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JOURNAL ARTICLE
Rituraj Mishra, Jonathan R J Yong, Corentin Jacquemmoz, Benjamin Lorandel, Mohammadali Foroozandeh, Jean-Nicolas Dumez
Spatially-encoded diffusion-ordered NMR spectroscopy (SPEN-DOSY) has emerged as a new time-efficient tool for the analysis of mixtures of small molecules in solution. Time efficiency is achieved using the concept of spatial parallelization of the effective gradient area, instead of the sequential incrementation used in conventional diffusion experiments. The data acquired with such sequences are then usually processed to extract diffusion coefficients, but cases when peak overlap in the 1 H spectrum are difficult to address...
January 22, 2024: Journal of Magnetic Resonance
#22
JOURNAL ARTICLE
Agostina Spadea, Maria Oleiro Hidalgo, Sofía Quevedo, Carolina Begue, Gabriela L'Arco, Adriana Pérez, Gerardo Cueto, Jonatan Konfino
INTRODUCCIÓN: la pandemia de la COVID-19 ha acentuado las desigualdades sociales, económicas y relacionadas con la salud, afectando desproporcionadamente a las personas en situación de vulnerabilidad y perpetuando la inequidad en salud. En Argentina se implementó una campaña nacional gratuita de vacunación contra la COVID-19 con una perspectiva de equidad. OBJETIVO: identificar desigualdades territoriales en el acceso a la vacunación contra la COVID-19 en Quilmes...
January 31, 2024: Global Health Promotion
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JOURNAL ARTICLE
Bianca Buchignani, Gianpaolo Cicala, Francesca Cumbo, Martina Ricci, Anna Capasso, Chiara Ticci, Sara Mazzanti, Noemi Brolatti, Michele Tosi, Claudia Dosi, Laura Antonaci, Giorgia Coratti, Maria Carmela Pera, Daniela Leone, Concetta Palermo, Beatrice Berti, Anna Lia Frongia, Michele Sacchini, Claudio Bruno, Riccardo Masson, Adele D'Amico, Roberta Battini, Marika Pane, Eugenio Mercuri
OBJECTIVE: The aim of this study was to assess early language acquisitions in treated individuals with spinal muscular atrophy (SMA) type 1 and in infants identified by newborn screening (NBS). METHODS: Parents of SMA individuals aged between 8 and 36 months were asked to fill in the MacArthur-Bates Communicative Development Inventory (MB-CDI) that assesses comprehension, gesture and expressive skills. A follow-up assessment was performed in 21 of the 36. RESULTS: The MB-CDI was completed by parents of 24 type 1 and 12 infants identified by NBS...
January 30, 2024: Archives of Disease in Childhood
#24
JOURNAL ARTICLE
Owen Tooley, William Pointer, Rowan Radmall, Mia Hall, Valentin Beyer, Kieran Stakem, Thomas Swift, James Town, Tanja Junkers, Paul Wilson, Daniel Lester, David Haddleton
Measurement of molecular weight is an integral part of macromolecular and polymer characterization which usually has limitations. Herein, we present the use of a bench-top 80 MHz NMR spectrometer for diffusion-ordered spectroscopy as a practical and rapid approach for the determination of molecular weight/size using a novel solvent and polymer-independent universal calibration. This article is protected by copyright. All rights reserved.
January 30, 2024: Macromolecular Rapid Communications
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REVIEW
Trần Thanh Tâm Phạm, Alexandre Murza, Éric Marsault, John P Frampton, Jan K Rainey
The apelinergic system encompasses two peptide ligand families, apelin and apela, along with the apelin receptor (AR or APJ), a class A G-protein-coupled receptor. This system has diverse physiological effects, including modulating heart contraction, vasodilation/constriction, glucose regulation, and vascular development, with involvement in a variety of pathological conditions. Apelin peptides have been previously shown to interact with and become structured upon binding to anionic micelles, consistent with a membrane-catalyzed mechanism of ligand-receptor binding...
