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Gata 3 breast cancer

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https://www.readbyqxmd.com/read/28700421/atypical-proliferative-borderline-serous-tumor-in-the-brain-a-case-report
#1
Deyin Xing, Erik G Jenson, Christopher A Zwick, Fausto J Rodriguez, Robert J Kurman
A 59-year-old woman with a remote history of invasive ductal carcinoma of the breast was found on a follow-up computed tomography scan of her brain to have a 1-cm lesion in the right frontal lobe in 2008. In the ensuing years, before her current admission, multiple imaging studies of the brain revealed that the lesion was stable and it was, therefore, interpreted as a small area of encephalomalacia related to a thrombosed cortical vein, a cavernoma, or treated metastatic breast cancer. In 2013, the patient underwent a bilateral salpingo-oophorectomy for ovarian tumors that were diagnosed as bilateral serous cystadenofibromas...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28599307/morin-promotes-prostate-cancer-cells-chemosensitivity-to-paclitaxel-through-mir-155-gata3-axis
#2
Bin Li, Xunbo Jin, Huilin Meng, Bo Hu, Tao Zhang, Jiang Yu, Shaoan Chen, Xudong Guo, Weiguo Wang, Wei Jiang, Jin Wang
Paclitaxel is a first-line microtubule-stabilizing drug in treating prostate cancer. However, most patients develop resistance and experience relapse. Morin (3,5,7,20,40-pentahydroxyflavone) is an anti-tumor flavonoid in a numerous types of cancer cells including breast, ovarian and lung cancers. We therefore researched the effects of morin as an adjuvant to paclitaxel in in treating DU145 and PC-3 cells in vitro and DU145 derived prostate cancers in nude mice models. The chemosensitivities of these cells to the treatments of morin and paclitaxel were tested through viability assays utilizing cell counting kit 8 (CCK-8) and apoptosis assays through flow cytometry analyses...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28490464/perioperative-cox-2-and-%C3%AE-adrenergic-blockade-improves-metastatic-biomarkers-in-breast-cancer-patients-in-a-phase-ii-randomized-trial
#3
Lee Shaashua, Maytal Shabat-Simon, Rita Haldar, Pini Matzner, Oded Zmora, Moshe Shabtai, Eran Sharon, Tanir Allweis, Iris Barshack, Lucile Hayman, Jesusa Arevalo, Jeffrey Ma, Maya Horowitz, Steven Cole, Shamgar Ben-Eliyahu
Purpose: Translational studies suggest that excess perioperative release of catecholamines and prostaglandins may facilitate metastasis and reduce disease-free survival. This trial tested the combined perioperative blockade of these pathways in breast cancer patients.Experimental Design: In a randomized placebo-controlled biomarker trial, 38 early-stage breast cancer patients received 11 days of perioperative treatment with a β-adrenergic antagonist (propranolol) and a COX-2 inhibitor (etodolac), beginning 5 days before surgery...
August 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28476053/transmission-of-donor-derived-breast-carcinoma-as-a-recurrent-mass-in-a-keratolimbal-allograft
#4
Audra K Miller, Jonathan W Young, David J Wilson, Jennifer Dunlap, Winston Chamberlain
PURPOSE: To report a case of local transmission of invasive lobular carcinoma from a donor to a recipient in a keratolimbal allograft after cessation of systemic immunosuppressive therapy. METHODS: This is a case report including the clinicopathologic findings. Sections of the donor breast tumor and recipient conjunctival lesions were stained with hematoxylin and eosin. Immunohistochemical studies were performed using pancytokeratin, CK7, CK20, CAM 5.2, CD138, TTF1, estrogen receptor, progesterone receptor, GATA-3, GCDFP-15, and mammaglobin...
June 2017: Cornea
https://www.readbyqxmd.com/read/28470571/immunohistochemical-analysis-of-the-expression-of-breast-markers-in-basal-like-breast-carcinomas-defined-as-triple-negative-cancers-expressing-keratin-5
#5
Tamás Zombori, Gábor Cserni
Estrogen and progesterone receptors are possible markers for suggesting a mammary origin of metastatic carcinoma, but are useless in cases of triple negative breast cancers (TNBC). Five other potential markers of breast origin were investigated on tissue microarrays in a series of TNBCs showing keratin 5 expression, consistent with a basal-like phenotype. GATA-3 staining was observed in 82 of 115 triple negative cases (71.3%) including 23 cases with >5% staining. Mammaglobin staining was detected in 30 cases (26...
