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https://www.readbyqxmd.com/read/28449457/nomogram-prediction-for-the-survival-of-the-patients-with-small-cell-lung-cancer
#1
Hui Pan, Xiaoshun Shi, Dakai Xiao, Jiaxi He, Yalei Zhang, Wenhua Liang, Zhi Zhao, Zhihua Guo, Xusen Zou, Jinxin Zhang, Jianxing He
BACKGROUND: Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. In this study, we aimed to build a nomogram to predict the survival of individual with SCLC by incorporating significant clinical parameters. METHODS: The patients with SCLC were enrolled from the First Affiliated Hospital of Guangzhou Medical University (GMUFAH) between 2009 and 2013. We identified and incorporated the independent prognostic factors to build a nomogram to predict the survival of SCLC patients...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449370/the-burden-of-autoimmunity-in-myelodysplastic-syndromes
#2
REVIEW
Claudio Fozza
The clinical history of patients with myelodysplastic syndromes (MDS) is characterised by bone marrow insufficiency as well as by the possible evolution into acute leukaemia. However a number of reports highlight the frequent occurrence of autoimmune manifestations involving different sites and organs. The present review will first describe the clinical pictures most often observed in MDS patients. The actual burden of autoimmunity will be then addressed by focusing on the few available registry studies. Finally, the potential collateral impact of specific treatments for MDS on the evolution of autoimmune disorders will be considered...
April 27, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28449293/a-novel-approach-to-study-medical-decision-making-in-the-clinical-setting-the-own-point-of-view-perspective
#3
Thierry Pelaccia, Jacques Tardif, Emmanuel Triby, Bernard Charlin
BACKGROUND: Making diagnostic and therapeutic decisions is a critical activity among physicians. It relies on the ability of physicians to use cognitive processes and specific knowledge in the context of a clinical reasoning. This ability is a core competency in physicians, especially in the field of emergency medicine where the rate of diagnostic errors is high. Studies that explore medical decision-making in an authentic setting are increasing significantly. They are based on the use of qualitative methods which are applied at two separate times: 1) a video recording of the subject's actual activity in an authentic setting and 2) an interview with the subject, supported by the video recording...
April 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28449257/the-development-and-application-of-random-match-probabilities-to-firearm-and-toolmark-identification
#4
John E Murdock, Nicholas D K Petraco, John I Thornton, Michael T Neel, Todd J Weller, Robert M Thompson, James E Hamby, Eric R Collins
The field of firearms and toolmark analysis has encountered deep scrutiny of late, stemming from a handful of voices, primarily in the law and statistical communities. While strong scrutiny is a healthy and necessary part of any scientific endeavor, much of the current criticism leveled at firearm and toolmark analysis is, at best, misinformed and, at worst, punditry. One of the most persistent criticisms stems from the view that as the field lacks quantified random match probability data (or at least a firm statistical model) with which to calculate the probability of a false match, all expert testimony concerning firearm and toolmark identification or source attribution is unreliable and should be ruled inadmissible...
May 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28449127/effects-of-emotional-valence-and-arousal-on-the-voice-perception-network
#5
Patricia E G Bestelmeyer, Sonja A Kotz, Pascal Belin
Several theories conceptualise emotions along two main dimensions: valence (a continuum from negative to positive) and arousal (a continuum that varies from low to high). These dimensions are typically treated as independent in many neuroimaging experiments, yet recent behavioural findings suggest that they are actually interdependent. This result has impact on neuroimaging design, analysis and theoretical development. We were interested in determining the extent of this interdependence both behaviourally and neuroanatomically, as well as teasing apart any activation that is specific to each dimension...
April 25, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28449012/ethnic-inequality-in-diagnosis-with-depression-and-anxiety-disorders
#6
Carol Hj Lee, Isabelle M Duck, Chris G Sibley
AIMS: This study explored ethnic disparities in self-reported diagnosis of depression or an anxiety disorder by a doctor, relative to scores on the screening measure for these same forms of mental illness in a probability sample of New Zealand adults. METHODS: 15,822 participants responded to the 2014/15 New Zealand Attitudes and Values Study (NZAVS) longitudinal panel. Participants completed the Kessler-6 scale (a screening measure of non-specific psychological distress over the last month) and reported whether a doctor had diagnosed them with depression or an anxiety disorder any time in the last five years...
