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https://www.readbyqxmd.com/read/28728998/sialylation-of-igg-antibodies-inhibits-igg-mediated-allergic-reactions
#1
Alexandra Epp, Juliane Hobusch, Yannic C Bartsch, Janina Petry, Gina-Maria Lilienthal, Carolien A M Koeleman, Simon Eschweiler, Christian Möbs, Ashley Hall, Suzanne C Morris, Dominique Braumann, Christine Engellenner, Josephine Bitterling, Johann Rahmöller, Alexei Leliavski, Robina Thurmann, Mattias Collin, Kelley W Moremen, Richard T Strait, Véronique Blanchard, Arnd Petersen, Timo Gemoll, Jens K Habermann, Frank Petersen, Andreas Nandy, Helga Kahlert, Michael Hertl, Manfred Wuhrer, Wolfgang Pfützner, Uta Jappe, Fred D Finkelman, Marc Ehlers
In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.
July 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28721460/the-degree-of-shoulder-involvement-in-sports-dosis-scale-is-a-valid-and-responsive-instrumentation-for-shoulder-assessment-in-patients-after-surgery-for-anterior-instability
#2
Alberto Vascellari, Carlo Ramponi, Davide Venturin, Giulia Ben, Davide Blonna, Nicolò Coletti
PURPOSE: The purpose of this study was to evaluate validity and responsiveness of the Degree of Shoulder Involvement in Sport (DOSIS) scale. METHODS: A web-based survey was developed to test the construct validity of the DOSIS scale. Fifty-three patients with a median age of 33 years (range 17-59) were included in the study. Convergent validity was evaluated by external correlation (Spearman's rank correlation coefficient, r) of the DOSIS with the Brophy-Marx and Tegner activity scales, the Western Ontario shoulder instability index (WOSI), the Simple Shoulder Test (SST), and the Short-Form 36 (SF-36)...
July 18, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28702532/a-supramolecular-miktoarm-star-polymer-based-on-porphyrin-metal-complexation-in-water
#3
Zhanyao Hou, Wim Dehaen, Joël Lyskawa, Patrice Woisel, Richard Hoogenboom
A novel supramolecular miktoarm star polymer was successfully constructed in water from a pyridine end-decorated polymer (Py-PmDEGA) and a metalloporphyrin based star polymer (ZnTPP-(PEG)4) via metal-ligand coordination. The Py-PmDEGA moiety was prepared via a combination of reversible addition-fragmentation chain transfer polymerization (RAFT) and subsequent aminolysis and Michael addition reactions to introduce the pyridine end-group. The ZnTPP(PEG)4 star-polymer was synthesized by the reaction between tetrakis(p-hydroxyphenyl)porphyrin and toluenesulfonyl-PEG, followed by insertion of a zinc ion into the porphyrin core...
July 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28682066/charge-effect-on-the-formation-of-polyoxometalate-based-supramolecular-polygons-driven-by-metal-coordination
#4
Madeleine Piot, Sébastien Hupin, Hélène Lavanant, Carlos Afonso, Laurent Bouteiller, Anna Proust, Guillaume Izzet
The metal-driven self-assembly of a Keggin-based hybrid bearing two remote pyridine units was investigated. The resulting supramolecular species were identified by combination of 2D diffusion NMR spectroscopy (DOSY) and electrospray ionization mass spectrometry (ESI-MS) as a mixture of molecular triangles and squares. This behavior is different from that of the structural analogue Dawson-based hybrid displaying a higher charge, which only led to the formation of molecular triangles. This study highlights the decisive effect of the charge of the POMs in their self-assembly processes that disfavors the formation of large assemblies...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28679773/bevacizumab-induces-acute-hypoxia-and-cancer-progression-in-patients-with-refractory-breast-cancer-multimodal-functional-imaging-and-multiplex-cytokine-analysis
#5
Shigeto Ueda, Toshiaki Saeki, Akihiko Osaki, Tomohiko Yamane, Ichiei Kuji
Bevacizumab, an antibody against endothelial growth factor, is a key but controversial drug in the treatment of metastatic breast cancer. We, therefore, aimed to determine the intrinsic resistance to bevacizumab at the physiological and molecular levels in advanced breast cancer using positron emission tomography (PET), dynamic contrast-enhanced MRI, diffuse optical spectroscopic imaging (DOSI), and multiplex cytokine assays.<br />Experimental Design: In total, 28 patients diagnosed with stage III/IV advanced breast cancer receiving single-agent bevacizumab for 1 week followed by paclitaxel combined with bevacizumab underwent (18)F-fluorodeoxyglucose (FDG)-PET, (18)F-fluoromisonidazole (FMISO)-PET, and MRI at both baseline and two courses after treatment initiation...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28679205/metabolism-of-food-borne-heterocyclic-aromatic-amines-by-lactobacillus-reuteri-dsm-20016
#6
Falco Beer, Felix Urbat, Jan Steck, Melanie Huch, Diana Bunzel, Mirko Bunzel, Sabine E Kulling
The heterocyclic aromatic amine (HAA) 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is converted into 7-hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3',2':4,5]imidazo[1,2-a]pyrimidin-5-ium chloride (PhIP-M1) via a chemical reaction with 3-hydroxypropionaldehyde or acrolein derived from glycerol by reuterin producing gut bacteria. Because it is unknown whether this reaction is also relevant for other HAAs, seven food-borne HAAs (2-amino-9H-pyrido[2,3-b]indole (AαC), 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 9H-pyrido[3,4-b]indole (norharman), and 1-methyl-9H-pyrido[3,4-b]indole (harman)) were anaerobically incubated with Lactobacillus reuteri DSM 20016 in the presence of glycerol...
