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Kamran Balighi, Maryam Daneshpazhooh, Nessa Aghazadeh, Vahide Saeidi, Farzam Shahpouri, Pardis Hejazi, Cheyda Chams-Davatchi
HINTERGRUND UND ZIELE: Pemphigus vulgaris (PV) wird in der Regel mit systemischen Corticosteroiden und Immunsuppressiva behandelt. Avaskuläre Nekrose (AVN) des Hüftkopfes ist eine gut bekannte schwerere Komplikation einer Corticosteroid-Therapie. Die Charakteristika dieser schweren Komplikation bei PV sind nach wie vor unbekannt. PATIENTEN UND METHODEN: Nicht kontrollierte, retrospektive Untersuchung aller PV-bedingten AVN-Fälle, die in einer iranischen Klinik für bullöse Autoimmunerkrankungen zwischen 1985 und 2013 diagnostiziert wurden...
October 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Sebastian Bachmann, Björn Gernert, Dietmar Stalke
In this paper we present the aggregational motifs of the widely used alkali-metal cyclopentadienides (CpLi, CpNa, CpK, CpRb, CpCs) in THF-d8 solution estimated by ECC-DOSY NMR spectroscopy. They form monomeric contact ion pairs (CIPs) in THF-d8 solution, whereas in NH3 solvent-separated ion pairs (SSIPs) are observed. The applicability of ECC-DOSY is further advanced by introducing ECC-MW estimation software.
October 12, 2016: Chemical Communications: Chem Comm
Soumen K Samanta, Damien Moncelet, Volker Briken, Lyle Isaacs
Self-assembly of ligand 1 and Pd(NO3)2 delivers Fujita-type metal organic polyhedron (MOP) 3 which bears 24 covalently attached methyl viologen units on its external surface as evidenced by 1H NMR, DOSY NMR, electrospray mass spectrometry, TEM, and AFM measurements. MOP 3 undergoes non-covalent complexation with cucurbit[n]urils to yield MOPs 4 - 6 with diameter ≈ 5-6 nm. MOP 5 can be fully loaded with doxorubicin prodrug 2 via hetero ternary complex formation to yield 7. The MOPs exhibit excellent stability toward neutral to slightly acidic pH in 10 mM sodium phosphate buffer mitigating the concern of disassembly during circulation...
October 10, 2016: Journal of the American Chemical Society
Yan Qiao, Wenzhi Ge, Lingyu Jia, Xianglin Hou, Yingxiong Wang, Christian M Pedersen
Low temperature (1)H- and (19)F-DOSY have been used for analyzing reactive intermediates in glycosylation reactions, where a glycosyl trichloroacetimidate donor has been activated using different catalysts. The DOSY protocols have been optimized for low temperature experiments and provided new insight into acid catalyzed glycosylation chemistry. From the study a new glycosylation intermediate was characterized.
September 15, 2016: Chemical Communications: Chem Comm
Lotta Turunen, Ulrike Warzok, Rakesh Puttreddy, Ngong Kodiah Beyeh, Christoph A Schalley, Kari Rissanen
Two [N⋅⋅⋅I(+) ⋅⋅⋅N] halogen-bonded dimeric capsules using tetrakis(3-pyridyl)ethylene cavitands with different lower rim alkyl chains are synthesized and analyzed in solution and the gas phase. These first examples of symmetrical dimeric capsules making use of the iodonium ion (I(+) ) as the main connecting module are characterized by (1) H NMR spectroscopy, diffusion ordered NMR spectroscopy (DOSY), electrospray ionization mass spectrometry (ESI-MS), and ion mobility-mass spectrometry (TW-IMS) experiments...
October 6, 2016: Angewandte Chemie
Shogo Morisako, Rong Shang, Yohsuke Yamamoto
The new sterically hindered piperidine analog, dispiro[cyclohexane-2,2'-piperidine-6',2″-cyclohexane] (CPC(H), 2), and its N-methylated derivative CPC(Me) (3) were synthesized from commercially available starting materials in short steps. The N-lithiated amide LiCPC (4) was also isolated from 2 as a cyclictrimer in single crystals and showed slightly larger steric hindrance than that of lithium 2,2,6,6-tetramethylpiperidide (LiTMP) in the competitive methylation reaction with methyl trifluoromethanesulfonate...
October 17, 2016: Inorganic Chemistry
Guilherme Dal Poggetto, Victor U Antunes, Mathias Nilsson, Gareth A Morris, Cláudio F Tormena
NMR is the most versatile tool for the analysis of organic compounds and, in combination with DOSY ("Diffusion-Ordered Spectroscopy"), can give information on compounds in complex mixtures without the need for physical separation. In mixtures where the components' diffusion coefficients are nearly identical, for example due to similar sizes, MAD ("Matrix-Assisted DOSY") can help separate the signals of different constituents, resolving their spectra. Unfortunately, DOSY (including MAD) typically fails where signals overlap, as is common in (1) H NMR...
