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Gata 3 breast cancer

Biagio Ricciuti, Giulia Costanza Leonardi, Noemi Ravaioli, Andrea De Giglio, Marta Brambilla, Enrico Prosperi, Franca Ribacchi, Marialuisa Meacci, Lucio Crinò, Daniele Maiettini, Rita Chiari, Giulio Metro
Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation...
September 2016: Journal of Breast Cancer
Mohamed I El Hag, Jennifer Ha, Rosemary Farag, Amani M El Hag, Claire W Michael
BACKGROUND: GATA-3 is a transcription factor involved in human tissue growth and differentiation. It is a potential marker for breast carcinoma origin in metastasis and predictive of good prognosis. We aim to evaluate the role of GATA3 in determining the breast origin of metastatic adenocarcinoma in malignant effusions using immunohistochemistry on cell-block microarray in comparison with ER and PR results. METHODS: Cell blocks from 100 cases of malignant and reactive serous effusions with confirmed diagnosis were selected; 28 mammary carcinomas, 64 extra-mammary adenocarcinomas (gastrointestinal, pulmonary, gynecologic), and 8 reactive mesothelium proliferation as control...
September 2016: Diagnostic Cytopathology
Clemens B Tempfer, Nariman El Fizazi, Hassan Ergonenc, Wiebke Solass
Metastasis of ovarian cancer to the breast (MOCB) is a rare event. Clinical presentations of MOCB vary and surgery is the mainstay of treatment. The current study presents two cases of MOCB in women with recurrent ovarian cancer first diagnosed in April 2011 and October 2013, respectively. The patients presented to the clinic with a localized, palpable, painful mass in the upper outer quadrant of the right breast and a centrally localized, palpable, painful mass of the left breast, respectively. Breast sonography and mammography showed a singular, round, homogenous tumor with irregular borders in each case...
June 2016: Oncology Letters
Jason K Wasserman, Phillip A Williams, Shahidul Islam, Susan J Robertson
OBJECTIVE: The prognosis for patients with triple negative breast cancer (TNBC) is poor, however, a subset will demonstrate complete pathological response (pCR) to chemotherapy. GATA-3 and AR may be a negative predictors for pCR although it is unclear if these results apply to TNBC. METHODS: Patients diagnosed with TNBC and treated with neoadjuvant chemotherapy were identified. Immunohistochemistry was performed for GATA-3 and AR. Both were scored using a composite of staining intensity and percentage cells stained...
June 2016: Pathology, Research and Practice
Y Yu-Rice, Y Jin, B Han, Y Qu, J Johnson, T Watanabe, L Cheng, N Deng, H Tanaka, B Gao, Z Liu, Z Sun, S Bose, A E Giuliano, X Cui
Estrogen receptor-α (ERα) mediates the essential biological function of estrogen in breast development and tumorigenesis. Multiple mechanisms, including pioneer factors, coregulators and epigenetic modifications have been identified as regulators of ERα signaling in breast cancer. However, previous studies of ERα regulation have focused on luminal and HER2-positive subtypes rather than basal-like breast cancer (BLBC), in which ERα is underexpressed. In addition, mechanisms that account for the decrease or loss of ER expression in recurrent tumors after endocrine therapy remain elusive...
April 4, 2016: Oncogene
Takuya Kakuki, Makoto Kurose, Ken-Ichi Takano, Atsushi Kondoh, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Yakuto Kaneko, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Takayuki Kohno, Tetsuo Himi, Takashi Kojima
Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is a tight junction molecule associated with epithelial and endothelial barrier function. Overexpression of JAM-A is also closely associated with invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer. However, little is known about the mechanism in overexpression of JAM-A in head and neck squamous cell carcinoma (HNSCC). In the present study, we found high expression of JAM-A at the protein and mRNA levels in HNSCC tissues, including those of the oropharynx, larynx, and hypopharynx, together with high protein expression of β-catenin, p63, ΔNp63 and GATA-3...
June 7, 2016: Oncotarget
Fitriya N Dewi, Charles E Wood, Cynthia J Willson, Thomas C Register, Cynthia J Lees, Timothy D Howard, Zhiqing Huang, Susan K Murphy, Janet A Tooze, Jeff W Chou, Lance D Miller, J Mark Cline
Endogenous estrogens influence mammary gland development during puberty and breast cancer risk during adulthood. Early-life exposure to dietary or environmental estrogens may alter estrogen-mediated processes. Soy foods contain phytoestrogenic isoflavones (IF), which have mixed estrogen agonist/antagonist properties. Here, we evaluated mammary gland responses over time in pubertal female cynomolgus macaques fed diets containing either casein/lactalbumin (n = 12) or soy protein containing a human-equivalent dose of 120 mg IF/day (n = 17) for approximately 4...