July 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28677189/radiosensibilisierung-durch-braf-inhibitoren
#7
Sophia Boyoung Strobel, Sylvie Pätzold, Lisa Zimmer, Alexandra Jensen, Alexander Enk, Jessica Cecile Hassel
HINTERGRUND: In der letzten Zeit wurden in der Literatur vermehrt erhöhte Hauttoxizitäten während einer Kombinationstherapie mit BRAF Inhibitoren und Radiotherapie beschrieben. MATERIAL UND METHODIK: Wir berichten über sieben Melanompatienten in einem nicht resezierbaren Stadium III oder IV, die eine kombinierte Behandlung aus Bestrahlung und BRAF-Inhibitor erhielten. ERGEBNISSE: Bei allen Patienten konnte durch die Kombinationstherapie ein gutes lokales Ansprechen erreicht werden...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28668409/a-bmi-adjusted-ultra-low-dose-ct-angiography-protocol-for-the-peripheral-arteries-image-quality-diagnostic-accuracy-and-radiation-exposure
#8
Markus M Schreiner, Hannes Platzgummer, Sylvia Unterhumer, Michael Weber, Gabriel Mistelbauer, Christian Loewe, Ruediger E Schernthaner
OBJECTIVES: To investigate radiation exposure, objective image quality, and the diagnostic accuracy of a BMI-adjusted ultra-low-dose CT angiography (CTA) protocol for the assessment of peripheral arterial disease (PAD), with digital subtraction angiography (DSA) as the standard of reference. METHODS: In this prospective, IRB-approved study, 40 PAD patients (30 male, mean age 72 years) underwent CTA on a dual-source CT scanner at 80kV tube voltage. The reference amplitude for tube current modulation was personalized based on the body mass index (BMI) with 120 mAs for [BMI≤25] or 150 mAs for [25<BMI≤30]...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28665506/simultaneous-endo-and-exo-complex-formation-of-pyridine-4-arene-dimer-with-neutral-and-anionic-guests
#9
Anniina Kiesilä, Lauri Kivijärvi, Ngong Kodiah Beyeh, Jani Moilanen, Michael Groessl, Filip Topic, Tatiana Rothe, Sven Götz, Kari Rissanen, Arne Lützen, Elina Kalenius
Complex formation between hexafluorophosphate (PF6-) and tetraisobutyl-octahydroxypyridine[4]arene (1) has been thoroughly studied in gas phase (ESI-QTOF-MS, IM-MS, DFT calculations), solid state (X-ray crystallography) and in chloroform solution (1H, 19F and DOSY NMR). In all states of matter, simultaneous endo-complexation of solvent molecules and exo-complexation of PF6- anion within pyridine[4]arene dimer was observed. While similar ternary complex formation is often observed in solid state, this is a unique example of such behaviour in the gas phase that has never been observed so far...