January 24, 2024: Biochimica et Biophysica Acta. Biomembranes
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JOURNAL ARTICLE
Yen Vo, Mitchell D Nothling, Radhika Raveendran, Cheng Cao, Martina H Stenzel
The field of single-chain nanoparticles (SCNPs) continues to mature, and an increasing range of reports have emerged that explore the application of these small nanoparticles. A key application for SCNPs is in the field of drug delivery, and recent work suggests that SCNPs can be readily internalized by cells. However, limited attention has been directed to the delivery of small-molecule drugs using SCNPs. Moreover, studies on the physicochemical effects of drug loading on SCNP performance is so far missing, despite the accepted view that such small nanoparticles should be significantly affected by the drug loading content...
January 24, 2024: Biomacromolecules
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REVIEW
Aron Syversen, Alexios Dosis, David Jayne, Zhiqiang Zhang
Surgery is a common first-line treatment for many types of disease, including cancer. Mortality rates after general elective surgery have seen significant decreases whilst postoperative complications remain a frequent occurrence. Preoperative assessment tools are used to support patient risk stratification but do not always provide a precise and accessible assessment. Wearable sensors (WS) provide an accessible alternative that offers continuous monitoring in a non-clinical setting. They have shown consistent uptake across the perioperative period but there has been no review of WS as a preoperative assessment tool...
January 12, 2024: Sensors
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JOURNAL ARTICLE
Evan R McCarney, Kenneth A Kristoffersen, Kathryn E Anderssen
Benchtop diffusion nuclear magnetic resonance (NMR) spectroscopy was used to perform quantitative monitoring of enzymatic hydrolysis. The study aimed to test the feasibility of the technology to characterize enzymatic hydrolysis processes in real time. Diffusion ordered spectroscopy (DOSY) was used to measure the signal intensity and apparent self-diffusion constant of solubilized protein in hydrolysate. The NMR technique was tested on an enzymatic hydrolysis reaction of red cod, a lean white fish, by the endopeptidase alcalase at 50°C...
January 18, 2024: Magnetic Resonance in Chemistry: MRC
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JOURNAL ARTICLE
María Angiono, María Mesa Y Morteo, María Oshiro, Mariela Philippin, Janisse Requena Olavarría, Verónica Sánchez, Daniel H Pryluka
OBJETIVO: La pandemia por COVID-19 dejó a los trabajadores de salud agotados física y mentalmente. Estudios demostraron el incremento de patologías psicológicas y psiquiátricas con la pandemia. En este trabajo se midió el impacto de la vacunación contra COVID-19 en las manifestaciones emocionales y síntomas psicológicos de los trabajadores de un hospital general de agudos de la Ciudad de Buenos Aires, Argentina Método: Se desarrolló este estudio descriptivo, observacional, transversal y analítico...
January 10, 2024: Vertex: Revista Argentina de Psiquiatriá
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JOURNAL ARTICLE
Eleanor M Hilton, Michael A Jinks, Andrew D Burnett, Nicholas J Warren, Andrew John Wilson
Supramolecular polymers offer tremendous potential to produce new "smart" materials however, there remains a need to develop systems that are responsive to external stimuli. In this work visible-light responsive hydrogen-bonded supramolecular polymers comprising photoresponsive supramolecular synthons (I-III) consisting of two hydrogen bonding motifs (HBMs) connected by a central ortho-tetrafluorinated azobenzene have been characterized by DOSY NMR and viscometry. Comparison of different hydrogen-bonding motifs reveals that assembly in the low and high concentration regimes is strongly influenced by the strength of association between the HBMs...
January 8, 2024: Chemistry: a European Journal
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JOURNAL ARTICLE
Michael Koch, Vanessa Fauck, Matti Sievert, Konstantinos Mantsopoulos, Heinrich Iro, Sarina Mueller
PURPOSE: To assess ultrasound (US) features observed in salivary glands after radioactive iodine treatment (RAIT) in relation to the dose and time interval after RAIT. MATERIALS AND METHODS: A retrospective analysis of US findings regarding the salivary glands of patients presenting after RAIT due to thyroid cancer (Group 1, n=99) or benign thyroid diseases (Group 2, n=25). The control group consisted of randomly selected patients (no RAIT, Group 3, n=100). Groups were compared regarding RAIT dose, symptoms, and US findings (duct dilation, hypoechoic/heterogeneous parenchyma, parenchymal loss)...
