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https://www.readbyqxmd.com/read/28241717/-application-of-three-dimensional-printing-personalized-acetabular-wing-plate-in-treatment-of-complex-acetabular-fractures-via-lateral-rectus-approach
#1
J G Mai, C Gu, X Z Lin, T Li, W Q Huang, H Wang, X Y Tan, H Lin, Y M Wang, Y Q Yang, D D Jin, S C Fan
Objective: To investigate reduction and fixation of complex acetabular fractures using three-dimensional (3D) printing technique and personalized acetabular wing-plate via lateral-rectus approach. Methods: From March to July 2016, 8 patients with complex acetabular fractures were surgically managed through 3D printing personalized acetabular wing-plate via lateral-rectus approach at Department of Orthopedics, the Third Affiliated Hospital of Southern Medical University. There were 4 male patients and 4 female patients, with an average age of 57 years (ranging from 31 to 76 years)...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28241480/pro-resolving-molecules-new-approaches-to-treat-sepsis
#2
REVIEW
Christa Buechler, Rebekka Pohl, Charalampos Aslanidis
Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches to down-modulate mediators relevant for the onset and duration of inflammation are successful in some chronic diseases, while all of them have failed in sepsis patients. Inflammation and immune suppression characterize sepsis, indicating that anti-inflammatory strategies alone are inappropriate for its therapy...
February 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28241379/necrotising-fasciitis-as-a-complication-of-odontogenic-infection-a-review-of-management-and-case-series
#3
K Bayetto, A Cheng, P Sambrook
OBJECTIVE: To establish the incidence of head and neck necrotising fasciitis (NF) in the Adelaide Oral and Maxillofacial Surgery Unit. To review the current literature regarding the management of head and neck NF. To determine the evidence for the role of hyperbaric oxygen therapy in the management of NF. METHOD: A retrospective audit of all patients admitted to the Royal Adelaide Hospital Oral and Maxillofacial Surgery Unit 2006-2015 with severe odontogenic infections was carried out...
February 27, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28241049/expression-of-cd133-and-cd44-in-glioblastoma-stem-cells-correlates-with-cell-proliferation-phenotype-stability-and-intra-tumor-heterogeneity
#4
Daniel V Brown, Gulay Filiz, Paul M Daniel, Frédéric Hollande, Sebastian Dworkin, Stephanie Amiridis, Nicole Kountouri, Wayne Ng, Andrew P Morokoff, Theo Mantamadiotis
Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to aggressive therapies. Despite this, molecular subtype does not predict recurrence or drug resistance and overall survival is similar across subtypes. One of the key features contributing to tumor recurrence and resistance to therapy is proposed to be an underlying subpopulation of resistant glioma stem cells (GSC)...
2017: PloS One
https://www.readbyqxmd.com/read/28240969/evidence-of-stage-shift-in-women-diagnosed-with-ovarian-cancer-during-phase-ii-of-the-united-kingdom-familial-ovarian-cancer-screening-study
#5
Adam N Rosenthal, Lindsay S M Fraser, Susan Philpott, Ranjit Manchanda, Matthew Burnell, Philip Badman, Richard Hadwin, Ivana Rizzuto, Elizabeth Benjamin, Naveena Singh, D Gareth Evans, Diana M Eccles, Andy Ryan, Robert Liston, Anne Dawnay, Jeremy Ford, Richard Gunu, James Mackay, Steven J Skates, Usha Menon, Ian J Jacobs
Purpose To establish the performance of screening with serum cancer antigen 125 (CA-125), interpreted using the risk of ovarian cancer algorithm (ROCA), and transvaginal sonography (TVS) for women at high risk of ovarian cancer (OC) or fallopian tube cancer (FTC). Patients and Methods Women whose estimated lifetime risk of OC/FTC was ≥ 10% were recruited at 42 centers in the United Kingdom and underwent ROCA screening every 4 months. TVS occurred annually if ROCA results were normal or within 2 months of an abnormal ROCA result...