April 28, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28448992/bethesda-made-it-clearer-a-review-of-542-patients-in-a-single-institution
#7
Yunus Acar, Lütfi Doğan, H Erhan Güven, Bülent Aksel, Niyazi Karaman, Cihangir Özaslan, M Ali Gülçelik
BACKGROUND: It is essential to interpret fine needle aspiration biopsy (FNAB) material correctly to create a common language among pathologists and surgeons, leading to a uniform approach to thyroid nodule management. We aimed to compare FNAB reports of patients at our institution who were treated with total thyroidectomy, before and after the Bethesda classification system. PATIENTS AND METHODS: Patients who underwent total thyroidectomy for thyroid nodules are reviewed...
March 21, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28448895/incidence-of-diabetic-ketoacidosis-among-patients-with-type-2-diabetes-mellitus-treated-with-sglt2-inhibitors-and-other-antihyperglycemic-agents
#8
Yiting Wang, Mehul Desai, Patrick B Ryan, Frank J DeFalco, Martijn J Schuemie, Paul E Stang, Jesse A Berlin, Zhong Yuan
AIMS: To estimate and compare incidence of diabetes ketoacidosis (DKA) among patients with type 2 diabetes who are newly treated with SGLT2 inhibitors (SGLT2i) versus non-SGLT2i antihyperglycemic agents (AHAs) in actual clinical practice. METHODS: A new-user cohort study design using a large insurance claims database in the US. DKA incidence was compared between new users of SGLT2i and new users of non-SGLT2i AHAs pair-matched on exposure propensity scores (EPS) using Cox regression models...
April 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28448862/the-first-case-report-of-failed-single-anastomosis-duodeno-ileal-bypass-converted-to-one-anastomosis-gastric-bypass-mini-gastric-bypass
#9
Sonja Chiappetta, Christine Stier, Oliver Scheffel, Sophia Theodoridou, Rudolf Weiner
INTRODUCTION: The established single-anastomosis-duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is based on a sleeve gastrectomy (SG) as the restrictive part of the procedure. Due to preserved pylorus, SG has the disadvantage of a high-pressure system with de novo or worsening of existing gastroesophageal reflux disease (GERD). CASE PRESENTATION: A female patient presented herself due to protracted GERD and weight regain after multiple bariatric surgeries...
April 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28448752/temperature-measurements-in-a-capacitive-system-of-deep-loco-regional-hyperthermia
#10
H Sahinbas, M Rosch, M Demiray
Hyperthermia has been shown to be a medically useful procedure applicable for different indications. For the connection between clinical effects and heat, it is important to understand the actual temperatures achieved in the tissue. There are limited temperature data available when using capacitive hyperthermia devices even though this is worldwide the most widespread method for loco-regional heating. Hence, this study examines temperature measurements using capacitive heating. Bioequivalent phantoms were used for the measurements, which, however, do not consider perfusion in live tissue...
April 27, 2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/28448711/-cemented-polyethylene-insert-in-a-well-fixed-total-knee-replacement-case-report
#11
F E García-Dobarganes Barlow, J Negrete-Corona, A A Díaz-Tovar
We present the case of a 94 years- old patient, which was operated 14 years ago of a right total knee replacement for osteoarthritis, actually she suffers of pain and instability; her X ray shown polyethylene wear without loosening of the metal components. The polyethylene insert is not manufactured anymore so we decided cement a new polyethylene insert on the native tibial baseplate. The two years follow up show us a patient asymptomatic, good function and no radiolucencies on the tibial component. We only found a similar case report in Madrid and we believed that this decision, taken from total hip revisions, will succeed...
September 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28448549/there-was-not-they-did-not-may-negation-cause-the-negated-ideas-to-be-remembered-as-existing
#12
Józef Maciuszek, Romuald Polczyk
In this article we demonstrate that negation of ideas can have paradoxical effects, possibly leading the listener to believe that the negated ideas actually existed. In Experiment 1, participants listened to a description of a house, in which some objects were mentioned, some were negated, and some were not mentioned at all. When questioned about the existence of these objects a week later, the participants gave more false positives for items that were negated in the original material than for items that were not mentioned at all, an effect we call negation related false memories (NRFM)...
2017: PloS One
https://www.readbyqxmd.com/read/28448498/personalized-glucose-forecasting-for-type-2-diabetes-using-data-assimilation
#13
David J Albers, Matthew Levine, Bruce Gluckman, Henry Ginsberg, George Hripcsak, Lena Mamykina
Type 2 diabetes leads to premature death and reduced quality of life for 8% of Americans. Nutrition management is critical to maintaining glycemic control, yet it is difficult to achieve due to the high individual differences in glycemic response to nutrition. Anticipating glycemic impact of different meals can be challenging not only for individuals with diabetes, but also for expert diabetes educators. Personalized computational models that can accurately forecast an impact of a given meal on an individual's blood glucose levels can serve as the engine for a new generation of decision support tools for individuals with diabetes...