May 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28428285/characterisation-of-gata3-expression-in-invasive-breast-cancer-differences-in-histological-subtypes-and-immunohistochemically-defined-molecular-subtypes
#6
Shao Xian Tang, Bao Hua Yu, Xiao Li Xu, Yu Fan Cheng, Xiao Yu Tu, Hong Fen Lu, Rui Bi, Xiang Jie Sun, Ruo Hong Shui, Wen Tao Yang
AIMS: GATA-binding protein 3 (GATA3) is a sensitive and relatively specific marker in breast and urothelial carcinomas. Its diagnostic utility in primary and metastatic breast cancers has been explored and confirmed. However, the relationship between GATA3 expression and different breast carcinoma intrinsic subtypes has not been specifically defined in the literature despite a few reports with a small number of cases. The aim of the current investigation is to clarify GATA3 expression among different histological subtypes and surrogate molecular breast carcinoma subtypes in a large series of cases...
April 20, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28394898/prognostic-and-clinicopathological-value-of-gata-binding-protein-3-in-breast-cancer-a-systematic-review-and-meta-analysis
#7
Yawen Guo, Pan Yu, Zeming Liu, Yusufu Maimaiti, Chen Chen, Yunke Zhang, Xingjie Yin, Shan Wang, Chunping Liu, Tao Huang
The potential prognostic value of GATA binding protein 3 (GATA3) in breast cancer has recently increased, although the evidence is inconclusive. This meta-analysis of 10 articles involving 5,080 breast cancer patients explored the prognostic and clinicopathological value of GATA3 in breast cancer. Time to tumor progression (TTP) and overall survival (OS) were primary endpoints. Pooled hazard ratio (HR), pooled risk ratio (RR), and 95% confidence interval (CI) were calculated to evaluate the association between GATA3, prognosis, and clinicopathological parameters...
2017: PloS One
https://www.readbyqxmd.com/read/28211079/gata3-expression-in-triple-negative-breast-cancers
#8
David J Byrne, Siddhartha Deb, Elena A Takano, Stephen B Fox
AIMS: GATA-binding protein 3 (GATA3) is a well-studied transcription factor found to be essential in the development of luminal breast epithelium and has been identified in a variety of tumour types, including breast and urothelial carcinomas, making it a useful immunohistochemistry marker in the diagnosis of both primary and metastatic disease. METHODS AND RESULTS: We investigated GATA3 protein expression in a 106 primary triple-negative breast carcinomas (100 basal-like, six non-basal-like) using Cell Marque mouse monoclonal anti-GATA3 (L50-823)...
February 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28122723/male-breast-cancer-a-single-institution-clinicopathologic-and-immunohistochemical-study
#9
Kate M Serdy, José Pablo Leone, David J Dabbs, Rohit Bhargava
OBJECTIVES: A clinicopathologic study with an emphasis on tumor immunohistochemical profile is presented. METHODS: Sixty-one cases of male invasive breast cancers were studied. Median age of the cohort was 65 years. RESULTS: Ninety-seven percent were estrogen receptor positive+ and 10% human epidermal growth factor receptor 2 positive. The individual diagnostic marker positivity was 98% for GATA-binding protein 3, 95% for androgen receptor, 90% for progesterone receptor, 88% for deleted in pancreatic cancer 4, 75% for gross cystic disease fluid protein 15, 72% for cytokeratin 7, 55% for mammaglobin, and 15% for vimentin and Wilms tumor protein 1...
January 24, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27867016/vasohibin-2-promotes-epithelial-mesenchymal-transition-in-human-breast-cancer-via-activation-of-transforming-growth-factor-%C3%AE-1-and-hypoxia-dependent-repression-of-gata-binding-factor-3
#10
Min Tu, Zhanjun Li, Xian Liu, Nan Lv, Chunhua Xi, Zipeng Lu, Jishu Wei, Guoxin Song, Jianmin Chen, Feng Guo, Kuirong Jiang, Shui Wang, Wentao Gao, Yi Miao
Vasohibin 2 (VASH2) is identified as an angiogenic factor, and has been implicated in tumor angiogenesis, proliferation and epithelial-mesenchymal transition (EMT). To investigate the EMT role of VASH2 in breast cancer, we overexpressed or knocked down expression of VASH2 in human breast cancer cell lines. We observed that VASH2 induced EMT in vitro and in vivo. The transforming growth factor β1 (TGFβ1) pathway was activated by VASH2, and expression of a dominant negative TGFβ type II receptor could block VASH2-mediated EMT...