February 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28240927/contralateral-interictal-and-ictal-eeg-epileptiform-activity-accentuate-memory-impairment-in-unilateral-mesial-temporal-sclerosis-patients
#6
Lecio F Pinto, Carla C Adda, Liliane C A Silva, Natalie H C Banaskiwitz, Valmir Passarelli, Carmen L Jorge, Rosa M Valerio, Luiz H Castro
OBJECTIVE: Memory impairment is a recognized complication of mesial temporal sclerosis (MTS). Epileptiform activity may negatively impact on cognition. We evaluated the impact of contralateral EEG involvement on memory in unilateral MTS (uMTS) patients. METHOD: Retrospective review of 121 right-handed uMTS patients (69 left) evaluated with prolonged video-EEG and verbal and nonverbal memory tests (Rey Auditory Verbal Learning Test and Rey-Osterrieth Complex figure), with additional very delayed trials...
March 2017: Neuropsychology
https://www.readbyqxmd.com/read/28240686/sepsis-patients-display-a-reduced-capacity-to-activate-nuclear-factor-%C3%AE%C2%BAb-in-multiple-cell-types
#7
Arie J Hoogendijk, M Isabel Garcia-Laorden, Lonneke A van Vught, Maryse A Wiewel, Hakima Belkasim-Bohoudi, JanWillem Duitman, Janneke Horn, Marcus J Schultz, Brendon P Scicluna, Cornelis van 't Veer, Alex F de Vos, Tom van der Poll
OBJECTIVES: Sepsis is a complex clinical condition associated with high morbidity and mortality. A distinctive feature of sepsis is the reduced capacity of leukocytes to release proinflammatory cytokines in response to ex vivo stimulation. Cellular signaling events leading to immunosuppression in sepsis are not well defined. We investigated cell-specific signaling events underlying the immunosuppressed phenotype in sepsis. DESIGN: Ex vivo study. SETTING: ICU of an academic hospital...
February 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28240627/a-troubled-asset-relief-program-for-the-patient-centered-medical-home
#8
John Wasson
The patient-centered medical home (PCMH) costs a lot to build and maintain. Deficiencies have become apparent: it has provided few of its advertised benefits and is becoming a troubled asset. A troubled asset relief program for the PCHM is needed (PCMH-TARP). This report presents a PCMH-TARP that places patients' interests first. The PCMH-TARP addresses regulatory barriers and greatly simplifies the complexity of the PCMH blueprint. A disruptively renovated PCMH will stand on a foundation of measures that matter to patients...
April 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28240525/infrapopliteal-calcification-patterns-in-critical-limb-ischemia-diagnostic-pathologic-and-therapeutic-implications-in-the-search-for-the-endovascular-holy-grail
#9
Jihad A Mustapha, Larry J Diaz-Sandoval, Fadi Saab
Critical limb ischemia (CLI) represents the terminal stage of peripheral arterial disease (PAD) and is characterized by multilevel and multivessel disease. Amongst patients with infrainguinal disease, approximately one third have predominantly isolated infrapopliteal disease and the remaining two thirds, a combination of femoropopliteal and infrapopliteal disease. Isolated infrapopliteal disease is mainly seen in the elderly, diabetic, or dialysis-dependent patients. These patients have higher risk of amputation and shorter amputation-free survival...
February 27, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28240497/are-too-many-compression-ultrasounds-being-performed-for-acute-lower-limb-deep-venous-thrombosis-in-tertiary-inpatients
#10
C R de Jager, R J Moont, N E Pearce
BACKGROUND: Venous thromboembolism (VTE) is a complex and serious condition, with high morbidity and mortality, especially in hospitalised patients. Yet its diagnosis remains challenging because of its unspecific clinical presentation. The objective of this study was to apply an algorithmic combination approach to diagnosing VTE by the addition of a D-dimer assay and Wells' criteria for our hospital's internal referral forms requesting compression ultrasound (CUS), to determine the effect on the number of referrals for CUS and the incidence of deep vein thrombosis (DVT) diagnoses...