June 30, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28627214/efectos-del-t%C3%A3-verde-y-su-contenido-de-galato-de-epigalocatequina-egcg-sobre-el-peso-corporal-y-la-masa-grasa-en-humanos-una-revisi%C3%A3-n-sistem%C3%A3-tica
#10
Lucía Cristina Vázquez Cisneros, Patricia López-Uriarte, Antonio López-Espinoza, Mónica Navarro Meza, Ana Cristina Espinoza-Gallardo, Martha Beatriz Guzmán Aburto
La prevalencia e incidencia del sobrepeso y la obesidad continúan en aumento a nivel mundial, así como las enfermedades relacionadas con estas condiciones. Ello se atribuye a un incremento en la ingesta de energía y una disminución en el gasto de la misma. El consumo de té verde se ha relacionado con una reducción en la grasa y el peso corporal. Sin embargo, las investigaciones realizadas con el té verde han sido muy diversas. Esta revisión sistemática explora las investigaciones que se han realizado con té verde y su contenido de galato de epigalocatequina (EGCG) evaluando su efecto sobre la grasa y el peso corporal en humanos...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28627182/factores-predictores-de-hipertrigliceridemia-en-pacientes-hospitalizados-con-nutrici%C3%A3-n-parenteral-total
#11
Maria Julia Ocón Bretón, Ana Isabel Ilundain Gonzalez, Jara Altemir Trallero, Ana Agudo Tabuenca, José Antonio Gimeno Orna
Introducción:la nutrición parenteral total (NPT) es una modalidad de soporte nutricional indicada en aquellas situaciones donde el enfermo no puede cubrir sus requerimientos nutricionales por vía enteral. A pesar de ser una terapia segura y efi caz, no está exenta de complicaciones, entre las que cabe destacar, por su frecuencia, la hipertrigliceridemia. La etiología de esta complicación metabólica es compleja y multifactorial.Objetivos: el objetivo de este trabajo fue determinar los factores de riesgo asociados al desarrollo de hipertrigliceridemia en pacientes adultos hospitalizados no críticos que reciben NPT a corto plazo y evaluar el efecto que una emulsión lipídica enriquecida en ácidos grasos poliinsaturados omega-3 ejerce sobre esta complicación metabólica...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28602503/analysis-using-size-exclusion-chromatography-of-poly-n-isopropyl-acrylamide-using-methanol-as-an-eluent
#12
Thomas Swift, Richard Hoskins, Richard Telford, Richard Plenderleith, David Pownall, Stephen Rimmer
Size Exclusion Chromatography is traditionally carried out in either aqueous or non-polar solvents. A system to present molar mass distributions of polymers using methanol as a mobile phase is presented. This is shown to be a suitable system for determining the molar mass distributions poly(N-isopropylacrylamide)s (PNIPAM); a polymer class that is often difficult to analyze by size exclusion chromatography. DOSY NMR was used to provide intrinsic viscosity data that was used in conjunction with a viscometric detector to provide absolute calibration...
July 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28602187/desi-ms-imaging-and-nmr-spectroscopy-to-investigate-the-influence-of-biodiesel-in-the-structure-of-commercial-rubbers
#13
Lorena M A Silva, Elenilson G Alves Filho, André J Simpson, Marcos R Monteiro, Elaine Cabral, Demian Ifa, Tiago Venâncio
Biodiesel has been introduced as an energetic matrix in several countries around the world. However, the affinity of biodiesel with the components of petrodiesel engines is a growing concern. In order to obtain information regarding the effect of biodiesel on the rubber structure, nuclear magnetic resonance technics under a new technology named as comprehensive multiphase (CMP NMR) and the imaging through desorption electrospray ionization mass spectrometry (DESI-MS imaging) were used. The (1)H CMP-DOSY NMR showed the entrapped fuel into the rubber cavities, which the higher constraint caused by the rubber structure is related to the smaller diffusion coefficient...
October 1, 2017: Talanta
https://www.readbyqxmd.com/read/28590559/dosy-analysis-of-micromolar-analytes-resolving-dilute-mixtures-by-sabre-hyperpolarization
#14
Indrek Reile, Ruud L E G Aspers, Jean-Max Tyburn, James G Kempf, Martin C Feiters, Floris P J T Rutjes, Marco Tessari
DOSY is an NMR spectroscopy technique that resolves resonances according to the analytes' diffusion coefficients. It has found use in correlating NMR signals and estimating the number of components in mixtures. Applications of DOSY in dilute mixtures are, however, held back by excessively long measurement times. We demonstrate herein, how the enhanced NMR sensitivity provided by SABRE hyperpolarization allows DOSY analysis of low-micromolar mixtures, thus reducing the concentration requirements by at least 100-fold...
June 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28562035/ligand-binding-constants-to-lithium-hexamethyldisilazide-determined-by-diffusion-ordered-nmr-spectroscopy
#15
Onkei Tai, Russell Hopson, Paul G Williard
We report the direct measurement of ligand-binding constants of organolithium complexes using a (1)H NMR/diffusion-ordered NMR spectroscopy (DOSY) titration technique. Lithium hexamethyldisilazide complexes with ethereal and ester donor ligands (THF, diethyl ether, MTBE, THP, tert-butyl acetate) are characterized using (1)H NMR and X-ray crystallography. Their aggregation and solvation states are confirmed using diffusion coefficient-formula weight correlation analysis, and the (1)H NMR/DOSY titration technique is applied to obtain their binding constants...