January 3, 2024: Ultraschall in der Medizin
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JOURNAL ARTICLE
Rodrigo Bremer Nones, Eron Fabio Miranda, Gustavo de Nardi Marçal, Fernanda da Silva Barbosa Baraúna, Marcela Rocha Loures, Paula Cenira Senger, Daniela de Oliveira Magro, Paulo Gustavo Kotze
OBJECTIVES: In Latin America, experience with monitoring serum Infliximab (IFX) concentrations is scarce. Our study aimed to compare IFX serum concentrations between patients with active disease or in remission. PATIENTS AND METHODS: A cross-sectional study was performed in patients with luminal Crohn's disease (CD) during maintenance treatment with IFX. Patients were classified as in remission or disease activity according to clinical scores and endoscopic, radiological, and laboratory markers...
December 29, 2023: Gastroenterología y Hepatología
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JOURNAL ARTICLE
Giorgia Coratti, Marika Pane, Claudia Brogna, Adele D'Amico, Elena Pegoraro, Luca Bello, Valeria A Sansone, Emilio Albamonte, Elisabetta Ferraroli, Elena Stacy Mazzone, Lavinia Fanelli, Sonia Messina, Maria Sframeli, Michela Catteruccia, Gianpaolo Cicala, Anna Capasso, Martina Ricci, Silvia Frosini, Giacomo De Luca, Enrica Rolle, Roberto De Sanctis, Nicola Forcina, Giulia Norcia, Luigia Passamano, Marianna Scutifero, Alice Gardani, Antonella Pini, Giulia Monaco, Maria Grazia D'Angelo, Daniela Leone, Riccardo Zanin, Gian Luca Vita, Chiara Panicucci, Claudio Bruno, Tiziana Mongini, Federica Ricci, Angela Berardinelli, Roberta Battini, Riccardo Masson, Giovanni Baranello, Claudia Dosi, Enrico Bertini, Vincenzo Nigro, Luisa Politano, Eugenio Mercuri
Duchenne muscular dystrophy (DMD) is a neuromuscular condition characterized by muscle weakness. The Performance of upper limb (PUL) test is designed to evaluate upper limb function in DMD patients across three domains. The aim of this study is to identify frequently lost or gained PUL 2.0 abilities at distinct functional stages in DMD patients. This retrospective study analyzed prospectively collected data on 24-month PUL 2.0 changes related to ambulatory function. Ambulant patients were categorized based on initial 6MWT distance, non-ambulant patients by time since ambulation loss...
December 3, 2023: Neuromuscular Disorders: NMD
#34
REVIEW
Donato D'Angelo, Denis Vecellio Reane, Anna Raffaello
Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial Ca2+ (mitCa2+ ) is a key regulator of oxidative metabolism and cell death. MitCa2+ uptake is mediated by the mitochondrial Ca2+ uniporter complex (MCUc) localized in the inner mitochondrial membrane (IMM). MitCa2+ uptake stimulates the activity of three key enzymes of the Krebs cycle, thereby modulating ATP production and promoting oxidative metabolism...
2023: Frontiers in Molecular Biosciences
#35
JOURNAL ARTICLE
Soumaya Khlifi, Sa Yao, Clément Falaise, Pierre Bauduin, Vincent Guérineau, Nathalie Leclerc, Mohamed Haouas, Hanene Salmi-Mani, Philippe Roger, Emmanuel Cadot
Supramolecular polymers built from stimuli-responsive host-guest interactions represent an attractive way of tailoring smart materials. Herein, we exploit the chaotropic effect of polyoxometalates and related host-guest properties to design unconventional polymer systems with reversible redox and thermo-responsive sol-gel transition. These supramolecular networks result from the association of cyclodextrin-based oligomers and Keggin-type POMs acting as electro-active crosslinking agents. The structure and the dynamics of such self-assembly systems have been investigated using a multiscale approach involving MALDI-TOF, viscosity measurements, cyclic voltammetry, 1H-NMR (1D and DOSY), and Small-Angle X-ray Scattering...