May 2016: Cancer Prevention Research
Y I Bao, Antao Wang, Juanfen Mo
S100A8 and S100A9 are calcium-binding proteins that are secreted primarily by granulocytes and monocytes, and are upregulated during the inflammatory response. S100A8 and S100A9 have been identified to be expressed by epithelial cells involved in malignancy. In the present study, the transcriptional levels of S100A8 and S100A9 were investigated in various subtypes of breast cancer (BC), and the correlation with estrogen receptor 1 (ESR1) and GATA binding protein 3 (GATA3) gene expression was evaluated using microarray datasets...
March 2016: Oncology Letters
Annika Weigand, Anja M Boos, Kereshmeh Tasbihi, Justus P Beier, Paul D Dalton, Michael Schrauder, Raymund E Horch, Matthias W Beckmann, Pamela L Strissel, Reiner Strick
BACKGROUND: There is a need to establish more cell lines from breast tumors in contrast to immortalized cell lines from metastatic effusions in order to represent the primary tumor and not principally metastatic biology of breast cancer. This investigation describes the simultaneous isolation, characterization, growth and function of primary mammary epithelial cells (MEC), mesenchymal cells (MES) and adipose derived stem cells (ADSC) from four normal breasts, one inflammatory and one triple-negative ductal breast tumors...
2016: Breast Cancer Research: BCR
Katsuhiko Yoshizawa, Michiko Yuki, Yuichi Kinoshita, Yuko Emoto, Takashi Yuri, Nobuaki Shikata, Susan A Elmore, Airo Tsubura
The frequency of breast cancer in men is extremely rare, reported to be less than 1% and there is currently no available animal model for male mammary tumors. We compared the characteristics of various immunohistochemical markers in N-methyl-N-nitrosourea (MNU)-induced mammary adenocarcinomas in male and female Crj:CD(SD)IGS rats including: estrogen receptor α (ER), progesterone receptor (PgR), androgen receptor (AR), receptor tyrosine-protein kinase erbB-2 (HER2), GATA binding protein 3 (GATA3), and proliferating cell nuclear antigen (PCNA)...
May 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
Taisia Vitkovski, Shweta Chaudhary, Cristina Sison, Mansoor Nasim, Michael John Esposito, Tawfiqul Bhuiya
An incidental finding of napsin A-positive breast carcinoma with apocrine features during workup for metastatic cancer in an axillary lymph node led to our investigation of the incidence of napsin A expression in breast carcinomas, focusing on those with apocrine features. We included 97 cases of breast carcinomas and performed immunohistochemistry with napsin A, GATA-3, thyroid transcription factor-1, and GCDFP-15. There was a statistically significant difference between apocrine and nonapocrine cases with respect to polyclonal napsin A H-scores (P < ...
August 2016: International Journal of Surgical Pathology
Soyoung Kim, So-Young Chun, Yun-Suk Kwon, Kyung-Soo Nam
Although many studies have implicated the crosstalk between the Wnt and PKC signaling pathways in tumor initiation and progression, the molecular roles of PKC isoforms in the Wnt signaling pathway remain poorly understood. In this study, we explored the contribution of PKC isoforms to canonical and noncanonical Wnt signaling pathway in mediating cell migration and an epithelial-mesenchymal transition (EMT). When MCF-7 cells were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) for up to 3 weeks, the effect of TPA on Wnt signaling pathway was dramatically different depending on the exposure time...
February 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jashodeep Datta, Megan Fracol, Matthew T McMillan, Erik Berk, Shuwen Xu, Noah Goodman, David A Lewis, Angela DeMichele, Brian J Czerniecki
IMPORTANCE: There is a paucity of immune signatures identifying patients with human epidermal growth factor receptor 2 (HER2)-positive invasive breast cancer (IBC) at risk for treatment failure following trastuzumab and chemotherapy. OBJECTIVE: To determine whether circulating anti-HER2 CD4-positive (CD4+) T-helper type 1 (Th1) immunity correlates with recurrence in patients with completely treated HER2-positive IBC. DESIGN, SETTING, AND PARTICIPANTS: Hypothesis-generating exploratory translational analysis at a tertiary care referral center of patients with completely treated HER2-positive IBC with median (interquartile range) follow-up of 44 (31) months...