June 8, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28514507/hydrogen-bond-involving-cavity-nh-protons-drives-supramolecular-oligomerization-of-amido-corroles
#16
Daniel T Gryko, Rafał Orłowski, Mariusz Tasior, Barbara Ventura, Olga Staszewska-Krajewska, Wojciech Schilf, Michał Cyrański, Łukasz Dobrzycki
Trans-A2B-Corroles with amide substituents at different positions versus the macrocyclic core have been synthesized. Their self-organizing properties have been comprehensively evaluated both in solid-state and in solution. The rigid arrangement of the amide functionality with the corrole ring led to the formation of strong intramolecular interactions and precluded intermolecular interactions. Replacement of sterically hindered C6F5 substituents at positions 5 and 15 with smaller electron-withdrawing CO2Me groups resulted in significant changes in the self-assembly pattern...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28510440/fundamental-characterization-of-the-micellar-self-assembly-of-sophorolipid-esters
#17
Amanda Koh, Katherine Todd, Ezekiel Sherbourne, Richard A Gross
Surfactants are ubiquitous constituents of commercial and biological systems that function based on complex structure-dependent interactions. Sophorolipid (SL) n-alkyl esters (SL-esters) comprise a group of modified naturally derived glycolipids from Candida bombicola. Herein, micellar self-assembly behavior as a function of SL-ester chain length was studied. Surface tensions as low as 31.2 mN/m and critical micelle concentrations (CMCs) as low as 1.1 μM were attained for diacetylated SL-decyl ester (dASL-DE) and SL-octyl ester, respectively...
June 1, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28509541/synthesis-characterization-and-variable-temperature-nmr-studies-of-silver-i-complexes-for-selective-nitrene-transfer
#18
Minxue Huang, Joshua R Corbin, Nicholas S Dolan, Charles G Fry, Anastasiya I Vinokur, Ilia A Guzei, Jennifer M Schomaker
An array of silver complexes supported by nitrogen-donor ligands catalyze the transformation of C═C and C-H bonds to valuable C-N bonds via nitrene transfer. The ability to achieve high chemoselectivity and site selectivity in an amination event requires an understanding of both the solid- and solution-state behavior of these catalysts. X-ray structural characterizations were helpful in determining ligand features that promote the formation of monomeric versus dimeric complexes. Variable-temperature (1)H and DOSY NMR experiments were especially useful for understanding how the ligand identity influences the nuclearity, coordination number, and fluxional behavior of silver(I) complexes in solution...
May 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28508392/polyoxometalate-engineered-building-blocks-with-gold-cores-for-the-self-assembly-of-responsive-water-soluble-nanostructures
#19
Yizhan Wang, Manoj Raula, Yifeng Wang, Offer Zeiri, Sourav Chakraborty, Gal Gan-Or, Eyal Gadot, Ira A Weinstock
The controlled assembly of gold nanoparticles (AuNPs) with the size of quantum dots into predictable structures is extremely challenging as it requires the quantitatively and topologically precise placement of anisotropic domains on their small, approximately spherical surfaces. We herein address this problem by using polyoxometalate leaving groups to transform 2 nm diameter gold cores into reactive building blocks with hydrophilic and hydrophobic surface domains whose relative sizes can be precisely tuned to give dimers, clusters, and larger micelle-like organizations...
June 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28507679/-ag115s34-sch2c6h4-t-bu-47-dpph-6-synthesis-crystal-structure-and-nmr-investigations-of-a-soluble-silver-chalcogenide-nanocluster
#20
Sebastian Bestgen, Olaf Fuhr, Ben Breitung, Venkata Sei Kiran Chakravadhanula, Gisela Guthausen, Frank Hennrich, Wen Yu, Manfred M Kappes, Peter W Roesky, Dieter Fenske
With the aim to synthesize soluble cluster molecules, the silver salt of (4-(tert-butyl)phenyl)methanethiol [AgSCH2C6H4(t) Bu] was applied as a suitable precursor for the formation of a nanoscale silver sulfide cluster. In the presence of 1,6-(diphenylphosphino)hexane (dpph), the 115 nuclear silver cluster [Ag115S34(SCH2C6H4(t) Bu)47(dpph)6] was obtained. The molecular structure of this compound was elucidated by single crystal X-ray analysis and fully characterized by spectroscopic techniques. In contrast to most of the previously published cluster compounds with more than a hundred heavy atoms, this nanoscale inorganic molecule is soluble in organic solvents, which allowed a comprehensive investigation in solution by UV-Vis spectroscopy and one- and two-dimensional NMR spectroscopy including (31)P/(109)Ag-HSQC and DOSY experiments...
March 1, 2017: Chemical Science
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