model has been constructed using the methods of quantum and molecular mechanics, taking into account the ionization states of the amino acid residues in the active site and their interactions with the substrate and competitive inhibitors. The oligonucleotide- and phosphotyrosine-binding cavities important for the inhibitor design have been identified in the enzyme's active site...
April 2017: Acta Naturae
https://www.readbyqxmd.com/read/28740677/assessment-of-thoracic-vasculature-in-patients-with-central-bronchogenic-carcinoma-by-unenhanced-magnetic-resonance-angiography-comparison-between-2d-free-breathing-truefisp-2d-breath-hold-truefisp-and-3d-respiratory-triggered-space
#19
Lili Wang, Peng Lv, Shuohui Yang, Mengsu Zeng, Jiang Lin
BACKGROUND: Preoperative assessment of the integrity of major thoracic vessels in central bronchogenic carcinoma is vital for tumor staging and treatment planning. Contrast-enhanced CT is currently the first choice of modality for this purpose in clinical practice with limitations including exposure to ionizing radiation and the use of iodinated contrast material. MRI has been increasingly employed for the staging of lung cancer. More recently, unenhanced magnetic resonance angiography (MRA) which is totally non-invasive and contrast-free has been reported able to show thoracic vessels...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28739797/unraveling-drug-penetration-of-echinocandin-antifungals-at-the-site-of-infection-in-an-intra-abdominal-abscess-model
#20
Yanan Zhao, Brendan Prideaux, Yoji Nagasaki, Min Hee Lee, Pei-Yu Chen, Landry Blanc, Hsinpin Ho, Cornelius J Clancy, Minh Hong Nguyen, Véronique Dartois, David S Perlin
Intra-abdominal candidiasis (IAC) is a prominent invasive fungal infection associated with high mortality. Prompt antifungal therapy and source control are crucial for successful treatment. Echinocandin antifungal drugs are first-line agents. Yet, their clinical effectiveness is highly variable with known potential for breakthrough resistance, and little is known about drug exposure at the site of infection. Using matrix-assisted desorption/ionization mass spectrometry imaging technology, we investigated the spatial and quantitative distribution in tissue lesions for two echinocandin drugs, micafungin and CD101, in a clinically relevant IAC mouse model...
July 24, 2017: Antimicrobial Agents and Chemotherapy
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