March 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27721883/ductal-breast-carcinoma-metastatic-to-the-stomach-resembling-primary-linitis-plastica-in-a-male-patient
#11
Biagio Ricciuti, Giulia Costanza Leonardi, Noemi Ravaioli, Andrea De Giglio, Marta Brambilla, Enrico Prosperi, Franca Ribacchi, Marialuisa Meacci, Lucio Crinò, Daniele Maiettini, Rita Chiari, Giulio Metro
Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27338760/utility-of-gata-3-in-the-work-up-of-breast-adenocarcinoma-and-its-differential-diagnosis-in-serous-effusions-a-cell-block-microarray-study
#12
Mohamed I El Hag, Jennifer Ha, Rosemary Farag, Amani M El Hag, Claire W Michael
BACKGROUND: GATA-3 is a transcription factor involved in human tissue growth and differentiation. It is a potential marker for breast carcinoma origin in metastasis and predictive of good prognosis. We aim to evaluate the role of GATA3 in determining the breast origin of metastatic adenocarcinoma in malignant effusions using immunohistochemistry on cell-block microarray in comparison with ER and PR results. METHODS: Cell blocks from 100 cases of malignant and reactive serous effusions with confirmed diagnosis were selected; 28 mammary carcinomas, 64 extra-mammary adenocarcinomas (gastrointestinal, pulmonary, gynecologic), and 8 reactive mesothelium proliferation as control...
September 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27313731/metastasis-of-ovarian-cancer-to-the-breast-a-report-of-two-cases-and-a-review-of-the-literature
#13
Clemens B Tempfer, Nariman El Fizazi, Hassan Ergonenc, Wiebke Solass
Metastasis of ovarian cancer to the breast (MOCB) is a rare event. Clinical presentations of MOCB vary and surgery is the mainstay of treatment. The current study presents two cases of MOCB in women with recurrent ovarian cancer first diagnosed in April 2011 and October 2013, respectively. The patients presented to the clinic with a localized, palpable, painful mass in the upper outer quadrant of the right breast and a centrally localized, palpable, painful mass of the left breast, respectively. Breast sonography and mammography showed a singular, round, homogenous tumor with irregular borders in each case...
June 2016: Oncology Letters
https://www.readbyqxmd.com/read/27067807/gata-3-expression-is-not-associated-with-complete-pathological-response-in-triple-negative-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#14
Jason K Wasserman, Phillip A Williams, Shahidul Islam, Susan J Robertson
OBJECTIVE: The prognosis for patients with triple negative breast cancer (TNBC) is poor, however, a subset will demonstrate complete pathological response (pCR) to chemotherapy. GATA-3 and AR may be a negative predictors for pCR although it is unclear if these results apply to TNBC. METHODS: Patients diagnosed with TNBC and treated with neoadjuvant chemotherapy were identified. Immunohistochemistry was performed for GATA-3 and AR. Both were scored using a composite of staining intensity and percentage cells stained...
June 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27041579/foxc1-is-involved-in-er%C3%AE-silencing-by-counteracting-gata3-binding-and-is-implicated-in-endocrine-resistance
#15
Y Yu-Rice, Y Jin, B Han, Y Qu, J Johnson, T Watanabe, L Cheng, N Deng, H Tanaka, B Gao, Z Liu, Z Sun, S Bose, A E Giuliano, X Cui
Estrogen receptor-α (ERα) mediates the essential biological function of estrogen in breast development and tumorigenesis. Multiple mechanisms, including pioneer factors, coregulators and epigenetic modifications have been identified as regulators of ERα signaling in breast cancer. However, previous studies of ERα regulation have focused on luminal and HER2-positive subtypes rather than basal-like breast cancer (BLBC), in which ERα is underexpressed. In addition, mechanisms that account for the decrease or loss of ER expression in recurrent tumors after endocrine therapy remain elusive...