September 28, 2016: Magnetic Resonance in Chemistry: MRC
Giuseppe Consiglio, Ivan Pietro Oliveri, Salvatore Failla, Santo Di Bella
This contribution explores, through detailed (1)H NMR, DOSY NMR, optical absorption, and circular dichroism spectroscopic studies, the aggregation properties in solution of noncoordinating solvents of some new Zn(II) Schiff-base complexes, (R)-1, (S)-1, and (R)-2, derived from the chiral trans-1,2-diaminocyclohexane. It is found that chloroform solutions of 1 are characterized by the presence of three species, the predominance of which consists of large oligomeric aggregates. For chloroform solutions of 1, upon heating or standing, all species are irreversibly converted into a dimer, 1C, which is very stable and hardly disaggregable...
October 17, 2016: Inorganic Chemistry
Witold M Bloch, Yoko Abe, Julian J Holstein, Claudia M Wandtke, Birger Dittrich, Guido H Clever
Due to the inherent difficulties in achieving a defined and exclusive formation of multicomponent assemblies against entropic predisposition, we present the rational assembly of a heteroleptic [Pd2L(A)2L(B)2](4+) coordination cage achieved through the geometric complementarity of two carefully designed ligands, L(A) and L(B). With Pd(II) cations as rigid nodes, the pure distinctly angular components readily form homoleptic cages, a [Pd2L(A)4](4+) strained helical assembly and a [Pd4L(B)8](8+) box-like structure, both of which were characterized by X-ray analysis...
October 6, 2016: Journal of the American Chemical Society
Tanvi Dosi, Dhaman Gupta, Alka Hazari, Rajan Rajput, Prabhav Chauhan, Anushri S Rajapuri
AIMS AND OBJECTIVES: To study the genotoxic effects of tobacco on the exfoliated buccal epithelial cells in patients with oral precancerous lesions (OPLs) and Patients with tobacco habit but without oral precancerous lesion(habit controls) by using micronucleus assay as well as the quantification and detection of the biomarkers in these premalignant lesions which will be helpful in finding those patients who are at higher risk for malignant transformation. MATERIALS AND METHODS: Forty samples were collected from the right and left side of buccal epithelial cells obtained from 20 individuals, i...
August 2016: Journal of International Society of Preventive & Community Dentistry
Laura Alcázar, Gabriel Aullón, Montserrat Ferrer, Manuel Martínez
The facile redox-assisted assembly of a water-soluble, extremely robust, cyanide-bridged mixed-valence [{Co(III) {(Me)2 (μ-ET)cyclen}}2 {(μ-NC)2 Fe(II) (CN)4 }2 ](2-) square is reported. The preparation process involved the use of the enhanced lability of inert Co(III) synthons triggered by outer-sphere redox processes. Characterization of the final compounds has been carried out by NMR, UV/Vis, electrochemistry, and ICP analyses. DFT calculations have been conducted to optimize a structure that has the same hydrodynamic radius as that obtained from DOSY experiments...
October 17, 2016: Chemistry: a European Journal
Karan Uppal, Douglas I Walker, Ken Liu, Shuzhao Li, Young-Mi Go, Dean P Jones
"Sola dosis facit venenum." These words of Paracelsus, "the dose makes the poison", can lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance environmental chemicals to which humans are exposed. Exposome research teaches that 80-85% of human disease is linked to environmental exposures. The human exposome is estimated to include >400,000 environmental chemicals, most of which are uncharacterized with regard to human health. In fact, mass spectrometry measures >200,000 m/z features (ions) in microliter volumes derived from human samples; most are unidentified...
October 12, 2016: Chemical Research in Toxicology
Kumar Padmapriya, Ritu Barthwal
Stabilization of G-quadruplex DNA structures in human telomeric and proto-oncogenic promoter regions upon ligand binding has evolved as a viable anti-cancer strategy. We have studied interaction of coralyne, a human telomerase inhibiting protoberberine alkaloid, with parallel stranded tetrameric G-quadruplex DNA [d(T2G4T)]4 using Circular Dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy. Appearance of induced CD band and the Diffusion Ordered NMR Spectroscopy (DOSY) experiments confirm the formation of well defined coralyne-DNA complex...
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
Nancy Watfa, Mohamed Haouas, Sébastien Floquet, Akram Hijazi, Daoud Naoufal, Francis Taulelle, Emmanuel Cadot
The host-guest interactions between the spherical porous Keplerate anion, [Mo132O372(CH3CO2)30(H2O)72](42-) (abbreviated {Mo132}) and the tetramethylammonium cation have been investigated extensively by one- and two-dimensional (EXSY, ROESY, and DOSY) and variable-temperature NMR. Evidence of two inner receptor sites specific for a NMe4(+) guest appears consistent with a quite striking compartmentalization phenomenon. ROESY NMR analyses showed that both sites exhibit a close spatial proximity with the hanging inner acetate groups, while a quantitative EXSY study revealed that these two sites are differentiated by their exchange rates...