April 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28448497/examination-of-an-ehealth-literacy-scale-and-a-health-literacy-scale-in-a-population-with-moderate-to-high-cardiovascular-risk-rasch-analyses
#14
Sarah S Richtering, Rebecca Morris, Sze-Ee Soh, Anna Barker, Fiona Bampi, Lis Neubeck, Genevieve Coorey, John Mulley, John Chalmers, Tim Usherwood, David Peiris, Clara K Chow, Julie Redfern
INTRODUCTION: Electronic health (eHealth) strategies are evolving making it important to have valid scales to assess eHealth and health literacy. Item response theory methods, such as the Rasch measurement model, are increasingly used for the psychometric evaluation of scales. This paper aims to examine the internal construct validity of an eHealth and health literacy scale using Rasch analysis in a population with moderate to high cardiovascular disease risk. METHODS: The first 397 participants of the CONNECT study completed the electronic health Literacy Scale (eHEALS) and the Health Literacy Questionnaire (HLQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28448109/how-medicaid-enrollees-fare-compared-with-privately-insured-and-uninsured-adults-findings-from-the-commonwealth-fund-biennial-health-insurance-survey-2016
#15
Munira Z Gunja, Sara R Collins, David Blumenthal, Michelle M Doty, Sophie Beutel
ISSUE: The number of Americans insured by Medicaid has climbed to more than 70 million, with an estimated 12 million gaining coverage under the Affordable Care Act’s Medicaid expansion. Still, some policymakers have questioned whether Medicaid coverage actually improves access to care, quality of care, or financial protection. GOALS: To compare the experiences of working-age adults who were either: covered all year by private employer or individual insurance; covered by Medicaid for the full year; or uninsured for some time during the year...
April 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28448061/grand-maternal-smoking-in-pregnancy-and-grandchild-s-autistic-traits-and-diagnosed-autism
#16
Jean Golding, Genette Ellis, Steven Gregory, Karen Birmingham, Yasmin Iles-Caven, Dheeraj Rai, Marcus Pembrey
Although there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother's (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28448028/system-for-efficacy-and-cytotoxicity-screening-of-inhibitors-targeting-intracellular-mycobacterium-tuberculosis
#17
Xingji Zheng, Yossef Av-Gay
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a leading cause of morbidity and mortality worldwide. With the increased spread of multi drug-resistant TB (MDR-TB), there is a real urgency to develop new therapeutic strategies against M. tuberculosis infections. Traditionally, compounds are evaluated based on their antibacterial activity under in vitro growth conditions in broth; however, results are often misleading for intracellular pathogens like M. tuberculosis since in-broth phenotypic screening conditions are significantly different from the actual disease conditions within the human body...
April 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447960/an-analytical-reconstruction-model-of-the-spread-out-bragg-peak-using-the-laser-accelerated-proton-beams
#18
Li Tao, Kun Zhu, Jungao Zhu, Xiaohan Xu, Chen Lin, Wenjun Ma, Haiyang Lu, Yanying Zhao, Yuanrong Lu, Jia-Er Chen, Xueqing Yan
With the development of laser technology, laser-driven proton acceleration provides a new way for proton tumor therapy. However, it has not been applied in practice, because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the spread-out Bragg peak (SOBP) using the laser-accelerated proton beams. Firstly, we present a modified weighting formula for protons of different energies. Secondly, a theoretical model for the reconstruction of SOBPs with laser-accelerated proton beams has been built...
April 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28447604/wearable-smart-sensor-systems-integrated-on-soft-contact-lenses-for-wireless-ocular-diagnostics
#19
Joohee Kim, Minji Kim, Mi-Sun Lee, Kukjoo Kim, Sangyoon Ji, Yun-Tae Kim, Jihun Park, Kyungmin Na, Kwi-Hyun Bae, Hong Kyun Kim, Franklin Bien, Chang Young Lee, Jang-Ung Park
Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens...
April 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28447501/imaging-acute-and-chronic-pain-in-the-human-brainstem-and-spinal-cord
#20
Luke A Henderson, Kevin A Keay
While acute pain serves as a protective mechanism designed to warn an individual of potential or actual damaging stimuli, chronic pain provides no benefit and is now considered a disease in its own right. Since the advent of human brain imaging techniques, many investigations that have explored the central representation of acute and chronic pain have focused on changes in higher order brain regions. In contrast, far fewer have explored brainstem and spinal cord function, mainly due to significant technical difficulties...
April 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
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