October 13, 2016: Oncogene
https://www.readbyqxmd.com/read/27036044/dysregulation-of-junctional-adhesion-molecule-a-via-p63-gata-3-in-head-and-neck-squamous-cell-carcinoma
#16
Takuya Kakuki, Makoto Kurose, Ken-Ichi Takano, Atsushi Kondoh, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Yakuto Kaneko, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Takayuki Kohno, Tetsuo Himi, Takashi Kojima
Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is a tight junction molecule associated with epithelial and endothelial barrier function. Overexpression of JAM-A is also closely associated with invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer. However, little is known about the mechanism in overexpression of JAM-A in head and neck squamous cell carcinoma (HNSCC). In the present study, we found high expression of JAM-A at the protein and mRNA levels in HNSCC tissues, including those of the oropharynx, larynx, and hypopharynx, together with high protein expression of β-catenin, p63, ΔNp63 and GATA-3...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27006379/effects-of-pubertal-exposure-to-dietary-soy-on-estrogen-receptor-activity-in-the-breast-of-cynomolgus-macaques
#17
Fitriya N Dewi, Charles E Wood, Cynthia J Willson, Thomas C Register, Cynthia J Lees, Timothy D Howard, Zhiqing Huang, Susan K Murphy, Janet A Tooze, Jeff W Chou, Lance D Miller, J Mark Cline
Endogenous estrogens influence mammary gland development during puberty and breast cancer risk during adulthood. Early-life exposure to dietary or environmental estrogens may alter estrogen-mediated processes. Soy foods contain phytoestrogenic isoflavones (IF), which have mixed estrogen agonist/antagonist properties. Here, we evaluated mammary gland responses over time in pubertal female cynomolgus macaques fed diets containing either casein/lactalbumin (n = 12) or soy protein containing a human-equivalent dose of 120 mg IF/day (n = 17) for approximately 4...
May 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/26998104/s100a8-a9-is-associated-with-estrogen-receptor-loss-in-breast-cancer
#18
Y I Bao, Antao Wang, Juanfen Mo
S100A8 and S100A9 are calcium-binding proteins that are secreted primarily by granulocytes and monocytes, and are upregulated during the inflammatory response. S100A8 and S100A9 have been identified to be expressed by epithelial cells involved in malignancy. In the present study, the transcriptional levels of S100A8 and S100A9 were investigated in various subtypes of breast cancer (BC), and the correlation with estrogen receptor 1 (ESR1) and GATA binding protein 3 (GATA3) gene expression was evaluated using microarray datasets...
March 2016: Oncology Letters
https://www.readbyqxmd.com/read/26968831/selective-isolation-and-characterization-of-primary-cells-from-normal-breast-and-tumors-reveal-plasticity-of-adipose-derived-stem-cells
#19
Annika Weigand, Anja M Boos, Kereshmeh Tasbihi, Justus P Beier, Paul D Dalton, Michael Schrauder, Raymund E Horch, Matthias W Beckmann, Pamela L Strissel, Reiner Strick
BACKGROUND: There is a need to establish more cell lines from breast tumors in contrast to immortalized cell lines from metastatic effusions in order to represent the primary tumor and not principally metastatic biology of breast cancer. This investigation describes the simultaneous isolation, characterization, growth and function of primary mammary epithelial cells (MEC), mesenchymal cells (MES) and adipose derived stem cells (ADSC) from four normal breasts, one inflammatory and one triple-negative ductal breast tumors...
March 12, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/26852374/characterization-of-mammary-adenocarcinomas-in-male-rats-after-n-methyl-n-nitrosourea-exposure-potential-for-human-male-breast-cancer-model
#20
Katsuhiko Yoshizawa, Michiko Yuki, Yuichi Kinoshita, Yuko Emoto, Takashi Yuri, Nobuaki Shikata, Susan A Elmore, Airo Tsubura
The frequency of breast cancer in men is extremely rare, reported to be less than 1% and there is currently no available animal model for male mammary tumors. We compared the characteristics of various immunohistochemical markers in N-methyl-N-nitrosourea (MNU)-induced mammary adenocarcinomas in male and female Crj:CD(SD)IGS rats including: estrogen receptor α (ER), progesterone receptor (PgR), androgen receptor (AR), receptor tyrosine-protein kinase erbB-2 (HER2), GATA binding protein 3 (GATA3), and proliferating cell nuclear antigen (PCNA)...
May 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
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