February 2016: JAMA Oncology
Drew G Davis, Momin T Siddiqui, Gabriela Oprea-Ilies, Keith Stevens, Adeboye O Osunkoya, Cynthia Cohen, Xiaoxian Bill Li
GATA-3, a member of the GATA family of zinc-finger DNA binding proteins, and FOXA1, a member of the forkhead transcription factor family, are both associated with estrogen receptor expression. Both GATA-3 and FOXA1 are useful markers for breast carcinoma, but their expression in the different breast cancer subtypes and other neoplasms has not been thoroughly evaluated. We examined the expression of GATA-3 and FOXA1 in estrogen receptor-positive, Her2/neu-positive, and triple-negative breast carcinomas as well as in 10 other common carcinomas, including hepatocellular, colonic, pancreatic, gastric, endometrial (endometrioid), lung, prostatic, renal cell, urothelial, and ovarian serous carcinomas...
January 2016: Human Pathology
Madelyn Lew, Judy C Pang, Xin Jing, Kristina L Fields, Michael H Roh
BACKGROUND: It is not uncommon to encounter challenges in the immunohistochemical confirmation of metastatic breast cancer given the limited sensitivities of mammaglobin and gross cystic disease fluid protein 15 (GCDFP-15/BRST-2) and the significant proportion of triple-negative breast carcinomas (ie, tumors that are negative for estrogen receptor [ER], and progesterone receptor [PgR], and human epidermal growth factor 2 [HER2]). GATA binding protein 3 (GATA3) has emerged as a potentially useful immunohistochemical adjunct during the evaluation of metastatic breast carcinomas in cytology specimens...
October 2015: Cancer Cytopathology
Daniel N Dang, Ganesh Raj, Venetia Sarode, Kyle H Molberg, Ratna K Vadlamudi, Yan Peng
PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expression by immunohistochemistry in primary and metastatic triple-negative tumors in human tissues and compared its expression with GATA-binding protein 3 (GATA3), a novel diagnostic marker for TNBC...
December 2015: Human Pathology
Doreen N Nguyen, Satomi Kawamoto, Ashley Cimino-Mathews, Peter B Illei, Dorothy L Rosenthal, Christopher J VandenBussche
Metaplastic squamous cell carcinoma (SCC) of the breast is a rare type of breast cancer. Metastases to the lung, which can be a major site of second primary tumor development among breast cancer patients, are difficult to distinguish from primary SCC of the lung and present a unique challenge for pathologists. There are few available discriminating immunohistochemical markers as squamous differentiation typically leads to loss of expression of characteristic primary epithelial cell markers of both breast and lung origin...
October 2015: Diagnostic Cytopathology
Yu Wei Phua, Akira Nguyen, Daniel L Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea Mcfarland, Roslin Russell, Warren Kaplan, Mark J Cowley, Radhika Nair, Elena Zotenko, Sandra O'Toole, Shi-Xiong Tan, David E James, Susan J Clark, Hosein Kouros-Mehr, Alexander Swarbrick
INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary developmental and carcinogenesis. In recent years an important role for microRNAs (miRNAs) in a myriad of cellular processes in development and in oncogenesis has emerged. METHODS: microRNA profiling was conducted on stromal and epithelial cellular subsets microdissected from the pubertal mouse mammary gland...
2015: Breast Cancer Research: BCR
Jashodeep Datta, Erik Berk, Shuwen Xu, Elizabeth Fitzpatrick, Cinthia Rosemblit, Lea Lowenfeld, Noah Goodman, David A Lewis, Paul J Zhang, Carla Fisher, Robert E Roses, Angela DeMichele, Brian J Czerniecki
INTRODUCTION: A progressive loss of circulating anti-human epidermal growth factor receptor-2/neu (HER2) CD4(+) T-helper type 1 (Th1) immune responses is observed in HER2(pos)-invasive breast cancer (IBC) patients relative to healthy controls. Pathologic complete response (pCR) following neoadjuvant trastuzumab and chemotherapy (T + C) is associated with decreased recurrence and improved prognosis. We examined differences in anti-HER2 Th1 responses between pCR and non-pCR patients to identify modifiable immune correlates to pathologic response following neoadjuvant T + C...