September 19, 2016: Inorganic Chemistry
Rosa María Martínez García
El embarazo representa un desafío desde el punto de vista nutricional, debido a que las necesidades de nutrientes están aumentadas y una alteración en su ingesta puede afectar la salud materno-fetal. Estados deficitarios en micronutrientes están relacionados con preeclampsia, retraso del crecimiento intrauterino, aborto y anomalías congénitas. Actualmente, la dieta de muchas madres gestantes es insuficiente en micronutrientes, siendo necesaria su suplementación. Se recomienda la suplementación con ácido fólico en dosis de 400 μg/día, y de 5 mg en embarazadas de riesgo, debiendo comenzar al menos 1 mes antes de la concepción y durante las primeras 12 semanas de gestación, y prolongarla durante todo el embarazo en madres con riesgo nutricional...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Lisa J Gould, Garima Dosi, Kara Couch, Gary W Gibbons, Raelina S Howell, Harold Brem, Marjana Tomic-Canic
BACKGROUND: Venous leg ulcers (VLUs) represent the most common ulcers of the lower extremity. VLUs are notorious for delayed and prolonged healing with high rates of recurrence. Most patients with VLUs also have significant comorbidities that interfere with primary wound healing. Thus, caring for patients with VLUs requires an interdisciplinary approach that addresses the abnormal venous anatomy and the downstream effects that lead to inflammation, ulceration, and a hostile wound microenvironment...
September 2016: Plastic and Reconstructive Surgery
Jeffery D Kent, Robert J Holt, Donald Jung, George F Tidmarsh, Amy Y Grahn, Julie Ball, David A Peura
OBJECTIVE: Famotidine given at a dose of 80 mg/day is effective in preventing NSAID-induced gastropathy. The aim of this proof of concept study was to compare twice a day (BID) vs 3-times a day (TID) administration of this total dose of famotidine on intragastric pH in healthy volunteers. RESEARCH DESIGN AND METHODS: Two analyses were undertaken: (1) a 13 subject controlled cross-over 24-h intragastric pH evaluation of the BID and TID administration of 80 mg/day of famotidine, as well as measures for drug accumulation over 5 days (EudraCT, number 2006-002930-39); and (2) a pharmacokinetic (PK)/pharmacodynamic (PD) model which predicted steady-state famotidine plasma concentrations and pH of the two regimens...
2014: J Drug Assess
Yvette Seppenwoolde, Markus Stock, Martin Buschmann, Dietmar Georg, Kwei-Yuang Bauer-Novotny, Richard Pötter, Petra Georg
BACKGROUND AND PURPOSE: Target and organ movement motivate adaptive radiotherapy for cervix cancer patients. We investigated the dosimetric impact of margin concepts with different levels of complexity on both organ at risk (OAR) sparing and PTV coverage. MATERIAL AND METHODS: Weekly CT and daily CBCT scans were delineated for 10 patients. The dosimetric impact of organ shape variations were evaluated for four (isotropic) margin concepts: two static PTVs (PTV6mm and PTV15mm), a PTV based on ITV of the planning CT and CBCTs of the first treatment week (PTVART ITV) and an adaptive PTV based on a library approach (PTVART Library)...
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Bruce J Tromberg, Zheng Zhang, Anaïs Leproux, Thomas D O'Sullivan, Albert E Cerussi, Philip M Carpenter, Rita S Mehta, Darren Roblyer, Wei Yang, Keith D Paulsen, Brian W Pogue, Shudong Jiang, Peter A Kaufman, Arjun G Yodh, So Hyun Chung, Mitchell Schnall, Bradley S Snyder, Nola Hylton, David A Boas, Stefan A Carp, Steven J Isakoff, David Mankoff
The prospective multicenter ACRIN 6691 trial was designed to evaluate whether changes from baseline to mid-therapy in a diffuse optical spectroscopic imaging (DOSI)-derived imaging endpoint, the tissue optical index (TOI), predict pathologic complete response (pCR) in women undergoing breast cancer neoadjuvant chemotherapy (NAC). DOSI instruments were constructed at the University of California, Irvine (Irvine, CA), and delivered to six institutions where 60 subjects with newly diagnosed breast tumors (at least 2 cm in the longest dimension) were enrolled over a 2-year period...
October 15, 2016: Cancer Research
Preeti Rihal Chakrabarti, Shilpi Dosi, Amit Varma, Priyanka Kiyawat, Gaurav Khare, Sandeep Matreja
INTRODUCTION: Testicular and para-testicular neoplasm are rare type of tumours affecting adolescents and young adults, reflected by the paucity of published data in India. AIM: This study was undertaken to estimate the epidemiological characteristics and histological types and subtypes of testicular neoplasm according to the WHO classification in our patient group. Identification of histopathological pattern of testicular tumour is immensely important for improved management protocols...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
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