June 2016: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28240379/different-apathy-clinical-profile-and-neural-correlates-in-behavioral-variant-frontotemporal-dementia-and-alzheimer-s-disease
#11
Marta Fernández-Matarrubia, Jordi A Matías-Guiu, María Nieves Cabrera-Martín, Teresa Moreno-Ramos, María Valles-Salgado, José Luis Carreras, Jorge Matías-Guiu
OBJECTIVES: Apathy is one of the most common and disabling syndromes of dementia. Clinical apathy expression and neuroanatomical basis of apathy seem to differ between behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), although evidence is scarce and poorly understood. Our main purposes were to compare the clinical apathy profile from patients with bvFTD and AD and analyze the relationship between apathy and brain metabolism measured using positron emission tomography imaging with (18) F fluorodeoxyglucose (FDG-PET)...
February 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28240336/a-nanoplasmonic-label-free-surface-enhanced-raman-scattering-strategy-for-non-invasive-cancer-genetic-subtyping-in-patient-samples
#12
Jing Wang, Kevin M Koo, Eugene J H Wee, Yuling Wang, Matt Trau
Simple nucleic acid detection methods could facilitate the progress of disease diagnostics for clinical uses. An attractive strategy is label-free surface-enhanced Raman scattering (SERS) due to its capability of providing structural fingerprinting of analytes that are close to or on nanomaterial surfaces. However, current label-free SERS approaches for DNA/RNA biomarker detection are limited to short and synthetic nucleic acid targets and have not been fully realized in clinical samples due to two possible reasons: (i) low target copies in limited patient samples and (ii) poor capability in identifying specific biomarkers from complex samples...
February 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28240188/parkinson-s-disease-is-accompanied-by-intertwined-alterations-in-iron-metabolism-and-activated-immune-inflammatory-and-oxidative-stress-pathways
#13
Michael Maes, Carine Coneglian De Farias, Kamila Landucci Bonifácio, Andressa Keiko Matsumoto, Chiara Cristina Bortolasci, André de Souza Nogueira, Francis Fregonesi Brinholi, Helena Kaminami Morimoto, Lucio Baena de Melo, Estefânia Gastaldello Moreira, Décio Sabbatini Barbosa
BACKGROUND: Parkinson's diasease (PD) is a neurodegenerative disorder characterized by a complex interplay between peripheral and central inflammatory and oxidative stress pathways. OBJECTIVE: To investigate immune-inflammatory and oxidative stress pathways in relation to iron metabolism in peripheral blood of PD patients and healthy controls. METHODS: We recruited 56 healthy individuals and 56 PD patients in stages 1-3 of Hoehn and Yahr Scale...
February 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28240097/soluble-intercellular-adhesion-molecule-1-a-potential-biomarker-for-pain-intensity-in-chronic-pain-patients
#14
Benjamin Luchting, Ludwig Christian Giuseppe Hinske, Banafscheh Rachinger-Adam, Leo Anthony Celi, Simone Kreth, Shahnaz Christina Azad
AIM: Pain therapy is strongly guided by patients' self-reporting. However, when self-reporting is not an option, pain assessment becomes a challenge and may lead to undertreatment of painful conditions. Pain is a complex and multifactorial phenomenon. Recent work has connected pain pathophysiology also with the inflammatory system. We therefore hypothesized that pain intensity could be predicted by cytokine-levels. PATIENTS & METHODS: In this observational, single-center study, we investigated 30 serum cytokines to predict pain intensity in a screening/follow-up set of 95 chronic pain patients and controls...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28240053/plasma-matrix-metalloprotease-9-correlates-with-blood-lymphocytosis-leukemic-cell-invasiveness-and-prognosis-in-b-cell-chronic-lymphocytic-leukemia
#15
Milena Gusella, Caterina Bolzonella, Rossella Paolini, Elisabetta Rodella, Laura Bertolaso, Cinzia Scipioni, Silvia Bellini, Antonio Cuneo, Felice Pasini, Emilio Ramazzina
The complex biology underlying chronic lymphocytic leukemia cell migration and tissue invasiveness is not yet completely understood and might provide novel predictive markers and therapeutic targets. A total of 36 patients out of treatment from at least 3 months were enrolled and followed up for a median period of 44.2 months (range: 4.4-99.2). Matrix metalloprotease 9 and tissue inhibitor of metalloproteases 1 plasma levels and production/release from lymphoid cells were measured by zymography and enzyme-linked immunosorbent assay (ELISA) analysis...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28239812/the-role-of-neutrophil-lymphocyte-ratio-and-red-blood-cell-distribution-width-in-the-classification-of-febrile-seizures