2015: Breast Cancer Research: BCR
Nick Orr, Frank Dudbridge, Nicola Dryden, Sarah Maguire, Daniela Novo, Eleni Perrakis, Nichola Johnson, Maya Ghoussaini, John L Hopper, Melissa C Southey, Carmel Apicella, Jennifer Stone, Marjanka K Schmidt, Annegien Broeks, Laura J Van't Veer, Frans B Hogervorst, Peter A Fasching, Lothar Haeberle, Arif B Ekici, Matthias W Beckmann, Lorna Gibson, Zoe Aitken, Helen Warren, Elinor Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Barbara Burwinkel, Frederik Marme, Andreas Schneeweiss, Chistof Sohn, Pascal Guénel, Thérèse Truong, Emilie Cordina-Duverger, Marie Sanchez, Stig E Bojesen, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Javier Benitez, Maria Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Hoda Anton-Culver, Susan L Neuhausen, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Ute Hamann, Hiltrud Brauch, Christina Justenhoven, Thomas Brüning, Yon-Dschun Ko, Heli Nevanlinna, Kristiina Aittomäki, Carl Blomqvist, Sofia Khan, Natalia Bogdanova, Thilo Dörk, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Georgia Chenevix-Trench, Jonathan Beesley, Diether Lambrechts, Matthieu Moisse, Guiseppe Floris, Benoit Beuselinck, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Paolo Radice, Paolo Peterlongo, Bernard Peissel, Valeria Pensotti, Fergus J Couch, Janet E Olson, Seth Slettedahl, Celine Vachon, Graham G Giles, Roger L Milne, Catriona McLean, Christopher A Haiman, Brian E Henderson, Fredrick Schumacher, Loic Le Marchand, Jacques Simard, Mark S Goldberg, France Labrèche, Martine Dumont, Vessela Kristensen, Grethe Grenaker Alnæs, Silje Nord, Anne-Lise Borresen-Dale, Wei Zheng, Sandra Deming-Halverson, Martha Shrubsole, Jirong Long, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Irene L Andrulis, Julia A Knight, Gord Glendon, Sandrine Tchatchou, Peter Devilee, Robertus A E M Tollenaar, Caroline M Seynaeve, Christi J Van Asperen, Montserrat Garcia-Closas, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Kamila Czene, Hatef Darabi, Mikael Eriksson, Daniel Klevebring, Maartje J Hooning, Antoinette Hollestelle, Carolien H M van Deurzen, Mieke Kriege, Per Hall, Jingmei Li, Jianjun Liu, Keith Humphreys, Angela Cox, Simon S Cross, Malcolm W R Reed, Paul D P Pharoah, Alison M Dunning, Mitul Shah, Barbara J Perkins, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Alan Ashworth, Anthony Swerdlow, Michael Jones, Minouk J Schoemaker, Alfons Meindl, Rita K Schmutzler, Curtis Olswold, Susan Slager, Amanda E Toland, Drakoulis Yannoukakos, Kenneth Muir, Artitaya Lophatananon, Sarah Stewart-Brown, Pornthep Siriwanarangsan, Keitaro Matsuo, Hidema Ito, Hiroji Iwata, Junko Ishiguro, Anna H Wu, Chiu-Chen Tseng, David Van Den Berg, Daniel O Stram, Soo Hwang Teo, Cheng Har Yip, Peter Kang, Mohammad Kamran Ikram, Xiao-Ou Shu, Wei Lu, Yu-Tang Gao, Hui Cai, Daehee Kang, Ji-Yeob Choi, Sue K Park, Dong-Young Noh, Mikael Hartman, Hui Miao, Wei Yen Lim, Soo Chin Lee, Suleeporn Sangrajrang, Valerie Gaborieau, Paul Brennan, James Mckay, Pei-Ei Wu, Ming-Feng Hou, Jyh-Cherng Yu, Chen-Yang Shen, William Blot, Qiuyin Cai, Lisa B Signorello, Craig Luccarini, Caroline Bayes, Shahana Ahmed, Mel Maranian, Catherine S Healey, Anna González-Neira, Guillermo Pita, M Rosario Alonso, Nuria Álvarez, Daniel Herrero, Daniel C Tessier, Daniel Vincent, Francois Bacot, David J Hunter, Sara Lindstrom, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Douglas F Easton, Isabel dos Santos Silva, Olivia Fletcher, Julian Peto
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52 studies and a further 5795 cases and 6624 controls of Asian ancestry from nine studies. Single nucleotide polymorphism (SNP) rs676256 was most strongly associated with risk in Europeans (odds ratios [OR] = 0.90 [0.88-0.92]; P-value = 1...
May 15, 2015: Human Molecular Genetics
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