December 26, 2023: Chemistry: a European Journal
#36
JOURNAL ARTICLE
Andrea Pietravalle, Alessia Dosi, Telmo Ambrosio Inocêncio, Francesco Cavallin, Joaquim Tomás, Giovanni Putoto, Nicola Laforgia
BACKGROUND: More than a quarter of children who are affected by severe acute undernutrition reside in Sub-Saharan Africa. Incorrect feeding practices have a negative impact on a child's health in both the short and the long term, and the interval from conception to two years is the most critical for the development of undernutrition-related complications. These first 1000 days of life also represent an "opportunity window" for early interventions, hence, having a clear insight into dietary habits and the determinants of diet quality is fundamental to improving nutritional counseling practices...
November 30, 2023: Children
#37
JOURNAL ARTICLE
Pibo Liu, Xiao Yang, He Li, Songbo Zhang, Yanming Hu, Guangyuan Zhou, Nikos Hadjichristidis
There are still challenges in the preparation of difunctional stereoregular polydienes, especially for the construction of initiating chain-end functionalization. Coordinative chain transfer polymerization (CCTP) provides a way to achieve the goal but usually requires sophisticated functionalized catalysts as well as expensive chain transfer agents (CTAs). In this work, heteroleptic aluminum with oligo(dienyl) substituents (oligo-Al agents) were readily prepared by living anionic polymerization (LAP) technique...
December 12, 2023: Angewandte Chemie
#38
JOURNAL ARTICLE
Aggeliki Dosi, Alexandra Meziti, Eleni Tounta, Kimon Koemtzopoulos, Anastasia Komnenou, Panagiotis Dendrinos, Konstantinos Kormas
This study showed that during the rehabilitation of two rescued Mediterranean monk seal pups ( Monachus monachus ), the skin and fecal bacterial communities showed similar succession patterns between the two individuals. This finding means that co-housed pups share their microbiomes, and this needs to be considered in cases of infection outbreaks and their treatment. The housing conditions, along with the feeding scheme and care protocols, including the admission of antibiotics as prophylaxis, probiotics, and essential food supplements, resulted in bacterial communities with no apparent pathogenic bacteria...
December 12, 2023: Microbiology Spectrum
#39
JOURNAL ARTICLE
Oliver P E Townrow, Christian Färber, Ulrich Zenneck, Sjoerd Harder
A hydrocarbon-soluble barium anthracene complex was prepared by means of metal vapour synthesis. Reaction of 9,10-bis(trimethylsilyl)anthracene (Anth'') with barium vapour gave deep purple Ba(Anth″) which after extraction with diethyl ether crystallised as the cyclic octamer [Ba(Anth'')·Et2O]8. Dissolution in benzene or toluene led to replacement of the Et2O ligand with a softer arene ligand and isolation of Ba(Anth'')·arene. DOSY-NMR measurements in benzene-d6 indicate solution species with a molecular weight that equals a trimeric constitution...
December 11, 2023: Angewandte Chemie
#40
JOURNAL ARTICLE
Norma Mongua-Rodríguez, Guadalupe Delgado-Sánchez, Elizabeth Ferreira-Guerrero, Leticia Ferreyra-Reyes, Maribel Martínez-Hernández, Sergio Canizales-Quintero, Norma Aracely Téllez-Vázquez, Lourdes García-García
OBJETIVO: Describir las coberturas de vacunación en 2022 en niñas, niños y en adolescentes, así como comparar las prevalencias observadas con los datos de la Encuesta Nacional de Salud y Nutrición 2021 (Ensanut 2021). Material y métodos. Análisis de datos obtenidos de la Ensanut 2022. RESULTADOS: En los niños menores de cinco años, las coberturas de vacuna con Bacilo de Calmette y Guérin (BCG), hepatitis B, pentavalente o hexavalente, neumocócica, antirotavirus y triple viral (SRP) fueron de 78...
June 15, 2023: Salud Pública de México
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