#16
Y Yigit, S Yilmaz, A Akdogan, H C Halhalli, A E Ozbek, E G Gencer
OBJECTIVE: Most febrile seizures occur outside of hospitals, and in most cases, information about the characteristics of the seizures is obtained from the parents. This makes it difficult to differentiate between simple and complex seizures. The aim of this study is to evaluate the significance of the Neutrophil-Lymphocyte Ratio (NLR) and the red blood cell (erythrocyte) distribution width (RDW) in distinguishing between simple and complex febrile seizures. PATIENTS AND METHODS: The files of 142 patients between the ages of 6 months and 5 years who were admitted to the Emergency Department with the diagnosis of first febrile seizure were reviewed retrospectively...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239597/perceived-cognitive-deficits-are-associated-with-diabetes-self-management-in-a-multiethnic-sample
#17
Heather Cuevas, Alexa Stuifbergen
BACKGROUND: People with diabetes have almost twice the risk of developing cognitive impairment or dementia as do those without diabetes, and about half of older adults with diabetes will become functionally disabled or cognitively impaired. But diabetes requires complex self-management: patients must learn about the implications of their disease; manage their diets, physical activity, and medication; and monitor their blood glucose. Difficulties with cognition can hinder these activities...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28239561/regulation-of-cardiac-cacnb2-by-microrna-499-potential-role-in-atrial-fibrillation
#18
Tian-You Ling, Xiao-Li Wang, Qiang Chai, Tong Lu, John M Stulak, Lyle D Joyce, Richard C Daly, Kevin L Greason, Li-Qun Wu, Win-Kuang Shen, Yong-Mei Cha, Hon-Chi Lee
The L-type calcium channel (LTCC) is one of the major ion channels that are known to be associated with the electrical remodeling of atrial fibrillation (AF). In AF, there is significant downregulation of the LTCC, but the underlying mechanism for such downregulation is not clear. We have previously reported that microRNA-499 (miR-499) is significantly upregulated in patients with permanent AF and that KCNN3, the gene that encodes the small-conductance calcium-activated potassium channel 3 (SK3), is a target of miR-499...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28239544/measures-of-metabolism-and-complexity-in-the-brain-of-patients-with-disorders-of-consciousness
#19
Olivier Bodart, Olivia Gosseries, Sarah Wannez, Aurore Thibaut, Jitka Annen, Melanie Boly, Mario Rosanova, Adenauer G Casali, Silvia Casarotto, Giulio Tononi, Marcello Massimini, Steven Laureys
BACKGROUND: Making an accurate diagnosis in patients with disorders of consciousness remains challenging. (18)F-fluorodeoxyglucose (FDG)-PET has been validated as a diagnostic tool in this population, and allows identifying unresponsive patients with a capacity for consciousness. In parallel, the perturbational complexity index (PCI), a new measure based on the analysis of the electroencephalographic response to transcranial magnetic stimulation, has also been suggested as a tool to distinguish between unconscious and conscious states...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28239502/immunooncology-can-the-right-chimeric-antigen-receptors-t-cell-design-be-made-to-cure-all-types-of-cancers-and-will-it-be-covered
#20
REVIEW
Regina Au
Immunooncology (IO) is the buzz word today and it has everyone doing IO research. If we look back at the history of cancer treatment, the survival rate was measured in months which, according to oncologists, was a lot back then because the mortality rate in most cancers was 100%. However, most traditional chemotherapies were not well tolerated because they would kill both cancerous and healthy cells, which lead to major side effects such as loss of hair, nausea and vomiting, and risk of infection. Survival was better but not much better depending on the type of cancer and the patient's own genetic and physiological make-up...
2017: Journal of Pharmaceutics
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